HKR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukocyte aggregation (GO:0070486)9.26019230
2positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)8.70968448
3glycoprotein catabolic process (GO:0006516)8.51491080
4rRNA transcription (GO:0009303)7.35918632
5positive regulation of signal transduction by p53 class mediator (GO:1901798)6.85628093
6macroautophagy (GO:0016236)6.26990322
7SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)5.77736757
8positive regulation of vascular permeability (GO:0043117)5.25221136
9reciprocal DNA recombination (GO:0035825)5.24243704
10reciprocal meiotic recombination (GO:0007131)5.24243704
11meiotic chromosome segregation (GO:0045132)5.17844427
12induction of positive chemotaxis (GO:0050930)5.12567672
13myelin assembly (GO:0032288)4.85177308
14positive regulation of defense response to virus by host (GO:0002230)4.65697650
15resolution of meiotic recombination intermediates (GO:0000712)4.48709429
16spinal cord development (GO:0021510)4.35727732
17forebrain morphogenesis (GO:0048853)4.28404054
18nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)4.28184928
19piRNA metabolic process (GO:0034587)4.22941022
20erythrocyte maturation (GO:0043249)4.18047676
21chaperone-mediated protein transport (GO:0072321)4.17212697
22lateral ventricle development (GO:0021670)4.12378810
23hair cell differentiation (GO:0035315)4.12168779
24DNA deamination (GO:0045006)4.11412004
25epithelial cilium movement (GO:0003351)3.96404540
26cilium or flagellum-dependent cell motility (GO:0001539)3.94106156
27regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)3.92835601
28astrocyte differentiation (GO:0048708)3.79742632
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.67078278
30male meiosis I (GO:0007141)3.63545137
31iron-sulfur cluster assembly (GO:0016226)3.61973760
32metallo-sulfur cluster assembly (GO:0031163)3.61973760
33hematopoietic stem cell differentiation (GO:0060218)3.52610840
34DNA methylation involved in gamete generation (GO:0043046)3.48989074
35cilium movement (GO:0003341)3.41454943
36I-kappaB kinase/NF-kappaB signaling (GO:0007249)3.39787006
37protein targeting to lysosome (GO:0006622)3.39194455
38establishment of protein localization to vacuole (GO:0072666)3.39194455
39protein targeting to vacuole (GO:0006623)3.39194455
40heart morphogenesis (GO:0003007)3.34156116
41behavioral response to nicotine (GO:0035095)3.33840936
42maintenance of protein location in nucleus (GO:0051457)3.31865973
43gamma-aminobutyric acid transport (GO:0015812)3.30517414
44peroxisome organization (GO:0007031)3.28126213
45cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)3.25796008
46UV protection (GO:0009650)3.22999197
47synapsis (GO:0007129)3.10882988
48regulation of synapse maturation (GO:0090128)3.08831822
49peroxisome fission (GO:0016559)3.05842600
50response to pheromone (GO:0019236)3.05780951
51positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.94780938
52synaptonemal complex assembly (GO:0007130)2.94100133
53transcription from mitochondrial promoter (GO:0006390)2.86712594
54regulation of action potential (GO:0098900)2.86589234
55detection of light stimulus involved in visual perception (GO:0050908)2.82423937
56detection of light stimulus involved in sensory perception (GO:0050962)2.82423937
57positive regulation of monocyte chemotaxis (GO:0090026)2.82200767
58energy homeostasis (GO:0097009)2.82199930
59axonemal dynein complex assembly (GO:0070286)2.78573483
60protein polyglutamylation (GO:0018095)2.78247479
61positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.78067660
62positive regulation of positive chemotaxis (GO:0050927)2.77665092
63regulation of positive chemotaxis (GO:0050926)2.72508890
64regulation of cilium movement (GO:0003352)2.71564420
65pseudouridine synthesis (GO:0001522)2.71059364
66synaptonemal complex organization (GO:0070193)2.69786560
67glomerulus development (GO:0032835)2.69157244
68chromosome organization involved in meiosis (GO:0070192)2.69092744
69negative regulation of telomere maintenance (GO:0032205)2.67757919
70axoneme assembly (GO:0035082)2.67535658
71somite rostral/caudal axis specification (GO:0032525)2.66699539
72cellular ketone body metabolic process (GO:0046950)2.66671271
73histone H4-K12 acetylation (GO:0043983)2.66047116
74negative regulation of mast cell activation (GO:0033004)2.65441306
75meiosis I (GO:0007127)2.64434144
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.62404808
77mitochondrial respiratory chain complex I assembly (GO:0032981)2.62404808
78NADH dehydrogenase complex assembly (GO:0010257)2.62404808
79regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.60439665
80regulation of mitotic spindle checkpoint (GO:1903504)2.60439665
81male meiosis (GO:0007140)2.58600625
82proline transport (GO:0015824)2.58527260
83myoblast migration (GO:0051451)2.57647186
84protein targeting to peroxisome (GO:0006625)2.55313533
85establishment of protein localization to peroxisome (GO:0072663)2.55313533
86protein localization to peroxisome (GO:0072662)2.55313533
87protein localization to vacuole (GO:0072665)2.55206954
88protein localization to lysosome (GO:0061462)2.55206954
89protein complex biogenesis (GO:0070271)2.54123096
90transcription elongation from RNA polymerase I promoter (GO:0006362)2.52603418
91JNK cascade (GO:0007254)2.49266313
92neuronal action potential propagation (GO:0019227)2.48442365
93regulation of defense response to virus by host (GO:0050691)2.48092685
94cysteine metabolic process (GO:0006534)2.47611130
95early endosome to late endosome transport (GO:0045022)2.45884420
96astrocyte development (GO:0014002)2.45727939
97transcription from RNA polymerase I promoter (GO:0006360)2.45302080
98RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.45112735
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.45112735
100activation of MAPKKK activity (GO:0000185)11.7858274

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.18048444
2EZH2_22144423_ChIP-Seq_EOC_Human3.44140333
3ZNF274_21170338_ChIP-Seq_K562_Hela3.38481783
4GBX2_23144817_ChIP-Seq_PC3_Human3.33389340
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.14018955
6VDR_22108803_ChIP-Seq_LS180_Human2.74089366
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.71399471
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17171842
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10234702
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.07062447
11NOTCH1_21737748_ChIP-Seq_TLL_Human1.95123721
12FUS_26573619_Chip-Seq_HEK293_Human1.91596894
13TP53_22573176_ChIP-Seq_HFKS_Human1.88042015
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87899940
15TAF15_26573619_Chip-Seq_HEK293_Human1.85689153
16ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.83628630
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.82551793
18DROSHA_22980978_ChIP-Seq_HELA_Human1.81399391
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.80263577
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79324005
21IGF1R_20145208_ChIP-Seq_DFB_Human1.79211727
22EWS_26573619_Chip-Seq_HEK293_Human1.73157827
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62441760
24AR_20517297_ChIP-Seq_VCAP_Human1.60891500
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59925885
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55936494
27FOXA1_27270436_Chip-Seq_PROSTATE_Human1.53504124
28FOXA1_25329375_ChIP-Seq_VCAP_Human1.53504124
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.53171114
30ER_23166858_ChIP-Seq_MCF-7_Human1.52111494
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49538064
32GATA3_21878914_ChIP-Seq_MCF-7_Human1.45966619
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45885597
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.45531452
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.45057944
36FOXA1_21572438_ChIP-Seq_LNCaP_Human1.44874669
37P300_19829295_ChIP-Seq_ESCs_Human1.44144618
38AR_25329375_ChIP-Seq_VCAP_Human1.42724060
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42670535
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41169231
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40832470
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.37486967
43REST_21632747_ChIP-Seq_MESCs_Mouse1.36415242
44STAT1_20625510_ChIP-Seq_HELA_Human1.36026379
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34602595
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32428037
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.31447954
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30534432
49NCOR_22424771_ChIP-Seq_293T_Human1.30120513
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28909522
51STAT3_23295773_ChIP-Seq_U87_Human1.28874965
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26546249
53CBP_20019798_ChIP-Seq_JUKART_Human1.26546249
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26273878
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25840956
56P53_22127205_ChIP-Seq_FIBROBLAST_Human1.24987560
57RUNX2_22187159_ChIP-Seq_PCA_Human1.24443709
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.24203417
59RNF2_27304074_Chip-Seq_NSC_Mouse1.23565062
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22736541
61VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21856332
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21326107
63SMAD4_21799915_ChIP-Seq_A2780_Human1.20719365
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20401773
65TP53_16413492_ChIP-PET_HCT116_Human1.20305168
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16805213
67ERA_21632823_ChIP-Seq_H3396_Human1.15699889
68* TCF4_23295773_ChIP-Seq_U87_Human1.14568631
69MYC_19829295_ChIP-Seq_ESCs_Human1.14440018
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13838286
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.13058877
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.12759603
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12462018
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.10401777
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.10325273
76NANOG_19829295_ChIP-Seq_ESCs_Human1.09973757
77SOX2_19829295_ChIP-Seq_ESCs_Human1.09973757
78TAF2_19829295_ChIP-Seq_ESCs_Human1.09260728
79* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05726006
80SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05225234
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04942023
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03214385
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03119121
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03119121
85AR_21572438_ChIP-Seq_LNCaP_Human1.03114942
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02526810
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.02170899
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.00902289
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00772254
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00570748
91CIITA_25753668_ChIP-Seq_RAJI_Human1.00059686
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97117439
93IRF1_19129219_ChIP-ChIP_H3396_Human0.96699940
94MYC_18940864_ChIP-ChIP_HL60_Human0.96130867
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95920711
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95802031
97CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93770063
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.93333959
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.92984901
100E2F1_20622854_ChIP-Seq_HELA_Human0.92622907

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology8.92854356
2MP0000750_abnormal_muscle_regeneration3.99079276
3MP0000013_abnormal_adipose_tissue3.76642387
4MP0009384_cardiac_valve_regurgitation3.38360414
5MP0002938_white_spotting3.12675619
6MP0002638_abnormal_pupillary_reflex3.11497644
7MP0003786_premature_aging2.80015668
8MP0005551_abnormal_eye_electrophysiolog2.65131900
9MP0002102_abnormal_ear_morphology2.59665708
10MP0003385_abnormal_body_wall1.76773994
11MP0008058_abnormal_DNA_repair1.73645013
12MP0008877_abnormal_DNA_methylation1.73117305
13MP0004147_increased_porphyrin_level1.70332943
14MP0002067_abnormal_sensory_capabilities1.64557066
15MP0002277_abnormal_respiratory_mucosa1.62238965
16MP0000762_abnormal_tongue_morphology1.58483192
17MP0003880_abnormal_central_pattern1.50523876
18MP0009046_muscle_twitch1.48320545
19MP0006292_abnormal_olfactory_placode1.44863244
20MP0010307_abnormal_tumor_latency1.42512737
21MP0003137_abnormal_impulse_conducting1.40896533
22MP0001968_abnormal_touch/_nociception1.40607557
23MP0003787_abnormal_imprinting1.37299091
24MP0003195_calcinosis1.35616034
25MP0004130_abnormal_muscle_cell1.32421616
26MP0003011_delayed_dark_adaptation1.32005481
27MP0001986_abnormal_taste_sensitivity1.30551551
28MP0000003_abnormal_adipose_tissue1.28788348
29MP0000631_abnormal_neuroendocrine_gland1.26053025
30MP0009745_abnormal_behavioral_response1.23109179
31MP0002736_abnormal_nociception_after1.22830937
32MP0005645_abnormal_hypothalamus_physiol1.22687978
33MP0002272_abnormal_nervous_system1.21908005
34MP0002572_abnormal_emotion/affect_behav1.20751729
35MP0002837_dystrophic_cardiac_calcinosis1.20558013
36MP0002735_abnormal_chemical_nociception1.18326770
37MP0001486_abnormal_startle_reflex1.16426235
38MP0004142_abnormal_muscle_tone1.14127251
39MP0001502_abnormal_circadian_rhythm1.12992864
40MP0002160_abnormal_reproductive_system1.12420485
41MP0003136_yellow_coat_color1.12284977
42MP0002653_abnormal_ependyma_morphology1.11785173
43MP0002269_muscular_atrophy1.11263115
44MP0002177_abnormal_outer_ear1.10569569
45MP0004133_heterotaxia1.10044693
46MP0003115_abnormal_respiratory_system1.08718189
47MP0003698_abnormal_male_reproductive1.07646916
48MP0000858_altered_metastatic_potential1.04823501
49MP0005671_abnormal_response_to1.04017255
50MP0008775_abnormal_heart_ventricle1.02438471
51MP0006276_abnormal_autonomic_nervous1.02398509
52MP0002163_abnormal_gland_morphology1.01515797
53MP0001485_abnormal_pinna_reflex0.99453233
54MP0008872_abnormal_physiological_respon0.99294415
55MP0001984_abnormal_olfaction0.98439368
56MP0003646_muscle_fatigue0.97574322
57MP0008770_decreased_survivor_rate0.97227587
58MP0005646_abnormal_pituitary_gland0.94194509
59MP0003121_genomic_imprinting0.94118116
60MP0005195_abnormal_posterior_eye0.94030756
61MP0002064_seizures0.93527721
62MP0005584_abnormal_enzyme/coenzyme_acti0.92717046
63MP0008995_early_reproductive_senescence0.92672638
64MP0002063_abnormal_learning/memory/cond0.92138018
65MP0005379_endocrine/exocrine_gland_phen0.91303236
66MP0004924_abnormal_behavior0.89402715
67MP0005386_behavior/neurological_phenoty0.89402715
68MP0003890_abnormal_embryonic-extraembry0.89354590
69MP0004043_abnormal_pH_regulation0.88548945
70MP0006072_abnormal_retinal_apoptosis0.87729688
71MP0003755_abnormal_palate_morphology0.87544383
72MP0009379_abnormal_foot_pigmentation0.86577981
73MP0004215_abnormal_myocardial_fiber0.85485974
74MP0005377_hearing/vestibular/ear_phenot0.84932585
75MP0003878_abnormal_ear_physiology0.84932585
76MP0005389_reproductive_system_phenotype0.83092434
77MP0005410_abnormal_fertilization0.83022019
78MP0002752_abnormal_somatic_nervous0.80019191
79MP0003635_abnormal_synaptic_transmissio0.79729039
80MP0002876_abnormal_thyroid_physiology0.79493705
81MP0005253_abnormal_eye_physiology0.78304911
82MP0004742_abnormal_vestibular_system0.78277689
83MP0002882_abnormal_neuron_morphology0.77217701
84MP0003119_abnormal_digestive_system0.76585820
85MP0002751_abnormal_autonomic_nervous0.76055341
86MP0002210_abnormal_sex_determination0.76002912
87MP0004947_skin_inflammation0.75844607
88MP0001929_abnormal_gametogenesis0.75809560
89MP0004885_abnormal_endolymph0.75422382
90MP0002106_abnormal_muscle_physiology0.75072761
91MP0008789_abnormal_olfactory_epithelium0.74745614
92MP0005083_abnormal_biliary_tract0.73756431
93MP0000566_synostosis0.73236803
94MP0000427_abnormal_hair_cycle0.71917035
95MP0001145_abnormal_male_reproductive0.71676031
96MP0002557_abnormal_social/conspecific_i0.70802526
97MP0002734_abnormal_mechanical_nocicepti0.70403102
98MP0000653_abnormal_sex_gland0.70302592
99MP0002234_abnormal_pharynx_morphology0.70039188
100MP0005423_abnormal_somatic_nervous0.69046081

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)9.79554121
2Retinal dysplasia (HP:0007973)8.55596212
3Hypoplasia of the pons (HP:0012110)8.37222117
4Abnormality of the pons (HP:0007361)7.67001720
5Decreased electroretinogram (ERG) amplitude (HP:0000654)6.60817543
6Fatigue (HP:0012378)6.53863820
7Buphthalmos (HP:0000557)6.08245283
8Aplasia/Hypoplasia affecting the retina (HP:0008061)5.67961008
9Abolished electroretinogram (ERG) (HP:0000550)5.53949475
10Difficulty climbing stairs (HP:0003551)5.52044850
11Severe muscular hypotonia (HP:0006829)4.20912258
12Lissencephaly (HP:0001339)3.87013408
13Megalocornea (HP:0000485)3.82540241
14Congenital glaucoma (HP:0001087)3.36590814
15Generalized hypotonia (HP:0001290)3.31234087
16Entropion (HP:0000621)3.18138494
17Abnormality of DNA repair (HP:0003254)3.17490549
18Molar tooth sign on MRI (HP:0002419)3.09954408
19Abnormality of midbrain morphology (HP:0002418)3.09954408
20Pachygyria (HP:0001302)3.09801880
21Nephronophthisis (HP:0000090)3.01052124
22Intellectual disability, profound (HP:0002187)2.98241818
23Aplasia/Hypoplasia of the brainstem (HP:0007362)2.98165617
24Hypoplasia of the brainstem (HP:0002365)2.98165617
25Abnormality of the vitreous humor (HP:0004327)2.86695663
26Meningocele (HP:0002435)2.86694386
27Non-midline cleft lip (HP:0100335)2.81092197
28Severe global developmental delay (HP:0011344)2.76885624
29Poikiloderma (HP:0001029)2.71182258
30Pancreatic cysts (HP:0001737)2.58864269
31IgG deficiency (HP:0004315)2.57082182
32Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.52650234
33Medial flaring of the eyebrow (HP:0010747)2.51186880
34Chronic hepatic failure (HP:0100626)2.49038210
35Abnormality of the renal medulla (HP:0100957)2.45809658
36Mesangial abnormality (HP:0001966)2.42397959
37Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.40136429
38Abnormality of vision evoked potentials (HP:0000649)2.39432142
39Gowers sign (HP:0003391)2.38965912
40True hermaphroditism (HP:0010459)2.37623364
41Generalized muscle weakness (HP:0003324)2.32752460
42Pancreatic fibrosis (HP:0100732)2.31181845
43Polymicrogyria (HP:0002126)2.29708283
44Muscular dystrophy (HP:0003560)2.11821299
45Cerebellar dysplasia (HP:0007033)10.8899073
46Retinal atrophy (HP:0001105)10.0954979
47Abnormality of the metopic suture (HP:0005556)1.96968164
48Prominent metopic ridge (HP:0005487)1.95926975
49Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95394115
50Tubular atrophy (HP:0000092)1.94485128
51Abnormal drinking behavior (HP:0030082)1.94174306
52Polydipsia (HP:0001959)1.94174306
53Fragile nails (HP:0001808)1.91724435
54Absent/shortened dynein arms (HP:0200106)1.91469552
55Dynein arm defect of respiratory motile cilia (HP:0012255)1.91469552
56Decreased subcutaneous fat (HP:0001002)1.88790549
57Holoprosencephaly (HP:0001360)1.88519013
58Abnormal albumin level (HP:0012116)1.87876398
59Hypoalbuminemia (HP:0003073)1.87876398
60Submucous cleft hard palate (HP:0000176)1.86922048
61Cystic liver disease (HP:0006706)1.81691053
62Brittle hair (HP:0002299)1.81673406
63Abnormality of the renal cortex (HP:0011035)1.81115911
64Dandy-Walker malformation (HP:0001305)1.81042201
65Increased IgM level (HP:0003496)1.79132643
66Colon cancer (HP:0003003)1.77149647
67Cone-rod dystrophy (HP:0000548)1.75987601
68Rectal prolapse (HP:0002035)1.74074117
69Abnormal respiratory motile cilium morphology (HP:0005938)1.71624977
70Abnormal respiratory epithelium morphology (HP:0012253)1.71624977
71Erythroderma (HP:0001019)1.70329341
72Congenital hepatic fibrosis (HP:0002612)1.67625730
73Papilledema (HP:0001085)1.66928558
74Sclerocornea (HP:0000647)1.65919085
75Pallor (HP:0000980)1.64658173
76Conical tooth (HP:0000698)1.58561626
77Intellectual disability, severe (HP:0010864)1.58178261
78Occipital encephalocele (HP:0002085)1.58099086
79Supranuclear gaze palsy (HP:0000605)1.56712825
80Keratitis (HP:0000491)1.56218753
81Abdominal situs inversus (HP:0003363)1.54686653
82Abnormality of abdominal situs (HP:0011620)1.54686653
83Eosinophilia (HP:0001880)1.54468454
84Nephropathy (HP:0000112)1.53922321
85Cerebral hypomyelination (HP:0006808)1.51318239
86Congenital stationary night blindness (HP:0007642)1.51003099
87Iris coloboma (HP:0000612)1.50578385
88Postaxial foot polydactyly (HP:0001830)1.49045690
89Polyuria (HP:0000103)1.47071774
90Ectropion (HP:0000656)1.45306518
91Sacral dimple (HP:0000960)1.44995615
92Atonic seizures (HP:0010819)1.39201208
93Optic nerve coloboma (HP:0000588)1.37170475
94Everted lower lip vermilion (HP:0000232)1.36377355
95Scrotal hypoplasia (HP:0000046)1.34861886
96Macular degeneration (HP:0000608)1.34105797
97Abnormal ciliary motility (HP:0012262)1.33087903
98Abnormality of subcutaneous fat tissue (HP:0001001)1.32668035
99Abnormality of eosinophils (HP:0001879)1.31982965
100Omphalocele (HP:0001539)1.31940096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK37.72417929
2STK107.14385916
3FRK3.44186539
4STK112.96716853
5PTK2B2.84771258
6PIM12.64481018
7TXK2.54654894
8NLK2.35287644
9LMTK21.95464046
10MAP4K21.90666025
11WNK31.77064961
12INSRR1.68882840
13BMPR1B1.54529756
14MAP3K41.49801738
15CAMKK21.47162364
16EPHA31.46407533
17ADRBK21.41987233
18GRK11.31409997
19CASK1.26586268
20CDK191.22180516
21PRKCH1.21754672
22BRSK21.19396307
23ZAK1.13876085
24TLK11.13710657
25ACVR1B1.13370744
26MAPK131.07841358
27MAPK151.00450635
28MARK10.99825145
29PINK10.93137401
30CSNK1G10.92180584
31MAP4K10.89536333
32NUAK10.89197777
33WNK40.88316071
34CSNK1G30.87316244
35MAP2K70.83951840
36PIK3CA0.83731252
37DYRK20.81592992
38EPHA40.79438840
39CSNK1G20.79349358
40CSNK1A1L0.75886553
41DYRK1A0.73593034
42DAPK20.70152652
43PRKCE0.68918957
44OBSCN0.68396966
45PKN10.66577188
46MAP2K20.66326271
47OXSR10.64864375
48PAK30.64846057
49FGFR20.63715933
50MAP3K70.63623118
51PNCK0.62817158
52PRKCG0.61527726
53CSNK1D0.57556160
54TIE10.51824024
55CAMK10.51523372
56NTRK20.50959515
57RPS6KA50.49236666
58TAOK30.47807783
59MUSK0.46179203
60BCKDK0.45305314
61CLK10.45274003
62GSK3A0.44924452
63ADRBK10.44801877
64SRPK10.43412241
65MAP2K60.43366326
66PHKG20.43209579
67PHKG10.43209579
68NEK20.42200567
69TNIK0.41087648
70PLK40.41000560
71IRAK10.40965802
72IKBKB0.40777683
73TGFBR10.40733901
74CSNK1A10.37024388
75CAMK1D0.36764626
76CAMKK10.36711365
77AKT30.36483779
78YES10.35274477
79CAMK1G0.33310807
80CAMK2A0.32597435
81WNK10.32306877
82NTRK30.31736389
83PRKCQ0.31413013
84TNK20.30287716
85UHMK10.29351747
86PRKD20.28759051
87STK390.28717519
88CHUK0.28277443
89PRKACA0.27879665
90KIT0.27396333
91VRK10.26969211
92PRKAA10.26891791
93MELK0.26627083
94LCK0.26085217
95ERBB20.25749122
96MKNK20.25719422
97PRKCI0.23504016
98MAPK140.23264415
99KDR0.23052766
100CSNK1E0.23009559

Predicted pathways (KEGG)

RankGene SetZ-score
1Other types of O-glycan biosynthesis_Homo sapiens_hsa005144.81980446
2SNARE interactions in vesicular transport_Homo sapiens_hsa041303.85089914
3NOD-like receptor signaling pathway_Homo sapiens_hsa046212.50908474
4Phototransduction_Homo sapiens_hsa047442.34874592
5Sulfur relay system_Homo sapiens_hsa041222.29244640
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27831925
7Regulation of autophagy_Homo sapiens_hsa041402.21221228
8RNA polymerase_Homo sapiens_hsa030202.06200452
9Nicotine addiction_Homo sapiens_hsa050332.02002445
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00130840
11Oxidative phosphorylation_Homo sapiens_hsa001901.94436896
12Linoleic acid metabolism_Homo sapiens_hsa005911.89362915
13Basal transcription factors_Homo sapiens_hsa030221.86059195
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79292345
15Homologous recombination_Homo sapiens_hsa034401.66915603
16Butanoate metabolism_Homo sapiens_hsa006501.62877006
17Insulin secretion_Homo sapiens_hsa049111.59556712
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59173154
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.55234192
20Huntingtons disease_Homo sapiens_hsa050161.48181530
21Ribosome_Homo sapiens_hsa030101.47570746
22Nitrogen metabolism_Homo sapiens_hsa009101.45728685
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45568247
24Cardiac muscle contraction_Homo sapiens_hsa042601.45196662
25Caffeine metabolism_Homo sapiens_hsa002321.42271570
26Parkinsons disease_Homo sapiens_hsa050121.39461072
27Ether lipid metabolism_Homo sapiens_hsa005651.35995553
28Taste transduction_Homo sapiens_hsa047421.35266090
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31985604
30Fanconi anemia pathway_Homo sapiens_hsa034601.23754094
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.21693192
32Cocaine addiction_Homo sapiens_hsa050301.20035792
33Olfactory transduction_Homo sapiens_hsa047401.11591379
34Primary immunodeficiency_Homo sapiens_hsa053401.10292147
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08547856
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.04839894
37ABC transporters_Homo sapiens_hsa020101.01887926
38Peroxisome_Homo sapiens_hsa041460.99216676
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96488922
40Dopaminergic synapse_Homo sapiens_hsa047280.94992751
41Amphetamine addiction_Homo sapiens_hsa050310.87487511
42Graft-versus-host disease_Homo sapiens_hsa053320.87363859
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87320740
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86338178
45TNF signaling pathway_Homo sapiens_hsa046680.85836358
46Circadian rhythm_Homo sapiens_hsa047100.84328986
47Alzheimers disease_Homo sapiens_hsa050100.82626473
48Nucleotide excision repair_Homo sapiens_hsa034200.79022892
49Collecting duct acid secretion_Homo sapiens_hsa049660.78186796
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.77238704
51Morphine addiction_Homo sapiens_hsa050320.76723018
52GABAergic synapse_Homo sapiens_hsa047270.76106149
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74900539
54RNA degradation_Homo sapiens_hsa030180.73738896
55Circadian entrainment_Homo sapiens_hsa047130.73176790
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73135733
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72795439
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72123611
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71209878
60Selenocompound metabolism_Homo sapiens_hsa004500.70861543
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70761687
62Chemical carcinogenesis_Homo sapiens_hsa052040.69303031
63Tryptophan metabolism_Homo sapiens_hsa003800.68383667
64Ovarian steroidogenesis_Homo sapiens_hsa049130.68332675
65Fatty acid degradation_Homo sapiens_hsa000710.67741509
66cAMP signaling pathway_Homo sapiens_hsa040240.67421062
67Glutamatergic synapse_Homo sapiens_hsa047240.66927058
68Serotonergic synapse_Homo sapiens_hsa047260.64942192
69Retinol metabolism_Homo sapiens_hsa008300.64699764
70Propanoate metabolism_Homo sapiens_hsa006400.64294157
71Salivary secretion_Homo sapiens_hsa049700.62385103
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61834582
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60518186
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60473457
75Toxoplasmosis_Homo sapiens_hsa051450.59337999
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.58038170
77Glycerolipid metabolism_Homo sapiens_hsa005610.57634907
78Purine metabolism_Homo sapiens_hsa002300.56686404
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56435918
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.56302262
81Calcium signaling pathway_Homo sapiens_hsa040200.54390513
82Mineral absorption_Homo sapiens_hsa049780.52683638
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51783575
84Histidine metabolism_Homo sapiens_hsa003400.50870211
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.49923190
86Leishmaniasis_Homo sapiens_hsa051400.48956445
87Cholinergic synapse_Homo sapiens_hsa047250.48009950
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.47661939
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47231192
90Pyrimidine metabolism_Homo sapiens_hsa002400.43325012
91Thyroid hormone synthesis_Homo sapiens_hsa049180.43285650
92Type I diabetes mellitus_Homo sapiens_hsa049400.42885791
93Glucagon signaling pathway_Homo sapiens_hsa049220.42295978
94Gastric acid secretion_Homo sapiens_hsa049710.42231496
95Sulfur metabolism_Homo sapiens_hsa009200.41782026
96MAPK signaling pathway_Homo sapiens_hsa040100.41159176
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40827538
98Arachidonic acid metabolism_Homo sapiens_hsa005900.39468120
99AMPK signaling pathway_Homo sapiens_hsa041520.39025580
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38239441

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