HLF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)6.79522516
2very-low-density lipoprotein particle assembly (GO:0034379)6.40738120
3regulation of fibrinolysis (GO:0051917)6.14165062
4plasma lipoprotein particle assembly (GO:0034377)5.79973400
5regulation of protein activation cascade (GO:2000257)5.79350353
6regulation of complement activation (GO:0030449)5.67992071
7low-density lipoprotein particle remodeling (GO:0034374)5.60513530
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.57779054
9protein carboxylation (GO:0018214)5.53863719
10peptidyl-glutamic acid carboxylation (GO:0017187)5.53863719
11intestinal cholesterol absorption (GO:0030299)5.43408131
12synaptic vesicle docking involved in exocytosis (GO:0016081)5.27386489
13protein-lipid complex assembly (GO:0065005)5.26971062
14synaptic vesicle maturation (GO:0016188)5.26142277
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.14924662
16L-phenylalanine catabolic process (GO:0006559)5.14924662
17regulation of short-term neuronal synaptic plasticity (GO:0048172)5.13868912
18synaptic vesicle exocytosis (GO:0016079)5.01775746
19glutamate secretion (GO:0014047)5.01562007
20cholesterol efflux (GO:0033344)4.98805034
21blood coagulation, intrinsic pathway (GO:0007597)4.95023000
22plasma lipoprotein particle remodeling (GO:0034369)4.86470043
23protein-lipid complex remodeling (GO:0034368)4.86470043
24macromolecular complex remodeling (GO:0034367)4.86470043
25locomotory exploration behavior (GO:0035641)4.83774846
26regulation of apoptotic cell clearance (GO:2000425)4.81006294
27regulation of cholesterol esterification (GO:0010872)4.79119327
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.78788564
29L-phenylalanine metabolic process (GO:0006558)4.78788564
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.75104192
31vocalization behavior (GO:0071625)4.70187082
32neurotransmitter-gated ion channel clustering (GO:0072578)4.57233311
33plasma lipoprotein particle organization (GO:0071827)4.47574302
34regulation of glutamate receptor signaling pathway (GO:1900449)4.45416750
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.36353958
36regulation of synaptic vesicle exocytosis (GO:2000300)4.35578138
37neurotransmitter secretion (GO:0007269)4.31317588
38protein-lipid complex subunit organization (GO:0071825)4.26688123
39high-density lipoprotein particle remodeling (GO:0034375)4.25843347
40negative regulation of protein activation cascade (GO:2000258)4.23409266
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.13026586
42positive regulation of dendritic spine morphogenesis (GO:0061003)4.11222475
43reverse cholesterol transport (GO:0043691)4.06117845
44regulation of long-term neuronal synaptic plasticity (GO:0048169)4.04292457
45regulation of synapse structural plasticity (GO:0051823)4.00728355
46complement activation, alternative pathway (GO:0006957)3.97853956
47regulation of plasminogen activation (GO:0010755)3.96841567
48plasma lipoprotein particle clearance (GO:0034381)3.96426515
49negative regulation of cytosolic calcium ion concentration (GO:0051481)3.96304022
50negative regulation of cholesterol transport (GO:0032375)3.95248208
51negative regulation of sterol transport (GO:0032372)3.95248208
52protein localization to synapse (GO:0035418)3.94840645
53positive regulation of membrane potential (GO:0045838)3.94527600
54regulation of bile acid biosynthetic process (GO:0070857)3.94356152
55triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.93987095
56regulation of synaptic vesicle transport (GO:1902803)3.93896088
57regulation of cholesterol homeostasis (GO:2000188)3.90490729
58neuronal action potential propagation (GO:0019227)3.85454798
59cellular potassium ion homeostasis (GO:0030007)3.83950441
60regulation of neuronal synaptic plasticity (GO:0048168)3.80829496
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.79192818
62ionotropic glutamate receptor signaling pathway (GO:0035235)3.78992510
63glutamate receptor signaling pathway (GO:0007215)3.74365171
64synaptic transmission, glutamatergic (GO:0035249)3.71101194
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.69666532
66regulation of excitatory postsynaptic membrane potential (GO:0060079)3.68416082
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67779855
68response to histamine (GO:0034776)3.66405534
69gamma-aminobutyric acid transport (GO:0015812)3.62578253
70neuron-neuron synaptic transmission (GO:0007270)3.59164584
71sodium ion export (GO:0071436)3.58391459
72long-term memory (GO:0007616)3.58384766
73neurotransmitter transport (GO:0006836)3.54133960
74C4-dicarboxylate transport (GO:0015740)3.53504959
75negative regulation of complement activation (GO:0045916)3.52016925
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50963820
77intestinal absorption (GO:0050892)3.50650381
78regulation of postsynaptic membrane potential (GO:0060078)3.50060146
79positive regulation of neurotransmitter secretion (GO:0001956)3.49188194
80regulation of cholesterol biosynthetic process (GO:0045540)3.45573730
81central nervous system myelination (GO:0022010)3.44307425
82axon ensheathment in central nervous system (GO:0032291)3.44307425
83positive regulation of neurotransmitter transport (GO:0051590)3.42322522
84gamma-aminobutyric acid signaling pathway (GO:0007214)3.41785021
85embryonic retina morphogenesis in camera-type eye (GO:0060059)3.41753210
86prepulse inhibition (GO:0060134)3.37523140
87exploration behavior (GO:0035640)3.36388870
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.36209301
89negative regulation of sodium ion transport (GO:0010766)3.35354333
90regulation of synaptic transmission, glutamatergic (GO:0051966)3.33370381
91long-term synaptic potentiation (GO:0060291)3.33355633
92regulation of neurotransmitter levels (GO:0001505)3.31258679
93negative regulation of dendrite morphogenesis (GO:0050774)3.27164522
94diacylglycerol metabolic process (GO:0046339)3.26808992
95cerebellar Purkinje cell differentiation (GO:0021702)3.25766833
96regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.23030055
97membrane hyperpolarization (GO:0060081)3.21817840
98neuromuscular process controlling posture (GO:0050884)3.20507476
99regulation of voltage-gated calcium channel activity (GO:1901385)3.20149313
100positive regulation of hemostasis (GO:1900048)3.19587019
101positive regulation of blood coagulation (GO:0030194)3.19587019
102positive regulation of steroid metabolic process (GO:0045940)3.18453226
103striatum development (GO:0021756)3.15015513
104regulation of humoral immune response (GO:0002920)3.14567482
105postsynaptic membrane organization (GO:0001941)3.14146707
106positive regulation of synapse maturation (GO:0090129)3.13406545
107regulation of synapse maturation (GO:0090128)3.12636303
108regulation of synaptic plasticity (GO:0048167)3.12411288
109fibrinolysis (GO:0042730)3.11968615
110neuron cell-cell adhesion (GO:0007158)3.11957620
111behavioral response to cocaine (GO:0048148)3.09667296
112protein activation cascade (GO:0072376)3.09069027
113acute-phase response (GO:0006953)3.08779744
114regulation of neurotransmitter secretion (GO:0046928)3.08074948
115positive regulation of extracellular matrix organization (GO:1903055)3.07481628
116cholesterol transport (GO:0030301)3.06225155
117sterol transport (GO:0015918)3.06225155
118cerebellar granule cell differentiation (GO:0021707)3.06112445
119lipoprotein metabolic process (GO:0042157)3.03211194
120ethanol oxidation (GO:0006069)3.00323949
121positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.99906054
122positive regulation of synaptic transmission, GABAergic (GO:0032230)2.99384537
123positive regulation of lipoprotein lipase activity (GO:0051006)2.98894011
124positive regulation of triglyceride lipase activity (GO:0061365)2.98894011
125triglyceride homeostasis (GO:0070328)2.98500350
126acylglycerol homeostasis (GO:0055090)2.98500350
127auditory behavior (GO:0031223)2.98169978
128lung epithelium development (GO:0060428)2.97947043
129activation of protein kinase A activity (GO:0034199)2.97365921
130cholesterol homeostasis (GO:0042632)2.95366521
131negative regulation of blood coagulation (GO:0030195)2.95306193
132negative regulation of hemostasis (GO:1900047)2.95306193
133regulation of neurotransmitter transport (GO:0051588)2.95291639
134positive regulation of respiratory burst (GO:0060267)2.94559964
135layer formation in cerebral cortex (GO:0021819)2.94044553
136sterol homeostasis (GO:0055092)2.92121635
137positive regulation of coagulation (GO:0050820)2.91967578
138phospholipid efflux (GO:0033700)2.91649713
139low-density lipoprotein particle clearance (GO:0034383)2.91162104
140visual learning (GO:0008542)2.89890275
141positive regulation of fatty acid biosynthetic process (GO:0045723)2.89751078
142synaptic vesicle endocytosis (GO:0048488)2.89471886
143definitive hemopoiesis (GO:0060216)2.88903149
144sodium ion homeostasis (GO:0055078)2.88856502
145proline metabolic process (GO:0006560)2.88786742
146positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87761389
147cell communication by electrical coupling (GO:0010644)2.86778960
148drinking behavior (GO:0042756)2.86084129
149aromatic amino acid family catabolic process (GO:0009074)2.83383348
150mechanosensory behavior (GO:0007638)2.83181295
151membrane depolarization (GO:0051899)2.82838725
152regulation of vesicle fusion (GO:0031338)2.80586924
153regulation of dendritic spine morphogenesis (GO:0061001)2.79680169
154positive regulation of synaptic transmission (GO:0050806)2.77665905
155presynaptic membrane assembly (GO:0097105)2.76562507
156learning (GO:0007612)2.76489617
157dicarboxylic acid biosynthetic process (GO:0043650)2.73945840
158dendritic spine morphogenesis (GO:0060997)2.73887233
159visual behavior (GO:0007632)2.73055374
160cellular sodium ion homeostasis (GO:0006883)2.72262162
161long term synaptic depression (GO:0060292)2.71009736
162regulation of female receptivity (GO:0045924)2.67558360
163potassium ion homeostasis (GO:0055075)2.66586322
164glutamate metabolic process (GO:0006536)2.65690812
165retinal rod cell development (GO:0046548)2.65281010
166membrane depolarization during action potential (GO:0086010)2.65054876
167behavioral defense response (GO:0002209)2.64375723
168behavioral fear response (GO:0001662)2.64375723
169synaptic transmission (GO:0007268)2.64019321
170negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.63575404
171response to auditory stimulus (GO:0010996)2.62729518
172proline transport (GO:0015824)2.61289803
173negative regulation of synaptic transmission, GABAergic (GO:0032229)2.61068252
174positive regulation of dendritic spine development (GO:0060999)2.59586900
175relaxation of smooth muscle (GO:0044557)2.59117449
176negative regulation of dendrite development (GO:2000171)2.58554278
177transmission of nerve impulse (GO:0019226)2.58135308
178neuromuscular process controlling balance (GO:0050885)2.57518877

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.29897220
2* FOXA2_19822575_ChIP-Seq_HepG2_Human3.62633757
3* GBX2_23144817_ChIP-Seq_PC3_Human3.36567757
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78514193
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75718826
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.73887768
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66250341
8DROSHA_22980978_ChIP-Seq_HELA_Human2.59965534
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.57425180
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48503051
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36481990
12REST_21632747_ChIP-Seq_MESCs_Mouse2.34497426
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33934302
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32853356
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28869136
16* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28869136
17* HNF4A_19822575_ChIP-Seq_HepG2_Human2.28357147
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21924105
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18191897
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09142307
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07626008
22SCL_19346495_ChIP-Seq_HPC-7_Human2.02507422
23TAF15_26573619_Chip-Seq_HEK293_Human2.00278538
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.98524452
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98258495
26* EZH2_27294783_Chip-Seq_ESCs_Mouse1.97967795
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.94008355
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85248275
29* RNF2_27304074_Chip-Seq_ESCs_Mouse1.80560459
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80280420
31AR_21572438_ChIP-Seq_LNCaP_Human1.79413168
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77509587
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77165825
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.75975335
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75878231
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.74886800
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.71814100
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.68092781
39CTNNB1_20460455_ChIP-Seq_HCT116_Human1.63428481
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.61742969
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61541718
42TCF4_18268006_ChIP-ChIP_LS174T_Human1.61124597
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53742180
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52084196
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.49833460
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.47574883
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46027444
48ZNF263_19887448_ChIP-Seq_K562_Human1.43493916
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41963656
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40481557
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39683449
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38744674
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38521404
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37439434
55P300_19829295_ChIP-Seq_ESCs_Human1.37421112
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.34220790
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32956642
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32183156
59* RXR_22158963_ChIP-Seq_LIVER_Mouse1.31740987
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29219332
61AR_25329375_ChIP-Seq_VCAP_Human1.29019557
62* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25230581
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25017179
64FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23411068
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.19778911
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19554738
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18102681
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17057018
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.16461983
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.15512530
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14758591
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13401031
73* SOX2_21211035_ChIP-Seq_LN229_Gbm1.12127541
74GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.10940046
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10202697
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.10199564
77* CLOCK_20551151_ChIP-Seq_293T_Human1.09119050
78* RING1B_27294783_Chip-Seq_ESCs_Mouse1.07636600
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07429342
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07339463
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06050173
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05605865
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05011605
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04478871
85* SMAD3_21741376_ChIP-Seq_EPCs_Human1.03906092
86* AR_19668381_ChIP-Seq_PC3_Human1.03398234
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03174870
88IGF1R_20145208_ChIP-Seq_DFB_Human1.01762863
89* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00755013
90RUNX_20019798_ChIP-Seq_JUKART_Human1.00728619
91ZNF274_21170338_ChIP-Seq_K562_Hela1.00554291
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00514502
93* STAT3_23295773_ChIP-Seq_U87_Human0.99296712
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98782618
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98731414
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98548102
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97576573
98BCAT_22108803_ChIP-Seq_LS180_Human0.97252801
99NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96832695
100TP53_16413492_ChIP-PET_HCT116_Human0.96379376
101* LXR_22158963_ChIP-Seq_LIVER_Mouse0.96302720
102GATA1_19941827_ChIP-Seq_MEL_Mouse0.95929356
103ESR1_21235772_ChIP-Seq_MCF-7_Human0.95422326
104CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94314378
105TCF4_23295773_ChIP-Seq_U87_Human0.93866324
106SMAD1_18555785_Chip-Seq_ESCs_Mouse0.92947104
107GATA2_21666600_ChIP-Seq_HMVEC_Human0.92540084
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91694665
109FUS_26573619_Chip-Seq_HEK293_Human0.89851203
110POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89336799
111* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89127489
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88147860
113NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87910004
114RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87875163
115CBP_20019798_ChIP-Seq_JUKART_Human0.87019752
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87019752
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.86515889
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.86106324
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85197841
120* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84607426
121YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84231663
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83986527
123RUNX1_27457419_Chip-Seq_LIVER_Mouse0.83981164
124WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83015868
125NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82595465
126* KDM2B_26808549_Chip-Seq_K562_Human0.82075487
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.81926550
128RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81452869
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81314567
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.81241343
131KLF4_18555785_Chip-Seq_ESCs_Mouse0.81177333
132* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81090896
133CBX2_27304074_Chip-Seq_ESCs_Mouse0.80946246
134* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80413649
135PU1_27457419_Chip-Seq_LIVER_Mouse0.80231249
136PRDM14_20953172_ChIP-Seq_ESCs_Human0.79948004
137* RXR_22108803_ChIP-Seq_LS180_Human0.79480644
138MYC_19915707_ChIP-ChIP_AK7_Human0.79020249
139FLI1_27457419_Chip-Seq_LIVER_Mouse0.77941389
140* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77247905
141DPY_21335234_ChIP-Seq_ESCs_Mouse0.76942805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.62792968
2MP0003122_maternal_imprinting5.55241579
3MP0003880_abnormal_central_pattern4.02293207
4MP0003195_calcinosis3.91774517
5MP0003635_abnormal_synaptic_transmissio3.70596747
6MP0002822_catalepsy3.47580319
7MP0009745_abnormal_behavioral_response3.28465611
8MP0003123_paternal_imprinting3.24029155
9MP0002064_seizures2.89756272
10MP0002063_abnormal_learning/memory/cond2.85747470
11MP0009046_muscle_twitch2.77212672
12MP0001968_abnormal_touch/_nociception2.67576058
13MP0004270_analgesia2.59904034
14MP0001501_abnormal_sleep_pattern2.52550633
15MP0001486_abnormal_startle_reflex2.50981416
16MP0002272_abnormal_nervous_system2.47028424
17MP0002572_abnormal_emotion/affect_behav2.46891403
18MP0005646_abnormal_pituitary_gland2.44100074
19MP0008875_abnormal_xenobiotic_pharmacok2.34070769
20MP0005423_abnormal_somatic_nervous2.26178626
21MP0005551_abnormal_eye_electrophysiolog2.23530387
22MP0003172_abnormal_lysosome_physiology2.22248526
23MP0008569_lethality_at_weaning2.21203894
24MP0001984_abnormal_olfaction2.09077574
25MP0001188_hyperpigmentation2.07467776
26MP0000566_synostosis2.02877605
27MP0005085_abnormal_gallbladder_physiolo1.95356973
28MP0001502_abnormal_circadian_rhythm1.91170376
29MP0003879_abnormal_hair_cell1.88319309
30MP0005360_urolithiasis1.86801133
31MP0003121_genomic_imprinting1.84393862
32MP0005365_abnormal_bile_salt1.82436312
33MP0002090_abnormal_vision1.82371046
34MP0002736_abnormal_nociception_after1.79738920
35MP0002139_abnormal_hepatobiliary_system1.79107951
36MP0002734_abnormal_mechanical_nocicepti1.77770980
37MP0002067_abnormal_sensory_capabilities1.73406728
38MP0002909_abnormal_adrenal_gland1.62292537
39MP0002089_abnormal_postnatal_growth/wei1.62263740
40MP0002557_abnormal_social/conspecific_i1.60487259
41MP0000920_abnormal_myelination1.56288759
42MP0008872_abnormal_physiological_respon1.53480822
43MP0003633_abnormal_nervous_system1.52853150
44MP0010329_abnormal_lipoprotein_level1.47303991
45MP0008874_decreased_physiological_sensi1.47270527
46MP0003075_altered_response_to1.47033220
47MP0005386_behavior/neurological_phenoty1.45169474
48MP0004924_abnormal_behavior1.45169474
49MP0004885_abnormal_endolymph1.43311041
50MP0003183_abnormal_peptide_metabolism1.41479118
51MP0001915_intracranial_hemorrhage1.29194621
52MP0004147_increased_porphyrin_level1.28023127
53MP0005535_abnormal_body_temperature1.21688096
54MP0001970_abnormal_pain_threshold1.19717896
55MP0004811_abnormal_neuron_physiology1.19659318
56MP0003868_abnormal_feces_composition1.18866733
57MP0010368_abnormal_lymphatic_system1.18853271
58MP0009780_abnormal_chondrocyte_physiolo1.18049764
59MP0000604_amyloidosis1.17309072
60MP0003632_abnormal_nervous_system1.16815975
61MP0005058_abnormal_lysosome_morphology1.12991214
62MP0001440_abnormal_grooming_behavior1.12711086
63MP0002733_abnormal_thermal_nociception1.10979574
64MP0000639_abnormal_adrenal_gland1.09825174
65MP0005409_darkened_coat_color1.08857769
66MP0001905_abnormal_dopamine_level1.08428474
67MP0000609_abnormal_liver_physiology1.08140629
68MP0004130_abnormal_muscle_cell1.07489071
69MP0004142_abnormal_muscle_tone1.07110464
70MP0004510_myositis1.06113634
71MP0005408_hypopigmentation1.04489932
72MP0003631_nervous_system_phenotype1.02839660
73MP0002066_abnormal_motor_capabilities/c1.02652390
74MP0002184_abnormal_innervation1.00864594
75MP0008961_abnormal_basal_metabolism1.00594711
76MP0005167_abnormal_blood-brain_barrier0.99111468
77MP0002229_neurodegeneration0.94952434
78MP0005636_abnormal_mineral_homeostasis0.93928426
79MP0005584_abnormal_enzyme/coenzyme_acti0.92220219
80MP0003011_delayed_dark_adaptation0.90595500
81MP0005670_abnormal_white_adipose0.90227270
82MP0002882_abnormal_neuron_morphology0.89471617
83MP0005332_abnormal_amino_acid0.89174760
84MP0006054_spinal_hemorrhage0.88087602
85MP0002069_abnormal_eating/drinking_beha0.86737480
86MP0004043_abnormal_pH_regulation0.86605278
87MP0002876_abnormal_thyroid_physiology0.86590364
88MP0003329_amyloid_beta_deposits0.84779597
89MP0006292_abnormal_olfactory_placode0.84165877
90MP0004085_abnormal_heartbeat0.83228810
91MP0005379_endocrine/exocrine_gland_phen0.81850747
92MP0002078_abnormal_glucose_homeostasis0.81010994
93MP0002118_abnormal_lipid_homeostasis0.80765754
94MP0003690_abnormal_glial_cell0.79686559
95MP0004742_abnormal_vestibular_system0.79332788
96MP0004215_abnormal_myocardial_fiber0.78773236
97MP0002971_abnormal_brown_adipose0.78638788
98MP0005084_abnormal_gallbladder_morpholo0.77153889
99MP0000955_abnormal_spinal_cord0.76493173
100MP0003638_abnormal_response/metabolism_0.76405645
101MP0001664_abnormal_digestion0.76241130
102MP0003252_abnormal_bile_duct0.75665843
103MP0004036_abnormal_muscle_relaxation0.74598658
104MP0000003_abnormal_adipose_tissue0.73838424
105MP0001270_distended_abdomen0.72829018
106MP0001765_abnormal_ion_homeostasis0.72552869
107MP0005464_abnormal_platelet_physiology0.72433110
108MP0005448_abnormal_energy_balance0.71963641
109MP0002132_abnormal_respiratory_system0.71376429
110MP0004019_abnormal_vitamin_homeostasis0.71201328
111MP0002735_abnormal_chemical_nociception0.71172732
112MP0009840_abnormal_foam_cell0.70623268
113MP0001986_abnormal_taste_sensitivity0.69924465
114MP0001177_atelectasis0.69701928
115MP0003656_abnormal_erythrocyte_physiolo0.69562636
116MP0005166_decreased_susceptibility_to0.69556778
117MP0001529_abnormal_vocalization0.69205972
118MP0005253_abnormal_eye_physiology0.68612472
119MP0000631_abnormal_neuroendocrine_gland0.68449044
120MP0001756_abnormal_urination0.68172655
121MP0001666_abnormal_nutrient_absorption0.67317603
122MP0002638_abnormal_pupillary_reflex0.67063257
123MP0001764_abnormal_homeostasis0.67007437
124MP0000013_abnormal_adipose_tissue0.66666676
125MP0003953_abnormal_hormone_level0.66371983
126MP0000230_abnormal_systemic_arterial0.65534964
127MP0003943_abnormal_hepatobiliary_system0.65363520
128MP0005451_abnormal_body_composition0.65142866
129MP0005410_abnormal_fertilization0.65009565
130MP0004484_altered_response_of0.64616065
131MP0002254_reproductive_system_inflammat0.63448306
132MP0002160_abnormal_reproductive_system0.62127219
133MP0009642_abnormal_blood_homeostasis0.61565252
134MP0001963_abnormal_hearing_physiology0.61002399
135MP0005174_abnormal_tail_pigmentation0.60899388
136MP0000751_myopathy0.60711758
137MP0000598_abnormal_liver_morphology0.58575626
138MP0003634_abnormal_glial_cell0.58183572

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.28880138
2Complement deficiency (HP:0004431)5.64134108
3Joint hemorrhage (HP:0005261)5.62718158
4Hypobetalipoproteinemia (HP:0003563)5.41384322
5Epileptic encephalopathy (HP:0200134)5.31830437
6Myokymia (HP:0002411)5.02137363
7Febrile seizures (HP:0002373)4.87772900
8Abnormality of the common coagulation pathway (HP:0010990)4.78504638
9Congenital stationary night blindness (HP:0007642)4.66703737
10Focal seizures (HP:0007359)4.53753995
11Visual hallucinations (HP:0002367)4.49630696
12Hyperventilation (HP:0002883)4.46241822
13Glomerulonephritis (HP:0000099)4.15237639
14Abnormality of complement system (HP:0005339)3.95469293
15Progressive cerebellar ataxia (HP:0002073)3.95068153
16Hypercholesterolemia (HP:0003124)3.90369344
17Xanthomatosis (HP:0000991)3.88539330
18Absence seizures (HP:0002121)3.74260617
19Gaze-evoked nystagmus (HP:0000640)3.71241863
20Broad-based gait (HP:0002136)3.66584783
21Small epiphyses (HP:0010585)3.66132703
22Acanthocytosis (HP:0001927)3.57845613
23Poor eye contact (HP:0000817)3.51033327
24Systemic lupus erythematosus (HP:0002725)3.37996993
25Atonic seizures (HP:0010819)3.37596148
26Scanning speech (HP:0002168)3.35004749
27Genetic anticipation (HP:0003743)3.31912899
28Epidermoid cyst (HP:0200040)3.31018897
29Menorrhagia (HP:0000132)3.27490868
30Dialeptic seizures (HP:0011146)3.26628757
31Impaired social interactions (HP:0000735)3.22457940
32Abnormal social behavior (HP:0012433)3.22457940
33Anxiety (HP:0000739)3.19519936
34Generalized tonic-clonic seizures (HP:0002069)3.18390632
35Broad alveolar ridges (HP:0000187)3.17288317
36Dysdiadochokinesis (HP:0002075)3.15820090
37Dysmetric saccades (HP:0000641)3.13626101
38Status epilepticus (HP:0002133)3.13595809
39Hypolipoproteinemia (HP:0010981)3.11989223
40Hemorrhage of the eye (HP:0011885)3.05186104
41Abnormality of carpal bone ossification (HP:0006257)3.03100205
42Depression (HP:0000716)3.01590799
43Action tremor (HP:0002345)2.98804123
44Vascular calcification (HP:0004934)2.93699553
45Pancreatic islet-cell hyperplasia (HP:0004510)2.85836255
46Abnormality of aromatic amino acid family metabolism (HP:0004338)2.85368554
47Annular pancreas (HP:0001734)2.81694074
48Postural instability (HP:0002172)2.80571186
49Stereotypic behavior (HP:0000733)2.74901943
50Focal dystonia (HP:0004373)2.74514577
51Fair hair (HP:0002286)2.74497210
52Torticollis (HP:0000473)2.73846799
53Abnormality of monocarboxylic acid metabolism (HP:0010996)2.73167765
54Truncal ataxia (HP:0002078)2.73056202
55Abnormal tarsal ossification (HP:0008369)2.71560919
56Abnormality of macular pigmentation (HP:0008002)2.69858959
57Impaired smooth pursuit (HP:0007772)2.64848087
58Abnormality of the intrinsic pathway (HP:0010989)2.58000375
59Epiphyseal dysplasia (HP:0002656)2.57472906
60Impaired vibration sensation in the lower limbs (HP:0002166)2.57366553
61Central scotoma (HP:0000603)2.57355690
62Craniofacial dystonia (HP:0012179)2.56481464
63Hypoglycemic coma (HP:0001325)2.53454017
64Alacrima (HP:0000522)2.53125704
65Hepatoblastoma (HP:0002884)2.51366013
66Abnormality of the periventricular white matter (HP:0002518)2.51073366
67Cardiovascular calcification (HP:0011915)2.50139688
68Dysmetria (HP:0001310)2.49553189
69Conjugated hyperbilirubinemia (HP:0002908)2.47954779
70Gingival bleeding (HP:0000225)2.46979498
71Generalized hypopigmentation of hair (HP:0011358)2.45777615
72Purpura (HP:0000979)2.45660008
73Flat acetabular roof (HP:0003180)2.43509192
74Mitral stenosis (HP:0001718)2.43440534
75Broad palm (HP:0001169)2.43299965
76Hemiplegia (HP:0002301)2.40913708
77Hyperlipoproteinemia (HP:0010980)2.40340308
78Abnormality of the lumbar spine (HP:0100712)2.39832529
79Decreased central vision (HP:0007663)2.39045067
80Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.38610077
81Urinary bladder sphincter dysfunction (HP:0002839)2.38315214
82Spontaneous abortion (HP:0005268)2.38155854
83Intention tremor (HP:0002080)2.36487328
84Asymmetry of the thorax (HP:0001555)2.34887664
85Abnormal eating behavior (HP:0100738)2.34735117
86Abnormality of ocular smooth pursuit (HP:0000617)2.34689752
87Nonprogressive disorder (HP:0003680)2.33840620
88Abnormality of the nasal septum (HP:0000419)2.32448216
89Papilledema (HP:0001085)2.31300925
90Arthropathy (HP:0003040)2.29748520
91Progressive inability to walk (HP:0002505)2.29421255
92Skin nodule (HP:0200036)2.29093234
93Fat malabsorption (HP:0002630)2.24249159
94Abnormal hand bone ossification (HP:0010660)2.24052928
95Hypophosphatemic rickets (HP:0004912)2.23687051
96Bradykinesia (HP:0002067)2.23501793
97Neurofibrillary tangles (HP:0002185)2.22995090
98Impaired vibratory sensation (HP:0002495)2.16472173
99Pigmentary retinal degeneration (HP:0001146)2.16424818
100Abnormal ossification of hand bones (HP:0005921)2.15170404
101Diastasis recti (HP:0001540)2.14560896
102Delayed CNS myelination (HP:0002188)2.13908996
103Potter facies (HP:0002009)2.13785570
104Facial shape deformation (HP:0011334)2.13785570
105Abnormal rod and cone electroretinograms (HP:0008323)2.13653735
106Inability to walk (HP:0002540)2.13474006
107Ankle clonus (HP:0011448)2.12804048
108Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09625595
109Hypoglycemic seizures (HP:0002173)2.08923305
110Abnormality of the wing of the ilium (HP:0011867)2.07213764
111Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.06989665
112Nephritis (HP:0000123)2.06696329
113Blue irides (HP:0000635)2.06400890
114Drooling (HP:0002307)2.05837781
115Excessive salivation (HP:0003781)2.05837781
116Agitation (HP:0000713)2.04738333
117Protruding tongue (HP:0010808)2.04659001
118Prolonged bleeding time (HP:0003010)2.00501942
119Flared iliac wings (HP:0002869)1.98717119
120Thrombophlebitis (HP:0004418)1.98037190
121Abnormality of the pancreatic islet cells (HP:0006476)1.95408277
122Abnormality of endocrine pancreas physiology (HP:0012093)1.95408277
123Gout (HP:0001997)1.95405220
124Poikilocytosis (HP:0004447)1.95191185
125Epileptiform EEG discharges (HP:0011182)1.94427208
126Hyperinsulinemic hypoglycemia (HP:0000825)1.94344732
127Abnormality of pain sensation (HP:0010832)1.94078357
128Impaired pain sensation (HP:0007328)1.94078357
129Ketosis (HP:0001946)1.92758430
130Abnormality of saccadic eye movements (HP:0000570)1.92530135
131Enlarged kidneys (HP:0000105)1.92047819
132Irregular epiphyses (HP:0010582)1.90864804
133Decreased lacrimation (HP:0000633)1.90635627
134Hemiparesis (HP:0001269)1.90430895
135Deep venous thrombosis (HP:0002625)1.89382295
136Vaginal fistula (HP:0004320)1.87688881
137Bronchomalacia (HP:0002780)1.86788972
138Intrahepatic cholestasis (HP:0001406)1.84671537
139Psychosis (HP:0000709)1.83009753
140Mutism (HP:0002300)1.80764921
141Increased serum pyruvate (HP:0003542)1.80709848
142Limb ataxia (HP:0002070)1.80587323
143Abnormal EKG (HP:0003115)1.80534103
144Spinal canal stenosis (HP:0003416)1.79973105
145EEG with generalized epileptiform discharges (HP:0011198)1.79468570
146Hypothermia (HP:0002045)1.78769782
147Supranuclear gaze palsy (HP:0000605)1.77205620
148Abnormality of glycolysis (HP:0004366)1.76377756
149Generalized myoclonic seizures (HP:0002123)1.76068971
150Rickets (HP:0002748)1.75400529
151Osteomalacia (HP:0002749)1.75141093
152Severe visual impairment (HP:0001141)1.74047336
153Abnormality of the heme biosynthetic pathway (HP:0010472)1.73951143
154Acute lymphatic leukemia (HP:0006721)1.73169461
155Ventricular fibrillation (HP:0001663)1.72762196
156Rigidity (HP:0002063)1.72321622
157Severe global developmental delay (HP:0011344)1.72144031
158Clumsiness (HP:0002312)1.69292974
159Amblyopia (HP:0000646)1.69026247
160Akinesia (HP:0002304)1.68067979
161Cerebral inclusion bodies (HP:0100314)1.66414438
162Hypoalphalipoproteinemia (HP:0003233)1.66373953
163Prolonged QT interval (HP:0001657)1.65487756
164Dyskinesia (HP:0100660)1.65432520
165Papillary thyroid carcinoma (HP:0002895)1.65308106
166Absent epiphyses (HP:0010577)1.65236336
167Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65236336
168Prolonged partial thromboplastin time (HP:0003645)1.65020294
169Absent speech (HP:0001344)1.64777381
170Neonatal onset (HP:0003623)1.64193964
171Absent rod-and cone-mediated responses on ERG (HP:0007688)1.63846791
172Pulmonary embolism (HP:0002204)1.63237335
173Choreoathetosis (HP:0001266)1.62048938
174Gait ataxia (HP:0002066)1.59239093
175Abnormality of the lower motor neuron (HP:0002366)1.58368932
176Abnormal gallbladder physiology (HP:0012438)1.55737569
177Cholecystitis (HP:0001082)1.55737569
178Diplopia (HP:0000651)1.55477720
179Abnormality of binocular vision (HP:0011514)1.55477720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR44.23993251
2EPHA44.09467242
3FGFR34.03178844
4NTRK33.15180491
5CDK193.12244992
6TNIK3.10322404
7MAP3K42.94441420
8MAP2K72.90494317
9MAP3K92.83370492
10WNK42.78516953
11MAP3K122.46799052
12DAPK22.44455403
13TYRO32.42878924
14FGFR22.41659250
15MAP2K42.37878550
16ICK2.24822408
17CAMKK12.14861955
18PIK3CA2.11663002
19AKT31.96400626
20CASK1.96095738
21WNK11.94805211
22CDK121.90114584
23DAPK11.87953895
24CAMKK21.87819378
25MUSK1.85534217
26LATS11.84319279
27MINK11.82265754
28RIPK41.80499309
29LATS21.79973662
30SGK21.79802011
31TNK21.78694549
32KIT1.73786196
33FES1.61794397
34CAMK11.55138098
35PINK11.54514218
36FGFR11.50435424
37MAP3K131.45424538
38SGK31.42807351
39SGK4941.42171968
40SGK2231.42171968
41MAP2K31.40693987
42STK381.38899490
43CCNB11.34830389
44PDGFRA1.32246259
45PRKD31.26674767
46NTRK21.23569485
47TIE11.21314300
48KSR21.20974087
49MAPKAPK51.19708847
50TAOK11.14372477
51PAK61.14359968
52CDK51.13082549
53PDK11.10402087
54OXSR11.07078463
55MAP3K71.06816394
56PRKAA21.02000828
57PRKCH0.97895951
58SIK20.97438472
59PRPF4B0.94176370
60RPS6KB10.89171563
61MAP2K60.88104967
62RIPK10.87821859
63RET0.87312118
64GRK50.84148009
65MAP3K60.81641394
66CAMK40.81450083
67PRKD20.80775803
68EEF2K0.80573428
69BCKDK0.80496533
70FLT30.80369696
71PRKCG0.77949376
72MATK0.75831158
73CSNK1E0.74688316
74STK390.74647305
75STK110.74386907
76NTRK10.72841719
77ALK0.72828112
78MAP3K10.72504610
79PDPK10.72232112
80MAP3K20.69603022
81MAPK110.67617635
82CAMK1G0.66137779
83SIK30.65898788
84MAPK100.65642166
85CAMK2A0.64628442
86MAPK130.64468712
87BRSK10.62595857
88MAPK120.62472049
89NEK60.62350629
90DYRK1B0.60404961
91SGK10.60047165
92HIPK20.58296335
93KSR10.58231252
94ERBB20.58189563
95CDK150.57657326
96ERN10.56642684
97ARAF0.56407029
98PRKCZ0.55798451
99MARK10.55674545
100DDR20.55151148
101DYRK1A0.54872603
102BMPR20.54512904
103TAOK20.53473549
104MAPK70.53384310
105RAF10.52784354
106PRKAA10.52415444
107SYK0.52263497
108MAPKAPK30.50901190
109PKN20.50397444
110ADRBK20.49946420
111RPS6KA30.45910750
112PRKG10.45755647
113CSNK1D0.45464624
114PTK2B0.43976059
115PLK20.43794488
116MAP3K50.43439710
117MARK20.42645373
118PRKACG0.42116260
119MYLK0.41447274
120TGFBR10.41347316
121CAMK1D0.40320490
122SRC0.39872392
123PRKG20.39160420
124CSF1R0.38736266
125CDK140.38335714
126MAPK40.37950430
127TGFBR20.37099894
128INSRR0.37014401
129CDK30.36746434
130TXK0.34955532
131TRIB30.34683038
132UHMK10.34158756
133FYN0.33850459
134PRKCB0.33684043
135CDK180.33479582
136PHKG10.33438265
137PHKG20.33438265
138CAMK2D0.32910851
139CAMK2B0.32804198
140CDK11A0.32584502

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.43126801
2Nitrogen metabolism_Homo sapiens_hsa009103.58359199
3Nicotine addiction_Homo sapiens_hsa050333.32176845
4Olfactory transduction_Homo sapiens_hsa047402.69949915
5Synaptic vesicle cycle_Homo sapiens_hsa047212.69244458
6GABAergic synapse_Homo sapiens_hsa047272.65098802
7Circadian entrainment_Homo sapiens_hsa047132.56410824
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46404984
9Morphine addiction_Homo sapiens_hsa050322.34969880
10Glutamatergic synapse_Homo sapiens_hsa047242.32049751
11Histidine metabolism_Homo sapiens_hsa003402.12223180
12Long-term potentiation_Homo sapiens_hsa047202.07508490
13Salivary secretion_Homo sapiens_hsa049702.03506237
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.97257412
15Amphetamine addiction_Homo sapiens_hsa050311.91451344
16Fat digestion and absorption_Homo sapiens_hsa049751.90507057
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81501178
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.77707600
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74327366
20Phenylalanine metabolism_Homo sapiens_hsa003601.73914174
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70420685
22Insulin secretion_Homo sapiens_hsa049111.70185261
23Arginine biosynthesis_Homo sapiens_hsa002201.64840086
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.62957881
25Vitamin B6 metabolism_Homo sapiens_hsa007501.61208704
26Renin secretion_Homo sapiens_hsa049241.60808739
27Dopaminergic synapse_Homo sapiens_hsa047281.58477468
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56184472
29Cholinergic synapse_Homo sapiens_hsa047251.55176766
30Gastric acid secretion_Homo sapiens_hsa049711.54660484
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48841257
32Oxytocin signaling pathway_Homo sapiens_hsa049211.47037071
33Calcium signaling pathway_Homo sapiens_hsa040201.44322138
34Phototransduction_Homo sapiens_hsa047441.40468998
35Taste transduction_Homo sapiens_hsa047421.33318355
36Tyrosine metabolism_Homo sapiens_hsa003501.29158365
37Long-term depression_Homo sapiens_hsa047301.28202047
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27206258
39Circadian rhythm_Homo sapiens_hsa047101.25725026
40Serotonergic synapse_Homo sapiens_hsa047261.24813542
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24010808
42Arginine and proline metabolism_Homo sapiens_hsa003301.23934871
43GnRH signaling pathway_Homo sapiens_hsa049121.20479743
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19094412
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18064946
46Bile secretion_Homo sapiens_hsa049761.16063055
47Cocaine addiction_Homo sapiens_hsa050301.12516012
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09972452
49Retinol metabolism_Homo sapiens_hsa008301.09192381
50Vitamin digestion and absorption_Homo sapiens_hsa049771.08939657
51Steroid biosynthesis_Homo sapiens_hsa001001.08141034
52Butanoate metabolism_Homo sapiens_hsa006501.07281648
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06319607
54cAMP signaling pathway_Homo sapiens_hsa040241.05950747
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05076148
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03254831
57Staphylococcus aureus infection_Homo sapiens_hsa051500.98435670
58Prion diseases_Homo sapiens_hsa050200.95533597
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94028778
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91494044
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90536224
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.88578192
63Gap junction_Homo sapiens_hsa045400.86057489
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81995358
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81021188
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80926255
67Fatty acid degradation_Homo sapiens_hsa000710.75904392
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75055319
69Type II diabetes mellitus_Homo sapiens_hsa049300.74053531
70Caffeine metabolism_Homo sapiens_hsa002320.72879495
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.72279560
72Collecting duct acid secretion_Homo sapiens_hsa049660.72259846
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71422023
74Mineral absorption_Homo sapiens_hsa049780.67502743
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66648080
76Glucagon signaling pathway_Homo sapiens_hsa049220.66114484
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.64855472
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.63988557
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61926938
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61350875
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60212064
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59356194
83Estrogen signaling pathway_Homo sapiens_hsa049150.58624209
84Glycerolipid metabolism_Homo sapiens_hsa005610.58046102
85Other glycan degradation_Homo sapiens_hsa005110.57455457
86Propanoate metabolism_Homo sapiens_hsa006400.56713096
87Thyroid hormone synthesis_Homo sapiens_hsa049180.56399748
88Glioma_Homo sapiens_hsa052140.56098457
89African trypanosomiasis_Homo sapiens_hsa051430.55502594
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55347735
91Melanogenesis_Homo sapiens_hsa049160.55058304
92Platelet activation_Homo sapiens_hsa046110.54659677
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.53515689
94Insulin resistance_Homo sapiens_hsa049310.51219568
95Pancreatic secretion_Homo sapiens_hsa049720.50734196
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49794110
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49359885
98ABC transporters_Homo sapiens_hsa020100.49142852
99ErbB signaling pathway_Homo sapiens_hsa040120.49028746
100Fructose and mannose metabolism_Homo sapiens_hsa000510.48786749
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.48650301
102Fatty acid metabolism_Homo sapiens_hsa012120.48647658
103PPAR signaling pathway_Homo sapiens_hsa033200.48235444
104Peroxisome_Homo sapiens_hsa041460.46456406
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45831834
106Ovarian steroidogenesis_Homo sapiens_hsa049130.45821425
107Inositol phosphate metabolism_Homo sapiens_hsa005620.45819384
108Dilated cardiomyopathy_Homo sapiens_hsa054140.44567869
109Biosynthesis of amino acids_Homo sapiens_hsa012300.44030294
110Chemical carcinogenesis_Homo sapiens_hsa052040.42000962
111Tryptophan metabolism_Homo sapiens_hsa003800.41292270
112MAPK signaling pathway_Homo sapiens_hsa040100.41271315
113Lysine degradation_Homo sapiens_hsa003100.41171903
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40249805
115Insulin signaling pathway_Homo sapiens_hsa049100.40164960
116Cardiac muscle contraction_Homo sapiens_hsa042600.40157811
117Dorso-ventral axis formation_Homo sapiens_hsa043200.40126692
118Starch and sucrose metabolism_Homo sapiens_hsa005000.39454888
119N-Glycan biosynthesis_Homo sapiens_hsa005100.39209139
120beta-Alanine metabolism_Homo sapiens_hsa004100.39122957
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38508959
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.38225053
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.37837299
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37606200
125Renin-angiotensin system_Homo sapiens_hsa046140.37495475
126Carbon metabolism_Homo sapiens_hsa012000.37494638
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.37399887
128Galactose metabolism_Homo sapiens_hsa000520.36106093
129Non-small cell lung cancer_Homo sapiens_hsa052230.36076125
130Pyruvate metabolism_Homo sapiens_hsa006200.35626000
131Fatty acid biosynthesis_Homo sapiens_hsa000610.35180886
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34675299

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