HLA-DOB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)6.35545908
2immunoglobulin mediated immune response (GO:0016064)6.07669206
3antigen processing and presentation of endogenous antigen (GO:0019883)6.04391764
4regulation of B cell receptor signaling pathway (GO:0050855)5.94841011
5positive regulation of gamma-delta T cell activation (GO:0046645)5.87228039
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.70919612
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.47775707
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.38109881
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.24041376
10negative regulation of cell killing (GO:0031342)5.24041376
11positive thymic T cell selection (GO:0045059)5.16467006
12B cell mediated immunity (GO:0019724)4.87620397
13detection of bacterium (GO:0016045)4.61556685
14* regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.58084953
15interferon-gamma-mediated signaling pathway (GO:0060333)4.56393397
16production of molecular mediator involved in inflammatory response (GO:0002532)4.55056687
17detection of other organism (GO:0098543)4.43983945
18defense response to protozoan (GO:0042832)4.36500589
19positive regulation by symbiont of host defense response (GO:0052509)4.32391254
20modulation by symbiont of host defense response (GO:0052031)4.32391254
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.32391254
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.32391254
23positive regulation by organism of defense response of other organism involved in symbiotic interact4.32391254
24modulation by symbiont of host immune response (GO:0052553)4.32391254
25regulation of B cell differentiation (GO:0045577)4.28542703
26* regulation of antigen processing and presentation (GO:0002577)4.27445055
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.26913856
28regulation of dendritic cell antigen processing and presentation (GO:0002604)4.25965229
29positive regulation of B cell differentiation (GO:0045579)4.23823288
30positive T cell selection (GO:0043368)4.13855164
31regulation of gamma-delta T cell activation (GO:0046643)4.10278030
32thymic T cell selection (GO:0045061)4.05261410
33regulation of interferon-beta biosynthetic process (GO:0045357)4.01158236
34macrophage activation involved in immune response (GO:0002281)3.99840016
35regulation of T-helper 1 cell differentiation (GO:0045625)3.97423597
36leukocyte aggregation (GO:0070486)3.93595938
37antigen receptor-mediated signaling pathway (GO:0050851)3.92531920
38negative thymic T cell selection (GO:0045060)3.90258393
39germinal center formation (GO:0002467)3.87759770
40T cell migration (GO:0072678)3.84927401
41positive regulation of antigen processing and presentation (GO:0002579)3.83277205
42type I interferon signaling pathway (GO:0060337)3.82978852
43cellular response to type I interferon (GO:0071357)3.82978852
44positive regulation of type 2 immune response (GO:0002830)3.81610448
45T cell selection (GO:0045058)3.80344002
46B cell homeostasis (GO:0001782)3.79801229
47response to protozoan (GO:0001562)3.79308692
48response to type I interferon (GO:0034340)3.79116395
49B cell proliferation (GO:0042100)3.74845856
50T cell costimulation (GO:0031295)3.72903691
51negative regulation of T-helper cell differentiation (GO:0045623)3.71390619
52negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.71390619
53negative T cell selection (GO:0043383)3.69942023
54lymphocyte costimulation (GO:0031294)3.67642854
55regulation of gamma-delta T cell differentiation (GO:0045586)3.64947772
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.59225922
57negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.53986245
58detection of external biotic stimulus (GO:0098581)3.52925269
59regulation of T-helper 2 cell differentiation (GO:0045628)3.49745693
60regulation of alpha-beta T cell proliferation (GO:0046640)3.49378067
61NIK/NF-kappaB signaling (GO:0038061)3.49320076
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.43798772
63cellular extravasation (GO:0045123)3.42424721
64cellular response to interferon-gamma (GO:0071346)3.42297478
65positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.39672776
66neutrophil activation involved in immune response (GO:0002283)3.37665851
67positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.35220235
68response to interleukin-15 (GO:0070672)3.31412488
69respiratory burst (GO:0045730)3.31152339
70CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.30709098
71negative regulation of alpha-beta T cell activation (GO:0046636)3.24064583
72positive regulation of interferon-alpha production (GO:0032727)3.23253267
73negative regulation of lymphocyte mediated immunity (GO:0002707)3.22938025
74negative regulation of interleukin-12 production (GO:0032695)3.22096158
75antigen processing and presentation via MHC class Ib (GO:0002475)3.18879632
76positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.18260575
77mast cell activation (GO:0045576)3.15457448
78regulation of T cell tolerance induction (GO:0002664)3.14934887
79T cell receptor signaling pathway (GO:0050852)3.14869678
80immune response-activating cell surface receptor signaling pathway (GO:0002429)3.13650951
81adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.11608368
82cellular response to interleukin-15 (GO:0071350)3.09315807
83myeloid cell activation involved in immune response (GO:0002275)3.08848566
84positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.07069065
85regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.06498856
86positive regulation of B cell proliferation (GO:0030890)3.06013137
87positive regulation of B cell activation (GO:0050871)3.05998533
88lymphocyte homeostasis (GO:0002260)3.04201184
89regulation of germinal center formation (GO:0002634)3.03387105
90regulation of interferon-alpha production (GO:0032647)3.03170912
91response to interferon-gamma (GO:0034341)3.02381699
92regulation of B cell proliferation (GO:0030888)3.02139758
93regulation of type 2 immune response (GO:0002828)3.01860064
94detection of biotic stimulus (GO:0009595)3.01093165
95regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.98838759
96T-helper 1 type immune response (GO:0042088)2.95423763
97adaptive immune response (GO:0002250)2.95367411
98negative regulation of phagocytosis (GO:0050765)2.94305292
99response to peptidoglycan (GO:0032494)2.93196106
100regulation of natural killer cell mediated immunity (GO:0002715)2.92232937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.78600338
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.30939566
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.11530443
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.00112216
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.94926592
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.94588080
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.82897571
8MYC_22102868_ChIP-Seq_BL_Human3.79065958
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.42123121
10E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.23141901
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.22661779
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.87830642
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83324521
14RUNX_20019798_ChIP-Seq_JUKART_Human2.79862280
15VDR_21846776_ChIP-Seq_THP-1_Human2.73939458
16MYB_26560356_Chip-Seq_TH2_Human2.71602878
17MAF_26560356_Chip-Seq_TH1_Human2.50332057
18SPI1_23547873_ChIP-Seq_NB4_Human2.48715833
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43991393
20MYB_26560356_Chip-Seq_TH1_Human2.41382806
21* CIITA_25753668_ChIP-Seq_RAJI_Human2.38575192
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38084023
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.38068610
24VDR_24763502_ChIP-Seq_THP-1_Human2.33978529
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31521063
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.23280489
27UTX_26944678_Chip-Seq_JUKART_Human2.20249026
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19412956
29GATA1_22025678_ChIP-Seq_K562_Human2.13490292
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11673930
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09365030
32SPI1_23127762_ChIP-Seq_K562_Human2.07086097
33MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01163258
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.92686710
35SCL_19346495_ChIP-Seq_HPC-7_Human1.91865283
36MAF_26560356_Chip-Seq_TH2_Human1.88485254
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85959604
38GATA3_27048872_Chip-Seq_THYMUS_Human1.83305120
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75913071
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74360595
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72893249
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.69242865
43TCF7_22412390_ChIP-Seq_EML_Mouse1.67182113
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65878949
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.63336576
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62887316
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54828739
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51879119
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51488787
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45952062
51GATA3_26560356_Chip-Seq_TH2_Human1.45262707
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42804856
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.42322526
54KDM2B_26808549_Chip-Seq_DND41_Human1.39255116
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34833887
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31762775
57VDR_24787735_ChIP-Seq_THP-1_Human1.30943854
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30928075
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28648495
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28589161
61PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24064450
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23583282
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22123522
64BCL6_27268052_Chip-Seq_Bcells_Human1.20857803
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15381606
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.15147100
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15082442
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11951596
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11302497
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10811128
71BCOR_27268052_Chip-Seq_Bcells_Human1.09858988
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07260109
73PU_27001747_Chip-Seq_BMDM_Mouse1.07089727
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05903824
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04975382
76* LXR_22292898_ChIP-Seq_THP-1_Human1.04176374
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03469812
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03440899
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.03238466
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02160546
81P300_27268052_Chip-Seq_Bcells_Human1.00024387
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99527607
83SMAD_19615063_ChIP-ChIP_OVARY_Human0.97447973
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97368442
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95464141
86STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94167614
87SMRT_27268052_Chip-Seq_Bcells_Human0.91601492
88NCOR1_26117541_ChIP-Seq_K562_Human0.89228682
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89126111
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89010618
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.88167281
92RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87751385
93KDM2B_26808549_Chip-Seq_JURKAT_Human0.84599029
94GATA1_19941826_ChIP-Seq_K562_Human0.83352342
95RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79993983
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.79917567
97STAT1_20625510_ChIP-Seq_HELA_Human0.78708741
98SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.73668001
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72923017
100RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71939295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.16216986
2MP0001800_abnormal_humoral_immune4.10001822
3MP0005387_immune_system_phenotype4.09471291
4MP0001790_abnormal_immune_system4.09471291
5MP0000685_abnormal_immune_system3.98590561
6MP0005671_abnormal_response_to3.82778582
7MP0003763_abnormal_thymus_physiology3.61284477
8MP0003436_decreased_susceptibility_to3.39422750
9MP0005000_abnormal_immune_tolerance3.35670711
10MP0002452_abnormal_antigen_presenting3.21550201
11MP0002723_abnormal_immune_serum3.13703391
12MP0003303_peritoneal_inflammation3.10561171
13MP0002420_abnormal_adaptive_immunity2.99868317
14MP0003724_increased_susceptibility_to2.99851218
15MP0001819_abnormal_immune_cell2.94979277
16MP0009785_altered_susceptibility_to2.79399751
17MP0005025_abnormal_response_to2.72692336
18MP0002419_abnormal_innate_immunity2.52687440
19MP0002148_abnormal_hypersensitivity_rea2.51647418
20MP0002398_abnormal_bone_marrow2.49419812
21MP0002138_abnormal_hepatobiliary_system2.39873942
22MP0000716_abnormal_immune_system2.36823915
23MP0010155_abnormal_intestine_physiology2.14677439
24MP0009333_abnormal_splenocyte_physiolog2.11711265
25MP0000689_abnormal_spleen_morphology2.09030284
26MP0002405_respiratory_system_inflammati1.98848143
27MP0002166_altered_tumor_susceptibility1.98699410
28MP0002429_abnormal_blood_cell1.88066240
29MP0002722_abnormal_immune_system1.87662381
30MP0001845_abnormal_inflammatory_respons1.83412442
31MP0005464_abnormal_platelet_physiology1.83355747
32MP0005310_abnormal_salivary_gland1.74773878
33MP0004947_skin_inflammation1.71461102
34MP0001873_stomach_inflammation1.70348007
35MP0003300_gastrointestinal_ulcer1.69477267
36MP0006082_CNS_inflammation1.55996416
37MP0000703_abnormal_thymus_morphology1.55822716
38MP0002396_abnormal_hematopoietic_system1.54606112
39MP0003183_abnormal_peptide_metabolism1.52265562
40MP0003866_abnormal_defecation1.47938859
41MP0002006_tumorigenesis1.45124220
42MP0005451_abnormal_body_composition1.43625543
43MP0001853_heart_inflammation1.40045595
44MP0001533_abnormal_skeleton_physiology1.38375958
45MP0000465_gastrointestinal_hemorrhage1.33007437
46MP0008469_abnormal_protein_level1.32715015
47MP0004381_abnormal_hair_follicle1.18359194
48MP0009764_decreased_sensitivity_to1.13387422
49MP0005075_abnormal_melanosome_morpholog1.12477926
50MP0003191_abnormal_cellular_cholesterol1.06454782
51MP0002933_joint_inflammation1.05087541
52MP0000858_altered_metastatic_potential1.02772333
53MP0005166_decreased_susceptibility_to1.00587163
54MP0000490_abnormal_crypts_of0.96492609
55MP0002132_abnormal_respiratory_system0.96172929
56MP0003045_fibrosis0.95820410
57MP0008260_abnormal_autophagy0.92571983
58MP0001663_abnormal_digestive_system0.91241868
59MP0001348_abnormal_lacrimal_gland0.90820922
60MP0008004_abnormal_stomach_pH0.90766532
61MP0003172_abnormal_lysosome_physiology0.89596920
62MP0001986_abnormal_taste_sensitivity0.88946594
63MP0004510_myositis0.86463548
64MP0001851_eye_inflammation0.86163950
65MP0004883_abnormal_blood_vessel0.84796069
66MP0000249_abnormal_blood_vessel0.79226503
67MP0002019_abnormal_tumor_incidence0.79120320
68MP0009278_abnormal_bone_marrow0.77716156
69MP0004808_abnormal_hematopoietic_stem0.76743785
70MP0005397_hematopoietic_system_phenotyp0.76309518
71MP0001545_abnormal_hematopoietic_system0.76309518
72MP0002998_abnormal_bone_remodeling0.72112687
73MP0002009_preneoplasia0.69909050
74MP0002277_abnormal_respiratory_mucosa0.67581815
75MP0008057_abnormal_DNA_replication0.67327191
76MP0003091_abnormal_cell_migration0.66565428
77MP0003075_altered_response_to0.66247158
78MP0003448_altered_tumor_morphology0.64606818
79MP0009763_increased_sensitivity_to0.62507360
80MP0002136_abnormal_kidney_physiology0.59424967
81MP0008874_decreased_physiological_sensi0.59060830
82MP0003828_pulmonary_edema0.56381171
83MP0005164_abnormal_response_to0.54904607
84MP0002693_abnormal_pancreas_physiology0.52317336
85MP0008995_early_reproductive_senescence0.51403351
86MP0005381_digestive/alimentary_phenotyp0.49933940
87MP0009765_abnormal_xenobiotic_induced0.49143915
88MP0000015_abnormal_ear_pigmentation0.48805853
89MP0003221_abnormal_cardiomyocyte_apopto0.46659500
90MP0005390_skeleton_phenotype0.44912543
91MP0000343_altered_response_to0.44235430
92MP0003786_premature_aging0.43702334
93MP0003795_abnormal_bone_structure0.43421419
94MP0000609_abnormal_liver_physiology0.38800755
95MP0003646_muscle_fatigue0.38049308
96MP0005621_abnormal_cell_physiology0.37177912
97MP0009642_abnormal_blood_homeostasis0.36834756
98MP0000313_abnormal_cell_death0.34427267
99MP0003656_abnormal_erythrocyte_physiolo0.33490605
100MP0005584_abnormal_enzyme/coenzyme_acti0.33135017

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.92820178
2Gastrointestinal stroma tumor (HP:0100723)5.68605961
3Abnormal delayed hypersensitivity skin test (HP:0002963)5.47116851
4Meningitis (HP:0001287)5.41932681
5Panhypogammaglobulinemia (HP:0003139)5.07939485
6Eczematoid dermatitis (HP:0000976)4.87320266
7Mediastinal lymphadenopathy (HP:0100721)4.82984335
8Recurrent bacterial skin infections (HP:0005406)4.73244917
9Cellulitis (HP:0100658)4.63286423
10Vasculitis (HP:0002633)4.53919767
11Colitis (HP:0002583)4.53536761
12Recurrent bronchitis (HP:0002837)4.52746499
13Recurrent abscess formation (HP:0002722)4.45846680
14Recurrent sinusitis (HP:0011108)4.29722383
15Lymphopenia (HP:0001888)4.16917928
16Recurrent fungal infections (HP:0002841)4.11422992
17Recurrent viral infections (HP:0004429)4.10542561
18Inflammation of the large intestine (HP:0002037)4.09061056
19Recurrent cutaneous fungal infections (HP:0011370)4.04161648
20Chronic mucocutaneous candidiasis (HP:0002728)4.04161648
21Obstructive lung disease (HP:0006536)3.98908836
22Chronic obstructive pulmonary disease (HP:0006510)3.98908836
23Gastrointestinal inflammation (HP:0004386)3.98230611
24Abnormality of cells of the lymphoid lineage (HP:0012140)3.90828573
25Encephalitis (HP:0002383)3.86316790
26Chronic sinusitis (HP:0011109)3.81775237
27Abnormality of macrophages (HP:0004311)3.80748207
28Papilloma (HP:0012740)3.77530042
29Verrucae (HP:0200043)3.77530042
30IgM deficiency (HP:0002850)3.65962638
31Recurrent skin infections (HP:0001581)3.65604520
32Stomatitis (HP:0010280)3.61943694
33Emphysema (HP:0002097)3.49009468
34Pulmonary infiltrates (HP:0002113)3.47361842
35Gastrointestinal infarctions (HP:0005244)3.45126345
36Spontaneous hematomas (HP:0007420)3.41342849
37Myositis (HP:0100614)3.35099274
38Increased IgE level (HP:0003212)3.32222103
39Recurrent gram-negative bacterial infections (HP:0005420)3.30252061
40Restrictive lung disease (HP:0002091)3.27376723
41Recurrent pneumonia (HP:0006532)3.24099100
42Elevated erythrocyte sedimentation rate (HP:0003565)3.22342785
43Abnormality of T cells (HP:0002843)3.20810422
44Urticaria (HP:0001025)3.19902263
45Osteomyelitis (HP:0002754)3.16352240
46Recurrent lower respiratory tract infections (HP:0002783)3.15940279
47Optic neuritis (HP:0100653)3.15250086
48Retrobulbar optic neuritis (HP:0100654)3.15250086
49Abnormality of T cell physiology (HP:0011840)3.12569037
50Abnormality of the prostate (HP:0008775)3.08929431
51Chest pain (HP:0100749)3.06527328
52Orchitis (HP:0100796)3.03057018
53Chronic otitis media (HP:0000389)3.00453008
54IgG deficiency (HP:0004315)3.00056842
55Abnormality of T cell number (HP:0011839)2.99006537
56Viral hepatitis (HP:0006562)2.97037595
57T lymphocytopenia (HP:0005403)2.96157794
58Sepsis (HP:0100806)2.91304653
59Hemoptysis (HP:0002105)2.90588011
60Increased IgM level (HP:0003496)2.77088676
61Pustule (HP:0200039)2.72882966
62Skin rash (HP:0000988)2.72319478
63Abnormality of B cell number (HP:0010975)2.65342251
64Bronchitis (HP:0012387)2.59266660
65Lymphoma (HP:0002665)2.58319429
66Abnormality of the pleura (HP:0002103)2.58135720
67Keratoconjunctivitis sicca (HP:0001097)2.49041943
68Recurrent otitis media (HP:0000403)2.48755507
69Chronic diarrhea (HP:0002028)2.48436418
70Granulocytopenia (HP:0001913)2.45845752
71Gingivitis (HP:0000230)2.45355045
72Prolonged bleeding time (HP:0003010)2.43969422
73Epistaxis (HP:0000421)2.43587999
74B lymphocytopenia (HP:0010976)2.41594010
75Autoimmune hemolytic anemia (HP:0001890)2.39555155
76Skin ulcer (HP:0200042)2.39210428
77IgA deficiency (HP:0002720)2.39120800
78Pulmonary embolism (HP:0002204)2.38552740
79Hypergammaglobulinemia (HP:0010702)2.35914039
80Keratoconjunctivitis (HP:0001096)2.28173468
81Hypochromic anemia (HP:0001931)2.22663175
82Gangrene (HP:0100758)2.15835482
83Eosinophilia (HP:0001880)2.14897488
84Abnormality of the peritoneum (HP:0002585)2.12431168
85Leukocytosis (HP:0001974)2.12014476
86Petechiae (HP:0000967)2.11991606
87Arthralgia (HP:0002829)2.11864642
88Pulmonary fibrosis (HP:0002206)2.10229950
89Gingival bleeding (HP:0000225)2.08572694
90Fatigue (HP:0012378)2.08165270
91Hypertensive crisis (HP:0100735)2.00900121
92Leukopenia (HP:0001882)2.00137059
93Nasal polyposis (HP:0100582)1.93527134
94Abnormality of male internal genitalia (HP:0000022)1.93194403
95Neutropenia (HP:0001875)1.88603612
96Arterial thrombosis (HP:0004420)1.88371715
97Purpura (HP:0000979)1.85331356
98Glomerulopathy (HP:0100820)1.82322665
99Premature loss of primary teeth (HP:0006323)1.82206234
100Anorexia (HP:0002039)1.78421195

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.06090810
2RIPK44.98057718
3ERN13.78019767
4BLK3.56435859
5IRAK42.73857637
6BTK2.47683947
7SYK2.47590886
8TYK22.38285175
9TXK2.34751523
10PRPF4B2.26304990
11MAP3K132.15547955
12MAP3K142.09225078
13TNK22.05127986
14IKBKE2.02457690
15BMPR22.01008159
16JAK31.95903900
17CSF1R1.89587329
18LYN1.73776211
19MAP3K101.73632172
20CSK1.71437435
21SIK31.65934392
22GRK61.62941438
23MARK31.56082078
24HCK1.53719106
25KIT1.53020411
26FES1.50321614
27TBK11.50159828
28MAP2K21.48803877
29TAOK31.41905474
30TEC1.38495554
31ZAP701.38461964
32SIK21.36972723
33IKBKB1.36196465
34STK101.30450145
35ITK1.30298268
36JAK11.28993147
37LCK1.21437489
38NEK91.18455189
39LRRK21.18247324
40NME21.11401100
41MAP2K31.04444879
42PASK1.03070514
43PRKCQ0.97835350
44MAPK120.92008626
45FGR0.91211319
46JAK20.87078544
47CDC42BPA0.81208264
48SMG10.77610428
49IRAK20.76641844
50MAP3K10.74859374
51NLK0.70361867
52PIM10.68243668
53PDK10.66190117
54MST40.66088828
55TESK20.65825140
56MATK0.64442649
57MAP2K10.62397763
58MAP3K110.61814005
59MAPK70.59875717
60FYN0.59010685
61YES10.57831201
62MAPK110.56836502
63SIK10.56605385
64CDK40.56529117
65PIK3CG0.55903504
66MARK20.53974942
67MAP3K30.53221095
68TAOK10.50548267
69FGFR30.49280536
70ABL10.49125720
71HIPK20.48512798
72IRAK10.46320460
73CHUK0.45134483
74MAP3K80.44957125
75FGFR40.44697389
76KSR20.43628371
77PRKD20.41992666
78STK110.41898721
79TAOK20.41807023
80TRIB30.39793877
81MAPKAPK20.39062652
82PDPK10.38067020
83CDK190.38002371
84STK160.34124433
85CAMKK10.33273110
86MAP3K70.32113296
87MELK0.28786328
88MAPK40.28530540
89MAPK30.26289144
90RPS6KA60.25340974
91RPS6KC10.24950215
92RPS6KL10.24950215
93DYRK1A0.24555325
94EIF2AK30.24102494
95DYRK1B0.23801262
96PRKCD0.23703349
97EPHB10.22056266
98INSR0.21866658
99MAP3K20.21855379
100STK240.20962974

Predicted pathways (KEGG)

RankGene SetZ-score
1* Allograft rejection_Homo sapiens_hsa053304.57955851
2* Autoimmune thyroid disease_Homo sapiens_hsa053204.33310703
3* Asthma_Homo sapiens_hsa053104.27327511
4* Graft-versus-host disease_Homo sapiens_hsa053324.25061760
5* Intestinal immune network for IgA production_Homo sapiens_hsa046723.86582399
6* Type I diabetes mellitus_Homo sapiens_hsa049403.54675877
7Primary immunodeficiency_Homo sapiens_hsa053403.50588359
8* Staphylococcus aureus infection_Homo sapiens_hsa051502.99516083
9* Leishmaniasis_Homo sapiens_hsa051402.98690948
10B cell receptor signaling pathway_Homo sapiens_hsa046622.90122890
11* Viral myocarditis_Homo sapiens_hsa054162.84629623
12* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.82740777
13* Antigen processing and presentation_Homo sapiens_hsa046122.75511730
14Hematopoietic cell lineage_Homo sapiens_hsa046401.98824764
15* Toxoplasmosis_Homo sapiens_hsa051451.88730435
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.78693347
17* Tuberculosis_Homo sapiens_hsa051521.77739620
18Osteoclast differentiation_Homo sapiens_hsa043801.74958586
19* Herpes simplex infection_Homo sapiens_hsa051681.69093980
20* Influenza A_Homo sapiens_hsa051641.63558582
21* Rheumatoid arthritis_Homo sapiens_hsa053231.54380622
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53152792
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38797912
24T cell receptor signaling pathway_Homo sapiens_hsa046601.28228472
25Measles_Homo sapiens_hsa051621.27611573
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22380227
27* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14756529
28* Systemic lupus erythematosus_Homo sapiens_hsa053221.13384755
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04337404
30* Phagosome_Homo sapiens_hsa041451.01679290
31Chemokine signaling pathway_Homo sapiens_hsa040621.01670553
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01101821
33Epstein-Barr virus infection_Homo sapiens_hsa051691.00203845
34Jak-STAT signaling pathway_Homo sapiens_hsa046300.97534726
35Acute myeloid leukemia_Homo sapiens_hsa052210.95551901
36NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92826472
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89357966
38Hepatitis B_Homo sapiens_hsa051610.84333356
39TNF signaling pathway_Homo sapiens_hsa046680.81064163
40* HTLV-I infection_Homo sapiens_hsa051660.79200444
41Non-small cell lung cancer_Homo sapiens_hsa052230.78979187
42Malaria_Homo sapiens_hsa051440.71080206
43Apoptosis_Homo sapiens_hsa042100.70282276
44Hepatitis C_Homo sapiens_hsa051600.65574245
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64993570
46Legionellosis_Homo sapiens_hsa051340.64286403
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.64209170
48African trypanosomiasis_Homo sapiens_hsa051430.63536824
49Other glycan degradation_Homo sapiens_hsa005110.59618271
50Pancreatic cancer_Homo sapiens_hsa052120.59484398
51Platelet activation_Homo sapiens_hsa046110.58053727
52Pertussis_Homo sapiens_hsa051330.57105940
53VEGF signaling pathway_Homo sapiens_hsa043700.55707798
54Viral carcinogenesis_Homo sapiens_hsa052030.54535577
55Shigellosis_Homo sapiens_hsa051310.51486002
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48034367
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47628266
58Ribosome_Homo sapiens_hsa030100.46195679
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.45231042
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45018514
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42171662
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40167307
63Prolactin signaling pathway_Homo sapiens_hsa049170.38396103
64Chronic myeloid leukemia_Homo sapiens_hsa052200.38273071
65Colorectal cancer_Homo sapiens_hsa052100.36222736
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36072463
67Choline metabolism in cancer_Homo sapiens_hsa052310.32399762
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.32105680
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30203971
70Renal cell carcinoma_Homo sapiens_hsa052110.29289572
71Endometrial cancer_Homo sapiens_hsa052130.29158431
72Prostate cancer_Homo sapiens_hsa052150.27220024
73mTOR signaling pathway_Homo sapiens_hsa041500.26688015
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.25187069
75Salmonella infection_Homo sapiens_hsa051320.23552689
76Endocytosis_Homo sapiens_hsa041440.22866526
77Notch signaling pathway_Homo sapiens_hsa043300.21470349
78Small cell lung cancer_Homo sapiens_hsa052220.20671568
79FoxO signaling pathway_Homo sapiens_hsa040680.20651399
80MAPK signaling pathway_Homo sapiens_hsa040100.20145395
81Type II diabetes mellitus_Homo sapiens_hsa049300.18389438
82Dorso-ventral axis formation_Homo sapiens_hsa043200.18098486
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18068375
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16431176
85HIF-1 signaling pathway_Homo sapiens_hsa040660.16106346
86Inositol phosphate metabolism_Homo sapiens_hsa005620.15495714
87Regulation of autophagy_Homo sapiens_hsa041400.14094314
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13415109
89GnRH signaling pathway_Homo sapiens_hsa049120.12838711
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12780645
91Insulin resistance_Homo sapiens_hsa049310.11382915
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.07691737
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.06743204
94ErbB signaling pathway_Homo sapiens_hsa040120.06202958
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.06006585
96Lysosome_Homo sapiens_hsa041420.04391147
97p53 signaling pathway_Homo sapiens_hsa041150.04356940
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.03932208
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.03500443
100Ras signaling pathway_Homo sapiens_hsa040140.03163980

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