HIST1H2BO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mucosal immune response (GO:0002385)9.36570738
2DNA replication-dependent nucleosome organization (GO:0034723)9.33157488
3DNA replication-dependent nucleosome assembly (GO:0006335)9.33157488
4antibacterial humoral response (GO:0019731)9.05549756
5organ or tissue specific immune response (GO:0002251)8.49102420
6antimicrobial humoral response (GO:0019730)8.27210242
7nuclear pore complex assembly (GO:0051292)7.93401116
8chromatin assembly (GO:0031497)7.58817673
9* nucleosome assembly (GO:0006334)7.38462491
10nuclear pore organization (GO:0006999)7.06276506
11* protein-DNA complex assembly (GO:0065004)6.28644951
12* nucleosome organization (GO:0034728)6.22314027
13regulation of histone H3-K9 methylation (GO:0051570)6.04241775
14pore complex assembly (GO:0046931)6.02997389
15chromatin assembly or disassembly (GO:0006333)5.64439188
16DNA unwinding involved in DNA replication (GO:0006268)5.60019697
17* protein-DNA complex subunit organization (GO:0071824)5.45963501
18DNA strand elongation involved in DNA replication (GO:0006271)5.14206867
19DNA strand elongation (GO:0022616)4.96960544
20mitotic chromosome condensation (GO:0007076)4.95094258
21protein localization to chromosome, centromeric region (GO:0071459)4.94809781
22DNA replication initiation (GO:0006270)4.82865975
23telomere maintenance via semi-conservative replication (GO:0032201)4.41741015
24mitotic sister chromatid segregation (GO:0000070)4.40210478
25sister chromatid segregation (GO:0000819)4.31072298
26negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.26613673
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.09833685
28regulation of sister chromatid cohesion (GO:0007063)4.09524062
29mitotic nuclear envelope disassembly (GO:0007077)3.99977438
30CENP-A containing nucleosome assembly (GO:0034080)3.99755083
31chromatin remodeling at centromere (GO:0031055)3.94120239
32telomere maintenance via recombination (GO:0000722)3.86671471
33DNA duplex unwinding (GO:0032508)3.80569448
34regulation of translational fidelity (GO:0006450)3.77308098
35protein localization to kinetochore (GO:0034501)3.75703865
36defense response to Gram-positive bacterium (GO:0050830)3.75169082
37nuclear envelope disassembly (GO:0051081)3.71731427
38membrane disassembly (GO:0030397)3.71731427
39mitotic recombination (GO:0006312)3.71133386
40DNA geometric change (GO:0032392)3.65244510
41V(D)J recombination (GO:0033151)3.62076186
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.56335827
43DNA synthesis involved in DNA repair (GO:0000731)3.39159486
44mitotic sister chromatid cohesion (GO:0007064)3.37225326
45non-recombinational repair (GO:0000726)3.36493320
46double-strand break repair via nonhomologous end joining (GO:0006303)3.36493320
47viral mRNA export from host cell nucleus (GO:0046784)3.35460704
48regulation of chromosome segregation (GO:0051983)3.31771817
49positive regulation of chromosome segregation (GO:0051984)3.20623675
50regulation of centrosome cycle (GO:0046605)3.19233022
51regulation of megakaryocyte differentiation (GO:0045652)3.17015700
52DNA conformation change (GO:0071103)3.15435009
53telomere maintenance (GO:0000723)3.07054593
54DNA replication checkpoint (GO:0000076)3.06916703
55nucleotide-excision repair, DNA gap filling (GO:0006297)3.06538676
56chromosome condensation (GO:0030261)3.06149831
57telomere organization (GO:0032200)3.06122254
58mitotic metaphase plate congression (GO:0007080)3.05816212
59DNA replication-independent nucleosome assembly (GO:0006336)3.04002144
60DNA replication-independent nucleosome organization (GO:0034724)3.04002144
61regulation of gene silencing (GO:0060968)3.02558775
62cellular protein complex localization (GO:0034629)3.02021671
63somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00786530
64somatic hypermutation of immunoglobulin genes (GO:0016446)3.00786530
65negative regulation of chromosome segregation (GO:0051985)2.99682097
66protein complex localization (GO:0031503)2.98190558
67kinetochore organization (GO:0051383)2.92957720
68positive regulation of mitotic sister chromatid separation (GO:1901970)2.88931433
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.88931433
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.88931433
71meiotic chromosome segregation (GO:0045132)2.87154588
72regulation of sister chromatid segregation (GO:0033045)2.87100462
73regulation of mitotic sister chromatid separation (GO:0010965)2.87100462
74regulation of mitotic sister chromatid segregation (GO:0033047)2.87100462
75ATP-dependent chromatin remodeling (GO:0043044)2.86967392
76regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86390027
77regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86390027
78telomere maintenance via telomere lengthening (GO:0010833)2.86218929
79somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.84559795
80somatic cell DNA recombination (GO:0016444)2.84559795
81histone exchange (GO:0043486)2.84035572
82proline biosynthetic process (GO:0006561)2.82577950
83regulation of mammary gland epithelial cell proliferation (GO:0033599)2.81503940
84spindle checkpoint (GO:0031577)2.80679345
85protein localization to chromosome (GO:0034502)2.80502892
86nuclear envelope organization (GO:0006998)2.80451968
87negative regulation of mitotic sister chromatid separation (GO:2000816)2.80045896
88negative regulation of sister chromatid segregation (GO:0033046)2.80045896
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.80045896
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.80045896
91negative regulation of mitotic sister chromatid segregation (GO:0033048)2.80045896
92mitotic spindle assembly checkpoint (GO:0007094)2.79597312
93metaphase plate congression (GO:0051310)2.78541886
94rRNA transcription (GO:0009303)2.77672805
95regulation of centrosome duplication (GO:0010824)2.76434495
96spindle assembly checkpoint (GO:0071173)2.76386942
97DNA packaging (GO:0006323)2.75812772
98peptidyl-lysine dimethylation (GO:0018027)2.74773016
99peptidyl-arginine omega-N-methylation (GO:0035247)2.73725555
100innate immune response in mucosa (GO:0002227)11.4300503

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.07493733
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.34845716
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.96987070
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.87341597
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.59597528
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70298895
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.61410483
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50480601
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.48829915
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.29593694
11MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19701574
12* SOX2_16153702_ChIP-ChIP_HESCs_Human2.19398620
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.9309061
14MYC_18555785_ChIP-Seq_MESCs_Mouse1.95431312
15CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.92882414
16* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.90938264
17HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.85921857
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82604500
19NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80209273
20MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72344666
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70957124
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65909005
23GATA1_22025678_ChIP-Seq_K562_Human1.64130464
24ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57988705
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57460746
26AR_21909140_ChIP-Seq_LNCAP_Human1.55000686
27ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52292866
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48246784
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47847515
30SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.44195843
31IRF1_19129219_ChIP-ChIP_H3396_Human1.43672732
32MYC_22102868_ChIP-Seq_BL_Human1.33817803
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32467510
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.29036741
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24639642
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19183952
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18764657
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18362504
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17766774
40KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17740128
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16280650
42* VDR_23849224_ChIP-Seq_CD4+_Human1.15223640
43* NANOG_16153702_ChIP-ChIP_HESCs_Human1.15006448
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12433466
45VDR_21846776_ChIP-Seq_THP-1_Human1.11922722
46* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09956654
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08933637
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06591986
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06350414
50SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04737690
51ELK1_19687146_ChIP-ChIP_HELA_Human1.04534201
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02815624
53DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02112545
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01689984
55XRN2_22483619_ChIP-Seq_HELA_Human1.01220427
56SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99673420
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99302475
58PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98779559
59ETS1_22383799_ChIP-Seq_G1ME_Mouse0.98760382
60ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96233346
61BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93779729
62NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93524821
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91301871
64CIITA_25753668_ChIP-Seq_RAJI_Human0.91264594
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90674371
66MYC_18940864_ChIP-ChIP_HL60_Human0.89471258
67DCP1A_22483619_ChIP-Seq_HELA_Human0.89401578
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89053569
69TP63_17297297_ChIP-ChIP_HaCaT_Human0.88786689
70FOXP3_21729870_ChIP-Seq_TREG_Human0.88129105
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87518667
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86768725
73NOTCH1_21737748_ChIP-Seq_TLL_Human0.84966226
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.83357851
75ZNF263_19887448_ChIP-Seq_K562_Human0.82485902
76ETS1_20019798_ChIP-Seq_JURKAT_Human0.81234883
77* MAF_26560356_Chip-Seq_TH1_Human0.79823794
78PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79475164
79MYCN_18555785_ChIP-Seq_MESCs_Mouse0.78940826
80PKCTHETA_26484144_Chip-Seq_BREAST_Human0.77702045
81ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76470654
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.76397676
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76360844
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74981086
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74362271
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.73032728
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.68918935
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.68894241
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.68179528
90TCF3_18692474_ChIP-Seq_MESCs_Mouse0.66965267
91TTF2_22483619_ChIP-Seq_HELA_Human0.66923104
92EST1_17652178_ChIP-ChIP_JURKAT_Human0.66582445
93ELF1_17652178_ChIP-ChIP_JURKAT_Human0.66042627
94KDM5A_27292631_Chip-Seq_BREAST_Human0.65904254
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.63877943
96STAT3_1855785_ChIP-Seq_MESCs_Mouse0.63362506
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.63252570
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.63042779
99* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.61836185
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.60053635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.05645073
2MP0008057_abnormal_DNA_replication4.79894126
3MP0003111_abnormal_nucleus_morphology4.34061876
4MP0003077_abnormal_cell_cycle3.96579729
5MP0003693_abnormal_embryo_hatching3.73938811
6MP0004957_abnormal_blastocyst_morpholog3.50859033
7MP0010352_gastrointestinal_tract_polyps3.49874227
8MP0002009_preneoplasia3.23437294
9MP0008058_abnormal_DNA_repair2.41621262
10MP0008932_abnormal_embryonic_tissue2.38105944
11MP0009697_abnormal_copulation2.37659918
12MP0010307_abnormal_tumor_latency2.37546080
13MP0002396_abnormal_hematopoietic_system2.36111664
14MP0010234_abnormal_vibrissa_follicle2.33362133
15MP0003763_abnormal_thymus_physiology2.27876170
16MP0008007_abnormal_cellular_replicative2.24689408
17MP0002877_abnormal_melanocyte_morpholog2.08384379
18MP0000350_abnormal_cell_proliferation2.02168423
19MP0001661_extended_life_span1.96133044
20MP0002166_altered_tumor_susceptibility1.84869661
21MP0004808_abnormal_hematopoietic_stem1.83759390
22MP0003786_premature_aging1.81142016
23MP0004185_abnormal_adipocyte_glucose1.72492616
24MP0000490_abnormal_crypts_of1.71020189
25MP0001730_embryonic_growth_arrest1.69649314
26MP0005645_abnormal_hypothalamus_physiol1.69344563
27MP0000537_abnormal_urethra_morphology1.64321761
28MP0000685_abnormal_immune_system1.61099031
29MP0005083_abnormal_biliary_tract1.50996830
30MP0005076_abnormal_cell_differentiation1.49249425
31MP0000313_abnormal_cell_death1.48180468
32MP0002006_tumorigenesis1.47419111
33MP0001672_abnormal_embryogenesis/_devel1.46744320
34MP0005380_embryogenesis_phenotype1.46744320
35MP0003705_abnormal_hypodermis_morpholog1.42193112
36MP0002019_abnormal_tumor_incidence1.40912577
37MP0002398_abnormal_bone_marrow1.38535514
38MP0002086_abnormal_extraembryonic_tissu1.37987352
39MP0003984_embryonic_growth_retardation1.37265461
40MP0000703_abnormal_thymus_morphology1.36688704
41MP0002080_prenatal_lethality1.33293412
42MP0002088_abnormal_embryonic_growth/wei1.30619996
43MP0001697_abnormal_embryo_size1.25970146
44MP0002722_abnormal_immune_system1.21041932
45MP0002084_abnormal_developmental_patter1.19054592
46MP0004233_abnormal_muscle_weight1.15708755
47MP0003941_abnormal_skin_development1.14222141
48MP0000358_abnormal_cell_content/1.14061656
49MP0001835_abnormal_antigen_presentation1.11948744
50MP0002163_abnormal_gland_morphology1.11715174
51MP0002085_abnormal_embryonic_tissue1.08238030
52MP0003718_maternal_effect1.07809347
53MP0006035_abnormal_mitochondrial_morpho1.07518198
54MP0001849_ear_inflammation1.05244308
55MP0003656_abnormal_erythrocyte_physiolo1.05042420
56MP0002697_abnormal_eye_size1.04272992
57MP0001727_abnormal_embryo_implantation1.02939008
58MP0000689_abnormal_spleen_morphology1.02092660
59MP0005671_abnormal_response_to1.00404801
60MP0002092_abnormal_eye_morphology1.00016241
61MP0005220_abnormal_exocrine_pancreas0.98759200
62MP0002429_abnormal_blood_cell0.92272642
63MP0005623_abnormal_meninges_morphology0.90585360
64MP0001800_abnormal_humoral_immune0.89782279
65MP0004381_abnormal_hair_follicle0.86402584
66MP0005451_abnormal_body_composition0.83667364
67MP0005384_cellular_phenotype0.82070544
68MP0005501_abnormal_skin_physiology0.81840418
69MP0002111_abnormal_tail_morphology0.81402948
70MP0005621_abnormal_cell_physiology0.81373537
71MP0003937_abnormal_limbs/digits/tail_de0.81363292
72MP0004197_abnormal_fetal_growth/weight/0.78583608
73MP0000716_abnormal_immune_system0.75626967
74MP0000428_abnormal_craniofacial_morphol0.68733918
75MP0003385_abnormal_body_wall0.68494338
76MP0001915_intracranial_hemorrhage0.68081540
77MP0003890_abnormal_embryonic-extraembry0.67605505
78MP0003453_abnormal_keratinocyte_physiol0.67586973
79MP0000733_abnormal_muscle_development0.66998633
80MP0004947_skin_inflammation0.66732035
81MP0002060_abnormal_skin_morphology0.66211748
82MP0003315_abnormal_perineum_morphology0.64993831
83MP0000015_abnormal_ear_pigmentation0.64186663
84MP0001216_abnormal_epidermal_layer0.63677518
85MP0009931_abnormal_skin_appearance0.63312553
86MP0003566_abnormal_cell_adhesion0.62859362
87MP0003699_abnormal_female_reproductive0.62822546
88MP0001191_abnormal_skin_condition0.62729623
89MP0004147_increased_porphyrin_level0.61663249
90MP0002160_abnormal_reproductive_system0.60586756
91MP0009278_abnormal_bone_marrow0.60349543
92MP0000477_abnormal_intestine_morphology0.59092246
93MP0005464_abnormal_platelet_physiology0.58481664
94MP0001348_abnormal_lacrimal_gland0.58410624
95MP0001929_abnormal_gametogenesis0.57844706
96MP0005647_abnormal_sex_gland0.57356407
97MP0002420_abnormal_adaptive_immunity0.57147098
98MP0005000_abnormal_immune_tolerance0.56889053
99MP0002098_abnormal_vibrissa_morphology0.56392404
100MP0002210_abnormal_sex_determination0.56105770

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.79519304
2Chromsome breakage (HP:0040012)5.20982366
3IgA deficiency (HP:0002720)5.16953140
4IgM deficiency (HP:0002850)5.15891151
5Colitis (HP:0002583)3.75377220
6Abnormality of chromosome stability (HP:0003220)3.27306068
7Gastrointestinal stroma tumor (HP:0100723)3.16531492
8Abnormality of the preputium (HP:0100587)3.11287928
9Squamous cell carcinoma (HP:0002860)3.05355538
10Medulloblastoma (HP:0002885)2.99199034
11Aplasia/Hypoplasia of the uvula (HP:0010293)2.95034640
12Insomnia (HP:0100785)2.85005366
13B lymphocytopenia (HP:0010976)2.82976402
14Abnormality of the carotid arteries (HP:0005344)2.82323664
15Microvesicular hepatic steatosis (HP:0001414)2.81278088
16Reticulocytopenia (HP:0001896)2.80348044
17Cellulitis (HP:0100658)2.73432079
18Nephroblastoma (Wilms tumor) (HP:0002667)2.72148769
19Hyperacusis (HP:0010780)2.67414262
20Meckel diverticulum (HP:0002245)2.57793000
21Abnormality of the ileum (HP:0001549)2.54490393
22Embryonal renal neoplasm (HP:0011794)2.50787570
23Basal cell carcinoma (HP:0002671)2.49043880
2411 pairs of ribs (HP:0000878)2.45799006
25Thyroiditis (HP:0100646)2.37922673
26Aplasia/Hypoplasia of the sacrum (HP:0008517)2.37767791
27Birth length less than 3rd percentile (HP:0003561)2.37312863
28Lymphopenia (HP:0001888)2.35283829
29Small intestinal stenosis (HP:0012848)2.32894545
30Duodenal stenosis (HP:0100867)2.32894545
31Abnormality of cells of the lymphoid lineage (HP:0012140)2.32777460
32Orthostatic hypotension (HP:0001278)2.30964131
33Abnormality of B cell number (HP:0010975)2.28870705
34Dry hair (HP:0011359)2.26538905
35Clubbing of toes (HP:0100760)2.25648124
36Lymphoma (HP:0002665)2.25162752
37Renovascular hypertension (HP:0100817)2.22351061
38Ankyloglossia (HP:0010296)2.20914018
39Myelodysplasia (HP:0002863)2.20387547
40Inflammation of the large intestine (HP:0002037)2.16868761
41Selective tooth agenesis (HP:0001592)2.16620699
42Leiomyosarcoma (HP:0100243)2.15842510
43Uterine leiomyosarcoma (HP:0002891)2.15842510
44Cafe-au-lait spot (HP:0000957)2.15708211
45Abnormality of pyrimidine metabolism (HP:0004353)2.15692475
46Elfin facies (HP:0004428)2.11188303
47Agammaglobulinemia (HP:0004432)2.09358293
48Abnormality of DNA repair (HP:0003254)2.07610041
49Gastrointestinal inflammation (HP:0004386)2.06868936
50Combined immunodeficiency (HP:0005387)2.06811461
51Recurrent sinusitis (HP:0011108)2.04562302
52Acute lymphatic leukemia (HP:0006721)2.03916070
53Gastrointestinal carcinoma (HP:0002672)2.02437987
54Malignant gastrointestinal tract tumors (HP:0006749)2.02437987
55Recurrent viral infections (HP:0004429)2.01927837
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.01809994
57Short 4th metacarpal (HP:0010044)2.01809994
58Spastic diplegia (HP:0001264)2.01694776
59Autoimmune hemolytic anemia (HP:0001890)2.00368004
60Abnormality of cells of the erythroid lineage (HP:0012130)1.98892150
61Entropion (HP:0000621)1.97147181
62Prominent nose (HP:0000448)1.96930472
63Overriding aorta (HP:0002623)1.96457414
64Abnormality of the fingertips (HP:0001211)1.94739995
65Erythema (HP:0010783)1.92740541
66Abnormality of oral frenula (HP:0000190)1.92674029
67Hypergonadotropic hypogonadism (HP:0000815)1.92518189
68Ureteral duplication (HP:0000073)1.91892453
69Progressive muscle weakness (HP:0003323)1.91160504
70Ridged nail (HP:0001807)1.89569042
71Deep philtrum (HP:0002002)1.89562422
72Colon cancer (HP:0003003)1.89493973
73Sandal gap (HP:0001852)1.88423816
74Increased nuchal translucency (HP:0010880)1.87389700
75Duplicated collecting system (HP:0000081)1.86194683
76Poikiloderma (HP:0001029)1.86178638
77Chronic diarrhea (HP:0002028)1.85994572
78Abnormality of the duodenum (HP:0002246)1.85584628
79Leukopenia (HP:0001882)1.84227337
80Viral hepatitis (HP:0006562)1.83700015
81Missing ribs (HP:0000921)1.83432793
82Short thumb (HP:0009778)1.81952255
83Onycholysis (HP:0001806)1.80874903
84Hepatitis (HP:0012115)1.80846032
85Bladder carcinoma (HP:0002862)1.80802198
86Bladder neoplasm (HP:0009725)1.80802198
87Subacute progressive viral hepatitis (HP:0006572)1.79552138
88High anterior hairline (HP:0009890)1.79034482
89Abnormality of the parietal bone (HP:0002696)1.78981388
90Abnormality of the distal phalanx of the thumb (HP:0009617)1.77672376
91Prostate neoplasm (HP:0100787)1.77268391
92Abnormality of reticulocytes (HP:0004312)1.77226094
93Poikilocytosis (HP:0004447)1.77036444
94Astrocytoma (HP:0009592)1.76318818
95Abnormality of the astrocytes (HP:0100707)1.76318818
96Severe combined immunodeficiency (HP:0004430)1.75764898
97Neoplasm of striated muscle (HP:0009728)1.75448660
98Abnormality of chromosome segregation (HP:0002916)1.74817556
99Arteriovenous malformation (HP:0100026)1.74134865
100Recurrent bronchitis (HP:0002837)1.73505731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK9.42267147
2TLK18.86435570
3VRK15.36725203
4RPS6KA53.21285735
5DAPK32.59673923
6CDC72.05615468
7AURKA1.94366188
8SMG11.91256642
9STK41.88027608
10BUB11.87296123
11EEF2K1.68119240
12SCYL21.63681588
13CHEK21.48514236
14AURKB1.39051424
15PIM11.36967945
16TTK1.32475660
17TAF11.28145559
18PBK1.25123528
19SRPK11.22741435
20MAP3K101.12788962
21PKN11.12192359
22NEK11.01310478
23MAP3K80.96997032
24BRSK20.90433391
25ICK0.86379345
26RPS6KB20.84809583
27TRIB30.82275876
28NME20.76795701
29CDK120.76340765
30ATR0.76049657
31PRPF4B0.75964638
32PLK40.75511713
33BRAF0.69942007
34TSSK60.66146076
35CDK70.61060326
36BTK0.60931591
37WEE10.60364500
38CCNB10.60093949
39AKT20.59428535
40PLK10.58887993
41EIF2AK30.57515381
42MELK0.55120032
43MAPK110.52689032
44CDK80.50760119
45CHEK10.49261528
46NEK90.48282613
47PRKAA10.47242111
48NEK20.42923671
49TTN0.42547885
50CDK40.41023704
51CDK60.40688884
52STK160.37907224
53ATM0.37714480
54RAF10.37467071
55PIM20.36860767
56BRSK10.35627941
57PKN20.35498372
58PLK30.34468182
59MST1R0.32219437
60CDK20.32050624
61NLK0.31219035
62PRKCQ0.29251893
63BRD40.28997578
64JAK20.27197489
65IRAK30.27103045
66CSNK1G30.26329319
67CSNK1A1L0.25231990
68MAPKAPK50.25182784
69PAK10.24586701
70CDK10.23495166
71SYK0.23404063
72BLK0.23216413
73CSNK1G10.22777844
74IRAK40.21805951
75MAP2K30.20652438
76MAP2K70.18843816
77PIK3CG0.18256773
78STK30.17786500
79EIF2AK20.17688529
80KDR0.16565609
81CAMK1D0.16565153
82BCKDK0.15242857
83MST40.14863218
84TRPM70.14348513
85RPS6KA40.14177095
86MTOR0.13638433
87CAMK40.11829070
88STK240.10987887
89CDK90.10669901
90RPS6KB10.10351370
91MAP3K40.10023439
92KSR20.09216933
93MAP2K20.07860664
94PRKCI0.07229173
95CSNK2A20.07206074
96STK100.06044459
97LYN0.05801506
98MAPK140.05605136
99PRKDC0.05604593
100MAP3K20.05287753

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050348.01561381
2* Viral carcinogenesis_Homo sapiens_hsa052033.60669972
3DNA replication_Homo sapiens_hsa030302.83445223
4* Systemic lupus erythematosus_Homo sapiens_hsa0532211.2441279
5Mismatch repair_Homo sapiens_hsa034301.95246360
6Transcriptional misregulation in cancer_Homo sapiens_hsa052021.89217655
7Cell cycle_Homo sapiens_hsa041101.64691447
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53326308
9Non-homologous end-joining_Homo sapiens_hsa034501.47373708
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39799192
11Base excision repair_Homo sapiens_hsa034101.25168768
12Nucleotide excision repair_Homo sapiens_hsa034201.23001149
13Fanconi anemia pathway_Homo sapiens_hsa034601.20319469
14Homologous recombination_Homo sapiens_hsa034401.15154844
15Primary immunodeficiency_Homo sapiens_hsa053401.07401073
16RNA transport_Homo sapiens_hsa030130.85531453
17Biosynthesis of amino acids_Homo sapiens_hsa012300.78344111
18Pyrimidine metabolism_Homo sapiens_hsa002400.77548714
19Pentose phosphate pathway_Homo sapiens_hsa000300.76191139
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75645796
21p53 signaling pathway_Homo sapiens_hsa041150.74987762
22Spliceosome_Homo sapiens_hsa030400.72542035
23Intestinal immune network for IgA production_Homo sapiens_hsa046720.71249567
24B cell receptor signaling pathway_Homo sapiens_hsa046620.70425556
25Thyroid cancer_Homo sapiens_hsa052160.69334374
26One carbon pool by folate_Homo sapiens_hsa006700.69037266
27Ribosome_Homo sapiens_hsa030100.67657923
28Non-small cell lung cancer_Homo sapiens_hsa052230.67540978
29Vitamin B6 metabolism_Homo sapiens_hsa007500.63159822
30Sulfur relay system_Homo sapiens_hsa041220.61021326
31Chronic myeloid leukemia_Homo sapiens_hsa052200.60561313
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58207927
33Pancreatic cancer_Homo sapiens_hsa052120.57998206
34HTLV-I infection_Homo sapiens_hsa051660.55320628
35Central carbon metabolism in cancer_Homo sapiens_hsa052300.54436022
36Colorectal cancer_Homo sapiens_hsa052100.53034427
37Bladder cancer_Homo sapiens_hsa052190.52376758
38Epstein-Barr virus infection_Homo sapiens_hsa051690.50148631
39Selenocompound metabolism_Homo sapiens_hsa004500.49440664
40Asthma_Homo sapiens_hsa053100.48851244
41Allograft rejection_Homo sapiens_hsa053300.47689469
42Small cell lung cancer_Homo sapiens_hsa052220.46695719
43MicroRNAs in cancer_Homo sapiens_hsa052060.46678353
44Autoimmune thyroid disease_Homo sapiens_hsa053200.46452194
45RNA polymerase_Homo sapiens_hsa030200.45126385
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45088117
47Herpes simplex infection_Homo sapiens_hsa051680.44795998
48Glioma_Homo sapiens_hsa052140.42906931
49Carbon metabolism_Homo sapiens_hsa012000.42892702
50Viral myocarditis_Homo sapiens_hsa054160.42561432
51Purine metabolism_Homo sapiens_hsa002300.39982438
52mRNA surveillance pathway_Homo sapiens_hsa030150.39912183
53Endometrial cancer_Homo sapiens_hsa052130.38943461
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38371734
55Fructose and mannose metabolism_Homo sapiens_hsa000510.37684812
56Basal cell carcinoma_Homo sapiens_hsa052170.37076568
57Apoptosis_Homo sapiens_hsa042100.33969599
58Graft-versus-host disease_Homo sapiens_hsa053320.31764615
59Hepatitis B_Homo sapiens_hsa051610.31726778
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.31125352
61N-Glycan biosynthesis_Homo sapiens_hsa005100.27842251
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27809323
63Inositol phosphate metabolism_Homo sapiens_hsa005620.27066330
64Prostate cancer_Homo sapiens_hsa052150.26538220
65RNA degradation_Homo sapiens_hsa030180.26314282
66Acute myeloid leukemia_Homo sapiens_hsa052210.25361912
67Lysine degradation_Homo sapiens_hsa003100.23946413
68Galactose metabolism_Homo sapiens_hsa000520.23560331
69Hematopoietic cell lineage_Homo sapiens_hsa046400.23449671
70Oocyte meiosis_Homo sapiens_hsa041140.23228601
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22529660
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21505363
73Influenza A_Homo sapiens_hsa051640.21405874
74Measles_Homo sapiens_hsa051620.20305431
75Type I diabetes mellitus_Homo sapiens_hsa049400.20302401
76Antigen processing and presentation_Homo sapiens_hsa046120.20240257
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19009353
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18350671
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18101776
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18028355
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17980436
82Melanoma_Homo sapiens_hsa052180.17877145
83Basal transcription factors_Homo sapiens_hsa030220.17403681
84HIF-1 signaling pathway_Homo sapiens_hsa040660.16924849
85TGF-beta signaling pathway_Homo sapiens_hsa043500.15486127
86Arginine biosynthesis_Homo sapiens_hsa002200.14525737
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.14372975
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13919705
89Leishmaniasis_Homo sapiens_hsa051400.13911634
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13576997
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13300597
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13181546
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.12955463
94Adherens junction_Homo sapiens_hsa045200.12050728
95Pyruvate metabolism_Homo sapiens_hsa006200.11293713
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11120552
97ErbB signaling pathway_Homo sapiens_hsa040120.10053741
98Hippo signaling pathway_Homo sapiens_hsa043900.09633177
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.07390607
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06531235

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