HLA-DQA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)6.80520365
2* interferon-gamma-mediated signaling pathway (GO:0060333)5.87638782
3B cell mediated immunity (GO:0019724)5.34542673
4regulation of B cell receptor signaling pathway (GO:0050855)5.29277303
5regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.97098935
6* T cell costimulation (GO:0031295)4.95084719
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.91189798
8* lymphocyte costimulation (GO:0031294)4.88220650
9detection of bacterium (GO:0016045)4.78980718
10* cellular response to interferon-gamma (GO:0071346)4.77609399
11positive regulation of mast cell degranulation (GO:0043306)4.65380226
12positive regulation of mast cell activation involved in immune response (GO:0033008)4.65380226
13positive regulation of mast cell activation (GO:0033005)4.59847313
14detection of other organism (GO:0098543)4.51931359
15regulation of alpha-beta T cell proliferation (GO:0046640)4.47306858
16antigen processing and presentation of endogenous antigen (GO:0019883)4.44467677
17mature B cell differentiation involved in immune response (GO:0002313)4.35897082
18T-helper 1 type immune response (GO:0042088)4.33063858
19regulation of antigen processing and presentation (GO:0002577)4.31642965
20neutrophil activation involved in immune response (GO:0002283)4.20508904
21* response to interferon-gamma (GO:0034341)4.18256277
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.14552673
23positive regulation by organism of defense response of other organism involved in symbiotic interact4.14552673
24modulation by symbiont of host immune response (GO:0052553)4.14552673
25positive regulation by symbiont of host defense response (GO:0052509)4.14552673
26modulation by symbiont of host defense response (GO:0052031)4.14552673
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.14552673
28positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.09633482
29regulation of hypersensitivity (GO:0002883)4.04113547
30regulation of dendritic cell antigen processing and presentation (GO:0002604)4.03240393
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98766681
32positive regulation of gamma-delta T cell activation (GO:0046645)3.97488632
33mature B cell differentiation (GO:0002335)3.97315779
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90008168
35positive regulation of antigen processing and presentation (GO:0002579)3.86210161
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.84443850
37detection of external biotic stimulus (GO:0098581)3.81069151
38B cell receptor signaling pathway (GO:0050853)3.73730362
39negative regulation of B cell proliferation (GO:0030889)3.72847647
40positive regulation of type 2 immune response (GO:0002830)3.70338047
41regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.68307353
42regulation of mast cell degranulation (GO:0043304)3.66711812
43macrophage activation involved in immune response (GO:0002281)3.64114364
44defense response to protozoan (GO:0042832)3.63805658
45antigen processing and presentation via MHC class Ib (GO:0002475)3.60843225
46regulation of mast cell activation (GO:0033003)3.53256034
47positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.52979852
48negative regulation of alpha-beta T cell activation (GO:0046636)3.50840341
49microglial cell activation (GO:0001774)3.49900028
50response to peptidoglycan (GO:0032494)3.49847932
51positive regulation of leukocyte degranulation (GO:0043302)3.42755094
52cellular response to type I interferon (GO:0071357)3.41425061
53type I interferon signaling pathway (GO:0060337)3.41425061
54regulation of B cell proliferation (GO:0030888)3.39539441
55regulation of T cell tolerance induction (GO:0002664)3.38872051
56positive regulation of interferon-gamma production (GO:0032729)3.38081597
57response to type I interferon (GO:0034340)3.38035519
58positive thymic T cell selection (GO:0045059)3.35465763
59* antigen receptor-mediated signaling pathway (GO:0050851)3.35167265
60positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.35035262
61myeloid dendritic cell activation (GO:0001773)3.34650568
62negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.33417194
63negative regulation of cell killing (GO:0031342)3.33417194
64regulation of mast cell activation involved in immune response (GO:0033006)3.31917571
65regulation of T-helper 1 cell differentiation (GO:0045625)3.28888574
66myeloid dendritic cell differentiation (GO:0043011)3.27715688
67response to protozoan (GO:0001562)3.26076150
68detection of biotic stimulus (GO:0009595)3.24003974
69regulation of interferon-beta biosynthetic process (GO:0045357)3.20533310
70mast cell activation (GO:0045576)3.18501100
71positive regulation of B cell proliferation (GO:0030890)3.15172815
72production of molecular mediator of immune response (GO:0002440)3.15092084
73Arp2/3 complex-mediated actin nucleation (GO:0034314)3.12735419
74* T cell receptor signaling pathway (GO:0050852)3.12555072
75adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.11411552
76regulation of inflammatory response to antigenic stimulus (GO:0002861)3.06185679
77regulation of tolerance induction (GO:0002643)3.05122950
78myeloid cell activation involved in immune response (GO:0002275)3.04494169
79detection of molecule of bacterial origin (GO:0032490)2.99489606
80positive regulation of alpha-beta T cell proliferation (GO:0046641)2.94009295
81positive regulation of immunoglobulin mediated immune response (GO:0002891)2.93945684
82positive regulation of B cell mediated immunity (GO:0002714)2.93945684
83* positive regulation of T cell activation (GO:0050870)2.92907396
84positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.90493279
85positive regulation of T cell proliferation (GO:0042102)2.89928501
86positive regulation of lymphocyte proliferation (GO:0050671)2.89543728
87positive regulation of mononuclear cell proliferation (GO:0032946)2.88980224
88positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.88979028
89positive regulation of leukocyte proliferation (GO:0070665)2.88675040
90positive regulation of B cell differentiation (GO:0045579)2.88405867
91* immune response-activating cell surface receptor signaling pathway (GO:0002429)2.87406953
92positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.86272369
93regulation of gamma-delta T cell activation (GO:0046643)2.82504081
94response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.82435397
95response to host immune response (GO:0052572)2.82435397
96negative regulation of interleukin-12 production (GO:0032695)2.82425042
97positive regulation of interleukin-17 production (GO:0032740)2.81628874
98regulation of interleukin-2 biosynthetic process (GO:0045076)2.81237917
99regulation of interferon-gamma production (GO:0032649)2.80244272
100negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.79958785

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.67692372
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.67823463
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.50281910
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.59130108
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.15386148
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.00718857
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.80185657
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.50446842
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.18985660
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.07824265
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.91073391
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.88312470
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75442648
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64994541
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59655658
16* SPI1_23547873_ChIP-Seq_NB4_Human2.54007600
17MYB_26560356_Chip-Seq_TH2_Human2.43294372
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.42334658
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.32738473
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04026449
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03948441
22RUNX_20019798_ChIP-Seq_JUKART_Human2.01738748
23SCL_19346495_ChIP-Seq_HPC-7_Human1.95701165
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.94523432
25MYC_22102868_ChIP-Seq_BL_Human1.93710491
26CIITA_25753668_ChIP-Seq_RAJI_Human1.89908209
27MYB_26560356_Chip-Seq_TH1_Human1.86228210
28VDR_24763502_ChIP-Seq_THP-1_Human1.76252579
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.75919449
30SPI1_23127762_ChIP-Seq_K562_Human1.75907323
31MAF_26560356_Chip-Seq_TH1_Human1.74508494
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72608122
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.69907378
34VDR_24787735_ChIP-Seq_THP-1_Human1.67621957
35GATA3_27048872_Chip-Seq_THYMUS_Human1.60865460
36GATA3_26560356_Chip-Seq_TH2_Human1.59522621
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52446191
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.51898394
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50481505
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49759930
41NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.44000727
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41445523
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39492732
44VDR_21846776_ChIP-Seq_THP-1_Human1.38762130
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36466152
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.31525617
47UTX_26944678_Chip-Seq_JUKART_Human1.31464244
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22841981
49GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21038051
50VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20674811
51CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20038934
52SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18331800
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18168255
54PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16067289
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14930703
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13969641
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13559632
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12962852
59EGR1_19032775_ChIP-ChIP_M12_Human1.11055008
60PU_27001747_Chip-Seq_BMDM_Mouse1.10763025
61MAF_26560356_Chip-Seq_TH2_Human1.10145341
62PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06505838
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04223982
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00926178
65BCL6_27268052_Chip-Seq_Bcells_Human1.00782627
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00451548
67STAT1_20625510_ChIP-Seq_HELA_Human1.00346829
68SMAD_19615063_ChIP-ChIP_OVARY_Human0.98927189
69EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94506618
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94395679
71GATA1_22025678_ChIP-Seq_K562_Human0.92544648
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92178266
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92140069
74CDX2_20551321_ChIP-Seq_CACO-2_Human0.92103180
75GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88953400
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87646515
77EGR1_19374776_ChIP-ChIP_THP-1_Human0.86160883
78P300_27268052_Chip-Seq_Bcells_Human0.84342566
79SPI1_20517297_ChIP-Seq_HL60_Human0.81866838
80SMRT_27268052_Chip-Seq_Bcells_Human0.81677892
81TCF7_22412390_ChIP-Seq_EML_Mouse0.80535099
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80348307
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79595679
84BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76737229
85LXR_22292898_ChIP-Seq_THP-1_Human0.75737910
86BCOR_27268052_Chip-Seq_Bcells_Human0.75447897
87CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75307592
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.75205979
89TAF2_19829295_ChIP-Seq_ESCs_Human0.73192507
90SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72643083
91KDM2B_26808549_Chip-Seq_SUP-B15_Human0.72364458
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70906480
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.70501894
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.70437028
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70075678
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.69112402
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.68878201
98CEBPB_22108803_ChIP-Seq_LS180_Human0.68714140
99TFEB_21752829_ChIP-Seq_HELA_Human0.67901880
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.67527391

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.04797582
2MP0005671_abnormal_response_to4.71460045
3MP0001800_abnormal_humoral_immune3.58360480
4MP0000685_abnormal_immune_system3.40806553
5MP0003303_peritoneal_inflammation3.40744406
6MP0003724_increased_susceptibility_to3.23404748
7MP0005387_immune_system_phenotype3.23269017
8MP0001790_abnormal_immune_system3.23269017
9MP0005000_abnormal_immune_tolerance3.21749141
10MP0009785_altered_susceptibility_to3.13150971
11MP0002452_abnormal_antigen_presenting3.06581908
12MP0002148_abnormal_hypersensitivity_rea2.83021382
13MP0002723_abnormal_immune_serum2.81098079
14MP0003436_decreased_susceptibility_to2.80357280
15MP0005025_abnormal_response_to2.65036536
16MP0002419_abnormal_innate_immunity2.56772614
17MP0001819_abnormal_immune_cell2.55992264
18MP0002420_abnormal_adaptive_immunity2.50135542
19MP0010155_abnormal_intestine_physiology2.48831312
20MP0002166_altered_tumor_susceptibility2.41857191
21MP0006082_CNS_inflammation2.05713270
22MP0005451_abnormal_body_composition1.93268333
23MP0000716_abnormal_immune_system1.89492920
24MP0003763_abnormal_thymus_physiology1.86978958
25MP0001845_abnormal_inflammatory_respons1.86492233
26MP0002138_abnormal_hepatobiliary_system1.85338976
27MP0009764_decreased_sensitivity_to1.84360935
28MP0002398_abnormal_bone_marrow1.82157462
29MP0009333_abnormal_splenocyte_physiolog1.77441165
30MP0003806_abnormal_nucleotide_metabolis1.74972076
31MP0003183_abnormal_peptide_metabolism1.74952956
32MP0001873_stomach_inflammation1.72560258
33MP0002006_tumorigenesis1.72509326
34MP0003075_altered_response_to1.69026990
35MP0005166_decreased_susceptibility_to1.68531689
36MP0003300_gastrointestinal_ulcer1.66389877
37MP0001853_heart_inflammation1.65418747
38MP0002139_abnormal_hepatobiliary_system1.62275654
39MP0003866_abnormal_defecation1.60447101
40MP0004947_skin_inflammation1.58129471
41MP0008469_abnormal_protein_level1.49905231
42MP0009379_abnormal_foot_pigmentation1.49164627
43MP0002405_respiratory_system_inflammati1.49100066
44MP0005464_abnormal_platelet_physiology1.47040166
45MP0002429_abnormal_blood_cell1.46181373
46MP0001533_abnormal_skeleton_physiology1.41096522
47MP0000689_abnormal_spleen_morphology1.33919970
48MP0000858_altered_metastatic_potential1.32836959
49MP0000465_gastrointestinal_hemorrhage1.27968010
50MP0005058_abnormal_lysosome_morphology1.22025904
51MP0003172_abnormal_lysosome_physiology1.20952947
52MP0002722_abnormal_immune_system1.17276464
53MP0002998_abnormal_bone_remodeling1.11632442
54MP0003045_fibrosis1.10575532
55MP0005310_abnormal_salivary_gland1.05712294
56MP0002396_abnormal_hematopoietic_system1.05240811
57MP0005360_urolithiasis1.00943195
58MP0008004_abnormal_stomach_pH1.00633045
59MP0001663_abnormal_digestive_system0.99371704
60MP0000343_altered_response_to0.97000546
61MP0003191_abnormal_cellular_cholesterol0.84665895
62MP0009763_increased_sensitivity_to0.84335068
63MP0000516_abnormal_urinary_system0.84195947
64MP0005367_renal/urinary_system_phenotyp0.84195947
65MP0003448_altered_tumor_morphology0.83210319
66MP0005075_abnormal_melanosome_morpholog0.81938953
67MP0002796_impaired_skin_barrier0.80716858
68MP0004510_myositis0.79019367
69MP0005165_increased_susceptibility_to0.78242652
70MP0005397_hematopoietic_system_phenotyp0.77404452
71MP0001545_abnormal_hematopoietic_system0.77404452
72MP0000249_abnormal_blood_vessel0.77250167
73MP0009643_abnormal_urine_homeostasis0.75467565
74MP0002136_abnormal_kidney_physiology0.74959690
75MP0000490_abnormal_crypts_of0.73958647
76MP0000703_abnormal_thymus_morphology0.73669384
77MP0005670_abnormal_white_adipose0.70621068
78MP0004381_abnormal_hair_follicle0.69417357
79MP0005584_abnormal_enzyme/coenzyme_acti0.65105836
80MP0005275_abnormal_skin_tensile0.64468049
81MP0005645_abnormal_hypothalamus_physiol0.63862798
82MP0005535_abnormal_body_temperature0.61944679
83MP0008260_abnormal_autophagy0.61418675
84MP0005085_abnormal_gallbladder_physiolo0.61063290
85MP0001851_eye_inflammation0.59008835
86MP0005381_digestive/alimentary_phenotyp0.57948309
87MP0000604_amyloidosis0.56298465
88MP0002933_joint_inflammation0.55958107
89MP0003795_abnormal_bone_structure0.55325394
90MP0006036_abnormal_mitochondrial_physio0.54753699
91MP0009765_abnormal_xenobiotic_induced0.54458081
92MP0003091_abnormal_cell_migration0.53586873
93MP0003252_abnormal_bile_duct0.52802464
94MP0004264_abnormal_extraembryonic_tissu0.52159779
95MP0008874_decreased_physiological_sensi0.49070333
96MP0000371_diluted_coat_color0.48118293
97MP0001666_abnormal_nutrient_absorption0.47851649
98MP0001765_abnormal_ion_homeostasis0.47444924
99MP0000920_abnormal_myelination0.47327055
100MP0005390_skeleton_phenotype0.47305812

Predicted human phenotypes

RankGene SetZ-score
1Obstructive lung disease (HP:0006536)5.22027853
2Chronic obstructive pulmonary disease (HP:0006510)5.22027853
3Vasculitis (HP:0002633)5.05296131
4Meningitis (HP:0001287)4.79486195
5Hemoptysis (HP:0002105)4.55849899
6Eczematoid dermatitis (HP:0000976)4.33688626
7Recurrent bacterial skin infections (HP:0005406)4.23929027
8Gastrointestinal stroma tumor (HP:0100723)4.14619563
9Abnormality of the prostate (HP:0008775)4.04179281
10Agammaglobulinemia (HP:0004432)4.03339341
11Pulmonary infiltrates (HP:0002113)4.01533466
12Recurrent abscess formation (HP:0002722)3.99609312
13Restrictive lung disease (HP:0002091)3.88044523
14Mediastinal lymphadenopathy (HP:0100721)3.78474193
15Recurrent sinusitis (HP:0011108)3.77815069
16Abnormality of the pleura (HP:0002103)3.70264749
17Systemic lupus erythematosus (HP:0002725)3.68440699
18Gastrointestinal infarctions (HP:0005244)3.65811812
19Urticaria (HP:0001025)3.54560554
20Chronic mucocutaneous candidiasis (HP:0002728)3.49885432
21Recurrent cutaneous fungal infections (HP:0011370)3.49885432
22Emphysema (HP:0002097)3.43526376
23Recurrent fungal infections (HP:0002841)3.40921927
24Abnormality of macrophages (HP:0004311)3.40889640
25Chest pain (HP:0100749)3.39496204
26Gangrene (HP:0100758)3.34235118
27Recurrent bronchitis (HP:0002837)3.32944916
28Recurrent skin infections (HP:0001581)3.30765938
29Skin rash (HP:0000988)3.25517537
30Elevated erythrocyte sedimentation rate (HP:0003565)3.20326798
31Increased IgE level (HP:0003212)3.20171400
32Chronic diarrhea (HP:0002028)3.05205338
33Panhypogammaglobulinemia (HP:0003139)3.02586572
34Acrocyanosis (HP:0001063)3.01010732
35Increased IgM level (HP:0003496)2.99909529
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.98031770
37Ureteral stenosis (HP:0000071)2.92743795
38Myositis (HP:0100614)2.91865239
39Recurrent viral infections (HP:0004429)2.88637582
40Colitis (HP:0002583)2.87762541
41Abnormality of complement system (HP:0005339)2.86936933
42Nephritis (HP:0000123)2.85342767
43Glomerulopathy (HP:0100820)2.84598714
44Recurrent gram-negative bacterial infections (HP:0005420)2.77957767
45Pulmonary fibrosis (HP:0002206)2.77322773
46Ureteral obstruction (HP:0006000)2.77255551
47Pulmonary embolism (HP:0002204)2.75774737
48Retrobulbar optic neuritis (HP:0100654)2.70388410
49Optic neuritis (HP:0100653)2.70388410
50Lymphopenia (HP:0001888)2.68775377
51Abnormality of the pericardium (HP:0001697)2.68005049
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.62327647
53Orchitis (HP:0100796)2.62027684
54IgG deficiency (HP:0004315)2.60230567
55Xerostomia (HP:0000217)2.55734368
56Cellulitis (HP:0100658)2.53442321
57Inflammation of the large intestine (HP:0002037)2.48038175
58Petechiae (HP:0000967)2.45346224
59Abnormality of male internal genitalia (HP:0000022)2.44778415
60Hypergammaglobulinemia (HP:0010702)2.43064197
61Recurrent pneumonia (HP:0006532)2.42976237
62Cerebral palsy (HP:0100021)2.42540470
63Fatigue (HP:0012378)2.40880325
64Increased cerebral lipofuscin (HP:0011813)2.40637498
65IgM deficiency (HP:0002850)2.39013217
66Skin ulcer (HP:0200042)2.37573852
67Polyneuropathy (HP:0001271)2.37539259
68Encephalitis (HP:0002383)2.35481422
69Abnormality of B cell number (HP:0010975)2.34617409
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.33926349
71Papilloma (HP:0012740)2.33905367
72Verrucae (HP:0200043)2.33905367
73Epistaxis (HP:0000421)2.32464784
74Osteomyelitis (HP:0002754)2.32175576
75Gastrointestinal inflammation (HP:0004386)2.31342133
76Pruritus (HP:0000989)2.29072849
77IgA deficiency (HP:0002720)2.28523573
78Recurrent lower respiratory tract infections (HP:0002783)2.26500869
79Paresthesia (HP:0003401)2.21862103
80Pustule (HP:0200039)2.20734425
81Purpura (HP:0000979)2.18870265
82Arthralgia (HP:0002829)2.17300340
83Keratoconjunctivitis sicca (HP:0001097)2.16024969
84Anorexia (HP:0002039)2.14635895
85Abnormality of liposaccharide metabolism (HP:0010968)2.14616467
86Abnormality of glycosphingolipid metabolism (HP:0004343)2.14616467
87Abnormality of glycolipid metabolism (HP:0010969)2.14616467
88Hypertensive crisis (HP:0100735)2.14002381
89Malnutrition (HP:0004395)2.12900661
90Premature loss of primary teeth (HP:0006323)2.12751106
91Abnormality of T cell number (HP:0011839)2.11809648
92Chronic otitis media (HP:0000389)2.11549156
93Arterial thrombosis (HP:0004420)2.11225050
94Thrombophlebitis (HP:0004418)2.11091735
95Spontaneous hematomas (HP:0007420)2.10057850
96B lymphocytopenia (HP:0010976)2.08253884
97Gingivitis (HP:0000230)2.05929250
98Chronic sinusitis (HP:0011109)2.03946030
99Amaurosis fugax (HP:0100576)2.03676229
100Basal ganglia calcification (HP:0002135)2.03458870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR24.38052970
2RIPK44.18282265
3MAP4K14.05018386
4CDK193.85435644
5BLK3.48485336
6MAP3K143.09125561
7TYK22.77373108
8CSF1R2.50544510
9MAP3K122.43069051
10KIT2.33972568
11JAK32.28437747
12SYK2.20108687
13MAP3K132.11015536
14PRPF4B2.04219140
15IKBKB1.96594314
16BTK1.84598762
17TAOK31.84154819
18JAK11.80340642
19IRAK41.72400313
20MATK1.70909939
21LYN1.67680177
22CSK1.67463275
23TBK11.62479773
24IKBKE1.54690732
25TLK11.54237032
26ERN11.43139831
27STK241.41551156
28GRK61.34212617
29FES1.31169778
30MYLK1.30952114
31TXK1.24388717
32HCK1.19227674
33ITK1.17225371
34FGR1.16780040
35TAOK21.15039854
36FGFR41.14349951
37TEC1.13401357
38MAP3K31.11680837
39SIK21.09792399
40RIPK11.06870472
41LCK1.05321111
42SIK31.01770250
43JAK21.00889825
44ZAP701.00037098
45FGFR30.98275078
46IRAK10.90107346
47TRPM70.86382266
48EIF2AK30.83087791
49NME20.82109072
50CDC42BPA0.81206639
51CHUK0.80862103
52OXSR10.80749016
53MARK30.76687314
54DAPK30.76446903
55MST40.75516653
56IRAK30.73943832
57PRKCQ0.73458244
58ILK0.71784848
59MAP2K30.70134958
60PDK10.65743807
61SCYL20.65426061
62GRK70.62299791
63KDR0.58464078
64MAP3K100.58272492
65IRAK20.57809880
66DDR20.57663280
67MAPK70.55779262
68ABL10.54311688
69PIM10.54168612
70TNK20.53517397
71HIPK20.52248486
72EPHA30.52005775
73MAPK120.49861803
74PDPK10.48101390
75PIK3CG0.48061584
76CCNB10.48025835
77PRKCD0.47796833
78DAPK10.46263679
79EGFR0.45346770
80MAP4K20.43547148
81FYN0.42483306
82LRRK20.40297964
83SMG10.40136622
84RPS6KA50.39707165
85MAP3K10.39178737
86NEK90.37251685
87IGF1R0.36633966
88PKN10.35063084
89EPHB10.31971633
90MAPK40.30007910
91TAOK10.29167248
92PAK40.27425662
93MAPK110.26813414
94BRD40.25722460
95BCKDK0.25509552
96ACVR1B0.24909481
97MAPKAPK20.24585033
98INSR0.22062763
99YES10.20178871
100PRKG20.19071252

Predicted pathways (KEGG)

RankGene SetZ-score
1* Asthma_Homo sapiens_hsa053106.15259503
2* Allograft rejection_Homo sapiens_hsa053305.35685531
3* Autoimmune thyroid disease_Homo sapiens_hsa053204.98339626
4* Graft-versus-host disease_Homo sapiens_hsa053324.90023194
5* Intestinal immune network for IgA production_Homo sapiens_hsa046724.66631553
6* Type I diabetes mellitus_Homo sapiens_hsa049404.24233529
7* Staphylococcus aureus infection_Homo sapiens_hsa051503.54736434
8* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.15297864
9* Viral myocarditis_Homo sapiens_hsa054163.09396792
10* Leishmaniasis_Homo sapiens_hsa051403.03448494
11* Antigen processing and presentation_Homo sapiens_hsa046122.88995138
12* Rheumatoid arthritis_Homo sapiens_hsa053232.41096820
13* Toxoplasmosis_Homo sapiens_hsa051451.73678701
14* Tuberculosis_Homo sapiens_hsa051521.71168474
15Primary immunodeficiency_Homo sapiens_hsa053401.67071298
16* Influenza A_Homo sapiens_hsa051641.50750561
17* Systemic lupus erythematosus_Homo sapiens_hsa053221.48014666
18Hematopoietic cell lineage_Homo sapiens_hsa046401.44033458
19* Herpes simplex infection_Homo sapiens_hsa051681.37967978
20* Phagosome_Homo sapiens_hsa041451.30315589
21* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19327885
22B cell receptor signaling pathway_Homo sapiens_hsa046621.19029516
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.14229739
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10391651
25Osteoclast differentiation_Homo sapiens_hsa043801.02951682
26* Epstein-Barr virus infection_Homo sapiens_hsa051690.84964016
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80364413
28Pertussis_Homo sapiens_hsa051330.78866632
29NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73749683
30African trypanosomiasis_Homo sapiens_hsa051430.69879044
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68216449
32Measles_Homo sapiens_hsa051620.65542662
33Legionellosis_Homo sapiens_hsa051340.64410511
34Salmonella infection_Homo sapiens_hsa051320.60955291
35Chemokine signaling pathway_Homo sapiens_hsa040620.60917720
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58709225
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55846666
38Malaria_Homo sapiens_hsa051440.51133119
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48010186
40TNF signaling pathway_Homo sapiens_hsa046680.47218112
41* HTLV-I infection_Homo sapiens_hsa051660.45897639
42Jak-STAT signaling pathway_Homo sapiens_hsa046300.44954805
43T cell receptor signaling pathway_Homo sapiens_hsa046600.42969487
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40043809
45Other glycan degradation_Homo sapiens_hsa005110.39213543
46Shigellosis_Homo sapiens_hsa051310.37833370
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37707114
48Lysosome_Homo sapiens_hsa041420.32326553
49Collecting duct acid secretion_Homo sapiens_hsa049660.31597178
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31472923
51Renin-angiotensin system_Homo sapiens_hsa046140.30318808
52Hepatitis C_Homo sapiens_hsa051600.27116316
53Ribosome_Homo sapiens_hsa030100.27045178
54Oxidative phosphorylation_Homo sapiens_hsa001900.26996485
55Regulation of autophagy_Homo sapiens_hsa041400.26956797
56Platelet activation_Homo sapiens_hsa046110.26771714
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.26408020
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24117915
59Hepatitis B_Homo sapiens_hsa051610.23978116
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21172809
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.19836787
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18789745
63Apoptosis_Homo sapiens_hsa042100.18302153
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17559475
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16528044
66Arachidonic acid metabolism_Homo sapiens_hsa005900.15219082
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15030856
68Linoleic acid metabolism_Homo sapiens_hsa005910.12651958
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10269669
70Proteasome_Homo sapiens_hsa030500.08925646
71Viral carcinogenesis_Homo sapiens_hsa052030.08650880
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.07695869
73Fat digestion and absorption_Homo sapiens_hsa049750.06841580
74Parkinsons disease_Homo sapiens_hsa050120.06379322
75Acute myeloid leukemia_Homo sapiens_hsa052210.06215276
76Ether lipid metabolism_Homo sapiens_hsa005650.04029382
77Vitamin digestion and absorption_Homo sapiens_hsa049770.03312269
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.03213400
79Galactose metabolism_Homo sapiens_hsa000520.01038557
80Histidine metabolism_Homo sapiens_hsa003400.00903217
81Alzheimers disease_Homo sapiens_hsa050100.00392288
82Amoebiasis_Homo sapiens_hsa051460.00374847
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.00168022
84GnRH signaling pathway_Homo sapiens_hsa04912-0.0587626
85Salivary secretion_Homo sapiens_hsa04970-0.0581321
86Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0520695
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980-0.0519387
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770-0.0508243
89Vibrio cholerae infection_Homo sapiens_hsa05110-0.0492271
90Complement and coagulation cascades_Homo sapiens_hsa04610-0.0420234
91PPAR signaling pathway_Homo sapiens_hsa03320-0.0375226
92Prolactin signaling pathway_Homo sapiens_hsa04917-0.0361381
93Starch and sucrose metabolism_Homo sapiens_hsa00500-0.0286680
94Tryptophan metabolism_Homo sapiens_hsa00380-0.0257389
95Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0188373
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0167992
97Endocytosis_Homo sapiens_hsa04144-0.0119876
98Mineral absorption_Homo sapiens_hsa04978-0.0075110
99Bladder cancer_Homo sapiens_hsa05219-0.0047206
100Chemical carcinogenesis_Homo sapiens_hsa05204-0.0029027

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