HLA-DQA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)4.98210011
2immunoglobulin mediated immune response (GO:0016064)4.74508648
3* interferon-gamma-mediated signaling pathway (GO:0060333)4.34749484
4positive regulation of gamma-delta T cell activation (GO:0046645)4.31992581
5B cell receptor signaling pathway (GO:0050853)4.29504879
6regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.23438276
7regulation of antigen processing and presentation (GO:0002577)4.13513314
8positive regulation of antigen processing and presentation (GO:0002579)4.01989700
9antigen processing and presentation of endogenous antigen (GO:0019883)3.96234244
10regulation of dendritic cell antigen processing and presentation (GO:0002604)3.95824920
11T-helper 1 type immune response (GO:0042088)3.88273825
12indole-containing compound catabolic process (GO:0042436)3.82659514
13indolalkylamine catabolic process (GO:0046218)3.82659514
14tryptophan catabolic process (GO:0006569)3.82659514
15cellular response to exogenous dsRNA (GO:0071360)3.65874543
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.65218198
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.63760882
18regulation of gamma-delta T cell activation (GO:0046643)3.58552966
19detection of bacterium (GO:0016045)3.49726083
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.47512152
21cellular response to ethanol (GO:0071361)3.47099754
22B cell mediated immunity (GO:0019724)3.46970090
23response to type I interferon (GO:0034340)3.46717889
24regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.44603159
25positive regulation by symbiont of host defense response (GO:0052509)3.44319839
26modulation by symbiont of host defense response (GO:0052031)3.44319839
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.44319839
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.44319839
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.44319839
30modulation by symbiont of host immune response (GO:0052553)3.44319839
31detection of other organism (GO:0098543)3.38436492
32kynurenine metabolic process (GO:0070189)3.38216937
33CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.34432731
34positive regulation of developmental pigmentation (GO:0048087)3.33689059
35macrophage activation involved in immune response (GO:0002281)3.33630666
36type I interferon signaling pathway (GO:0060337)3.33247492
37cellular response to type I interferon (GO:0071357)3.33247492
38interkinetic nuclear migration (GO:0022027)3.30684225
39tryptophan metabolic process (GO:0006568)3.21990256
40* cellular response to interferon-gamma (GO:0071346)3.21989504
41indolalkylamine metabolic process (GO:0006586)3.20123745
42negative regulation of cell killing (GO:0031342)3.14430301
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.14430301
44regulation of interleukin-12 biosynthetic process (GO:0045075)3.14262244
45positive regulation of mast cell activation (GO:0033005)3.13411291
46* T cell costimulation (GO:0031295)3.12597135
47regulation of pigment cell differentiation (GO:0050932)3.09559317
48positive regulation of interferon-alpha production (GO:0032727)3.09045560
49* lymphocyte costimulation (GO:0031294)3.07815946
50B cell homeostasis (GO:0001782)3.05868932
51regulation of interferon-beta biosynthetic process (GO:0045357)3.04600231
52regulation of interferon-alpha production (GO:0032647)3.02642332
53regulation of MHC class I biosynthetic process (GO:0045343)3.01600615
54negative thymic T cell selection (GO:0045060)3.01213431
55defense response to protozoan (GO:0042832)2.99349963
56* response to interferon-gamma (GO:0034341)2.94763949
57snRNA transcription (GO:0009301)2.94107377
58microglial cell activation (GO:0001774)2.93422675
59positive thymic T cell selection (GO:0045059)2.90677077
60response to protozoan (GO:0001562)2.89224563
61regulation of alpha-beta T cell proliferation (GO:0046640)2.88315521
62positive regulation of defense response to virus by host (GO:0002230)2.87856817
63regulation of gamma-delta T cell differentiation (GO:0045586)2.87326364
64negative T cell selection (GO:0043383)2.86548714
65positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.85567066
66regulation of germinal center formation (GO:0002634)2.83635487
67germinal center formation (GO:0002467)2.83137950
68adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.81837766
69regulation of B cell proliferation (GO:0030888)2.81256677
70T cell migration (GO:0072678)2.80694859
71adaptive immune response (GO:0002250)2.79832650
72regulation of T-helper 1 cell differentiation (GO:0045625)2.79810526
73detection of external biotic stimulus (GO:0098581)2.76232304
74positive regulation of interleukin-12 production (GO:0032735)2.75533720
75regulation of mast cell activation (GO:0033003)2.75456557
76monoubiquitinated protein deubiquitination (GO:0035520)2.74657389
77negative regulation of interleukin-12 production (GO:0032695)2.72945465
78protein K48-linked deubiquitination (GO:0071108)2.70898730
79positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.70704454
80positive regulation of type 2 immune response (GO:0002830)2.67485623
81positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.65943711
82regulation of interleukin-12 production (GO:0032655)2.64990901
83positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.62985494
84production of molecular mediator of immune response (GO:0002440)2.62493726
85positive regulation of mast cell activation involved in immune response (GO:0033008)2.62239433
86positive regulation of mast cell degranulation (GO:0043306)2.62239433
87positive regulation of B cell proliferation (GO:0030890)2.61694134
88positive regulation of B cell differentiation (GO:0045579)2.61494859
89regulation of hypersensitivity (GO:0002883)2.60987548
90positive T cell selection (GO:0043368)2.58438479
91* antigen receptor-mediated signaling pathway (GO:0050851)2.57811713
92negative regulation of T cell mediated immunity (GO:0002710)2.57419253
93regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.55218322
94interferon-gamma secretion (GO:0072643)2.54526410
95response to host immune response (GO:0052572)2.53422719
96response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.53422719
97striated muscle atrophy (GO:0014891)2.52824596
98B cell proliferation (GO:0042100)2.52665809
99regulation of interferon-gamma biosynthetic process (GO:0045072)2.51772076
100regulation of B cell differentiation (GO:0045577)2.51135849

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.64985403
2EZH2_22144423_ChIP-Seq_EOC_Human3.46751881
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.34359314
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.20519572
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.13115690
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43771994
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.37663609
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25851350
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24701766
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.17952213
11RUNX_20019798_ChIP-Seq_JUKART_Human1.89322608
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81453992
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80708763
14GBX2_23144817_ChIP-Seq_PC3_Human1.77862487
15SCL_19346495_ChIP-Seq_HPC-7_Human1.76089779
16VDR_22108803_ChIP-Seq_LS180_Human1.75739933
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73026340
18VDR_24787735_ChIP-Seq_THP-1_Human1.72069524
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71384625
20* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.67605601
21ZNF274_21170338_ChIP-Seq_K562_Hela1.64053009
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62729822
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62496030
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62485047
25DROSHA_22980978_ChIP-Seq_HELA_Human1.60623001
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.58210283
27AR_21572438_ChIP-Seq_LNCaP_Human1.47768647
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46032311
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45359846
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44728307
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43862542
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41971409
33TP53_16413492_ChIP-PET_HCT116_Human1.40405471
34NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.39713219
35GATA1_22025678_ChIP-Seq_K562_Human1.39693177
36STAT3_23295773_ChIP-Seq_U87_Human1.37584687
37MYB_26560356_Chip-Seq_TH2_Human1.36532764
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.36185556
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35974883
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35974883
41PRDM14_20953172_ChIP-Seq_ESCs_Human1.34484146
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.31904149
43SMRT_27268052_Chip-Seq_Bcells_Human1.28703939
44ER_23166858_ChIP-Seq_MCF-7_Human1.25309000
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24226157
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23728723
47VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23583554
48AHR_22903824_ChIP-Seq_MCF-7_Human1.22052855
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21581764
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.21576503
51GATA3_26560356_Chip-Seq_TH2_Human1.21178723
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20347387
53TCF4_23295773_ChIP-Seq_U87_Human1.19637888
54BCAT_22108803_ChIP-Seq_LS180_Human1.19241819
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18348429
56GATA3_27048872_Chip-Seq_THYMUS_Human1.15762485
57TAF15_26573619_Chip-Seq_HEK293_Human1.14023924
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12936971
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10706699
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10315729
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10102604
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09579630
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09420418
64SPI1_23127762_ChIP-Seq_K562_Human1.09371262
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.08714002
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06879042
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06471749
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06163502
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05601652
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.04737282
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04576314
72RXR_22108803_ChIP-Seq_LS180_Human1.03560978
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01544040
74SMAD4_21799915_ChIP-Seq_A2780_Human1.01135127
75MYB_26560356_Chip-Seq_TH1_Human1.00802243
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00758926
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00663478
78AR_25329375_ChIP-Seq_VCAP_Human0.99196233
79P300_19829295_ChIP-Seq_ESCs_Human0.98529610
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98166223
81EWS_26573619_Chip-Seq_HEK293_Human0.94689356
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94256658
83VDR_24763502_ChIP-Seq_THP-1_Human0.92983540
84SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92789303
85IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92644449
86OCT1_27270436_Chip-Seq_PROSTATE_Human0.92562145
87STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91765695
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90446005
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89585650
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.89528316
91NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89252350
92KDM2B_26808549_Chip-Seq_REH_Human0.87281404
93CBP_20019798_ChIP-Seq_JUKART_Human0.87000488
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87000488
95FLI1_21867929_ChIP-Seq_TH2_Mouse0.86448230
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84878895
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83992170
98REST_21632747_ChIP-Seq_MESCs_Mouse0.83088886
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82975687
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80753230

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.43051605
2MP0005671_abnormal_response_to3.97450871
3MP0000685_abnormal_immune_system3.66171390
4MP0001800_abnormal_humoral_immune3.59283049
5MP0005387_immune_system_phenotype3.51810848
6MP0001790_abnormal_immune_system3.51810848
7MP0000569_abnormal_digit_pigmentation3.30575275
8MP0002138_abnormal_hepatobiliary_system3.08556859
9MP0003303_peritoneal_inflammation2.85228328
10MP0002452_abnormal_antigen_presenting2.76106144
11MP0005000_abnormal_immune_tolerance2.65171590
12MP0002723_abnormal_immune_serum2.59906781
13MP0002148_abnormal_hypersensitivity_rea2.51797176
14MP0005310_abnormal_salivary_gland2.43189280
15MP0009785_altered_susceptibility_to2.29697233
16MP0002420_abnormal_adaptive_immunity2.26554397
17MP0001819_abnormal_immune_cell2.25421751
18MP0003724_increased_susceptibility_to2.24660079
19MP0005025_abnormal_response_to2.24072480
20MP0008057_abnormal_DNA_replication2.23798255
21MP0003646_muscle_fatigue2.21186737
22MP0003183_abnormal_peptide_metabolism2.07144666
23MP0002419_abnormal_innate_immunity2.06847674
24MP0003436_decreased_susceptibility_to1.95997418
25MP0003045_fibrosis1.91436868
26MP0010155_abnormal_intestine_physiology1.86975300
27MP0003763_abnormal_thymus_physiology1.79171924
28MP0000716_abnormal_immune_system1.78396125
29MP0006082_CNS_inflammation1.73093771
30MP0003195_calcinosis1.70697478
31MP0001873_stomach_inflammation1.69591993
32MP0005645_abnormal_hypothalamus_physiol1.58975009
33MP0002405_respiratory_system_inflammati1.57780866
34MP0002398_abnormal_bone_marrow1.56452137
35MP0009764_decreased_sensitivity_to1.56308962
36MP0001845_abnormal_inflammatory_respons1.55121623
37MP0002166_altered_tumor_susceptibility1.51824281
38MP0004043_abnormal_pH_regulation1.41799804
39MP0000689_abnormal_spleen_morphology1.39985805
40MP0009046_muscle_twitch1.36455168
41MP0001501_abnormal_sleep_pattern1.33687069
42MP0008961_abnormal_basal_metabolism1.31951179
43MP0003866_abnormal_defecation1.25376116
44MP0003300_gastrointestinal_ulcer1.23630152
45MP0002429_abnormal_blood_cell1.23560155
46MP0001986_abnormal_taste_sensitivity1.22577390
47MP0005174_abnormal_tail_pigmentation1.13361210
48MP0008469_abnormal_protein_level1.08794391
49MP0002722_abnormal_immune_system1.08608872
50MP0004947_skin_inflammation1.07874892
51MP0003252_abnormal_bile_duct1.07072213
52MP0005167_abnormal_blood-brain_barrier1.06375527
53MP0001663_abnormal_digestive_system1.05541150
54MP0008872_abnormal_physiological_respon1.01057379
55MP0009115_abnormal_fat_cell0.96703118
56MP0001533_abnormal_skeleton_physiology0.96193922
57MP0002006_tumorigenesis0.94282426
58MP0004145_abnormal_muscle_electrophysio0.91692925
59MP0004130_abnormal_muscle_cell0.91317755
60MP0000371_diluted_coat_color0.91181591
61MP0009333_abnormal_splenocyte_physiolog0.89037911
62MP0004142_abnormal_muscle_tone0.89033465
63MP0002998_abnormal_bone_remodeling0.88472568
64MP0002928_abnormal_bile_duct0.87823157
65MP0000015_abnormal_ear_pigmentation0.87529905
66MP0002693_abnormal_pancreas_physiology0.86549549
67MP0002136_abnormal_kidney_physiology0.84717685
68MP0004381_abnormal_hair_follicle0.82209752
69MP0000427_abnormal_hair_cycle0.81367332
70MP0002168_other_aberrant_phenotype0.80788549
71MP0002735_abnormal_chemical_nociception0.78264403
72MP0000470_abnormal_stomach_morphology0.74679561
73MP0009745_abnormal_behavioral_response0.73238607
74MP0004510_myositis0.72793305
75MP0000249_abnormal_blood_vessel0.72549049
76MP0002933_joint_inflammation0.72361232
77MP0002139_abnormal_hepatobiliary_system0.72058632
78MP0000703_abnormal_thymus_morphology0.71817351
79MP0002009_preneoplasia0.71570670
80MP0005266_abnormal_metabolism0.71524255
81MP0002396_abnormal_hematopoietic_system0.71219050
82MP0005464_abnormal_platelet_physiology0.70144095
83MP0001440_abnormal_grooming_behavior0.69099062
84MP0002095_abnormal_skin_pigmentation0.67279119
85MP0002277_abnormal_respiratory_mucosa0.67274247
86MP0005551_abnormal_eye_electrophysiolog0.66967647
87MP0001485_abnormal_pinna_reflex0.66320494
88MP0004742_abnormal_vestibular_system0.65741930
89MP0005647_abnormal_sex_gland0.64981116
90MP0005085_abnormal_gallbladder_physiolo0.63699477
91MP0000383_abnormal_hair_follicle0.63524863
92MP0002064_seizures0.62818771
93MP0001853_heart_inflammation0.62591048
94MP0003172_abnormal_lysosome_physiology0.60629873
95MP0003633_abnormal_nervous_system0.60306106
96MP0001968_abnormal_touch/_nociception0.60031926
97MP0005448_abnormal_energy_balance0.59193273
98MP0000230_abnormal_systemic_arterial0.59040528
99MP0001545_abnormal_hematopoietic_system0.58056828
100MP0005397_hematopoietic_system_phenotyp0.58056828

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)4.50338810
2Gastrointestinal stroma tumor (HP:0100723)4.18985974
3Agammaglobulinemia (HP:0004432)3.95197189
4Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.83243567
5Abnormal delayed hypersensitivity skin test (HP:0002963)3.80331724
6Recurrent sinusitis (HP:0011108)3.78838014
7Increased neuronal autofluorescent lipopigment (HP:0002074)3.76697254
8Hyperventilation (HP:0002883)3.63274894
9Recurrent bronchitis (HP:0002837)3.56481558
10Recurrent bacterial skin infections (HP:0005406)3.49602723
11Chronic mucocutaneous candidiasis (HP:0002728)3.48330304
12Recurrent cutaneous fungal infections (HP:0011370)3.48330304
13Vasculitis (HP:0002633)3.48221493
14Clumsiness (HP:0002312)3.46637685
15Increased cerebral lipofuscin (HP:0011813)3.44476173
16Colitis (HP:0002583)3.42245916
17Meningitis (HP:0001287)3.38244516
18Progressive cerebellar ataxia (HP:0002073)3.34244197
19Mediastinal lymphadenopathy (HP:0100721)3.30272046
20Panhypogammaglobulinemia (HP:0003139)3.17985807
21Recurrent fungal infections (HP:0002841)3.15070095
22IgA deficiency (HP:0002720)3.09022289
23Protruding tongue (HP:0010808)3.08917739
24Recurrent abscess formation (HP:0002722)3.00212973
25Chronic otitis media (HP:0000389)2.94235334
26Pulmonary infiltrates (HP:0002113)2.94054646
27Gaze-evoked nystagmus (HP:0000640)2.93144285
28Recurrent viral infections (HP:0004429)2.80461669
29Recurrent skin infections (HP:0001581)2.75454083
30Eczematoid dermatitis (HP:0000976)2.71496321
31Decreased circulating renin level (HP:0003351)2.68477620
32Hemoptysis (HP:0002105)2.67003812
33Chronic diarrhea (HP:0002028)2.65209110
34Pancreatic cysts (HP:0001737)2.63502016
35Abnormality of the prostate (HP:0008775)2.62906757
36Lymphopenia (HP:0001888)2.60199651
37Inflammation of the large intestine (HP:0002037)2.56420909
38Encephalitis (HP:0002383)2.54307010
39Autoimmune thrombocytopenia (HP:0001973)2.53965773
40Retrobulbar optic neuritis (HP:0100654)2.53901496
41Optic neuritis (HP:0100653)2.53901496
42Abnormality of cells of the lymphoid lineage (HP:0012140)2.47172079
43Restrictive lung disease (HP:0002091)2.45202193
44Abnormality of binocular vision (HP:0011514)2.44760580
45Diplopia (HP:0000651)2.44760580
46IgG deficiency (HP:0004315)2.43156306
47Recurrent pneumonia (HP:0006532)2.41653180
48Emphysema (HP:0002097)2.39194695
49Fair hair (HP:0002286)2.33414355
50Stomach cancer (HP:0012126)2.32520985
51Congenital stationary night blindness (HP:0007642)2.28407280
52Gastrointestinal inflammation (HP:0004386)2.26866459
53Abnormality of B cell number (HP:0010975)2.26191397
54Abnormality of macrophages (HP:0004311)2.26122219
55Abnormality of T cell physiology (HP:0011840)2.25157227
56IgM deficiency (HP:0002850)2.24164076
57Bronchitis (HP:0012387)2.21391002
58Abnormality of T cell number (HP:0011839)2.19820377
59Orchitis (HP:0100796)2.18203656
60Chronic sinusitis (HP:0011109)2.16694946
61Abnormality of the pleura (HP:0002103)2.15029699
62Abnormality of T cells (HP:0002843)2.13865009
63Chronic hepatic failure (HP:0100626)2.13420716
64Recurrent lower respiratory tract infections (HP:0002783)2.13198770
65Spontaneous hematomas (HP:0007420)2.10522595
66Gastrointestinal infarctions (HP:0005244)2.08361546
67Myositis (HP:0100614)2.06311367
68Abnormality of the axillary hair (HP:0100134)2.05257161
69Abnormality of secondary sexual hair (HP:0009888)2.05257161
70Prostate neoplasm (HP:0100787)2.04712015
71Attenuation of retinal blood vessels (HP:0007843)2.00842014
72Pancreatic fibrosis (HP:0100732)2.00163420
73Recurrent gram-negative bacterial infections (HP:0005420)1.98842532
74Elevated erythrocyte sedimentation rate (HP:0003565)1.98449586
75Urticaria (HP:0001025)1.96694299
76True hermaphroditism (HP:0010459)1.95839696
77Chronic obstructive pulmonary disease (HP:0006510)1.94832264
78Obstructive lung disease (HP:0006536)1.94832264
79Generalized hypopigmentation of hair (HP:0011358)1.94046143
80Dysmetric saccades (HP:0000641)1.92391927
81Congenital sensorineural hearing impairment (HP:0008527)1.92064804
82T lymphocytopenia (HP:0005403)1.91381112
83Tubular atrophy (HP:0000092)1.91177483
84Pustule (HP:0200039)1.88694177
85Systemic lupus erythematosus (HP:0002725)1.86115615
86Chest pain (HP:0100749)1.82561960
87Abnormality of the fingertips (HP:0001211)1.81951615
88Inability to walk (HP:0002540)1.80995491
89Furrowed tongue (HP:0000221)1.80931497
90Abnormality of male internal genitalia (HP:0000022)1.79994013
91Cellulitis (HP:0100658)1.78694023
92Papilloma (HP:0012740)1.77691857
93Verrucae (HP:0200043)1.77691857
94Widely spaced teeth (HP:0000687)1.77253465
95Viral hepatitis (HP:0006562)1.76824883
96Progressive inability to walk (HP:0002505)1.76684556
97Autoimmune hemolytic anemia (HP:0001890)1.76122743
98Hypoplastic ischia (HP:0003175)1.75737794
99Hemiplegia (HP:0002301)1.75005081
100Abnormality of midbrain morphology (HP:0002418)1.74444110

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.92981037
2ACVR1B3.40921104
3BLK3.38537695
4RIPK43.15560061
5MAP4K13.07050147
6TAOK32.20887436
7BMPR1B2.01209555
8KIT2.00780834
9ADRBK21.96473878
10MAP3K141.94818424
11SIK21.94418820
12SYK1.83823673
13TYK21.72716102
14IKBKB1.72173501
15IKBKE1.71048220
16CSF1R1.64080737
17TLK11.57206015
18IRAK41.55611292
19MAP3K131.54274809
20BTK1.53866742
21JAK11.50336133
22TEC1.41610705
23CHUK1.40207666
24LYN1.25463019
25CDC42BPA1.23916184
26JAK31.23394780
27INSRR1.22507928
28BMPR21.21566704
29TXK1.13509862
30NEK91.08567459
31SGK21.05261432
32CSK1.04900670
33PIK3CG1.04365307
34CDK121.03763319
35MATK1.03581957
36TGFBR10.99230568
37TRPM70.98419608
38STK240.97358081
39ITK0.97130260
40IRAK10.96989589
41OXSR10.95997650
42GRK10.95432701
43TBK10.92560964
44PRKCQ0.92156542
45TNK20.91277497
46LCK0.87754039
47MELK0.86126740
48DAPK20.85531270
49GRK70.83113176
50HCK0.79538336
51FGFR30.79366271
52ERN10.79190110
53MAPK110.78880291
54CAMK1D0.78293823
55ADRBK10.76842339
56MARK30.71452353
57MAP3K70.70378648
58MAPK70.70331580
59CAMK1G0.69761903
60BRD40.69593781
61FES0.69152203
62JAK20.66063679
63FGR0.64147203
64ZAK0.63931741
65PDK10.63695363
66NLK0.63382443
67PTK2B0.63126733
68CDK190.62297263
69MAPK130.58546177
70MAPK120.58542172
71RPS6KA60.58537036
72AKT30.58274602
73PRKCH0.56472295
74PIM10.55555287
75SGK30.53703452
76MKNK20.53377824
77PRKAA20.52112329
78PKN10.51277434
79PRPF4B0.49809572
80ZAP700.49434008
81CAMKK20.48865982
82SGK2230.48472353
83SGK4940.48472353
84EPHA30.47005039
85NTRK30.46984036
86STK110.46912557
87HIPK20.45764076
88STK30.45556279
89RPS6KA50.44959153
90PIK3CA0.44892548
91ABL10.42917881
92SGK10.41578077
93MARK20.39402443
94CAMKK10.37556133
95FGFR40.37194916
96TNIK0.35514704
97STK38L0.35034817
98WNK10.35001051
99PDPK10.34965070
100MAPKAPK30.33781132

Predicted pathways (KEGG)

RankGene SetZ-score
1* Asthma_Homo sapiens_hsa053104.51381886
2* Intestinal immune network for IgA production_Homo sapiens_hsa046724.38056787
3* Allograft rejection_Homo sapiens_hsa053304.24420124
4* Graft-versus-host disease_Homo sapiens_hsa053324.08750027
5* Autoimmune thyroid disease_Homo sapiens_hsa053203.94151889
6* Type I diabetes mellitus_Homo sapiens_hsa049403.27258286
7* Staphylococcus aureus infection_Homo sapiens_hsa051503.08184219
8* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.79077995
9* Leishmaniasis_Homo sapiens_hsa051402.41230139
10* Antigen processing and presentation_Homo sapiens_hsa046122.20400235
11Primary immunodeficiency_Homo sapiens_hsa053402.20351730
12* Viral myocarditis_Homo sapiens_hsa054162.06628298
13B cell receptor signaling pathway_Homo sapiens_hsa046621.82609424
14* Rheumatoid arthritis_Homo sapiens_hsa053231.64794221
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.59759905
16* Systemic lupus erythematosus_Homo sapiens_hsa053221.57575418
17* Tuberculosis_Homo sapiens_hsa051521.52900120
18* Toxoplasmosis_Homo sapiens_hsa051451.48699321
19Hematopoietic cell lineage_Homo sapiens_hsa046401.38732850
20* Influenza A_Homo sapiens_hsa051641.37611236
21Osteoclast differentiation_Homo sapiens_hsa043801.27157317
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24022417
23* Herpes simplex infection_Homo sapiens_hsa051681.18553180
24* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16715592
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12123751
26Linoleic acid metabolism_Homo sapiens_hsa005911.03682841
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99394537
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92125672
29ABC transporters_Homo sapiens_hsa020100.91797669
30Tryptophan metabolism_Homo sapiens_hsa003800.88499609
31TNF signaling pathway_Homo sapiens_hsa046680.86954371
32NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86562123
33Measles_Homo sapiens_hsa051620.86324460
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85712884
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83375122
36Dorso-ventral axis formation_Homo sapiens_hsa043200.83330365
37Chemokine signaling pathway_Homo sapiens_hsa040620.83031420
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81548513
39Jak-STAT signaling pathway_Homo sapiens_hsa046300.81436745
40African trypanosomiasis_Homo sapiens_hsa051430.75912856
41Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75359921
42T cell receptor signaling pathway_Homo sapiens_hsa046600.72812892
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71248361
44* Phagosome_Homo sapiens_hsa041450.71248217
45Ether lipid metabolism_Homo sapiens_hsa005650.66460925
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61743022
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59038793
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58921262
49Platelet activation_Homo sapiens_hsa046110.56706009
50Type II diabetes mellitus_Homo sapiens_hsa049300.56094914
51Hepatitis C_Homo sapiens_hsa051600.55936413
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55745228
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55515256
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54273948
55Nicotine addiction_Homo sapiens_hsa050330.53994198
56Pertussis_Homo sapiens_hsa051330.53500341
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53256490
58* Epstein-Barr virus infection_Homo sapiens_hsa051690.53242574
59Histidine metabolism_Homo sapiens_hsa003400.49491901
60Phototransduction_Homo sapiens_hsa047440.49180701
61Glycerolipid metabolism_Homo sapiens_hsa005610.46952349
62Prolactin signaling pathway_Homo sapiens_hsa049170.46940295
63Taste transduction_Homo sapiens_hsa047420.46752215
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46729973
65Lysosome_Homo sapiens_hsa041420.46226566
66Cholinergic synapse_Homo sapiens_hsa047250.45491583
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.44018946
68Serotonergic synapse_Homo sapiens_hsa047260.43808512
69Morphine addiction_Homo sapiens_hsa050320.42778500
70Long-term depression_Homo sapiens_hsa047300.42105375
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42001269
72Calcium signaling pathway_Homo sapiens_hsa040200.41044565
73MAPK signaling pathway_Homo sapiens_hsa040100.40733431
74Glutamatergic synapse_Homo sapiens_hsa047240.39170664
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37404584
76Hepatitis B_Homo sapiens_hsa051610.37297728
77Malaria_Homo sapiens_hsa051440.36285863
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.35702264
79Ovarian steroidogenesis_Homo sapiens_hsa049130.35532519
80Oxytocin signaling pathway_Homo sapiens_hsa049210.34346382
81* HTLV-I infection_Homo sapiens_hsa051660.33607122
82Arachidonic acid metabolism_Homo sapiens_hsa005900.33268325
83Salivary secretion_Homo sapiens_hsa049700.32558502
84Apoptosis_Homo sapiens_hsa042100.32223573
85Nitrogen metabolism_Homo sapiens_hsa009100.29890706
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.29517360
87Circadian entrainment_Homo sapiens_hsa047130.29235352
88Olfactory transduction_Homo sapiens_hsa047400.27994955
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.26316217
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25882726
91Caffeine metabolism_Homo sapiens_hsa002320.24772354
92GnRH signaling pathway_Homo sapiens_hsa049120.24173400
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.24028848
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.23885522
95Chemical carcinogenesis_Homo sapiens_hsa052040.23339953
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.22927988
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22891502
98Vitamin digestion and absorption_Homo sapiens_hsa049770.22226200
99Viral carcinogenesis_Homo sapiens_hsa052030.21894172
100Sphingolipid metabolism_Homo sapiens_hsa006000.21723466

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »