HIST1H4L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of histone H3-K9 methylation (GO:0051570)9.52622743
2innate immune response in mucosa (GO:0002227)8.56569014
3nucleosome assembly (GO:0006334)8.40948119
4nuclear pore complex assembly (GO:0051292)7.96514616
5protein-DNA complex assembly (GO:0065004)7.18086219
6nucleosome organization (GO:0034728)7.11003399
7antibacterial humoral response (GO:0019731)7.10723276
8mucosal immune response (GO:0002385)7.03986220
9nuclear pore organization (GO:0006999)7.00253724
10negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)6.51813455
11chromatin assembly (GO:0031497)6.46151889
12antimicrobial humoral response (GO:0019730)6.43637877
13organ or tissue specific immune response (GO:0002251)6.35461492
14protein-DNA complex subunit organization (GO:0071824)6.25300130
15pore complex assembly (GO:0046931)5.98505024
16chromatin assembly or disassembly (GO:0006333)5.55465647
17DNA unwinding involved in DNA replication (GO:0006268)5.48173632
18V(D)J recombination (GO:0033151)5.43636441
19CENP-A containing nucleosome assembly (GO:0034080)5.07173563
20chromatin remodeling at centromere (GO:0031055)4.91887982
21protein localization to chromosome, centromeric region (GO:0071459)4.77211981
22regulation of megakaryocyte differentiation (GO:0045652)4.76238530
23mitotic chromosome condensation (GO:0007076)4.68475484
24DNA strand elongation involved in DNA replication (GO:0006271)4.47970650
25DNA strand elongation (GO:0022616)4.43975592
26positive regulation of histone methylation (GO:0031062)4.41244189
27negative regulation of DNA repair (GO:0045738)4.33565237
28sister chromatid segregation (GO:0000819)4.25720910
29DNA replication initiation (GO:0006270)4.17121967
30DNA duplex unwinding (GO:0032508)4.13696257
31regulation of gene silencing (GO:0060968)4.10272417
32mitotic sister chromatid segregation (GO:0000070)4.05355670
33DNA geometric change (GO:0032392)4.00324635
34histone exchange (GO:0043486)3.88294654
35somatic cell DNA recombination (GO:0016444)3.83674817
36somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.83674817
37telomere maintenance via semi-conservative replication (GO:0032201)3.80184074
38somatic hypermutation of immunoglobulin genes (GO:0016446)3.79592091
39somatic diversification of immune receptors via somatic mutation (GO:0002566)3.79592091
40non-recombinational repair (GO:0000726)3.79460499
41double-strand break repair via nonhomologous end joining (GO:0006303)3.79460499
42DNA replication-independent nucleosome organization (GO:0034724)3.79371007
43DNA replication-independent nucleosome assembly (GO:0006336)3.79371007
44mitotic sister chromatid cohesion (GO:0007064)3.75398676
45histone lysine demethylation (GO:0070076)3.73091918
46DNA synthesis involved in DNA repair (GO:0000731)3.71115569
47telomere maintenance (GO:0000723)3.67452966
48telomere organization (GO:0032200)3.63922420
49protein localization to kinetochore (GO:0034501)3.62856862
50ATP-dependent chromatin remodeling (GO:0043044)3.61924912
51mitotic recombination (GO:0006312)3.60647158
52regulation of centrosome cycle (GO:0046605)3.60294326
53somatic diversification of immune receptors (GO:0002200)3.56616870
54telomere maintenance via recombination (GO:0000722)3.54773025
55histone demethylation (GO:0016577)3.51291378
56regulation of sister chromatid cohesion (GO:0007063)3.50368686
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.47828227
58regulation of centriole replication (GO:0046599)3.46510083
59regulation of centrosome duplication (GO:0010824)3.45717235
60meiotic chromosome segregation (GO:0045132)3.43031871
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.40518272
62kinetochore organization (GO:0051383)3.32428514
63pre-miRNA processing (GO:0031054)3.28665580
64DNA conformation change (GO:0071103)3.27032741
65regulation of sister chromatid segregation (GO:0033045)3.24722345
66regulation of mitotic sister chromatid separation (GO:0010965)3.24722345
67regulation of mitotic sister chromatid segregation (GO:0033047)3.24722345
68regulation of hematopoietic progenitor cell differentiation (GO:1901532)3.21514716
69DNA topological change (GO:0006265)3.21100123
70positive regulation of chromosome segregation (GO:0051984)3.20137443
71replicative senescence (GO:0090399)3.19823891
72positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.19468667
73positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.19468667
74positive regulation of mitotic sister chromatid separation (GO:1901970)3.19468667
75negative regulation of chromosome segregation (GO:0051985)3.19466163
76regulation of chromosome segregation (GO:0051983)3.19158626
77maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12937347
78regulation of histone methylation (GO:0031060)3.11497331
79protein demethylation (GO:0006482)3.11148992
80protein dealkylation (GO:0008214)3.11148992
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.10829912
82regulation of mitotic metaphase/anaphase transition (GO:0030071)3.10829912
83mitotic nuclear envelope disassembly (GO:0007077)3.08127156
84response to UV-C (GO:0010225)3.07041152
85negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04649541
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04649541
87negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04649541
88negative regulation of mitotic sister chromatid separation (GO:2000816)3.04649541
89negative regulation of sister chromatid segregation (GO:0033046)3.04649541
90negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.03116654
91peptidyl-lysine dimethylation (GO:0018027)3.03026874
92somatic recombination of immunoglobulin gene segments (GO:0016447)2.98481879
93T cell lineage commitment (GO:0002360)2.98471602
94positive regulation of cell cycle checkpoint (GO:1901978)2.96033602
95translesion synthesis (GO:0019985)2.95303787
96DNA ligation (GO:0006266)2.93341522
97mitotic spindle assembly checkpoint (GO:0007094)2.92933200
98positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.92354573
99DNA replication-dependent nucleosome assembly (GO:0006335)11.0445280
100DNA replication-dependent nucleosome organization (GO:0034723)11.0445280

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.70752990
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.29967948
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.55539260
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.30672055
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.16726279
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.84034869
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.66387170
8* SOX2_16153702_ChIP-ChIP_HESCs_Human2.52923750
9* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.42512646
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27107524
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16320956
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.04474375
13MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01156736
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse17.8435280
15RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.93875148
16GATA1_22025678_ChIP-Seq_K562_Human1.88337532
17CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.72733571
18SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.68553022
19HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.52268261
20EGR1_19374776_ChIP-ChIP_THP-1_Human1.48298584
21* NANOG_16153702_ChIP-ChIP_HESCs_Human1.37123090
22IRF1_19129219_ChIP-ChIP_H3396_Human1.35482657
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34457064
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33053673
25AR_21909140_ChIP-Seq_LNCAP_Human1.31145037
26HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29672889
27ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26333695
28ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25296695
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23465735
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20829530
31SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19166218
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15761103
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.11800103
34KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05053141
35TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03820434
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99449386
37ELK1_19687146_ChIP-ChIP_HELA_Human0.99131220
38ETS1_22383799_ChIP-Seq_G1ME_Mouse0.97707853
39PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97504939
40SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95059453
41ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94884879
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94820936
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94804439
44VDR_23849224_ChIP-Seq_CD4+_Human0.94320962
45MYC_22102868_ChIP-Seq_BL_Human0.89253834
46VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88377982
47TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87022470
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85878942
49STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85221192
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.85078196
51RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82481955
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.81909799
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80546479
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.80201826
55THAP11_20581084_ChIP-Seq_MESCs_Mouse0.75337009
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75066955
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.73284217
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.71540236
59MYC_18940864_ChIP-ChIP_HL60_Human0.70011891
60SALL4_22934838_ChIP-ChIP_CD34+_Human0.67698692
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.66614249
62BRD4_27068464_Chip-Seq_AML-cells_Mouse0.65843056
63KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.64543685
64NANOG_18555785_ChIP-Seq_MESCs_Mouse0.64101002
65FOXP3_21729870_ChIP-Seq_TREG_Human0.63587890
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.62421122
67ZFX_18555785_ChIP-Seq_MESCs_Mouse0.58516492
68E2F1_18555785_ChIP-Seq_MESCs_Mouse0.58394536
69CIITA_25753668_ChIP-Seq_RAJI_Human0.56655367
70MYC_19079543_ChIP-ChIP_MESCs_Mouse0.56042526
71MYC_18358816_ChIP-ChIP_MESCs_Mouse0.55762139
72SOX9_26525672_Chip-Seq_HEART_Mouse0.55350801
73VDR_21846776_ChIP-Seq_THP-1_Human0.54405239
74CREB1_15753290_ChIP-ChIP_HEK293T_Human0.54196565
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.52290127
76MYCN_18555785_ChIP-Seq_MESCs_Mouse0.50962716
77SOX17_20123909_ChIP-Seq_XEN_Mouse0.49844508
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.49789249
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.49389034
80MYB_26560356_Chip-Seq_TH1_Human0.48243238
81MAF_26560356_Chip-Seq_TH1_Human0.48059972
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.48054435
83POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.47492449
84ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.47344147
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.46723120
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.46061900
87TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.45812619
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.45031680
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.44425733
90SCL_19346495_ChIP-Seq_HPC-7_Human0.43690549
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.43238200
92GATA2_22383799_ChIP-Seq_G1ME_Mouse0.40586095
93PKCTHETA_26484144_Chip-Seq_BREAST_Human0.38860686
94GATA3_27048872_Chip-Seq_THYMUS_Human0.37865374
95NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.37746269
96ELF1_17652178_ChIP-ChIP_JURKAT_Human0.37497230
97SALL1_21062744_ChIP-ChIP_HESCs_Human0.37315165
98POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.37202055
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.37005018
100EST1_17652178_ChIP-ChIP_JURKAT_Human0.36466014

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.37852834
2MP0010094_abnormal_chromosome_stability5.30921347
3MP0003111_abnormal_nucleus_morphology4.17253136
4MP0002009_preneoplasia3.74615382
5MP0003077_abnormal_cell_cycle3.52629064
6MP0002396_abnormal_hematopoietic_system3.50499234
7MP0003693_abnormal_embryo_hatching3.47511422
8MP0010352_gastrointestinal_tract_polyps3.47008557
9MP0009697_abnormal_copulation3.31146573
10MP0004957_abnormal_blastocyst_morpholog3.27426945
11MP0010307_abnormal_tumor_latency2.73249125
12MP0003763_abnormal_thymus_physiology2.33342267
13MP0003705_abnormal_hypodermis_morpholog2.26873738
14MP0004381_abnormal_hair_follicle2.22847467
15MP0008058_abnormal_DNA_repair2.06559379
16MP0008932_abnormal_embryonic_tissue1.91367487
17MP0003786_premature_aging1.83618000
18MP0000350_abnormal_cell_proliferation1.81406513
19MP0005083_abnormal_biliary_tract1.80468241
20MP0002166_altered_tumor_susceptibility1.80081566
21MP0010234_abnormal_vibrissa_follicle1.79945313
22MP0004808_abnormal_hematopoietic_stem1.67743816
23MP0001730_embryonic_growth_arrest1.65858751
24MP0003941_abnormal_skin_development1.65787396
25MP0004185_abnormal_adipocyte_glucose1.65065578
26MP0008007_abnormal_cellular_replicative1.63553626
27MP0001661_extended_life_span1.62248893
28MP0000569_abnormal_digit_pigmentation1.58962929
29MP0002638_abnormal_pupillary_reflex1.57281492
30MP0005171_absent_coat_pigmentation1.51187510
31MP0000372_irregular_coat_pigmentation1.50251211
32MP0002006_tumorigenesis1.48033577
33MP0000703_abnormal_thymus_morphology1.44324386
34MP0002086_abnormal_extraembryonic_tissu1.36601548
35MP0005380_embryogenesis_phenotype1.36225018
36MP0001672_abnormal_embryogenesis/_devel1.36225018
37MP0003890_abnormal_embryonic-extraembry1.34367979
38MP0005075_abnormal_melanosome_morpholog1.32341123
39MP0002084_abnormal_developmental_patter1.31358834
40MP0003984_embryonic_growth_retardation1.30365072
41MP0000313_abnormal_cell_death1.27746624
42MP0002088_abnormal_embryonic_growth/wei1.23447923
43MP0005076_abnormal_cell_differentiation1.23339519
44MP0002019_abnormal_tumor_incidence1.22160533
45MP0000490_abnormal_crypts_of1.22057546
46MP0001697_abnormal_embryo_size1.21287111
47MP0002080_prenatal_lethality1.19740738
48MP0002398_abnormal_bone_marrow1.14873504
49MP0002085_abnormal_embryonic_tissue1.13500461
50MP0005220_abnormal_exocrine_pancreas1.10924303
51MP0002722_abnormal_immune_system1.08937993
52MP0002163_abnormal_gland_morphology1.07429910
53MP0002697_abnormal_eye_size1.04660283
54MP0009379_abnormal_foot_pigmentation1.01357734
55MP0003718_maternal_effect0.98167104
56MP0004197_abnormal_fetal_growth/weight/0.98129826
57MP0001849_ear_inflammation0.97809925
58MP0002877_abnormal_melanocyte_morpholog0.96855725
59MP0000015_abnormal_ear_pigmentation0.96036432
60MP0000358_abnormal_cell_content/0.94160807
61MP0000689_abnormal_spleen_morphology0.92206827
62MP0004147_increased_porphyrin_level0.91832445
63MP0001243_abnormal_dermal_layer0.91175345
64MP0001879_abnormal_lymphatic_vessel0.90848858
65MP0008877_abnormal_DNA_methylation0.89484460
66MP0001286_abnormal_eye_development0.86773780
67MP0001915_intracranial_hemorrhage0.84853768
68MP0002095_abnormal_skin_pigmentation0.82095893
69MP0006035_abnormal_mitochondrial_morpho0.81125561
70MP0000428_abnormal_craniofacial_morphol0.80639396
71MP0003656_abnormal_erythrocyte_physiolo0.79587913
72MP0005310_abnormal_salivary_gland0.77099558
73MP0001191_abnormal_skin_condition0.76474090
74MP0009672_abnormal_birth_weight0.75901686
75MP0005409_darkened_coat_color0.75515882
76MP0008770_decreased_survivor_rate0.73850149
77MP0010678_abnormal_skin_adnexa0.73407687
78MP0003937_abnormal_limbs/digits/tail_de0.73247920
79MP0003385_abnormal_body_wall0.72464752
80MP0002060_abnormal_skin_morphology0.71647762
81MP0002092_abnormal_eye_morphology0.70131054
82MP0000685_abnormal_immune_system0.68815223
83MP0004134_abnormal_chest_morphology0.68721643
84MP0005621_abnormal_cell_physiology0.68597870
85MP0003566_abnormal_cell_adhesion0.68453135
86MP0005384_cellular_phenotype0.68321245
87MP0003221_abnormal_cardiomyocyte_apopto0.67222641
88MP0002111_abnormal_tail_morphology0.66659213
89MP0004233_abnormal_muscle_weight0.65003025
90MP0001545_abnormal_hematopoietic_system0.64610588
91MP0005397_hematopoietic_system_phenotyp0.64610588
92MP0000537_abnormal_urethra_morphology0.64548020
93MP0001216_abnormal_epidermal_layer0.64543494
94MP0000377_abnormal_hair_follicle0.63607567
95MP0002075_abnormal_coat/hair_pigmentati0.63355242
96MP0000465_gastrointestinal_hemorrhage0.63086886
97MP0003868_abnormal_feces_composition0.62080949
98MP0002429_abnormal_blood_cell0.61973041
99MP0006072_abnormal_retinal_apoptosis0.61569861
100MP0000371_diluted_coat_color0.60686208

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.37714352
2Chromsome breakage (HP:0040012)5.73581429
3B lymphocytopenia (HP:0010976)4.76389153
4Medulloblastoma (HP:0002885)4.71671383
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.16872454
6Short 4th metacarpal (HP:0010044)4.16872454
7Abnormality of chromosome stability (HP:0003220)4.04481588
8IgA deficiency (HP:0002720)4.04367755
9Abnormality of B cell number (HP:0010975)4.03731767
10IgM deficiency (HP:0002850)3.92730671
11Thyroiditis (HP:0100646)3.91633502
12Nephroblastoma (Wilms tumor) (HP:0002667)3.91333754
13Colitis (HP:0002583)3.71359315
14Embryonal renal neoplasm (HP:0011794)3.67990476
15Aplasia/Hypoplasia of the uvula (HP:0010293)3.36316308
16Abnormality of the preputium (HP:0100587)3.25868464
17Neoplasm of the oral cavity (HP:0100649)3.07348644
18Meckel diverticulum (HP:0002245)3.02761491
19Neoplasm of striated muscle (HP:0009728)3.02388082
20Combined immunodeficiency (HP:0005387)2.98940673
21Abnormality of the ileum (HP:0001549)2.94224467
22Abnormality of the carotid arteries (HP:0005344)2.92657361
23Abnormality of the 4th metacarpal (HP:0010012)2.80070976
24Neoplasm of the heart (HP:0100544)2.76361269
25Severe combined immunodeficiency (HP:0004430)2.75431757
26Myelodysplasia (HP:0002863)2.74905570
27Small intestinal stenosis (HP:0012848)2.74661622
28Duodenal stenosis (HP:0100867)2.74661622
29Orthostatic hypotension (HP:0001278)2.73891047
30Asymmetry of the thorax (HP:0001555)2.70140527
31Acute lymphatic leukemia (HP:0006721)2.65995878
32Basal cell carcinoma (HP:0002671)2.65824576
33Skull defect (HP:0001362)2.59663589
34Colon cancer (HP:0003003)2.56289974
35Panhypogammaglobulinemia (HP:0003139)2.52604457
36Clubbing of toes (HP:0100760)2.42913198
37Cafe-au-lait spot (HP:0000957)2.40466585
38Recurrent viral infections (HP:0004429)2.39496869
39Abnormality of the distal phalanx of the thumb (HP:0009617)2.38636278
40Rhabdomyosarcoma (HP:0002859)2.37246564
41Abnormality of the parietal bone (HP:0002696)2.34879333
42Sandal gap (HP:0001852)2.33609016
43Abnormality of the duodenum (HP:0002246)2.32542567
44Embryonal neoplasm (HP:0002898)2.32036944
45Abnormality of the fingertips (HP:0001211)2.24200585
46Autoimmune hemolytic anemia (HP:0001890)2.23580101
47Broad ribs (HP:0000885)2.23432336
48Arteriovenous malformation (HP:0100026)2.20852059
49Ependymoma (HP:0002888)2.20749065
50Cellulitis (HP:0100658)2.20205267
51Down-sloping shoulders (HP:0200021)2.19066863
52Hypoplasia of the thymus (HP:0000778)2.14025351
53Neoplasm of the adrenal cortex (HP:0100641)2.13273823
54Carpal bone hypoplasia (HP:0001498)2.11064747
55Abnormality of chromosome segregation (HP:0002916)2.10493467
56Spontaneous hematomas (HP:0007420)2.08562333
57Lymphoma (HP:0002665)2.07738460
58Milia (HP:0001056)2.07183460
59Short thumb (HP:0009778)2.06953053
60Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.06189064
61Ectopic kidney (HP:0000086)2.02368650
62Acute myeloid leukemia (HP:0004808)1.99300250
6311 pairs of ribs (HP:0000878)1.99073786
64High anterior hairline (HP:0009890)1.97840355
65Selective tooth agenesis (HP:0001592)1.97587772
66Cellular immunodeficiency (HP:0005374)1.97551620
67Intestinal polyp (HP:0005266)1.95570552
68Sloping forehead (HP:0000340)1.94162737
69Reticulocytopenia (HP:0001896)1.93867318
70Malignant neoplasm of the central nervous system (HP:0100836)1.93531295
71Deep philtrum (HP:0002002)1.90879734
72Cortical dysplasia (HP:0002539)1.89962765
73Poikilocytosis (HP:0004447)1.87663290
74Deep palmar crease (HP:0006191)1.86820652
75Short phalanx of the thumb (HP:0009660)1.85230235
76Abnormality of the renal collecting system (HP:0004742)1.83875441
77T lymphocytopenia (HP:0005403)1.83580501
78Gastrointestinal carcinoma (HP:0002672)1.83171546
79Malignant gastrointestinal tract tumors (HP:0006749)1.83171546
80Ovarian neoplasm (HP:0100615)1.83141124
81Inflammation of the large intestine (HP:0002037)1.82500644
82Prostate neoplasm (HP:0100787)1.80937046
83Prominent nose (HP:0000448)1.80255915
84Acanthocytosis (HP:0001927)1.80115648
85Squamous cell carcinoma (HP:0002860)1.79845088
86Duplicated collecting system (HP:0000081)1.79670968
87Agammaglobulinemia (HP:0004432)1.79452490
88Thyroid carcinoma (HP:0002890)1.78964587
89Abnormality of the astrocytes (HP:0100707)1.78140019
90Astrocytoma (HP:0009592)1.78140019
91Abnormality of DNA repair (HP:0003254)1.77261082
92Oral leukoplakia (HP:0002745)1.75669337
93Spinal muscular atrophy (HP:0007269)1.75461001
94Hepatoblastoma (HP:0002884)1.75128987
95Glioma (HP:0009733)1.72946891
96High pitched voice (HP:0001620)1.72263493
97Deformed sella turcica (HP:0002681)1.72098521
98Diastasis recti (HP:0001540)1.71355251
99Gastrointestinal inflammation (HP:0004386)1.70229880
100Birth length less than 3rd percentile (HP:0003561)1.69459839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK9.27302479
2TLK18.58231724
3VRK15.20753325
4RPS6KA53.34998226
5STK42.66867758
6DAPK32.63548442
7MAP3K102.46243871
8CDC71.97512378
9SCYL21.86268813
10TAF11.76217063
11AURKA1.59791304
12AURKB1.44674875
13SMG11.41640669
14PIM11.38506871
15TTK1.37658512
16CHEK21.36489648
17PLK41.32584906
18SRPK11.20359624
19BUB11.19101419
20NLK1.18837590
21MAP3K81.13973141
22PKN11.12701157
23TIE11.03294107
24EIF2AK31.00708108
25RPS6KB20.90121490
26TSSK60.84110122
27ATR0.84030312
28EEF2K0.80595190
29BTK0.80501686
30MAP3K40.78842010
31CDK40.68138521
32BRD40.66636791
33PRKAA10.65043881
34MELK0.63510206
35BRSK20.61819069
36CDK60.60730794
37MAP2K70.60218519
38PLK10.60186085
39NEK10.60132176
40CDK70.58015498
41ICK0.57816830
42CDK80.57255634
43ATM0.55073817
44PRPF4B0.54249613
45CDK120.53756723
46NEK20.53185160
47TEC0.50750924
48CCNB10.49393158
49CAMK40.47580348
50CHEK10.46898036
51AKT20.44199022
52BRAF0.41598405
53PRKCQ0.39410222
54ACVR1B0.38606517
55MAPK110.36853541
56PBK0.36847354
57WEE10.35835280
58PLK30.33893663
59CDK20.32916390
60TRIB30.31984984
61RPS6KA40.31221819
62EPHA30.31054933
63JAK20.29974810
64MAP2K40.29403591
65RPS6KB10.27809429
66NEK90.26369295
67CAMK1D0.25374139
68MAP2K30.25273899
69MKNK20.24852979
70SYK0.23706860
71CDK10.23630168
72BMPR1B0.22233544
73EIF2AK20.21008952
74CSNK1G10.19945731
75SGK10.18957160
76STK240.18901026
77STK30.18282283
78PKN20.18235776
79TRPM70.18018407
80TTN0.17981021
81NUAK10.16136113
82PDGFRA0.15268094
83PRKDC0.15195919
84RPS6KL10.14391135
85RPS6KC10.14391135
86RPS6KA30.13375962
87RET0.12150103
88AKT10.11626625
89CSNK1G30.11033556
90CDK90.10241087
91MAPK90.10181276
92CLK10.10138693
93CSNK2A20.09177845
94MST40.09143051
95CSNK1A1L0.08954486
96PIK3CG0.08939058
97PAK10.08744056
98MTOR0.08147226
99MAPK140.07568471
100GSK3B0.07074086

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050348.51402489
2* Viral carcinogenesis_Homo sapiens_hsa052033.88212169
3DNA replication_Homo sapiens_hsa030302.44399887
4Transcriptional misregulation in cancer_Homo sapiens_hsa052022.05292025
5* Systemic lupus erythematosus_Homo sapiens_hsa0532211.6310685
6Mismatch repair_Homo sapiens_hsa034301.76829989
7Cell cycle_Homo sapiens_hsa041101.71371693
8Non-homologous end-joining_Homo sapiens_hsa034501.64308877
9Fanconi anemia pathway_Homo sapiens_hsa034601.46147203
10Homologous recombination_Homo sapiens_hsa034401.36155187
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15082131
12Base excision repair_Homo sapiens_hsa034101.04634921
13Nucleotide excision repair_Homo sapiens_hsa034200.99028021
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92123501
15Primary immunodeficiency_Homo sapiens_hsa053400.87899163
16Non-small cell lung cancer_Homo sapiens_hsa052230.81801349
17Thyroid cancer_Homo sapiens_hsa052160.80975716
18Chronic myeloid leukemia_Homo sapiens_hsa052200.75078900
19p53 signaling pathway_Homo sapiens_hsa041150.70748006
20RNA transport_Homo sapiens_hsa030130.70698997
21MicroRNAs in cancer_Homo sapiens_hsa052060.70107591
22Glioma_Homo sapiens_hsa052140.68633521
23Pancreatic cancer_Homo sapiens_hsa052120.67372338
24Small cell lung cancer_Homo sapiens_hsa052220.62963253
25mRNA surveillance pathway_Homo sapiens_hsa030150.60127642
26Spliceosome_Homo sapiens_hsa030400.59777855
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58385898
28One carbon pool by folate_Homo sapiens_hsa006700.58140322
29Colorectal cancer_Homo sapiens_hsa052100.54807355
30Selenocompound metabolism_Homo sapiens_hsa004500.54315764
31Prostate cancer_Homo sapiens_hsa052150.54263219
32B cell receptor signaling pathway_Homo sapiens_hsa046620.53585561
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49573658
34Bladder cancer_Homo sapiens_hsa052190.48404436
35HTLV-I infection_Homo sapiens_hsa051660.46193910
36Pyrimidine metabolism_Homo sapiens_hsa002400.43708294
37Hepatitis B_Homo sapiens_hsa051610.41955466
38Lysine degradation_Homo sapiens_hsa003100.40280713
39Melanoma_Homo sapiens_hsa052180.40216172
40Inositol phosphate metabolism_Homo sapiens_hsa005620.39011112
41Basal cell carcinoma_Homo sapiens_hsa052170.38132936
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36843648
43Ribosome_Homo sapiens_hsa030100.36047783
44Endometrial cancer_Homo sapiens_hsa052130.35439554
45Oocyte meiosis_Homo sapiens_hsa041140.32996510
46TGF-beta signaling pathway_Homo sapiens_hsa043500.32726903
47Acute myeloid leukemia_Homo sapiens_hsa052210.31360601
48Epstein-Barr virus infection_Homo sapiens_hsa051690.30056123
49Renin-angiotensin system_Homo sapiens_hsa046140.28858774
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28846056
51Basal transcription factors_Homo sapiens_hsa030220.28155601
52Apoptosis_Homo sapiens_hsa042100.25516378
53RNA degradation_Homo sapiens_hsa030180.25153418
54Hematopoietic cell lineage_Homo sapiens_hsa046400.24887805
55Measles_Homo sapiens_hsa051620.22570511
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20942718
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20473143
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.20016524
59Herpes simplex infection_Homo sapiens_hsa051680.19446759
60ErbB signaling pathway_Homo sapiens_hsa040120.19430888
61Pathways in cancer_Homo sapiens_hsa052000.19178100
62Purine metabolism_Homo sapiens_hsa002300.18716303
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18694191
64FoxO signaling pathway_Homo sapiens_hsa040680.18473253
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17471310
66T cell receptor signaling pathway_Homo sapiens_hsa046600.17415549
67RNA polymerase_Homo sapiens_hsa030200.16190118
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15564451
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.14691111
70Proteoglycans in cancer_Homo sapiens_hsa052050.14621764
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.14100157
72Wnt signaling pathway_Homo sapiens_hsa043100.13445788
73Hedgehog signaling pathway_Homo sapiens_hsa043400.13149778
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12485287
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.11963227
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11644271
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.11170941
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.10730324
79mTOR signaling pathway_Homo sapiens_hsa041500.10486669
80Adherens junction_Homo sapiens_hsa045200.10291726
81Pentose phosphate pathway_Homo sapiens_hsa000300.09743134
82Prolactin signaling pathway_Homo sapiens_hsa049170.08804890
83Platelet activation_Homo sapiens_hsa046110.08491359
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08446771
85Fatty acid biosynthesis_Homo sapiens_hsa000610.06792551
86HIF-1 signaling pathway_Homo sapiens_hsa040660.06781752
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05841280
88Biosynthesis of amino acids_Homo sapiens_hsa012300.04916895
89Hippo signaling pathway_Homo sapiens_hsa043900.04674942
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.04366221
91N-Glycan biosynthesis_Homo sapiens_hsa005100.03777410
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.01127255
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.01033041
94Influenza A_Homo sapiens_hsa051640.00931718
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.00196850
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.00077790
97Citrate cycle (TCA cycle)_Homo sapiens_hsa00020-0.0176182
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0133914
99Gap junction_Homo sapiens_hsa04540-0.0017891
100AMPK signaling pathway_Homo sapiens_hsa04152-0.0017160

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