HLA-H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.69026606
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.68931248
3antigen processing and presentation of endogenous antigen (GO:0019883)6.53702654
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.37387308
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.04806910
6negative regulation of cell killing (GO:0031342)6.04806910
7positive regulation of gamma-delta T cell activation (GO:0046645)5.21318548
8immunoglobulin mediated immune response (GO:0016064)5.10421359
9detection of bacterium (GO:0016045)4.74940192
10type I interferon signaling pathway (GO:0060337)4.74195466
11cellular response to type I interferon (GO:0071357)4.74195466
12response to type I interferon (GO:0034340)4.69888435
13regulation of B cell receptor signaling pathway (GO:0050855)4.67890646
14detection of other organism (GO:0098543)4.57638892
15interferon-gamma-mediated signaling pathway (GO:0060333)4.35532993
16cellular response to interleukin-15 (GO:0071350)4.17907369
17modulation by symbiont of host immune response (GO:0052553)4.17904144
18positive regulation by symbiont of host defense response (GO:0052509)4.17904144
19modulation by symbiont of host defense response (GO:0052031)4.17904144
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.17904144
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.17904144
22positive regulation by organism of defense response of other organism involved in symbiotic interact4.17904144
23B cell mediated immunity (GO:0019724)4.13145910
24response to interleukin-15 (GO:0070672)4.11489700
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.06143107
26regulation of gamma-delta T cell activation (GO:0046643)3.93532656
27negative thymic T cell selection (GO:0045060)3.86774918
28negative T cell selection (GO:0043383)3.84314015
29NIK/NF-kappaB signaling (GO:0038061)3.81854553
30negative regulation of interleukin-12 production (GO:0032695)3.77174216
31leukocyte aggregation (GO:0070486)3.76277376
32regulation of dendritic cell antigen processing and presentation (GO:0002604)3.73916503
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.71512929
34T cell migration (GO:0072678)3.70098874
35positive thymic T cell selection (GO:0045059)3.68181564
36* positive regulation of T cell mediated cytotoxicity (GO:0001916)3.65791005
37cytidine deamination (GO:0009972)3.65634936
38cytidine metabolic process (GO:0046087)3.65634936
39cytidine catabolic process (GO:0006216)3.65634936
40* regulation of T cell mediated cytotoxicity (GO:0001914)3.62595344
41regulation of T cell tolerance induction (GO:0002664)3.62180890
42B cell receptor signaling pathway (GO:0050853)3.61294882
43regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.60003668
44myeloid dendritic cell differentiation (GO:0043011)3.58037686
45regulation of alpha-beta T cell proliferation (GO:0046640)3.56476931
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.55327864
47T-helper 1 type immune response (GO:0042088)3.53434559
48regulation of natural killer cell mediated immunity (GO:0002715)3.52534169
49regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.52534169
50regulation of antigen processing and presentation (GO:0002577)3.47685813
51negative regulation of leukocyte mediated immunity (GO:0002704)3.44985096
52response to peptidoglycan (GO:0032494)3.43969471
53cellular response to interferon-gamma (GO:0071346)3.40923140
54respiratory burst (GO:0045730)3.39591983
55detection of external biotic stimulus (GO:0098581)3.39495871
56macrophage activation involved in immune response (GO:0002281)3.39248732
57regulation of gamma-delta T cell differentiation (GO:0045586)3.39144069
58myeloid dendritic cell activation (GO:0001773)3.37268920
59response to interferon-beta (GO:0035456)3.34256381
60thymic T cell selection (GO:0045061)3.29326804
61regulation of interferon-beta biosynthetic process (GO:0045357)3.29291124
62negative regulation of T cell mediated immunity (GO:0002710)3.27582546
63pyrimidine ribonucleoside catabolic process (GO:0046133)3.27234091
64regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.26753968
65positive regulation of antigen processing and presentation (GO:0002579)3.26738575
66neutrophil activation involved in immune response (GO:0002283)3.24899196
67antigen processing and presentation via MHC class Ib (GO:0002475)3.24574896
68defense response to protozoan (GO:0042832)3.24193113
69regulation of tolerance induction (GO:0002643)3.19440433
70T cell costimulation (GO:0031295)3.16786937
71response to interferon-gamma (GO:0034341)3.14996316
72lymphocyte costimulation (GO:0031294)3.14161101
73negative regulation of innate immune response (GO:0045824)3.14055253
74* regulation of leukocyte mediated cytotoxicity (GO:0001910)3.12455497
75negative regulation of viral genome replication (GO:0045071)3.11948490
76response to protozoan (GO:0001562)3.06232986
77positive T cell selection (GO:0043368)3.05604136
78positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.04892704
79* positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.04638481
80T cell selection (GO:0045058)3.02761574
81regulation of B cell differentiation (GO:0045577)3.01488024
82regulation of regulatory T cell differentiation (GO:0045589)3.00598196
83* regulation of cell killing (GO:0031341)2.98938315
84positive regulation of humoral immune response (GO:0002922)2.98237489
85positive regulation of alpha-beta T cell proliferation (GO:0046641)2.98002148
86tolerance induction (GO:0002507)2.97089625
87antigen receptor-mediated signaling pathway (GO:0050851)2.95618870
88detection of biotic stimulus (GO:0009595)2.95511956
89positive regulation of B cell mediated immunity (GO:0002714)2.94135885
90positive regulation of immunoglobulin mediated immune response (GO:0002891)2.94135885
91response to host immune response (GO:0052572)2.92602379
92response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.92602379
93* positive regulation of cell killing (GO:0031343)2.91738491
94positive regulation of interferon-alpha production (GO:0032727)2.88927417
95positive regulation of B cell differentiation (GO:0045579)2.88830651
96regulation of interleukin-2 biosynthetic process (GO:0045076)2.87321593
97regulation of interleukin-12 production (GO:0032655)2.86734926
98response to interferon-alpha (GO:0035455)2.86301736
99positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85905180
100germinal center formation (GO:0002467)2.84929411

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.46744195
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.92115649
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.22081337
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.95964687
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56228013
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.55025711
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.17797674
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.02992859
9STAT4_19710469_ChIP-ChIP_TH1__Mouse2.99060563
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.95626510
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.92345586
12MAF_26560356_Chip-Seq_TH1_Human2.62855869
13VDR_21846776_ChIP-Seq_THP-1_Human2.58943955
14MYB_26560356_Chip-Seq_TH2_Human2.48589549
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48028654
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.46507565
17MYC_22102868_ChIP-Seq_BL_Human2.45833222
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.37447636
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.34815297
20VDR_24763502_ChIP-Seq_THP-1_Human2.28160740
21RUNX_20019798_ChIP-Seq_JUKART_Human2.25882971
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25724519
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.24299542
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.23078390
25SPI1_23547873_ChIP-Seq_NB4_Human2.21138191
26UTX_26944678_Chip-Seq_JUKART_Human2.18011275
27MYB_26560356_Chip-Seq_TH1_Human2.15891365
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14954176
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.94295913
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93005589
31* MAF_26560356_Chip-Seq_TH2_Human1.89118813
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88333707
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77282571
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.73568054
35SPI1_23127762_ChIP-Seq_K562_Human1.72273573
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70277460
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.69117950
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68788450
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65185755
40GATA3_27048872_Chip-Seq_THYMUS_Human1.64161950
41LXR_22292898_ChIP-Seq_THP-1_Human1.61934676
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57508153
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52089986
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50737119
45TCF7_22412390_ChIP-Seq_EML_Mouse1.49989078
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47800615
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47236407
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43222652
49BCL6_27268052_Chip-Seq_Bcells_Human1.41347375
50SCL_19346495_ChIP-Seq_HPC-7_Human1.37020657
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.36857107
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36780210
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36235397
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33583171
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30672200
56BCOR_27268052_Chip-Seq_Bcells_Human1.30570387
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30565135
58KDM2B_26808549_Chip-Seq_DND41_Human1.28747791
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28427560
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.28334081
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26693095
62GATA3_26560356_Chip-Seq_TH2_Human1.26650350
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.25988111
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25709600
65GATA1_22025678_ChIP-Seq_K562_Human1.25118171
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22872265
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18951945
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18614999
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17863935
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16445339
71CIITA_25753668_ChIP-Seq_RAJI_Human1.15153844
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15080173
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.14091371
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12709535
75VDR_24787735_ChIP-Seq_THP-1_Human1.08629339
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08155005
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.06809339
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06342913
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03660423
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03657097
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99230046
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97186675
83P300_27268052_Chip-Seq_Bcells_Human0.95853068
84SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93680135
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93067445
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92550429
87CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92489850
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91730319
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91223683
90SA1_27219007_Chip-Seq_ERYTHROID_Human0.90971300
91TP63_17297297_ChIP-ChIP_HaCaT_Human0.89797139
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.88308185
93STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88053267
94P68_20966046_ChIP-Seq_HELA_Human0.88048103
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87832149
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86837854
97SPI1_20517297_ChIP-Seq_HL60_Human0.85320482
98SA1_27219007_Chip-Seq_Bcells_Human0.85316600
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85240793
100CTCF_26484167_Chip-Seq_Bcells_Mouse0.84921059

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.35902271
2MP0001835_abnormal_antigen_presentation4.29405483
3MP0003436_decreased_susceptibility_to3.89623434
4MP0000685_abnormal_immune_system3.77825340
5MP0003724_increased_susceptibility_to3.56620763
6MP0001790_abnormal_immune_system3.50228201
7MP0005387_immune_system_phenotype3.50228201
8MP0009785_altered_susceptibility_to3.36558475
9MP0001800_abnormal_humoral_immune3.31686053
10MP0005000_abnormal_immune_tolerance3.29547340
11MP0003303_peritoneal_inflammation3.13002843
12MP0005025_abnormal_response_to2.97555757
13MP0002723_abnormal_immune_serum2.84489596
14MP0002148_abnormal_hypersensitivity_rea2.79476301
15MP0003763_abnormal_thymus_physiology2.75805773
16MP0002452_abnormal_antigen_presenting2.72599922
17MP0002419_abnormal_innate_immunity2.66682196
18MP0002420_abnormal_adaptive_immunity2.63570575
19MP0001819_abnormal_immune_cell2.60551819
20MP0010155_abnormal_intestine_physiology2.51807779
21MP0006082_CNS_inflammation2.45456635
22MP0009333_abnormal_splenocyte_physiolog2.27918543
23MP0003300_gastrointestinal_ulcer2.06847790
24MP0003183_abnormal_peptide_metabolism2.03247089
25MP0001845_abnormal_inflammatory_respons2.02500819
26MP0000716_abnormal_immune_system2.01384494
27MP0002398_abnormal_bone_marrow2.00748594
28MP0001533_abnormal_skeleton_physiology1.95519463
29MP0002138_abnormal_hepatobiliary_system1.94798579
30MP0003866_abnormal_defecation1.90928576
31MP0002405_respiratory_system_inflammati1.90274434
32MP0004947_skin_inflammation1.81343126
33MP0001873_stomach_inflammation1.75636982
34MP0002166_altered_tumor_susceptibility1.74416150
35MP0005464_abnormal_platelet_physiology1.65487181
36MP0000689_abnormal_spleen_morphology1.63282070
37MP0005310_abnormal_salivary_gland1.60894071
38MP0002429_abnormal_blood_cell1.60304300
39MP0002722_abnormal_immune_system1.59824542
40MP0008469_abnormal_protein_level1.59162752
41MP0004510_myositis1.51806717
42MP0003191_abnormal_cellular_cholesterol1.46080432
43MP0009764_decreased_sensitivity_to1.41627508
44MP0000703_abnormal_thymus_morphology1.38949074
45MP0009840_abnormal_foam_cell1.37589527
46MP0000465_gastrointestinal_hemorrhage1.34220730
47MP0002006_tumorigenesis1.27889949
48MP0005058_abnormal_lysosome_morphology1.20386834
49MP0003806_abnormal_nucleotide_metabolis1.19426164
50MP0005166_decreased_susceptibility_to1.19418343
51MP0001853_heart_inflammation1.16163117
52MP0000858_altered_metastatic_potential1.15140260
53MP0008260_abnormal_autophagy1.14244921
54MP0005451_abnormal_body_composition1.13807672
55MP0002998_abnormal_bone_remodeling1.10578731
56MP0000490_abnormal_crypts_of1.07342308
57MP0003075_altered_response_to1.06926786
58MP0002139_abnormal_hepatobiliary_system1.04850490
59MP0002933_joint_inflammation1.04103408
60MP0003045_fibrosis1.02945648
61MP0009763_increased_sensitivity_to0.97692432
62MP0000343_altered_response_to0.97227766
63MP0003448_altered_tumor_morphology0.96863103
64MP0003172_abnormal_lysosome_physiology0.95885947
65MP0002254_reproductive_system_inflammat0.95662503
66MP0001663_abnormal_digestive_system0.94503403
67MP0002132_abnormal_respiratory_system0.93961002
68MP0009278_abnormal_bone_marrow0.92213122
69MP0002277_abnormal_respiratory_mucosa0.90526260
70MP0005360_urolithiasis0.87584852
71MP0000604_amyloidosis0.84460388
72MP0005390_skeleton_phenotype0.82382465
73MP0002396_abnormal_hematopoietic_system0.80411592
74MP0001348_abnormal_lacrimal_gland0.76805007
75MP0005645_abnormal_hypothalamus_physiol0.73535576
76MP0000249_abnormal_blood_vessel0.69345954
77MP0001851_eye_inflammation0.68771832
78MP0002136_abnormal_kidney_physiology0.67735074
79MP0009765_abnormal_xenobiotic_induced0.66698988
80MP0004381_abnormal_hair_follicle0.66214575
81MP0004883_abnormal_blood_vessel0.65438151
82MP0003828_pulmonary_edema0.64852239
83MP0003795_abnormal_bone_structure0.64428480
84MP0002693_abnormal_pancreas_physiology0.63812964
85MP0009643_abnormal_urine_homeostasis0.63444633
86MP0001545_abnormal_hematopoietic_system0.62301176
87MP0005397_hematopoietic_system_phenotyp0.62301176
88MP0000609_abnormal_liver_physiology0.61124168
89MP0002019_abnormal_tumor_incidence0.58931238
90MP0005164_abnormal_response_to0.56114190
91MP0005319_abnormal_enzyme/_coenzyme0.56002243
92MP0005381_digestive/alimentary_phenotyp0.54773600
93MP0008874_decreased_physiological_sensi0.52519812
94MP0005584_abnormal_enzyme/coenzyme_acti0.52458904
95MP0005165_increased_susceptibility_to0.51390734
96MP0008004_abnormal_stomach_pH0.50292665
97MP0005535_abnormal_body_temperature0.45497237
98MP0009642_abnormal_blood_homeostasis0.44103268
99MP0005075_abnormal_melanosome_morpholog0.43501915
100MP0001765_abnormal_ion_homeostasis0.42803994

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.96553318
2Abnormality of macrophages (HP:0004311)4.91517516
3Myositis (HP:0100614)4.91472837
4Elevated erythrocyte sedimentation rate (HP:0003565)4.85208312
5Orchitis (HP:0100796)4.71349928
6Recurrent bacterial skin infections (HP:0005406)4.70752682
7Recurrent abscess formation (HP:0002722)4.62582628
8Retrobulbar optic neuritis (HP:0100654)4.59532228
9Optic neuritis (HP:0100653)4.59532228
10Meningitis (HP:0001287)4.53808977
11Vasculitis (HP:0002633)4.36563344
12Mediastinal lymphadenopathy (HP:0100721)4.30078617
13Gastrointestinal stroma tumor (HP:0100723)4.28399637
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.16638531
15Recurrent bronchitis (HP:0002837)3.93433113
16Recurrent fungal infections (HP:0002841)3.87649383
17Stomatitis (HP:0010280)3.81530800
18Obstructive lung disease (HP:0006536)3.79267206
19Chronic obstructive pulmonary disease (HP:0006510)3.79267206
20Agammaglobulinemia (HP:0004432)3.75247699
21Gastrointestinal infarctions (HP:0005244)3.74871341
22Recurrent gram-negative bacterial infections (HP:0005420)3.74845085
23Encephalitis (HP:0002383)3.72517136
24Increased IgM level (HP:0003496)3.58112184
25Urticaria (HP:0001025)3.57317311
26Pulmonary infiltrates (HP:0002113)3.53638518
27Lymphopenia (HP:0001888)3.49575449
28IgM deficiency (HP:0002850)3.44793735
29Recurrent cutaneous fungal infections (HP:0011370)3.42692185
30Chronic mucocutaneous candidiasis (HP:0002728)3.42692185
31Recurrent skin infections (HP:0001581)3.40642321
32Abnormality of cells of the lymphoid lineage (HP:0012140)3.40221143
33Recurrent sinusitis (HP:0011108)3.39408794
34Cellulitis (HP:0100658)3.35511074
35Chronic diarrhea (HP:0002028)3.34672903
36Keratoconjunctivitis sicca (HP:0001097)3.30480898
37Abnormality of T cells (HP:0002843)3.28872934
38IgG deficiency (HP:0004315)3.28868843
39Recurrent viral infections (HP:0004429)3.25636980
40Increased IgE level (HP:0003212)3.24019807
41Abnormality of T cell number (HP:0011839)3.23408967
42Abnormality of T cell physiology (HP:0011840)3.18864959
43T lymphocytopenia (HP:0005403)3.18619088
44Keratoconjunctivitis (HP:0001096)3.10448031
45Petechiae (HP:0000967)3.02380202
46Hemoptysis (HP:0002105)2.96822835
47Chest pain (HP:0100749)2.95991887
48Panhypogammaglobulinemia (HP:0003139)2.93515920
49Emphysema (HP:0002097)2.89779780
50IgA deficiency (HP:0002720)2.87569683
51Premature loss of primary teeth (HP:0006323)2.79728005
52Inflammation of the large intestine (HP:0002037)2.79032496
53Hypergammaglobulinemia (HP:0010702)2.72916730
54Gingivitis (HP:0000230)2.72239206
55Abnormality of the pleura (HP:0002103)2.72091837
56Gastrointestinal inflammation (HP:0004386)2.70913939
57Chronic otitis media (HP:0000389)2.70223454
58Colitis (HP:0002583)2.67984068
59Osteomyelitis (HP:0002754)2.66276067
60Skin rash (HP:0000988)2.65657653
61Pustule (HP:0200039)2.65398475
62Spontaneous hematomas (HP:0007420)2.63742544
63Autoimmune hemolytic anemia (HP:0001890)2.60372266
64Restrictive lung disease (HP:0002091)2.59442163
65Recurrent pneumonia (HP:0006532)2.59398053
66Leukocytosis (HP:0001974)2.53124253
67Gangrene (HP:0100758)2.50664897
68Recurrent lower respiratory tract infections (HP:0002783)2.45013080
69Granulocytopenia (HP:0001913)2.44356275
70Pulmonary embolism (HP:0002204)2.39580704
71Arterial thrombosis (HP:0004420)2.38389791
72Anorexia (HP:0002039)2.35371775
73Sepsis (HP:0100806)2.35042421
74Systemic lupus erythematosus (HP:0002725)2.34665275
75Abnormality of B cell number (HP:0010975)2.34190461
76Purpura (HP:0000979)2.32991156
77Joint swelling (HP:0001386)2.31495999
78Hypochromic anemia (HP:0001931)2.29890557
79Arthralgia (HP:0002829)2.29861124
80Abnormality of the prostate (HP:0008775)2.28808611
81Autoimmune thrombocytopenia (HP:0001973)2.27840655
82Bronchitis (HP:0012387)2.21154269
83Glomerulopathy (HP:0100820)2.19398162
84Hypertensive crisis (HP:0100735)2.18060466
85Eosinophilia (HP:0001880)2.17688791
86Malnutrition (HP:0004395)2.17446117
87Nasal polyposis (HP:0100582)2.17375171
88Skin ulcer (HP:0200042)2.15535490
89Abnormality of the pericardium (HP:0001697)2.14244609
90Hepatosplenomegaly (HP:0001433)2.13257126
91Abnormality of liposaccharide metabolism (HP:0010968)2.11727556
92Abnormality of glycosphingolipid metabolism (HP:0004343)2.11727556
93Abnormality of glycolipid metabolism (HP:0010969)2.11727556
94Papilloma (HP:0012740)2.11658930
95Verrucae (HP:0200043)2.11658930
96B lymphocytopenia (HP:0010976)2.09411778
97Epistaxis (HP:0000421)2.08733736
98Acute hepatic failure (HP:0006554)2.05998189
99Abnormality of eosinophils (HP:0001879)2.02891595
100Abnormality of the nasal mucosa (HP:0000433)2.01767646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.74270793
2RIPK44.21768401
3IRAK43.40236239
4ERN13.19837851
5TXK2.67066123
6TYK22.51970873
7BLK2.50815137
8TLK12.41196784
9TBK12.35894902
10MAP3K142.35757874
11IKBKE2.18941686
12CSK2.16998446
13PRPF4B2.03884125
14GRK61.94326972
15SYK1.94208889
16JAK31.90289414
17FES1.87858126
18TESK21.83173372
19BTK1.80577908
20SMG11.70964519
21TNK21.68553033
22MAP3K131.65338215
23ZAP701.65078492
24EPHB11.64619850
25MAP2K31.61743649
26IKBKB1.61373130
27JAK11.61004453
28KIT1.58223731
29MAP3K111.55803266
30LYN1.45605081
31CSF1R1.45492189
32FGFR41.44222383
33SIK31.43622577
34VRK11.40573834
35ITK1.39930266
36HCK1.31164570
37LCK1.27415905
38KDR1.24288619
39MAP3K31.22343899
40BCKDK1.20058011
41TAOK11.17467188
42TAOK21.14840010
43EPHA31.12641264
44MATK1.07547784
45IRAK31.06935514
46TAOK31.05713121
47JAK21.04251278
48SIK21.03578048
49DAPK31.01630185
50PRKCQ0.98945449
51FGR0.94853881
52MAP3K10.94797785
53ZAK0.93187282
54BMPR20.92096864
55MARK30.85456306
56TEC0.83861803
57SIK10.78195654
58PDK10.73059378
59CDC42BPA0.72473887
60RPS6KA50.70331045
61IRAK10.69949882
62HIPK20.68714323
63PIM10.67621694
64CDK190.67568063
65FGFR30.60435437
66CHUK0.60014047
67STK100.58692328
68MAP2K60.56575432
69PTK60.54963755
70ARAF0.53175379
71FYN0.53074625
72MAPK110.52346256
73PDPK10.50775471
74MAPK70.50235081
75PRKD20.49594604
76PASK0.48174101
77TRIB30.44997117
78PRKCD0.43756391
79MAPK120.43103308
80MAPKAPK20.42351687
81GRK70.41689690
82TESK10.41095862
83KSR20.40841866
84MAP2K20.40506911
85PRKG20.40389634
86NEK90.36634336
87MAP3K80.34452736
88ALK0.33234063
89MAP3K50.32498071
90CDK40.30067063
91NLK0.27988763
92RPS6KL10.27843538
93RPS6KC10.27843538
94PRKCH0.26922672
95MAPKAPK30.24805918
96PIM20.24437087
97INSR0.23327480
98ABL10.23055218
99RPS6KA60.21951907
100LRRK20.21594077

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.37263800
2Autoimmune thyroid disease_Homo sapiens_hsa053204.04577968
3Graft-versus-host disease_Homo sapiens_hsa053324.00081675
4Primary immunodeficiency_Homo sapiens_hsa053403.62949865
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.48053896
6Type I diabetes mellitus_Homo sapiens_hsa049403.31744927
7Asthma_Homo sapiens_hsa053103.30767264
8Systemic lupus erythematosus_Homo sapiens_hsa053223.01159377
9Antigen processing and presentation_Homo sapiens_hsa046122.87911565
10Leishmaniasis_Homo sapiens_hsa051402.84166614
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.75787546
12Staphylococcus aureus infection_Homo sapiens_hsa051502.73060137
13Viral myocarditis_Homo sapiens_hsa054162.48893807
14Osteoclast differentiation_Homo sapiens_hsa043802.02342138
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.96571272
16B cell receptor signaling pathway_Homo sapiens_hsa046621.89913014
17Hematopoietic cell lineage_Homo sapiens_hsa046401.85311532
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85252706
19Rheumatoid arthritis_Homo sapiens_hsa053231.75929641
20Measles_Homo sapiens_hsa051621.68758472
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67275909
22Herpes simplex infection_Homo sapiens_hsa051681.66414773
23Tuberculosis_Homo sapiens_hsa051521.64329453
24Influenza A_Homo sapiens_hsa051641.58123623
25Toxoplasmosis_Homo sapiens_hsa051451.48305117
26T cell receptor signaling pathway_Homo sapiens_hsa046601.44468339
27Alcoholism_Homo sapiens_hsa050341.32649320
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31775047
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29334175
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22358642
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21604628
32Malaria_Homo sapiens_hsa051441.20749097
33Chemokine signaling pathway_Homo sapiens_hsa040621.16217515
34Phagosome_Homo sapiens_hsa041451.15671244
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15037014
36Viral carcinogenesis_Homo sapiens_hsa052031.12725604
37TNF signaling pathway_Homo sapiens_hsa046681.10251777
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09600997
39Other glycan degradation_Homo sapiens_hsa005111.06608666
40Jak-STAT signaling pathway_Homo sapiens_hsa046300.98322485
41Epstein-Barr virus infection_Homo sapiens_hsa051690.94600317
42Legionellosis_Homo sapiens_hsa051340.91428206
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89300167
44African trypanosomiasis_Homo sapiens_hsa051430.88925087
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85609315
46Hepatitis C_Homo sapiens_hsa051600.84831088
47Pertussis_Homo sapiens_hsa051330.83760047
48Apoptosis_Homo sapiens_hsa042100.83009111
49Shigellosis_Homo sapiens_hsa051310.80238385
50Acute myeloid leukemia_Homo sapiens_hsa052210.79864279
51Salmonella infection_Homo sapiens_hsa051320.77559896
52Hepatitis B_Homo sapiens_hsa051610.76502790
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76084235
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70366175
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.66562911
56HTLV-I infection_Homo sapiens_hsa051660.66540223
57Fructose and mannose metabolism_Homo sapiens_hsa000510.57526248
58Lysosome_Homo sapiens_hsa041420.53882195
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.45445979
60Renin-angiotensin system_Homo sapiens_hsa046140.43771999
61Platelet activation_Homo sapiens_hsa046110.41564360
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37035388
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.32816014
64Endocytosis_Homo sapiens_hsa041440.32375612
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31037194
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28245412
67Galactose metabolism_Homo sapiens_hsa000520.26473073
68Prolactin signaling pathway_Homo sapiens_hsa049170.25609934
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23725359
70VEGF signaling pathway_Homo sapiens_hsa043700.22840596
71Pancreatic cancer_Homo sapiens_hsa052120.22318196
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22247397
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22094629
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20817989
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.20262588
76Arachidonic acid metabolism_Homo sapiens_hsa005900.20125394
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19807052
78Sulfur metabolism_Homo sapiens_hsa009200.17861449
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.17623441
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.16524800
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15580217
82Non-small cell lung cancer_Homo sapiens_hsa052230.14842708
83Pentose phosphate pathway_Homo sapiens_hsa000300.14703927
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.13754456
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.13292752
86Prion diseases_Homo sapiens_hsa050200.12365575
87Insulin resistance_Homo sapiens_hsa049310.12269560
88Fat digestion and absorption_Homo sapiens_hsa049750.11958587
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.11388957
90HIF-1 signaling pathway_Homo sapiens_hsa040660.11049246
91Proteasome_Homo sapiens_hsa030500.10983641
92Vitamin digestion and absorption_Homo sapiens_hsa049770.10025550
93Amoebiasis_Homo sapiens_hsa051460.08214324
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05938666
95Chronic myeloid leukemia_Homo sapiens_hsa052200.04596576
96Bladder cancer_Homo sapiens_hsa052190.03814082
97MAPK signaling pathway_Homo sapiens_hsa040100.03751826
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.02492110
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.02461095
100Mineral absorption_Homo sapiens_hsa049780.01062135

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