HIST3H2BB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)9.68054953
2alanine transport (GO:0032328)6.10108115
3behavioral response to nicotine (GO:0035095)5.71588863
4regulation of gene silencing (GO:0060968)5.37556801
5viral mRNA export from host cell nucleus (GO:0046784)4.46160101
6L-serine transport (GO:0015825)4.36468656
7DNA replication-dependent nucleosome organization (GO:0034723)4.29130143
8DNA replication-dependent nucleosome assembly (GO:0006335)4.29130143
9peristalsis (GO:0030432)3.93227800
10tryptophan metabolic process (GO:0006568)3.79648675
11L-fucose catabolic process (GO:0042355)3.67867767
12fucose catabolic process (GO:0019317)3.67867767
13L-fucose metabolic process (GO:0042354)3.67867767
14protein polyglutamylation (GO:0018095)3.65066860
15serine transport (GO:0032329)3.63863365
16osteoblast development (GO:0002076)3.62263530
17mucosal immune response (GO:0002385)3.60821971
18ubiquinone metabolic process (GO:0006743)3.60221020
19negative regulation of transcription regulatory region DNA binding (GO:2000678)3.42538163
20indolalkylamine metabolic process (GO:0006586)3.36606746
21gene silencing by RNA (GO:0031047)3.35691348
22innate immune response in mucosa (GO:0002227)3.34267875
23ubiquinone biosynthetic process (GO:0006744)3.30876470
24kynurenine metabolic process (GO:0070189)3.28743056
25protein K6-linked ubiquitination (GO:0085020)3.25052867
26tryptophan catabolic process (GO:0006569)3.24997575
27indole-containing compound catabolic process (GO:0042436)3.24997575
28indolalkylamine catabolic process (GO:0046218)3.24997575
29sulfation (GO:0051923)3.21162519
30organ or tissue specific immune response (GO:0002251)3.19548186
31male meiosis (GO:0007140)3.09788307
32negative regulation of reactive oxygen species metabolic process (GO:2000378)3.08730020
33peptidyl-histidine modification (GO:0018202)3.07718811
34nephron tubule morphogenesis (GO:0072078)3.06931988
35nephron epithelium morphogenesis (GO:0072088)3.06931988
36axoneme assembly (GO:0035082)3.05256597
37protein-cofactor linkage (GO:0018065)2.99791789
38negative regulation of histone acetylation (GO:0035067)2.97906624
39mitochondrial respiratory chain complex assembly (GO:0033108)2.95681929
40positive regulation of histone acetylation (GO:0035066)2.95197187
41negative regulation of macrophage differentiation (GO:0045650)2.94137455
42mechanosensory behavior (GO:0007638)2.92189576
43urinary tract smooth muscle contraction (GO:0014848)2.89848885
44chromatin assembly (GO:0031497)2.89004042
45replication fork processing (GO:0031297)2.85349233
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83904247
47phasic smooth muscle contraction (GO:0014821)2.83458643
48histone H3-K9 methylation (GO:0051567)2.78869074
49rRNA catabolic process (GO:0016075)2.76914355
50photoreceptor cell maintenance (GO:0045494)2.74766615
51protein complex biogenesis (GO:0070271)2.74712464
52transmission of nerve impulse (GO:0019226)2.74454627
53dermatan sulfate biosynthetic process (GO:0030208)2.73997113
54positive regulation of protein acetylation (GO:1901985)2.71140312
55positive regulation of peptidyl-lysine acetylation (GO:2000758)2.71140312
56negative regulation of mast cell activation (GO:0033004)2.70820313
57negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.67675206
58water-soluble vitamin biosynthetic process (GO:0042364)2.67044508
59regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.66061173
60regulation of mitotic spindle checkpoint (GO:1903504)2.66061173
61recombinational repair (GO:0000725)2.64277747
62postsynaptic membrane organization (GO:0001941)2.64169468
63response to pheromone (GO:0019236)2.62514607
64double-strand break repair via homologous recombination (GO:0000724)2.61637557
65mitochondrial calcium ion transport (GO:0006851)2.60622052
66neuronal action potential (GO:0019228)2.60259262
67quinone biosynthetic process (GO:1901663)2.59340233
68establishment of protein localization to mitochondrial membrane (GO:0090151)2.58907865
69cAMP catabolic process (GO:0006198)2.58860445
70reflex (GO:0060004)2.57970167
71negative regulation of peptidyl-lysine acetylation (GO:2000757)2.56168609
72antibacterial humoral response (GO:0019731)2.51484439
73sex differentiation (GO:0007548)2.48313126
74histone H3-K9 modification (GO:0061647)2.47412186
75maturation of SSU-rRNA (GO:0030490)2.46907613
76somatic hypermutation of immunoglobulin genes (GO:0016446)2.46896945
77somatic diversification of immune receptors via somatic mutation (GO:0002566)2.46896945
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.46035284
79negative regulation of telomere maintenance (GO:0032205)2.45869581
80cilium movement (GO:0003341)2.45790150
81negative regulation of synaptic transmission, GABAergic (GO:0032229)2.45146945
82piRNA metabolic process (GO:0034587)2.42983426
83mitochondrial respiratory chain complex I assembly (GO:0032981)2.41845023
84NADH dehydrogenase complex assembly (GO:0010257)2.41845023
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.41845023
86maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.41115762
87cellular ketone body metabolic process (GO:0046950)2.39403119
88mitochondrion distribution (GO:0048311)2.37344801
89auditory behavior (GO:0031223)2.37188778
90fucosylation (GO:0036065)2.34867727
91cardiac right ventricle morphogenesis (GO:0003215)2.34042475
92indole-containing compound metabolic process (GO:0042430)2.33725070
93postreplication repair (GO:0006301)2.33664962
94nucleosome assembly (GO:0006334)2.32657295
95maturation of 5.8S rRNA (GO:0000460)2.31782706
96DNA deamination (GO:0045006)2.31568205
97regulation of hippo signaling (GO:0035330)11.5435635
98regulation of posttranscriptional gene silencing (GO:0060147)10.5692930
99regulation of gene silencing by miRNA (GO:0060964)10.5692930
100regulation of gene silencing by RNA (GO:0060966)10.5692930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.53589397
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.03035149
3VDR_22108803_ChIP-Seq_LS180_Human2.83108803
4AR_21572438_ChIP-Seq_LNCaP_Human2.63858149
5* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61399797
6IGF1R_20145208_ChIP-Seq_DFB_Human2.40937843
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14776558
8IRF1_19129219_ChIP-ChIP_H3396_Human2.08797848
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.05299245
10GBX2_23144817_ChIP-Seq_PC3_Human2.00746614
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse12.7775537
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91225203
13POU5F1_16153702_ChIP-ChIP_HESCs_Human1.89917452
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83423716
15EZH2_22144423_ChIP-Seq_EOC_Human1.82144254
16NOTCH1_21737748_ChIP-Seq_TLL_Human1.82126867
17E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79567106
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79067364
19EWS_26573619_Chip-Seq_HEK293_Human1.77271560
20* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75236815
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.73327263
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72861225
23MYC_18940864_ChIP-ChIP_HL60_Human1.69748694
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68054089
25ELK1_19687146_ChIP-ChIP_HELA_Human1.66467473
26TDRD3_21172665_ChIP-Seq_MCF-7_Human1.65412705
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63370537
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.62586329
29ER_23166858_ChIP-Seq_MCF-7_Human1.61183973
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59603990
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50290249
32* SOX2_16153702_ChIP-ChIP_HESCs_Human1.49468287
33FUS_26573619_Chip-Seq_HEK293_Human1.47485363
34* VDR_23849224_ChIP-Seq_CD4+_Human1.43596535
35E2F7_22180533_ChIP-Seq_HELA_Human1.37419304
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34646428
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.30792768
38P300_19829295_ChIP-Seq_ESCs_Human1.29418739
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29363878
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27819416
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.27437578
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27437578
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22799480
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22469265
45GATA3_21878914_ChIP-Seq_MCF-7_Human1.20513427
46RNF2_27304074_Chip-Seq_NSC_Mouse1.20477515
47LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19707487
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.16314232
49REST_21632747_ChIP-Seq_MESCs_Mouse1.16083560
50TP53_22573176_ChIP-Seq_HFKS_Human1.15523068
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15475243
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13615711
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10617922
54HOXB7_26014856_ChIP-Seq_BT474_Human1.08924879
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07720211
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.06767909
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05259165
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.02832147
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01735024
60AR_25329375_ChIP-Seq_VCAP_Human1.01004418
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00991690
62HTT_18923047_ChIP-ChIP_STHdh_Human1.00386087
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98252824
64PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97774691
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96330830
66PIAS1_25552417_ChIP-Seq_VCAP_Human0.96101116
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95944579
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95905057
69NCOR_22424771_ChIP-Seq_293T_Human0.95790559
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95080601
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93383986
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.91737622
73STAT3_23295773_ChIP-Seq_U87_Human0.90718856
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90094647
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89035219
76AR_20517297_ChIP-Seq_VCAP_Human0.88362928
77FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87425764
78SRF_21415370_ChIP-Seq_HL-1_Mouse0.86005417
79TCF4_23295773_ChIP-Seq_U87_Human0.85639135
80ERA_21632823_ChIP-Seq_H3396_Human0.85271953
81EZH2_27304074_Chip-Seq_ESCs_Mouse0.85249638
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.81938834
83* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81858865
84JARID2_20064375_ChIP-Seq_MESCs_Mouse0.81135096
85CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80862827
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.80475814
87KDM5A_27292631_Chip-Seq_BREAST_Human0.79881671
88* NANOG_16153702_ChIP-ChIP_HESCs_Human0.79423959
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.77471278
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76918752
91NANOG_19829295_ChIP-Seq_ESCs_Human0.76759552
92SOX2_19829295_ChIP-Seq_ESCs_Human0.76759552
93KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76515337
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.76009841
95WDR5_24793694_ChIP-Seq_LNCAP_Human0.75883938
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.75732804
97CBP_20019798_ChIP-Seq_JUKART_Human0.75732804
98RUNX2_22187159_ChIP-Seq_PCA_Human0.75475788
99* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.75423822
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.75387049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.53028856
2MP0002876_abnormal_thyroid_physiology3.13265865
3MP0002254_reproductive_system_inflammat2.96765452
4MP0002653_abnormal_ependyma_morphology2.90276825
5MP0000427_abnormal_hair_cycle2.69426698
6MP0000383_abnormal_hair_follicle2.62771504
7MP0009379_abnormal_foot_pigmentation2.57064654
8MP0009046_muscle_twitch2.35100732
9MP0004133_heterotaxia2.33405845
10MP0003195_calcinosis2.27279494
11MP0002277_abnormal_respiratory_mucosa2.25597073
12MP0005551_abnormal_eye_electrophysiolog2.22358112
13MP0000372_irregular_coat_pigmentation2.19615394
14MP0001968_abnormal_touch/_nociception2.18501969
15MP0002735_abnormal_chemical_nociception1.93413449
16MP0002160_abnormal_reproductive_system1.93309237
17MP0001485_abnormal_pinna_reflex1.90111885
18MP0005389_reproductive_system_phenotype1.87741157
19MP0006072_abnormal_retinal_apoptosis1.85824405
20MP0001919_abnormal_reproductive_system1.82269656
21MP0002163_abnormal_gland_morphology1.79494677
22MP0009745_abnormal_behavioral_response1.67778244
23MP0005171_absent_coat_pigmentation1.66261018
24MP0000613_abnormal_salivary_gland1.65283790
25MP0000631_abnormal_neuroendocrine_gland1.61299187
26MP0003283_abnormal_digestive_organ1.58406262
27MP0003693_abnormal_embryo_hatching1.58094929
28MP0004742_abnormal_vestibular_system1.56605565
29MP0010678_abnormal_skin_adnexa1.56516298
30MP0001529_abnormal_vocalization1.53306569
31MP0001873_stomach_inflammation1.51607779
32MP0002638_abnormal_pupillary_reflex1.47592185
33MP0005253_abnormal_eye_physiology1.46061328
34MP0001764_abnormal_homeostasis1.45610249
35MP0003937_abnormal_limbs/digits/tail_de1.45089148
36MP0008058_abnormal_DNA_repair1.40797752
37MP0002064_seizures1.39769104
38MP0002138_abnormal_hepatobiliary_system1.37488783
39MP0004142_abnormal_muscle_tone1.36981635
40MP0006292_abnormal_olfactory_placode1.36475273
41MP0008877_abnormal_DNA_methylation1.36300311
42MP0001293_anophthalmia1.35865642
43MP0005220_abnormal_exocrine_pancreas1.35124335
44MP0008875_abnormal_xenobiotic_pharmacok1.34072881
45MP0008872_abnormal_physiological_respon1.33921802
46MP0002272_abnormal_nervous_system1.32780550
47MP0005379_endocrine/exocrine_gland_phen1.31803683
48MP0002095_abnormal_skin_pigmentation1.29421251
49MP0000470_abnormal_stomach_morphology1.26953014
50MP0003786_premature_aging1.23575432
51MP0004043_abnormal_pH_regulation1.23507156
52MP0000538_abnormal_urinary_bladder1.22711792
53MP0002938_white_spotting1.19598677
54MP0002736_abnormal_nociception_after1.18856333
55MP0010094_abnormal_chromosome_stability1.16694713
56MP0005195_abnormal_posterior_eye1.15443999
57MP0008995_early_reproductive_senescence1.11157368
58MP0002282_abnormal_trachea_morphology1.10656160
59MP0004885_abnormal_endolymph1.08662811
60MP0001486_abnormal_startle_reflex1.07938877
61MP0004185_abnormal_adipocyte_glucose1.07888637
62MP0002102_abnormal_ear_morphology1.07801766
63MP0002210_abnormal_sex_determination1.07507875
64MP0005310_abnormal_salivary_gland1.06003074
65MP0000049_abnormal_middle_ear1.05515384
66MP0002098_abnormal_vibrissa_morphology1.05258062
67MP0002557_abnormal_social/conspecific_i1.02390325
68MP0005332_abnormal_amino_acid0.98674579
69MP0001929_abnormal_gametogenesis0.98264742
70MP0005084_abnormal_gallbladder_morpholo0.98176418
71MP0003698_abnormal_male_reproductive0.96513232
72MP0001324_abnormal_eye_pigmentation0.96306382
73MP0001984_abnormal_olfaction0.95053815
74MP0002572_abnormal_emotion/affect_behav0.94636058
75MP0002837_dystrophic_cardiac_calcinosis0.94499358
76MP0003718_maternal_effect0.93882015
77MP0000653_abnormal_sex_gland0.92433668
78MP0001986_abnormal_taste_sensitivity0.92048150
79MP0009250_abnormal_appendicular_skeleto0.91766000
80MP0001145_abnormal_male_reproductive0.89257637
81MP0005083_abnormal_biliary_tract0.88643791
82MP0002751_abnormal_autonomic_nervous0.88406899
83MP0002733_abnormal_thermal_nociception0.88210659
84MP0003137_abnormal_impulse_conducting0.87907818
85MP0000371_diluted_coat_color0.87704764
86MP0001944_abnormal_pancreas_morphology0.87532835
87MP0005645_abnormal_hypothalamus_physiol0.87470403
88MP0002067_abnormal_sensory_capabilities0.86900522
89MP0005646_abnormal_pituitary_gland0.86349190
90MP0001970_abnormal_pain_threshold0.85752522
91MP0002928_abnormal_bile_duct0.83905273
92MP0009697_abnormal_copulation0.83228946
93MP0005391_vision/eye_phenotype0.81944372
94MP0003011_delayed_dark_adaptation0.81009993
95MP0002752_abnormal_somatic_nervous0.80451820
96MP0006276_abnormal_autonomic_nervous0.76216058
97MP0002734_abnormal_mechanical_nocicepti0.74113039
98MP0003635_abnormal_synaptic_transmissio0.74084535
99MP0005503_abnormal_tendon_morphology0.73881926
100MP0003890_abnormal_embryonic-extraembry0.73142759

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.86745868
2True hermaphroditism (HP:0010459)3.68821016
3Pancreatic cysts (HP:0001737)3.53483593
4Pancreatic fibrosis (HP:0100732)3.44586304
5Molar tooth sign on MRI (HP:0002419)3.39406642
6Abnormality of midbrain morphology (HP:0002418)3.39406642
7Abolished electroretinogram (ERG) (HP:0000550)3.20638000
8Congenital stationary night blindness (HP:0007642)3.12134513
9Abnormal number of erythroid precursors (HP:0012131)3.11922932
10Congenital, generalized hypertrichosis (HP:0004540)3.00784962
11Occipital encephalocele (HP:0002085)2.96492904
12Hyperventilation (HP:0002883)2.95060697
13Abnormality of cells of the erythroid lineage (HP:0012130)2.85906980
14Nephronophthisis (HP:0000090)2.83987447
15Abnormality of the pons (HP:0007361)2.80721811
16Reticulocytopenia (HP:0001896)2.72780385
17Abnormality of the renal cortex (HP:0011035)2.68388947
18Sclerocornea (HP:0000647)2.62444607
19Hypoplasia of the pons (HP:0012110)2.61825977
20Renal cortical cysts (HP:0000803)2.55831754
21Neoplasm of head and neck (HP:0012288)2.54603039
22Esophageal neoplasm (HP:0100751)2.54603039
23Retinal dysplasia (HP:0007973)2.53987648
24Large for gestational age (HP:0001520)2.51379741
25Lissencephaly (HP:0001339)2.50775908
26Hypoplasia of the radius (HP:0002984)2.50402115
27Broad-based gait (HP:0002136)2.48495282
28Furrowed tongue (HP:0000221)2.47092064
29Aplasia/Hypoplasia of the tibia (HP:0005772)2.41317502
30Abnormality of the renal medulla (HP:0100957)2.39884263
31Cerebellar dysplasia (HP:0007033)2.38519871
32Hypothermia (HP:0002045)2.36365509
33Hypoplastic pelvis (HP:0008839)2.34670670
34Mesangial abnormality (HP:0001966)2.34434541
35Chronic hepatic failure (HP:0100626)2.33441863
36Oligodactyly (HP:0012165)2.29568645
37Synostosis involving the elbow (HP:0003938)2.27277347
38Humeroradial synostosis (HP:0003041)2.27277347
39Absent thumb (HP:0009777)2.27103528
40Patellar aplasia (HP:0006443)2.26757897
41Aplasia/Hypoplasia of the patella (HP:0006498)2.24769798
42Severe muscular hypotonia (HP:0006829)2.19565053
43Pendular nystagmus (HP:0012043)2.19471339
44Mesomelia (HP:0003027)2.19166628
45Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13592169
46Optic nerve hypoplasia (HP:0000609)2.13076085
47Cystic liver disease (HP:0006706)2.12768373
48Abnormal biliary tract physiology (HP:0012439)2.10791005
49Bile duct proliferation (HP:0001408)2.10791005
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.10645085
51Abnormal ciliary motility (HP:0012262)2.09776064
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09100483
53Abnormality of the carotid arteries (HP:0005344)2.07731719
54Septo-optic dysplasia (HP:0100842)2.07294937
55Birth length less than 3rd percentile (HP:0003561)2.05970302
56Esophageal atresia (HP:0002032)2.04954485
57Congenital sensorineural hearing impairment (HP:0008527)2.03996897
58Abnormal respiratory motile cilium morphology (HP:0005938)2.03604889
59Abnormal respiratory epithelium morphology (HP:0012253)2.03604889
60Anencephaly (HP:0002323)2.01478197
61Male pseudohermaphroditism (HP:0000037)1.98980909
62Abnormality of the ileum (HP:0001549)1.97648903
63Short tibia (HP:0005736)1.95365604
64Inability to walk (HP:0002540)1.94559981
65Redundant skin (HP:0001582)1.94302808
66Abnormality of alanine metabolism (HP:0010916)1.93145407
67Hyperalaninemia (HP:0003348)1.93145407
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93145407
69Abnormality of the renal collecting system (HP:0004742)1.92362853
70Scotoma (HP:0000575)1.90731812
71Duplicated collecting system (HP:0000081)1.90200721
72Meckel diverticulum (HP:0002245)1.86723355
73Partial agenesis of the corpus callosum (HP:0001338)1.85453230
74Dandy-Walker malformation (HP:0001305)1.84913246
75Genetic anticipation (HP:0003743)1.84165779
76Concave nail (HP:0001598)1.83335095
77Morphological abnormality of the inner ear (HP:0011390)1.82864453
78Chorioretinal atrophy (HP:0000533)1.81784532
79Pachygyria (HP:0001302)1.81730322
80Bony spicule pigmentary retinopathy (HP:0007737)1.80257002
81Neoplasm of the adrenal cortex (HP:0100641)1.79312581
82Attenuation of retinal blood vessels (HP:0007843)1.78224295
83Decreased central vision (HP:0007663)1.77762638
84Agitation (HP:0000713)1.77654679
85Anomalous pulmonary venous return (HP:0010772)1.76920505
86Disproportionate short-trunk short stature (HP:0003521)1.76285058
87Hypoplasia of the uterus (HP:0000013)1.74774196
88Oligodactyly (hands) (HP:0001180)1.73652281
893-Methylglutaconic aciduria (HP:0003535)1.73213257
90Gastrointestinal atresia (HP:0002589)1.72309876
91Confusion (HP:0001289)1.71803834
92Forearm undergrowth (HP:0009821)1.71260760
93Aplasia/hypoplasia of the uterus (HP:0008684)1.71178622
94Mitochondrial inheritance (HP:0001427)1.70867126
95Ulnar claw (HP:0001178)1.70412090
96Chromsome breakage (HP:0040012)1.70101565
97Postaxial foot polydactyly (HP:0001830)1.69574633
98Bulbous nose (HP:0000414)1.68956689
99Acute necrotizing encephalopathy (HP:0006965)1.68885379
100Reduced antithrombin III activity (HP:0001976)1.68607224

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK7.08790274
2TLK17.06944561
3WNK43.25882421
4FRK3.13317900
5VRK12.95754281
6PNCK2.78279653
7RPS6KA52.58421144
8CASK2.40727674
9NUAK12.39967818
10ADRBK21.99179778
11GRK11.95942761
12WEE11.94628108
13MAPK151.83660930
14WNK31.78918562
15BMPR1B1.69417286
16TSSK61.62512291
17CAMKK21.60323318
18PKN11.42799385
19MAP4K21.42138396
20BUB11.41949521
21STK391.38593543
22PINK11.38563376
23INSRR1.26037384
24CAMK1D1.21504144
25CHEK21.16646401
26AURKA1.10788473
27DAPK31.03571213
28OXSR10.94231744
29PTK60.92617528
30STK160.91346488
31STK40.90101074
32MAPK130.90030975
33IRAK10.88541256
34TGFBR10.85934798
35PRKCG0.84459848
36PAK30.81858891
37MAPKAPK30.80716816
38CDK80.79376363
39CDC70.76701174
40EPHA30.75209476
41BCKDK0.72824631
42CSNK1G10.70353478
43PIM10.70291761
44MAP2K60.70070005
45MAP2K20.66449733
46ACVR1B0.64961308
47NTRK30.63828840
48PLK30.63233091
49MAP3K40.63213469
50BRSK20.63101089
51CAMK1G0.61458133
52ATR0.59668384
53DYRK20.59615083
54CCNB10.57352984
55IRAK40.56731789
56IKBKB0.55992519
57TXK0.54667595
58ADRBK10.54385228
59PRKCQ0.53141203
60PRKCI0.52401495
61STK110.50378288
62CSNK1G30.48501206
63PLK40.47498878
64PRKAA10.46854827
65RPS6KA60.44735449
66CAMKK10.44673631
67MAPKAPK50.44494017
68MAP2K70.43900622
69PASK0.43899135
70AURKB0.43344946
71PLK10.42650237
72TAF10.42457286
73CSNK1G20.40738143
74TIE10.39879358
75AKT20.38138463
76NLK0.35942313
77PDGFRB0.35919926
78JAK20.35509572
79CSNK1A1L0.34231396
80WNK10.34025814
81STK380.33134829
82PHKG20.32814068
83PHKG10.32814068
84ATM0.32037230
85CHUK0.30624245
86MKNK20.29729761
87NME10.27472221
88PRKACA0.26662354
89PBK0.25336559
90FGFR20.25233846
91MUSK0.23877308
92PRKCZ0.23541546
93MAP2K40.20885671
94PRKCE0.20538688
95MAPK80.19590272
96PRKCD0.19536156
97CDK10.19342191
98RPS6KB10.19326952
99RPS6KA10.18310006
100CSNK2A10.17379038

Predicted pathways (KEGG)

RankGene SetZ-score
1* Systemic lupus erythematosus_Homo sapiens_hsa053225.50182211
2* Alcoholism_Homo sapiens_hsa050344.22229522
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.83759072
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.80124048
5Ribosome_Homo sapiens_hsa030102.64115908
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.61646336
7Selenocompound metabolism_Homo sapiens_hsa004502.56387940
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.30072117
9Homologous recombination_Homo sapiens_hsa034402.15906188
10Oxidative phosphorylation_Homo sapiens_hsa001901.92766053
11RNA polymerase_Homo sapiens_hsa030201.91075928
12Fanconi anemia pathway_Homo sapiens_hsa034601.84998683
13Phototransduction_Homo sapiens_hsa047441.77276123
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71477562
15Caffeine metabolism_Homo sapiens_hsa002321.66414894
16Nicotine addiction_Homo sapiens_hsa050331.61598256
17Linoleic acid metabolism_Homo sapiens_hsa005911.59147814
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55454825
19Nitrogen metabolism_Homo sapiens_hsa009101.53715386
20Parkinsons disease_Homo sapiens_hsa050121.51201640
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49887456
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36659500
23Peroxisome_Homo sapiens_hsa041461.33298117
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31421375
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26620366
26Tryptophan metabolism_Homo sapiens_hsa003801.23671454
27Huntingtons disease_Homo sapiens_hsa050161.21842119
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20316281
29Taste transduction_Homo sapiens_hsa047421.14773399
30Basal transcription factors_Homo sapiens_hsa030221.13587287
31Butanoate metabolism_Homo sapiens_hsa006501.13133574
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12358566
33* Viral carcinogenesis_Homo sapiens_hsa052031.11039779
34Morphine addiction_Homo sapiens_hsa050321.08275600
35Purine metabolism_Homo sapiens_hsa002301.05120533
36RNA degradation_Homo sapiens_hsa030181.04031071
37Ether lipid metabolism_Homo sapiens_hsa005651.01422259
38Cardiac muscle contraction_Homo sapiens_hsa042601.01075376
39Alzheimers disease_Homo sapiens_hsa050101.00200298
40Primary bile acid biosynthesis_Homo sapiens_hsa001200.99894030
41DNA replication_Homo sapiens_hsa030300.99191401
42Pyrimidine metabolism_Homo sapiens_hsa002400.97807316
43Steroid biosynthesis_Homo sapiens_hsa001000.96439017
44Sulfur relay system_Homo sapiens_hsa041220.95952024
45Nucleotide excision repair_Homo sapiens_hsa034200.92966897
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.92065788
47Fat digestion and absorption_Homo sapiens_hsa049750.91660628
48Cocaine addiction_Homo sapiens_hsa050300.89512720
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87411967
50Olfactory transduction_Homo sapiens_hsa047400.86603657
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86496136
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84576252
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84509976
54Basal cell carcinoma_Homo sapiens_hsa052170.79703579
55Non-homologous end-joining_Homo sapiens_hsa034500.79460912
56Glycerolipid metabolism_Homo sapiens_hsa005610.78731336
57One carbon pool by folate_Homo sapiens_hsa006700.74985355
58Base excision repair_Homo sapiens_hsa034100.74461126
59Protein export_Homo sapiens_hsa030600.74139103
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72622797
61Fatty acid biosynthesis_Homo sapiens_hsa000610.71971744
62Glutamatergic synapse_Homo sapiens_hsa047240.71832923
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71741329
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71290498
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69378759
66Amphetamine addiction_Homo sapiens_hsa050310.67795376
67Insulin secretion_Homo sapiens_hsa049110.66845063
68Hippo signaling pathway_Homo sapiens_hsa043900.66185950
69ABC transporters_Homo sapiens_hsa020100.65878270
70Mismatch repair_Homo sapiens_hsa034300.65516815
71RNA transport_Homo sapiens_hsa030130.65176517
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.63605132
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57671039
74Metabolic pathways_Homo sapiens_hsa011000.56109317
75GABAergic synapse_Homo sapiens_hsa047270.55055577
76Circadian entrainment_Homo sapiens_hsa047130.54898851
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54621112
78Arachidonic acid metabolism_Homo sapiens_hsa005900.54063187
79Vitamin digestion and absorption_Homo sapiens_hsa049770.52713788
80Fatty acid metabolism_Homo sapiens_hsa012120.52595659
81Retinol metabolism_Homo sapiens_hsa008300.51491668
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47794162
83Fatty acid degradation_Homo sapiens_hsa000710.47339895
84Chemical carcinogenesis_Homo sapiens_hsa052040.47066182
85Calcium signaling pathway_Homo sapiens_hsa040200.45914800
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43774355
87Hedgehog signaling pathway_Homo sapiens_hsa043400.40760591
88Collecting duct acid secretion_Homo sapiens_hsa049660.40274014
89Proteasome_Homo sapiens_hsa030500.40000196
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39815834
91Bile secretion_Homo sapiens_hsa049760.39168218
92Spliceosome_Homo sapiens_hsa030400.38780822
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37895046
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36647276
95Serotonergic synapse_Homo sapiens_hsa047260.35726379
96Axon guidance_Homo sapiens_hsa043600.33133068
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32178609
98Cholinergic synapse_Homo sapiens_hsa047250.32123713
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30824653
100Dopaminergic synapse_Homo sapiens_hsa047280.28460549

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