HIST1H4C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)9.11390054
2DNA replication-dependent nucleosome organization (GO:0034723)9.11390054
3chromatin assembly (GO:0031497)8.28076317
4regulation of histone H3-K9 methylation (GO:0051570)7.61825563
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.46944851
6nucleosome assembly (GO:0006334)7.11555687
7ATP synthesis coupled proton transport (GO:0015986)6.44341613
8energy coupled proton transport, down electrochemical gradient (GO:0015985)6.44341613
9nuclear pore complex assembly (GO:0051292)6.38479565
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.18920728
11nucleosome organization (GO:0034728)6.16007350
12cotranslational protein targeting to membrane (GO:0006613)6.15226265
13nuclear pore organization (GO:0006999)6.08449993
14protein targeting to ER (GO:0045047)6.06459832
15mitotic chromosome condensation (GO:0007076)5.99618819
16protein-DNA complex assembly (GO:0065004)5.96288003
17chromatin assembly or disassembly (GO:0006333)5.86495718
18antibacterial humoral response (GO:0019731)5.83150480
19establishment of protein localization to endoplasmic reticulum (GO:0072599)5.81616866
20ribosomal small subunit biogenesis (GO:0042274)5.80508672
21DNA unwinding involved in DNA replication (GO:0006268)5.75802661
22cellular protein complex disassembly (GO:0043624)5.71727082
23protein localization to endoplasmic reticulum (GO:0070972)5.59137887
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.44963009
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.42594772
26innate immune response in mucosa (GO:0002227)5.42467328
27antimicrobial humoral response (GO:0019730)5.42451296
28maturation of SSU-rRNA (GO:0030490)5.42445171
29viral life cycle (GO:0019058)5.37839223
30protein-DNA complex subunit organization (GO:0071824)5.34331917
31establishment of protein localization to mitochondrial membrane (GO:0090151)5.30204060
32protein localization to kinetochore (GO:0034501)5.22036835
33respiratory electron transport chain (GO:0022904)5.18239491
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.15531497
35electron transport chain (GO:0022900)5.06122576
36chaperone-mediated protein transport (GO:0072321)5.05685129
37protein complex disassembly (GO:0043241)4.91419372
38translational initiation (GO:0006413)4.91407444
39sister chromatid segregation (GO:0000819)4.91177585
40pore complex assembly (GO:0046931)4.88987161
41protein localization to chromosome, centromeric region (GO:0071459)4.72629081
42macromolecular complex disassembly (GO:0032984)4.61041904
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.50216769
44mitochondrial respiratory chain complex I assembly (GO:0032981)4.50216769
45NADH dehydrogenase complex assembly (GO:0010257)4.50216769
46protein complex biogenesis (GO:0070271)4.48817426
47folic acid-containing compound biosynthetic process (GO:0009396)4.35858931
48chromosome condensation (GO:0030261)4.28770230
49kinetochore assembly (GO:0051382)4.27647577
50mitochondrial respiratory chain complex assembly (GO:0033108)4.24941908
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.23259330
52microtubule depolymerization (GO:0007019)4.20890709
53negative regulation of histone methylation (GO:0031061)4.17736061
54mucosal immune response (GO:0002385)4.13290805
55chromatin remodeling at centromere (GO:0031055)4.13290244
56ribosomal large subunit biogenesis (GO:0042273)4.08250588
57sequestering of actin monomers (GO:0042989)4.05596824
58mitotic sister chromatid segregation (GO:0000070)4.05187156
59CENP-A containing nucleosome assembly (GO:0034080)4.04588271
60DNA duplex unwinding (GO:0032508)4.02478117
61DNA geometric change (GO:0032392)4.01210475
62inner mitochondrial membrane organization (GO:0007007)3.99095935
63protein targeting to membrane (GO:0006612)3.98744096
64mitotic nuclear envelope disassembly (GO:0007077)3.98053648
65translation (GO:0006412)3.97929557
66nuclear-transcribed mRNA catabolic process (GO:0000956)3.95311687
67organ or tissue specific immune response (GO:0002251)3.89559332
68protein K6-linked ubiquitination (GO:0085020)3.88008514
69DNA replication initiation (GO:0006270)3.87834918
70mitotic sister chromatid cohesion (GO:0007064)3.87608683
71proteasome assembly (GO:0043248)3.87538287
72translesion synthesis (GO:0019985)3.84143063
73dosage compensation (GO:0007549)3.82257126
74membrane disassembly (GO:0030397)3.81262977
75nuclear envelope disassembly (GO:0051081)3.81262977
76regulation of centriole replication (GO:0046599)3.80943716
77DNA packaging (GO:0006323)3.78647581
78protein neddylation (GO:0045116)3.76897784
79mRNA catabolic process (GO:0006402)3.74129649
80DNA topological change (GO:0006265)3.72925167
81spliceosomal snRNP assembly (GO:0000387)3.72492912
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.70157662
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.70157662
84positive regulation of mitotic sister chromatid separation (GO:1901970)3.70157662
85positive regulation of chromosome segregation (GO:0051984)3.68086949
86regulation of gene silencing (GO:0060968)3.67399269
87regulation of translational fidelity (GO:0006450)3.65578488
88DNA replication-independent nucleosome organization (GO:0034724)3.65472461
89DNA replication-independent nucleosome assembly (GO:0006336)3.65472461
90regulation of sister chromatid cohesion (GO:0007063)3.65025977
91DNA replication checkpoint (GO:0000076)3.63927054
92DNA strand elongation involved in DNA replication (GO:0006271)3.61995062
93histone exchange (GO:0043486)3.58536443
94mitotic recombination (GO:0006312)3.57811862
95DNA ligation (GO:0006266)3.56359335
96DNA conformation change (GO:0071103)3.53744322
97ribosomal small subunit assembly (GO:0000028)3.51303853
98IMP biosynthetic process (GO:0006188)3.50505227
99spliceosomal complex assembly (GO:0000245)3.50040325
100regulation of mitochondrial translation (GO:0070129)3.50014899
101establishment of integrated proviral latency (GO:0075713)3.46006674
102regulation of RNA export from nucleus (GO:0046831)3.44976002
103mitotic G1 DNA damage checkpoint (GO:0031571)3.44593762
104ATP biosynthetic process (GO:0006754)3.43741706
105RNA catabolic process (GO:0006401)3.43490085
106positive regulation of histone methylation (GO:0031062)3.41905110
107DNA strand elongation (GO:0022616)3.40044962
108nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38597805
109telomere maintenance via semi-conservative replication (GO:0032201)3.37507451
110regulation of centrosome cycle (GO:0046605)3.36424597
111viral transcription (GO:0019083)3.32952730
112transcription elongation from RNA polymerase III promoter (GO:0006385)3.31810342
113termination of RNA polymerase III transcription (GO:0006386)3.31810342
114purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.29477816
115purine nucleoside triphosphate biosynthetic process (GO:0009145)3.29286463
116attachment of spindle microtubules to kinetochore (GO:0008608)3.27825877
117DNA synthesis involved in DNA repair (GO:0000731)3.27568061
118exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27497008
119translational termination (GO:0006415)3.26517363
120regulation of DNA endoreduplication (GO:0032875)3.23905728
121postreplication repair (GO:0006301)3.23253165
122negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.22067224
123DNA damage response, detection of DNA damage (GO:0042769)3.20427518
124meiotic chromosome segregation (GO:0045132)3.16978420
125regulation of chromosome segregation (GO:0051983)3.16563270
126positive regulation of gastrulation (GO:2000543)3.14698129
127IMP metabolic process (GO:0046040)3.13634537
128monoubiquitinated protein deubiquitination (GO:0035520)3.11967853
129telomere maintenance via recombination (GO:0000722)3.11893273
130negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.11604211
131histone lysine demethylation (GO:0070076)3.11078416
132ATP-dependent chromatin remodeling (GO:0043044)3.10498700
133centriole replication (GO:0007099)3.10458004
134regulation of spindle organization (GO:0090224)3.10153670
135kinetochore organization (GO:0051383)3.09954556
136protein localization to chromosome (GO:0034502)3.08228618
137hydrogen ion transmembrane transport (GO:1902600)3.05989534
138histone demethylation (GO:0016577)3.05786694
139midbrain development (GO:0030901)3.05780067
140regulation of centrosome duplication (GO:0010824)3.04931237
141mitotic metaphase plate congression (GO:0007080)3.04692822
142anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00404809
143translational elongation (GO:0006414)2.98995227
144cellular component biogenesis (GO:0044085)2.98092689
145ribonucleoside triphosphate biosynthetic process (GO:0009201)2.97672297
146G1 DNA damage checkpoint (GO:0044783)2.95554847
147microtubule polymerization or depolymerization (GO:0031109)2.95469697
148regulation of histone methylation (GO:0031060)2.95432663
149mitotic G1/S transition checkpoint (GO:0044819)2.93276477
150cellular hyperosmotic response (GO:0071474)2.93259520
151regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92676310
152nuclear envelope organization (GO:0006998)2.91773516
153negative regulation of ligase activity (GO:0051352)2.89428206
154negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89428206
155chromosome segregation (GO:0007059)2.89337908
156regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89298614
157regulation of mitotic spindle checkpoint (GO:1903504)2.89298614
158response to UV-C (GO:0010225)2.88925636
159peptidyl-lysine dimethylation (GO:0018027)2.88874190
160resolution of meiotic recombination intermediates (GO:0000712)2.88855972
161telomere maintenance (GO:0000723)2.88686212
162spindle checkpoint (GO:0031577)2.88515504
163mitotic DNA integrity checkpoint (GO:0044774)2.88424442
164negative regulation of DNA repair (GO:0045738)2.87099700
165nucleotide-excision repair, DNA gap filling (GO:0006297)2.86279606
166regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85457947
167telomere organization (GO:0032200)2.84337395
168GTP biosynthetic process (GO:0006183)2.84308831
169mitotic G2/M transition checkpoint (GO:0044818)2.81396796
170metaphase plate congression (GO:0051310)2.77506652
171ribonucleoprotein complex biogenesis (GO:0022613)2.76339556
172positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75451810
173nucleoside triphosphate biosynthetic process (GO:0009142)2.74811292
174protein targeting to mitochondrion (GO:0006626)2.66292405
175establishment of viral latency (GO:0019043)2.66072288

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.83007761
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.98587193
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.83628882
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.13786655
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.00213884
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.76517954
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.17401040
8* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.00599703
9* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.65736526
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.54167397
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48009730
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41502082
13* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.21638711
14* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19121587
15MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12452797
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse17.1639235
17* E2F1_21310950_ChIP-Seq_MCF-7_Human1.88663111
18TP63_19390658_ChIP-ChIP_HaCaT_Human1.87410345
19* SOX2_16153702_ChIP-ChIP_HESCs_Human1.76801529
20* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.76553711
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75155501
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.71957890
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.68140077
24EWS_26573619_Chip-Seq_HEK293_Human1.66088575
25DCP1A_22483619_ChIP-Seq_HELA_Human1.63597304
26* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62449278
27* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.57192323
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53892720
29FUS_26573619_Chip-Seq_HEK293_Human1.53691384
30ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49853442
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.48946132
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48656773
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.47453096
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.44961106
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44354887
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43961703
37VDR_22108803_ChIP-Seq_LS180_Human1.42196744
38EZH2_22144423_ChIP-Seq_EOC_Human1.40377129
39SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38136583
40HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.36624575
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36465443
42* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33003660
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31984833
44* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27379252
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26346210
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25221148
47KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25031141
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24841940
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22260659
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.21773310
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21647836
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20798215
53* VDR_23849224_ChIP-Seq_CD4+_Human1.19872974
54* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19344143
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16542478
56ZNF274_21170338_ChIP-Seq_K562_Hela1.15971766
57ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15971603
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15735620
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14867675
60* AR_21909140_ChIP-Seq_LNCAP_Human1.13255824
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11711844
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08294720
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06465056
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06155727
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05973919
66* ELK1_19687146_ChIP-ChIP_HELA_Human1.05003486
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04086763
68GABP_19822575_ChIP-Seq_HepG2_Human1.03982543
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03933841
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.03824773
71MYC_22102868_ChIP-Seq_BL_Human1.03791273
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00177115
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98588259
74ELK1_22589737_ChIP-Seq_MCF10A_Human0.98534277
75* NANOG_16153702_ChIP-ChIP_HESCs_Human0.97011924
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95197500
77PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94453628
78CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94296785
79* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93542551
80STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93018539
81* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91784323
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91443475
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90761146
84* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90698782
85EZH2_27304074_Chip-Seq_ESCs_Mouse0.87477031
86ETS1_22383799_ChIP-Seq_G1ME_Mouse0.86727526
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86645614
88CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83849208
89LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83834890
90MYC_18358816_ChIP-ChIP_MESCs_Mouse0.83573623
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83152240
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82721591
93TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82410035
94* FOXP3_21729870_ChIP-Seq_TREG_Human0.82049728
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81930252
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81930252
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81930252
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81903775
99VDR_21846776_ChIP-Seq_THP-1_Human0.80584393
100SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78143123
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77642829
102* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.77477487
103XRN2_22483619_ChIP-Seq_HELA_Human0.77388384
104HTT_18923047_ChIP-ChIP_STHdh_Human0.77172593
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.76901457
106RNF2_27304074_Chip-Seq_NSC_Mouse0.76611021
107MYCN_18555785_ChIP-Seq_MESCs_Mouse0.75799529
108GATA1_22025678_ChIP-Seq_K562_Human0.75687144
109ZFX_18555785_ChIP-Seq_MESCs_Mouse0.74709751
110P300_19829295_ChIP-Seq_ESCs_Human0.73756090
111* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.73059183
112TAF15_26573619_Chip-Seq_HEK293_Human0.72858506
113* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72251451
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.71312182
115TP53_22573176_ChIP-Seq_HFKS_Human0.70515640
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.70447700
117CREB1_15753290_ChIP-ChIP_HEK293T_Human0.70424582
118NANOG_18555785_ChIP-Seq_MESCs_Mouse0.69998717
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.68697092
120YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.68158868
121IRF1_19129219_ChIP-ChIP_H3396_Human0.67434505
122KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.66789525
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.66225251
124SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.66157484
125TCF3_18692474_ChIP-Seq_MEFs_Mouse0.65968189
126SOX17_20123909_ChIP-Seq_XEN_Mouse0.65949635
127GATA2_22383799_ChIP-Seq_G1ME_Mouse0.65253889
128IGF1R_20145208_ChIP-Seq_DFB_Human0.65253082
129HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.62979246
130SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.61604784
131MYC_18940864_ChIP-ChIP_HL60_Human0.59214939
132KDM5A_27292631_Chip-Seq_BREAST_Human0.59047310
133DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.58814732
134UTX_26944678_Chip-Seq_JUKART_Human0.56877509
135CIITA_25753668_ChIP-Seq_RAJI_Human0.56122809
136THAP11_20581084_ChIP-Seq_MESCs_Mouse0.55146947
137* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.54816308
138MAF_26560356_Chip-Seq_TH1_Human0.54661818
139ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.54254232
140SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.54247719
141TCF7_22412390_ChIP-Seq_EML_Mouse0.52824099
142* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.52656264
143GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.52379905
144NANOG_21062744_ChIP-ChIP_HESCs_Human0.51943404
145MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.51728188
146EST1_17652178_ChIP-ChIP_JURKAT_Human0.49861783
147STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.49755838
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.49721501
149TTF2_22483619_ChIP-Seq_HELA_Human0.49706687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.32134183
2MP0010094_abnormal_chromosome_stability4.60031883
3MP0006292_abnormal_olfactory_placode4.17243120
4MP0010307_abnormal_tumor_latency3.97867202
5MP0003111_abnormal_nucleus_morphology3.58695388
6MP0000566_synostosis3.51132359
7MP0010030_abnormal_orbit_morphology3.37560315
8MP0003077_abnormal_cell_cycle3.31228189
9MP0010352_gastrointestinal_tract_polyps3.20163123
10MP0003693_abnormal_embryo_hatching3.10084958
11MP0008057_abnormal_DNA_replication2.87263179
12MP0003705_abnormal_hypodermis_morpholog2.84011089
13MP0010234_abnormal_vibrissa_follicle2.83269464
14MP0002938_white_spotting2.78493741
15MP0004957_abnormal_blastocyst_morpholog2.68621075
16MP0006054_spinal_hemorrhage2.42163764
17MP0002877_abnormal_melanocyte_morpholog2.30872469
18MP0008007_abnormal_cellular_replicative2.29558179
19MP0000372_irregular_coat_pigmentation2.22683695
20MP0004808_abnormal_hematopoietic_stem2.13878627
21MP0008877_abnormal_DNA_methylation2.10823707
22MP0008058_abnormal_DNA_repair2.08000589
23MP0003283_abnormal_digestive_organ2.04923755
24MP0005076_abnormal_cell_differentiation2.01754197
25MP0000350_abnormal_cell_proliferation1.98465133
26MP0002234_abnormal_pharynx_morphology1.97777009
27MP0002277_abnormal_respiratory_mucosa1.96444359
28MP0001730_embryonic_growth_arrest1.95540895
29MP0001529_abnormal_vocalization1.93846750
30MP0005171_absent_coat_pigmentation1.92044543
31MP0008932_abnormal_embryonic_tissue1.83985797
32MP0002166_altered_tumor_susceptibility1.74887431
33MP0002653_abnormal_ependyma_morphology1.74473700
34MP0002102_abnormal_ear_morphology1.71780908
35MP0002009_preneoplasia1.69277246
36MP0003123_paternal_imprinting1.64486618
37MP0004197_abnormal_fetal_growth/weight/1.63858442
38MP0003121_genomic_imprinting1.63523320
39MP0001485_abnormal_pinna_reflex1.62727752
40MP0004142_abnormal_muscle_tone1.60825861
41MP0000371_diluted_coat_color1.60139973
42MP0000631_abnormal_neuroendocrine_gland1.59986817
43MP0003938_abnormal_ear_development1.58998782
44MP0003941_abnormal_skin_development1.56232089
45MP0002396_abnormal_hematopoietic_system1.56228994
46MP0008789_abnormal_olfactory_epithelium1.52712683
47MP0002095_abnormal_skin_pigmentation1.51642487
48MP0005084_abnormal_gallbladder_morpholo1.51003096
49MP0003300_gastrointestinal_ulcer1.50970682
50MP0000490_abnormal_crypts_of1.50209110
51MP0005408_hypopigmentation1.48786320
52MP0000049_abnormal_middle_ear1.46631541
53MP0000569_abnormal_digit_pigmentation1.46579636
54MP0002086_abnormal_extraembryonic_tissu1.45002505
55MP0004133_heterotaxia1.43018508
56MP0001697_abnormal_embryo_size1.41325193
57MP0001293_anophthalmia1.40280181
58MP0002019_abnormal_tumor_incidence1.39474246
59MP0003718_maternal_effect1.38745611
60MP0002736_abnormal_nociception_after1.36890802
61MP0006072_abnormal_retinal_apoptosis1.34065683
62MP0003011_delayed_dark_adaptation1.33516665
63MP0002080_prenatal_lethality1.33416376
64MP0003786_premature_aging1.32901250
65MP0001672_abnormal_embryogenesis/_devel1.31340874
66MP0005380_embryogenesis_phenotype1.31340874
67MP0003656_abnormal_erythrocyte_physiolo1.30801324
68MP0002006_tumorigenesis1.29544239
69MP0002084_abnormal_developmental_patter1.28741830
70MP0000579_abnormal_nail_morphology1.26298387
71MP0000703_abnormal_thymus_morphology1.26120802
72MP0002092_abnormal_eye_morphology1.25619136
73MP0005410_abnormal_fertilization1.25079114
74MP0000733_abnormal_muscle_development1.24717807
75MP0002075_abnormal_coat/hair_pigmentati1.24694191
76MP0002085_abnormal_embryonic_tissue1.24177485
77MP0001346_abnormal_lacrimal_gland1.23773104
78MP0002697_abnormal_eye_size1.22752517
79MP0000537_abnormal_urethra_morphology1.21773881
80MP0003315_abnormal_perineum_morphology1.16899086
81MP0003186_abnormal_redox_activity1.16674121
82MP0000778_abnormal_nervous_system1.16581801
83MP0005394_taste/olfaction_phenotype1.14262635
84MP0005499_abnormal_olfactory_system1.14262635
85MP0003984_embryonic_growth_retardation1.12904230
86MP0002088_abnormal_embryonic_growth/wei1.11859435
87MP0002398_abnormal_bone_marrow1.11163738
88MP0000026_abnormal_inner_ear1.09483146
89MP0002722_abnormal_immune_system1.07984321
90MP0000313_abnormal_cell_death1.07877665
91MP0003880_abnormal_central_pattern1.07637644
92MP0004742_abnormal_vestibular_system1.04769193
93MP0005257_abnormal_intraocular_pressure1.04662169
94MP0002282_abnormal_trachea_morphology1.04204470
95MP0000689_abnormal_spleen_morphology1.02621698
96MP0005391_vision/eye_phenotype1.02015927
97MP0001324_abnormal_eye_pigmentation1.01905886
98MP0009697_abnormal_copulation1.01452909
99MP0003119_abnormal_digestive_system1.01355173
100MP0001915_intracranial_hemorrhage1.01338924
101MP0008995_early_reproductive_senescence1.00725858
102MP0002233_abnormal_nose_morphology0.99252115
103MP0001929_abnormal_gametogenesis0.96989511
104MP0008438_abnormal_cutaneous_collagen0.96634218
105MP0003890_abnormal_embryonic-extraembry0.96069147
106MP0003787_abnormal_imprinting0.95898828
107MP0003937_abnormal_limbs/digits/tail_de0.95720928
108MP0001186_pigmentation_phenotype0.94078413
109MP0004885_abnormal_endolymph0.89869898
110MP0009053_abnormal_anal_canal0.89108241
111MP0005253_abnormal_eye_physiology0.88417398
112MP0000015_abnormal_ear_pigmentation0.87812538
113MP0004147_increased_porphyrin_level0.87367577
114MP0003878_abnormal_ear_physiology0.87224480
115MP0005377_hearing/vestibular/ear_phenot0.87224480
116MP0004233_abnormal_muscle_weight0.85822254
117MP0010678_abnormal_skin_adnexa0.85673538
118MP0002751_abnormal_autonomic_nervous0.85464097
119MP0003136_yellow_coat_color0.83987793
120MP0006035_abnormal_mitochondrial_morpho0.83052887
121MP0001800_abnormal_humoral_immune0.83038100
122MP0002638_abnormal_pupillary_reflex0.82880465
123MP0005551_abnormal_eye_electrophysiolog0.82745582
124MP0005195_abnormal_posterior_eye0.80007222
125MP0005397_hematopoietic_system_phenotyp0.78881779
126MP0001545_abnormal_hematopoietic_system0.78881779
127MP0002210_abnormal_sex_determination0.78487964
128MP0003755_abnormal_palate_morphology0.78480472
129MP0002429_abnormal_blood_cell0.78364223
130MP0005023_abnormal_wound_healing0.78230628
131MP0002160_abnormal_reproductive_system0.77352432
132MP0005623_abnormal_meninges_morphology0.76829630
133MP0003567_abnormal_fetal_cardiomyocyte0.76563856
134MP0002837_dystrophic_cardiac_calcinosis0.76351034
135MP0008770_decreased_survivor_rate0.76287000
136MP0001145_abnormal_male_reproductive0.76064880
137MP0009703_decreased_birth_body0.75641873
138MP0002249_abnormal_larynx_morphology0.75186257
139MP0003566_abnormal_cell_adhesion0.74205419
140MP0005423_abnormal_somatic_nervous0.73795439
141MP0003861_abnormal_nervous_system0.73789661
142MP0009745_abnormal_behavioral_response0.73519996
143MP0005646_abnormal_pituitary_gland0.73362425
144MP0009250_abnormal_appendicular_skeleto0.71245734
145MP0002928_abnormal_bile_duct0.70976604
146MP0002932_abnormal_joint_morphology0.70030103
147MP0005621_abnormal_cell_physiology0.69929778
148MP0003453_abnormal_keratinocyte_physiol0.68366514
149MP0001286_abnormal_eye_development0.67724354
150MP0001299_abnormal_eye_distance/0.67667798
151MP0003942_abnormal_urinary_system0.67012600
152MP0003806_abnormal_nucleotide_metabolis0.66736647
153MP0005384_cellular_phenotype0.66603157
154MP0002111_abnormal_tail_morphology0.66594262
155MP0002452_abnormal_antigen_presenting0.66495659
156MP0006036_abnormal_mitochondrial_physio0.65471589
157MP0002752_abnormal_somatic_nervous0.65269196
158MP0000716_abnormal_immune_system0.64655613
159MP0000653_abnormal_sex_gland0.64600243
160MP0003091_abnormal_cell_migration0.64553628
161MP0004145_abnormal_muscle_electrophysio0.64380012
162MP0005187_abnormal_penis_morphology0.63867719
163MP0002925_abnormal_cardiovascular_devel0.61053860
164MP0000685_abnormal_immune_system0.60848967

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.25672354
2Cutaneous melanoma (HP:0012056)4.95407995
3Mitochondrial inheritance (HP:0001427)4.61397582
4Abnormal mitochondria in muscle tissue (HP:0008316)4.60673274
5Acute encephalopathy (HP:0006846)4.47865408
6Increased hepatocellular lipid droplets (HP:0006565)4.46444191
7Progressive macrocephaly (HP:0004481)4.27874551
8Septo-optic dysplasia (HP:0100842)4.25455630
9Lipid accumulation in hepatocytes (HP:0006561)4.02266170
10Increased CSF lactate (HP:0002490)3.76185070
11Congenital, generalized hypertrichosis (HP:0004540)3.67864306
12Renal Fanconi syndrome (HP:0001994)3.62608250
13Hepatocellular necrosis (HP:0001404)3.54031380
14Reticulocytopenia (HP:0001896)3.53969868
15Subacute progressive viral hepatitis (HP:0006572)3.35148692
16Hypopigmentation of the fundus (HP:0007894)3.32874588
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.30137031
18Short 4th metacarpal (HP:0010044)3.30137031
19Poikilocytosis (HP:0004447)3.26474022
20Cerebral edema (HP:0002181)3.23192346
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.22589081
22Hepatic necrosis (HP:0002605)3.21774511
23Hypochromic microcytic anemia (HP:0004840)3.13836860
24Maternal diabetes (HP:0009800)3.09288433
25Impulsivity (HP:0100710)3.07965406
26Exertional dyspnea (HP:0002875)3.06246826
27Acanthocytosis (HP:0001927)3.00090672
283-Methylglutaconic aciduria (HP:0003535)2.99745516
29Abnormality of chromosome stability (HP:0003220)2.99075797
30Chromsome breakage (HP:0040012)2.98442987
31Abnormal number of incisors (HP:0011064)2.92337604
32Volvulus (HP:0002580)2.87153461
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.85487958
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.85487958
35Absent septum pellucidum (HP:0001331)2.84239325
36Abnormality of cells of the erythroid lineage (HP:0012130)2.83935106
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.78944361
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78604999
39Increased intramyocellular lipid droplets (HP:0012240)2.74042068
40Pancreatic cysts (HP:0001737)2.72910583
41Aplasia/Hypoplasia of the macula (HP:0008059)2.72581704
42Cortical dysplasia (HP:0002539)2.72434789
43Freckling (HP:0001480)2.69688598
44Absent frontal sinuses (HP:0002688)2.66814673
45Rhabdomyosarcoma (HP:0002859)2.65834149
46Abnormality of the ileum (HP:0001549)2.61821045
47Verrucae (HP:0200043)2.61806458
48Papilloma (HP:0012740)2.61806458
49True hermaphroditism (HP:0010459)2.61605744
50Selective tooth agenesis (HP:0001592)2.61098901
51Respiratory difficulties (HP:0002880)2.60644807
52Aplasia/Hypoplasia affecting the retina (HP:0008061)2.60485295
53Sandal gap (HP:0001852)2.59730920
54Colon cancer (HP:0003003)2.58018912
55Leukodystrophy (HP:0002415)2.54941292
56Thyroiditis (HP:0100646)2.54487965
57Astrocytoma (HP:0009592)2.52873275
58Abnormality of the astrocytes (HP:0100707)2.52873275
59Bilateral microphthalmos (HP:0007633)2.52829642
60Triphalangeal thumb (HP:0001199)2.52063824
61Spastic diplegia (HP:0001264)2.51410061
62Pancreatic fibrosis (HP:0100732)2.49525215
63Abnormality of reticulocytes (HP:0004312)2.47385661
64Optic disc pallor (HP:0000543)2.45793298
6511 pairs of ribs (HP:0000878)2.43141078
66Medulloblastoma (HP:0002885)2.42308178
67Abnormality of the septum pellucidum (HP:0007375)2.40117993
68Prominent nose (HP:0000448)2.36498974
69Abnormality of renal resorption (HP:0011038)2.36304933
70Anophthalmia (HP:0000528)2.36228212
71Ependymoma (HP:0002888)2.35381859
72Ulnar bowing (HP:0003031)2.35241050
73Heterotopia (HP:0002282)2.35203091
74Optic nerve hypoplasia (HP:0000609)2.34817928
75Esophageal atresia (HP:0002032)2.33975075
76Abnormality of the labia minora (HP:0012880)2.33926345
77Cafe-au-lait spot (HP:0000957)2.33186059
78Basal cell carcinoma (HP:0002671)2.31764456
79Respiratory failure (HP:0002878)2.31417984
80Abnormality of the phalanges of the 2nd finger (HP:0009541)2.30907658
81Entropion (HP:0000621)2.29885330
82High pitched voice (HP:0001620)2.29266538
83Pendular nystagmus (HP:0012043)2.23074510
84Abnormality of the 4th metacarpal (HP:0010012)2.22692831
85Abnormal number of erythroid precursors (HP:0012131)2.20994425
86Exercise intolerance (HP:0003546)2.20978340
87Increased muscle lipid content (HP:0009058)2.20749020
88Squamous cell carcinoma (HP:0002860)2.20374760
89Biliary tract neoplasm (HP:0100574)2.20138275
90Hematochezia (HP:0002573)2.18569468
91Birth length less than 3rd percentile (HP:0003561)2.17407747
92Abnormality of midbrain morphology (HP:0002418)2.17148002
93Molar tooth sign on MRI (HP:0002419)2.17148002
94Lactic acidosis (HP:0003128)2.16373385
95Partial duplication of the phalanx of hand (HP:0009999)2.14887135
96Glioma (HP:0009733)2.13882798
97Hypoplasia of the thymus (HP:0000778)2.13718222
98Cleft eyelid (HP:0000625)2.11750692
99Abnormality of the fingertips (HP:0001211)2.10883701
100Abnormality of the preputium (HP:0100587)2.10738181
101Partial duplication of thumb phalanx (HP:0009944)2.10639362
102Poikiloderma (HP:0001029)2.09229664
103Pallor (HP:0000980)2.08717636
104Conjunctival telangiectasia (HP:0000524)2.08308178
105Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06226231
106Gastrointestinal carcinoma (HP:0002672)2.05622578
107Malignant gastrointestinal tract tumors (HP:0006749)2.05622578
108Buphthalmos (HP:0000557)2.05477648
109Sclerocornea (HP:0000647)2.05330331
110Viral hepatitis (HP:0006562)2.03793398
111Agnosia (HP:0010524)2.02831139
112Thrombocytosis (HP:0001894)2.02766636
113Nephronophthisis (HP:0000090)2.02261397
114Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00259230
115Increased nuchal translucency (HP:0010880)2.00002996
116Increased serum lactate (HP:0002151)1.99997935
117Glycosuria (HP:0003076)1.99769931
118Abnormality of urine glucose concentration (HP:0011016)1.99769931
119Myelodysplasia (HP:0002863)1.99528016
120Sloping forehead (HP:0000340)1.98196143
121Hyperphosphaturia (HP:0003109)1.97605936
122Macrocytic anemia (HP:0001972)1.97471690
123T lymphocytopenia (HP:0005403)1.97468958
124Abnormality of the parietal bone (HP:0002696)1.96535093
125Concave nail (HP:0001598)1.96518839
126Rib fusion (HP:0000902)1.95499409
127Anencephaly (HP:0002323)1.94715774
128Cellulitis (HP:0100658)1.94427756
129Deviation of the thumb (HP:0009603)1.93934080
130Abnormality of the heme biosynthetic pathway (HP:0010472)1.93629976
131Neoplasm of striated muscle (HP:0009728)1.91917067
132Missing ribs (HP:0000921)1.89180432
133Small intestinal stenosis (HP:0012848)1.88961888
134Duodenal stenosis (HP:0100867)1.88961888
135Abnormality of the duodenum (HP:0002246)1.88447576
136Depressed nasal ridge (HP:0000457)1.88365575
137Abnormal lung lobation (HP:0002101)1.88285153
138Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88148153
139Neoplasm of the oral cavity (HP:0100649)1.87755295
140Reticulocytosis (HP:0001923)1.87432044
141Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87405660
142Holoprosencephaly (HP:0001360)1.87206861
143Cutis marmorata (HP:0000965)1.86524993
144Breast carcinoma (HP:0003002)1.86061676
145Abnormality of B cell number (HP:0010975)1.85995228
146B lymphocytopenia (HP:0010976)1.85995228
147Hypoplasia of the pons (HP:0012110)1.85366325
148Aplastic anemia (HP:0001915)1.84926962
149Truncal obesity (HP:0001956)1.82980711
150Bicuspid aortic valve (HP:0001647)1.81849390
151Proximal placement of thumb (HP:0009623)1.81424022
152Microvesicular hepatic steatosis (HP:0001414)1.81354656
153Aplasia/Hypoplasia of the patella (HP:0006498)1.79060052
154Intestinal polyposis (HP:0200008)1.78733427
155Ovarian neoplasm (HP:0100615)1.78620108
156Aplasia/Hypoplasia of the uvula (HP:0010293)1.78596878
157Myokymia (HP:0002411)1.77977050
158Short thumb (HP:0009778)1.77852673
159Increased density of long bones (HP:0006392)1.77730294
160Micronodular cirrhosis (HP:0001413)1.75640149
161Abnormality of the calcaneus (HP:0008364)1.75446156
162Atresia of the external auditory canal (HP:0000413)1.75207093
163Hemivertebrae (HP:0002937)1.75043637
164Mucosal telangiectasiae (HP:0100579)1.74954428
165Hypoplastic pelvis (HP:0008839)1.74827658
166Abnormality of T cell number (HP:0011839)1.74552764
167Oral leukoplakia (HP:0002745)1.74290703
168Intestinal polyp (HP:0005266)1.73604688
169Supernumerary bones of the axial skeleton (HP:0009144)1.73413035
170Supernumerary ribs (HP:0005815)1.72559529
171Low anterior hairline (HP:0000294)1.71088477
172Renovascular hypertension (HP:0100817)1.70886733
173Gastrointestinal atresia (HP:0002589)1.70669068
174Abnormality of oral frenula (HP:0000190)1.70615591
175Absent thumb (HP:0009777)1.70546911
176Cerebral aneurysm (HP:0004944)1.70540742
177Meckel diverticulum (HP:0002245)1.70095371
178Abnormality of the vasculature of the conjunctiva (HP:0008054)1.69928289
179Abnormality of the carotid arteries (HP:0005344)1.69505711
180Duplication of thumb phalanx (HP:0009942)1.68035242
181Generalized aminoaciduria (HP:0002909)1.66558263
182Aplasia/Hypoplasia of the tongue (HP:0010295)1.65785200
183Abnormality of the anterior horn cell (HP:0006802)1.65361510
184Degeneration of anterior horn cells (HP:0002398)1.65361510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.47159897
2ZAK6.17697209
3VRK26.04055057
4VRK13.45387716
5STK43.05843394
6CDC72.96121563
7RPS6KA52.67687283
8MAP3K102.57127645
9EEF2K2.51623036
10TAF12.50083983
11NME12.22452058
12SCYL22.14558614
13PLK42.12834946
14STK162.03330829
15DYRK22.01905938
16NEK21.98151395
17TNIK1.93085109
18PKN21.92186882
19CDK91.87923331
20INSRR1.77495719
21PBK1.72372266
22PIM11.61619336
23WNK31.61262114
24AURKB1.59168969
25WEE11.56051430
26MAP3K81.54111968
27MKNK11.42445044
28CHEK21.42247444
29SRPK11.41748079
30NUAK11.40366304
31PNCK1.39956939
32EPHB21.37794673
33RPS6KB21.33730947
34DAPK31.30331449
35FRK1.23627323
36BUB11.22418505
37UHMK11.21565472
38TTN1.16873649
39MKNK21.15003109
40PKN11.12496758
41GRK61.12342680
42ACVR1B1.09080768
43DYRK31.07068676
44PASK1.06168067
45ATR1.05901263
46DYRK1B1.05062533
47MST1R0.99257136
48TTK0.96098601
49MAPK150.95931440
50BMPR1B0.84788953
51FLT30.84350899
52TRIB30.84050592
53CDK120.83670525
54PLK10.82983548
55LRRK20.82619227
56STK100.81702223
57EIF2AK10.78325654
58MELK0.78219261
59CDK40.77667786
60CDK30.75089288
61AURKA0.73584239
62PRKCG0.71474506
63CSNK2A10.68017188
64ADRBK20.67875834
65NEK10.67074589
66GRK10.65878815
67CDK60.65626629
68STK30.65318943
69EPHA40.65133835
70ATM0.65062620
71TGFBR10.64723670
72CHEK10.64125559
73FGFR20.64032223
74TAOK30.60620898
75PLK30.59443254
76CAMK1D0.59383115
77MET0.58855917
78LATS10.58177730
79TESK10.58163951
80NME20.57206474
81CDK190.55594651
82EIF2AK30.55095272
83WNK40.54357285
84BRSK20.52617411
85EPHA20.51866375
86AKT20.51075008
87PRKAA10.49881467
88MAP4K20.48196988
89CDK20.47893586
90MUSK0.46469372
91MINK10.45934291
92MST40.45758032
93BMX0.44567495
94PTK60.44173733
95CSF1R0.40937390
96MAP3K40.40899492
97CSNK1E0.40290209
98CDK10.38691323
99ADRBK10.38357149
100CSNK1D0.37578349
101KSR10.35539280
102RPS6KA40.35284108
103MARK30.34316647
104JAK20.34166505
105NLK0.34025965
106IRAK20.32864548
107RPS6KB10.32778433
108DYRK1A0.32472521
109PAK20.31839367
110PDK20.30549433
111MTOR0.30488413
112OBSCN0.29722894
113FGR0.29656611
114MAPK130.29325782
115PRKDC0.28118209
116BCKDK0.27098952
117CDK70.27011131
118PRKCQ0.26981278
119PDGFRA0.26944122
120CDK80.26779975
121OXSR10.26522506
122ROCK10.26491441
123PAK40.26418065
124PRKACB0.26336297
125STK38L0.26335237
126PRKG10.25959267
127PDK40.25845268
128PDK30.25845268
129FGFR30.25674136
130MAP4K10.25187054
131CSNK1A10.25145403
132CLK10.24932634
133EIF2AK20.24838896
134PRKACA0.23191407
135ILK0.22083252
136CDK11A0.21230037
137TRPM70.20718894
138CDK150.20573741
139RIPK10.20395344
140PAK10.20295955
141FGFR10.20282403
142ERBB20.19218269
143BRSK10.18199094
144TSSK60.17478195
145CCNB10.17126314
146NTRK20.16132096
147AKT10.16106994
148PLK20.16034881
149ICK0.15975545
150RET0.15538181
151HIPK20.15515343
152MAPK140.14743773
153CSNK2A20.14617731
154GSK3A0.14194412
155CHUK0.12806506

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.60891082
2Oxidative phosphorylation_Homo sapiens_hsa001904.82567157
3Parkinsons disease_Homo sapiens_hsa050124.22476177
4* Viral carcinogenesis_Homo sapiens_hsa052033.40540066
5Proteasome_Homo sapiens_hsa030503.28618737
6Huntingtons disease_Homo sapiens_hsa050163.19710730
7Alzheimers disease_Homo sapiens_hsa050102.90309583
8DNA replication_Homo sapiens_hsa030302.61991424
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.61185568
10Cardiac muscle contraction_Homo sapiens_hsa042602.27588780
11Protein export_Homo sapiens_hsa030602.24669240
12Mismatch repair_Homo sapiens_hsa034302.10896893
13* Systemic lupus erythematosus_Homo sapiens_hsa0532211.6690304
14Transcriptional misregulation in cancer_Homo sapiens_hsa052021.92405688
15One carbon pool by folate_Homo sapiens_hsa006701.89579380
16Cell cycle_Homo sapiens_hsa041101.80416557
17Non-homologous end-joining_Homo sapiens_hsa034501.69300476
18Folate biosynthesis_Homo sapiens_hsa007901.59114666
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47482688
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41120857
21RNA transport_Homo sapiens_hsa030131.39500438
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39028888
23Fanconi anemia pathway_Homo sapiens_hsa034601.36014167
24Nucleotide excision repair_Homo sapiens_hsa034201.34466560
25Base excision repair_Homo sapiens_hsa034101.31507069
26Basal cell carcinoma_Homo sapiens_hsa052171.30918161
27Ribosome_Homo sapiens_hsa030101.25553539
28Homologous recombination_Homo sapiens_hsa034401.15522731
29Spliceosome_Homo sapiens_hsa030401.08551837
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08077859
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03709789
32Maturity onset diabetes of the young_Homo sapiens_hsa049500.97936214
33p53 signaling pathway_Homo sapiens_hsa041150.97570500
34Hedgehog signaling pathway_Homo sapiens_hsa043400.95066270
35Selenocompound metabolism_Homo sapiens_hsa004500.91652429
36MicroRNAs in cancer_Homo sapiens_hsa052060.90665729
37Small cell lung cancer_Homo sapiens_hsa052220.89318579
38mRNA surveillance pathway_Homo sapiens_hsa030150.89111947
39Pyruvate metabolism_Homo sapiens_hsa006200.88298909
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80998443
41Phototransduction_Homo sapiens_hsa047440.79678236
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75871293
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75642015
44Chronic myeloid leukemia_Homo sapiens_hsa052200.75091743
45Butanoate metabolism_Homo sapiens_hsa006500.74826247
46Glutathione metabolism_Homo sapiens_hsa004800.70998439
47Nicotine addiction_Homo sapiens_hsa050330.67222993
48Non-small cell lung cancer_Homo sapiens_hsa052230.66801830
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66455767
50Metabolic pathways_Homo sapiens_hsa011000.65273209
51HTLV-I infection_Homo sapiens_hsa051660.64295760
52Pyrimidine metabolism_Homo sapiens_hsa002400.61286265
53Vitamin digestion and absorption_Homo sapiens_hsa049770.61207574
54Linoleic acid metabolism_Homo sapiens_hsa005910.60092986
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.59808758
56mTOR signaling pathway_Homo sapiens_hsa041500.58185532
57RNA degradation_Homo sapiens_hsa030180.57991764
58Antigen processing and presentation_Homo sapiens_hsa046120.56214350
59Propanoate metabolism_Homo sapiens_hsa006400.55671859
60Oocyte meiosis_Homo sapiens_hsa041140.53637554
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53376610
62B cell receptor signaling pathway_Homo sapiens_hsa046620.52602735
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51464961
64Tryptophan metabolism_Homo sapiens_hsa003800.51150692
65Epstein-Barr virus infection_Homo sapiens_hsa051690.48588876
66Pancreatic cancer_Homo sapiens_hsa052120.48096370
67Apoptosis_Homo sapiens_hsa042100.47157386
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46988086
69Herpes simplex infection_Homo sapiens_hsa051680.46715551
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45021015
71Glioma_Homo sapiens_hsa052140.44961296
72Colorectal cancer_Homo sapiens_hsa052100.44413178
73Bladder cancer_Homo sapiens_hsa052190.44389717
74Steroid biosynthesis_Homo sapiens_hsa001000.43157856
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42977874
76Chemical carcinogenesis_Homo sapiens_hsa052040.42662792
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42343386
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42012716
79Hepatitis B_Homo sapiens_hsa051610.41951704
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41877705
81Biosynthesis of amino acids_Homo sapiens_hsa012300.40544351
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.39709161
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39665401
84Pentose phosphate pathway_Homo sapiens_hsa000300.39591834
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39447916
86Caffeine metabolism_Homo sapiens_hsa002320.38857510
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.38315093
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37961103
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37440330
90Renin-angiotensin system_Homo sapiens_hsa046140.36646681
91Tyrosine metabolism_Homo sapiens_hsa003500.34412739
92Lysine degradation_Homo sapiens_hsa003100.34169270
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33350963
94FoxO signaling pathway_Homo sapiens_hsa040680.33117346
95Prostate cancer_Homo sapiens_hsa052150.33002406
96Wnt signaling pathway_Homo sapiens_hsa043100.32552642
97Measles_Homo sapiens_hsa051620.32535802
98Legionellosis_Homo sapiens_hsa051340.32172680
99Proteoglycans in cancer_Homo sapiens_hsa052050.30715084
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29450164
101Retinol metabolism_Homo sapiens_hsa008300.29410008
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28382821
103HIF-1 signaling pathway_Homo sapiens_hsa040660.27993163
104beta-Alanine metabolism_Homo sapiens_hsa004100.27832683
105Endometrial cancer_Homo sapiens_hsa052130.27510025
106Olfactory transduction_Homo sapiens_hsa047400.26653937
107Melanoma_Homo sapiens_hsa052180.26440772
108Viral myocarditis_Homo sapiens_hsa054160.26168689
109Vitamin B6 metabolism_Homo sapiens_hsa007500.25865272
110Fatty acid elongation_Homo sapiens_hsa000620.25791342
111Inositol phosphate metabolism_Homo sapiens_hsa005620.25687100
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24682554
113Fat digestion and absorption_Homo sapiens_hsa049750.24149911
114RNA polymerase_Homo sapiens_hsa030200.23653578
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23420612
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23212991
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23179506
118Taste transduction_Homo sapiens_hsa047420.22920510
119Adherens junction_Homo sapiens_hsa045200.22597472
120Basal transcription factors_Homo sapiens_hsa030220.22462208
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22076170
122Thyroid cancer_Homo sapiens_hsa052160.21547676
123Primary immunodeficiency_Homo sapiens_hsa053400.20958229
124TGF-beta signaling pathway_Homo sapiens_hsa043500.20866035
125Focal adhesion_Homo sapiens_hsa045100.20785833
126Peroxisome_Homo sapiens_hsa041460.20742195
127Purine metabolism_Homo sapiens_hsa002300.20723994
128Phenylalanine metabolism_Homo sapiens_hsa003600.20501454
129AMPK signaling pathway_Homo sapiens_hsa041520.20043388
130Fatty acid degradation_Homo sapiens_hsa000710.19204643
131N-Glycan biosynthesis_Homo sapiens_hsa005100.19006397
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18728835
133Hematopoietic cell lineage_Homo sapiens_hsa046400.18385508
134Arachidonic acid metabolism_Homo sapiens_hsa005900.18315839
135Toxoplasmosis_Homo sapiens_hsa051450.17869768
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.17354759
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16827125
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.16266371
139Histidine metabolism_Homo sapiens_hsa003400.15002896
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.14535399
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.14502855
142Influenza A_Homo sapiens_hsa051640.14485985
143Insulin resistance_Homo sapiens_hsa049310.14196861
144Osteoclast differentiation_Homo sapiens_hsa043800.13906603
145Platelet activation_Homo sapiens_hsa046110.13838468
146Pathways in cancer_Homo sapiens_hsa052000.13774939
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13696398
148Fatty acid biosynthesis_Homo sapiens_hsa000610.13400339
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12783452
150Nitrogen metabolism_Homo sapiens_hsa009100.12774861
151Glucagon signaling pathway_Homo sapiens_hsa049220.12741996
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11560136
153Collecting duct acid secretion_Homo sapiens_hsa049660.11279910
154Serotonergic synapse_Homo sapiens_hsa047260.10719801
155Hippo signaling pathway_Homo sapiens_hsa043900.09694637
156Carbon metabolism_Homo sapiens_hsa012000.09606998
157Sulfur relay system_Homo sapiens_hsa041220.09174803
158Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.08456262
159AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.08422875
160Acute myeloid leukemia_Homo sapiens_hsa052210.08232976
161Ether lipid metabolism_Homo sapiens_hsa005650.08170965
162Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07595502
163Cocaine addiction_Homo sapiens_hsa050300.07425407
164GABAergic synapse_Homo sapiens_hsa047270.05930949

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