HIST1H3H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)9.47782538
2DNA replication-dependent nucleosome organization (GO:0034723)9.47782538
3chromatin assembly (GO:0031497)8.30926224
4regulation of histone H3-K9 methylation (GO:0051570)7.68449688
5nucleosome assembly (GO:0006334)7.38760408
6nucleosome organization (GO:0034728)6.35188352
7nuclear pore complex assembly (GO:0051292)6.24340770
8protein-DNA complex assembly (GO:0065004)6.22358563
9protein neddylation (GO:0045116)6.18265818
10nuclear pore organization (GO:0006999)6.11137940
11chromatin assembly or disassembly (GO:0006333)5.96068797
12DNA unwinding involved in DNA replication (GO:0006268)5.94550077
13antibacterial humoral response (GO:0019731)5.66983602
14protein-DNA complex subunit organization (GO:0071824)5.53645958
15mitotic chromosome condensation (GO:0007076)5.52034468
16innate immune response in mucosa (GO:0002227)5.46582712
17protein localization to kinetochore (GO:0034501)5.42887777
18thrombin receptor signaling pathway (GO:0070493)5.35039796
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.29515389
20antimicrobial humoral response (GO:0019730)5.26892208
21sister chromatid segregation (GO:0000819)5.19676789
22neutrophil activation involved in immune response (GO:0002283)4.98343188
23negative regulation of thymocyte apoptotic process (GO:0070244)4.97875212
24protein localization to chromosome, centromeric region (GO:0071459)4.74866796
25regulation of megakaryocyte differentiation (GO:0045652)4.72583243
26pore complex assembly (GO:0046931)4.69434521
27mitotic sister chromatid segregation (GO:0000070)4.55028089
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.50879735
29DNA replication initiation (GO:0006270)4.40898212
30negative regulation of histone methylation (GO:0031061)4.40740505
31platelet aggregation (GO:0070527)4.38676924
32chromatin remodeling at centromere (GO:0031055)4.31525924
33CENP-A containing nucleosome assembly (GO:0034080)4.28442816
34mucosal immune response (GO:0002385)4.16812965
35regulation of platelet aggregation (GO:0090330)4.16222234
36DNA duplex unwinding (GO:0032508)4.08121626
37DNA geometric change (GO:0032392)4.06883710
38folic acid-containing compound biosynthetic process (GO:0009396)4.02729724
39regulation of gene silencing (GO:0060968)4.01498654
40positive regulation of chromosome segregation (GO:0051984)4.01465628
41protein K6-linked ubiquitination (GO:0085020)3.98612183
42DNA strand elongation involved in DNA replication (GO:0006271)3.95479139
43positive regulation of endothelial cell differentiation (GO:0045603)3.94811245
44organ or tissue specific immune response (GO:0002251)3.93130633
45regulation of sister chromatid cohesion (GO:0007063)3.92909540
46DNA replication-independent nucleosome organization (GO:0034724)3.90112081
47DNA replication-independent nucleosome assembly (GO:0006336)3.90112081
48G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.89121068
49mitotic nuclear envelope disassembly (GO:0007077)3.89047980
50translesion synthesis (GO:0019985)3.88507673
51positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.88373810
52positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.88373810
53positive regulation of mitotic sister chromatid separation (GO:1901970)3.88373810
54blood coagulation, intrinsic pathway (GO:0007597)3.87262600
55chromosome condensation (GO:0030261)3.86668137
56mitotic sister chromatid cohesion (GO:0007064)3.85785751
57dosage compensation (GO:0007549)3.82781238
58negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.81307957
59regulation of centriole replication (GO:0046599)3.80282118
60regulation of gene silencing by miRNA (GO:0060964)3.78795123
61regulation of gene silencing by RNA (GO:0060966)3.78795123
62regulation of posttranscriptional gene silencing (GO:0060147)3.78795123
63adenosine receptor signaling pathway (GO:0001973)3.76842217
64defense response to Gram-positive bacterium (GO:0050830)3.76043866
65regulation of platelet activation (GO:0010543)3.74947143
66DNA strand elongation (GO:0022616)3.73104698
67kinetochore organization (GO:0051383)3.72973169
68polyamine biosynthetic process (GO:0006596)3.71247451
69nuclear envelope disassembly (GO:0051081)3.71075470
70membrane disassembly (GO:0030397)3.71075470
71negative regulation of homotypic cell-cell adhesion (GO:0034111)3.70187003
72positive regulation of histone methylation (GO:0031062)3.69591503
73negative regulation of norepinephrine secretion (GO:0010700)3.69313098
74megakaryocyte development (GO:0035855)3.68872270
75regulation of integrin activation (GO:0033623)3.68097964
76mitotic recombination (GO:0006312)3.66558101
77telomere maintenance via semi-conservative replication (GO:0032201)3.64603650
78DNA topological change (GO:0006265)3.63265813
79microtubule depolymerization (GO:0007019)3.63139136
80histone exchange (GO:0043486)3.60240656
81IMP biosynthetic process (GO:0006188)3.57703573
82leukocyte migration involved in inflammatory response (GO:0002523)3.54436224
83regulation of centrosome cycle (GO:0046605)3.53948400
84triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.53129584
85attachment of spindle microtubules to kinetochore (GO:0008608)3.51830985
86protoporphyrinogen IX metabolic process (GO:0046501)3.51570183
87regulation of Golgi to plasma membrane protein transport (GO:0042996)3.51420725
88pre-miRNA processing (GO:0031054)3.46380470
89postreplication repair (GO:0006301)3.45639041
90regulation of DNA endoreduplication (GO:0032875)3.43603695
91B cell mediated immunity (GO:0019724)3.43059060
92regulation of translational fidelity (GO:0006450)3.40869824
93regulation of chromosome segregation (GO:0051983)3.40633610
94DNA conformation change (GO:0071103)3.40464176
95DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.37000695
96meiotic chromosome segregation (GO:0045132)3.36904902
97mitochondrial calcium ion transport (GO:0006851)3.36547478
98lipoxygenase pathway (GO:0019372)3.34952271
99platelet formation (GO:0030220)3.33996967
100DNA packaging (GO:0006323)3.33088266
101telomere maintenance via recombination (GO:0000722)3.31314373
102regulation of RNA export from nucleus (GO:0046831)3.28226034
103regulation of centrosome duplication (GO:0010824)3.27566603
104deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25750933
105regulation of helicase activity (GO:0051095)3.24896507
106DNA synthesis involved in DNA repair (GO:0000731)3.23391288
107protein localization to chromosome (GO:0034502)3.20755505
108spindle checkpoint (GO:0031577)3.20466747
109regulation of mitotic metaphase/anaphase transition (GO:0030071)3.18758228
110B cell receptor signaling pathway (GO:0050853)3.18659947
111regulation of spindle organization (GO:0090224)3.18618698
112protoporphyrinogen IX biosynthetic process (GO:0006782)3.17704203
113ATP-dependent chromatin remodeling (GO:0043044)3.17548375
114positive regulation of macrophage differentiation (GO:0045651)3.16435114
115regulation of histone methylation (GO:0031060)3.16245240
116IMP metabolic process (GO:0046040)3.16029639
117negative regulation of DNA repair (GO:0045738)3.14389589
118chromosome segregation (GO:0007059)3.12999187
119histone lysine demethylation (GO:0070076)3.11067782
120spindle assembly checkpoint (GO:0071173)3.10868681
121nucleotide-excision repair, DNA gap filling (GO:0006297)3.10532131
122pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.10391194
123regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.09992325
124purinergic nucleotide receptor signaling pathway (GO:0035590)3.08773522
125mitotic metaphase plate congression (GO:0007080)3.06222116
126negative regulation of T cell apoptotic process (GO:0070233)3.05614131
127telomere maintenance (GO:0000723)3.04935844
128histone demethylation (GO:0016577)3.03152454
129immunoglobulin mediated immune response (GO:0016064)3.02626270
130regulation of mitotic sister chromatid separation (GO:0010965)3.01806224
131regulation of mitotic sister chromatid segregation (GO:0033047)3.01806224
132regulation of sister chromatid segregation (GO:0033045)3.01806224
133negative regulation of platelet activation (GO:0010544)3.01455116
134regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.00078332
135homotypic cell-cell adhesion (GO:0034109)2.99967807
136positive regulation of systemic arterial blood pressure (GO:0003084)2.99044175
137positive regulation of alpha-beta T cell proliferation (GO:0046641)2.94662737
138regulation of endothelial cell differentiation (GO:0045601)2.92915719
139negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.91555901
140pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.91301887
141regulation of thymocyte apoptotic process (GO:0070243)2.84669112
142positive regulation of cAMP-mediated signaling (GO:0043950)2.84650283
143platelet degranulation (GO:0002576)2.84491849
144positive regulation of mast cell activation (GO:0033005)2.79481316
145angiogenesis involved in wound healing (GO:0060055)2.72427041
146positive regulation of B cell mediated immunity (GO:0002714)2.67281150
147positive regulation of immunoglobulin mediated immune response (GO:0002891)2.67281150
148negative regulation of heart rate (GO:0010459)2.66767831
149positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.66600309
150platelet activation (GO:0030168)2.66576940
151pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.66479970
152regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.65929824
153G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.64603030
154low-density lipoprotein particle remodeling (GO:0034374)2.59827466
155antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.57687880
156negative regulation of lymphocyte apoptotic process (GO:0070229)2.56871854
157positive regulation of B cell differentiation (GO:0045579)2.56418958
158positive regulation of granulocyte differentiation (GO:0030854)2.56222266
159deoxyribonucleotide biosynthetic process (GO:0009263)2.54805338
160positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.49774431
161neutrophil activation (GO:0042119)2.48428159
162deoxyribose phosphate biosynthetic process (GO:0046385)2.46676876
1632-deoxyribonucleotide biosynthetic process (GO:0009265)2.46676876
164proline biosynthetic process (GO:0006561)2.46588407
165regulation of homotypic cell-cell adhesion (GO:0034110)2.46372538
166purinergic receptor signaling pathway (GO:0035587)2.45848384
167negative regulation of neural precursor cell proliferation (GO:2000178)2.45325575
168regulation of B cell receptor signaling pathway (GO:0050855)2.44730906
169regulation of macrophage derived foam cell differentiation (GO:0010743)2.42678889
170regulation of integrin-mediated signaling pathway (GO:2001044)2.38712682
171termination of G-protein coupled receptor signaling pathway (GO:0038032)2.38533324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.98275128
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.66687094
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.40181690
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.22883179
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.32203921
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.23009954
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44748118
8* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37265274
9* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.33475062
10* SOX2_16153702_ChIP-ChIP_HESCs_Human2.16372374
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.14009068
12SCL_19346495_ChIP-Seq_HPC-7_Human2.11380308
13* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.11195623
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.9300654
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95249119
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88729406
17IRF1_19129219_ChIP-ChIP_H3396_Human1.87857992
18* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.86107148
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.80374708
20* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79234341
21SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.76102074
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69844828
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69809983
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65057564
25SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.64743654
26SOX2_18555785_ChIP-Seq_MESCs_Mouse1.63796745
27* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58381419
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51881335
29AR_21909140_ChIP-Seq_LNCAP_Human1.51375189
30* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.46665333
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.45995692
32* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45662675
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42911594
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40071132
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37744600
36GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37180299
37* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35281612
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33906469
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.31719285
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30443229
41NANOG_16153702_ChIP-ChIP_HESCs_Human1.27707753
42* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26436179
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26435593
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25169512
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25079749
46* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23963538
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21595688
48* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21237207
49GATA2_19941826_ChIP-Seq_K562_Human1.21157643
50* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20464401
51* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19492647
52TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15889522
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15175807
54* MAF_26560356_Chip-Seq_TH1_Human1.14368889
55* VDR_23849224_ChIP-Seq_CD4+_Human1.13346388
56* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.12966970
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.12176079
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.09182808
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08141153
60ELK1_19687146_ChIP-ChIP_HELA_Human1.06169924
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04955861
62MYC_22102868_ChIP-Seq_BL_Human1.02927714
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02204884
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00774918
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.00176187
66UTX_26944678_Chip-Seq_JUKART_Human0.97741544
67MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97487145
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97197538
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97086463
70STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95907437
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94741299
72MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93799966
73MYB_26560356_Chip-Seq_TH1_Human0.93251966
74E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90828308
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89790405
76ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89144878
77PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87382578
78SPI1_23127762_ChIP-Seq_K562_Human0.87255558
79MYB_26560356_Chip-Seq_TH2_Human0.87102226
80THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86926371
81* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86509987
82* NCOR1_26117541_ChIP-Seq_K562_Human0.85565291
83GATA1_22025678_ChIP-Seq_K562_Human0.85301763
84XRN2_22483619_ChIP-Seq_HELA_Human0.84149363
85SPI1_20517297_ChIP-Seq_HL60_Human0.83600121
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.83233191
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82898703
88FOXP3_21729870_ChIP-Seq_TREG_Human0.82892064
89MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82749649
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82070946
91* SALL4_22934838_ChIP-ChIP_CD34+_Human0.81812648
92SPI1_23547873_ChIP-Seq_NB4_Human0.81404385
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81012701
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80485343
95ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78520346
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.77637331
97STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77446037
98* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76490737
99* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76216845
100* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75211980
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74642164
102VDR_24763502_ChIP-Seq_THP-1_Human0.73992684
103NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.73891272
104NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.72378947
105RBPJ_22232070_ChIP-Seq_NCS_Mouse0.72361753
106NANOG_21062744_ChIP-ChIP_HESCs_Human0.72138788
107FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.71850046
108VDR_21846776_ChIP-Seq_THP-1_Human0.71795188
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.71775964
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71037682
111SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.70685372
112RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.70312134
113GATA3_27048872_Chip-Seq_THYMUS_Human0.69898108
114IRF8_22096565_ChIP-ChIP_GC-B_Human0.69881185
115CREB1_15753290_ChIP-ChIP_HEK293T_Human0.69561727
116SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.68248738
117* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.67403430
118* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.66732581
119POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.66663899
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.65284833
121TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.64459892
122KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.63172917
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.62411598
124CIITA_25753668_ChIP-Seq_RAJI_Human0.60847213
125KDM5A_27292631_Chip-Seq_BREAST_Human0.60660046
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.60580895
127GATA1_19941826_ChIP-Seq_K562_Human0.60564448
128* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.58098460
129POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.57692223
130MYC_18940864_ChIP-ChIP_HL60_Human0.57616033
131EST1_17652178_ChIP-ChIP_JURKAT_Human0.56192651
132SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.55033042
133GATA2_22383799_ChIP-Seq_G1ME_Mouse0.54942143
134* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.53921604
135ZNF263_19887448_ChIP-Seq_K562_Human0.53423499
136ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.53212191
137TTF2_22483619_ChIP-Seq_HELA_Human0.52363364
138CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.52003221
139SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.51669264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology7.56826866
2MP0010094_abnormal_chromosome_stability4.90172362
3MP0003111_abnormal_nucleus_morphology4.34554690
4MP0010307_abnormal_tumor_latency3.91709815
5MP0003077_abnormal_cell_cycle3.69563201
6MP0008004_abnormal_stomach_pH3.59905547
7MP0003693_abnormal_embryo_hatching3.35535840
8MP0008057_abnormal_DNA_replication3.15778098
9MP0010352_gastrointestinal_tract_polyps3.10258973
10MP0001835_abnormal_antigen_presentation3.07751940
11MP0004957_abnormal_blastocyst_morpholog3.03162283
12MP0003705_abnormal_hypodermis_morpholog2.90612336
13MP0000465_gastrointestinal_hemorrhage2.68291263
14MP0003656_abnormal_erythrocyte_physiolo2.66154343
15MP0004147_increased_porphyrin_level2.65002157
16MP0005671_abnormal_response_to2.57305511
17MP0003123_paternal_imprinting2.57214261
18MP0003121_genomic_imprinting2.51319365
19MP0000685_abnormal_immune_system2.46884594
20MP0008058_abnormal_DNA_repair2.41064157
21MP0005076_abnormal_cell_differentiation2.36253237
22MP0000350_abnormal_cell_proliferation2.30927574
23MP0005645_abnormal_hypothalamus_physiol2.27399981
24MP0001730_embryonic_growth_arrest2.26768305
25MP0008007_abnormal_cellular_replicative2.17790535
26MP0008932_abnormal_embryonic_tissue2.15503470
27MP0010234_abnormal_vibrissa_follicle2.14500795
28MP0003303_peritoneal_inflammation2.09703986
29MP0009697_abnormal_copulation2.08628229
30MP0008877_abnormal_DNA_methylation2.05060651
31MP0003763_abnormal_thymus_physiology2.03634282
32MP0001800_abnormal_humoral_immune2.01276560
33MP0003724_increased_susceptibility_to1.97535040
34MP0005000_abnormal_immune_tolerance1.96113860
35MP0004197_abnormal_fetal_growth/weight/1.95250773
36MP0000537_abnormal_urethra_morphology1.94785892
37MP0002084_abnormal_developmental_patter1.87953164
38MP0002086_abnormal_extraembryonic_tissu1.83960811
39MP0001697_abnormal_embryo_size1.82353676
40MP0001672_abnormal_embryogenesis/_devel1.76861985
41MP0005380_embryogenesis_phenotype1.76861985
42MP0004808_abnormal_hematopoietic_stem1.74679362
43MP0002085_abnormal_embryonic_tissue1.74394515
44MP0006054_spinal_hemorrhage1.69777582
45MP0002396_abnormal_hematopoietic_system1.67171287
46MP0010155_abnormal_intestine_physiology1.67151837
47MP0002429_abnormal_blood_cell1.62057895
48MP0002080_prenatal_lethality1.59950736
49MP0002723_abnormal_immune_serum1.56806183
50MP0002452_abnormal_antigen_presenting1.56543096
51MP0001661_extended_life_span1.56017978
52MP0003984_embryonic_growth_retardation1.53657693
53MP0003937_abnormal_limbs/digits/tail_de1.52182399
54MP0000490_abnormal_crypts_of1.51822452
55MP0002088_abnormal_embryonic_growth/wei1.51612617
56MP0000343_altered_response_to1.51348384
57MP0003787_abnormal_imprinting1.50842099
58MP0005387_immune_system_phenotype1.48004014
59MP0001790_abnormal_immune_system1.48004014
60MP0002420_abnormal_adaptive_immunity1.44983894
61MP0000716_abnormal_immune_system1.43874618
62MP0004510_myositis1.43727182
63MP0004084_abnormal_cardiac_muscle1.42034486
64MP0001819_abnormal_immune_cell1.40656440
65MP0003786_premature_aging1.40091458
66MP0004947_skin_inflammation1.40042982
67MP0002009_preneoplasia1.37451791
68MP0001293_anophthalmia1.31804555
69MP0005084_abnormal_gallbladder_morpholo1.30693953
70MP0002019_abnormal_tumor_incidence1.29896479
71MP0000313_abnormal_cell_death1.26076613
72MP0000358_abnormal_cell_content/1.25441559
73MP0002148_abnormal_hypersensitivity_rea1.24693850
74MP0006035_abnormal_mitochondrial_morpho1.24548501
75MP0010030_abnormal_orbit_morphology1.22918136
76MP0001879_abnormal_lymphatic_vessel1.22151440
77MP0002111_abnormal_tail_morphology1.21659584
78MP0003890_abnormal_embryonic-extraembry1.20793788
79MP0009053_abnormal_anal_canal1.19665923
80MP0002092_abnormal_eye_morphology1.19076026
81MP0004264_abnormal_extraembryonic_tissu1.18877001
82MP0000733_abnormal_muscle_development1.18756972
83MP0002697_abnormal_eye_size1.18591028
84MP0005410_abnormal_fertilization1.17663547
85MP0009703_decreased_birth_body1.13888534
86MP0009333_abnormal_splenocyte_physiolog1.13887816
87MP0005083_abnormal_biliary_tract1.13167909
88MP0002132_abnormal_respiratory_system1.13060481
89MP0000703_abnormal_thymus_morphology1.11247002
90MP0003283_abnormal_digestive_organ1.09978848
91MP0009672_abnormal_birth_weight1.08727946
92MP0008770_decreased_survivor_rate1.04611472
93MP0003119_abnormal_digestive_system1.04598560
94MP0001915_intracranial_hemorrhage1.04326031
95MP0000858_altered_metastatic_potential1.03010175
96MP0000015_abnormal_ear_pigmentation1.01780202
97MP0001845_abnormal_inflammatory_respons1.01586684
98MP0000428_abnormal_craniofacial_morphol1.01164062
99MP0008872_abnormal_physiological_respon1.00491868
100MP0009763_increased_sensitivity_to0.99790821
101MP0005025_abnormal_response_to0.98558224
102MP0003567_abnormal_fetal_cardiomyocyte0.97951704
103MP0004036_abnormal_muscle_relaxation0.97818005
104MP0005167_abnormal_blood-brain_barrier0.97685685
105MP0003436_decreased_susceptibility_to0.97222710
106MP0001851_eye_inflammation0.95629783
107MP0005623_abnormal_meninges_morphology0.94697423
108MP0005058_abnormal_lysosome_morphology0.93980528
109MP0003861_abnormal_nervous_system0.91937620
110MP0008260_abnormal_autophagy0.91663115
111MP0003115_abnormal_respiratory_system0.90670527
112MP0009764_decreased_sensitivity_to0.90233917
113MP0002722_abnormal_immune_system0.88829627
114MP0010678_abnormal_skin_adnexa0.87472645
115MP0002925_abnormal_cardiovascular_devel0.87130915
116MP0000230_abnormal_systemic_arterial0.86615605
117MP0000249_abnormal_blood_vessel0.86087948
118MP0005187_abnormal_penis_morphology0.83834949
119MP0002736_abnormal_nociception_after0.83597054
120MP0003828_pulmonary_edema0.83498778
121MP0002398_abnormal_bone_marrow0.82975367
122MP0002877_abnormal_melanocyte_morpholog0.81753444
123MP0001663_abnormal_digestive_system0.81707493
124MP0004185_abnormal_adipocyte_glucose0.81446936
125MP0008775_abnormal_heart_ventricle0.79399870
126MP0001145_abnormal_male_reproductive0.78697027
127MP0005621_abnormal_cell_physiology0.78088783
128MP0005647_abnormal_sex_gland0.77983356
129MP0002166_altered_tumor_susceptibility0.77982300
130MP0005384_cellular_phenotype0.77861146
131MP0000689_abnormal_spleen_morphology0.77851541
132MP0004130_abnormal_muscle_cell0.77780813
133MP0001286_abnormal_eye_development0.77587965
134MP0002210_abnormal_sex_determination0.77249947
135MP0003183_abnormal_peptide_metabolism0.76576263
136MP0001849_ear_inflammation0.76415035
137MP0003566_abnormal_cell_adhesion0.76371054
138MP0003453_abnormal_keratinocyte_physiol0.75011344
139MP0001929_abnormal_gametogenesis0.74354019
140MP0005310_abnormal_salivary_gland0.73426087
141MP0009765_abnormal_xenobiotic_induced0.73137286
142MP0000432_abnormal_head_morphology0.72936031
143MP0005023_abnormal_wound_healing0.72884625
144MP0002419_abnormal_innate_immunity0.72574122
145MP0004233_abnormal_muscle_weight0.72300951
146MP0002006_tumorigenesis0.71662329
147MP0003935_abnormal_craniofacial_develop0.68506756
148MP0008438_abnormal_cutaneous_collagen0.68174244
149MP0003300_gastrointestinal_ulcer0.67391789
150MP0009278_abnormal_bone_marrow0.66963865
151MP0006072_abnormal_retinal_apoptosis0.66614164
152MP0000266_abnormal_heart_morphology0.65133315
153MP0000653_abnormal_sex_gland0.64617056
154MP0005501_abnormal_skin_physiology0.64417841
155MP0003718_maternal_effect0.64095377
156MP0003941_abnormal_skin_development0.63489629
157MP0004272_abnormal_basement_membrane0.63482153
158MP0002282_abnormal_trachea_morphology0.62449749
159MP0000462_abnormal_digestive_system0.62419240
160MP0000477_abnormal_intestine_morphology0.61199266
161MP0001545_abnormal_hematopoietic_system0.60531002
162MP0005397_hematopoietic_system_phenotyp0.60531002

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)8.63719161
2Increased mean platelet volume (HP:0011877)8.48070465
3Abnormal platelet volume (HP:0011876)8.16244503
4Petechiae (HP:0000967)8.13909837
5Menorrhagia (HP:0000132)7.71838150
6Purpura (HP:0000979)6.88391849
7Epistaxis (HP:0000421)5.89248464
8Poikilocytosis (HP:0004447)5.10097309
9Abnormal platelet function (HP:0011869)4.76675974
10Impaired platelet aggregation (HP:0003540)4.76675974
11Gingival bleeding (HP:0000225)4.63290776
12IgA deficiency (HP:0002720)4.42233598
13Spontaneous hematomas (HP:0007420)3.93358562
14IgM deficiency (HP:0002850)3.85739025
15Dyschromatopsia (HP:0007641)3.81048402
16Hyperlipoproteinemia (HP:0010980)3.77774351
17Acanthocytosis (HP:0001927)3.71284876
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.52724131
19Gastrointestinal stroma tumor (HP:0100723)3.49939680
20Chromsome breakage (HP:0040012)3.47315494
21Hypochromic microcytic anemia (HP:0004840)3.42534400
22Paralysis (HP:0003470)3.38342000
23Medulloblastoma (HP:0002885)3.32364791
24Reticulocytosis (HP:0001923)3.25510423
25Impulsivity (HP:0100710)3.25056026
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.24434758
27Short 4th metacarpal (HP:0010044)3.24434758
28Ependymoma (HP:0002888)3.17282479
29Abnormality of reticulocytes (HP:0004312)3.15349777
30Abnormality of the heme biosynthetic pathway (HP:0010472)3.13129874
31Colon cancer (HP:0003003)3.12625240
32Abnormality of chromosome stability (HP:0003220)3.11754652
33Conjunctival telangiectasia (HP:0000524)3.09888107
34Abnormality of the astrocytes (HP:0100707)3.08712730
35Astrocytoma (HP:0009592)3.08712730
36Volvulus (HP:0002580)2.99422316
37Reticulocytopenia (HP:0001896)2.97286405
38Colitis (HP:0002583)2.90079737
39Cutaneous melanoma (HP:0012056)2.84382185
40Selective tooth agenesis (HP:0001592)2.72047649
41Glioma (HP:0009733)2.71698657
42Increased density of long bones (HP:0006392)2.67831216
43Recurrent sinusitis (HP:0011108)2.64784590
44Autoimmune hemolytic anemia (HP:0001890)2.64355683
45Abnormality of the vasculature of the conjunctiva (HP:0008054)2.63675884
46Abnormality of the labia minora (HP:0012880)2.61273372
47Rhabdomyosarcoma (HP:0002859)2.60740168
48Increased IgM level (HP:0003496)2.59312239
49Inflammation of the large intestine (HP:0002037)2.56560908
50Neoplasm of the oral cavity (HP:0100649)2.56344547
51Agnosia (HP:0010524)2.55645052
52Abnormality of the prostate (HP:0008775)2.53907041
53Cafe-au-lait spot (HP:0000957)2.51107322
54Basal cell carcinoma (HP:0002671)2.50212598
55Agammaglobulinemia (HP:0004432)2.49895732
56Increased nuchal translucency (HP:0010880)2.49546794
57Abnormality of lateral ventricle (HP:0030047)2.45899841
58Cellulitis (HP:0100658)2.45634359
59Abnormality of the common coagulation pathway (HP:0010990)2.45439141
60Uterine leiomyosarcoma (HP:0002891)2.44879877
61Leiomyosarcoma (HP:0100243)2.44879877
62Birth length less than 3rd percentile (HP:0003561)2.42806177
63High pitched voice (HP:0001620)2.41610611
64Insomnia (HP:0100785)2.40593775
65Sandal gap (HP:0001852)2.40018878
66Gastrointestinal inflammation (HP:0004386)2.36870124
67Lymphopenia (HP:0001888)2.35052059
68Ulnar bowing (HP:0003031)2.33630917
69Tinnitus (HP:0000360)2.32140361
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.31979132
71Hepatosplenomegaly (HP:0001433)2.31312528
72Small intestinal stenosis (HP:0012848)2.29782767
73Duodenal stenosis (HP:0100867)2.29782767
74Abnormality of cells of the lymphoid lineage (HP:0012140)2.26884156
75Deviation of the thumb (HP:0009603)2.26580232
76Meckel diverticulum (HP:0002245)2.26507473
77Dysautonomia (HP:0002459)2.25792155
78Cortical dysplasia (HP:0002539)2.25277823
79Bruising susceptibility (HP:0000978)2.25180725
80Abnormality of the 4th metacarpal (HP:0010012)2.24768045
81Upper limb muscle weakness (HP:0003484)2.22413906
82Gastrointestinal carcinoma (HP:0002672)2.21390149
83Malignant gastrointestinal tract tumors (HP:0006749)2.21390149
84Lymphoma (HP:0002665)2.21060569
85Panhypogammaglobulinemia (HP:0003139)2.20856448
86Abnormality of cells of the erythroid lineage (HP:0012130)2.20644441
87Heterotopia (HP:0002282)2.20427799
88Abnormality of macrophages (HP:0004311)2.20284896
89Abnormal pupillary function (HP:0007686)2.20238310
90Proximal placement of thumb (HP:0009623)2.18062652
91Prominent nose (HP:0000448)2.18057843
92Renovascular hypertension (HP:0100817)2.18021277
93Chronic obstructive pulmonary disease (HP:0006510)2.16192609
94Obstructive lung disease (HP:0006536)2.16192609
95Erythema (HP:0010783)2.16175956
96Abnormality of the ileum (HP:0001549)2.16040327
97Eczematoid dermatitis (HP:0000976)2.14332721
98IgG deficiency (HP:0004315)2.13908018
99Cholecystitis (HP:0001082)2.11702390
100Abnormal gallbladder physiology (HP:0012438)2.11702390
101Biliary tract neoplasm (HP:0100574)2.11576687
102Absent frontal sinuses (HP:0002688)2.10752520
103Neoplasm of striated muscle (HP:0009728)2.08894531
104Sloping forehead (HP:0000340)2.07627602
105Hypopigmentation of the fundus (HP:0007894)2.07612790
106Abnormality of the carotid arteries (HP:0005344)2.07411973
107Recurrent viral infections (HP:0004429)2.06600531
108Meningitis (HP:0001287)2.06236668
109Transitional cell carcinoma of the bladder (HP:0006740)2.04022193
110Spastic diplegia (HP:0001264)2.03192151
111Abnormal auditory evoked potentials (HP:0006958)2.01599348
112Myelodysplasia (HP:0002863)2.01397179
113Ectopic kidney (HP:0000086)2.01164677
114Subacute progressive viral hepatitis (HP:0006572)2.00334640
115Bladder neoplasm (HP:0009725)1.98802288
116Bladder carcinoma (HP:0002862)1.98802288
117Macrocytic anemia (HP:0001972)1.97990018
118Abnormality of the fingertips (HP:0001211)1.97670501
11911 pairs of ribs (HP:0000878)1.96662809
1203-Methylglutaconic aciduria (HP:0003535)1.94438686
121Abnormality of iron homeostasis (HP:0011031)1.94181534
122Aplasia/Hypoplasia of the sternum (HP:0006714)1.93896809
123Abnormality of the preputium (HP:0100587)1.93305106
124Abnormality of the duodenum (HP:0002246)1.92736583
125Squamous cell carcinoma (HP:0002860)1.92181521
126Missing ribs (HP:0000921)1.91309160
127Abnormality of T cell physiology (HP:0011840)1.90806269
128Patellar aplasia (HP:0006443)1.90011741
129Abnormality of chromosome segregation (HP:0002916)1.90002410
130Encephalitis (HP:0002383)1.89601161
131Papillary thyroid carcinoma (HP:0002895)1.89246239
132Abnormal lung lobation (HP:0002101)1.89048884
133Freckling (HP:0001480)1.88896835
134Orthostatic hypotension (HP:0001278)1.88833025
135Emphysema (HP:0002097)1.87341734
136Abnormal number of erythroid precursors (HP:0012131)1.87110976
137Osteomalacia (HP:0002749)1.86872572
138High anterior hairline (HP:0009890)1.86488708
139Atresia of the external auditory canal (HP:0000413)1.85693358
140Intestinal polyposis (HP:0200008)1.83732924
141Hyperacusis (HP:0010780)1.82880984
142Absent radius (HP:0003974)1.82827766
143Vasculitis (HP:0002633)1.82764317
144Nephroblastoma (Wilms tumor) (HP:0002667)1.82597572
145Recurrent bronchitis (HP:0002837)1.82440269
146Renal duplication (HP:0000075)1.81994653
147Joint swelling (HP:0001386)1.81368866
148Ovarian neoplasm (HP:0100615)1.81169993
149Intestinal polyp (HP:0005266)1.80986527
150Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.79709818
151Absent thumb (HP:0009777)1.79357527
152Increased serum ferritin (HP:0003281)1.77834680
153B lymphocytopenia (HP:0010976)1.76797871
154Abnormality of transition element cation homeostasis (HP:0011030)1.76523332
155Acute hepatic failure (HP:0006554)1.76178610
156Abnormality of B cell number (HP:0010975)1.75679303
157Ridged nail (HP:0001807)1.75174717
158Truncal obesity (HP:0001956)1.75134866
159Skull defect (HP:0001362)1.74989879
160Osteomyelitis (HP:0002754)1.74538414
161Pancreatic islet-cell hyperplasia (HP:0004510)1.74502683
162Abnormal number of incisors (HP:0011064)1.73967389
163Neoplasm of the pancreas (HP:0002894)1.73625545
164Chronic diarrhea (HP:0002028)1.73285394
165Fibrous tissue neoplasm (HP:0012316)1.73010311
166Abnormality of the calcaneus (HP:0008364)1.72355043
167Nausea (HP:0002018)1.72198432
168Dry hair (HP:0011359)1.72085892
169Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.71801213
170Microtia (HP:0008551)1.71581153
171Septate vagina (HP:0001153)1.71324234
172Aplasia/Hypoplasia of the patella (HP:0006498)1.70757826
173Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68778182
174Abnormality of alanine metabolism (HP:0010916)1.68778182
175Hyperalaninemia (HP:0003348)1.68778182
176Short thumb (HP:0009778)1.68056637
177Embryonal renal neoplasm (HP:0011794)1.67939429
178Hypochromic anemia (HP:0001931)1.67837865
179Mucosal telangiectasiae (HP:0100579)1.67782936
180Amaurosis fugax (HP:0100576)1.67631231
181Bowel diverticulosis (HP:0005222)1.67598195
182Absent forearm bone (HP:0003953)1.67041422
183Aplasia involving forearm bones (HP:0009822)1.67041422
184Urticaria (HP:0001025)1.66796931
185Recurrent bacterial skin infections (HP:0005406)1.61420193
186Leukopenia (HP:0001882)1.61078946
187Breast hypoplasia (HP:0003187)1.61022565

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.47375732
2ZAK6.11001082
3CDC73.44578936
4VRK13.34249388
5STK43.15473041
6RPS6KA52.96063532
7MST42.66950919
8MAP3K102.62645674
9RIPK42.41418705
10CDK92.17308269
11EEF2K2.10732768
12NEK22.04649956
13SCYL22.00664896
14BTK1.88766767
15BMX1.78202175
16CDK121.74262321
17BUB11.70413445
18PKN21.69566464
19SRPK11.69287162
20CHEK21.68253344
21AURKB1.65586454
22MAP3K81.60212838
23WEE11.55764576
24PIM11.54776740
25SYK1.41289683
26TEC1.41060303
27RPS6KB21.39730118
28TTK1.34394498
29SMG11.27880660
30EPHA21.26613273
31BLK1.25612470
32DYRK31.14701666
33PASK1.11743512
34ATR1.09276490
35PIM21.08952688
36PKN11.06099074
37PLK11.05812308
38CDK41.05148928
39DAPK30.99260361
40TTN0.98349322
41AURKA0.97964017
42PIK3CG0.97914552
43CSF1R0.97707223
44GRK60.95614612
45NEK10.91761053
46ILK0.84045060
47EIF2AK10.83837145
48BMPR20.83371938
49CCNB10.82197706
50FLT30.80739200
51MELK0.80250309
52CHEK10.80241897
53STK240.79981037
54MYLK0.79705524
55STK100.75135865
56ATM0.75077376
57PLK30.72787379
58LYN0.72428747
59CDK60.71833844
60ACVR1B0.71514858
61CAMK1D0.71214526
62PTK2B0.66463183
63CDK20.66443081
64IKBKB0.65908401
65AKT20.63763053
66TAF10.62820198
67HCK0.62200802
68GRK50.61436294
69CDK70.61385980
70BRD40.60871537
71MAPK110.59998109
72FGFR20.59151775
73IRAK40.58827990
74MAP2K30.58193726
75LATS10.58047733
76ARAF0.57534672
77BRAF0.56014491
78MAPKAPK30.54965859
79STK30.54615681
80KSR10.54213245
81CDK10.53336658
82DYRK1B0.52426336
83NME20.51286634
84CSNK1D0.50722574
85ICK0.50210812
86LRRK20.48332462
87BRSK20.47817886
88TRIB30.47072882
89PRKAA10.45879842
90MTOR0.45642577
91NEK90.45217095
92PBK0.43429468
93TESK20.43122594
94FRK0.42838180
95TGFBR10.42108331
96CLK10.38547097
97PTK60.38510996
98ZAP700.38475490
99BRSK10.37689970
100CDK80.36206363
101STK160.35959654
102IRAK30.35946259
103RAF10.34885518
104PRKDC0.34767672
105RET0.33973839
106MARK30.33347730
107PAK40.32571014
108PDGFRA0.32310000
109LMTK20.31538485
110PLK40.31446949
111TNK20.30139371
112MAP4K10.29550051
113EIF2AK30.28852958
114PAK20.28187441
115ROCK10.26694452
116MAPK140.25757937
117MKNK10.25516804
118PAK10.25487714
119PRKCD0.24937470
120ALK0.24526531
121BCKDK0.23744754
122FGR0.23352989
123AKT10.21940014
124EIF2AK20.20037173
125JAK20.19725351
126PDK10.19702220
127MAPK120.18526158
128KDR0.18383839
129TAOK30.18256719
130FGFR10.18148153
131MET0.16385431
132CSNK2A20.16285168
133MAPKAPK50.16140707
134RPS6KB10.15276702
135EPHA30.15105009
136NUAK10.14379340
137PRKACG0.13910366
138DAPK10.13901012
139FES0.13821954
140TSSK60.13808426
141MAP2K70.13793409
142PRKCI0.13566660
143NLK0.13201415
144RPS6KA30.13049593
145PRKCQ0.13028209
146CSNK1G30.12672421
147TRPM70.12564973
148MAP2K10.12373215
149GSK3B0.11950937
150ITK0.11913130
151RIPK10.11771810
152RPS6KA40.11752178
153CSNK1A1L0.10431640
154MAPK10.10388298
155MKNK20.09870189
156MAPK90.09488511
157MAPK80.09397303

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.70446042
2Viral carcinogenesis_Homo sapiens_hsa052033.43919557
3DNA replication_Homo sapiens_hsa030302.91400663
4Mismatch repair_Homo sapiens_hsa034302.43799959
5Cell cycle_Homo sapiens_hsa041102.00133439
6* Systemic lupus erythematosus_Homo sapiens_hsa0532211.6455333
7One carbon pool by folate_Homo sapiens_hsa006701.90069162
8* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.72017267
9Primary immunodeficiency_Homo sapiens_hsa053401.65110516
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59581988
11Nucleotide excision repair_Homo sapiens_hsa034201.53063112
12Non-homologous end-joining_Homo sapiens_hsa034501.51279725
13Fanconi anemia pathway_Homo sapiens_hsa034601.50920497
14RNA transport_Homo sapiens_hsa030131.49897773
15Base excision repair_Homo sapiens_hsa034101.48562618
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.46335785
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40757413
18Homologous recombination_Homo sapiens_hsa034401.36771429
19Spliceosome_Homo sapiens_hsa030401.32601069
20Allograft rejection_Homo sapiens_hsa053301.27639014
21Asthma_Homo sapiens_hsa053101.26120696
22Autoimmune thyroid disease_Homo sapiens_hsa053201.18585900
23Graft-versus-host disease_Homo sapiens_hsa053321.13530074
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08620150
25mRNA surveillance pathway_Homo sapiens_hsa030151.05030409
26MicroRNAs in cancer_Homo sapiens_hsa052060.98745789
27Ribosome_Homo sapiens_hsa030100.98365662
28p53 signaling pathway_Homo sapiens_hsa041150.90271234
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86906908
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78822082
31Small cell lung cancer_Homo sapiens_hsa052220.77139065
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76379392
33Chronic myeloid leukemia_Homo sapiens_hsa052200.73418510
34Selenocompound metabolism_Homo sapiens_hsa004500.72266701
35Type I diabetes mellitus_Homo sapiens_hsa049400.70469108
36Oocyte meiosis_Homo sapiens_hsa041140.66443783
37Non-small cell lung cancer_Homo sapiens_hsa052230.65977236
38Pyrimidine metabolism_Homo sapiens_hsa002400.65761266
39HTLV-I infection_Homo sapiens_hsa051660.63785660
40RNA degradation_Homo sapiens_hsa030180.60491999
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56944930
42Bladder cancer_Homo sapiens_hsa052190.56473368
43Lysine degradation_Homo sapiens_hsa003100.54080590
44Leishmaniasis_Homo sapiens_hsa051400.54075415
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53311110
46Chemokine signaling pathway_Homo sapiens_hsa040620.52506514
47mTOR signaling pathway_Homo sapiens_hsa041500.47111924
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46264777
49Nitrogen metabolism_Homo sapiens_hsa009100.46121849
50Basal cell carcinoma_Homo sapiens_hsa052170.45570172
51Shigellosis_Homo sapiens_hsa051310.45094050
52Epstein-Barr virus infection_Homo sapiens_hsa051690.43477221
53Glioma_Homo sapiens_hsa052140.43107663
54Herpes simplex infection_Homo sapiens_hsa051680.42344410
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.41738190
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41624653
57Colorectal cancer_Homo sapiens_hsa052100.41619541
58Gap junction_Homo sapiens_hsa045400.40210258
59Renin-angiotensin system_Homo sapiens_hsa046140.39960763
60RNA polymerase_Homo sapiens_hsa030200.39537687
61TGF-beta signaling pathway_Homo sapiens_hsa043500.38479149
62Vitamin B6 metabolism_Homo sapiens_hsa007500.38477214
63Sulfur metabolism_Homo sapiens_hsa009200.38405912
64Hippo signaling pathway_Homo sapiens_hsa043900.37902368
65Biosynthesis of amino acids_Homo sapiens_hsa012300.36244888
66Pancreatic cancer_Homo sapiens_hsa052120.35963122
67Apoptosis_Homo sapiens_hsa042100.35926031
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35229866
69Prostate cancer_Homo sapiens_hsa052150.34527782
70Hepatitis B_Homo sapiens_hsa051610.33905717
71T cell receptor signaling pathway_Homo sapiens_hsa046600.32963673
72Proteoglycans in cancer_Homo sapiens_hsa052050.32562750
73Staphylococcus aureus infection_Homo sapiens_hsa051500.32416110
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30652430
75Endometrial cancer_Homo sapiens_hsa052130.30308715
76Basal transcription factors_Homo sapiens_hsa030220.30120037
77Influenza A_Homo sapiens_hsa051640.28443700
78FoxO signaling pathway_Homo sapiens_hsa040680.27817935
79Notch signaling pathway_Homo sapiens_hsa043300.27035804
80Antigen processing and presentation_Homo sapiens_hsa046120.27025420
81Phagosome_Homo sapiens_hsa041450.26771722
82Galactose metabolism_Homo sapiens_hsa000520.24983957
83Glutathione metabolism_Homo sapiens_hsa004800.24879260
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23763524
85Acute myeloid leukemia_Homo sapiens_hsa052210.23420776
86Pathways in cancer_Homo sapiens_hsa052000.22529129
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22437123
88Tight junction_Homo sapiens_hsa045300.21866804
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21518967
90Toxoplasmosis_Homo sapiens_hsa051450.21072442
91Purine metabolism_Homo sapiens_hsa002300.20881547
92Adherens junction_Homo sapiens_hsa045200.20775022
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20273587
94Hedgehog signaling pathway_Homo sapiens_hsa043400.19771647
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19649110
96Melanoma_Homo sapiens_hsa052180.19623094
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.19431089
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19061290
99Arachidonic acid metabolism_Homo sapiens_hsa005900.18999841
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18230848
101Endocytosis_Homo sapiens_hsa041440.17958584
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17708157
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17078243
104Focal adhesion_Homo sapiens_hsa045100.16984842
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16849614
106Sulfur relay system_Homo sapiens_hsa041220.16706351
107B cell receptor signaling pathway_Homo sapiens_hsa046620.16232793
108Viral myocarditis_Homo sapiens_hsa054160.15960029
109Thyroid cancer_Homo sapiens_hsa052160.15821447
110Osteoclast differentiation_Homo sapiens_hsa043800.14954897
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14891531
112Dorso-ventral axis formation_Homo sapiens_hsa043200.13959510
113HIF-1 signaling pathway_Homo sapiens_hsa040660.13866252
114Hematopoietic cell lineage_Homo sapiens_hsa046400.13074089
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.12893460
116Fatty acid elongation_Homo sapiens_hsa000620.12672941
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.12368964
118Pentose phosphate pathway_Homo sapiens_hsa000300.12330500
119AMPK signaling pathway_Homo sapiens_hsa041520.12195495
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12023304
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.11753692
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11726391
123Inositol phosphate metabolism_Homo sapiens_hsa005620.11314325
124Tuberculosis_Homo sapiens_hsa051520.10091972
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.09837841
126ECM-receptor interaction_Homo sapiens_hsa045120.09154854
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08926952
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.08758488
129Glycerolipid metabolism_Homo sapiens_hsa005610.08734187
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.08502321
131Choline metabolism in cancer_Homo sapiens_hsa052310.07897699
132Wnt signaling pathway_Homo sapiens_hsa043100.07720172
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07550924
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06784388
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.06544176
136VEGF signaling pathway_Homo sapiens_hsa043700.06273964
137Measles_Homo sapiens_hsa051620.05674039
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.05627622
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.05372810
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.04548302
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.04009588
142Platelet activation_Homo sapiens_hsa046110.03450969
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.03185301
144Insulin signaling pathway_Homo sapiens_hsa049100.03065977
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.02819074
146Renal cell carcinoma_Homo sapiens_hsa052110.02206784

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