HIVEP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.71788428
2regulation of interleukin-12 biosynthetic process (GO:0045075)5.57519801
3positive regulation of gamma-delta T cell activation (GO:0046645)5.51358590
4regulation of interleukin-2 biosynthetic process (GO:0045076)4.49676320
5regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.42790919
6negative regulation of cell killing (GO:0031342)4.36768265
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.36768265
8regulation of vitamin D biosynthetic process (GO:0060556)4.26699775
9negative thymic T cell selection (GO:0045060)4.07106209
10negative T cell selection (GO:0043383)4.02584631
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.89700532
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.89700532
13modulation by symbiont of host immune response (GO:0052553)3.89700532
14positive regulation by symbiont of host defense response (GO:0052509)3.89700532
15modulation by symbiont of host defense response (GO:0052031)3.89700532
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.89700532
17regulation of gamma-delta T cell activation (GO:0046643)3.88602052
18response to interleukin-15 (GO:0070672)3.88517446
19regulation of gamma-delta T cell differentiation (GO:0045586)3.87159243
20positive thymic T cell selection (GO:0045059)3.86435981
21positive regulation of interleukin-2 production (GO:0032743)3.85905596
22positive T cell selection (GO:0043368)3.84593898
23positive regulation of T cell cytokine production (GO:0002726)3.81438882
24regulation of vitamin metabolic process (GO:0030656)3.76517976
25CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.73095212
26regulation of isotype switching to IgG isotypes (GO:0048302)3.70044442
27myeloid dendritic cell differentiation (GO:0043011)3.67579419
28positive regulation of humoral immune response (GO:0002922)3.63529936
29activated T cell proliferation (GO:0050798)3.60019059
30CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.56847242
31T-helper cell differentiation (GO:0042093)3.56847242
32cellular response to nicotine (GO:0071316)3.56158263
33interferon-gamma production (GO:0032609)3.53560300
34negative regulation of interleukin-12 production (GO:0032695)3.51448232
35leukocyte aggregation (GO:0070486)3.51229038
36regulation of immunoglobulin secretion (GO:0051023)3.50477131
37branching involved in labyrinthine layer morphogenesis (GO:0060670)3.40811660
38positive regulation of chemokine biosynthetic process (GO:0045080)3.37295756
39regulation of regulatory T cell differentiation (GO:0045589)3.36728993
40positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.36348027
41regulation of alpha-beta T cell proliferation (GO:0046640)3.34520444
42response to peptidoglycan (GO:0032494)3.31527535
43tyrosine phosphorylation of STAT protein (GO:0007260)3.31431638
44cellular response to interleukin-15 (GO:0071350)3.31241284
45regulation of isotype switching (GO:0045191)3.30536526
46positive regulation of natural killer cell differentiation (GO:0032825)3.30403321
47JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.26860464
48T cell selection (GO:0045058)3.25535116
49defense response to protozoan (GO:0042832)3.25499645
50positive regulation of interleukin-17 production (GO:0032740)3.23303064
51positive regulation of B cell mediated immunity (GO:0002714)3.21447089
52positive regulation of immunoglobulin mediated immune response (GO:0002891)3.21447089
53regulation of T-helper cell differentiation (GO:0045622)3.21288956
54myeloid dendritic cell activation (GO:0001773)3.18812003
55thymic T cell selection (GO:0045061)3.16103511
56T cell migration (GO:0072678)3.15989047
57positive regulation of isotype switching (GO:0045830)3.15460007
58regulation of interleukin-2 production (GO:0032663)3.13954808
59negative regulation of cytokine production involved in immune response (GO:0002719)3.09219803
60mast cell activation (GO:0045576)3.07235486
61regulation of chronic inflammatory response (GO:0002676)3.07078594
62response to protozoan (GO:0001562)3.05319777
63positive regulation of alpha-beta T cell proliferation (GO:0046641)3.05319141
64negative regulation of T cell mediated immunity (GO:0002710)3.04742852
65positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.03747032
66tolerance induction (GO:0002507)3.03311722
67alpha-beta T cell differentiation involved in immune response (GO:0002293)3.02050003
68alpha-beta T cell activation involved in immune response (GO:0002287)3.02050003
69T cell differentiation involved in immune response (GO:0002292)3.02050003
70lipopolysaccharide-mediated signaling pathway (GO:0031663)2.99911594
71germinal center formation (GO:0002467)2.97306431
72regulation of immunoglobulin production (GO:0002637)2.96579344
73positive regulation of B cell proliferation (GO:0030890)2.96041453
74regulation of chemokine biosynthetic process (GO:0045073)2.95273377
75cellular response to exogenous dsRNA (GO:0071360)2.95216716
76regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.94456147
77positive regulation of interleukin-10 production (GO:0032733)2.94249474
78response to muramyl dipeptide (GO:0032495)2.94181266
79NIK/NF-kappaB signaling (GO:0038061)2.92749019
80regulation of germinal center formation (GO:0002634)2.89572349
81regulation of B cell receptor signaling pathway (GO:0050855)2.87133911
82positive regulation of heat generation (GO:0031652)2.84744228
83positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84440760
84T cell lineage commitment (GO:0002360)2.83592952
85CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.82709352
86negative regulation of monooxygenase activity (GO:0032769)2.82154720
87regulation of interleukin-17 production (GO:0032660)2.81142196
88macrophage activation involved in immune response (GO:0002281)2.81006022
89interferon-gamma-mediated signaling pathway (GO:0060333)2.80569626
90regulation of T-helper 1 cell differentiation (GO:0045625)2.80460849
91regulation of T cell cytokine production (GO:0002724)2.80113487
92T-helper 1 type immune response (GO:0042088)2.79894464
93T cell receptor signaling pathway (GO:0050852)2.78601837
94positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.78250094
95regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.76876594
96regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.76642740
97positive regulation of immunoglobulin production (GO:0002639)2.76056445
98positive regulation of DNA recombination (GO:0045911)2.76039595
99modulation by symbiont of host cellular process (GO:0044068)2.75079337
100positive regulation of cytokine biosynthetic process (GO:0042108)2.74750229
101activation of MAPKKK activity (GO:0000185)2.74385837
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.73234654
103positive regulation of B cell activation (GO:0050871)2.72998693
104regulation of interleukin-12 production (GO:0032655)2.72355121
105antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.70948161
106positive regulation of defense response to virus by host (GO:0002230)2.70162519
107negative regulation of T-helper cell differentiation (GO:0045623)2.70035692
108negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.70035692
109B cell homeostasis (GO:0001782)2.69135592
110antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.68901294
111response to host immune response (GO:0052572)2.68671616
112response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.68671616
113T cell proliferation (GO:0042098)2.67363542
114negative regulation of alpha-beta T cell activation (GO:0046636)2.65767720
115positive regulation of lymphocyte mediated immunity (GO:0002708)2.65446301
116positive regulation of natural killer cell mediated immunity (GO:0002717)2.64343063
117positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.64343063
118immunoglobulin mediated immune response (GO:0016064)2.64164027
119negative regulation of production of molecular mediator of immune response (GO:0002701)2.63894119
120T cell costimulation (GO:0031295)2.63585173
121T cell activation involved in immune response (GO:0002286)2.62917750
122mature B cell differentiation (GO:0002335)2.62738960
123positive regulation of granulocyte differentiation (GO:0030854)2.62597265
124regulation of memory T cell differentiation (GO:0043380)2.62397126
125regulation of immunoglobulin mediated immune response (GO:0002889)2.62208834
126regulation of fever generation (GO:0031620)2.61178941
127regulation of T cell tolerance induction (GO:0002664)2.59877538
128positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.59628297
129dendritic cell differentiation (GO:0097028)2.59417648
130lymphocyte costimulation (GO:0031294)2.58629800
131response to type I interferon (GO:0034340)2.56988225
132regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.56138567
133regulation of natural killer cell mediated immunity (GO:0002715)2.56138567
134cellular response to type I interferon (GO:0071357)2.55914570
135type I interferon signaling pathway (GO:0060337)2.55914570
136myeloid cell activation involved in immune response (GO:0002275)2.55492669
137positive regulation of interleukin-12 production (GO:0032735)2.55458515
138regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.54627021
139regulation of B cell mediated immunity (GO:0002712)2.54205572
140positive regulation of astrocyte differentiation (GO:0048711)2.52518858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.41319514
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.78951670
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.64208143
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.50708877
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.01295018
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.99988476
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.97344146
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.86682809
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.74816843
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.54035670
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.41979412
12EZH2_22144423_ChIP-Seq_EOC_Human2.41914193
13* RUNX_20019798_ChIP-Seq_JUKART_Human2.41736045
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.29940893
15* VDR_21846776_ChIP-Seq_THP-1_Human2.25718184
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.24706526
17GBX2_23144817_ChIP-Seq_PC3_Human2.22573593
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21385981
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06494931
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.99684941
21IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97384804
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93840436
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93705594
24AR_21572438_ChIP-Seq_LNCaP_Human1.88429954
25* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85367461
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.77108362
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67938866
28* DROSHA_22980978_ChIP-Seq_HELA_Human1.66699349
29MYC_22102868_ChIP-Seq_BL_Human1.60752636
30MYB_26560356_Chip-Seq_TH2_Human1.60371516
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57825033
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.52855990
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.50287545
34NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.49612795
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48850464
36* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48323979
37* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46885931
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46664607
39* SPI1_23127762_ChIP-Seq_K562_Human1.45834024
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.45785241
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44519337
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43825879
43* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41002145
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37985849
45* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36579562
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35909985
47* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35499928
48SPI1_23547873_ChIP-Seq_NB4_Human1.34636179
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32379987
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31453388
51MYB_26560356_Chip-Seq_TH1_Human1.28864115
52* MAF_26560356_Chip-Seq_TH1_Human1.28136791
53* REST_21632747_ChIP-Seq_MESCs_Mouse1.26564887
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.25808996
55* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25433361
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24240236
57* PRDM14_20953172_ChIP-Seq_ESCs_Human1.22618887
58* GATA3_27048872_Chip-Seq_THYMUS_Human1.21777818
59* VDR_24787735_ChIP-Seq_THP-1_Human1.21729429
60* VDR_24763502_ChIP-Seq_THP-1_Human1.21270974
61KDM2B_26808549_Chip-Seq_DND41_Human1.20323245
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20106180
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19138351
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18808450
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.18003140
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.17748329
67TAF15_26573619_Chip-Seq_HEK293_Human1.16314184
68* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14252929
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13565434
70LXR_22292898_ChIP-Seq_THP-1_Human1.13469374
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12864926
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12633781
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.12407552
74* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12324194
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09708878
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08414785
77TP53_16413492_ChIP-PET_HCT116_Human1.08087830
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07672553
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06035739
80TCF7_22412390_ChIP-Seq_EML_Mouse1.05991794
81PU_27001747_Chip-Seq_BMDM_Mouse1.04032700
82* SMAD4_21799915_ChIP-Seq_A2780_Human1.03476824
83* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02993624
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.02916320
85* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02636587
86RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02542894
87EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02542894
88* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02117993
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01774471
90GATA1_22025678_ChIP-Seq_K562_Human1.01744764
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00447106
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99945301
93NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98709213
94UTX_26944678_Chip-Seq_JUKART_Human0.98221164
95JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98168648
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98021093
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94256270
98ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93774397
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93086316
100* KDM2B_26808549_Chip-Seq_JURKAT_Human0.92829595
101SCL_19346495_ChIP-Seq_HPC-7_Human0.91189273
102* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91030613
103* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90818309
104* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90542897
105EZH2_27294783_Chip-Seq_ESCs_Mouse0.90457303
106SMRT_27268052_Chip-Seq_Bcells_Human0.90192732
107* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89628278
108RXR_22108803_ChIP-Seq_LS180_Human0.89371107
109* KDM2B_26808549_Chip-Seq_K562_Human0.89286689
110* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88751482
111* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87904104
112* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86760268
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86750815
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85048545
115RUNX1_22412390_ChIP-Seq_EML_Mouse0.84146018
116GATA1_19941826_ChIP-Seq_K562_Human0.82826472
117SOX2_21211035_ChIP-Seq_LN229_Gbm0.82422806
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82240515
119TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81828993
120* MAF_26560356_Chip-Seq_TH2_Human0.81784759
121P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81758369
122P300_19829295_ChIP-Seq_ESCs_Human0.81716604
123SMAD3_21741376_ChIP-Seq_EPCs_Human0.81699208
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81656260
125ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.81492145
126STAT1_20625510_ChIP-Seq_HELA_Human0.81015904
127AHR_22903824_ChIP-Seq_MCF-7_Human0.80114594
128* STAT3_23295773_ChIP-Seq_U87_Human0.79912735
129* GATA3_26560356_Chip-Seq_TH2_Human0.79627707
130* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79298720
131VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79185009
132* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78766356
133GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76067094
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75812026
135PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71310525
136CTCF_27219007_Chip-Seq_ERYTHROID_Human0.70868661
137GATA2_22383799_ChIP-Seq_G1ME_Mouse0.70739305
138TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.70485416
139BCL6_27268052_Chip-Seq_Bcells_Human0.70041940
140BCOR_27268052_Chip-Seq_Bcells_Human0.64522357
141* MITF_21258399_ChIP-Seq_MELANOMA_Human0.64507224

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.14771984
2MP0004510_myositis3.38451278
3MP0003436_decreased_susceptibility_to3.21030467
4MP0004859_abnormal_synaptic_plasticity3.14952420
5MP0005387_immune_system_phenotype3.09917053
6MP0001790_abnormal_immune_system3.09917053
7MP0005671_abnormal_response_to2.86966752
8MP0005000_abnormal_immune_tolerance2.81478173
9MP0001835_abnormal_antigen_presentation2.71721156
10MP0003763_abnormal_thymus_physiology2.67754535
11MP0000685_abnormal_immune_system2.66082765
12MP0001800_abnormal_humoral_immune2.54364967
13MP0009785_altered_susceptibility_to2.46936060
14MP0003300_gastrointestinal_ulcer2.45641841
15MP0006082_CNS_inflammation2.38345332
16* MP0002723_abnormal_immune_serum2.29481850
17MP0002148_abnormal_hypersensitivity_rea2.25102891
18MP0002452_abnormal_antigen_presenting2.20143440
19MP0003724_increased_susceptibility_to2.19377886
20MP0001501_abnormal_sleep_pattern2.19311005
21MP0003866_abnormal_defecation2.15408157
22MP0005025_abnormal_response_to2.12604578
23MP0002405_respiratory_system_inflammati2.07167753
24MP0002419_abnormal_innate_immunity2.01863826
25MP0009278_abnormal_bone_marrow2.01620000
26MP0002420_abnormal_adaptive_immunity2.01461000
27MP0001819_abnormal_immune_cell2.00597750
28MP0002138_abnormal_hepatobiliary_system1.95932047
29MP0003880_abnormal_central_pattern1.86897100
30MP0005058_abnormal_lysosome_morphology1.78979887
31MP0003635_abnormal_synaptic_transmissio1.76567890
32MP0002006_tumorigenesis1.70043750
33* MP0002398_abnormal_bone_marrow1.69261454
34MP0002933_joint_inflammation1.66250631
35MP0000604_amyloidosis1.63171931
36MP0005310_abnormal_salivary_gland1.59983774
37MP0001533_abnormal_skeleton_physiology1.55760148
38* MP0000716_abnormal_immune_system1.55156465
39MP0009745_abnormal_behavioral_response1.51006421
40MP0010155_abnormal_intestine_physiology1.49434957
41MP0002064_seizures1.48589419
42MP0001853_heart_inflammation1.48194119
43MP0009840_abnormal_foam_cell1.45684238
44MP0002166_altered_tumor_susceptibility1.45573581
45MP0009333_abnormal_splenocyte_physiolog1.44073327
46MP0002063_abnormal_learning/memory/cond1.43191076
47MP0004381_abnormal_hair_follicle1.41657116
48MP0003172_abnormal_lysosome_physiology1.41082255
49MP0002735_abnormal_chemical_nociception1.39697448
50MP0000703_abnormal_thymus_morphology1.39483355
51MP0004947_skin_inflammation1.35822192
52MP0004742_abnormal_vestibular_system1.35295918
53MP0002396_abnormal_hematopoietic_system1.33948918
54MP0008961_abnormal_basal_metabolism1.33673514
55MP0001845_abnormal_inflammatory_respons1.32151941
56MP0002254_reproductive_system_inflammat1.28382517
57MP0004270_analgesia1.28343224
58MP0001968_abnormal_touch/_nociception1.28229681
59MP0000569_abnormal_digit_pigmentation1.27908108
60MP0001873_stomach_inflammation1.26797050
61MP0001545_abnormal_hematopoietic_system1.23370335
62MP0005397_hematopoietic_system_phenotyp1.23370335
63MP0000689_abnormal_spleen_morphology1.22769379
64MP0009046_muscle_twitch1.22282305
65MP0005464_abnormal_platelet_physiology1.22156101
66MP0008569_lethality_at_weaning1.20470409
67MP0001851_eye_inflammation1.20086928
68MP0003075_altered_response_to1.19697614
69MP0002722_abnormal_immune_system1.18035360
70MP0003453_abnormal_keratinocyte_physiol1.15149551
71MP0002572_abnormal_emotion/affect_behav1.14407248
72MP0000343_altered_response_to1.12621381
73MP0005167_abnormal_blood-brain_barrier1.11442220
74MP0002736_abnormal_nociception_after1.10614345
75* MP0002429_abnormal_blood_cell1.10365574
76* MP0002998_abnormal_bone_remodeling1.10344228
77MP0005451_abnormal_body_composition1.09602287
78MP0005645_abnormal_hypothalamus_physiol1.09038513
79MP0001486_abnormal_startle_reflex1.08519439
80MP0002272_abnormal_nervous_system1.06166525
81MP0002139_abnormal_hepatobiliary_system1.05908917
82MP0002332_abnormal_exercise_endurance1.05764842
83MP0000858_altered_metastatic_potential1.00792832
84MP0003329_amyloid_beta_deposits1.00471416
85MP0001440_abnormal_grooming_behavior0.99572444
86MP0003045_fibrosis0.95924910
87MP0000920_abnormal_myelination0.95910672
88MP0000465_gastrointestinal_hemorrhage0.94959152
89MP0005423_abnormal_somatic_nervous0.91039340
90MP0003633_abnormal_nervous_system0.90552037
91MP0003091_abnormal_cell_migration0.90060651
92MP0004808_abnormal_hematopoietic_stem0.89612255
93MP0004858_abnormal_nervous_system0.89508626
94MP0001970_abnormal_pain_threshold0.88716638
95MP0003448_altered_tumor_morphology0.88313129
96MP0003183_abnormal_peptide_metabolism0.88208440
97MP0003828_pulmonary_edema0.86648605
98MP0000015_abnormal_ear_pigmentation0.86549949
99MP0005166_decreased_susceptibility_to0.86207342
100MP0003690_abnormal_glial_cell0.86163513
101MP0002734_abnormal_mechanical_nocicepti0.86097841
102MP0002733_abnormal_thermal_nociception0.85565306
103MP0009764_decreased_sensitivity_to0.84233844
104MP0002067_abnormal_sensory_capabilities0.83802224
105MP0005076_abnormal_cell_differentiation0.83115487
106MP0001502_abnormal_circadian_rhythm0.80277289
107MP0005670_abnormal_white_adipose0.79227250
108MP0003195_calcinosis0.77593192
109MP0002693_abnormal_pancreas_physiology0.73985064
110MP0008057_abnormal_DNA_replication0.73625747
111MP0008469_abnormal_protein_level0.73544170
112MP0001663_abnormal_digestive_system0.72276694
113MP0009765_abnormal_xenobiotic_induced0.71960266
114MP0009780_abnormal_chondrocyte_physiolo0.70334565
115MP0002184_abnormal_innervation0.69969628
116MP0004811_abnormal_neuron_physiology0.69449251
117MP0005647_abnormal_sex_gland0.67726392
118MP0001881_abnormal_mammary_gland0.66301056
119MP0000371_diluted_coat_color0.65917616
120MP0005535_abnormal_body_temperature0.64946560
121MP0009763_increased_sensitivity_to0.63683903
122MP0005390_skeleton_phenotype0.63517578
123MP0002909_abnormal_adrenal_gland0.63327431
124MP0003631_nervous_system_phenotype0.63281257
125MP0005164_abnormal_response_to0.61065772
126MP0001348_abnormal_lacrimal_gland0.59413869
127MP0003950_abnormal_plasma_membrane0.59179105
128MP0002132_abnormal_respiratory_system0.59142547
129MP0003646_muscle_fatigue0.58862857
130MP0009115_abnormal_fat_cell0.54869042
131MP0005381_digestive/alimentary_phenotyp0.54633917
132MP0008004_abnormal_stomach_pH0.54569176
133MP0004883_abnormal_blood_vessel0.54191715
134MP0003879_abnormal_hair_cell0.54122812
135MP0000249_abnormal_blood_vessel0.53961390
136MP0005075_abnormal_melanosome_morpholog0.53642397

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.82177321
2Eczematoid dermatitis (HP:0000976)5.75517590
3Abnormality of glycolipid metabolism (HP:0010969)4.76162907
4Abnormality of liposaccharide metabolism (HP:0010968)4.76162907
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.76162907
6Recurrent fungal infections (HP:0002841)4.47163192
7Mediastinal lymphadenopathy (HP:0100721)4.01797569
8Panhypogammaglobulinemia (HP:0003139)3.99002760
9Vacuolated lymphocytes (HP:0001922)3.89081379
10Recurrent cutaneous fungal infections (HP:0011370)3.88283296
11Chronic mucocutaneous candidiasis (HP:0002728)3.88283296
12T lymphocytopenia (HP:0005403)3.78227509
13Elevated erythrocyte sedimentation rate (HP:0003565)3.77988120
14Recurrent viral infections (HP:0004429)3.71973001
15Abnormality of T cell number (HP:0011839)3.70496637
16Dysostosis multiplex (HP:0000943)3.52121774
17Focal motor seizures (HP:0011153)3.40932149
18Recurrent abscess formation (HP:0002722)3.40484529
19Severe combined immunodeficiency (HP:0004430)3.16244550
20Recurrent bacterial skin infections (HP:0005406)3.06444817
21Abnormality of binocular vision (HP:0011514)2.98149018
22Diplopia (HP:0000651)2.98149018
23Mutism (HP:0002300)2.94391232
24Chronic diarrhea (HP:0002028)2.91088763
25Abnormality of mucopolysaccharide metabolism (HP:0011020)2.90564378
26Abnormality of polysaccharide metabolism (HP:0011012)2.90564378
27Abnormality of glycosaminoglycan metabolism (HP:0004371)2.90564378
28Recurrent skin infections (HP:0001581)2.85199606
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.81097656
30Systemic lupus erythematosus (HP:0002725)2.77285381
31Increased IgM level (HP:0003496)2.75725094
32Vasculitis (HP:0002633)2.75137131
33Obstructive sleep apnea (HP:0002870)2.73566232
34Pulmonary infiltrates (HP:0002113)2.72978672
35Mucopolysacchariduria (HP:0008155)2.70809980
36Urinary glycosaminoglycan excretion (HP:0003541)2.70809980
37Loss of speech (HP:0002371)2.65468121
38Focal seizures (HP:0007359)2.61961109
39Abnormality of T cells (HP:0002843)2.60215624
40Gingivitis (HP:0000230)2.50374450
41Obstructive lung disease (HP:0006536)2.47347938
42Chronic obstructive pulmonary disease (HP:0006510)2.47347938
43Combined immunodeficiency (HP:0005387)2.46990757
44Optic neuritis (HP:0100653)2.46918201
45Retrobulbar optic neuritis (HP:0100654)2.46918201
46Gastrointestinal infarctions (HP:0005244)2.45496638
47Abnormality of the columella (HP:0009929)2.37741496
48Persistence of primary teeth (HP:0006335)2.37382870
49Abnormality of macrophages (HP:0004311)2.33552850
50Basal ganglia calcification (HP:0002135)2.33408430
51Autoimmune hemolytic anemia (HP:0001890)2.32406975
52B lymphocytopenia (HP:0010976)2.31845898
53Abnormality of B cell number (HP:0010975)2.31845898
54Chronic otitis media (HP:0000389)2.31137792
55Interstitial pulmonary disease (HP:0006530)2.29552221
56Fatigue (HP:0012378)2.28082090
57Restrictive lung disease (HP:0002091)2.28033035
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.27101809
59Myositis (HP:0100614)2.25915584
60Clumsiness (HP:0002312)2.24973604
61Visual hallucinations (HP:0002367)2.24864140
62Spondylolisthesis (HP:0003302)2.23259541
63Encephalitis (HP:0002383)2.21023871
64Neuronal loss in central nervous system (HP:0002529)2.20202009
65Arterial thrombosis (HP:0004420)2.19661291
66Abnormality of the fingertips (HP:0001211)2.19079976
67IgA deficiency (HP:0002720)2.18782243
68Hypoplasia of the thymus (HP:0000778)2.18350156
69Increased density of long bones (HP:0006392)2.17047255
70Autoimmune thrombocytopenia (HP:0001973)2.15933361
71Cheilitis (HP:0100825)2.15651383
72Emphysema (HP:0002097)2.15597750
73Keratoconjunctivitis sicca (HP:0001097)2.15253749
74Urethral obstruction (HP:0000796)2.14933907
75Truncal ataxia (HP:0002078)2.14403898
76Cerebral inclusion bodies (HP:0100314)2.14205081
77Febrile seizures (HP:0002373)2.14082130
78Gastrointestinal stroma tumor (HP:0100723)2.14045289
79Recurrent gram-negative bacterial infections (HP:0005420)2.13860360
80Pustule (HP:0200039)2.12621474
81Premature loss of primary teeth (HP:0006323)2.12297689
82Abnormality of the nasal mucosa (HP:0000433)2.12056057
83Supranuclear gaze palsy (HP:0000605)2.11266369
84Nuclear cataract (HP:0100018)2.10651808
85Hemoptysis (HP:0002105)2.10019377
86Colitis (HP:0002583)2.09275146
87Epileptic encephalopathy (HP:0200134)2.08203955
88Short 1st metacarpal (HP:0010034)2.07495573
89Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.07495573
90Periodontitis (HP:0000704)2.06899881
91Meningitis (HP:0001287)2.06243038
92Keratoconjunctivitis (HP:0001096)2.05958239
93Inflammation of the large intestine (HP:0002037)2.05625096
94Leukocytosis (HP:0001974)2.04254366
95IgG deficiency (HP:0004315)2.03787013
96Chest pain (HP:0100749)2.01638081
97Hypergammaglobulinemia (HP:0010702)2.01630142
98Increased serum ferritin (HP:0003281)2.00720352
99Abnormality of the pleura (HP:0002103)2.00328460
100Joint swelling (HP:0001386)1.99935655
101Orchitis (HP:0100796)1.99760479
102Progressive inability to walk (HP:0002505)1.99080359
103Recurrent bronchitis (HP:0002837)1.99012920
104Nasal polyposis (HP:0100582)1.99007091
105Increased neuronal autofluorescent lipopigment (HP:0002074)1.98481331
106Hematochezia (HP:0002573)1.98468147
107Increased IgE level (HP:0003212)1.97779087
108Gastrointestinal inflammation (HP:0004386)1.97737327
109Increased cerebral lipofuscin (HP:0011813)1.96528399
110Myocardial infarction (HP:0001658)1.94866394
111Impaired smooth pursuit (HP:0007772)1.94229777
112Absence seizures (HP:0002121)1.94120456
113Inappropriate behavior (HP:0000719)1.93287305
114Spontaneous hematomas (HP:0007420)1.93187582
115Apathy (HP:0000741)1.92631411
116Agammaglobulinemia (HP:0004432)1.92592592
117Parakeratosis (HP:0001036)1.92315847
118Dysmetria (HP:0001310)1.92270334
119Progressive cerebellar ataxia (HP:0002073)1.91240574
120Abnormality of T cell physiology (HP:0011840)1.90499404
121Cellulitis (HP:0100658)1.88770563
122Abnormal hair whorl (HP:0010721)1.88170421
123Axonal loss (HP:0003447)1.87844414
124Lymphopenia (HP:0001888)1.87550855
125Acrocyanosis (HP:0001063)1.84645265
126Slow saccadic eye movements (HP:0000514)1.81954721
127Arthralgia (HP:0002829)1.81364671
128Peripheral hypomyelination (HP:0007182)1.80356870
129Porencephaly (HP:0002132)1.80230048
130Abnormality of cells of the lymphoid lineage (HP:0012140)1.80117020
131Eosinophilia (HP:0001880)1.79973894
132Thyroiditis (HP:0100646)1.79729817
133Dialeptic seizures (HP:0011146)1.78147826
134Genetic anticipation (HP:0003743)1.77902388
135Oligodontia (HP:0000677)1.75307362
136Absent frontal sinuses (HP:0002688)1.74434185
137Disinhibition (HP:0000734)1.74018525
138Myokymia (HP:0002411)1.73957595
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73138359
140Macroorchidism (HP:0000053)1.73006996
141Abnormality of eosinophils (HP:0001879)1.72717255
142Stereotypic behavior (HP:0000733)1.72700230
143Neurofibrillary tangles (HP:0002185)1.72482940
144Diminished motivation (HP:0000745)1.71553085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.25986211
2TXK3.99525490
3RIPK43.79357363
4MAP3K143.45021613
5JAK33.35614540
6ZAP702.60069991
7SIK22.25488340
8MAP3K132.13883423
9TAOK12.00626178
10GRK71.95841530
11CDC42BPA1.88713030
12FES1.74068521
13ERN11.71390351
14IKBKB1.69711307
15ADRBK21.60033437
16TYK21.59531940
17IKBKE1.59219573
18CHUK1.57901672
19NTRK31.57885735
20NTRK21.56534053
21NME21.54107749
22SYK1.50519968
23HCK1.48499998
24JAK11.48356523
25BLK1.47115766
26SIK31.44196776
27TBK11.41543500
28LCK1.37811225
29MATK1.36986717
30MAP3K71.35308185
31CAMK1G1.34877980
32DDR21.32025855
33EPHB11.30270472
34DAPK21.26747999
35PRKCH1.26553054
36CSK1.25925284
37EPHA41.22801875
38IRAK31.20839926
39ITK1.19257954
40MAP3K91.18671391
41CDK121.17600619
42TAOK21.17103373
43TGFBR21.16832381
44TAOK31.15307532
45MAPK71.08085545
46BMPR21.08064083
47TYRO31.07660054
48FGR1.06262948
49EPHA31.03339649
50MAP3K111.02623080
51FGFR31.01944816
52PIM21.00952822
53MAP3K11.00372349
54MARK20.99118425
55PRKCQ0.98939478
56MAPK120.98930092
57KIT0.98381235
58MOS0.97324835
59CLK10.96710642
60ALK0.86860096
61LYN0.85909392
62TEC0.85451416
63JAK20.81351021
64CDK90.81018486
65EEF2K0.80885975
66IRAK40.80562265
67SGK30.80406630
68DMPK0.80211339
69PRKD20.79477776
70NME10.78023181
71FRK0.75898911
72CDK40.75531519
73PRPF4B0.74773454
74CAMKK10.73033626
75CAMK1D0.72138963
76RAF10.69021613
77PDGFRB0.67716139
78FGFR40.67088051
79SMG10.66340043
80PDK10.64864750
81HIPK20.64266462
82CAMK10.63801072
83MAPKAPK50.63023961
84MAPK40.62252125
85MAPK110.60349729
86MAP3K30.59927971
87DAPK10.59451738
88CAMKK20.58992732
89BTK0.58375544
90ICK0.56916680
91FYN0.56600755
92TNK20.56421838
93TNIK0.56417751
94NLK0.56198732
95SGK20.55850475
96TRIB30.55387618
97NEK90.54880679
98EGFR0.52812984
99PRKD30.52772369
100PNCK0.52768479
101CDK50.52135785
102TRPM70.52113076
103MAP2K70.51857000
104MARK30.51689605
105ROCK20.51340118
106MAP3K40.50188114
107PKN10.50109978
108MAP3K50.49700893
109MAPKAPK30.48684040
110ACVR1B0.47835924
111PLK20.47121782
112MINK10.45581443
113MARK10.44072320
114MELK0.43959003
115PAK60.43556423
116RIPK10.43245531
117INSR0.43226433
118KSR20.43220824
119MAP2K60.43049240
120STK100.42693359
121BRD40.42336579
122SGK10.42134241
123PRKCG0.42099759
124SIK10.41877336
125IRAK10.40069241
126CSF1R0.39775296
127MAP2K30.39575593
128SGK2230.39399805
129SGK4940.39399805
130MAP3K100.38584189
131TSSK60.38421957
132MAPKAPK20.37353659
133CASK0.36806138
134MAPK30.35363407
135PTK2B0.34506386
136PRKAA20.34432797
137CAMK40.33939112

Predicted pathways (KEGG)

RankGene SetZ-score
1Type I diabetes mellitus_Homo sapiens_hsa049402.47947608
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.41457777
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.32388990
4T cell receptor signaling pathway_Homo sapiens_hsa046602.24330206
5Graft-versus-host disease_Homo sapiens_hsa053322.15087222
6Allograft rejection_Homo sapiens_hsa053302.14334153
7Primary immunodeficiency_Homo sapiens_hsa053402.09259205
8Leishmaniasis_Homo sapiens_hsa051402.07640242
9Osteoclast differentiation_Homo sapiens_hsa043801.89078002
10Measles_Homo sapiens_hsa051621.82107538
11Other glycan degradation_Homo sapiens_hsa005111.77047147
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75253668
13Asthma_Homo sapiens_hsa053101.69004402
14B cell receptor signaling pathway_Homo sapiens_hsa046621.63394576
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61689538
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60938723
17Rheumatoid arthritis_Homo sapiens_hsa053231.50845900
18TNF signaling pathway_Homo sapiens_hsa046681.50287751
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45237273
20Lysosome_Homo sapiens_hsa041421.42951838
21Tuberculosis_Homo sapiens_hsa051521.40301925
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36065919
23Chemokine signaling pathway_Homo sapiens_hsa040621.35375279
24Autoimmune thyroid disease_Homo sapiens_hsa053201.29771031
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.29510345
26Nicotine addiction_Homo sapiens_hsa050331.27316347
27Hematopoietic cell lineage_Homo sapiens_hsa046401.25178491
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24581323
29Pertussis_Homo sapiens_hsa051331.23791847
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23494087
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.21492137
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21203932
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20017456
34Legionellosis_Homo sapiens_hsa051341.19837003
35African trypanosomiasis_Homo sapiens_hsa051431.19780184
36Influenza A_Homo sapiens_hsa051641.16641059
37Prolactin signaling pathway_Homo sapiens_hsa049171.16519366
38Acute myeloid leukemia_Homo sapiens_hsa052211.16121404
39Malaria_Homo sapiens_hsa051441.15549678
40Long-term potentiation_Homo sapiens_hsa047201.15026925
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.13938733
42Synaptic vesicle cycle_Homo sapiens_hsa047211.13788314
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13433890
44Toxoplasmosis_Homo sapiens_hsa051451.13217542
45Type II diabetes mellitus_Homo sapiens_hsa049301.11058793
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10393345
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09714797
48Salmonella infection_Homo sapiens_hsa051321.06954698
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04853323
50Glutamatergic synapse_Homo sapiens_hsa047241.03936022
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02694589
52Morphine addiction_Homo sapiens_hsa050321.00724344
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99798553
54Hepatitis B_Homo sapiens_hsa051610.98867750
55Circadian entrainment_Homo sapiens_hsa047130.98464367
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.98457775
57Olfactory transduction_Homo sapiens_hsa047400.94415484
58Cholinergic synapse_Homo sapiens_hsa047250.93711934
59Chronic myeloid leukemia_Homo sapiens_hsa052200.93305740
60Salivary secretion_Homo sapiens_hsa049700.91850932
61Cocaine addiction_Homo sapiens_hsa050300.90187828
62MAPK signaling pathway_Homo sapiens_hsa040100.86957973
63Herpes simplex infection_Homo sapiens_hsa051680.86939896
64Shigellosis_Homo sapiens_hsa051310.86177089
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85805749
66GABAergic synapse_Homo sapiens_hsa047270.82542986
67Insulin secretion_Homo sapiens_hsa049110.81464706
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81440702
69Dorso-ventral axis formation_Homo sapiens_hsa043200.79979794
70Collecting duct acid secretion_Homo sapiens_hsa049660.79367881
71Epstein-Barr virus infection_Homo sapiens_hsa051690.78821982
72ErbB signaling pathway_Homo sapiens_hsa040120.78659726
73Viral myocarditis_Homo sapiens_hsa054160.78181554
74Long-term depression_Homo sapiens_hsa047300.78065839
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77942647
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.77691279
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77508437
78Amphetamine addiction_Homo sapiens_hsa050310.77010930
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76522778
80Hepatitis C_Homo sapiens_hsa051600.76221118
81Dopaminergic synapse_Homo sapiens_hsa047280.75130957
82Pancreatic cancer_Homo sapiens_hsa052120.74002313
83Gastric acid secretion_Homo sapiens_hsa049710.70078883
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70024649
85Renin secretion_Homo sapiens_hsa049240.69926430
86cAMP signaling pathway_Homo sapiens_hsa040240.69060169
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69020881
88VEGF signaling pathway_Homo sapiens_hsa043700.68895874
89Renal cell carcinoma_Homo sapiens_hsa052110.67037465
90Oxytocin signaling pathway_Homo sapiens_hsa049210.66608755
91Serotonergic synapse_Homo sapiens_hsa047260.65601170
92Glioma_Homo sapiens_hsa052140.65086713
93Prion diseases_Homo sapiens_hsa050200.64210158
94GnRH signaling pathway_Homo sapiens_hsa049120.63667800
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62066039
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59814810
97HTLV-I infection_Homo sapiens_hsa051660.58868635
98Notch signaling pathway_Homo sapiens_hsa043300.58460328
99Apoptosis_Homo sapiens_hsa042100.58324365
100Phagosome_Homo sapiens_hsa041450.58293123
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57620226
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.57012287
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.56572134
104Insulin resistance_Homo sapiens_hsa049310.56402387
105Staphylococcus aureus infection_Homo sapiens_hsa051500.56130883
106Calcium signaling pathway_Homo sapiens_hsa040200.56037175
107Amoebiasis_Homo sapiens_hsa051460.52731057
108Platelet activation_Homo sapiens_hsa046110.51519992
109Estrogen signaling pathway_Homo sapiens_hsa049150.50783961
110Choline metabolism in cancer_Homo sapiens_hsa052310.49963797
111Antigen processing and presentation_Homo sapiens_hsa046120.49255299
112mTOR signaling pathway_Homo sapiens_hsa041500.48390373
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48273967
114Ras signaling pathway_Homo sapiens_hsa040140.48005113
115FoxO signaling pathway_Homo sapiens_hsa040680.42964942
116Viral carcinogenesis_Homo sapiens_hsa052030.42025808
117Non-small cell lung cancer_Homo sapiens_hsa052230.41594548
118Sphingolipid metabolism_Homo sapiens_hsa006000.40932601
119Bladder cancer_Homo sapiens_hsa052190.38179417
120Prostate cancer_Homo sapiens_hsa052150.32031172
121Rap1 signaling pathway_Homo sapiens_hsa040150.30036664

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