HIVEP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two widely separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a serine/threonine-rich sequence. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.78642339
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.73014322
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.54747982
4synaptic vesicle maturation (GO:0016188)5.50288365
5vocalization behavior (GO:0071625)5.10065565
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.09760637
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.03242385
8glutamate secretion (GO:0014047)4.88791080
9synaptic vesicle exocytosis (GO:0016079)4.87796859
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.76528693
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.72846446
12regulation of glutamate receptor signaling pathway (GO:1900449)4.71122847
13regulation of synaptic vesicle exocytosis (GO:2000300)4.58559907
14protein localization to synapse (GO:0035418)4.44605398
15exploration behavior (GO:0035640)4.32318146
16glutamate receptor signaling pathway (GO:0007215)4.26745282
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.22662681
18neuronal action potential propagation (GO:0019227)4.20273263
19regulation of neuronal synaptic plasticity (GO:0048168)4.15332989
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.14517627
21synaptic transmission, glutamatergic (GO:0035249)4.14260099
22regulation of synaptic vesicle transport (GO:1902803)4.10309335
23layer formation in cerebral cortex (GO:0021819)3.99719866
24positive regulation of gamma-delta T cell activation (GO:0046645)3.95530820
25negative regulation of cell killing (GO:0031342)3.94959778
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.94959778
27regulation of synapse structural plasticity (GO:0051823)3.94672833
28long-term memory (GO:0007616)3.92042575
29neurotransmitter-gated ion channel clustering (GO:0072578)3.91112324
30regulation of excitatory postsynaptic membrane potential (GO:0060079)3.88953270
31neurotransmitter secretion (GO:0007269)3.85368758
32cellular potassium ion homeostasis (GO:0030007)3.81121964
33neuron-neuron synaptic transmission (GO:0007270)3.80269669
34neuron cell-cell adhesion (GO:0007158)3.79924415
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76705662
36dendritic spine morphogenesis (GO:0060997)3.75762603
37regulation of dendritic spine morphogenesis (GO:0061001)3.73300089
38regulation of postsynaptic membrane potential (GO:0060078)3.67132601
39germinal center formation (GO:0002467)3.62530056
40sodium ion export (GO:0071436)3.62065029
41positive regulation of synapse maturation (GO:0090129)3.59245757
42positive regulation of membrane potential (GO:0045838)3.58614548
43regulation of synaptic plasticity (GO:0048167)3.55709835
44long-term synaptic potentiation (GO:0060291)3.47207916
45proline transport (GO:0015824)3.46067339
46cerebellar Purkinje cell differentiation (GO:0021702)3.45668046
47regulation of ARF protein signal transduction (GO:0032012)3.41444674
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.38284568
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.34780209
50G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.34178382
51activation of protein kinase A activity (GO:0034199)3.31198251
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28730473
53gamma-aminobutyric acid transport (GO:0015812)3.28192102
54positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.27020317
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.26133396
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.25242619
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.24779485
58regulation of dendritic spine development (GO:0060998)3.24158686
59regulation of neurotransmitter secretion (GO:0046928)3.19314493
60positive regulation of neurotransmitter secretion (GO:0001956)3.16624001
61neuromuscular process controlling balance (GO:0050885)3.16479308
62dendrite morphogenesis (GO:0048813)3.15361076
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14497289
64regulation of T-helper 2 cell differentiation (GO:0045628)3.13869703
65postsynaptic membrane organization (GO:0001941)3.12279228
66neuron recognition (GO:0008038)3.09659122
67membrane depolarization (GO:0051899)3.09438440
68synaptic vesicle endocytosis (GO:0048488)3.09367675
69membrane depolarization during action potential (GO:0086010)3.07198071
70cell communication by electrical coupling (GO:0010644)3.06389650
71positive regulation of dendritic spine morphogenesis (GO:0061003)3.06301059
72innervation (GO:0060384)3.05808329
73axonal fasciculation (GO:0007413)3.05550123
74regulation of B cell receptor signaling pathway (GO:0050855)3.05243805
75regulation of gamma-delta T cell activation (GO:0046643)3.04757537
76negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.03212182
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01066438
78chemosensory behavior (GO:0007635)3.00411878
79neurotransmitter transport (GO:0006836)2.97447923
80regulation of vesicle fusion (GO:0031338)2.95718822
81negative regulation of interleukin-12 production (GO:0032695)2.94765511
82long term synaptic depression (GO:0060292)2.94712206
83macrophage activation involved in immune response (GO:0002281)2.94116503
84response to histamine (GO:0034776)2.93623306
85positive regulation of dendritic spine development (GO:0060999)2.93054911
86dendritic spine organization (GO:0097061)2.92804969
87negative regulation of T cell mediated immunity (GO:0002710)2.92343452
88negative regulation of synaptic transmission, GABAergic (GO:0032229)2.92184782
89vesicle transport along microtubule (GO:0047496)2.92178540
90cerebellar granule cell differentiation (GO:0021707)2.91864507
91regulation of neurotransmitter transport (GO:0051588)2.90965851
92positive regulation of neurotransmitter transport (GO:0051590)2.90875367
93behavioral defense response (GO:0002209)2.89309025
94behavioral fear response (GO:0001662)2.89309025
95response to interleukin-15 (GO:0070672)2.89238648
96response to muramyl dipeptide (GO:0032495)2.88691389
97transmission of nerve impulse (GO:0019226)2.88650611
98antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.88022024
99positive regulation of synaptic transmission (GO:0050806)2.84774281
100positive T cell selection (GO:0043368)2.84753054
101learning (GO:0007612)2.84574934
102positive regulation of Rap GTPase activity (GO:0032854)2.83627665
103auditory behavior (GO:0031223)2.83605242
104regulation of T-helper 1 cell differentiation (GO:0045625)2.83096067
105negative T cell selection (GO:0043383)2.82087579
106negative thymic T cell selection (GO:0045060)2.81184557
107tolerance induction (GO:0002507)2.80579105
108regulation of synaptic transmission (GO:0050804)2.79817535
109presynaptic membrane assembly (GO:0097105)2.77088904
110regulation of vitamin D biosynthetic process (GO:0060556)2.76721118
111antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.76698835
112L-amino acid import (GO:0043092)2.76549573
113regulation of voltage-gated calcium channel activity (GO:1901385)2.76529274
114regulation of neurotransmitter levels (GO:0001505)2.76001446
115establishment of nucleus localization (GO:0040023)2.75816794
116positive regulation of synaptic transmission, GABAergic (GO:0032230)2.75483794
117regulation of NFAT protein import into nucleus (GO:0051532)2.75425050
118prepulse inhibition (GO:0060134)2.74773466
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.73571574
120fear response (GO:0042596)2.73093682
121regulation of gamma-delta T cell differentiation (GO:0045586)2.73059631
122cellular sodium ion homeostasis (GO:0006883)2.72200697
123regulation of interleukin-12 biosynthetic process (GO:0045075)2.72195721
124nerve growth factor signaling pathway (GO:0038180)2.72159006
125membrane hyperpolarization (GO:0060081)2.72089415
126response to auditory stimulus (GO:0010996)2.71897773
127positive regulation of fibroblast migration (GO:0010763)2.71701111
128detection of calcium ion (GO:0005513)2.71457206
129type I interferon signaling pathway (GO:0060337)2.70950044
130cellular response to type I interferon (GO:0071357)2.70950044
131response to type I interferon (GO:0034340)2.69840483
132positive thymic T cell selection (GO:0045059)2.68338466
133cellular response to ethanol (GO:0071361)2.68207528
134T cell selection (GO:0045058)2.65913430
135thymic T cell selection (GO:0045061)2.62216252
136leukocyte aggregation (GO:0070486)2.60907950
137cellular response to interleukin-15 (GO:0071350)2.60148626
138negative regulation of type 2 immune response (GO:0002829)2.59673086
139lipopolysaccharide-mediated signaling pathway (GO:0031663)2.57871984
140T cell migration (GO:0072678)2.57745014
141regulation of necroptotic process (GO:0060544)2.55570600
142regulation of Rap GTPase activity (GO:0032317)2.54737472
143signal complex assembly (GO:0007172)2.51684496
144B cell receptor signaling pathway (GO:0050853)2.49315859
145myeloid dendritic cell differentiation (GO:0043011)2.48221272
146NIK/NF-kappaB signaling (GO:0038061)2.47611199
147regulation of type 2 immune response (GO:0002828)2.46481954
148positive regulation of type 2 immune response (GO:0002830)2.43116872
149CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.42454682
150modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.42132245
151positive regulation by organism of defense response of other organism involved in symbiotic interact2.42132245
152modulation by symbiont of host immune response (GO:0052553)2.42132245
153positive regulation by symbiont of host defense response (GO:0052509)2.42132245
154modulation by symbiont of host defense response (GO:0052031)2.42132245
155modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.42132245
156antigen processing and presentation of endogenous antigen (GO:0019883)2.41981976
157regulation of T cell tolerance induction (GO:0002664)2.41130178
158response to peptidoglycan (GO:0032494)2.39370001
159positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.39092748
160negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.38646560
161negative regulation of T-helper cell differentiation (GO:0045623)2.38646560
162interferon-gamma-mediated signaling pathway (GO:0060333)2.35225459
163sarcoplasmic reticulum calcium ion transport (GO:0070296)2.33095374
164regulation of interleukin-2 biosynthetic process (GO:0045076)2.32155553
165positive regulation of tolerance induction (GO:0002645)2.29676953
166negative regulation of lymphocyte mediated immunity (GO:0002707)2.29612469
167negative regulation of erythrocyte differentiation (GO:0045647)2.29297325
168detection of molecule of bacterial origin (GO:0032490)2.28411946
169positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.27695679
170defense response to protozoan (GO:0042832)2.26654650
171CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.23001137
172T-helper cell differentiation (GO:0042093)2.23001137
173JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.22972519
174histone H3-K36 demethylation (GO:0070544)2.21670808
175negative regulation of toll-like receptor signaling pathway (GO:0034122)2.19057795
176regulation of tolerance induction (GO:0002643)2.17636371
177response to protozoan (GO:0001562)2.16813687
178regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.16767859
179positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.16112845
180protein localization to endosome (GO:0036010)2.15351175
181regulation of interferon-beta biosynthetic process (GO:0045357)2.14242322
182negative regulation of cytokine production involved in immune response (GO:0002719)2.12281969
183B cell proliferation (GO:0042100)2.12194344
184B cell homeostasis (GO:0001782)2.11323793
185positive regulation of interleukin-2 production (GO:0032743)2.11008189
186negative regulation of leukocyte mediated immunity (GO:0002704)2.10947722
187activation of MAPKKK activity (GO:0000185)2.09692337
188regulation of isotype switching to IgG isotypes (GO:0048302)2.09678500
189detection of other organism (GO:0098543)2.09102862
190regulation of chronic inflammatory response (GO:0002676)2.08349623
191response to nerve growth factor (GO:1990089)2.07861902
192cellular response to nerve growth factor stimulus (GO:1990090)2.07861902
193regulation of membrane protein ectodomain proteolysis (GO:0051043)2.07484170
194regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.06838086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67313580
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.66672003
3GBX2_23144817_ChIP-Seq_PC3_Human3.38397050
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.08914464
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.92485043
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85454372
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80064923
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76539297
9DROSHA_22980978_ChIP-Seq_HELA_Human2.65319121
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51770251
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51770251
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50514120
13RUNX_20019798_ChIP-Seq_JUKART_Human2.49495749
14* RARB_27405468_Chip-Seq_BRAIN_Mouse2.46723289
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45070519
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.37603013
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35204451
18* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.32750010
19REST_21632747_ChIP-Seq_MESCs_Mouse2.29234354
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28757051
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28100788
22* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25575865
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.14317257
24* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11933157
25* EZH2_27304074_Chip-Seq_ESCs_Mouse2.10520223
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.08137075
27AR_21572438_ChIP-Seq_LNCaP_Human2.07653284
28* RNF2_27304074_Chip-Seq_ESCs_Mouse2.04681958
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.00720890
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97538615
31* EZH2_27294783_Chip-Seq_ESCs_Mouse1.96964259
32* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96822948
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.94935350
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90958387
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89928067
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.89236587
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88484896
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.87762764
39* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86214450
40* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84754072
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81443965
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80678816
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.78353467
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75048047
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73109816
46* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67309676
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.62860959
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.61352375
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.60584406
50* TCF7_22412390_ChIP-Seq_EML_Mouse1.60298611
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.56982191
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54943023
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50483004
54VDR_24787735_ChIP-Seq_THP-1_Human1.47843632
55* KDM2B_26808549_Chip-Seq_DND41_Human1.47156440
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.46747080
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45702087
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43691439
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42121527
60* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41713464
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39633041
62SPI1_23127762_ChIP-Seq_K562_Human1.38492531
63* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37730096
64NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36781222
65TP53_16413492_ChIP-PET_HCT116_Human1.36537683
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35196267
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33054825
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30028350
69* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29649076
70* MYB_26560356_Chip-Seq_TH2_Human1.28927439
71* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28549823
72SCL_19346495_ChIP-Seq_HPC-7_Human1.28395561
73TAF15_26573619_Chip-Seq_HEK293_Human1.27967074
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.27367151
75AHR_22903824_ChIP-Seq_MCF-7_Human1.27293856
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26602601
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26338819
78* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26271565
79GATA1_22025678_ChIP-Seq_K562_Human1.25729065
80* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25705783
81AR_19668381_ChIP-Seq_PC3_Human1.24889765
82P300_19829295_ChIP-Seq_ESCs_Human1.24758597
83MAF_26560356_Chip-Seq_TH1_Human1.24152993
84* KDM2B_26808549_Chip-Seq_JURKAT_Human1.24146850
85STAT3_23295773_ChIP-Seq_U87_Human1.23957185
86AR_25329375_ChIP-Seq_VCAP_Human1.23654158
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.23485321
88* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21185571
89* KDM2B_26808549_Chip-Seq_K562_Human1.18731507
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.18381876
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17172436
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17052125
93* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15979778
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.15480324
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15237669
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.15175437
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15099862
98* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15002848
99* RING1B_27294783_Chip-Seq_ESCs_Mouse1.14681125
100* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14175810
101RXR_22108803_ChIP-Seq_LS180_Human1.13949437
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13543554
103* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12844282
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12585050
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12249233
106DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11231456
107TCF4_23295773_ChIP-Seq_U87_Human1.10907807
108ZNF274_21170338_ChIP-Seq_K562_Hela1.08681549
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08249021
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08054202
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07936071
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07883237
113* VDR_24763502_ChIP-Seq_THP-1_Human1.07805884
114FOXO3_23340844_ChIP-Seq_DLD1_Human1.07607053
115MYB_26560356_Chip-Seq_TH1_Human1.07516229
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07370388
117PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06698013
118GATA1_19941826_ChIP-Seq_K562_Human1.06573703
119* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06382639
120SMAD3_21741376_ChIP-Seq_HESCs_Human1.04379324
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04341303
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.03967735
123P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02222544
124* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01884112
125* MYC_22102868_ChIP-Seq_BL_Human1.01713263
126* RING1B_27294783_Chip-Seq_NPCs_Mouse1.01231255
127* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01107172
128CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00996646
129RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00780949
130NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00737034
131* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99843053
132* PU_27001747_Chip-Seq_BMDM_Mouse0.99112129
133TP53_18474530_ChIP-ChIP_U2OS_Human0.99020053
134* GATA3_27048872_Chip-Seq_THYMUS_Human0.98721323
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.98028837
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97737260
137GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97693548
138ESR1_20079471_ChIP-ChIP_T-47D_Human0.96847039
139NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96644399
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96220398
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95931006
142BCAT_22108803_ChIP-Seq_LS180_Human0.94727067
143GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94524072
144* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94221845
145TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93799546
146DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93697275
147SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93179123
148TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92764166
149POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92764166
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92071894
151RUNX1_22412390_ChIP-Seq_EML_Mouse0.91669943
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.91666335
153* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89838721
154SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89735923
155TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89714501
156* RUNX2_22187159_ChIP-Seq_PCA_Human0.89445143
157* TBX20_22080862_ChIP-Seq_HEART_Mouse0.89253642
158* TBX20_22328084_ChIP-Seq_HEART_Mouse0.89253642
159PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88521093
160GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88346245
161EP300_21415370_ChIP-Seq_HL-1_Mouse0.86576443
162GATA2_19941826_ChIP-Seq_K562_Human0.85500289
163CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85394479
164* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85269828
165* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85229746
166SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85156135
167* FOXA2_19822575_ChIP-Seq_HepG2_Human0.84484857
168* UTX_26944678_Chip-Seq_JUKART_Human0.83544702
169NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82788303
170MAF_26560356_Chip-Seq_TH2_Human0.80633551
171SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80534051
172SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80534051

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.44227148
2MP0003880_abnormal_central_pattern4.49617371
3MP0003635_abnormal_synaptic_transmissio4.35403403
4MP0004270_analgesia4.00794807
5MP0009745_abnormal_behavioral_response3.49875551
6MP0002063_abnormal_learning/memory/cond3.47103329
7MP0002064_seizures3.11330268
8MP0009046_muscle_twitch2.98647911
9MP0001968_abnormal_touch/_nociception2.89593991
10MP0003436_decreased_susceptibility_to2.89456500
11MP0003300_gastrointestinal_ulcer2.88960249
12MP0002572_abnormal_emotion/affect_behav2.80121306
13MP0003763_abnormal_thymus_physiology2.76526921
14MP0009780_abnormal_chondrocyte_physiolo2.73172893
15MP0002822_catalepsy2.72183538
16MP0003724_increased_susceptibility_to2.70636917
17MP0001486_abnormal_startle_reflex2.49387105
18MP0002734_abnormal_mechanical_nocicepti2.47467349
19MP0002272_abnormal_nervous_system2.45748869
20MP0001501_abnormal_sleep_pattern2.44050964
21MP0005423_abnormal_somatic_nervous2.36058082
22MP0005000_abnormal_immune_tolerance2.29286021
23MP0008569_lethality_at_weaning2.25076244
24MP0001790_abnormal_immune_system2.24456300
25MP0005387_immune_system_phenotype2.24456300
26MP0004947_skin_inflammation2.23895909
27MP0001835_abnormal_antigen_presentation2.18746518
28MP0001800_abnormal_humoral_immune2.12599892
29MP0002735_abnormal_chemical_nociception2.10465368
30MP0002736_abnormal_nociception_after2.09980467
31MP0001440_abnormal_grooming_behavior2.05161626
32MP0005451_abnormal_body_composition2.00806089
33MP0002332_abnormal_exercise_endurance2.00166566
34MP0005671_abnormal_response_to1.91955574
35MP0002067_abnormal_sensory_capabilities1.88589319
36MP0003091_abnormal_cell_migration1.87964828
37MP0002909_abnormal_adrenal_gland1.85802775
38MP0009785_altered_susceptibility_to1.84313940
39MP0003787_abnormal_imprinting1.83228371
40MP0002148_abnormal_hypersensitivity_rea1.83019580
41MP0002723_abnormal_immune_serum1.81937753
42MP0000685_abnormal_immune_system1.76421598
43MP0001970_abnormal_pain_threshold1.75427809
44MP0004811_abnormal_neuron_physiology1.73293810
45MP0002733_abnormal_thermal_nociception1.73019326
46MP0006082_CNS_inflammation1.72475802
47MP0004858_abnormal_nervous_system1.71310941
48MP0002419_abnormal_innate_immunity1.71086381
49MP0005025_abnormal_response_to1.70982458
50MP0002452_abnormal_antigen_presenting1.70363223
51MP0003329_amyloid_beta_deposits1.69083738
52MP0003879_abnormal_hair_cell1.68963040
53MP0002184_abnormal_innervation1.64872937
54MP0000569_abnormal_digit_pigmentation1.63976483
55MP0004924_abnormal_behavior1.61727263
56MP0005386_behavior/neurological_phenoty1.61727263
57MP0002420_abnormal_adaptive_immunity1.60946495
58MP0001819_abnormal_immune_cell1.58151639
59MP0002557_abnormal_social/conspecific_i1.57859773
60MP0004510_myositis1.55789939
61MP0000778_abnormal_nervous_system1.55627985
62MP0001533_abnormal_skeleton_physiology1.50679346
63MP0003633_abnormal_nervous_system1.48860421
64MP0002998_abnormal_bone_remodeling1.45669040
65MP0002405_respiratory_system_inflammati1.45520510
66MP0003453_abnormal_keratinocyte_physiol1.44162182
67MP0010155_abnormal_intestine_physiology1.43495828
68MP0003172_abnormal_lysosome_physiology1.41431593
69MP0001851_eye_inflammation1.39786985
70MP0000955_abnormal_spinal_cord1.38889300
71MP0000751_myopathy1.37935483
72MP0008961_abnormal_basal_metabolism1.37681424
73MP0005646_abnormal_pituitary_gland1.37473097
74MP0004145_abnormal_muscle_electrophysio1.35627890
75MP0008004_abnormal_stomach_pH1.33734220
76MP0005310_abnormal_salivary_gland1.31796149
77MP0002066_abnormal_motor_capabilities/c1.30919277
78* MP0002398_abnormal_bone_marrow1.24195446
79MP0002882_abnormal_neuron_morphology1.22985993
80MP0003045_fibrosis1.22872356
81MP0004885_abnormal_endolymph1.22690576
82MP0001502_abnormal_circadian_rhythm1.22577342
83MP0010352_gastrointestinal_tract_polyps1.22461235
84* MP0000716_abnormal_immune_system1.22286570
85MP0003631_nervous_system_phenotype1.16048822
86MP0001984_abnormal_olfaction1.14865279
87MP0009333_abnormal_splenocyte_physiolog1.14586984
88MP0001845_abnormal_inflammatory_respons1.13509886
89MP0001348_abnormal_lacrimal_gland1.13030462
90MP0004381_abnormal_hair_follicle1.11725772
91MP0003828_pulmonary_edema1.10943509
92MP0009764_decreased_sensitivity_to1.08476806
93MP0001853_heart_inflammation1.07624301
94MP0008874_decreased_physiological_sensi1.06910106
95MP0003075_altered_response_to1.06375934
96MP0003705_abnormal_hypodermis_morpholog1.05846627
97MP0001873_stomach_inflammation1.01420927
98MP0004484_altered_response_of1.01150984
99MP0003191_abnormal_cellular_cholesterol1.00633420
100MP0005645_abnormal_hypothalamus_physiol0.99632602
101MP0003866_abnormal_defecation0.99380431
102MP0001177_atelectasis0.97025207
103MP0002933_joint_inflammation0.96945200
104* MP0000703_abnormal_thymus_morphology0.95863518
105MP0002152_abnormal_brain_morphology0.95542996
106MP0005164_abnormal_response_to0.95082905
107MP0003448_altered_tumor_morphology0.94678690
108MP0005023_abnormal_wound_healing0.93529563
109MP0005464_abnormal_platelet_physiology0.92424751
110MP0002166_altered_tumor_susceptibility0.91808995
111MP0003656_abnormal_erythrocyte_physiolo0.90193600
112MP0000465_gastrointestinal_hemorrhage0.89947613
113MP0008260_abnormal_autophagy0.89304899
114MP0005076_abnormal_cell_differentiation0.88877223
115MP0001188_hyperpigmentation0.88454606
116MP0004085_abnormal_heartbeat0.88069927
117MP0002009_preneoplasia0.87368893
118MP0000013_abnormal_adipose_tissue0.87266017
119MP0002069_abnormal_eating/drinking_beha0.86483291
120MP0000858_altered_metastatic_potential0.86356510
121MP0003303_peritoneal_inflammation0.86205053
122MP0009278_abnormal_bone_marrow0.85315461
123MP0003183_abnormal_peptide_metabolism0.85283227
124MP0002722_abnormal_immune_system0.85134347
125MP0008872_abnormal_physiological_respon0.84852597
126MP0000604_amyloidosis0.84545579
127MP0002006_tumorigenesis0.83758416
128MP0002837_dystrophic_cardiac_calcinosis0.82835431
129MP0004215_abnormal_myocardial_fiber0.81918041
130MP0005409_darkened_coat_color0.81301743
131MP0003566_abnormal_cell_adhesion0.81166505
132MP0005535_abnormal_body_temperature0.80354279
133MP0004742_abnormal_vestibular_system0.80330867
134MP0001299_abnormal_eye_distance/0.80015608
135* MP0002429_abnormal_blood_cell0.79721389
136MP0000689_abnormal_spleen_morphology0.79057909
137MP0004808_abnormal_hematopoietic_stem0.78972614
138MP0000733_abnormal_muscle_development0.78880100
139MP0005666_abnormal_adipose_tissue0.78481614
140MP0008469_abnormal_protein_level0.75998440
141MP0004130_abnormal_muscle_cell0.75809116
142MP0006276_abnormal_autonomic_nervous0.75754659
143MP0003279_aneurysm0.74907521
144MP0009840_abnormal_foam_cell0.74603821
145MP0005375_adipose_tissue_phenotype0.74149919
146MP0004142_abnormal_muscle_tone0.74111096
147MP0010234_abnormal_vibrissa_follicle0.73569862
148MP0003690_abnormal_glial_cell0.73248510
149MP0001905_abnormal_dopamine_level0.69756387
150MP0002234_abnormal_pharynx_morphology0.68421723
151MP0000920_abnormal_myelination0.67099980
152MP0002229_neurodegeneration0.67030330
153MP0003632_abnormal_nervous_system0.66517558
154MP0004233_abnormal_muscle_weight0.66350268
155MP0005623_abnormal_meninges_morphology0.65972765
156MP0005167_abnormal_blood-brain_barrier0.64878343
157MP0010386_abnormal_urinary_bladder0.61445173
158MP0001963_abnormal_hearing_physiology0.60979529
159MP0003634_abnormal_glial_cell0.60587201
160MP0002090_abnormal_vision0.59969420
161MP0003646_muscle_fatigue0.59387248
162MP0005620_abnormal_muscle_contractility0.58583859
163MP0003137_abnormal_impulse_conducting0.55301317
164MP0005187_abnormal_penis_morphology0.54544436
165MP0003283_abnormal_digestive_organ0.53354548
166MP0000747_muscle_weakness0.53193444
167MP0001943_abnormal_respiration0.53149592
168MP0005499_abnormal_olfactory_system0.52627527
169MP0005394_taste/olfaction_phenotype0.52627527
170MP0010769_abnormal_survival0.52236185
171MP0005166_decreased_susceptibility_to0.51140988
172MP0001664_abnormal_digestion0.50327893
173MP0001529_abnormal_vocalization0.50315791
174MP0005551_abnormal_eye_electrophysiolog0.49508467

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.68202891
2Myokymia (HP:0002411)6.25577700
3Focal seizures (HP:0007359)5.72636311
4Epileptic encephalopathy (HP:0200134)4.81769913
5Visual hallucinations (HP:0002367)4.67718380
6Febrile seizures (HP:0002373)4.44639690
7Atonic seizures (HP:0010819)4.33457269
8Progressive cerebellar ataxia (HP:0002073)4.31228359
9Action tremor (HP:0002345)4.15636970
10Absence seizures (HP:0002121)3.97846733
11Broad-based gait (HP:0002136)3.84730751
12Gaze-evoked nystagmus (HP:0000640)3.63689105
13Dialeptic seizures (HP:0011146)3.59551841
14Generalized tonic-clonic seizures (HP:0002069)3.57250271
15Poor eye contact (HP:0000817)3.40380541
16Eczematoid dermatitis (HP:0000976)3.35010138
17Papilledema (HP:0001085)3.31722839
18Impaired vibration sensation in the lower limbs (HP:0002166)3.29905280
19Hyperventilation (HP:0002883)3.27232278
20Genetic anticipation (HP:0003743)3.22735169
21Dysmetric saccades (HP:0000641)3.22221585
22Retrobulbar optic neuritis (HP:0100654)3.20398443
23Optic neuritis (HP:0100653)3.20398443
24Dysdiadochokinesis (HP:0002075)3.15709203
25Orchitis (HP:0100796)3.14144311
26T lymphocytopenia (HP:0005403)3.14062825
27Abnormal social behavior (HP:0012433)3.11714155
28Impaired social interactions (HP:0000735)3.11714155
29Dysmetria (HP:0001310)3.11389026
30Impaired smooth pursuit (HP:0007772)3.11047412
31Urinary bladder sphincter dysfunction (HP:0002839)3.10283342
32Truncal ataxia (HP:0002078)3.05523395
33Myositis (HP:0100614)2.95260293
34Supranuclear gaze palsy (HP:0000605)2.94502416
35Abnormality of T cell number (HP:0011839)2.91113812
36Depression (HP:0000716)2.87480430
37Excessive salivation (HP:0003781)2.77316427
38Drooling (HP:0002307)2.77316427
39Amblyopia (HP:0000646)2.76894062
40Postural instability (HP:0002172)2.75756479
41Scanning speech (HP:0002168)2.74741904
42Stomatitis (HP:0010280)2.72905238
43Stereotypic behavior (HP:0000733)2.71827193
44Ankle clonus (HP:0011448)2.70115902
45Diplopia (HP:0000651)2.69424691
46Abnormality of binocular vision (HP:0011514)2.69424691
47Urinary urgency (HP:0000012)2.67729026
48Lower limb amyotrophy (HP:0007210)2.63740428
49Slow saccadic eye movements (HP:0000514)2.62728449
50Hemiplegia (HP:0002301)2.62194433
51Abnormality of ocular smooth pursuit (HP:0000617)2.60860818
52Recurrent bacterial skin infections (HP:0005406)2.55092253
53Anxiety (HP:0000739)2.54242430
54Abnormal eating behavior (HP:0100738)2.46748774
55Abnormality of the lower motor neuron (HP:0002366)2.44574642
56Keratoconjunctivitis sicca (HP:0001097)2.43893782
57Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.42009026
58Bundle branch block (HP:0011710)2.39877880
59Mediastinal lymphadenopathy (HP:0100721)2.39724065
60Vasculitis (HP:0002633)2.38357222
61Epileptiform EEG discharges (HP:0011182)2.37922343
62Intention tremor (HP:0002080)2.36115493
63Mutism (HP:0002300)2.34639685
64Autoimmune hemolytic anemia (HP:0001890)2.33753364
65Impaired vibratory sensation (HP:0002495)2.31839918
66Hemiparesis (HP:0001269)2.28132148
67Fetal akinesia sequence (HP:0001989)2.26594470
68Subacute progressive viral hepatitis (HP:0006572)2.25397919
69Torticollis (HP:0000473)2.23287824
70Absent speech (HP:0001344)2.20662871
71Pointed chin (HP:0000307)2.20423562
72Increased IgE level (HP:0003212)2.20417416
73Megalencephaly (HP:0001355)2.20085227
74Hyporeflexia of lower limbs (HP:0002600)2.18915345
75Difficulty running (HP:0009046)2.18887408
76Gastrointestinal infarctions (HP:0005244)2.18740174
77Obstructive sleep apnea (HP:0002870)2.17919869
78Keratoconjunctivitis (HP:0001096)2.17333347
79Annular pancreas (HP:0001734)2.15166194
80EEG with generalized epileptiform discharges (HP:0011198)2.14259826
81Abnormality of macrophages (HP:0004311)2.12502645
82Progressive inability to walk (HP:0002505)2.10866096
83Elevated erythrocyte sedimentation rate (HP:0003565)2.10754866
84Pulmonary infiltrates (HP:0002113)2.10557628
85Gingivitis (HP:0000230)2.09219157
86Termporal pattern (HP:0011008)2.08804401
87Insidious onset (HP:0003587)2.08804401
88Abnormality of the left ventricular outflow tract (HP:0011103)2.08749230
89Subaortic stenosis (HP:0001682)2.08749230
90Spastic gait (HP:0002064)2.08631030
91Bradykinesia (HP:0002067)2.08607070
92Ventricular fibrillation (HP:0001663)2.07812200
93Cerebral inclusion bodies (HP:0100314)2.05627783
94Interstitial pulmonary disease (HP:0006530)2.03408552
95Recurrent abscess formation (HP:0002722)2.02870746
96Focal dystonia (HP:0004373)2.02626635
97Lower limb asymmetry (HP:0100559)1.99936071
98Status epilepticus (HP:0002133)1.99668081
99Recurrent fungal infections (HP:0002841)1.99310989
100Abnormality of the fingertips (HP:0001211)1.99040146
101Hypsarrhythmia (HP:0002521)1.98573462
102Neuronal loss in central nervous system (HP:0002529)1.98397624
103Spontaneous hematomas (HP:0007420)1.98310007
104Inappropriate behavior (HP:0000719)1.98279602
105Overgrowth (HP:0001548)1.97991135
106Type 1 muscle fiber predominance (HP:0003803)1.96498207
107Blue irides (HP:0000635)1.96397924
108Ankyloglossia (HP:0010296)1.95453204
109Aqueductal stenosis (HP:0002410)1.94479720
110Recurrent viral infections (HP:0004429)1.94465112
111Muscle fiber inclusion bodies (HP:0100299)1.91274211
112Lower limb muscle weakness (HP:0007340)1.91071530
113Abnormality of salivation (HP:0100755)1.90125064
114Exercise-induced myalgia (HP:0003738)1.89547602
115Segmental peripheral demyelination/remyelination (HP:0003481)1.89387233
116Colitis (HP:0002583)1.88072590
117Inability to walk (HP:0002540)1.87917079
118Gastrointestinal stroma tumor (HP:0100723)1.87799646
119Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.86410813
120Abnormal EKG (HP:0003115)1.85985270
121Protruding tongue (HP:0010808)1.84361903
122Recurrent bronchitis (HP:0002837)1.83928101
123Macroorchidism (HP:0000053)1.83865556
124Nemaline bodies (HP:0003798)1.83787352
125Pustule (HP:0200039)1.83762603
126Chest pain (HP:0100749)1.83128851
127Incomplete penetrance (HP:0003829)1.83007705
128Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80685957
129Resting tremor (HP:0002322)1.80201089
130Onion bulb formation (HP:0003383)1.79989743
131Abnormal delayed hypersensitivity skin test (HP:0002963)1.79712303
132Gait ataxia (HP:0002066)1.79039673
133Disinhibition (HP:0000734)1.78735662
134Abnormality of saccadic eye movements (HP:0000570)1.78518491
135Neurofibrillary tangles (HP:0002185)1.78312339
136Spondylolisthesis (HP:0003302)1.77715770
137Aortic aneurysm (HP:0004942)1.77324709
138Autoimmune thrombocytopenia (HP:0001973)1.76922329
139Deeply set eye (HP:0000490)1.76357290
140Muscle fiber splitting (HP:0003555)1.75444638
141Arterial tortuosity (HP:0005116)1.75105337
142Widely spaced teeth (HP:0000687)1.74773587
143Asymmetric septal hypertrophy (HP:0001670)1.74096246
144Apathy (HP:0000741)1.73587646
145Dysostosis multiplex (HP:0000943)1.73222414
146Rapidly progressive (HP:0003678)1.72909877
147Spinal canal stenosis (HP:0003416)1.72851348
148Hemoptysis (HP:0002105)1.70953506
149Arterial thrombosis (HP:0004420)1.70672816
150Meningitis (HP:0001287)1.70415604
151Cellulitis (HP:0100658)1.69733233
152Distal lower limb amyotrophy (HP:0008944)1.69189775
153Gangrene (HP:0100758)1.68559579
154Emphysema (HP:0002097)1.68095910
155Craniofacial dystonia (HP:0012179)1.68008058
156Peritonitis (HP:0002586)1.68002527
157Absent frontal sinuses (HP:0002688)1.67983164
158Abnormality of the corticospinal tract (HP:0002492)1.67506298
159Recurrent skin infections (HP:0001581)1.66978962
160Prolonged QT interval (HP:0001657)1.66681609
161Decreased motor nerve conduction velocity (HP:0003431)1.63802280
162Abnormality of the periventricular white matter (HP:0002518)1.63061706
163Sudden death (HP:0001699)1.62978412
164Increased variability in muscle fiber diameter (HP:0003557)1.62813111
165Open mouth (HP:0000194)1.62120612
166Increased connective tissue (HP:0009025)1.61880061
167Generalized myoclonic seizures (HP:0002123)1.61756104
168Frequent falls (HP:0002359)1.61468091
169Vascular tortuosity (HP:0004948)1.61413326
170Leukocytosis (HP:0001974)1.61202368
171Dislocated radial head (HP:0003083)1.61119989
172Abnormality of skeletal muscle fiber size (HP:0012084)1.59454672
173Inflammation of the large intestine (HP:0002037)1.58710883
174Generalized hypopigmentation of hair (HP:0011358)1.58412514
175Vertigo (HP:0002321)1.57571824
176Abnormality of T cells (HP:0002843)1.56593817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.75877909
2NTRK34.48441648
3MAP3K93.56649720
4DAPK22.84807027
5MAP3K42.71472006
6RIPK42.56536003
7MARK12.46088058
8MAP4K12.39253050
9MINK12.33750701
10MAP3K142.18713605
11PAK62.12433602
12MAP2K72.08261156
13CAMKK11.99297558
14IRAK31.97296208
15PRKD31.94950467
16KSR21.94945092
17NTRK21.94685908
18DAPK11.75652675
19SIK21.73192288
20TXK1.71944436
21KSR11.66067150
22MAP2K41.65737746
23IKBKE1.65530663
24PRPF4B1.64884004
25CDK121.63870718
26TYK21.58335907
27NTRK11.55155024
28CDK51.50429386
29CASK1.49631144
30TNIK1.47499793
31MAP3K131.47072961
32TAOK11.44941635
33CSK1.35627909
34ZAP701.34857813
35STK381.32358213
36BLK1.32300950
37PLK21.32140866
38FES1.31095456
39CAMKK21.30192288
40FGFR41.27416509
41MAP3K21.26975145
42MAP3K31.24799142
43TYRO31.22387142
44MAP3K121.22037672
45TBK11.18886170
46MAP2K31.14107440
47PRKCH1.13261188
48MAPK131.12950111
49CDK191.10592532
50TAOK21.10004692
51PRKCG1.09770968
52RIPK11.05765733
53CAMK11.04770378
54SGK21.03904376
55OBSCN1.03682694
56JAK31.03608319
57SGK31.02499272
58TTN1.02380890
59AKT31.01682915
60NLK1.01286590
61DMPK1.01090200
62PTK2B1.00821998
63MAP3K71.00113340
64STK111.00066947
65BMPR20.99600836
66ERN10.99160847
67IRAK40.98778736
68MOS0.98220326
69GRK50.97943383
70RET0.97801150
71JAK20.97234301
72MARK20.95163438
73IKBKB0.94505522
74PDGFRA0.93773180
75CAMK2A0.93330997
76PDK10.92851233
77SYK0.91559497
78CAMK1G0.91391345
79HIPK20.90701892
80SGK4940.90631460
81SGK2230.90631460
82SGK10.89250276
83EPHB10.88690816
84ICK0.86934030
85MAP3K100.86292615
86RAF10.86194254
87PDGFRB0.84546279
88PHKG10.83711503
89PHKG20.83711503
90BTK0.83611019
91PNCK0.83593922
92HCK0.83152879
93CHUK0.81860348
94ITK0.81054215
95EPHA30.79751505
96DDR20.78886213
97CAMK2B0.78836254
98IRAK20.78180870
99GRK70.77567451
100TRIB30.77015034
101TGFBR20.75360727
102ALK0.74649714
103PDPK10.73234599
104MAP3K110.72086440
105FGR0.70051935
106LCK0.69278123
107CDK180.65965703
108CDK150.64046169
109TRPM70.63738218
110MAP3K10.63627314
111DYRK1A0.63072431
112PAK30.62868086
113UHMK10.59957157
114MAPK120.59473023
115CAMK40.59313540
116FYN0.58768066
117CDK140.57518934
118IRAK10.56850441
119TAOK30.56613117
120MELK0.54002688
121LMTK20.53896665
122ARAF0.53598043
123CDK11A0.53266803
124MAPK110.53192833
125CDC42BPA0.53064855
126RPS6KA30.52835894
127SIK10.52814512
128NEK60.52587992
129FGFR20.52344563
130BRD40.51633584
131CAMK1D0.49923157
132STK240.49617889
133JAK10.48819882
134TNK20.48151929
135MAPK40.48068993
136MARK30.47330504
137MAPK100.46022390
138LATS20.45327000
139MAP3K60.44674369
140SIK30.44484659
141MAPK70.43897386
142FGFR30.43681018
143WNK10.43626720
144PRKCE0.42832696
145CSNK1G20.41722045
146FER0.41340672
147CCNB10.39943941
148PRKCQ0.39853803
149PRKCZ0.39197397
150PINK10.38658939
151OXSR10.34124873
152NME10.33822813
153PRKCB0.33368902
154DAPK30.32692282
155MAP2K10.32596496
156CAMK2D0.32460809

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.18011573
2Long-term potentiation_Homo sapiens_hsa047202.70023245
3Circadian entrainment_Homo sapiens_hsa047132.57118800
4Synaptic vesicle cycle_Homo sapiens_hsa047212.45494612
5Olfactory transduction_Homo sapiens_hsa047402.43274217
6Glutamatergic synapse_Homo sapiens_hsa047242.40173103
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35126373
8Amphetamine addiction_Homo sapiens_hsa050312.28669326
9Morphine addiction_Homo sapiens_hsa050322.23742919
10Salivary secretion_Homo sapiens_hsa049702.18435159
11GABAergic synapse_Homo sapiens_hsa047272.17753468
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94517852
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.91534501
14Dopaminergic synapse_Homo sapiens_hsa047281.89799610
15Insulin secretion_Homo sapiens_hsa049111.88920024
16Gastric acid secretion_Homo sapiens_hsa049711.84502938
17Cholinergic synapse_Homo sapiens_hsa047251.80367009
18Oxytocin signaling pathway_Homo sapiens_hsa049211.74199154
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73237631
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.71261006
21Renin secretion_Homo sapiens_hsa049241.71139200
22TNF signaling pathway_Homo sapiens_hsa046681.64568767
23Long-term depression_Homo sapiens_hsa047301.61618789
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61067178
25Calcium signaling pathway_Homo sapiens_hsa040201.60342898
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55598398
27Leishmaniasis_Homo sapiens_hsa051401.46860401
28Taste transduction_Homo sapiens_hsa047421.46759127
29GnRH signaling pathway_Homo sapiens_hsa049121.43646318
30Cocaine addiction_Homo sapiens_hsa050301.39861613
31Type II diabetes mellitus_Homo sapiens_hsa049301.37999082
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36311662
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35621677
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35292209
35Acute myeloid leukemia_Homo sapiens_hsa052211.34995634
36Serotonergic synapse_Homo sapiens_hsa047261.33350673
37cAMP signaling pathway_Homo sapiens_hsa040241.33035817
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29991829
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28976153
40Glioma_Homo sapiens_hsa052141.25792897
41Tuberculosis_Homo sapiens_hsa051521.23611481
42Measles_Homo sapiens_hsa051621.22546719
43Gap junction_Homo sapiens_hsa045401.21361484
44Malaria_Homo sapiens_hsa051441.20441764
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20097852
46Toxoplasmosis_Homo sapiens_hsa051451.18400560
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18289952
48Graft-versus-host disease_Homo sapiens_hsa053321.15935206
49Estrogen signaling pathway_Homo sapiens_hsa049151.15589727
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.14140139
51Allograft rejection_Homo sapiens_hsa053301.13962631
52Influenza A_Homo sapiens_hsa051641.12793919
53Chronic myeloid leukemia_Homo sapiens_hsa052201.10079721
54ErbB signaling pathway_Homo sapiens_hsa040121.08285560
55Hepatitis B_Homo sapiens_hsa051611.06141465
56Hepatitis C_Homo sapiens_hsa051601.04847217
57Axon guidance_Homo sapiens_hsa043601.03838771
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03364355
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00197386
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98958135
61Pancreatic cancer_Homo sapiens_hsa052120.98378963
62Dilated cardiomyopathy_Homo sapiens_hsa054140.98309810
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.98069250
64Melanogenesis_Homo sapiens_hsa049160.97180118
65Dorso-ventral axis formation_Homo sapiens_hsa043200.96778784
66Autoimmune thyroid disease_Homo sapiens_hsa053200.94851032
67Pertussis_Homo sapiens_hsa051330.94389046
68FoxO signaling pathway_Homo sapiens_hsa040680.93692455
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.92947423
70Pancreatic secretion_Homo sapiens_hsa049720.92107661
71Amoebiasis_Homo sapiens_hsa051460.90718383
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90080146
73Primary immunodeficiency_Homo sapiens_hsa053400.87504077
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.85314008
75MAPK signaling pathway_Homo sapiens_hsa040100.85102404
76Choline metabolism in cancer_Homo sapiens_hsa052310.84794654
77VEGF signaling pathway_Homo sapiens_hsa043700.84714200
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84470363
79Legionellosis_Homo sapiens_hsa051340.84107221
80Staphylococcus aureus infection_Homo sapiens_hsa051500.83390026
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.81603181
82Nitrogen metabolism_Homo sapiens_hsa009100.80891060
83Rheumatoid arthritis_Homo sapiens_hsa053230.80734380
84Prion diseases_Homo sapiens_hsa050200.80079487
85Salmonella infection_Homo sapiens_hsa051320.79129926
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.77764982
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.77473888
88Hematopoietic cell lineage_Homo sapiens_hsa046400.77398928
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75901611
90Insulin resistance_Homo sapiens_hsa049310.75512771
91Thyroid hormone synthesis_Homo sapiens_hsa049180.75508108
92Collecting duct acid secretion_Homo sapiens_hsa049660.75292640
93mTOR signaling pathway_Homo sapiens_hsa041500.75283625
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74917347
95Circadian rhythm_Homo sapiens_hsa047100.74514027
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74405573
97Viral myocarditis_Homo sapiens_hsa054160.71939060
98Rap1 signaling pathway_Homo sapiens_hsa040150.71118663
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70669133
100Prostate cancer_Homo sapiens_hsa052150.69992451
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68952897
102Apoptosis_Homo sapiens_hsa042100.67722121
103HIF-1 signaling pathway_Homo sapiens_hsa040660.67444617
104Herpes simplex infection_Homo sapiens_hsa051680.67312805
105Glucagon signaling pathway_Homo sapiens_hsa049220.66799704
106T cell receptor signaling pathway_Homo sapiens_hsa046600.65548740
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64848072
108Ras signaling pathway_Homo sapiens_hsa040140.63829967
109Inositol phosphate metabolism_Homo sapiens_hsa005620.63618682
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63382661
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62362526
112Non-small cell lung cancer_Homo sapiens_hsa052230.62011114
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61337624
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.60608824
115Oocyte meiosis_Homo sapiens_hsa041140.59829809
116Chemokine signaling pathway_Homo sapiens_hsa040620.59091450
117African trypanosomiasis_Homo sapiens_hsa051430.58922973
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58172987
119Cardiac muscle contraction_Homo sapiens_hsa042600.55791811
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55607843
121Endometrial cancer_Homo sapiens_hsa052130.55575018
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55537023
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55098443
124Platelet activation_Homo sapiens_hsa046110.53782938
125Endocytosis_Homo sapiens_hsa041440.52143578
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51345238
127Renal cell carcinoma_Homo sapiens_hsa052110.51094428
128B cell receptor signaling pathway_Homo sapiens_hsa046620.49343297
129Insulin signaling pathway_Homo sapiens_hsa049100.49234376
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45479550
131Wnt signaling pathway_Homo sapiens_hsa043100.45122303
132Type I diabetes mellitus_Homo sapiens_hsa049400.44533317
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42974089
134Vibrio cholerae infection_Homo sapiens_hsa051100.41245789
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40427046
136Prolactin signaling pathway_Homo sapiens_hsa049170.39813865
137Colorectal cancer_Homo sapiens_hsa052100.39431328
138Phototransduction_Homo sapiens_hsa047440.38709215
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38681123
140Bile secretion_Homo sapiens_hsa049760.38678140
141Osteoclast differentiation_Homo sapiens_hsa043800.37489136

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