HIST1H2BD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mucosal immune response (GO:0002385)9.16566446
2antibacterial humoral response (GO:0019731)8.82984225
3DNA replication-dependent nucleosome assembly (GO:0006335)8.77999498
4DNA replication-dependent nucleosome organization (GO:0034723)8.77999498
5organ or tissue specific immune response (GO:0002251)8.30467174
6nuclear pore complex assembly (GO:0051292)8.20297106
7antimicrobial humoral response (GO:0019730)8.04088293
8nucleosome assembly (GO:0006334)7.84661291
9chromatin assembly (GO:0031497)7.41778026
10nuclear pore organization (GO:0006999)7.38857025
11protein-DNA complex assembly (GO:0065004)6.70942609
12nucleosome organization (GO:0034728)6.68188825
13pore complex assembly (GO:0046931)6.27914383
14regulation of histone H3-K9 methylation (GO:0051570)5.88963851
15protein-DNA complex subunit organization (GO:0071824)5.88402637
16DNA unwinding involved in DNA replication (GO:0006268)5.53524323
17chromatin assembly or disassembly (GO:0006333)5.51495634
18DNA strand elongation involved in DNA replication (GO:0006271)5.03645794
19DNA strand elongation (GO:0022616)4.86293694
20DNA replication initiation (GO:0006270)4.82425318
21mitotic chromosome condensation (GO:0007076)4.69388541
22protein localization to chromosome, centromeric region (GO:0071459)4.62628710
23telomere maintenance via semi-conservative replication (GO:0032201)4.36539904
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.32160638
25mitotic sister chromatid segregation (GO:0000070)4.28623205
26sister chromatid segregation (GO:0000819)4.27211759
27regulation of sister chromatid cohesion (GO:0007063)4.21485375
28DNA duplex unwinding (GO:0032508)4.13994555
29CENP-A containing nucleosome assembly (GO:0034080)4.04157617
30DNA geometric change (GO:0032392)4.01073806
31telomere maintenance via recombination (GO:0000722)3.98656039
32chromatin remodeling at centromere (GO:0031055)3.93558633
33mitotic sister chromatid cohesion (GO:0007064)3.90679398
34mitotic recombination (GO:0006312)3.85908810
35mitotic nuclear envelope disassembly (GO:0007077)3.84191840
36negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.81209641
37regulation of centrosome cycle (GO:0046605)3.72492166
38double-strand break repair via nonhomologous end joining (GO:0006303)3.71842941
39non-recombinational repair (GO:0000726)3.71842941
40regulation of translational fidelity (GO:0006450)3.70023436
41DNA synthesis involved in DNA repair (GO:0000731)3.65184870
42membrane disassembly (GO:0030397)3.55271853
43nuclear envelope disassembly (GO:0051081)3.55271853
44protein localization to kinetochore (GO:0034501)3.54748012
45defense response to Gram-positive bacterium (GO:0050830)3.52155294
46regulation of centriole replication (GO:0046599)3.48007811
47viral mRNA export from host cell nucleus (GO:0046784)3.47324531
48positive regulation of chromosome segregation (GO:0051984)3.47004446
49regulation of centrosome duplication (GO:0010824)3.45752894
50regulation of chromosome segregation (GO:0051983)3.45727827
51regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.44464724
52DNA conformation change (GO:0071103)3.42048917
53DNA replication checkpoint (GO:0000076)3.39695691
54V(D)J recombination (GO:0033151)3.32858528
55positive regulation of mitotic sister chromatid separation (GO:1901970)3.23606238
56positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.23606238
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.23606238
58positive regulation of cell cycle checkpoint (GO:1901978)3.16511734
59meiotic chromosome segregation (GO:0045132)3.16003966
60telomere maintenance (GO:0000723)3.14986630
61telomere organization (GO:0032200)3.14753448
62kinetochore organization (GO:0051383)3.13780189
63negative regulation of chromosome segregation (GO:0051985)3.12829243
64negative regulation of DNA repair (GO:0045738)3.11425432
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.10660360
66regulation of spindle checkpoint (GO:0090231)3.10418979
67regulation of megakaryocyte differentiation (GO:0045652)3.08736642
68DNA replication-independent nucleosome assembly (GO:0006336)3.08733406
69DNA replication-independent nucleosome organization (GO:0034724)3.08733406
70peptidyl-lysine dimethylation (GO:0018027)3.07994346
71mitochondrial DNA metabolic process (GO:0032042)3.07651839
72regulation of sister chromatid segregation (GO:0033045)3.04914581
73regulation of mitotic sister chromatid separation (GO:0010965)3.04914581
74regulation of mitotic sister chromatid segregation (GO:0033047)3.04914581
75regulation of gene silencing (GO:0060968)3.02703077
76chromosome condensation (GO:0030261)3.01720861
77regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01521128
78regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01521128
79histone exchange (GO:0043486)2.99896645
80ATP-dependent chromatin remodeling (GO:0043044)2.98741630
81spindle checkpoint (GO:0031577)2.98042819
82maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95429523
83DNA topological change (GO:0006265)2.95390985
84protein complex localization (GO:0031503)2.94900976
85mitotic spindle assembly checkpoint (GO:0007094)2.91721455
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91149630
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91149630
88negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91149630
89negative regulation of mitotic sister chromatid separation (GO:2000816)2.91149630
90negative regulation of sister chromatid segregation (GO:0033046)2.91149630
91telomere maintenance via telomere lengthening (GO:0010833)2.90458713
92spindle assembly checkpoint (GO:0071173)2.88250504
93somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87855770
94somatic hypermutation of immunoglobulin genes (GO:0016446)2.87855770
95mitotic spindle checkpoint (GO:0071174)2.87380916
96positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.86681002
97DNA packaging (GO:0006323)2.85946210
98ribosome assembly (GO:0042255)2.84383561
99mitotic metaphase plate congression (GO:0007080)2.84282401
100innate immune response in mucosa (GO:0002227)11.0940874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.96622032
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.61833545
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.02192097
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.00976623
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.69587130
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.85715330
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71562615
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.39583499
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.37362404
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31009832
11SOX2_16153702_ChIP-ChIP_HESCs_Human2.27978685
12MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.25994479
13POU5F1_16153702_ChIP-ChIP_HESCs_Human2.12921704
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse16.2086055
15CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.85930722
16MYC_18555785_ChIP-Seq_MESCs_Mouse1.85450598
17NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78386514
18HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.75831527
19MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68898301
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65110517
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62805992
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56789026
23HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53742358
24ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51647334
25ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50910006
26SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.48403761
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43118607
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42930989
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.37446997
30GATA1_22025678_ChIP-Seq_K562_Human1.31926665
31* AR_21909140_ChIP-Seq_LNCAP_Human1.30670781
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30222158
33* VDR_23849224_ChIP-Seq_CD4+_Human1.27006388
34ELK1_19687146_ChIP-ChIP_HELA_Human1.24764182
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24583743
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19693719
37* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18340582
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17375728
39* NANOG_16153702_ChIP-ChIP_HESCs_Human1.16103561
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14406681
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14157430
42* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13492015
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07281085
44KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07244580
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05605496
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02940751
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01511242
48DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01129972
49XRN2_22483619_ChIP-Seq_HELA_Human1.00521158
50CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99916839
51MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99895185
52ETS1_22383799_ChIP-Seq_G1ME_Mouse0.99770471
53ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99299063
54* IRF1_19129219_ChIP-ChIP_H3396_Human0.99254020
55STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98539030
56PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98028059
57FOXP3_21729870_ChIP-Seq_TREG_Human0.97660228
58ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96878950
59SOX2_18692474_ChIP-Seq_MESCs_Mouse0.96359594
60MYC_18940864_ChIP-ChIP_HL60_Human0.95752826
61DCP1A_22483619_ChIP-Seq_HELA_Human0.95365187
62MYC_22102868_ChIP-Seq_BL_Human0.95100285
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.90947147
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90812958
65CIITA_25753668_ChIP-Seq_RAJI_Human0.90664018
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89210002
67ETS1_20019798_ChIP-Seq_JURKAT_Human0.87981193
68MYCN_18555785_ChIP-Seq_MESCs_Mouse0.87496786
69* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86264519
70PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84025972
71* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.83059809
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82531816
73VDR_21846776_ChIP-Seq_THP-1_Human0.82024216
74KDM5A_27292631_Chip-Seq_BREAST_Human0.80941747
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80158735
76BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80024215
77EST1_17652178_ChIP-ChIP_JURKAT_Human0.79871981
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79067805
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76766646
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.76434487
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.75867388
82NANOG_18555785_ChIP-Seq_MESCs_Mouse0.75754746
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74189045
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.73028365
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.71868385
86ELF1_17652178_ChIP-ChIP_JURKAT_Human0.70746473
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69812170
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69347924
89TTF2_22483619_ChIP-Seq_HELA_Human0.69294003
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.67365213
91* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.66043667
92ZNF263_19887448_ChIP-Seq_K562_Human0.65936599
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.65167491
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.63949662
95TCF3_18692474_ChIP-Seq_MESCs_Mouse0.63764794
96SOX17_20123909_ChIP-Seq_XEN_Mouse0.63497890
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.62560792
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.62192135
99GABP_17652178_ChIP-ChIP_JURKAT_Human0.61322380
100MAF_26560356_Chip-Seq_TH1_Human0.61321597

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.01693864
2MP0010094_abnormal_chromosome_stability4.96622196
3MP0003111_abnormal_nucleus_morphology4.21164504
4MP0003077_abnormal_cell_cycle3.92811412
5MP0003693_abnormal_embryo_hatching3.89052977
6MP0010352_gastrointestinal_tract_polyps3.64583738
7MP0004957_abnormal_blastocyst_morpholog3.56248841
8MP0002009_preneoplasia3.48389156
9MP0010234_abnormal_vibrissa_follicle2.95338412
10MP0008058_abnormal_DNA_repair2.65523531
11MP0008007_abnormal_cellular_replicative2.65254316
12MP0002396_abnormal_hematopoietic_system2.44942493
13MP0008932_abnormal_embryonic_tissue2.44031550
14MP0010307_abnormal_tumor_latency2.39741358
15MP0009697_abnormal_copulation2.35635638
16MP0001661_extended_life_span2.17909214
17MP0000537_abnormal_urethra_morphology2.14927813
18MP0000350_abnormal_cell_proliferation2.00572433
19MP0004808_abnormal_hematopoietic_stem1.94594862
20MP0003786_premature_aging1.92349592
21MP0004185_abnormal_adipocyte_glucose1.88390340
22MP0002166_altered_tumor_susceptibility1.87040853
23MP0003763_abnormal_thymus_physiology1.73122908
24MP0005076_abnormal_cell_differentiation1.72143753
25MP0002877_abnormal_melanocyte_morpholog1.67325562
26MP0001730_embryonic_growth_arrest1.62375051
27MP0002006_tumorigenesis1.50109123
28MP0005380_embryogenesis_phenotype1.47898250
29MP0001672_abnormal_embryogenesis/_devel1.47898250
30MP0000490_abnormal_crypts_of1.46986215
31MP0000313_abnormal_cell_death1.41565277
32MP0002086_abnormal_extraembryonic_tissu1.39963687
33MP0003984_embryonic_growth_retardation1.38522760
34MP0003718_maternal_effect1.36547831
35MP0001697_abnormal_embryo_size1.32912894
36MP0002080_prenatal_lethality1.32316996
37MP0002088_abnormal_embryonic_growth/wei1.32017718
38MP0002019_abnormal_tumor_incidence1.30528911
39MP0002084_abnormal_developmental_patter1.29727521
40MP0003941_abnormal_skin_development1.29529109
41MP0005220_abnormal_exocrine_pancreas1.29370404
42MP0002697_abnormal_eye_size1.26358902
43MP0002163_abnormal_gland_morphology1.19832053
44MP0005083_abnormal_biliary_tract1.17574652
45MP0000358_abnormal_cell_content/1.16943473
46MP0002092_abnormal_eye_morphology1.14252698
47MP0002085_abnormal_embryonic_tissue1.11849879
48MP0006035_abnormal_mitochondrial_morpho1.10963262
49MP0004233_abnormal_muscle_weight1.10836758
50MP0000703_abnormal_thymus_morphology1.09766165
51MP0010678_abnormal_skin_adnexa1.05570124
52MP0003705_abnormal_hypodermis_morpholog1.05019540
53MP0005501_abnormal_skin_physiology1.01351579
54MP0003937_abnormal_limbs/digits/tail_de0.98807358
55MP0002160_abnormal_reproductive_system0.96168213
56MP0004197_abnormal_fetal_growth/weight/0.94097784
57MP0000015_abnormal_ear_pigmentation0.92808646
58MP0002398_abnormal_bone_marrow0.92333779
59MP0002722_abnormal_immune_system0.92167348
60MP0002111_abnormal_tail_morphology0.88009086
61MP0003221_abnormal_cardiomyocyte_apopto0.87066763
62MP0000013_abnormal_adipose_tissue0.86473780
63MP0001915_intracranial_hemorrhage0.86120627
64MP0005384_cellular_phenotype0.85706529
65MP0001293_anophthalmia0.82052571
66MP0003656_abnormal_erythrocyte_physiolo0.81981116
67MP0005187_abnormal_penis_morphology0.81851430
68MP0003315_abnormal_perineum_morphology0.80274387
69MP0001929_abnormal_gametogenesis0.79938140
70MP0005621_abnormal_cell_physiology0.79734137
71MP0003453_abnormal_keratinocyte_physiol0.77694530
72MP0000377_abnormal_hair_follicle0.77117327
73MP0001849_ear_inflammation0.76973468
74MP0000428_abnormal_craniofacial_morphol0.76181304
75MP0001216_abnormal_epidermal_layer0.76107008
76MP0002098_abnormal_vibrissa_morphology0.73623612
77MP0005645_abnormal_hypothalamus_physiol0.73445169
78MP0000689_abnormal_spleen_morphology0.72161503
79MP0002210_abnormal_sex_determination0.71104842
80MP0001286_abnormal_eye_development0.70511331
81MP0000003_abnormal_adipose_tissue0.69669628
82MP0001727_abnormal_embryo_implantation0.66645655
83MP0002060_abnormal_skin_morphology0.66423128
84MP0001145_abnormal_male_reproductive0.66327490
85MP0001191_abnormal_skin_condition0.66238208
86MP0000477_abnormal_intestine_morphology0.65192477
87MP0003890_abnormal_embryonic-extraembry0.63951025
88MP0005391_vision/eye_phenotype0.62617250
89MP0004381_abnormal_hair_follicle0.62291019
90MP0005647_abnormal_sex_gland0.61554722
91MP0003699_abnormal_female_reproductive0.60399409
92MP0003123_paternal_imprinting0.58370114
93MP0009931_abnormal_skin_appearance0.57530175
94MP0002429_abnormal_blood_cell0.57052591
95MP0000733_abnormal_muscle_development0.55884977
96MP0000653_abnormal_sex_gland0.55438760
97MP0009672_abnormal_birth_weight0.54663963
98MP0000627_abnormal_mammary_gland0.54107950
99MP0000383_abnormal_hair_follicle0.53114283
100MP0005451_abnormal_body_composition0.52174604

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.10910277
2Chromsome breakage (HP:0040012)5.52646664
3IgM deficiency (HP:0002850)4.71746516
4IgA deficiency (HP:0002720)4.35638997
5Colitis (HP:0002583)3.84822637
6Abnormality of chromosome stability (HP:0003220)3.72148423
7Abnormality of the preputium (HP:0100587)3.34648226
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.30167669
9Nephroblastoma (Wilms tumor) (HP:0002667)3.14848600
10Medulloblastoma (HP:0002885)3.12567085
11Abnormality of the ileum (HP:0001549)3.06772518
12Reticulocytopenia (HP:0001896)3.03585035
13Meckel diverticulum (HP:0002245)2.94101844
14Embryonal renal neoplasm (HP:0011794)2.92592579
15Abnormality of the carotid arteries (HP:0005344)2.87068107
16Squamous cell carcinoma (HP:0002860)2.76908796
17Birth length less than 3rd percentile (HP:0003561)2.64156615
18Clubbing of toes (HP:0100760)2.63635146
19Thyroiditis (HP:0100646)2.62730215
20Microvesicular hepatic steatosis (HP:0001414)2.58157934
21Myelodysplasia (HP:0002863)2.57311437
22Duodenal stenosis (HP:0100867)2.53079264
23Small intestinal stenosis (HP:0012848)2.53079264
2411 pairs of ribs (HP:0000878)2.51861738
25Sandal gap (HP:0001852)2.36923634
26Cafe-au-lait spot (HP:0000957)2.35520607
27Abnormality of pyrimidine metabolism (HP:0004353)2.34442174
28Astrocytoma (HP:0009592)2.29803132
29Abnormality of the astrocytes (HP:0100707)2.29803132
30Abnormality of DNA repair (HP:0003254)2.28158989
31Abnormality of cells of the erythroid lineage (HP:0012130)2.23589805
32Spastic diplegia (HP:0001264)2.21054857
33Ependymoma (HP:0002888)2.20660461
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20634434
35Subacute progressive viral hepatitis (HP:0006572)2.17056266
36Orthostatic hypotension (HP:0001278)2.14622968
37Short thumb (HP:0009778)2.14520506
38Progressive external ophthalmoplegia (HP:0000590)2.14019760
39Abnormality of the fingertips (HP:0001211)2.13090686
40Renovascular hypertension (HP:0100817)2.12440676
41Prominent nose (HP:0000448)2.11162590
42Deep philtrum (HP:0002002)2.10923060
43Acute lymphatic leukemia (HP:0006721)2.09460077
44Hyperacusis (HP:0010780)2.09416696
45Missing ribs (HP:0000921)2.09386300
46Abnormality of the duodenum (HP:0002246)2.09241515
47Malignant gastrointestinal tract tumors (HP:0006749)2.07736962
48Gastrointestinal carcinoma (HP:0002672)2.07736962
49Sloping forehead (HP:0000340)2.05164650
50Cutaneous melanoma (HP:0012056)2.02130839
51High anterior hairline (HP:0009890)2.01316904
52Basal cell carcinoma (HP:0002671)2.01038986
53Ankyloglossia (HP:0010296)2.00470437
54Papillary thyroid carcinoma (HP:0002895)2.00395107
55Arteriovenous malformation (HP:0100026)2.00093477
56Selective tooth agenesis (HP:0001592)1.99552258
57Cellulitis (HP:0100658)1.98866325
58Hypergonadotropic hypogonadism (HP:0000815)1.98680709
59Leiomyosarcoma (HP:0100243)1.98164315
60Uterine leiomyosarcoma (HP:0002891)1.98164315
61Inflammation of the large intestine (HP:0002037)1.98048803
62Neoplasm of striated muscle (HP:0009728)1.94240372
63Short 4th metacarpal (HP:0010044)1.91987718
64Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91987718
65Embryonal neoplasm (HP:0002898)1.91364957
66Entropion (HP:0000621)1.91137088
67Ectopic kidney (HP:0000086)1.91073044
68Neonatal hypoglycemia (HP:0001998)1.90239198
69Glioma (HP:0009733)1.89449911
70Ureteral duplication (HP:0000073)1.88894555
71Insomnia (HP:0100785)1.88869419
72Duplicated collecting system (HP:0000081)1.87770477
73Rhabdomyosarcoma (HP:0002859)1.86384454
74Asymmetry of the thorax (HP:0001555)1.84956005
75Micronodular cirrhosis (HP:0001413)1.82798989
76Gastrointestinal inflammation (HP:0004386)1.82714996
77Erythema (HP:0010783)1.81366091
78Abnormality of the parietal bone (HP:0002696)1.81290152
79Poikiloderma (HP:0001029)1.80190254
80Acanthocytosis (HP:0001927)1.79659295
81Abnormality of the distal phalanx of the thumb (HP:0009617)1.79363944
82Interstitial pulmonary disease (HP:0006530)1.77893285
83Viral hepatitis (HP:0006562)1.77566641
84Increased nuchal translucency (HP:0010880)1.76167236
85Deep palmar crease (HP:0006191)1.75666853
86Abnormality of chromosome segregation (HP:0002916)1.73657335
87Absent radius (HP:0003974)1.73626246
88Breast carcinoma (HP:0003002)1.72692350
89Lymphoma (HP:0002665)1.72659127
90B lymphocytopenia (HP:0010976)1.71721107
91Acute myeloid leukemia (HP:0004808)1.71685534
92Abnormal foot bone ossification (HP:0010675)1.70808042
93Bladder carcinoma (HP:0002862)1.70743793
94Bladder neoplasm (HP:0009725)1.70743793
95Abnormal number of erythroid precursors (HP:0012131)1.70387854
96Dyschromatopsia (HP:0007641)1.69348967
97Elfin facies (HP:0004428)1.68723274
98Partial agenesis of the corpus callosum (HP:0001338)1.68523860
99Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68409413
100Abnormality of nail color (HP:0100643)1.68200050

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK9.28787893
2TLK18.71040448
3VRK14.84683242
4RPS6KA53.27556831
5DAPK32.34197936
6CDC72.23599168
7SCYL22.01760542
8STK41.97973650
9BUB11.90552727
10AURKA1.80367091
11CHEK21.53305347
12EEF2K1.48564674
13AURKB1.44258497
14SRPK11.39815157
15PBK1.34904705
16TTK1.32630670
17BRSK21.30287078
18SMG11.29749507
19PIM11.26458885
20TRIB31.18495544
21MAP3K101.12179557
22PKN11.11235262
23RPS6KB21.08835853
24NEK11.02924115
25TAF10.98269160
26ICK0.95267989
27NME20.87983110
28EIF2AK30.84246209
29MAP3K80.84195467
30ATR0.82534990
31MAP2K70.81534414
32MAP3K40.79705794
33CDK120.78026316
34TSSK60.77040887
35WEE10.74726148
36BRAF0.74556110
37PLK40.72011971
38PLK10.71411725
39CCNB10.66849031
40CDK70.62119094
41BTK0.59454052
42MST1R0.58462129
43PKN20.57858070
44PRKAA10.56873774
45AKT20.55570423
46CHEK10.55183686
47CAMK1D0.54379388
48MAPK110.52753668
49ATM0.52591478
50CDK60.52200704
51NEK20.51992491
52CDK80.50843152
53MELK0.43984188
54MST40.43901848
55PLK30.43363968
56BRSK10.40841014
57BRD40.39010237
58MAP2K40.37880301
59STK160.37594084
60EIF2AK10.36744005
61PIM20.34006624
62CDK20.33205772
63RAF10.32194845
64CSNK1G10.31724510
65CDK40.31438769
66CAMK1G0.30057447
67CDK10.28811763
68CSNK1A1L0.28401326
69MAP2K30.27977083
70CSNK1G30.26986930
71IRAK30.26424995
72RPS6KB10.26275771
73CAMKK20.23424060
74PAK10.22848017
75EIF2AK20.22808700
76TTN0.22782679
77MKNK20.22686537
78JAK20.20711193
79BLK0.20012091
80RET0.19910231
81PRKCQ0.19761829
82MTOR0.19540749
83ILK0.19467133
84STK30.18880293
85RPS6KA40.18828788
86PRKCI0.18051154
87MAP3K20.17862862
88CAMK40.17303836
89TRPM70.17096616
90MAP2K20.15873937
91IRAK20.14759027
92PIK3CG0.14603898
93NLK0.13843329
94RPS6KA10.12825234
95MET0.12393688
96NEK60.12219982
97NEK90.12064996
98CSNK2A20.11600730
99MAPK140.10495828
100PRKDC0.10041476

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050348.06288158
2* Viral carcinogenesis_Homo sapiens_hsa052033.68247306
3DNA replication_Homo sapiens_hsa030302.87341944
4Mismatch repair_Homo sapiens_hsa034302.07548570
5* Systemic lupus erythematosus_Homo sapiens_hsa0532211.2325996
6Transcriptional misregulation in cancer_Homo sapiens_hsa052021.83076781
7Non-homologous end-joining_Homo sapiens_hsa034501.80526049
8Cell cycle_Homo sapiens_hsa041101.69097013
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63724875
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56112629
11Fanconi anemia pathway_Homo sapiens_hsa034601.39011817
12Nucleotide excision repair_Homo sapiens_hsa034201.38669821
13Homologous recombination_Homo sapiens_hsa034401.35668220
14Base excision repair_Homo sapiens_hsa034101.19357053
15RNA transport_Homo sapiens_hsa030131.04370270
16p53 signaling pathway_Homo sapiens_hsa041150.93838691
17Pyrimidine metabolism_Homo sapiens_hsa002400.86835052
18One carbon pool by folate_Homo sapiens_hsa006700.82170855
19Non-small cell lung cancer_Homo sapiens_hsa052230.77637288
20Spliceosome_Homo sapiens_hsa030400.74195449
21Thyroid cancer_Homo sapiens_hsa052160.67416845
22Chronic myeloid leukemia_Homo sapiens_hsa052200.64019162
23Pancreatic cancer_Homo sapiens_hsa052120.62827764
24Biosynthesis of amino acids_Homo sapiens_hsa012300.62020226
25Sulfur relay system_Homo sapiens_hsa041220.61663460
26Selenocompound metabolism_Homo sapiens_hsa004500.61495875
27Ribosome_Homo sapiens_hsa030100.61003226
28Vitamin B6 metabolism_Homo sapiens_hsa007500.60846437
29RNA polymerase_Homo sapiens_hsa030200.59738073
30Pentose phosphate pathway_Homo sapiens_hsa000300.59401042
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59166850
32B cell receptor signaling pathway_Homo sapiens_hsa046620.52996329
33Colorectal cancer_Homo sapiens_hsa052100.51560365
34mRNA surveillance pathway_Homo sapiens_hsa030150.51071808
35MicroRNAs in cancer_Homo sapiens_hsa052060.50350768
36Glioma_Homo sapiens_hsa052140.50258148
37Small cell lung cancer_Homo sapiens_hsa052220.49616905
38Purine metabolism_Homo sapiens_hsa002300.46858024
39Bladder cancer_Homo sapiens_hsa052190.46323680
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44771812
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43150963
42Central carbon metabolism in cancer_Homo sapiens_hsa052300.42221944
43Epstein-Barr virus infection_Homo sapiens_hsa051690.41598278
44N-Glycan biosynthesis_Homo sapiens_hsa005100.41188635
45Lysine degradation_Homo sapiens_hsa003100.40034179
46Endometrial cancer_Homo sapiens_hsa052130.39224334
47HTLV-I infection_Homo sapiens_hsa051660.38519884
48Inositol phosphate metabolism_Homo sapiens_hsa005620.36553979
49RNA degradation_Homo sapiens_hsa030180.35025565
50Basal transcription factors_Homo sapiens_hsa030220.34393252
51Arginine biosynthesis_Homo sapiens_hsa002200.33583264
52Prostate cancer_Homo sapiens_hsa052150.33050611
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31711296
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31331446
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.30709422
56Apoptosis_Homo sapiens_hsa042100.30656489
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30601407
58Herpes simplex infection_Homo sapiens_hsa051680.30307603
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29581241
60Primary immunodeficiency_Homo sapiens_hsa053400.28611461
61Carbon metabolism_Homo sapiens_hsa012000.28058666
62Hepatitis B_Homo sapiens_hsa051610.26924031
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25127545
64TGF-beta signaling pathway_Homo sapiens_hsa043500.24456742
65Melanoma_Homo sapiens_hsa052180.24361787
66mTOR signaling pathway_Homo sapiens_hsa041500.21837012
67ErbB signaling pathway_Homo sapiens_hsa040120.21703154
68Oocyte meiosis_Homo sapiens_hsa041140.21370334
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21038135
70Acute myeloid leukemia_Homo sapiens_hsa052210.20274998
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20185830
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19947810
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19909602
74Sulfur metabolism_Homo sapiens_hsa009200.19094693
75Basal cell carcinoma_Homo sapiens_hsa052170.18678266
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18571055
77FoxO signaling pathway_Homo sapiens_hsa040680.16700173
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16435875
79Fructose and mannose metabolism_Homo sapiens_hsa000510.14946450
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14635328
81HIF-1 signaling pathway_Homo sapiens_hsa040660.14124445
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13627906
83Hippo signaling pathway_Homo sapiens_hsa043900.13460668
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13435467
85Galactose metabolism_Homo sapiens_hsa000520.13360824
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12015551
87Pyruvate metabolism_Homo sapiens_hsa006200.11138826
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.10747946
89Adherens junction_Homo sapiens_hsa045200.10023421
90Measles_Homo sapiens_hsa051620.08229878
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.07964826
92Influenza A_Homo sapiens_hsa051640.06347378
93Pathways in cancer_Homo sapiens_hsa052000.05390232
94Renin-angiotensin system_Homo sapiens_hsa046140.05100227
95Fatty acid biosynthesis_Homo sapiens_hsa000610.05028266
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.03908356
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.03747042
98Platelet activation_Homo sapiens_hsa046110.03595481
99Insulin signaling pathway_Homo sapiens_hsa049100.03187366
100Proteasome_Homo sapiens_hsa030500.03181001

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