HLX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.19579623
2positive regulation by symbiont of host defense response (GO:0052509)5.05884368
3modulation by symbiont of host defense response (GO:0052031)5.05884368
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.05884368
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.05884368
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.05884368
7modulation by symbiont of host immune response (GO:0052553)5.05884368
8response to peptidoglycan (GO:0032494)4.96326302
9respiratory burst (GO:0045730)4.36940475
10cellular extravasation (GO:0045123)4.03879493
11immunoglobulin mediated immune response (GO:0016064)3.99662692
12positive regulation of antigen processing and presentation (GO:0002579)3.98295383
13regulation of B cell receptor signaling pathway (GO:0050855)3.95304119
14regulation of dendritic cell antigen processing and presentation (GO:0002604)3.94503396
15response to muramyl dipeptide (GO:0032495)3.91868372
16neutrophil activation (GO:0042119)3.91463074
17regulation of interferon-beta biosynthetic process (GO:0045357)3.82997153
18regulation of vitamin D biosynthetic process (GO:0060556)3.82402298
19leukocyte aggregation (GO:0070486)3.80497582
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.80071909
21Arp2/3 complex-mediated actin nucleation (GO:0034314)3.79022739
22granulocyte activation (GO:0036230)3.73061713
23NIK/NF-kappaB signaling (GO:0038061)3.67573655
24superoxide anion generation (GO:0042554)3.61768038
25response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.58865878
26response to host immune response (GO:0052572)3.58865878
27positive regulation of mast cell activation (GO:0033005)3.58291475
28regulation of mast cell degranulation (GO:0043304)3.57682922
29negative regulation of cell killing (GO:0031342)3.56466885
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56466885
31macrophage activation involved in immune response (GO:0002281)3.54454192
32regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.51763737
33production of molecular mediator involved in inflammatory response (GO:0002532)3.51276732
34negative regulation of cytokine production involved in immune response (GO:0002719)3.49267231
35regulation of antigen processing and presentation (GO:0002577)3.47395922
36positive regulation of interferon-alpha production (GO:0032727)3.42375749
37detection of external biotic stimulus (GO:0098581)3.38968371
38regulation of mast cell activation (GO:0033003)3.38481757
39regulation of mast cell activation involved in immune response (GO:0033006)3.35164877
40* regulation of T-helper 1 cell differentiation (GO:0045625)3.34658708
41positive regulation of chemokine biosynthetic process (GO:0045080)3.32748026
42positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.29125549
43positive regulation of mast cell degranulation (GO:0043306)3.28949780
44positive regulation of mast cell activation involved in immune response (GO:0033008)3.28949780
45regulation of interferon-alpha production (GO:0032647)3.25474269
46positive regulation of type 2 immune response (GO:0002830)3.24069561
47lipopolysaccharide-mediated signaling pathway (GO:0031663)3.24001993
48mature B cell differentiation (GO:0002335)3.23606896
49defense response to protozoan (GO:0042832)3.21188042
50negative regulation of phagocytosis (GO:0050765)3.20974488
51neutrophil mediated immunity (GO:0002446)3.19762856
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.19681843
53response to host (GO:0075136)3.19681843
54response to host defenses (GO:0052200)3.19681843
55myeloid dendritic cell differentiation (GO:0043011)3.18137103
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.17578333
57response to fungus (GO:0009620)3.16756494
58myeloid dendritic cell activation (GO:0001773)3.16356570
59positive regulation of gamma-delta T cell activation (GO:0046645)3.15097625
60T-helper 1 type immune response (GO:0042088)3.14294936
61negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.11672986
62positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.10225009
63regulation of chemokine biosynthetic process (GO:0045073)3.10074942
64regulation of cytokine secretion involved in immune response (GO:0002739)3.09569044
65leukocyte migration involved in inflammatory response (GO:0002523)3.09420277
66positive regulation of B cell differentiation (GO:0045579)3.08702921
67negative regulation of growth of symbiont in host (GO:0044130)3.07926270
68negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.07926270
69modulation of growth of symbiont involved in interaction with host (GO:0044144)3.07926270
70regulation of growth of symbiont in host (GO:0044126)3.07926270
71detection of other organism (GO:0098543)3.07380686
72cellular response to zinc ion (GO:0071294)3.07364411
73detection of biotic stimulus (GO:0009595)3.05290286
74negative regulation of interleukin-12 production (GO:0032695)3.04799365
75positive regulation of cellular amide metabolic process (GO:0034250)3.03352627
76microglial cell activation (GO:0001774)3.03096926
77myeloid cell activation involved in immune response (GO:0002275)3.00986426
78response to protozoan (GO:0001562)2.97733616
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.97525610
80regulation of vitamin metabolic process (GO:0030656)2.96734742
81type I interferon signaling pathway (GO:0060337)2.95378029
82cellular response to type I interferon (GO:0071357)2.95378029
83negative regulation of erythrocyte differentiation (GO:0045647)2.95167755
84response to type I interferon (GO:0034340)2.94912009
85negative regulation of nitric oxide biosynthetic process (GO:0045019)2.94126008
86response to interferon-beta (GO:0035456)2.93793725
87pinocytosis (GO:0006907)2.91084152
88interferon-gamma-mediated signaling pathway (GO:0060333)2.88311330
89regulation of podosome assembly (GO:0071801)2.88197920
90* regulation of T-helper 2 cell differentiation (GO:0045628)2.87924635
91B cell mediated immunity (GO:0019724)2.87471501
92regulation of gamma-delta T cell activation (GO:0046643)2.87245008
93macrophage activation (GO:0042116)2.85491718
94regulation of RIG-I signaling pathway (GO:0039535)2.85389120
95regulation of leukocyte degranulation (GO:0043300)2.83124669
96antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.83094913
97antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.83094913
98negative regulation of T cell mediated immunity (GO:0002710)2.82425368
99negative regulation of mast cell activation (GO:0033004)2.82385897
100negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.82156456
101hydrogen peroxide biosynthetic process (GO:0050665)2.82108151
102negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.81964937
103regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.81445459
104antigen processing and presentation of endogenous antigen (GO:0019883)2.79438717
105regulation of interleukin-12 production (GO:0032655)2.79069107
106negative regulation of tumor necrosis factor production (GO:0032720)2.79025473
107negative regulation of interleukin-6 production (GO:0032715)2.78646852
108positive regulation of heat generation (GO:0031652)2.78065064
109negative regulation of production of molecular mediator of immune response (GO:0002701)2.76541859
110cellular response to interferon-beta (GO:0035458)2.76439563
111positive regulation of NF-kappaB import into nucleus (GO:0042346)2.76036310
112germinal center formation (GO:0002467)2.75660531
113detection of bacterium (GO:0016045)2.75622465
114cellular response to lipopolysaccharide (GO:0071222)2.75271829
115regulation of chronic inflammatory response (GO:0002676)2.74627959
116positive regulation of interleukin-6 production (GO:0032755)2.74252631
117tooth mineralization (GO:0034505)2.74250640
118leukotriene metabolic process (GO:0006691)2.74246298
119regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.74169193
120regulation of interleukin-8 biosynthetic process (GO:0045414)2.73197036
121cellular response to molecule of bacterial origin (GO:0071219)2.72885647
122regulation of interleukin-12 biosynthetic process (GO:0045075)2.72288827
123actin nucleation (GO:0045010)2.71978574
124myeloid leukocyte activation (GO:0002274)2.71627315
125mature B cell differentiation involved in immune response (GO:0002313)2.71606742
126* regulation of type 2 immune response (GO:0002828)2.71366184
127regulation of interleukin-6 production (GO:0032675)2.70991812
128negative regulation of granulocyte differentiation (GO:0030853)2.70200421
129dendritic cell chemotaxis (GO:0002407)2.70000867
130regulation of myeloid leukocyte mediated immunity (GO:0002886)2.69118344
131reactive oxygen species biosynthetic process (GO:1903409)2.68528479
132detection of molecule of bacterial origin (GO:0032490)2.68277878
133macrophage differentiation (GO:0030225)2.67977134
134dendritic cell differentiation (GO:0097028)2.65401775
135positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.64584652
136neutrophil chemotaxis (GO:0030593)2.63554958
137regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.63207028
138regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.61398756
139positive regulation of toll-like receptor signaling pathway (GO:0034123)2.60601376
140cellular response to exogenous dsRNA (GO:0071360)2.60396521
141positive regulation of interferon-beta production (GO:0032728)2.60381790
142leukocyte mediated cytotoxicity (GO:0001909)2.60194794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.97910934
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.45094599
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.72526552
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.91660567
5* IRF8_27001747_Chip-Seq_BMDM_Mouse3.86911935
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.85101698
7MYB_21317192_ChIP-Seq_ERMYB_Mouse3.51232910
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.40324603
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.34388368
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.33835754
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.26003934
12SCL_19346495_ChIP-Seq_HPC-7_Human3.22274035
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.10373043
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.02069995
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.88931279
16SPI1_23547873_ChIP-Seq_NB4_Human2.73264375
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.67264241
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.53972501
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.53961360
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.47178014
21* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.47009304
22* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.46521861
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.45450126
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28993785
25* VDR_24763502_ChIP-Seq_THP-1_Human2.23252386
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.22667954
27* VDR_21846776_ChIP-Seq_THP-1_Human2.21466770
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.07588594
29MAF_26560356_Chip-Seq_TH1_Human2.06942571
30RUNX_20019798_ChIP-Seq_JUKART_Human2.01830423
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.00178963
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.92966746
33MYB_26560356_Chip-Seq_TH2_Human1.88777304
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.88100245
35* PU_27001747_Chip-Seq_BMDM_Mouse1.82387017
36* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75925617
37SPI1_23127762_ChIP-Seq_K562_Human1.75162596
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73847006
39* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.73080266
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.69958768
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.67300740
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65296252
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.64104945
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62748313
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61521280
46LXR_22292898_ChIP-Seq_THP-1_Human1.58812184
47* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58444518
48MYB_26560356_Chip-Seq_TH1_Human1.56004396
49* ELK3_25401928_ChIP-Seq_HUVEC_Human1.52612670
50* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.51072098
51* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50403853
52* VDR_24787735_ChIP-Seq_THP-1_Human1.49821036
53* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49687486
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49275592
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.45234375
56TCF7_22412390_ChIP-Seq_EML_Mouse1.45018248
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44857201
58UTX_26944678_Chip-Seq_JUKART_Human1.42062228
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38939609
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.37944284
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37912828
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36557316
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35342563
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34033298
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32891054
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.32332121
67MAF_26560356_Chip-Seq_TH2_Human1.25118748
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24478899
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22366872
70* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21078765
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15335547
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15232205
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14871248
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.14695461
75* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14575519
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14389140
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13115223
78MYC_22102868_ChIP-Seq_BL_Human1.12047446
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11288185
80* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11179354
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08570206
82* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08564440
83* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07242679
84BCL6_27268052_Chip-Seq_Bcells_Human1.06695556
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06428717
86GATA3_27048872_Chip-Seq_THYMUS_Human1.05151128
87GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04065089
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.01372859
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99419324
90GATA3_26560356_Chip-Seq_TH2_Human0.95796164
91RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95610026
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94998126
93GATA1_22025678_ChIP-Seq_K562_Human0.92825083
94* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92283687
95KDM2B_26808549_Chip-Seq_JURKAT_Human0.91615919
96* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91369773
97KDM2B_26808549_Chip-Seq_K562_Human0.88711774
98SPI1_20517297_ChIP-Seq_HL60_Human0.88488929
99* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86212585
100* GATA1_19941826_ChIP-Seq_K562_Human0.86082136
101PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85731204
102* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85419976
103* BCOR_27268052_Chip-Seq_Bcells_Human0.82952799
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82739733
105* EGR1_19032775_ChIP-ChIP_M12_Human0.82366334
106KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82150705
107KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82150705
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82150705
109* GATA2_19941826_ChIP-Seq_K562_Human0.75953372
110TFEB_21752829_ChIP-Seq_HELA_Human0.74255530
111PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.74051153
112KDM2B_26808549_Chip-Seq_DND41_Human0.73462018
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71377107
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.70366519
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68865171
116P63_26484246_Chip-Seq_KERATINOCYTES_Human0.67800764
117* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.67625518
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.67315687
119STAT1_20625510_ChIP-Seq_HELA_Human0.67081811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.64294420
2MP0003436_decreased_susceptibility_to3.54690548
3MP0003303_peritoneal_inflammation3.53604406
4MP0009785_altered_susceptibility_to3.28192585
5MP0003724_increased_susceptibility_to3.16048663
6MP0002148_abnormal_hypersensitivity_rea3.05874742
7MP0002419_abnormal_innate_immunity2.90225061
8MP0005025_abnormal_response_to2.73564449
9MP0005000_abnormal_immune_tolerance2.69994582
10MP0000685_abnormal_immune_system2.63375016
11MP0009278_abnormal_bone_marrow2.55048131
12MP0001790_abnormal_immune_system2.49264130
13MP0005387_immune_system_phenotype2.49264130
14MP0002452_abnormal_antigen_presenting2.45218318
15MP0004510_myositis2.41765925
16MP0005167_abnormal_blood-brain_barrier2.40569238
17MP0001800_abnormal_humoral_immune2.39734953
18MP0002723_abnormal_immune_serum2.25554712
19MP0005671_abnormal_response_to2.24413837
20MP0005058_abnormal_lysosome_morphology2.21074500
21MP0001819_abnormal_immune_cell2.15978626
22MP0002420_abnormal_adaptive_immunity2.14844005
23MP0006082_CNS_inflammation2.03887768
24MP0005464_abnormal_platelet_physiology1.99189348
25MP0002405_respiratory_system_inflammati1.98316252
26MP0003172_abnormal_lysosome_physiology1.96636320
27MP0000343_altered_response_to1.95488751
28MP0009333_abnormal_splenocyte_physiolog1.94443661
29MP0001545_abnormal_hematopoietic_system1.92433066
30MP0005397_hematopoietic_system_phenotyp1.92433066
31MP0001533_abnormal_skeleton_physiology1.91585775
32MP0001853_heart_inflammation1.90855212
33MP0000465_gastrointestinal_hemorrhage1.87263799
34MP0003828_pulmonary_edema1.82848952
35MP0002138_abnormal_hepatobiliary_system1.82785297
36MP0002166_altered_tumor_susceptibility1.69771805
37MP0008004_abnormal_stomach_pH1.66271330
38MP0009840_abnormal_foam_cell1.64174849
39MP0001845_abnormal_inflammatory_respons1.62486363
40MP0000716_abnormal_immune_system1.62090742
41MP0002398_abnormal_bone_marrow1.60436473
42MP0004808_abnormal_hematopoietic_stem1.58813064
43MP0005174_abnormal_tail_pigmentation1.56794721
44MP0000604_amyloidosis1.55779293
45MP0002139_abnormal_hepatobiliary_system1.54664258
46MP0009764_decreased_sensitivity_to1.53246428
47MP0010155_abnormal_intestine_physiology1.52053790
48MP0003806_abnormal_nucleotide_metabolis1.50463472
49MP0003448_altered_tumor_morphology1.50145289
50MP0003191_abnormal_cellular_cholesterol1.47428322
51MP0002006_tumorigenesis1.47121270
52MP0001879_abnormal_lymphatic_vessel1.45076321
53MP0002277_abnormal_respiratory_mucosa1.43408721
54MP0002396_abnormal_hematopoietic_system1.42056815
55MP0001851_eye_inflammation1.40482381
56* MP0008469_abnormal_protein_level1.40091492
57* MP0002429_abnormal_blood_cell1.36644034
58MP0003075_altered_response_to1.36124157
59MP0000689_abnormal_spleen_morphology1.35761649
60MP0003279_aneurysm1.34924666
61MP0000767_abnormal_smooth_muscle1.32927567
62MP0000858_altered_metastatic_potential1.32586533
63MP0002332_abnormal_exercise_endurance1.31800867
64MP0010368_abnormal_lymphatic_system1.24651141
65MP0002722_abnormal_immune_system1.23527026
66MP0002933_joint_inflammation1.22772861
67MP0000490_abnormal_crypts_of1.19524712
68MP0000015_abnormal_ear_pigmentation1.12937534
69MP0003763_abnormal_thymus_physiology1.11582589
70MP0005310_abnormal_salivary_gland1.11166803
71MP0002998_abnormal_bone_remodeling1.08303384
72MP0000249_abnormal_blood_vessel1.07432296
73MP0003690_abnormal_glial_cell1.06770583
74MP0002254_reproductive_system_inflammat1.06625692
75MP0004947_skin_inflammation1.06551150
76MP0008260_abnormal_autophagy1.05636886
77MP0008961_abnormal_basal_metabolism1.05308973
78MP0002009_preneoplasia1.04133509
79MP0005390_skeleton_phenotype1.02935766
80MP0004782_abnormal_surfactant_physiolog1.02318101
81MP0001958_emphysema0.99670526
82MP0002132_abnormal_respiratory_system0.97680056
83MP0005164_abnormal_response_to0.94822123
84MP0003656_abnormal_erythrocyte_physiolo0.92612160
85MP0003136_yellow_coat_color0.90386385
86MP0001873_stomach_inflammation0.89777446
87MP0003300_gastrointestinal_ulcer0.87005869
88MP0005409_darkened_coat_color0.86680883
89MP0001542_abnormal_bone_strength0.84739800
90MP0005165_increased_susceptibility_to0.84120977
91MP0005166_decreased_susceptibility_to0.83151753
92MP0004883_abnormal_blood_vessel0.81149033
93MP0003453_abnormal_keratinocyte_physiol0.80786323
94MP0004130_abnormal_muscle_cell0.79675920
95MP0003091_abnormal_cell_migration0.78427490
96MP0009763_increased_sensitivity_to0.78032731
97MP0005451_abnormal_body_composition0.77844030
98MP0003195_calcinosis0.75100392
99MP0003329_amyloid_beta_deposits0.74347237
100MP0009379_abnormal_foot_pigmentation0.73428738
101MP0003186_abnormal_redox_activity0.71627724
102MP0000703_abnormal_thymus_morphology0.70006314
103MP0003795_abnormal_bone_structure0.69842962
104MP0008874_decreased_physiological_sensi0.69208786
105MP0003183_abnormal_peptide_metabolism0.69146433
106MP0001663_abnormal_digestive_system0.68845001
107MP0009765_abnormal_xenobiotic_induced0.68825093
108MP0008007_abnormal_cellular_replicative0.68248113
109MP0002095_abnormal_skin_pigmentation0.66015505
110MP0005319_abnormal_enzyme/_coenzyme0.65339629
111MP0004381_abnormal_hair_follicle0.64852237
112MP0005647_abnormal_sex_gland0.63174653
113MP0005595_abnormal_vascular_smooth0.62769983
114MP0003646_muscle_fatigue0.61974704
115MP0009697_abnormal_copulation0.61626149
116MP0003866_abnormal_defecation0.61462821
117MP0000609_abnormal_liver_physiology0.59915360
118MP0000920_abnormal_myelination0.59492592
119MP0008438_abnormal_cutaneous_collagen0.57738608
120MP0003566_abnormal_cell_adhesion0.57499959
121MP0005076_abnormal_cell_differentiation0.57114902
122MP0005535_abnormal_body_temperature0.56372423
123MP0006054_spinal_hemorrhage0.55539221
124MP0005023_abnormal_wound_healing0.55467680

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.65376009
2Eczematoid dermatitis (HP:0000976)6.05368071
3Recurrent bacterial skin infections (HP:0005406)5.78562692
4Recurrent gram-negative bacterial infections (HP:0005420)4.82003052
5Abnormality of macrophages (HP:0004311)4.67685077
6Spontaneous hematomas (HP:0007420)4.29719709
7Elevated erythrocyte sedimentation rate (HP:0003565)4.27051109
8Obstructive lung disease (HP:0006536)4.26381136
9Chronic obstructive pulmonary disease (HP:0006510)4.26381136
10Myositis (HP:0100614)4.25824280
11Mediastinal lymphadenopathy (HP:0100721)4.25446276
12Vacuolated lymphocytes (HP:0001922)4.12743151
13Recurrent skin infections (HP:0001581)4.00594909
14Systemic lupus erythematosus (HP:0002725)3.87162639
15Recurrent fungal infections (HP:0002841)3.73037229
16Loss of speech (HP:0002371)3.72439987
17Orchitis (HP:0100796)3.65313267
18Stomatitis (HP:0010280)3.42885260
19Cellulitis (HP:0100658)3.36576470
20Meningitis (HP:0001287)3.32644349
21Disinhibition (HP:0000734)3.27157479
22Glomerulonephritis (HP:0000099)3.21240835
23Petechiae (HP:0000967)3.20496629
24Hematochezia (HP:0002573)3.20359214
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.19997841
26Gingivitis (HP:0000230)3.14985244
27Recurrent cutaneous fungal infections (HP:0011370)3.14652447
28Chronic mucocutaneous candidiasis (HP:0002728)3.14652447
29Keratoconjunctivitis (HP:0001096)3.03525172
30Recurrent viral infections (HP:0004429)3.00206845
31Optic neuritis (HP:0100653)2.98840342
32Retrobulbar optic neuritis (HP:0100654)2.98840342
33Urticaria (HP:0001025)2.89238845
34Autoimmune thrombocytopenia (HP:0001973)2.83263939
35Chronic otitis media (HP:0000389)2.81307936
36Vasculitis (HP:0002633)2.80314406
37Abnormality of polysaccharide metabolism (HP:0011012)2.76063465
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.76063465
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.76063465
40Prolonged bleeding time (HP:0003010)2.74523947
41Increased neuronal autofluorescent lipopigment (HP:0002074)2.74087549
42Increased cerebral lipofuscin (HP:0011813)2.71847656
43Mutism (HP:0002300)2.70885533
44Dysostosis multiplex (HP:0000943)2.69264081
45Basal ganglia calcification (HP:0002135)2.68203369
46Increased serum ferritin (HP:0003281)2.66580020
47Thrombocytosis (HP:0001894)2.64268336
48Polycythemia (HP:0001901)2.58532022
49Abnormality of the nasal mucosa (HP:0000433)2.56835521
50Reduced antithrombin III activity (HP:0001976)2.55353648
51Nuclear cataract (HP:0100018)2.52810272
52Inflammation of the large intestine (HP:0002037)2.51652445
53Hemoptysis (HP:0002105)2.49460302
54Epistaxis (HP:0000421)2.46115653
55Microcytic anemia (HP:0001935)2.44901715
56Leukocytosis (HP:0001974)2.44434609
57Gangrene (HP:0100758)2.43176044
58Episodic fever (HP:0001954)2.43110635
59Gingival bleeding (HP:0000225)2.39570805
60Gastrointestinal infarctions (HP:0005244)2.38484330
61Arterial thrombosis (HP:0004420)2.36957391
62Periodontitis (HP:0000704)2.34002419
63Recurrent lower respiratory tract infections (HP:0002783)2.33810986
64Colitis (HP:0002583)2.33582593
65Gastrointestinal inflammation (HP:0004386)2.32707548
66Recurrent pneumonia (HP:0006532)2.32533593
67Interstitial pulmonary disease (HP:0006530)2.32092547
68Abnormality of iron homeostasis (HP:0011031)2.28935861
69Autoimmune hemolytic anemia (HP:0001890)2.28285402
70Progressive neurologic deterioration (HP:0002344)2.26682850
71Polyneuropathy (HP:0001271)2.25148926
72Pulmonary infiltrates (HP:0002113)2.24043417
73Purpura (HP:0000979)2.23874134
74Peritonitis (HP:0002586)2.22889102
75Myocardial infarction (HP:0001658)2.22421461
76Anorexia (HP:0002039)2.21980816
77Agammaglobulinemia (HP:0004432)2.17106207
78Osteomyelitis (HP:0002754)2.16945738
79Abnormality of transition element cation homeostasis (HP:0011030)2.16382897
80Abnormality of the pleura (HP:0002103)2.16254581
81Nephritis (HP:0000123)2.15460208
82Pustule (HP:0200039)2.14489814
83Chest pain (HP:0100749)2.12705076
84Exertional dyspnea (HP:0002875)2.11477415
85Abnormality of cells of the erythroid lineage (HP:0012130)2.10299876
86Encephalitis (HP:0002383)2.09109684
87Pulmonary embolism (HP:0002204)2.06977226
88Diminished motivation (HP:0000745)2.06093932
89Abnormal number of erythroid precursors (HP:0012131)2.05361915
90Pulmonary artery stenosis (HP:0004415)2.04768360
91Axonal loss (HP:0003447)2.04363758
92Abnormality of glycolipid metabolism (HP:0010969)2.03005573
93Abnormality of liposaccharide metabolism (HP:0010968)2.03005573
94Abnormality of glycosphingolipid metabolism (HP:0004343)2.03005573
95Apathy (HP:0000741)2.02408779
96IgM deficiency (HP:0002850)2.02102783
97Increased IgE level (HP:0003212)2.01001577
98Thoracic kyphosis (HP:0002942)2.00591837
99Hepatosplenomegaly (HP:0001433)2.00589265
100Polygenic inheritance (HP:0010982)2.00056864
101Abnormal platelet function (HP:0011869)1.99325868
102Impaired platelet aggregation (HP:0003540)1.99325868
103Complement deficiency (HP:0004431)1.99074831
104Keratoconjunctivitis sicca (HP:0001097)1.97849920
105Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97122435
106Vertigo (HP:0002321)1.97070058
107Hypergammaglobulinemia (HP:0010702)1.96101498
108Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.95695618
109Eosinophilia (HP:0001880)1.95290047
110T lymphocytopenia (HP:0005403)1.94091526
111Increased IgM level (HP:0003496)1.94033267
112Nonprogressive disorder (HP:0003680)1.93697975
113Reticulocytopenia (HP:0001896)1.93544711
114Abnormality of B cell number (HP:0010975)1.92546332
115Nasal polyposis (HP:0100582)1.91760289
116Amyloidosis (HP:0011034)1.90392015
117Neurofibrillary tangles (HP:0002185)1.90346914
118Acne (HP:0001061)1.89964364
119Glomerulopathy (HP:0100820)1.89316548
120Abnormality of T cell number (HP:0011839)1.88483378
121Joint hemorrhage (HP:0005261)1.88039111
122Panhypogammaglobulinemia (HP:0003139)1.87106230
123Sepsis (HP:0100806)1.87043073
124Abnormality of T cell physiology (HP:0011840)1.86585697
125Personality changes (HP:0000751)1.86462792
126Anhidrosis (HP:0000970)1.85199391
127Abnormality of the pericardium (HP:0001697)1.84768380
128Albinism (HP:0001022)1.84720647
129Mucopolysacchariduria (HP:0008155)1.81139412
130Urinary glycosaminoglycan excretion (HP:0003541)1.81139412
131Skin ulcer (HP:0200042)1.79975481
132Abnormality of the vasculature of the conjunctiva (HP:0008054)1.79277397

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.69678752
2IRAK43.34916854
3MAP3K143.10741422
4MAP4K12.82750051
5NME22.71429330
6TIE12.64080668
7TBK12.58573860
8TYK22.42319835
9TAOK22.34250211
10KDR2.30689326
11TGFBR22.29277218
12CLK12.16169742
13TAOK12.14521765
14KIT2.14018284
15IKBKB2.11208867
16RIPK42.10866193
17ERN12.08232787
18IKBKE2.06366060
19IRAK32.02432387
20ZAP701.96468144
21PRPF4B1.93674234
22TEC1.93395036
23MUSK1.91524631
24BTK1.80588076
25NLK1.69962459
26PIM21.57711901
27TXK1.51660333
28RPS6KA41.46361444
29DDR21.44102637
30EPHB11.43993536
31CSK1.43903162
32JAK31.39533908
33CSF1R1.38855249
34MAP3K131.37370947
35MAP2K31.33797158
36FES1.33194192
37CDC42BPA1.32116130
38PIM11.28958014
39RIPK11.26577884
40FGR1.26403281
41NTRK21.26316960
42TNK21.23708125
43CHUK1.15418562
44SYK1.13761521
45TRIB31.11376023
46HCK1.08987339
47LYN1.08660929
48PRKG21.08538493
49DYRK31.06280895
50GRK61.04179108
51GRK71.01703727
52MAP3K51.00298224
53JAK10.99437289
54PIK3CG0.98577696
55MAP3K110.97167059
56ADRBK20.92940989
57MOS0.86657684
58PRKD20.85730635
59LCK0.85478234
60YES10.82796242
61STK240.78973861
62MAP2K20.78474592
63TRPM70.77070651
64CDK90.75284865
65DMPK0.74737188
66STK100.74527240
67MAP3K10.71099309
68EIF2AK20.67461844
69LRRK20.67409890
70RPS6KA50.64370591
71BMPR20.64224929
72STK40.63490677
73MARK30.63244419
74MAP2K60.63237497
75NEK90.63196328
76PKN20.62817115
77MKNK20.62475716
78JAK20.62396741
79IRAK10.60701487
80RPS6KA60.60117285
81MATK0.59734061
82GRK10.59226326
83MAPKAPK20.58534926
84SIK30.57309987
85PTK2B0.54179237
86MAPK40.53370896
87ABL20.53298570
88TGFBR10.53228934
89PRKAA20.50882992
90MAP3K100.50154813
91PDK10.49439413
92PDPK10.49031240
93MYLK0.49016281
94MAPK70.48917748
95TTN0.48545897
96MKNK10.48334384
97PAK40.47922789
98CDK40.47915250
99ABL10.46866795
100PRKCD0.46840622
101HIPK20.46644868
102DYRK1B0.45624968
103MAP3K30.45532757
104ITK0.44599949
105VRK10.43903199
106MARK20.43567504
107RPS6KL10.42366825
108RPS6KC10.42366825
109CASK0.41706471
110PTK60.39779658
111ACVR1B0.38538138
112RPS6KA20.38279086
113TAOK30.36919069
114FLT30.36870275
115MAPK120.35564586
116CDK60.35346086
117CAMKK20.35180651
118TESK20.35014226
119MAP3K60.34651835
120KSR20.31145247
121ARAF0.29878281
122IRAK20.29646855
123GSK3A0.29473254
124FYN0.29264166
125EGFR0.28287563
126CCNB10.26970933
127PRKCQ0.25522884
128DAPK20.24828804

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.25195769
2Staphylococcus aureus infection_Homo sapiens_hsa051502.97469026
3Osteoclast differentiation_Homo sapiens_hsa043802.40362918
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.38379870
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.34479642
6Other glycan degradation_Homo sapiens_hsa005112.27312156
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.24473450
8Measles_Homo sapiens_hsa051622.15358836
9Pertussis_Homo sapiens_hsa051332.12836490
10Malaria_Homo sapiens_hsa051442.04036975
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.02329282
12Legionellosis_Homo sapiens_hsa051341.92404396
13B cell receptor signaling pathway_Homo sapiens_hsa046621.89817923
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89081783
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.87745936
16Allograft rejection_Homo sapiens_hsa053301.85450140
17Asthma_Homo sapiens_hsa053101.82997666
18Graft-versus-host disease_Homo sapiens_hsa053321.80293978
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78327952
20Tuberculosis_Homo sapiens_hsa051521.77544431
21Hematopoietic cell lineage_Homo sapiens_hsa046401.70917700
22Ribosome_Homo sapiens_hsa030101.69369173
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.69049220
24Shigellosis_Homo sapiens_hsa051311.67708705
25Herpes simplex infection_Homo sapiens_hsa051681.66562317
26TNF signaling pathway_Homo sapiens_hsa046681.58522340
27Toxoplasmosis_Homo sapiens_hsa051451.56540098
28Salmonella infection_Homo sapiens_hsa051321.54854588
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.51379165
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50801318
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50498105
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46118660
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.41435711
34Influenza A_Homo sapiens_hsa051641.40455177
35Lysosome_Homo sapiens_hsa041421.39413322
36Chemokine signaling pathway_Homo sapiens_hsa040621.35424684
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35267803
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32231964
39Apoptosis_Homo sapiens_hsa042101.29701600
40Rheumatoid arthritis_Homo sapiens_hsa053231.25051865
41Primary immunodeficiency_Homo sapiens_hsa053401.24930257
42Acute myeloid leukemia_Homo sapiens_hsa052211.21749978
43Antigen processing and presentation_Homo sapiens_hsa046121.16202512
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15537065
45Hepatitis B_Homo sapiens_hsa051611.15534561
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12946276
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12212938
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01987817
49Platelet activation_Homo sapiens_hsa046111.00915357
50Phagosome_Homo sapiens_hsa041450.99991343
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96902970
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94393679
53African trypanosomiasis_Homo sapiens_hsa051430.92223661
54Viral myocarditis_Homo sapiens_hsa054160.91931113
55Collecting duct acid secretion_Homo sapiens_hsa049660.91617757
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91551538
57Prion diseases_Homo sapiens_hsa050200.89658551
58Hepatitis C_Homo sapiens_hsa051600.87740076
59Sphingolipid metabolism_Homo sapiens_hsa006000.85972191
60Autoimmune thyroid disease_Homo sapiens_hsa053200.85840737
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82133512
62Small cell lung cancer_Homo sapiens_hsa052220.79221949
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78136004
64Amoebiasis_Homo sapiens_hsa051460.75983004
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72794555
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69319636
67Sulfur metabolism_Homo sapiens_hsa009200.69171824
68Chronic myeloid leukemia_Homo sapiens_hsa052200.69029347
69Epstein-Barr virus infection_Homo sapiens_hsa051690.68649281
70Bladder cancer_Homo sapiens_hsa052190.67662279
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67163527
72p53 signaling pathway_Homo sapiens_hsa041150.64018964
73Arachidonic acid metabolism_Homo sapiens_hsa005900.62504087
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61880863
75Pancreatic cancer_Homo sapiens_hsa052120.58150263
76Complement and coagulation cascades_Homo sapiens_hsa046100.58025795
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57893232
78Caffeine metabolism_Homo sapiens_hsa002320.57456212
79Notch signaling pathway_Homo sapiens_hsa043300.56102984
80T cell receptor signaling pathway_Homo sapiens_hsa046600.55708647
81DNA replication_Homo sapiens_hsa030300.53463211
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53160093
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51732980
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.50515973
85Vibrio cholerae infection_Homo sapiens_hsa051100.48972748
86Dorso-ventral axis formation_Homo sapiens_hsa043200.47829833
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.47072743
88VEGF signaling pathway_Homo sapiens_hsa043700.45872487
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.45548400
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45325299
91Base excision repair_Homo sapiens_hsa034100.44666496
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44415033
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.44327689
94GnRH signaling pathway_Homo sapiens_hsa049120.43383761
95Insulin resistance_Homo sapiens_hsa049310.42296475
96Prolactin signaling pathway_Homo sapiens_hsa049170.42148578
97Prostate cancer_Homo sapiens_hsa052150.40870661
98Type I diabetes mellitus_Homo sapiens_hsa049400.40800752
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39838967
100HTLV-I infection_Homo sapiens_hsa051660.39826806
101Type II diabetes mellitus_Homo sapiens_hsa049300.39302544
102Pyrimidine metabolism_Homo sapiens_hsa002400.37848768
103Ovarian steroidogenesis_Homo sapiens_hsa049130.37300312
104Homologous recombination_Homo sapiens_hsa034400.37189665
105Sulfur relay system_Homo sapiens_hsa041220.36981895
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36809371
107FoxO signaling pathway_Homo sapiens_hsa040680.36621471
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35553324
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35379050
110Olfactory transduction_Homo sapiens_hsa047400.34637495
111Pathways in cancer_Homo sapiens_hsa052000.34252208
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34138303
113Viral carcinogenesis_Homo sapiens_hsa052030.33730702
114HIF-1 signaling pathway_Homo sapiens_hsa040660.31936456
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30932466
116Systemic lupus erythematosus_Homo sapiens_hsa053220.30722577
117Ether lipid metabolism_Homo sapiens_hsa005650.29524232
118Histidine metabolism_Homo sapiens_hsa003400.29295749
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28441300
120MAPK signaling pathway_Homo sapiens_hsa040100.28003280
121Endocytosis_Homo sapiens_hsa041440.25638253
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25468873
123Non-small cell lung cancer_Homo sapiens_hsa052230.23493064
124Estrogen signaling pathway_Homo sapiens_hsa049150.19753718
125Renal cell carcinoma_Homo sapiens_hsa052110.19309556

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