HK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.95156131
2neutrophil mediated immunity (GO:0002446)5.93944858
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.87880064
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.87880064
5modulation by symbiont of host immune response (GO:0052553)5.87880064
6positive regulation by symbiont of host defense response (GO:0052509)5.87880064
7modulation by symbiont of host defense response (GO:0052031)5.87880064
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.87880064
9respiratory burst (GO:0045730)5.53405511
10detection of other organism (GO:0098543)5.34718582
11response to peptidoglycan (GO:0032494)5.28835419
12positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.18811326
13detection of bacterium (GO:0016045)5.11037224
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.93589926
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.93589926
16regulation of interferon-beta biosynthetic process (GO:0045357)4.83393323
17response to fungus (GO:0009620)4.68865797
18detection of external biotic stimulus (GO:0098581)4.48492267
19myeloid leukocyte mediated immunity (GO:0002444)4.48342567
20negative regulation of phagocytosis (GO:0050765)4.43678873
21macrophage activation involved in immune response (GO:0002281)4.42232957
22disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.39837546
23killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.39837546
24regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.34082656
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.29112204
26detection of molecule of bacterial origin (GO:0032490)4.24273242
27antigen processing and presentation of endogenous antigen (GO:0019883)4.18234018
28neutrophil activation (GO:0042119)4.18150081
29regulation of B cell receptor signaling pathway (GO:0050855)4.16527694
30response to muramyl dipeptide (GO:0032495)4.13523687
31leukocyte mediated cytotoxicity (GO:0001909)4.07696543
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.06639955
33response to host immune response (GO:0052572)4.06639955
34granulocyte activation (GO:0036230)4.04702646
35leukocyte migration involved in inflammatory response (GO:0002523)4.03687236
36positive regulation of interferon-alpha production (GO:0032727)3.99885464
37defense response to fungus (GO:0050832)3.99840650
38detection of biotic stimulus (GO:0009595)3.99712592
39reactive oxygen species biosynthetic process (GO:1903409)3.98852173
40immunoglobulin mediated immune response (GO:0016064)3.96002786
41regulation of gamma-delta T cell activation (GO:0046643)3.93689887
42leukocyte aggregation (GO:0070486)3.92446071
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.91878457
44modulation of growth of symbiont involved in interaction with host (GO:0044144)3.90906646
45regulation of growth of symbiont in host (GO:0044126)3.90906646
46negative regulation of growth of symbiont in host (GO:0044130)3.90906646
47negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.90906646
48myeloid cell activation involved in immune response (GO:0002275)3.90402375
49pinocytosis (GO:0006907)3.85631766
50cellular extravasation (GO:0045123)3.79434554
51positive regulation of gamma-delta T cell activation (GO:0046645)3.78920687
52leukotriene metabolic process (GO:0006691)3.77879044
53regulation of interferon-alpha production (GO:0032647)3.77608990
54positive regulation of antigen processing and presentation (GO:0002579)3.76974124
55negative regulation of lymphocyte mediated immunity (GO:0002707)3.69972812
56positive regulation of B cell differentiation (GO:0045579)3.69631896
57regulation of mast cell degranulation (GO:0043304)3.66964193
58response to host defenses (GO:0052200)3.65539407
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.65539407
60response to host (GO:0075136)3.65539407
61regulation of mast cell activation (GO:0033003)3.64021148
62positive regulation of mast cell degranulation (GO:0043306)3.63689825
63positive regulation of mast cell activation involved in immune response (GO:0033008)3.63689825
64Arp2/3 complex-mediated actin nucleation (GO:0034314)3.60433193
65cellular response to interferon-beta (GO:0035458)3.59902318
66regulation of interleukin-8 biosynthetic process (GO:0045414)3.52281038
67negative regulation of erythrocyte differentiation (GO:0045647)3.47899654
68regulation of mast cell activation involved in immune response (GO:0033006)3.47579066
69leukotriene biosynthetic process (GO:0019370)3.47081831
70natural killer cell mediated cytotoxicity (GO:0042267)3.46081456
71natural killer cell mediated immunity (GO:0002228)3.46081456
72negative regulation of cell killing (GO:0031342)3.44374330
73negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.44374330
74positive regulation of cellular amide metabolic process (GO:0034250)3.44078804
75positive regulation of mast cell activation (GO:0033005)3.43571307
76negative regulation of leukocyte mediated immunity (GO:0002704)3.40014876
77regulation of leukocyte degranulation (GO:0043300)3.39292970
78positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.31494727
79superoxide anion generation (GO:0042554)3.31393905
80regulation of myeloid leukocyte mediated immunity (GO:0002886)3.30535502
81hydrogen peroxide biosynthetic process (GO:0050665)3.28446306
82negative regulation of T cell mediated immunity (GO:0002710)3.27349093
83positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.27204197
84defense response to protozoan (GO:0042832)3.25440398
85regulation of regulated secretory pathway (GO:1903305)3.22309747
86disruption of cells of other organism (GO:0044364)3.20862109
87killing of cells of other organism (GO:0031640)3.20862109
88negative regulation of mast cell activation (GO:0033004)3.20583967
89pentose-phosphate shunt (GO:0006098)3.18270401
90leukocyte degranulation (GO:0043299)3.17760383
91regulation of antigen processing and presentation (GO:0002577)3.14794482
92regulation of gamma-delta T cell differentiation (GO:0045586)3.13526493
93response to interferon-beta (GO:0035456)3.12920826
94neutrophil chemotaxis (GO:0030593)3.12071042
95regulation of tolerance induction (GO:0002643)3.11927013
96regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.11024349
97regulation of T-helper 2 cell differentiation (GO:0045628)3.09327506
98regulation of T cell tolerance induction (GO:0002664)3.09144087
99positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.07466831
100macrophage differentiation (GO:0030225)3.05816187
101positive regulation of leukocyte degranulation (GO:0043302)3.05623444
102production of molecular mediator involved in inflammatory response (GO:0002532)3.05596789
103germinal center formation (GO:0002467)3.05577020
104response to protozoan (GO:0001562)3.03341828
105neutrophil migration (GO:1990266)3.02940458
106cellular response to type I interferon (GO:0071357)3.02804819
107type I interferon signaling pathway (GO:0060337)3.02804819
108phagosome maturation (GO:0090382)3.02610869
109myeloid leukocyte activation (GO:0002274)3.01667333
110response to type I interferon (GO:0034340)3.01322870
111negative regulation of cytokine production involved in immune response (GO:0002719)3.01093596
112microglial cell activation (GO:0001774)3.00920797
113lipopolysaccharide-mediated signaling pathway (GO:0031663)3.00489514
114macrophage activation (GO:0042116)2.99327898
115cellular response to zinc ion (GO:0071294)2.98129667
116cell killing (GO:0001906)2.96836147
117negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.96237016
118antigen processing and presentation via MHC class Ib (GO:0002475)2.94688049
119granulocyte chemotaxis (GO:0071621)2.93322897
120regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93132368
121negative regulation of interleukin-6 production (GO:0032715)2.92628305
122NADPH regeneration (GO:0006740)2.92342741
123B cell receptor signaling pathway (GO:0050853)2.91199445
124interferon-gamma-mediated signaling pathway (GO:0060333)2.90632629
125negative regulation of interleukin-12 production (GO:0032695)2.90188715
126amino sugar catabolic process (GO:0046348)2.88355311
127positive regulation of interferon-beta production (GO:0032728)2.88325820
128negative regulation of innate immune response (GO:0045824)2.88133826
129regulation of B cell differentiation (GO:0045577)2.88051569
130mannose metabolic process (GO:0006013)2.87264480
131B cell mediated immunity (GO:0019724)2.87109946
132leukocyte cell-cell adhesion (GO:0007159)2.86065527
133sequestering of metal ion (GO:0051238)2.84450321
134granulocyte migration (GO:0097530)2.84359329
135negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.83412643
136positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.80291117
137positive regulation of regulated secretory pathway (GO:1903307)2.79597155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_21731497_ChIP-ChIP_J774_Mouse5.49405831
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.90996413
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.62069994
4E2F7_22180533_ChIP-Seq_HELA_Human4.29043886
5MYB_21317192_ChIP-Seq_ERMYB_Mouse4.00897620
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.94467600
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.91613374
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.74373465
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.56977827
10* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.10789562
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.06330173
12VDR_21846776_ChIP-Seq_THP-1_Human3.02624229
13* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.84178400
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.79215532
15BRD4_27068464_Chip-Seq_AML-cells_Mouse2.76141845
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.74327334
17* SPI1_23547873_ChIP-Seq_NB4_Human2.69474267
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.68164373
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58565903
20SCL_19346495_ChIP-Seq_HPC-7_Human2.54489680
21VDR_24763502_ChIP-Seq_THP-1_Human2.39956609
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.37240118
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31664658
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.17748668
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.17159991
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.15667778
27GATA1_22025678_ChIP-Seq_K562_Human2.14193762
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.11777087
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04055725
30SPI1_23127762_ChIP-Seq_K562_Human2.03204686
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89658543
32MYC_22102868_ChIP-Seq_BL_Human1.83942225
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.83778400
34MYB_26560356_Chip-Seq_TH2_Human1.78801522
35* MAF_26560356_Chip-Seq_TH1_Human1.76926975
36PU_27001747_Chip-Seq_BMDM_Mouse1.74177602
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70980452
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.67266153
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66012024
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63405931
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.62766380
42MYB_26560356_Chip-Seq_TH1_Human1.60594750
43UTX_26944678_Chip-Seq_JUKART_Human1.57220820
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57199814
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54085129
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50241897
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47831440
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47396157
49TCF7_22412390_ChIP-Seq_EML_Mouse1.46674242
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43718176
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43538542
52TFEB_21752829_ChIP-Seq_HELA_Human1.42220524
53* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40274810
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38903786
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37764658
56GATA1_19941826_ChIP-Seq_K562_Human1.33729456
57* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33501382
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31072896
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30649525
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28647726
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27792677
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25948510
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24716335
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.24622993
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24421908
66GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23767439
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23642219
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22773737
69RUNX_20019798_ChIP-Seq_JUKART_Human1.21965909
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21097755
71VDR_24787735_ChIP-Seq_THP-1_Human1.19927440
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19492727
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19391725
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17063221
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14907658
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12973046
77E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12902144
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.12818096
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11567324
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.10837546
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09396228
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09375577
83* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08316367
84GATA3_27048872_Chip-Seq_THYMUS_Human1.08215132
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07964490
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07870449
87GATA3_26560356_Chip-Seq_TH2_Human1.07189433
88BCOR_27268052_Chip-Seq_Bcells_Human1.05864647
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05576445
90* MAF_26560356_Chip-Seq_TH2_Human1.05299838
91KDM2B_26808549_Chip-Seq_JURKAT_Human1.02687673
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00569855
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93259574
94KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92320268
95SPI1_20517297_ChIP-Seq_HL60_Human0.91512498
96NCOR1_26117541_ChIP-Seq_K562_Human0.89328610
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87060589
98PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86261436
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86251512
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.85892250
101KDM2B_26808549_Chip-Seq_DND41_Human0.85517882
102LXR_22292898_ChIP-Seq_THP-1_Human0.85416337
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83848432
104E2F1_21310950_ChIP-Seq_MCF-7_Human0.82705467
105CIITA_25753668_ChIP-Seq_RAJI_Human0.82627274
106FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.78601756
107KDM2B_26808549_Chip-Seq_K562_Human0.77188990
108ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74818595
109GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74684258
110BCL6_27268052_Chip-Seq_Bcells_Human0.73320094
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.72915220
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72472387
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72169475
114GATA2_19941826_ChIP-Seq_K562_Human0.70117225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.74666024
2MP0003303_peritoneal_inflammation4.07088897
3MP0003172_abnormal_lysosome_physiology3.65863553
4MP0001835_abnormal_antigen_presentation3.62905971
5MP0003436_decreased_susceptibility_to3.59638584
6MP0002419_abnormal_innate_immunity3.26173832
7MP0009785_altered_susceptibility_to2.98639915
8MP0000569_abnormal_digit_pigmentation2.83030948
9MP0005464_abnormal_platelet_physiology2.69522612
10MP0005025_abnormal_response_to2.68434580
11MP0003183_abnormal_peptide_metabolism2.54378784
12MP0005000_abnormal_immune_tolerance2.51234549
13MP0002148_abnormal_hypersensitivity_rea2.49480945
14MP0005174_abnormal_tail_pigmentation2.44640883
15MP0002452_abnormal_antigen_presenting2.37257731
16MP0006082_CNS_inflammation2.22556995
17MP0002723_abnormal_immune_serum2.16103685
18MP0001800_abnormal_humoral_immune2.16042218
19MP0009840_abnormal_foam_cell2.14273687
20MP0001819_abnormal_immune_cell2.13012817
21MP0002420_abnormal_adaptive_immunity2.12487994
22MP0005387_immune_system_phenotype2.10391999
23MP0001790_abnormal_immune_system2.10391999
24MP0004510_myositis2.10003347
25MP0000685_abnormal_immune_system2.07282013
26MP0009278_abnormal_bone_marrow2.06100630
27MP0002396_abnormal_hematopoietic_system2.02613073
28MP0001533_abnormal_skeleton_physiology1.98533409
29MP0005671_abnormal_response_to1.96573701
30MP0000015_abnormal_ear_pigmentation1.95150046
31MP0010307_abnormal_tumor_latency1.93154306
32MP0003724_increased_susceptibility_to1.85808714
33MP0002405_respiratory_system_inflammati1.85555754
34MP0001853_heart_inflammation1.82158652
35MP0000343_altered_response_to1.81170178
36MP0005397_hematopoietic_system_phenotyp1.80585802
37MP0001545_abnormal_hematopoietic_system1.80585802
38MP0001845_abnormal_inflammatory_respons1.72422566
39MP0003300_gastrointestinal_ulcer1.72211908
40MP0003191_abnormal_cellular_cholesterol1.71570715
41MP0000716_abnormal_immune_system1.66416952
42MP0000604_amyloidosis1.65972654
43MP0002398_abnormal_bone_marrow1.65934643
44MP0002166_altered_tumor_susceptibility1.60896728
45MP0000465_gastrointestinal_hemorrhage1.60449345
46MP0005451_abnormal_body_composition1.59352768
47MP0000689_abnormal_spleen_morphology1.56885218
48MP0004947_skin_inflammation1.54903780
49MP0003448_altered_tumor_morphology1.54280409
50MP0003075_altered_response_to1.53819605
51MP0004808_abnormal_hematopoietic_stem1.51739756
52MP0008469_abnormal_protein_level1.50059762
53MP0010155_abnormal_intestine_physiology1.45353105
54MP0000858_altered_metastatic_potential1.44887177
55MP0002722_abnormal_immune_system1.44640715
56MP0002429_abnormal_blood_cell1.43748707
57MP0003806_abnormal_nucleotide_metabolis1.43370042
58MP0001851_eye_inflammation1.35051336
59MP0009333_abnormal_splenocyte_physiolog1.31949761
60MP0002132_abnormal_respiratory_system1.30536369
61MP0002006_tumorigenesis1.27272220
62MP0003656_abnormal_erythrocyte_physiolo1.21482675
63MP0003566_abnormal_cell_adhesion1.19352722
64MP0003690_abnormal_glial_cell1.14998927
65MP0009764_decreased_sensitivity_to1.14059487
66MP0000490_abnormal_crypts_of1.12653485
67MP0005257_abnormal_intraocular_pressure1.11307635
68MP0002998_abnormal_bone_remodeling1.05760648
69MP0001873_stomach_inflammation0.99078619
70MP0008004_abnormal_stomach_pH0.98324216
71MP0002277_abnormal_respiratory_mucosa0.96444510
72MP0005166_decreased_susceptibility_to0.96299690
73MP0005310_abnormal_salivary_gland0.94876788
74MP0003329_amyloid_beta_deposits0.94168822
75MP0002933_joint_inflammation0.92160038
76MP0000371_diluted_coat_color0.91483802
77MP0009763_increased_sensitivity_to0.86015795
78MP0002095_abnormal_skin_pigmentation0.84931080
79MP0000703_abnormal_thymus_morphology0.84835138
80MP0005164_abnormal_response_to0.80904784
81MP0003763_abnormal_thymus_physiology0.80175797
82MP0005075_abnormal_melanosome_morpholog0.78548254
83MP0008260_abnormal_autophagy0.78520026
84MP0001663_abnormal_digestive_system0.78371000
85MP0005390_skeleton_phenotype0.77306262
86MP0004381_abnormal_hair_follicle0.76710958
87MP0003186_abnormal_redox_activity0.76196785
88MP0004782_abnormal_surfactant_physiolog0.76096141
89MP0005023_abnormal_wound_healing0.74990727
90MP0000249_abnormal_blood_vessel0.74782789
91MP0000920_abnormal_myelination0.74091344
92MP0003828_pulmonary_edema0.73377663
93MP0003693_abnormal_embryo_hatching0.72847443
94MP0002019_abnormal_tumor_incidence0.71329945
95MP0005076_abnormal_cell_differentiation0.70316971
96MP0009765_abnormal_xenobiotic_induced0.68681596
97MP0003453_abnormal_keratinocyte_physiol0.68665409
98MP0005167_abnormal_blood-brain_barrier0.68440032
99MP0003795_abnormal_bone_structure0.68244657
100MP0008874_decreased_physiological_sensi0.68189959
101MP0003091_abnormal_cell_migration0.67169774
102MP0001958_emphysema0.64045296
103MP0008873_increased_physiological_sensi0.61444829
104MP0002138_abnormal_hepatobiliary_system0.58359754
105MP0003866_abnormal_defecation0.58142856
106MP0001986_abnormal_taste_sensitivity0.57925709
107MP0000598_abnormal_liver_morphology0.56714004
108MP0005621_abnormal_cell_physiology0.53488737
109MP0000313_abnormal_cell_death0.52261289
110MP0003045_fibrosis0.50622726
111MP0002332_abnormal_exercise_endurance0.50546015
112MP0006054_spinal_hemorrhage0.49846733
113MP0005319_abnormal_enzyme/_coenzyme0.49238828
114MP0004883_abnormal_blood_vessel0.48949150
115MP0003221_abnormal_cardiomyocyte_apopto0.48839024
116MP0005365_abnormal_bile_salt0.48681412
117MP0003111_abnormal_nucleus_morphology0.48667822
118MP0010094_abnormal_chromosome_stability0.47542475
119MP0010352_gastrointestinal_tract_polyps0.47105017

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.29492853
2Eczematoid dermatitis (HP:0000976)6.72440879
3Recurrent bacterial skin infections (HP:0005406)6.50025228
4Recurrent gram-negative bacterial infections (HP:0005420)5.48929601
5Increased cerebral lipofuscin (HP:0011813)5.11999030
6Vacuolated lymphocytes (HP:0001922)4.93493743
7Abnormality of macrophages (HP:0004311)4.74765021
8Dysostosis multiplex (HP:0000943)4.70637029
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.44719489
10Obstructive lung disease (HP:0006536)4.41857390
11Chronic obstructive pulmonary disease (HP:0006510)4.41857390
12Elevated erythrocyte sedimentation rate (HP:0003565)4.15097911
13Mediastinal lymphadenopathy (HP:0100721)4.14287975
14Myositis (HP:0100614)3.98922435
15Recurrent skin infections (HP:0001581)3.95472149
16Gingivitis (HP:0000230)3.81147824
17Urinary glycosaminoglycan excretion (HP:0003541)3.76209854
18Mucopolysacchariduria (HP:0008155)3.76209854
19Abnormality of liposaccharide metabolism (HP:0010968)3.68063332
20Abnormality of glycosphingolipid metabolism (HP:0004343)3.68063332
21Abnormality of glycolipid metabolism (HP:0010969)3.68063332
22Recurrent fungal infections (HP:0002841)3.62739749
23Abnormality of polysaccharide metabolism (HP:0011012)3.57399415
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.57399415
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.57399415
26Systemic lupus erythematosus (HP:0002725)3.51862432
27Periodontitis (HP:0000704)3.47758892
28Gastrointestinal infarctions (HP:0005244)3.33107540
29Chronic otitis media (HP:0000389)3.30162829
30Stomatitis (HP:0010280)3.26738002
31Thrombocytosis (HP:0001894)3.24426843
32Amyloidosis (HP:0011034)3.13993508
33Petechiae (HP:0000967)3.07871261
34Keratoconjunctivitis sicca (HP:0001097)3.07595882
35Abnormal delayed hypersensitivity skin test (HP:0002963)3.02709332
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.97535189
37Disinhibition (HP:0000734)2.96846589
38Cellulitis (HP:0100658)2.95430831
39Encephalitis (HP:0002383)2.94770110
40Axonal loss (HP:0003447)2.94171060
41Orchitis (HP:0100796)2.91089807
42Recurrent viral infections (HP:0004429)2.90263171
43Hepatosplenomegaly (HP:0001433)2.84873022
44Meningitis (HP:0001287)2.83431779
45Keratoconjunctivitis (HP:0001096)2.81355447
46Autoimmune thrombocytopenia (HP:0001973)2.80085602
47Increased IgE level (HP:0003212)2.76533625
48Osteomyelitis (HP:0002754)2.75172943
49Agnosia (HP:0010524)2.71879979
50Purpura (HP:0000979)2.68852971
51Loss of speech (HP:0002371)2.68143403
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.65515490
53Episodic fever (HP:0001954)2.64008912
54Urticaria (HP:0001025)2.63984963
55Leukocytosis (HP:0001974)2.61640684
56Thoracic kyphosis (HP:0002942)2.60470535
57J-shaped sella turcica (HP:0002680)2.59898283
58Increased serum ferritin (HP:0003281)2.58950195
59Abnormality of the prostate (HP:0008775)2.55396935
60Recurrent cutaneous fungal infections (HP:0011370)2.53311013
61Chronic mucocutaneous candidiasis (HP:0002728)2.53311013
62Vasculitis (HP:0002633)2.52826876
63Interstitial pulmonary disease (HP:0006530)2.51874326
64Eosinophilia (HP:0001880)2.48836582
65T lymphocytopenia (HP:0005403)2.47846614
66Retrobulbar optic neuritis (HP:0100654)2.41539646
67Optic neuritis (HP:0100653)2.41539646
68Anorexia (HP:0002039)2.40313812
69Pulmonary infiltrates (HP:0002113)2.37761271
70Hypochromic microcytic anemia (HP:0004840)2.37720290
71Spontaneous hematomas (HP:0007420)2.36651870
72Epistaxis (HP:0000421)2.36316221
73Abnormality of T cell number (HP:0011839)2.32519086
74Chest pain (HP:0100749)2.32484310
75Basal ganglia calcification (HP:0002135)2.31360813
76Abnormality of iron homeostasis (HP:0011031)2.31246658
77Abnormality of the lumbar spine (HP:0100712)2.29467130
78Mutism (HP:0002300)2.27064328
79Abnormality of the thoracic spine (HP:0100711)2.26469423
80Abnormality of the vasculature of the conjunctiva (HP:0008054)2.25613626
81Granulocytopenia (HP:0001913)2.25276009
82Premature loss of primary teeth (HP:0006323)2.23189238
83Pustule (HP:0200039)2.23080782
84Colitis (HP:0002583)2.22950527
85Myocardial infarction (HP:0001658)2.22812817
86Pulmonary embolism (HP:0002204)2.22236017
87Hemoptysis (HP:0002105)2.21551848
88Hypochromic anemia (HP:0001931)2.21525804
89IgM deficiency (HP:0002850)2.19573150
90Pathologic fracture (HP:0002756)2.18800331
91Increased IgM level (HP:0003496)2.17366647
92Glomerulonephritis (HP:0000099)2.16302829
93Joint hemorrhage (HP:0005261)2.15605842
94Prolonged bleeding time (HP:0003010)2.11520543
95Asymmetric septal hypertrophy (HP:0001670)2.11486492
96Gingival bleeding (HP:0000225)2.11406119
97Conjunctival telangiectasia (HP:0000524)2.10422452
98Prostate neoplasm (HP:0100787)2.10239440
99Recurrent pneumonia (HP:0006532)2.09807380
100Malnutrition (HP:0004395)2.07806980
101Abnormal platelet function (HP:0011869)2.06280171
102Impaired platelet aggregation (HP:0003540)2.06280171
103Nasal polyposis (HP:0100582)2.04167375
104Osteolytic defects of the phalanges of the hand (HP:0009771)2.03920641
105Osteolytic defects of the hand bones (HP:0009699)2.03920641
106Global brain atrophy (HP:0002283)2.01348282
107Peritonitis (HP:0002586)2.01236516
108Diminished motivation (HP:0000745)1.99203884
109Neuronal loss in central nervous system (HP:0002529)1.98786245
110Skin ulcer (HP:0200042)1.96927991
111Panhypogammaglobulinemia (HP:0003139)1.95969198
112Polyneuropathy (HP:0001271)1.95363027
113Sepsis (HP:0100806)1.95340357
114Abnormality of T cells (HP:0002843)1.94541654
115Arterial thrombosis (HP:0004420)1.93331159
116Hypergammaglobulinemia (HP:0010702)1.92950200
117Inflammation of the large intestine (HP:0002037)1.92859749
118Gangrene (HP:0100758)1.92725728
119Hematochezia (HP:0002573)1.92424471
120Progressive neurologic deterioration (HP:0002344)1.92413489
121Abnormality of the pleura (HP:0002103)1.91600456
122Glomerulopathy (HP:0100820)1.90217855
123B lymphocytopenia (HP:0010976)1.89532784
124Abnormality of B cell number (HP:0010975)1.89532784
125Deformed sella turcica (HP:0002681)1.89447152
126Abnormality of the endocardium (HP:0004306)1.88543970
127Apathy (HP:0000741)1.88158063
128Vertigo (HP:0002321)1.88152508
129Bone pain (HP:0002653)1.86652206
130Microcytic anemia (HP:0001935)1.85988331
131Neurodegeneration (HP:0002180)1.85464656
132Upper motor neuron abnormality (HP:0002127)1.85453687
133Abnormality of transition element cation homeostasis (HP:0011030)1.84929926
134Gastrointestinal inflammation (HP:0004386)1.84649070
135Personality changes (HP:0000751)1.84570643
136Abnormality of eosinophils (HP:0001879)1.83515708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK43.78980987
2KIT3.35178069
3BLK3.16952418
4TAOK33.09741933
5RIPK43.02087131
6TBK12.70476670
7TYK22.67015061
8MAP4K12.58883644
9IRAK32.54402300
10FES2.53425024
11ERN12.46588008
12PRPF4B2.41900363
13CSF1R2.37798206
14MAP3K142.19095726
15TNK22.09160751
16MAP2K32.08299719
17BTK2.07870406
18TAOK11.94368591
19TEC1.90272153
20PKN21.87904872
21EPHB11.73702322
22ZAP701.64639790
23SYK1.62973205
24TGFBR21.62145914
25IKBKE1.61533853
26HCK1.51478251
27CLK11.45482086
28STK101.43504559
29FGR1.43449981
30TRIB31.41497071
31PIM21.39413565
32JAK11.32738307
33TTN1.31928194
34CSK1.29850532
35TAOK21.28073945
36JAK31.27889087
37IKBKB1.26174682
38TRPM71.23667862
39MAP3K11.23650571
40TESK21.22937803
41EEF2K1.22549718
42GRK61.22475714
43SIK21.20593015
44LYN1.16760605
45PAK41.16673278
46LCK1.13919343
47KSR21.11500324
48MARK31.05552863
49MAP3K131.05201213
50SIK31.03896944
51BMX1.00913732
52FLT31.00656979
53TXK0.99374057
54MATK0.97600088
55SCYL20.97131346
56JAK20.96914470
57PTK60.96137360
58MARK20.91910010
59ITK0.90359572
60PDPK10.90264394
61BMPR20.89781164
62RPS6KA40.89044111
63CDC42BPA0.89040540
64CAMK1D0.86839690
65MAP3K60.84767031
66LRRK20.84701732
67IRAK20.84396663
68PIM10.81769418
69NEK20.81453189
70PBK0.81188677
71NME20.77754290
72PRKD20.73305138
73IRAK10.72758385
74NEK90.72628393
75MAPK120.72477998
76MAP3K110.70889179
77TESK10.70354002
78RPS6KA60.69768400
79CDK60.69252521
80STK40.66113480
81MAPK40.65696424
82RPS6KA20.65194459
83RPS6KL10.62692212
84RPS6KC10.62692212
85MAP2K40.62635408
86MAPK70.62445968
87CAMK1G0.62250874
88EGFR0.61553354
89ABL20.59774351
90MAP3K120.59634194
91CAMKK20.58430745
92MOS0.58388424
93GRK70.57215176
94PRKCD0.55406181
95MAP3K30.55397487
96MAP2K60.54605542
97CHUK0.53791157
98EIF2AK20.53329251
99ATR0.53111034
100SGK30.52617096
101MAP3K80.52444323
102PTK2B0.52115330
103DAPK20.50339577
104WEE10.48649643
105ABL10.48038674
106MAP3K20.46986534
107MAP3K50.45919412
108DAPK10.43675654
109MAPKAPK20.41912923
110KSR10.41720034
111BRSK20.41276790
112ALK0.41248767
113CDK190.40832800
114PRKCQ0.39517228
115MAP3K70.39511767
116STK110.39482758
117RET0.39282750
118CAMKK10.38208441
119PIK3CG0.37704885
120RIPK10.37162542
121SMG10.36577792
122CDK40.36394607
123DYRK1B0.35902655
124PDK10.35368591
125YES10.32120353
126FYN0.31270566
127HIPK20.30747825
128EIF2AK30.27619650
129PRKG20.25856190
130MAPK110.25561564
131MAP3K100.25341351

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.80731609
2Leishmaniasis_Homo sapiens_hsa051403.47928973
3Other glycan degradation_Homo sapiens_hsa005113.16245642
4Lysosome_Homo sapiens_hsa041423.11054990
5Staphylococcus aureus infection_Homo sapiens_hsa051502.74717609
6Osteoclast differentiation_Homo sapiens_hsa043802.60427110
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.38958430
8Tuberculosis_Homo sapiens_hsa051522.24970811
9Pertussis_Homo sapiens_hsa051332.24139828
10Legionellosis_Homo sapiens_hsa051342.04020339
11Phagosome_Homo sapiens_hsa041451.99870981
12B cell receptor signaling pathway_Homo sapiens_hsa046621.98785450
13Autoimmune thyroid disease_Homo sapiens_hsa053201.95425714
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.94183801
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.93883165
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.89615668
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85303411
18Malaria_Homo sapiens_hsa051441.81702744
19Antigen processing and presentation_Homo sapiens_hsa046121.78635324
20Measles_Homo sapiens_hsa051621.69613418
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.68510243
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67999211
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60208052
24Influenza A_Homo sapiens_hsa051641.57596864
25Type I diabetes mellitus_Homo sapiens_hsa049401.56792735
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.49032199
27Salmonella infection_Homo sapiens_hsa051321.47817836
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46634562
29Shigellosis_Homo sapiens_hsa051311.45469335
30Apoptosis_Homo sapiens_hsa042101.45286202
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41823532
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.39068149
33Asthma_Homo sapiens_hsa053101.38846824
34Toxoplasmosis_Homo sapiens_hsa051451.38271379
35Herpes simplex infection_Homo sapiens_hsa051681.34956561
36TNF signaling pathway_Homo sapiens_hsa046681.30527488
37Chemokine signaling pathway_Homo sapiens_hsa040621.27521133
38Hematopoietic cell lineage_Homo sapiens_hsa046401.27299447
39Caffeine metabolism_Homo sapiens_hsa002321.26025630
40Rheumatoid arthritis_Homo sapiens_hsa053231.19759635
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17118750
42DNA replication_Homo sapiens_hsa030301.14094840
43Pentose phosphate pathway_Homo sapiens_hsa000301.13841842
44Hepatitis B_Homo sapiens_hsa051611.13702199
45Renin-angiotensin system_Homo sapiens_hsa046141.12871305
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.12220507
47Primary immunodeficiency_Homo sapiens_hsa053401.04247776
48Acute myeloid leukemia_Homo sapiens_hsa052211.01926387
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.00196890
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96202805
51African trypanosomiasis_Homo sapiens_hsa051430.96049570
52Hepatitis C_Homo sapiens_hsa051600.95544974
53Chronic myeloid leukemia_Homo sapiens_hsa052200.94137621
54Platelet activation_Homo sapiens_hsa046110.91897024
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86379266
56Base excision repair_Homo sapiens_hsa034100.84493844
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.82786662
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82267033
59Amoebiasis_Homo sapiens_hsa051460.78471683
60One carbon pool by folate_Homo sapiens_hsa006700.77366512
61Pancreatic cancer_Homo sapiens_hsa052120.76698034
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76608891
63Allograft rejection_Homo sapiens_hsa053300.76211194
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75160777
65Viral myocarditis_Homo sapiens_hsa054160.74324129
66VEGF signaling pathway_Homo sapiens_hsa043700.69133665
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67194885
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65952661
69Graft-versus-host disease_Homo sapiens_hsa053320.65451994
70Selenocompound metabolism_Homo sapiens_hsa004500.65407778
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65337649
72Renal cell carcinoma_Homo sapiens_hsa052110.65132893
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65118718
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64962512
75Epstein-Barr virus infection_Homo sapiens_hsa051690.63668753
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62980793
77N-Glycan biosynthesis_Homo sapiens_hsa005100.61776204
78GnRH signaling pathway_Homo sapiens_hsa049120.60729181
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.59603249
80Complement and coagulation cascades_Homo sapiens_hsa046100.56480364
81Non-homologous end-joining_Homo sapiens_hsa034500.55617852
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55578371
83ABC transporters_Homo sapiens_hsa020100.54970634
84T cell receptor signaling pathway_Homo sapiens_hsa046600.53484053
85Viral carcinogenesis_Homo sapiens_hsa052030.53011217
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.51351152
87Bladder cancer_Homo sapiens_hsa052190.51048087
88Small cell lung cancer_Homo sapiens_hsa052220.50888994
89Non-small cell lung cancer_Homo sapiens_hsa052230.50519445
90Collecting duct acid secretion_Homo sapiens_hsa049660.50360558
91Sphingolipid metabolism_Homo sapiens_hsa006000.47415635
92FoxO signaling pathway_Homo sapiens_hsa040680.45495114
93* HIF-1 signaling pathway_Homo sapiens_hsa040660.44794202
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43554264
95Endocytosis_Homo sapiens_hsa041440.40909753
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40008330
97Choline metabolism in cancer_Homo sapiens_hsa052310.40005293
98* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39788164
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38805901
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38243580
101Endometrial cancer_Homo sapiens_hsa052130.37857579
102Dorso-ventral axis formation_Homo sapiens_hsa043200.36909981
103Prion diseases_Homo sapiens_hsa050200.36818368
104mTOR signaling pathway_Homo sapiens_hsa041500.36314824
105Homologous recombination_Homo sapiens_hsa034400.36045253
106MAPK signaling pathway_Homo sapiens_hsa040100.35805092
107Rap1 signaling pathway_Homo sapiens_hsa040150.34713275
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.33963652
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33528028
110Estrogen signaling pathway_Homo sapiens_hsa049150.32911169
111Mismatch repair_Homo sapiens_hsa034300.32756666
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.32333513
113Prolactin signaling pathway_Homo sapiens_hsa049170.31056596
114Regulation of autophagy_Homo sapiens_hsa041400.30631496
115HTLV-I infection_Homo sapiens_hsa051660.30385020
116Insulin resistance_Homo sapiens_hsa049310.29960447
117Arachidonic acid metabolism_Homo sapiens_hsa005900.29618757
118* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28789064
119p53 signaling pathway_Homo sapiens_hsa041150.27357913
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.27032663
121Notch signaling pathway_Homo sapiens_hsa043300.22466458
122Lysine degradation_Homo sapiens_hsa003100.22375967
123Glutathione metabolism_Homo sapiens_hsa004800.20619367

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