HIST1H2BG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)8.61815031
2DNA replication-dependent nucleosome organization (GO:0034723)8.61815031
3chromatin assembly (GO:0031497)7.73479596
4nucleosome assembly (GO:0006334)7.04802105
5regulation of histone H3-K9 methylation (GO:0051570)6.63778009
6nucleosome organization (GO:0034728)6.09074204
7protein-DNA complex assembly (GO:0065004)5.94125694
8antibacterial humoral response (GO:0019731)5.87291527
9chromatin assembly or disassembly (GO:0006333)5.68640357
10innate immune response in mucosa (GO:0002227)5.65675751
11nuclear pore complex assembly (GO:0051292)5.58035767
12antimicrobial humoral response (GO:0019730)5.55818397
13DNA unwinding involved in DNA replication (GO:0006268)5.52229065
14nuclear pore organization (GO:0006999)5.49366350
15hematopoietic stem cell differentiation (GO:0060218)5.45977617
16mitotic chromosome condensation (GO:0007076)5.36165108
17negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)5.35162677
18protein localization to kinetochore (GO:0034501)5.34055297
19protein-DNA complex subunit organization (GO:0071824)5.31179012
20sister chromatid segregation (GO:0000819)5.05468538
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.94228056
22protoporphyrinogen IX metabolic process (GO:0046501)4.87301427
23regulation of megakaryocyte differentiation (GO:0045652)4.63923094
24protein localization to chromosome, centromeric region (GO:0071459)4.63480043
25mitotic sister chromatid segregation (GO:0000070)4.59306837
26protoporphyrinogen IX biosynthetic process (GO:0006782)4.33903486
27mucosal immune response (GO:0002385)4.32558667
28pore complex assembly (GO:0046931)4.25965397
29DNA replication initiation (GO:0006270)4.23563278
30CENP-A containing nucleosome assembly (GO:0034080)4.20030303
31chromatin remodeling at centromere (GO:0031055)4.18769760
32folic acid-containing compound biosynthetic process (GO:0009396)4.13087251
33organ or tissue specific immune response (GO:0002251)4.08484589
34positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.08184480
35positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.08184480
36positive regulation of mitotic sister chromatid separation (GO:1901970)4.08184480
37regulation of DNA endoreduplication (GO:0032875)4.04005477
38regulation of gene silencing (GO:0060968)3.97335124
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.94973940
40kinetochore organization (GO:0051383)3.94955851
41regulation of centriole replication (GO:0046599)3.92458037
42DNA strand elongation involved in DNA replication (GO:0006271)3.91075205
43negative regulation of histone methylation (GO:0031061)3.90398506
44positive regulation of chromosome segregation (GO:0051984)3.90205237
45DNA duplex unwinding (GO:0032508)3.90084021
46regulation of hematopoietic progenitor cell differentiation (GO:1901532)3.89788977
47dosage compensation (GO:0007549)3.89664784
48DNA geometric change (GO:0032392)3.89546683
49mitotic nuclear envelope disassembly (GO:0007077)3.89181598
50protein K6-linked ubiquitination (GO:0085020)3.85545690
51DNA replication-independent nucleosome assembly (GO:0006336)3.84414213
52DNA replication-independent nucleosome organization (GO:0034724)3.84414213
53mitotic sister chromatid cohesion (GO:0007064)3.82653483
54meiotic chromosome segregation (GO:0045132)3.76289312
55DNA strand elongation (GO:0022616)3.73023669
56telomere maintenance via semi-conservative replication (GO:0032201)3.72948267
57mitotic recombination (GO:0006312)3.72413700
58erythrocyte maturation (GO:0043249)3.69992847
59nuclear envelope disassembly (GO:0051081)3.69406081
60membrane disassembly (GO:0030397)3.69406081
61defense response to Gram-positive bacterium (GO:0050830)3.66564963
62regulation of sister chromatid cohesion (GO:0007063)3.62817463
63negative regulation of B cell apoptotic process (GO:0002903)3.61769308
64IMP biosynthetic process (GO:0006188)3.59067540
65attachment of spindle microtubules to kinetochore (GO:0008608)3.57188942
66DNA topological change (GO:0006265)3.55662746
67chromosome condensation (GO:0030261)3.55438488
68translesion synthesis (GO:0019985)3.52561566
69microtubule depolymerization (GO:0007019)3.51170476
70regulation of centrosome cycle (GO:0046605)3.50655532
71DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.46150267
72telomere maintenance via recombination (GO:0000722)3.43993317
73histone exchange (GO:0043486)3.38439426
74regulation of centrosome duplication (GO:0010824)3.29782259
75regulation of spindle organization (GO:0090224)3.27798515
76DNA conformation change (GO:0071103)3.27756791
77regulation of translational fidelity (GO:0006450)3.25774224
78positive regulation of histone methylation (GO:0031062)3.25088332
79protein localization to chromosome (GO:0034502)3.24658633
80growth hormone receptor signaling pathway (GO:0060396)3.23883389
81IMP metabolic process (GO:0046040)3.23329726
82postreplication repair (GO:0006301)3.23171321
83mitotic metaphase plate congression (GO:0007080)3.21271010
84mRNA cleavage (GO:0006379)3.20870310
85somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17670523
86somatic hypermutation of immunoglobulin genes (GO:0016446)3.17670523
87metaphase plate congression (GO:0051310)3.17396097
88regulation of chromosome segregation (GO:0051983)3.17295170
89chromosome segregation (GO:0007059)3.16096011
90telomere maintenance (GO:0000723)3.13777373
91regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.13035078
92DNA synthesis involved in DNA repair (GO:0000731)3.11872329
93porphyrin-containing compound biosynthetic process (GO:0006779)3.10454059
94telomere organization (GO:0032200)3.09734533
95regulation of mitotic metaphase/anaphase transition (GO:0030071)3.08274603
96nucleotide-excision repair, DNA gap filling (GO:0006297)3.08155731
97rRNA transcription (GO:0009303)3.07077027
98positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.06820351
99DNA packaging (GO:0006323)3.06566314
100DNA damage response, signal transduction resulting in transcription (GO:0042772)3.05422071
101regulation of mitotic spindle organization (GO:0060236)3.05154062
102DNA replication checkpoint (GO:0000076)3.02586338
103ATP-dependent chromatin remodeling (GO:0043044)3.01372655
104establishment of chromosome localization (GO:0051303)3.00631040
105regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99739938
106spindle checkpoint (GO:0031577)2.99732791
107negative regulation of DNA-dependent DNA replication (GO:2000104)2.98602949
108mitotic DNA integrity checkpoint (GO:0044774)2.97618491
109positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.96437111
110ribosomal small subunit assembly (GO:0000028)2.95800928
111regulation of RNA export from nucleus (GO:0046831)2.94910655
112mitochondrial DNA replication (GO:0006264)2.92317779
113spindle assembly checkpoint (GO:0071173)2.91269624
114cellular response to growth hormone stimulus (GO:0071378)2.89263134
115regulation of sister chromatid segregation (GO:0033045)2.89218765
116regulation of mitotic sister chromatid segregation (GO:0033047)2.89218765
117replicative senescence (GO:0090399)2.87259354
118positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.83497525
119positive regulation of prostaglandin secretion (GO:0032308)2.79018221
120synapsis (GO:0007129)2.78923030
121replication fork processing (GO:0031297)2.77629700
122viral mRNA export from host cell nucleus (GO:0046784)2.62506618
123tRNA methylation (GO:0030488)2.61800665
124maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61163825
125transcription elongation from RNA polymerase I promoter (GO:0006362)2.60940756
126cell fate commitment involved in formation of primary germ layer (GO:0060795)2.59605080
127RNA destabilization (GO:0050779)2.59573421
128detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.57967636
129response to growth hormone (GO:0060416)2.57879582
130positive regulation of erythrocyte differentiation (GO:0045648)2.57703528
131definitive hemopoiesis (GO:0060216)2.56959113
132regulation of B cell apoptotic process (GO:0002902)2.55673697
133termination of RNA polymerase I transcription (GO:0006363)2.55673418
134histone demethylation (GO:0016577)2.54687375
135tryptophan metabolic process (GO:0006568)2.54644637
136sister chromatid cohesion (GO:0007062)2.50225603
137regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.47925614
138histone H3-K9 methylation (GO:0051567)2.46402007
139reciprocal meiotic recombination (GO:0007131)2.46263069
140reciprocal DNA recombination (GO:0035825)2.46263069
141negative regulation of DNA recombination (GO:0045910)2.44780331
142immunoglobulin mediated immune response (GO:0016064)2.43364039
143DNA deamination (GO:0045006)2.42400063
144pseudouridine synthesis (GO:0001522)2.40418064
145detection of light stimulus involved in visual perception (GO:0050908)2.39776640
146detection of light stimulus involved in sensory perception (GO:0050962)2.39776640
147mitochondrial DNA metabolic process (GO:0032042)2.38644394
148histone lysine demethylation (GO:0070076)2.34886004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.01928048
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.77729714
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.32855652
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.56166100
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.54385618
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.85380476
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68830152
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40244042
9* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.26722065
10IRF1_19129219_ChIP-ChIP_H3396_Human2.23253924
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.19619795
12* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15150086
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse15.0229824
14* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.99106884
15NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93482792
16MYC_18555785_ChIP-Seq_MESCs_Mouse1.88798505
17EGR1_19374776_ChIP-ChIP_THP-1_Human1.87917604
18* SOX2_16153702_ChIP-ChIP_HESCs_Human1.85982661
19CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.79183111
20TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.71950611
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68675390
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.56862226
23AR_21909140_ChIP-Seq_LNCAP_Human1.54619747
24ZNF274_21170338_ChIP-Seq_K562_Hela1.54063177
25* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.49445602
26* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46877548
27* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46692960
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43286563
29SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42466770
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40418068
31* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39814541
32* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37760535
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37603816
34* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37346069
35* VDR_23849224_ChIP-Seq_CD4+_Human1.35148601
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33523761
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32393473
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31162206
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30705144
40* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29162330
41* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29034657
42MYC_18940864_ChIP-ChIP_HL60_Human1.26953025
43MYC_22102868_ChIP-Seq_BL_Human1.23995582
44ELK1_19687146_ChIP-ChIP_HELA_Human1.22300057
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21851702
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18750456
47* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13080998
48GATA1_22025678_ChIP-Seq_K562_Human1.12519501
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12374887
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09660086
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06928633
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06324229
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04658227
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02420405
55* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01608480
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.01044917
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00991389
58* NANOG_16153702_ChIP-ChIP_HESCs_Human1.00805972
59EWS_26573619_Chip-Seq_HEK293_Human0.99631080
60E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99085804
61TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99001695
62PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98863933
63* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98267971
64NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97059592
65SALL4_22934838_ChIP-ChIP_CD34+_Human0.96502789
66FOXP3_21729870_ChIP-Seq_TREG_Human0.95885620
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94439715
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93428855
69GABP_17652178_ChIP-ChIP_JURKAT_Human0.92439012
70XRN2_22483619_ChIP-Seq_HELA_Human0.91753466
71VDR_21846776_ChIP-Seq_THP-1_Human0.91301327
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90521861
73TP63_19390658_ChIP-ChIP_HaCaT_Human0.89857419
74FUS_26573619_Chip-Seq_HEK293_Human0.89756174
75THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89427122
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89122953
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88180954
78MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85393826
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84399612
80KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.84025543
81TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83460565
82* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.81380070
83RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81028794
84CREB1_15753290_ChIP-ChIP_HEK293T_Human0.80831318
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80201645
86IRF8_22096565_ChIP-ChIP_GC-B_Human0.80079052
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80059235
88ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79863985
89GATA1_19941826_ChIP-Seq_K562_Human0.78522410
90CIITA_25753668_ChIP-Seq_RAJI_Human0.77274693
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.76963480
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74835609
93* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.74496418
94* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.74027493
95SCL_19346495_ChIP-Seq_HPC-7_Human0.73791684
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.73760162
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.73244261
98EST1_17652178_ChIP-ChIP_JURKAT_Human0.73145103
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.72818595
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.72628269
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.71828456
102* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.70806911
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70359370
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.69645016
105IGF1R_20145208_ChIP-Seq_DFB_Human0.69450481
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.69398714
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.68960793
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.65681809
109KDM5A_27292631_Chip-Seq_BREAST_Human0.65277372
110MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.64773963
111TFEB_21752829_ChIP-Seq_HELA_Human0.63940736
112* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.63810497
113MAF_26560356_Chip-Seq_TH1_Human0.63560524
114UTX_26944678_Chip-Seq_JUKART_Human0.62386371
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.62318688
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.62250711
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.62172169
118TTF2_22483619_ChIP-Seq_HELA_Human0.61018156
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.59600926
120TCF7_22412390_ChIP-Seq_EML_Mouse0.59486876
121ETS1_20019798_ChIP-Seq_JURKAT_Human0.58972032
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.58155368
123* SOX9_26525672_Chip-Seq_HEART_Mouse0.54227111
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.53127320
125ER_23166858_ChIP-Seq_MCF-7_Human0.50895792
126IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.50472240
127FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.49286256
128YY1_21170310_ChIP-Seq_MESCs_Mouse0.48170000
129VDR_22108803_ChIP-Seq_LS180_Human0.47533104
130JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.47265663
131DCP1A_22483619_ChIP-Seq_HELA_Human0.46262219
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.45246022
133FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.45086547
134SRF_21415370_ChIP-Seq_HL-1_Mouse0.42504755
135TP53_22573176_ChIP-Seq_HFKS_Human0.42230690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system5.00560554
2MP0010094_abnormal_chromosome_stability4.89099745
3MP0003111_abnormal_nucleus_morphology4.20702085
4MP0000013_abnormal_adipose_tissue4.19226690
5MP0010307_abnormal_tumor_latency3.90111957
6MP0003077_abnormal_cell_cycle3.70883026
7MP0003656_abnormal_erythrocyte_physiolo3.43872701
8MP0003693_abnormal_embryo_hatching3.43236613
9MP0010352_gastrointestinal_tract_polyps3.19503487
10MP0004147_increased_porphyrin_level3.11929556
11MP0008057_abnormal_DNA_replication3.08526962
12MP0004957_abnormal_blastocyst_morpholog2.97920689
13MP0008004_abnormal_stomach_pH2.59821091
14MP0008058_abnormal_DNA_repair2.43900607
15MP0003705_abnormal_hypodermis_morpholog2.38583401
16MP0008007_abnormal_cellular_replicative2.37166452
17MP0005076_abnormal_cell_differentiation2.26589088
18MP0000350_abnormal_cell_proliferation2.22298021
19MP0002396_abnormal_hematopoietic_system2.20380080
20MP0010234_abnormal_vibrissa_follicle2.12584486
21MP0004808_abnormal_hematopoietic_stem2.11273657
22MP0006054_spinal_hemorrhage2.11072612
23MP0002877_abnormal_melanocyte_morpholog2.09326686
24MP0004381_abnormal_hair_follicle2.05111207
25MP0000003_abnormal_adipose_tissue1.99256610
26MP0005645_abnormal_hypothalamus_physiol1.96662384
27MP0001730_embryonic_growth_arrest1.96097282
28MP0008932_abnormal_embryonic_tissue1.89910508
29MP0006072_abnormal_retinal_apoptosis1.88502201
30MP0003718_maternal_effect1.85544961
31MP0000490_abnormal_crypts_of1.81947279
32MP0008877_abnormal_DNA_methylation1.74512137
33MP0004197_abnormal_fetal_growth/weight/1.67506313
34MP0002638_abnormal_pupillary_reflex1.66715841
35MP0002166_altered_tumor_susceptibility1.66511150
36MP0003123_paternal_imprinting1.65613147
37MP0003121_genomic_imprinting1.65073408
38MP0002086_abnormal_extraembryonic_tissu1.61538168
39MP0002019_abnormal_tumor_incidence1.55940368
40MP0001697_abnormal_embryo_size1.55427412
41MP0005220_abnormal_exocrine_pancreas1.52851299
42MP0009697_abnormal_copulation1.51869835
43MP0001661_extended_life_span1.50904268
44MP0002009_preneoplasia1.48836990
45MP0001672_abnormal_embryogenesis/_devel1.48681827
46MP0005380_embryogenesis_phenotype1.48681827
47MP0002080_prenatal_lethality1.47169197
48MP0002084_abnormal_developmental_patter1.44807067
49MP0005167_abnormal_blood-brain_barrier1.44076038
50MP0002398_abnormal_bone_marrow1.38910008
51MP0001929_abnormal_gametogenesis1.38130202
52MP0005253_abnormal_eye_physiology1.37410989
53MP0002160_abnormal_reproductive_system1.37183221
54MP0002085_abnormal_embryonic_tissue1.36713904
55MP0000703_abnormal_thymus_morphology1.36633394
56MP0003786_premature_aging1.36483029
57MP0002095_abnormal_skin_pigmentation1.35617777
58MP0002006_tumorigenesis1.34642128
59MP0005646_abnormal_pituitary_gland1.34552501
60MP0001545_abnormal_hematopoietic_system1.33262650
61MP0005397_hematopoietic_system_phenotyp1.33262650
62MP0000313_abnormal_cell_death1.33016839
63MP0002722_abnormal_immune_system1.30583254
64MP0003984_embryonic_growth_retardation1.29685781
65MP0005187_abnormal_penis_morphology1.28368373
66MP0002210_abnormal_sex_determination1.28294888
67MP0002088_abnormal_embryonic_growth/wei1.28000854
68MP0006292_abnormal_olfactory_placode1.25719890
69MP0001502_abnormal_circadian_rhythm1.24727895
70MP0001293_anophthalmia1.24089583
71MP0002928_abnormal_bile_duct1.21253940
72MP0000689_abnormal_spleen_morphology1.20006322
73MP0003136_yellow_coat_color1.17816938
74MP0001145_abnormal_male_reproductive1.16768393
75MP0008995_early_reproductive_senescence1.15484888
76MP0003787_abnormal_imprinting1.13657106
77MP0005075_abnormal_melanosome_morpholog1.13358046
78MP0000653_abnormal_sex_gland1.13018920
79MP0003300_gastrointestinal_ulcer1.11443071
80MP0000647_abnormal_sebaceous_gland1.10544374
81MP0005389_reproductive_system_phenotype1.04122875
82MP0002092_abnormal_eye_morphology1.02949317
83MP0003567_abnormal_fetal_cardiomyocyte1.02777220
84MP0006276_abnormal_autonomic_nervous1.01137581
85MP0008770_decreased_survivor_rate1.00761487
86MP0002429_abnormal_blood_cell0.99932790
87MP0003937_abnormal_limbs/digits/tail_de0.99362468
88MP0003698_abnormal_male_reproductive0.99070242
89MP0003566_abnormal_cell_adhesion0.97993450
90MP0000733_abnormal_muscle_development0.97818434
91MP0000631_abnormal_neuroendocrine_gland0.97405858
92MP0001915_intracranial_hemorrhage0.96067232
93MP0002282_abnormal_trachea_morphology0.95954604
94MP0003890_abnormal_embryonic-extraembry0.95059726
95MP0000613_abnormal_salivary_gland0.94603704
96MP0000372_irregular_coat_pigmentation0.92593765
97MP0000371_diluted_coat_color0.91127239
98MP0009703_decreased_birth_body0.90402979
99MP0005083_abnormal_biliary_tract0.90199983
100MP0000537_abnormal_urethra_morphology0.90151093
101MP0001919_abnormal_reproductive_system0.90044041
102MP0005410_abnormal_fertilization0.89828698
103MP0005621_abnormal_cell_physiology0.87615730
104MP0000685_abnormal_immune_system0.87184732
105MP0002697_abnormal_eye_size0.86878551
106MP0002075_abnormal_coat/hair_pigmentati0.86093700
107MP0003950_abnormal_plasma_membrane0.85789903
108MP0000358_abnormal_cell_content/0.85685351
109MP0001764_abnormal_homeostasis0.84095155
110MP0001800_abnormal_humoral_immune0.83729656
111MP0005384_cellular_phenotype0.83161030
112MP0005391_vision/eye_phenotype0.82709736
113MP0000716_abnormal_immune_system0.80916758
114MP0005501_abnormal_skin_physiology0.80823840
115MP0002111_abnormal_tail_morphology0.80699473
116MP0005623_abnormal_meninges_morphology0.80249363
117MP0006035_abnormal_mitochondrial_morpho0.79831685
118MP0005647_abnormal_sex_gland0.79144798
119MP0005023_abnormal_wound_healing0.77590970
120MP0000383_abnormal_hair_follicle0.77555407
121MP0005171_absent_coat_pigmentation0.77279080
122MP0008875_abnormal_xenobiotic_pharmacok0.76511409
123MP0003763_abnormal_thymus_physiology0.75641663
124MP0005551_abnormal_eye_electrophysiolog0.75435701
125MP0004233_abnormal_muscle_weight0.75402185
126MP0002736_abnormal_nociception_after0.75297702
127MP0001119_abnormal_female_reproductive0.75276998
128MP0009053_abnormal_anal_canal0.74899815
129MP0009672_abnormal_birth_weight0.74857057
130MP0008872_abnormal_physiological_respon0.74600636
131MP0001849_ear_inflammation0.73714986
132MP0002925_abnormal_cardiovascular_devel0.73669305
133MP0000569_abnormal_digit_pigmentation0.72972532
134MP0010678_abnormal_skin_adnexa0.71680679
135MP0001984_abnormal_olfaction0.70038090
136MP0009278_abnormal_bone_marrow0.69739906
137MP0000470_abnormal_stomach_morphology0.68866566
138MP0002452_abnormal_antigen_presenting0.68458846
139MP0003448_altered_tumor_morphology0.67759418
140MP0003699_abnormal_female_reproductive0.67661485
141MP0003315_abnormal_perineum_morphology0.66561292
142MP0005360_urolithiasis0.65927052
143MP0002420_abnormal_adaptive_immunity0.64433950
144MP0004947_skin_inflammation0.64411907
145MP0001186_pigmentation_phenotype0.64304882
146MP0000477_abnormal_intestine_morphology0.63835291
147MP0003453_abnormal_keratinocyte_physiol0.63731457
148MP0008438_abnormal_cutaneous_collagen0.63594439
149MP0004264_abnormal_extraembryonic_tissu0.62869633
150MP0001819_abnormal_immune_cell0.62486688
151MP0001835_abnormal_antigen_presentation0.61996939
152MP0003303_peritoneal_inflammation0.60781897
153MP0001286_abnormal_eye_development0.60527433
154MP0009931_abnormal_skin_appearance0.58789804
155MP0001191_abnormal_skin_condition0.58110475

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)5.76644097
2Hypochromic microcytic anemia (HP:0004840)5.14247375
3Abnormality of the heme biosynthetic pathway (HP:0010472)4.39075372
4Chromsome breakage (HP:0040012)4.20018799
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.00364091
6Cutaneous melanoma (HP:0012056)3.87125661
7Abnormality of chromosome stability (HP:0003220)3.57198892
8Acanthocytosis (HP:0001927)3.51691226
9Cerebellar dysplasia (HP:0007033)3.48126346
10Reticulocytopenia (HP:0001896)3.45142353
11Abnormality of the proximal phalanges of the hand (HP:0009834)3.35818178
12Volvulus (HP:0002580)3.23169913
13Generalized hypopigmentation of hair (HP:0011358)3.12914537
14Abnormality of reticulocytes (HP:0004312)3.09594181
15Abnormality of the renal cortex (HP:0011035)3.06398579
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.06169717
17Abnormality of alanine metabolism (HP:0010916)3.06169717
18Hyperalaninemia (HP:0003348)3.06169717
19Type II lissencephaly (HP:0007260)3.05659839
20Birth length less than 3rd percentile (HP:0003561)3.00396954
21Panhypogammaglobulinemia (HP:0003139)2.93157240
22Reticulocytosis (HP:0001923)2.89598334
23Short 4th metacarpal (HP:0010044)2.88339979
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.88339979
25Renal cortical cysts (HP:0000803)2.86855840
26Dry hair (HP:0011359)2.85281824
27Ependymoma (HP:0002888)2.84679742
28Impulsivity (HP:0100710)2.82054839
29Large eyes (HP:0001090)2.78124936
30Medulloblastoma (HP:0002885)2.76935622
31IgA deficiency (HP:0002720)2.74411385
32Colon cancer (HP:0003003)2.72498052
33Abnormality of the pons (HP:0007361)2.69545409
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.67407076
35Basal cell carcinoma (HP:0002671)2.65685210
36Astrocytoma (HP:0009592)2.65334571
37Abnormality of the astrocytes (HP:0100707)2.65334571
38Colitis (HP:0002583)2.62818076
39Hypochromic anemia (HP:0001931)2.62368988
40Fair hair (HP:0002286)2.60772143
41Cafe-au-lait spot (HP:0000957)2.58698601
42Hypoplasia of the pons (HP:0012110)2.58630837
43High pitched voice (HP:0001620)2.58334333
44Selective tooth agenesis (HP:0001592)2.56780837
45Agnosia (HP:0010524)2.55063677
46Myelodysplasia (HP:0002863)2.51837821
47Rhabdomyosarcoma (HP:0002859)2.50801908
48Small intestinal stenosis (HP:0012848)2.49435355
49Duodenal stenosis (HP:0100867)2.49435355
50Prominent nose (HP:0000448)2.48197298
51Meckel diverticulum (HP:0002245)2.46349374
52Abnormality of B cell number (HP:0010975)2.45639157
53Abnormality of the fingertips (HP:0001211)2.42434988
54Chronic hepatic failure (HP:0100626)2.42351881
55Squamous cell carcinoma (HP:0002860)2.40746698
56Cortical dysplasia (HP:0002539)2.39413204
57Increased nuchal translucency (HP:0010880)2.37820165
58Abnormality of the labia minora (HP:0012880)2.37101860
59Abnormality of the preputium (HP:0100587)2.36760046
60Abnormality of the ileum (HP:0001549)2.35341976
61Hypopigmentation of the fundus (HP:0007894)2.33958803
62Abnormality of cells of the erythroid lineage (HP:0012130)2.33788541
63Carpal bone hypoplasia (HP:0001498)2.30715708
64Neoplasm of the oral cavity (HP:0100649)2.27126824
65Sandal gap (HP:0001852)2.25580824
66Glioma (HP:0009733)2.25456591
67Freckling (HP:0001480)2.24968484
68Absent frontal sinuses (HP:0002688)2.24436238
69Oral leukoplakia (HP:0002745)2.21977792
70Deviation of the thumb (HP:0009603)2.21357806
7111 pairs of ribs (HP:0000878)2.21037726
72Sloping forehead (HP:0000340)2.20251552
73Ectopic kidney (HP:0000086)2.17354937
74Cholelithiasis (HP:0001081)2.17313324
75Agammaglobulinemia (HP:0004432)2.15050534
76Insomnia (HP:0100785)2.14945297
77Proximal placement of thumb (HP:0009623)2.14135115
78Chronic sinusitis (HP:0011109)2.13231532
79Abnormality of the renal collecting system (HP:0004742)2.12695651
80Heterotopia (HP:0002282)2.12485097
81Chronic otitis media (HP:0000389)2.11223264
82Patellar aplasia (HP:0006443)2.09065355
83B lymphocytopenia (HP:0010976)2.07694077
84Abnormality of the carotid arteries (HP:0005344)2.07071856
85Acute lymphatic leukemia (HP:0006721)2.05580814
86Thyroiditis (HP:0100646)2.05213455
87Villous atrophy (HP:0011473)2.03849326
88Abnormality of small intestinal villus morphology (HP:0011472)2.03849326
89Abnormality of the duodenum (HP:0002246)2.03736286
90Partial agenesis of the corpus callosum (HP:0001338)2.02809559
91Thrombocytosis (HP:0001894)2.02656688
92Abnormal number of erythroid precursors (HP:0012131)2.02146970
93Subacute progressive viral hepatitis (HP:0006572)2.01768938
94Biliary tract neoplasm (HP:0100574)2.01080945
95Absent thumb (HP:0009777)2.00907617
96Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99118161
97Ulnar bowing (HP:0003031)1.98620293
98Amaurosis fugax (HP:0100576)1.98164357
99Pancreatic cysts (HP:0001737)1.95596439
100Abnormality of the 4th metacarpal (HP:0010012)1.94039599
101Prostate neoplasm (HP:0100787)1.92918342
102Entropion (HP:0000621)1.92497222
103Gastrointestinal carcinoma (HP:0002672)1.91489883
104Malignant gastrointestinal tract tumors (HP:0006749)1.91489883
105Anterior segment dysgenesis (HP:0007700)1.89862459
106Abnormality of the phalanges of the 2nd finger (HP:0009541)1.89571571
107Verrucae (HP:0200043)1.89527692
108Papilloma (HP:0012740)1.89527692
109Bone marrow hypocellularity (HP:0005528)1.89147903
110Aplasia/Hypoplasia of the patella (HP:0006498)1.89133126
111Missing ribs (HP:0000921)1.88831112
112Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.87715078
113Pallor (HP:0000980)1.87305358
1143-Methylglutaconic aciduria (HP:0003535)1.87037509
115Macrocytic anemia (HP:0001972)1.85873954
116Vertebral fusion (HP:0002948)1.85507274
117Spastic diplegia (HP:0001264)1.84912166
118Fibular aplasia (HP:0002990)1.84253106
119Poikiloderma (HP:0001029)1.83150311
120Autoimmune hemolytic anemia (HP:0001890)1.82997773
121Neoplasm of striated muscle (HP:0009728)1.82589178
122Abnormality of the calcaneus (HP:0008364)1.82187520
123Truncal obesity (HP:0001956)1.81493962
124Long eyelashes (HP:0000527)1.80547155
125Abnormal gallbladder morphology (HP:0012437)1.80537036
126Woolly hair (HP:0002224)1.79834439
127Ankle contracture (HP:0006466)1.79775193
128Cutaneous photosensitivity (HP:0000992)1.79712863
129Clubbing of toes (HP:0100760)1.79679007
130Gaze-evoked nystagmus (HP:0000640)1.79378685
131Lymphoma (HP:0002665)1.78257629
132Cutis marmorata (HP:0000965)1.78138527
133Attenuation of retinal blood vessels (HP:0007843)1.77908993
134Viral hepatitis (HP:0006562)1.77361851
135Duplicated collecting system (HP:0000081)1.77071342
136Abnormality of the phalanges of the 5th finger (HP:0004213)1.76975647
137Abnormal number of incisors (HP:0011064)1.76667953
138Aplasia/Hypoplasia of the sternum (HP:0006714)1.75919376
139Abnormality of transition element cation homeostasis (HP:0011030)1.75395142
140Flat capital femoral epiphysis (HP:0003370)1.74848729
141Elevated erythrocyte sedimentation rate (HP:0003565)1.74629235
142Atresia of the external auditory canal (HP:0000413)1.74408947
143Neoplasm of the pancreas (HP:0002894)1.74292710
144Optic nerve hypoplasia (HP:0000609)1.73807537
145Abnormality of T cell physiology (HP:0011840)1.70897521
146IgM deficiency (HP:0002850)1.70264615
147Hematochezia (HP:0002573)1.69911931
148Abnormality of the renal medulla (HP:0100957)1.69727339
149Abnormality of chromosome segregation (HP:0002916)1.69698842
150Recurrent bronchitis (HP:0002837)1.69361187
151Acute myeloid leukemia (HP:0004808)1.68857031
152Pancreatic fibrosis (HP:0100732)1.68804920
153Abnormal lung lobation (HP:0002101)1.68170107
154Embryonal renal neoplasm (HP:0011794)1.67760906
155Short thumb (HP:0009778)1.67470880
156Nephroblastoma (Wilms tumor) (HP:0002667)1.67237969
157Cellulitis (HP:0100658)1.67231362
158Abnormal albumin level (HP:0012116)1.66150955
159Hypoalbuminemia (HP:0003073)1.66150955
160Recurrent sinusitis (HP:0011108)1.64601295
161Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63258941
162Facial asymmetry (HP:0000324)1.62968375
163Congenital, generalized hypertrichosis (HP:0004540)1.61925275
164Supernumerary spleens (HP:0009799)1.61250509
165Flat occiput (HP:0005469)1.60204381

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.44001271
2ZAK6.31666596
3VRK13.62526410
4CDC73.42537122
5STK43.33949713
6RPS6KA52.73306835
7BMPR1B2.54045500
8NEK22.03163705
9EEF2K2.01516320
10CDK121.99553871
11SCYL21.98600474
12WEE11.94323065
13CDK91.85399942
14AURKB1.76807245
15MAP3K101.73769074
16PIM11.71338512
17MAP3K81.69760053
18CHEK21.50083804
19PKN21.44561670
20SRPK11.36023117
21RPS6KB21.33497895
22EIF2AK11.31596812
23BUB11.27640938
24DYRK31.25991959
25CDK81.24740663
26CASK1.14449166
27FLT31.13271461
28TTK1.12544304
29ATR1.11389056
30NEK11.10429669
31DAPK31.06744706
32PLK11.06130566
33BRD41.00677928
34TTN1.00295337
35MST40.99633428
36PKN10.96294056
37EPHA20.94822919
38GRK60.94147584
39PASK0.90360460
40STK100.90102278
41AURKA0.88887670
42ACVR1B0.88465028
43CDK40.88292743
44NME20.87966281
45CAMK1D0.83268449
46WNK40.83030713
47BCKDK0.79311444
48BRSK20.78036898
49CHEK10.77160763
50PLK30.76421874
51CDK60.76228620
52MELK0.71370510
53DYRK1B0.70737770
54ATM0.69290132
55PLK20.65478452
56FRK0.64461741
57CDK70.62339183
58NUAK10.60555387
59STK30.59579162
60PRKAA10.59505155
61CDK20.58549805
62PBK0.54901139
63AKT20.54786717
64GRK10.54365996
65TGFBR10.53191779
66PRKCI0.53144245
67ADRBK20.52723935
68TAF10.51903958
69MKNK20.50778161
70MAP3K40.50756118
71CDK10.45726693
72LRRK20.45180762
73MAPKAPK50.43578592
74SYK0.43063583
75BRSK10.42565958
76TEC0.41435424
77BTK0.39999273
78TRPM70.39580548
79TIE10.38703010
80CSNK1D0.36502310
81EIF2AK20.35279539
82RPS6KA40.34276397
83EIF2AK30.33512250
84PLK40.32975651
85FGFR20.31467521
86TSSK60.31357397
87CSNK1G30.30814663
88DYRK20.30665093
89CSF1R0.30276982
90MARK30.30263958
91TRIB30.29570602
92LATS10.29507622
93JAK20.29345639
94MAP2K70.29184303
95MTOR0.29106713
96CSNK1G10.28650694
97CCNB10.28262609
98PRKDC0.26950592
99TAOK30.26762151
100PIK3CG0.25492833
101EPHA30.25272589
102PAK10.25217892
103PINK10.24961739
104BLK0.24571300
105BMX0.24049462
106RPS6KB10.23958001
107MKNK10.23955100
108KIT0.23953894
109MET0.22681384
110PAK40.22173671
111MAPK140.22154380
112AKT10.21485140
113MAPK150.20664616
114NEK60.20492285
115CSNK1A1L0.20400641
116ALK0.20389143
117MAP2K20.20263825
118MAP4K10.19967109
119CHUK0.18132177
120KDR0.17816859
121NEK90.17717558
122SMG10.17486610
123CAMK40.17403208
124PRKCQ0.17200018
125STK160.16793801
126PIM20.16478670
127CLK10.16448316
128MAPKAPK30.16123757
129MAPK110.15896555
130ROCK10.15689863
131MAP2K10.15475565
132IRAK10.15231246
133KSR10.15229275
134FGR0.15165241
135RPS6KA10.14846675
136CSNK2A20.14533840
137SGK10.14442546
138PAK20.14426669
139FGFR30.13925412
140NLK0.13457899
141IKBKB0.13253910
142CDK190.12188983
143PRKCD0.11098711
144PTK60.11063647

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.18349258
2* Viral carcinogenesis_Homo sapiens_hsa052033.29610463
3DNA replication_Homo sapiens_hsa030303.11514482
4Mismatch repair_Homo sapiens_hsa034302.61168630
5Cell cycle_Homo sapiens_hsa041102.13967956
6* Systemic lupus erythematosus_Homo sapiens_hsa0532210.8931100
7One carbon pool by folate_Homo sapiens_hsa006701.98342049
8Transcriptional misregulation in cancer_Homo sapiens_hsa052021.88515510
9Non-homologous end-joining_Homo sapiens_hsa034501.83403016
10Base excision repair_Homo sapiens_hsa034101.71823707
11Nucleotide excision repair_Homo sapiens_hsa034201.65416796
12Fanconi anemia pathway_Homo sapiens_hsa034601.65363698
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60053167
14Homologous recombination_Homo sapiens_hsa034401.60046755
15RNA transport_Homo sapiens_hsa030131.55901289
16Asthma_Homo sapiens_hsa053101.55542884
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51905283
18Spliceosome_Homo sapiens_hsa030401.36254594
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34434531
20Allograft rejection_Homo sapiens_hsa053301.33628419
21Autoimmune thyroid disease_Homo sapiens_hsa053201.27535497
22Graft-versus-host disease_Homo sapiens_hsa053321.25606045
23p53 signaling pathway_Homo sapiens_hsa041151.25278036
24Ribosome_Homo sapiens_hsa030101.23916598
25mRNA surveillance pathway_Homo sapiens_hsa030150.97813449
26Type I diabetes mellitus_Homo sapiens_hsa049400.96847280
27MicroRNAs in cancer_Homo sapiens_hsa052060.96684847
28Small cell lung cancer_Homo sapiens_hsa052220.88929689
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86162388
30Nitrogen metabolism_Homo sapiens_hsa009100.84299172
31Pyrimidine metabolism_Homo sapiens_hsa002400.82800359
32Chronic myeloid leukemia_Homo sapiens_hsa052200.79042177
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75334510
34Herpes simplex infection_Homo sapiens_hsa051680.72026927
35Non-small cell lung cancer_Homo sapiens_hsa052230.71730046
36RNA degradation_Homo sapiens_hsa030180.70264151
37HTLV-I infection_Homo sapiens_hsa051660.67524661
38Antigen processing and presentation_Homo sapiens_hsa046120.65364261
39Selenocompound metabolism_Homo sapiens_hsa004500.64400289
40Oocyte meiosis_Homo sapiens_hsa041140.63286167
41RNA polymerase_Homo sapiens_hsa030200.59822371
42Epstein-Barr virus infection_Homo sapiens_hsa051690.59804573
43Apoptosis_Homo sapiens_hsa042100.59799615
44Staphylococcus aureus infection_Homo sapiens_hsa051500.57116318
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56376891
46Bladder cancer_Homo sapiens_hsa052190.54620611
47Hepatitis B_Homo sapiens_hsa051610.53160766
48Pancreatic cancer_Homo sapiens_hsa052120.50451764
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.49420044
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47981785
51Measles_Homo sapiens_hsa051620.47132082
52Hematopoietic cell lineage_Homo sapiens_hsa046400.46784856
53B cell receptor signaling pathway_Homo sapiens_hsa046620.45430823
54mTOR signaling pathway_Homo sapiens_hsa041500.45050112
55Colorectal cancer_Homo sapiens_hsa052100.43241329
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.42885658
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41406274
58Glioma_Homo sapiens_hsa052140.39323310
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38693466
60Prostate cancer_Homo sapiens_hsa052150.38631004
61Malaria_Homo sapiens_hsa051440.38079110
62FoxO signaling pathway_Homo sapiens_hsa040680.38016328
63Olfactory transduction_Homo sapiens_hsa047400.37385147
64Thyroid cancer_Homo sapiens_hsa052160.36156292
65Basal transcription factors_Homo sapiens_hsa030220.33716959
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33615752
67Lysine degradation_Homo sapiens_hsa003100.33485274
68Melanoma_Homo sapiens_hsa052180.33218310
69Legionellosis_Homo sapiens_hsa051340.32774844
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32390652
71Phototransduction_Homo sapiens_hsa047440.32033035
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30933106
73TGF-beta signaling pathway_Homo sapiens_hsa043500.30615077
74Primary immunodeficiency_Homo sapiens_hsa053400.29779391
75Influenza A_Homo sapiens_hsa051640.28023416
76Proteoglycans in cancer_Homo sapiens_hsa052050.27755011
77Endometrial cancer_Homo sapiens_hsa052130.27166388
78Purine metabolism_Homo sapiens_hsa002300.26830236
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25958327
80Butanoate metabolism_Homo sapiens_hsa006500.25867166
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25087667
82Adherens junction_Homo sapiens_hsa045200.24873584
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24502559
84Biosynthesis of amino acids_Homo sapiens_hsa012300.22421993
85Pathways in cancer_Homo sapiens_hsa052000.22108535
86HIF-1 signaling pathway_Homo sapiens_hsa040660.21969321
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21962054
88Leishmaniasis_Homo sapiens_hsa051400.21738798
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21616250
90Viral myocarditis_Homo sapiens_hsa054160.21421897
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21165559
92Toxoplasmosis_Homo sapiens_hsa051450.20681211
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20109610
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.20072645
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19880191
96Proteasome_Homo sapiens_hsa030500.19638886
97Platelet activation_Homo sapiens_hsa046110.19548733
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.19372347
99Taste transduction_Homo sapiens_hsa047420.19368548
100Rheumatoid arthritis_Homo sapiens_hsa053230.18831670
101Renin-angiotensin system_Homo sapiens_hsa046140.18443393
102Sulfur relay system_Homo sapiens_hsa041220.18439043
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17823587
104Acute myeloid leukemia_Homo sapiens_hsa052210.17153633
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17004759
106Notch signaling pathway_Homo sapiens_hsa043300.16696965
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16143237
108Caffeine metabolism_Homo sapiens_hsa002320.16082096
109Focal adhesion_Homo sapiens_hsa045100.15811596
110Hippo signaling pathway_Homo sapiens_hsa043900.15800110
111Pentose phosphate pathway_Homo sapiens_hsa000300.15728117
112AMPK signaling pathway_Homo sapiens_hsa041520.15437732
113Osteoclast differentiation_Homo sapiens_hsa043800.14027957
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.13481967
115Tryptophan metabolism_Homo sapiens_hsa003800.12940555
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12458532
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12242672
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.12229489
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.11675245
120TNF signaling pathway_Homo sapiens_hsa046680.11588767
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11240062
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.10922149
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10835108
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.09667935
125Inositol phosphate metabolism_Homo sapiens_hsa005620.09341357
126Type II diabetes mellitus_Homo sapiens_hsa049300.08179960
127ABC transporters_Homo sapiens_hsa020100.07987211
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.07640022
129Dorso-ventral axis formation_Homo sapiens_hsa043200.07150840
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.04460702
131Huntingtons disease_Homo sapiens_hsa050160.04380312
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.04230958
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.04102454
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.03973056
135Tuberculosis_Homo sapiens_hsa051520.03550210
136Basal cell carcinoma_Homo sapiens_hsa052170.02867831
137Prolactin signaling pathway_Homo sapiens_hsa049170.01209161
138Linoleic acid metabolism_Homo sapiens_hsa005910.00903563
139Serotonergic synapse_Homo sapiens_hsa047260.00651158
140Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400-0.0027333

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