HIST1H2BN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1porphyrin-containing compound biosynthetic process (GO:0006779)9.32328545
2heme biosynthetic process (GO:0006783)8.37741636
3antibacterial humoral response (GO:0019731)8.36958570
4erythrocyte maturation (GO:0043249)8.30552872
5tetrapyrrole biosynthetic process (GO:0033014)8.25135865
6hemoglobin metabolic process (GO:0020027)8.22551519
7innate immune response in mucosa (GO:0002227)8.20794960
8antimicrobial humoral response (GO:0019730)7.82095590
9* nucleosome assembly (GO:0006334)7.47893895
10chromatin assembly (GO:0031497)7.36994790
11DNA replication-dependent nucleosome organization (GO:0034723)7.21387349
12DNA replication-dependent nucleosome assembly (GO:0006335)7.21387349
13regulation of response to osmotic stress (GO:0047484)7.17927394
14porphyrin-containing compound metabolic process (GO:0006778)7.01276832
15response to methylmercury (GO:0051597)6.82877914
16erythrocyte development (GO:0048821)6.64280984
17mucosal immune response (GO:0002385)6.46489175
18* nucleosome organization (GO:0034728)6.45900219
19* protein-DNA complex assembly (GO:0065004)6.24513703
20heme metabolic process (GO:0042168)6.22366163
21organ or tissue specific immune response (GO:0002251)6.11796882
22regulation of DNA endoreduplication (GO:0032875)5.62500375
23response to insecticide (GO:0017085)5.61304421
24* protein-DNA complex subunit organization (GO:0071824)5.58738886
25sister chromatid segregation (GO:0000819)5.55528829
26DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla5.54782244
27mitotic sister chromatid segregation (GO:0000070)5.43222062
28microtubule depolymerization (GO:0007019)5.41149153
29mitotic chromosome condensation (GO:0007076)5.40829493
30response to lead ion (GO:0010288)5.28432371
31regulation of histone H3-K9 methylation (GO:0051570)5.25016272
32chromatin assembly or disassembly (GO:0006333)5.20442772
33negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)5.14708827
34DNA damage response, signal transduction resulting in transcription (GO:0042772)4.92010511
35protein localization to kinetochore (GO:0034501)4.73936915
36positive regulation of mitotic sister chromatid separation (GO:1901970)4.70837551
37positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.70837551
38positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.70837551
39protein localization to chromosome, centromeric region (GO:0071459)4.59180764
40cytoskeletal anchoring at plasma membrane (GO:0007016)4.55573465
41erythrocyte differentiation (GO:0030218)4.48846235
42DNA unwinding involved in DNA replication (GO:0006268)4.44355133
43kinetochore organization (GO:0051383)4.40640896
44tetrapyrrole metabolic process (GO:0033013)4.38584078
45myeloid cell development (GO:0061515)4.38014551
46regulation of centriole replication (GO:0046599)4.26540834
47positive regulation of chromosome segregation (GO:0051984)4.11300116
48meiotic chromosome segregation (GO:0045132)4.07118817
49somatic hypermutation of immunoglobulin genes (GO:0016446)4.02096516
50somatic diversification of immune receptors via somatic mutation (GO:0002566)4.02096516
51regulation of megakaryocyte differentiation (GO:0045652)3.98483492
52replication fork processing (GO:0031297)3.97381669
53response to arsenic-containing substance (GO:0046685)3.96826173
54attachment of spindle microtubules to kinetochore (GO:0008608)3.94067604
55pigment biosynthetic process (GO:0046148)3.87958633
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.86616719
57one-carbon compound transport (GO:0019755)3.82286990
58nuclear pore organization (GO:0006999)3.75980738
59regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.75184767
60nuclear pore complex assembly (GO:0051292)3.74698113
61maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.68525586
62regulation of centrosome cycle (GO:0046605)3.63251884
63regulation of centrosome duplication (GO:0010824)3.62604781
64very-low-density lipoprotein particle assembly (GO:0034379)3.57435142
65viral mRNA export from host cell nucleus (GO:0046784)3.57120619
66pseudouridine synthesis (GO:0001522)3.50763435
67chromosome condensation (GO:0030261)3.47514114
68DNA replication initiation (GO:0006270)3.46919414
69regulation of sister chromatid cohesion (GO:0007063)3.45125642
70protein K6-linked ubiquitination (GO:0085020)3.44272825
71DNA deamination (GO:0045006)3.37863662
72maturation of 5.8S rRNA (GO:0000460)3.35698702
73defense response to Gram-positive bacterium (GO:0050830)3.32691844
74protein localization to chromosome (GO:0034502)3.28457158
75regulation of hematopoietic progenitor cell differentiation (GO:1901532)3.27907268
76regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27259084
77CENP-A containing nucleosome assembly (GO:0034080)3.27125833
78chromosome segregation (GO:0007059)3.26091998
79microtubule polymerization or depolymerization (GO:0031109)3.25066837
80DNA replication checkpoint (GO:0000076)3.18735406
81mitotic sister chromatid cohesion (GO:0007064)3.18633917
82mitochondrial RNA metabolic process (GO:0000959)3.17995513
83positive regulation of erythrocyte differentiation (GO:0045648)3.17484362
84chromatin remodeling at centromere (GO:0031055)3.17359537
85reciprocal meiotic recombination (GO:0007131)3.17302183
86reciprocal DNA recombination (GO:0035825)3.17302183
87kinetochore assembly (GO:0051382)3.17162256
88double-strand break repair via homologous recombination (GO:0000724)3.14419255
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.13821437
90mitochondrial respiratory chain complex I assembly (GO:0032981)3.13821437
91NADH dehydrogenase complex assembly (GO:0010257)3.13821437
92recombinational repair (GO:0000725)3.12216913
93DNA replication-independent nucleosome organization (GO:0034724)3.10649242
94DNA replication-independent nucleosome assembly (GO:0006336)3.10649242
95replicative senescence (GO:0090399)3.10308502
96bicarbonate transport (GO:0015701)3.07614242
97negative regulation of histone methylation (GO:0031061)3.07084932
98establishment of chromosome localization (GO:0051303)3.06416371
99actin filament capping (GO:0051693)3.06159769
100telomere maintenance via recombination (GO:0000722)3.04831361
101translesion synthesis (GO:0019985)3.04324156
102mitotic metaphase plate congression (GO:0007080)3.00719391
103DNA strand elongation involved in DNA replication (GO:0006271)3.00535366
104metaphase plate congression (GO:0051310)3.00234654
105pigment metabolic process (GO:0042440)2.98992054
106regulation of spindle organization (GO:0090224)2.95717397
107definitive hemopoiesis (GO:0060216)2.95471035
108tRNA modification (GO:0006400)2.93731568
109pore complex assembly (GO:0046931)2.93387332
110DNA synthesis involved in DNA repair (GO:0000731)2.93322506
111mitotic nuclear envelope disassembly (GO:0007077)2.92729028
112telomere organization (GO:0032200)2.90449054
113DNA strand elongation (GO:0022616)2.89700966
114histone exchange (GO:0043486)2.88461609
115mitotic G2/M transition checkpoint (GO:0044818)2.87770611
116DNA packaging (GO:0006323)2.87352680
117telomere maintenance (GO:0000723)2.86940156
118mitochondrial respiratory chain complex assembly (GO:0033108)2.86558408
119nucleotide-excision repair, DNA gap filling (GO:0006297)2.86431293
120DNA geometric change (GO:0032392)2.85207887
121regulation of gene silencing (GO:0060968)2.84719549
122postreplication repair (GO:0006301)2.84293937
123DNA duplex unwinding (GO:0032508)2.83632925
124mitotic recombination (GO:0006312)2.82935000
125regulation of mitotic spindle organization (GO:0060236)2.82437358
126folic acid-containing compound biosynthetic process (GO:0009396)2.80573353
127prenylation (GO:0097354)2.79617715
128protein prenylation (GO:0018342)2.79617715
129telomere maintenance via semi-conservative replication (GO:0032201)2.79167957
130mismatch repair (GO:0006298)2.77991302
131negative regulation of B cell apoptotic process (GO:0002903)2.74813298
132synapsis (GO:0007129)2.73648027
133protein complex biogenesis (GO:0070271)2.73238908
134telomere maintenance via telomere lengthening (GO:0010833)2.69074824
135DNA double-strand break processing (GO:0000729)2.66346300
136somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.65681764
137isotype switching (GO:0045190)2.65681764
138somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.65681764
139pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.61944977
140RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61931746
141somatic diversification of immunoglobulins (GO:0016445)2.61773708
142tRNA processing (GO:0008033)2.58961628
143somatic recombination of immunoglobulin gene segments (GO:0016447)2.57632108
144DNA recombination (GO:0006310)2.55022431
145rRNA catabolic process (GO:0016075)2.50558045
146tRNA metabolic process (GO:0006399)2.50125627
147resolution of meiotic recombination intermediates (GO:0000712)2.47142201
148methionine biosynthetic process (GO:0009086)2.46472054
149rRNA modification (GO:0000154)2.45960701
150somatic diversification of immune receptors (GO:0002200)2.44701352
151somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.40262750
152protoporphyrinogen IX metabolic process (GO:0046501)14.0475001
153protoporphyrinogen IX biosynthetic process (GO:0006782)12.5991284

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.19774844
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.18234937
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.04730630
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.44593852
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53748243
6* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.02198775
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99549071
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.93230080
9GATA1_22025678_ChIP-Seq_K562_Human2.89854573
10* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.80173646
11GATA1_19941826_ChIP-Seq_K562_Human2.47230199
12SOX2_16153702_ChIP-ChIP_HESCs_Human2.45109582
13IRF1_19129219_ChIP-ChIP_H3396_Human2.33302780
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32504262
15MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.31790038
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.28150393
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10707752
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09658844
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.01683806
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse13.6206254
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.97887096
22* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.96615925
23KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.90842237
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.88448982
25GATA1_19941827_ChIP-Seq_MEL_Mouse1.82915132
26CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.76510279
27MYC_18940864_ChIP-ChIP_HL60_Human1.68652818
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.66407643
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.64134923
30AR_21909140_ChIP-Seq_LNCAP_Human1.63608920
31SCL_19346495_ChIP-Seq_HPC-7_Human1.61666483
32HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.54604238
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53075792
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.49500245
35SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.47193235
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43213693
37FOXP3_21729870_ChIP-Seq_TREG_Human1.37659738
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.36584657
39* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36316108
40ZNF274_21170338_ChIP-Seq_K562_Hela1.34648453
41* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33067815
42GATA2_19941826_ChIP-Seq_K562_Human1.31282104
43* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30460343
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.28626113
45* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28567622
46* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28405400
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25730359
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24467493
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21251505
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20660629
51* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17908739
52* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17791025
53EWS_26573619_Chip-Seq_HEK293_Human1.17579378
54* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16489923
55* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14164852
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.13544851
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11029423
58CIITA_25753668_ChIP-Seq_RAJI_Human1.10982928
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10382986
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08626145
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07996412
62MYC_22102868_ChIP-Seq_BL_Human1.07583505
63* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05708462
64DCP1A_22483619_ChIP-Seq_HELA_Human1.03898463
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02890419
66* VDR_23849224_ChIP-Seq_CD4+_Human1.02856383
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01611904
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.00746098
69* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99693491
70GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99539008
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98655115
72IGF1R_20145208_ChIP-Seq_DFB_Human0.98000620
73VDR_21846776_ChIP-Seq_THP-1_Human0.95803817
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95148435
75* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93887968
76* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.92998979
77XRN2_22483619_ChIP-Seq_HELA_Human0.90044028
78* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89838649
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88375200
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88236021
81ZNF263_19887448_ChIP-Seq_K562_Human0.86857272
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.85855353
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84662681
84KDM5A_27292631_Chip-Seq_BREAST_Human0.82753609
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82373541
86PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82168660
87MYC_18555785_ChIP-Seq_MESCs_Mouse0.82128381
88TTF2_22483619_ChIP-Seq_HELA_Human0.81618862
89ELK1_19687146_ChIP-ChIP_HELA_Human0.81049382
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80721748
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80153001
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79441696
93ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78476848
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.78086488
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.76164469
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.75672043
97GABP_19822575_ChIP-Seq_HepG2_Human0.75401205
98MYC_19079543_ChIP-ChIP_MESCs_Mouse0.74785990
99* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74779404
100* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.74205033
101FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.74183489
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.71175083
103MAF_26560356_Chip-Seq_TH1_Human0.70580934
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69050197
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.68276975
106RUNX1_22412390_ChIP-Seq_EML_Mouse0.67105377
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.67081179
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.66471749
109NANOG_21062744_ChIP-ChIP_HESCs_Human0.65691474
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.65446122
111NANOG_18555785_ChIP-Seq_MESCs_Mouse0.65423855
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.65176708
113UTX_26944678_Chip-Seq_JUKART_Human0.64866548
114VDR_22108803_ChIP-Seq_LS180_Human0.64657406
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.63271619
116TCF7_22412390_ChIP-Seq_EML_Mouse0.62941120
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.61958966
118* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.61605857
119NCOR1_26117541_ChIP-Seq_K562_Human0.61544183
120RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.61523880
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.60344853
122* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.60332628
123SALL4_22934838_ChIP-ChIP_CD34+_Human0.60224565
124GATA6_25053715_ChIP-Seq_YYC3_Human0.58492445
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.58225772
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.58146450
127* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.56413342
128TDRD3_21172665_ChIP-Seq_MCF-7_Human0.56315169
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.55420862
130* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.55238282
131PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.54128625
132SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.53228884
133SALL1_21062744_ChIP-ChIP_HESCs_Human0.53053991
134FUS_26573619_Chip-Seq_HEK293_Human0.52991186
135AR_21572438_ChIP-Seq_LNCaP_Human0.52718260
136KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.52699909
137MYB_26560356_Chip-Seq_TH2_Human0.52179629
138BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.51780812
139MYC_18358816_ChIP-ChIP_MESCs_Mouse0.49411739
140LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.49265658
141VDR_24763502_ChIP-Seq_THP-1_Human0.49016021
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.48516519

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo9.64599489
2MP0004147_increased_porphyrin_level8.92145005
3MP0003111_abnormal_nucleus_morphology4.16737618
4MP0010094_abnormal_chromosome_stability4.04825908
5MP0005083_abnormal_biliary_tract3.59097427
6MP0005645_abnormal_hypothalamus_physiol3.54364146
7MP0003077_abnormal_cell_cycle3.31803367
8MP0010307_abnormal_tumor_latency3.24741235
9MP0003693_abnormal_embryo_hatching2.60899876
10MP0008057_abnormal_DNA_replication2.39646092
11MP0003718_maternal_effect2.33484597
12MP0004957_abnormal_blastocyst_morpholog2.19378295
13MP0001986_abnormal_taste_sensitivity2.17816871
14MP0005076_abnormal_cell_differentiation2.15266266
15MP0009697_abnormal_copulation2.06789433
16MP0010352_gastrointestinal_tract_polyps2.01619329
17MP0002160_abnormal_reproductive_system1.98604327
18MP0003705_abnormal_hypodermis_morpholog1.92604171
19MP0000350_abnormal_cell_proliferation1.90864000
20MP0000569_abnormal_digit_pigmentation1.73779336
21MP0008877_abnormal_DNA_methylation1.70918259
22MP0000372_irregular_coat_pigmentation1.70560937
23MP0005397_hematopoietic_system_phenotyp1.67797910
24MP0001545_abnormal_hematopoietic_system1.67797910
25MP0008058_abnormal_DNA_repair1.66741899
26MP0001661_extended_life_span1.61659837
27MP0002009_preneoplasia1.58091956
28MP0004808_abnormal_hematopoietic_stem1.56972734
29MP0000490_abnormal_crypts_of1.51594381
30MP0006072_abnormal_retinal_apoptosis1.51166344
31MP0002736_abnormal_nociception_after1.51044116
32MP0001730_embryonic_growth_arrest1.50330619
33MP0006035_abnormal_mitochondrial_morpho1.49785462
34MP0002396_abnormal_hematopoietic_system1.46622787
35MP0002163_abnormal_gland_morphology1.46347962
36MP0006292_abnormal_olfactory_placode1.45874230
37MP0006054_spinal_hemorrhage1.44946438
38MP0005171_absent_coat_pigmentation1.43807433
39MP0003300_gastrointestinal_ulcer1.43386807
40MP0005220_abnormal_exocrine_pancreas1.43087904
41MP0008995_early_reproductive_senescence1.42855304
42MP0002019_abnormal_tumor_incidence1.42305212
43MP0002877_abnormal_melanocyte_morpholog1.40762598
44MP0005389_reproductive_system_phenotype1.40248757
45MP0002398_abnormal_bone_marrow1.40090913
46MP0000631_abnormal_neuroendocrine_gland1.39876417
47MP0009046_muscle_twitch1.38464528
48MP0002138_abnormal_hepatobiliary_system1.34907742
49MP0005084_abnormal_gallbladder_morpholo1.34695904
50MP0005646_abnormal_pituitary_gland1.34408081
51MP0002086_abnormal_extraembryonic_tissu1.31090610
52MP0003787_abnormal_imprinting1.26948078
53MP0002102_abnormal_ear_morphology1.26541850
54MP0002928_abnormal_bile_duct1.26266956
55MP0002166_altered_tumor_susceptibility1.26079304
56MP0002722_abnormal_immune_system1.25705148
57MP0002210_abnormal_sex_determination1.25523262
58MP0008932_abnormal_embryonic_tissue1.24896400
59MP0000313_abnormal_cell_death1.22572166
60MP0000015_abnormal_ear_pigmentation1.21139285
61MP0008770_decreased_survivor_rate1.20936238
62MP0001835_abnormal_antigen_presentation1.18090111
63MP0001697_abnormal_embryo_size1.17161278
64MP0005253_abnormal_eye_physiology1.17097768
65MP0000689_abnormal_spleen_morphology1.16196920
66MP0005501_abnormal_skin_physiology1.15630482
67MP0002080_prenatal_lethality1.14160273
68MP0004197_abnormal_fetal_growth/weight/1.13531157
69MP0001672_abnormal_embryogenesis/_devel1.10950733
70MP0005380_embryogenesis_phenotype1.10950733
71MP0005551_abnormal_eye_electrophysiolog1.10693612
72MP0003121_genomic_imprinting1.09585205
73MP0000383_abnormal_hair_follicle1.09479947
74MP0000703_abnormal_thymus_morphology1.08898601
75MP0002938_white_spotting1.07628651
76MP0001764_abnormal_homeostasis1.07502729
77MP0000685_abnormal_immune_system1.06654843
78MP0002638_abnormal_pupillary_reflex1.03559722
79MP0003937_abnormal_limbs/digits/tail_de1.03000890
80MP0001529_abnormal_vocalization1.01792799
81MP0001145_abnormal_male_reproductive1.01584094
82MP0002429_abnormal_blood_cell1.01315018
83MP0001919_abnormal_reproductive_system1.00769135
84MP0008007_abnormal_cellular_replicative0.99455900
85MP0005636_abnormal_mineral_homeostasis0.99415776
86MP0003984_embryonic_growth_retardation0.97935464
87MP0000653_abnormal_sex_gland0.97478349
88MP0002735_abnormal_chemical_nociception0.97436632
89MP0002088_abnormal_embryonic_growth/wei0.96495978
90MP0002876_abnormal_thyroid_physiology0.95806381
91MP0003763_abnormal_thymus_physiology0.95163882
92MP0002084_abnormal_developmental_patter0.95024201
93MP0002006_tumorigenesis0.92426417
94MP0003303_peritoneal_inflammation0.91720997
95MP0003136_yellow_coat_color0.91186476
96MP0000427_abnormal_hair_cycle0.90831770
97MP0006276_abnormal_autonomic_nervous0.90666111
98MP0001119_abnormal_female_reproductive0.90426387
99MP0003698_abnormal_male_reproductive0.89717511
100MP0005410_abnormal_fertilization0.88985253
101MP0005647_abnormal_sex_gland0.87924004
102MP0003123_paternal_imprinting0.86426105
103MP0002085_abnormal_embryonic_tissue0.85323416
104MP0009931_abnormal_skin_appearance0.84686278
105MP0009765_abnormal_xenobiotic_induced0.82292601
106MP0002234_abnormal_pharynx_morphology0.80192733
107MP0005621_abnormal_cell_physiology0.79511783
108MP0004264_abnormal_extraembryonic_tissu0.79182457
109MP0004134_abnormal_chest_morphology0.79036025
110MP0009672_abnormal_birth_weight0.78068808
111MP0009703_decreased_birth_body0.76477394
112MP0003566_abnormal_cell_adhesion0.75984302
113MP0003646_muscle_fatigue0.74761697
114MP0005384_cellular_phenotype0.73876242
115MP0005332_abnormal_amino_acid0.72012863
116MP0010771_integument_phenotype0.71961869
117MP0008775_abnormal_heart_ventricle0.71812867
118MP0002095_abnormal_skin_pigmentation0.70767051
119MP0005174_abnormal_tail_pigmentation0.70343803
120MP0001191_abnormal_skin_condition0.67835231
121MP0000371_diluted_coat_color0.67016816
122MP0003699_abnormal_female_reproductive0.66374410
123MP0010234_abnormal_vibrissa_follicle0.66098943
124MP0003786_premature_aging0.64712436
125MP0000716_abnormal_immune_system0.64404506
126MP0001849_ear_inflammation0.63727345
127MP0001293_anophthalmia0.63658994
128MP0005075_abnormal_melanosome_morpholog0.63518723
129MP0008875_abnormal_xenobiotic_pharmacok0.61872320
130MP0003950_abnormal_plasma_membrane0.61646312
131MP0003186_abnormal_redox_activity0.61507923
132MP0001968_abnormal_touch/_nociception0.60558568
133MP0003806_abnormal_nucleotide_metabolis0.60048903
134MP0003448_altered_tumor_morphology0.58326062
135MP0009053_abnormal_anal_canal0.58280608
136MP0000266_abnormal_heart_morphology0.56989286
137MP0002139_abnormal_hepatobiliary_system0.56940939
138MP0004947_skin_inflammation0.56392460
139MP0009278_abnormal_bone_marrow0.52302730
140MP0009764_decreased_sensitivity_to0.51210952
141MP0002925_abnormal_cardiovascular_devel0.51046917
142MP0009763_increased_sensitivity_to0.50604243
143MP0003567_abnormal_fetal_cardiomyocyte0.50431376
144MP0000733_abnormal_muscle_development0.49812140
145MP0005464_abnormal_platelet_physiology0.49345757
146MP0005671_abnormal_response_to0.48500412
147MP0008260_abnormal_autophagy0.48390058
148MP0008872_abnormal_physiological_respon0.48377511
149MP0001915_intracranial_hemorrhage0.47580845
150MP0001784_abnormal_fluid_regulation0.47094827
151MP0000598_abnormal_liver_morphology0.45611491
152MP0000358_abnormal_cell_content/0.45109963
153MP0001800_abnormal_humoral_immune0.44624826
154MP0002111_abnormal_tail_morphology0.43064769
155MP0004185_abnormal_adipocyte_glucose0.42733245
156MP0001243_abnormal_dermal_layer0.42679702
157MP0001929_abnormal_gametogenesis0.42352961
158MP0002092_abnormal_eye_morphology0.42271492

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)9.70881266
2Acanthocytosis (HP:0001927)7.65161750
3Cholelithiasis (HP:0001081)6.86998587
4Reticulocytosis (HP:0001923)6.26451439
5Abnormal gallbladder morphology (HP:0012437)6.16006322
6Diaphragmatic weakness (HP:0009113)5.48978480
7Hypochromic anemia (HP:0001931)4.88736191
8Insomnia (HP:0100785)4.80260779
9Abnormality of reticulocytes (HP:0004312)4.63463450
10Abnormality of the gallbladder (HP:0005264)4.17718691
11Hyperbilirubinemia (HP:0002904)4.09493119
12Paralysis (HP:0003470)3.97133880
13Osteomalacia (HP:0002749)3.96388980
14Microcytic anemia (HP:0001935)3.90557361
15Cutaneous photosensitivity (HP:0000992)3.87662300
16Abnormal gallbladder physiology (HP:0012438)3.67261011
17Cholecystitis (HP:0001082)3.67261011
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.20818035
19Abnormality of alanine metabolism (HP:0010916)3.20818035
20Hyperalaninemia (HP:0003348)3.20818035
21IgA deficiency (HP:0002720)3.17955521
22Birth length less than 3rd percentile (HP:0003561)3.14443782
23Hypoplasia of the pons (HP:0012110)3.07414274
24Chromsome breakage (HP:0040012)2.96494183
25Abnormality of the pons (HP:0007361)2.95726270
26Clubbing of toes (HP:0100760)2.93044873
27Volvulus (HP:0002580)2.88407745
28Abnormality of DNA repair (HP:0003254)2.85611554
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82151472
30High pitched voice (HP:0001620)2.79430977
31Impulsivity (HP:0100710)2.73210450
32Abnormality of the fingertips (HP:0001211)2.67944716
33IgM deficiency (HP:0002850)2.64116520
34Abnormality of chromosome stability (HP:0003220)2.63655388
35Pancreatic cysts (HP:0001737)2.60580630
36Cerebellar dysplasia (HP:0007033)2.54187422
37Type II lissencephaly (HP:0007260)2.53861790
38Hyponatremia (HP:0002902)2.51936786
39Hepatocellular carcinoma (HP:0001402)2.48881698
40Basal cell carcinoma (HP:0002671)2.43560417
41Global brain atrophy (HP:0002283)2.41768671
42Absent thumb (HP:0009777)2.38243324
43Abnormality of the renal collecting system (HP:0004742)2.37487368
44Duplicated collecting system (HP:0000081)2.35941070
45Prominent nose (HP:0000448)2.35792624
46Ileus (HP:0002595)2.34899294
47Increased CSF lactate (HP:0002490)2.34300580
48Increased serum lactate (HP:0002151)2.33811378
49Abnormality of sodium homeostasis (HP:0010931)2.33726356
50Cafe-au-lait spot (HP:0000957)2.28077400
51Hepatocellular necrosis (HP:0001404)2.26375481
52Papilledema (HP:0001085)2.25274977
53Urticaria (HP:0001025)2.25046972
54Short thumb (HP:0009778)2.23621178
55Abnormality of the renal cortex (HP:0011035)2.17024245
56Abnormal auditory evoked potentials (HP:0006958)2.16731518
57Renal cortical cysts (HP:0000803)2.16020361
58Pustule (HP:0200039)2.15633524
59Mitochondrial inheritance (HP:0001427)2.15246262
60Cortical dysplasia (HP:0002539)2.12635870
61Pancreatic fibrosis (HP:0100732)2.11508583
623-Methylglutaconic aciduria (HP:0003535)2.10296400
63Hepatic necrosis (HP:0002605)2.07960029
64Duodenal stenosis (HP:0100867)2.07395971
65Small intestinal stenosis (HP:0012848)2.07395971
66Attenuation of retinal blood vessels (HP:0007843)2.06459274
67Abnormal mitochondria in muscle tissue (HP:0008316)2.05969633
68Acute encephalopathy (HP:0006846)2.05006946
69Chronic hepatic failure (HP:0100626)2.04886281
70True hermaphroditism (HP:0010459)2.03724072
71Petechiae (HP:0000967)2.03679776
72Confusion (HP:0001289)2.03653571
73Heterotopia (HP:0002282)2.03144521
74Lissencephaly (HP:0001339)2.03046776
75Acute necrotizing encephalopathy (HP:0006965)2.00097955
76Poikilocytosis (HP:0004447)13.5519187
77Hypochromic microcytic anemia (HP:0004840)10.4753655
78Bone marrow hypocellularity (HP:0005528)1.97088466
79Lipid accumulation in hepatocytes (HP:0006561)1.96898440
80Abnormality of midbrain morphology (HP:0002418)1.96187520
81Molar tooth sign on MRI (HP:0002419)1.96187520
82Abnormality of the labia minora (HP:0012880)1.95056208
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93684793
84Prostate neoplasm (HP:0100787)1.93267372
85Aplasia/Hypoplasia of the uvula (HP:0010293)1.92186459
86Short middle phalanx of the 5th finger (HP:0004220)1.91958866
87Verrucae (HP:0200043)1.91239754
88Papilloma (HP:0012740)1.91239754
89Recurrent sinusitis (HP:0011108)1.89254213
90Squamous cell carcinoma (HP:0002860)1.89017975
91Congenital stationary night blindness (HP:0007642)1.87792062
92Hypoplastic iliac wings (HP:0002866)1.87087302
93Thyroiditis (HP:0100646)1.86892940
94IgG deficiency (HP:0004315)1.85560774
95Generalized hyperpigmentation (HP:0007440)1.85146999
96Increased nuchal translucency (HP:0010880)1.83209573
97Meckel diverticulum (HP:0002245)1.82469686
98Abnormality of B cell number (HP:0010975)1.81821699
99Glioma (HP:0009733)1.80911980
100Colon cancer (HP:0003003)1.79203672
101Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78924004
102Macrocytic anemia (HP:0001972)1.78155621
103Pendular nystagmus (HP:0012043)1.77731399
104Lactic acidosis (HP:0003128)1.77465098
105Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77035721
106Pancytopenia (HP:0001876)1.76848513
107Astrocytoma (HP:0009592)1.76773641
108Abnormality of the astrocytes (HP:0100707)1.76773641
109Delusions (HP:0000746)1.75733568
110Medulloblastoma (HP:0002885)1.75027738
111Abnormality of homocysteine metabolism (HP:0010919)1.74919995
112Homocystinuria (HP:0002156)1.74919995
113Triphalangeal thumb (HP:0001199)1.74449067
114Abnormality of chromosome segregation (HP:0002916)1.74174363
115Reticulocytopenia (HP:0001896)1.73707024
116Abnormality of the preputium (HP:0100587)1.73148590
117Childhood onset (HP:0011463)1.72111626
118Dyschromatopsia (HP:0007641)1.71845439
119Abnormality of the ileum (HP:0001549)1.71455970
120Cutaneous melanoma (HP:0012056)1.70352455
121Oligohydramnios (HP:0001562)1.68080837
122Horseshoe kidney (HP:0000085)1.67311462
123Truncal obesity (HP:0001956)1.66672297
124Abnormality of the prostate (HP:0008775)1.66162696
125Sclerocornea (HP:0000647)1.65971842
126Tinnitus (HP:0000360)1.65524648
127Cerebral edema (HP:0002181)1.64725893
128Arteriovenous malformation (HP:0100026)1.64194201
129Sandal gap (HP:0001852)1.64193952
130Ependymoma (HP:0002888)1.63509616
131Long eyelashes (HP:0000527)1.63458509
132Lower limb hyperreflexia (HP:0002395)1.63250009
133Pathologic fracture (HP:0002756)1.62861517
134Aplasia/Hypoplasia of the tibia (HP:0005772)1.62284296
135Progressive macrocephaly (HP:0004481)1.61279860
136Microtia (HP:0008551)1.61068181
137Partial agenesis of the corpus callosum (HP:0001338)1.60476475
138Abnormality of the duodenum (HP:0002246)1.60399494
139Concave nail (HP:0001598)1.59993847
140Myelodysplasia (HP:0002863)1.59881649
141Short 4th metacarpal (HP:0010044)1.59415757
142Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.59415757
143Oral leukoplakia (HP:0002745)1.59083934
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.58596408
145Patellar aplasia (HP:0006443)1.58500339
146Acute lymphatic leukemia (HP:0006721)1.58134003
147Sloping forehead (HP:0000340)1.57854169
148Hemorrhage of the eye (HP:0011885)1.56652657
149B lymphocytopenia (HP:0010976)1.56449866
150Abnormality of T cell physiology (HP:0011840)1.56297853
151Panhypogammaglobulinemia (HP:0003139)1.56252464
152Selective tooth agenesis (HP:0001592)1.55830877
153Colitis (HP:0002583)1.55673452
154Increased mean platelet volume (HP:0011877)1.53514604
155Abnormality of cells of the erythroid lineage (HP:0012130)1.52603060
156Ulnar bowing (HP:0003031)1.52307557
157Abnormal platelet volume (HP:0011876)1.52196197
158Proximal placement of thumb (HP:0009623)1.49011673
159Agnosia (HP:0010524)1.48772673
160Macroorchidism (HP:0000053)1.48615208
161Deep philtrum (HP:0002002)1.47327587
162Ectopic kidney (HP:0000086)1.45966014
163Deviation of the thumb (HP:0009603)1.45731280
164Long clavicles (HP:0000890)1.44457345
165Rhabdomyosarcoma (HP:0002859)1.43822068
166Entropion (HP:0000621)1.42742487
167Aplasia/Hypoplasia of the patella (HP:0006498)1.42138644
168Abnormal number of erythroid precursors (HP:0012131)1.41258566
169Prolonged bleeding time (HP:0003010)1.37447570
170Neoplasm of the liver (HP:0002896)1.36294172
171Abnormality of the carotid arteries (HP:0005344)1.35684527
172Freckling (HP:0001480)1.35514970
173Cellulitis (HP:0100658)1.34170252

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.31415484
2ZAK6.34362807
3STK44.70969270
4CDK123.84348218
5VRK13.53571016
6CDC73.31051760
7RPS6KA53.03170147
8EIF2AK12.30707291
9MAP3K82.03615915
10AURKB1.85111711
11NEK21.85059630
12PIM11.83604647
13CDK91.62514071
14FRK1.59860451
15BRD41.55822462
16SCYL21.53320714
17GRK61.42155665
18DYRK31.35200780
19WEE11.33751219
20CHEK21.33515355
21CAMK1D1.33212579
22EEF2K1.33115652
23BMPR1B1.30010606
24NUAK11.18769706
25STK101.18759896
26MAP3K101.15541439
27PKN11.14242251
28TTK1.13675128
29MST41.11901726
30CDK61.08425715
31AURKA1.04024524
32NEK11.03844134
33MAP4K21.02181604
34PLK10.98041450
35BCKDK0.96160852
36ADRBK20.94153189
37TRPM70.91194434
38CDK40.91055345
39TAOK30.86852844
40PBK0.84439973
41BRSK10.83761606
42ACVR1B0.83279387
43DYRK1B0.78493120
44GRK10.75213686
45NME20.74295534
46ATR0.74175942
47PIM20.74100369
48TAF10.74078420
49CHEK10.71353349
50BUB10.69438237
51RPS6KB20.69300329
52CDK80.68503195
53MAP3K40.67962181
54BTK0.67869841
55EIF2AK30.67488916
56PLK30.67382930
57MELK0.65346296
58STK30.64595543
59SGK10.63947063
60TEC0.63648877
61ATM0.59553192
62WNK40.59038966
63MAP2K70.58588824
64BRSK20.58020339
65SRPK10.57054875
66CAMK1G0.56886503
67PKN20.56197968
68* PRKAA10.55439765
69CDK20.53695276
70MAPKAPK30.53052862
71TTN0.52292868
72CSNK1G30.51817456
73IKBKB0.51788432
74PIK3CG0.51679500
75ERBB20.49950814
76CDK10.49375438
77AKT20.48973401
78INSRR0.48080641
79CAMKK20.46944039
80CSNK1A1L0.46452502
81BLK0.45987063
82CDK70.45184587
83CSNK1G10.44032410
84AKT30.43101705
85DAPK30.43037057
86MAPK130.41382169
87JAK20.40754289
88CSNK1D0.40696056
89MAPK110.40657038
90PRKCI0.38524881
91BMPR20.35822917
92SGK30.33773279
93SYK0.33254681
94MKNK20.32497281
95STK390.32037870
96STK160.31749968
97PRKCQ0.31679744
98FGR0.31503594
99RPS6KA30.31236990
100CSNK1G20.31218601
101WNK30.31217953
102EIF2AK20.30264345
103FLT30.27372692
104CAMK40.26889392
105MAPK140.26513540
106MUSK0.25784135
107AKT10.24556388
108VRK20.23284057
109TSSK60.23041988
110DYRK1A0.22855009
111CDK150.20984460
112ADRBK10.20951145
113PASK0.20899993
114LRRK20.20818792
115MTOR0.20794970
116PRKDC0.20726792
117DYRK20.20489857
118PRKCB0.19645961
119PDK20.19159574
120CCNB10.17462535
121GRK50.17371547
122PAK10.17071322
123OXSR10.16979524
124BMX0.16970226
125RAF10.16814517
126CDK180.16456785
127MARK30.16317920
128BRAF0.16156209
129DAPK20.15754494
130CDK11A0.14232910
131CSF1R0.13742019
132MAP4K10.13532121
133MAP2K60.13094583
134MAP2K10.12602519
135ROCK10.10876831
136GSK3B0.10560324
137LYN0.10162028
138PRKAA20.09641532
139SGK20.09638386
140MAPKAPK50.08653725
141PLK40.08332547
142HIPK20.08296183
143MAPK10.08147806
144CDK140.08147378
145EGFR0.06536910
146TGFBR20.06032780
147CLK10.05968101
148CHUK0.05912988

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.80307263
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008604.05106380
3* Viral carcinogenesis_Homo sapiens_hsa052033.32303741
4DNA replication_Homo sapiens_hsa030302.37282221
5Cell cycle_Homo sapiens_hsa041102.15905377
6* Systemic lupus erythematosus_Homo sapiens_hsa0532211.9429969
7Mismatch repair_Homo sapiens_hsa034301.75157657
8Intestinal immune network for IgA production_Homo sapiens_hsa046721.54855128
9Transcriptional misregulation in cancer_Homo sapiens_hsa052021.50423285
10Fanconi anemia pathway_Homo sapiens_hsa034601.36044684
11One carbon pool by folate_Homo sapiens_hsa006701.23674898
12Asthma_Homo sapiens_hsa053101.23048395
13Malaria_Homo sapiens_hsa051441.23021222
14Primary immunodeficiency_Homo sapiens_hsa053401.20584898
15Nucleotide excision repair_Homo sapiens_hsa034201.18646729
16Base excision repair_Homo sapiens_hsa034101.17714444
17RNA polymerase_Homo sapiens_hsa030201.14156672
18Homologous recombination_Homo sapiens_hsa034401.13116516
19Basal transcription factors_Homo sapiens_hsa030221.08568582
20p53 signaling pathway_Homo sapiens_hsa041151.05257804
21Non-homologous end-joining_Homo sapiens_hsa034501.03067067
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93732351
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89433134
24Hematopoietic cell lineage_Homo sapiens_hsa046400.88733965
25Dorso-ventral axis formation_Homo sapiens_hsa043200.86374601
26RNA transport_Homo sapiens_hsa030130.83602034
27Nitrogen metabolism_Homo sapiens_hsa009100.83550084
28Non-small cell lung cancer_Homo sapiens_hsa052230.82698264
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82257261
30Oocyte meiosis_Homo sapiens_hsa041140.79709015
31Small cell lung cancer_Homo sapiens_hsa052220.76627755
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76569627
33Oxidative phosphorylation_Homo sapiens_hsa001900.76489009
34Allograft rejection_Homo sapiens_hsa053300.74060636
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73790354
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69143967
37Chronic myeloid leukemia_Homo sapiens_hsa052200.68754412
38Autoimmune thyroid disease_Homo sapiens_hsa053200.67924278
39Maturity onset diabetes of the young_Homo sapiens_hsa049500.67437195
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66212079
41MicroRNAs in cancer_Homo sapiens_hsa052060.66031453
42Bladder cancer_Homo sapiens_hsa052190.65732625
43Graft-versus-host disease_Homo sapiens_hsa053320.63617745
44Parkinsons disease_Homo sapiens_hsa050120.62719223
45Spliceosome_Homo sapiens_hsa030400.61041370
46Herpes simplex infection_Homo sapiens_hsa051680.60719920
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60050979
48mRNA surveillance pathway_Homo sapiens_hsa030150.59841422
49ABC transporters_Homo sapiens_hsa020100.59235312
50Sulfur relay system_Homo sapiens_hsa041220.58680078
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58670825
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57695976
53Sulfur metabolism_Homo sapiens_hsa009200.57400749
54Butanoate metabolism_Homo sapiens_hsa006500.57105965
55Apoptosis_Homo sapiens_hsa042100.55343350
56Vitamin B6 metabolism_Homo sapiens_hsa007500.53931413
57Selenocompound metabolism_Homo sapiens_hsa004500.53410742
58Type I diabetes mellitus_Homo sapiens_hsa049400.52709160
59Huntingtons disease_Homo sapiens_hsa050160.52384546
60Pancreatic cancer_Homo sapiens_hsa052120.49837153
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48961580
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47228984
63HTLV-I infection_Homo sapiens_hsa051660.46719386
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45813387
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45626249
66Hepatitis B_Homo sapiens_hsa051610.45470217
67Glioma_Homo sapiens_hsa052140.44533179
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44095262
69Prostate cancer_Homo sapiens_hsa052150.43993210
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43494513
71Phototransduction_Homo sapiens_hsa047440.42979290
72Antigen processing and presentation_Homo sapiens_hsa046120.40174382
73Lysine degradation_Homo sapiens_hsa003100.40097298
74FoxO signaling pathway_Homo sapiens_hsa040680.39081844
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38494904
76Pyrimidine metabolism_Homo sapiens_hsa002400.37926782
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37177120
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36446158
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34856348
80Folate biosynthesis_Homo sapiens_hsa007900.34430456
81Proteasome_Homo sapiens_hsa030500.34406968
82Tryptophan metabolism_Homo sapiens_hsa003800.33553561
83Olfactory transduction_Homo sapiens_hsa047400.33248214
84Measles_Homo sapiens_hsa051620.32527784
85Epstein-Barr virus infection_Homo sapiens_hsa051690.32486760
86AMPK signaling pathway_Homo sapiens_hsa041520.26915443
87Linoleic acid metabolism_Homo sapiens_hsa005910.25978958
88N-Glycan biosynthesis_Homo sapiens_hsa005100.25766037
89Alzheimers disease_Homo sapiens_hsa050100.25551467
90Propanoate metabolism_Homo sapiens_hsa006400.25497186
91Metabolic pathways_Homo sapiens_hsa011000.23488430
92Taste transduction_Homo sapiens_hsa047420.22587213
93Ribosome_Homo sapiens_hsa030100.22020697
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.21737335
95mTOR signaling pathway_Homo sapiens_hsa041500.20995146
96Melanoma_Homo sapiens_hsa052180.20014070
97Steroid biosynthesis_Homo sapiens_hsa001000.19550266
98Pyruvate metabolism_Homo sapiens_hsa006200.19061410
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18510493
100Peroxisome_Homo sapiens_hsa041460.18369809
101RNA degradation_Homo sapiens_hsa030180.17784465
102B cell receptor signaling pathway_Homo sapiens_hsa046620.16668917
103Basal cell carcinoma_Homo sapiens_hsa052170.16642712
104Influenza A_Homo sapiens_hsa051640.16328269
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.16295342
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15360423
107Glutathione metabolism_Homo sapiens_hsa004800.15170524
108Endometrial cancer_Homo sapiens_hsa052130.14714079
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12958226
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12303496
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.12187869
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12064484
113Platelet activation_Homo sapiens_hsa046110.11906928
114Regulation of autophagy_Homo sapiens_hsa041400.11565248
115TGF-beta signaling pathway_Homo sapiens_hsa043500.11330154
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11173324
117Thyroid cancer_Homo sapiens_hsa052160.10068075
118Proteoglycans in cancer_Homo sapiens_hsa052050.10058902
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.09943762
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.07719151
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.07474643
122Collecting duct acid secretion_Homo sapiens_hsa049660.07222815
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.06998450
124Colorectal cancer_Homo sapiens_hsa052100.06911207
125Hepatitis C_Homo sapiens_hsa051600.06902105
126Ether lipid metabolism_Homo sapiens_hsa005650.06730774
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.06680389
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.06218900
129Caffeine metabolism_Homo sapiens_hsa002320.06034950
130Leishmaniasis_Homo sapiens_hsa051400.05930385
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.05366204
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.05296383
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.04407308
134Pathways in cancer_Homo sapiens_hsa052000.04282899
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.03913205
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.03831190
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.03593033
138Notch signaling pathway_Homo sapiens_hsa043300.02796195
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.02710963
140Hedgehog signaling pathway_Homo sapiens_hsa043400.01915769
141Nicotine addiction_Homo sapiens_hsa050330.01833296
142Type II diabetes mellitus_Homo sapiens_hsa049300.01611647
143Toxoplasmosis_Homo sapiens_hsa051450.01397437
144Chemokine signaling pathway_Homo sapiens_hsa040620.01317815
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.01277042
146ECM-receptor interaction_Homo sapiens_hsa045120.00515935
147Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0311589
148Biosynthesis of amino acids_Homo sapiens_hsa01230-0.0281597
149Focal adhesion_Homo sapiens_hsa04510-0.0201983
150Regulation of actin cytoskeleton_Homo sapiens_hsa04810-0.0141212
151Purine metabolism_Homo sapiens_hsa00230-0.0138126
152Osteoclast differentiation_Homo sapiens_hsa04380-0.0094805
153PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0085152
154HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0053244

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