HIST1H2AL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)9.36334196
2DNA replication-dependent nucleosome organization (GO:0034723)9.36334196
3chromatin assembly (GO:0031497)5.88314277
4nucleosome assembly (GO:0006334)5.59710526
5regulation of histone H3-K9 methylation (GO:0051570)5.50616603
6nuclear pore organization (GO:0006999)5.32741254
7nuclear pore complex assembly (GO:0051292)5.19783905
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.06878765
9protein-DNA complex assembly (GO:0065004)4.80918684
10heterochromatin organization (GO:0070828)4.80486983
11chromatin remodeling at centromere (GO:0031055)4.80424148
12chromatin assembly or disassembly (GO:0006333)4.78930863
13nucleosome organization (GO:0034728)4.72738368
14protein localization to kinetochore (GO:0034501)4.71025358
15CENP-A containing nucleosome assembly (GO:0034080)4.61601551
16folic acid-containing compound biosynthetic process (GO:0009396)4.57206292
17protein K6-linked ubiquitination (GO:0085020)4.50096799
18antibacterial humoral response (GO:0019731)4.42884701
19histone exchange (GO:0043486)4.22207364
20protein-DNA complex subunit organization (GO:0071824)4.19772766
21pore complex assembly (GO:0046931)4.10706150
22DNA replication initiation (GO:0006270)4.10701883
23antimicrobial humoral response (GO:0019730)4.10600903
24innate immune response in mucosa (GO:0002227)4.07973467
25DNA strand elongation involved in DNA replication (GO:0006271)4.05799447
26B cell receptor signaling pathway (GO:0050853)4.03662295
27protein localization to chromosome, centromeric region (GO:0071459)4.02110269
28defense response to Gram-positive bacterium (GO:0050830)3.96406179
29chromosome condensation (GO:0030261)3.94946032
30DNA unwinding involved in DNA replication (GO:0006268)3.94275612
31DNA replication-independent nucleosome organization (GO:0034724)3.90824764
32DNA replication-independent nucleosome assembly (GO:0006336)3.90824764
33mitotic recombination (GO:0006312)3.90705059
34regulation of centriole replication (GO:0046599)3.84038488
35telomere maintenance via semi-conservative replication (GO:0032201)3.78622509
36DNA strand elongation (GO:0022616)3.78518486
37immunoglobulin mediated immune response (GO:0016064)3.77405185
38telomere maintenance via recombination (GO:0000722)3.67915811
39V(D)J recombination (GO:0033151)3.65903859
40regulation of posttranscriptional gene silencing (GO:0060147)3.65501146
41regulation of gene silencing by miRNA (GO:0060964)3.65501146
42regulation of gene silencing by RNA (GO:0060966)3.65501146
43negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.65125830
44mitotic chromosome condensation (GO:0007076)3.63681781
45regulation of centrosome cycle (GO:0046605)3.60551655
46sister chromatid segregation (GO:0000819)3.58361161
47positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.55805588
48DNA packaging (GO:0006323)3.51074042
49B cell proliferation (GO:0042100)3.50328020
50kinetochore organization (GO:0051383)3.49268238
51dosage compensation (GO:0007549)3.41988917
52mitotic nuclear envelope disassembly (GO:0007077)3.40760935
53mucosal immune response (GO:0002385)3.39371415
54B cell mediated immunity (GO:0019724)3.38474094
55negative regulation of B cell apoptotic process (GO:0002903)3.37459259
56negative regulation of DNA repair (GO:0045738)3.34190440
57chaperone-mediated protein complex assembly (GO:0051131)3.32148635
58regulation of helicase activity (GO:0051095)3.30780053
59mitotic sister chromatid segregation (GO:0000070)3.30079439
60T-helper 1 type immune response (GO:0042088)3.28078741
61viral mRNA export from host cell nucleus (GO:0046784)3.26399559
62membrane disassembly (GO:0030397)3.23415717
63nuclear envelope disassembly (GO:0051081)3.23415717
64organ or tissue specific immune response (GO:0002251)3.23131716
65ATP-dependent chromatin remodeling (GO:0043044)3.17405530
66mitotic metaphase plate congression (GO:0007080)3.15566441
67regulation of centrosome duplication (GO:0010824)3.14291388
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.13677139
69regulation of sister chromatid cohesion (GO:0007063)3.13009888
70mature B cell differentiation involved in immune response (GO:0002313)3.11326903
71binding of sperm to zona pellucida (GO:0007339)3.11325045
72IMP biosynthetic process (GO:0006188)3.08518441
73microtubule depolymerization (GO:0007019)3.07321559
74pteridine-containing compound biosynthetic process (GO:0042559)3.06775528
75regulation of gene silencing (GO:0060968)3.04781998
76nucleobase biosynthetic process (GO:0046112)3.03042945
77ribosomal large subunit biogenesis (GO:0042273)3.02412560
78DNA replication checkpoint (GO:0000076)3.00440520
79regulation of megakaryocyte differentiation (GO:0045652)3.00292888
80DNA synthesis involved in DNA repair (GO:0000731)2.99885072
81T cell lineage commitment (GO:0002360)2.99316857
82metaphase plate congression (GO:0051310)2.98480832
83positive regulation of histone methylation (GO:0031062)2.97679881
84T cell migration (GO:0072678)2.96401300
85regulation of chromosome segregation (GO:0051983)2.96124997
86ribosome assembly (GO:0042255)2.96076980
87spindle checkpoint (GO:0031577)2.94543364
88regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94245978
89DNA duplex unwinding (GO:0032508)2.94181569
90DNA geometric change (GO:0032392)2.93747087
91paraxial mesoderm development (GO:0048339)2.90719010
92somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90233506
93somatic hypermutation of immunoglobulin genes (GO:0016446)2.90233506
94ncRNA catabolic process (GO:0034661)2.90081386
95telomere maintenance (GO:0000723)2.88952933
96regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88610576
97mitotic sister chromatid cohesion (GO:0007064)2.88454059
98tetrahydrofolate metabolic process (GO:0046653)2.88390421
99nucleotide-excision repair, DNA gap filling (GO:0006297)2.87026634
100telomere organization (GO:0032200)2.86725318
101attachment of spindle microtubules to kinetochore (GO:0008608)2.86388521
102regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.85858443
103sperm-egg recognition (GO:0035036)2.85801572
104IMP metabolic process (GO:0046040)2.85370583
105DNA conformation change (GO:0071103)2.85158164
106meiotic chromosome segregation (GO:0045132)2.84333400
107DNA ligation (GO:0006266)2.83996449
108negative regulation of mitotic sister chromatid separation (GO:2000816)2.83817315
109negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83817315
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.83817315
111negative regulation of sister chromatid segregation (GO:0033046)2.83817315
112spindle assembly checkpoint (GO:0071173)2.83788367
113telomere maintenance via telomere lengthening (GO:0010833)2.83354187
114negative regulation of chromosome segregation (GO:0051985)2.83316784
115mitotic G2/M transition checkpoint (GO:0044818)2.83185525
116spliceosomal tri-snRNP complex assembly (GO:0000244)2.82304115
117antigen processing and presentation of endogenous antigen (GO:0019883)2.81979216
118maturation of 5.8S rRNA (GO:0000460)2.81326766
119somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.80660530
120somatic cell DNA recombination (GO:0016444)2.80660530
121regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.80509730
122establishment of chromosome localization (GO:0051303)2.80182461
123histone-serine phosphorylation (GO:0035404)2.80051096
124proline biosynthetic process (GO:0006561)2.79848862
125negative T cell selection (GO:0043383)2.79075279
126tongue development (GO:0043586)2.77453601
127non-recombinational repair (GO:0000726)2.72996041
128double-strand break repair via nonhomologous end joining (GO:0006303)2.72996041
129regulation of B cell receptor signaling pathway (GO:0050855)2.72761102
130humoral immune response (GO:0006959)2.71115494
131antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70508314
132regulation of B cell apoptotic process (GO:0002902)2.69403951
133regulation of translational fidelity (GO:0006450)2.69378954
134positive regulation of macrophage cytokine production (GO:0060907)2.68144826
135negative thymic T cell selection (GO:0045060)2.68141078
136positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.67922323
137positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.67922323
138positive regulation of mitotic sister chromatid separation (GO:1901970)2.67922323
139maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66367724
140DNA topological change (GO:0006265)2.63653016
141positive regulation of chromosome segregation (GO:0051984)2.63270335
142positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.62767914
143positive regulation of alpha-beta T cell proliferation (GO:0046641)2.61569105
144B cell homeostasis (GO:0001782)2.61383082
145mature B cell differentiation (GO:0002335)2.59428875
146positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.59097146
147translesion synthesis (GO:0019985)2.58447076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.17081516
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.45063398
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.86925905
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.75335408
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.05792525
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.79750670
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.74253472
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61156167
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.36655994
10MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.34176103
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27009755
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21920984
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16297974
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04972042
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.9388772
16MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98886740
17* E2F1_21310950_ChIP-Seq_MCF-7_Human1.86475269
18CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.84947440
19MYC_22102868_ChIP-Seq_BL_Human1.82811017
20ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81684478
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77082888
22GATA1_22025678_ChIP-Seq_K562_Human1.65789113
23* SOX2_16153702_ChIP-ChIP_HESCs_Human1.65123285
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.64698842
25HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.62022048
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57429387
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56974168
28AR_21909140_ChIP-Seq_LNCAP_Human1.55692361
29IRF1_19129219_ChIP-ChIP_H3396_Human1.54963802
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51935449
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51046016
32SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50118121
33KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.47016259
34VDR_21846776_ChIP-Seq_THP-1_Human1.46596845
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43106710
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42972732
37VDR_23849224_ChIP-Seq_CD4+_Human1.41624847
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38823152
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38755719
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.38160750
41ELK1_19687146_ChIP-ChIP_HELA_Human1.36427710
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35917223
43SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.32850554
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32753529
45* NANOG_16153702_ChIP-ChIP_HESCs_Human1.31518437
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31478800
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27909497
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.24851709
49XRN2_22483619_ChIP-Seq_HELA_Human1.23866402
50CIITA_25753668_ChIP-Seq_RAJI_Human1.23193077
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.23069637
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22017596
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21300696
54MAF_26560356_Chip-Seq_TH1_Human1.19910073
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17547647
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16976791
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16286484
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.14691440
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13056357
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12577392
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11979867
62FOXP3_21729870_ChIP-Seq_TREG_Human1.10457832
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09288952
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08877916
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.07473648
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07389428
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06906046
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06396794
69ETS1_22383799_ChIP-Seq_G1ME_Mouse1.04099375
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02664324
71SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01018762
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97696532
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96813506
74* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96670986
75DCP1A_22483619_ChIP-Seq_HELA_Human0.93743444
76TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91791952
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91776657
78MYB_26560356_Chip-Seq_TH1_Human0.90383136
79ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89424830
80EGR1_19374776_ChIP-ChIP_THP-1_Human0.88846640
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86675284
82ELF1_17652178_ChIP-ChIP_JURKAT_Human0.85909879
83TP63_17297297_ChIP-ChIP_HaCaT_Human0.85058571
84ZNF263_19887448_ChIP-Seq_K562_Human0.82523713
85THAP11_20581084_ChIP-Seq_MESCs_Mouse0.82375119
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.80813423
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80533932
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80351557
89TTF2_22483619_ChIP-Seq_HELA_Human0.78264048
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78232728
91UTX_26944678_Chip-Seq_JUKART_Human0.78092677
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77715232
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.77710933
94GABP_19822575_ChIP-Seq_HepG2_Human0.76431472
95MYC_18940864_ChIP-ChIP_HL60_Human0.76297599
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74795796
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.74787999
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.73457221
99MYB_26560356_Chip-Seq_TH2_Human0.73390639
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.72786658
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.72055018
102VDR_24763502_ChIP-Seq_THP-1_Human0.71540990
103ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.71372365
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.70760765
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69323507
106* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.69097152
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.68759616
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.68519783
109SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.68507975
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.65575691
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.64675076
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.64529768
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.64388705
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.64193773
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.64191313
116SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.64083949
117ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.64052256
118KLF4_18555785_ChIP-Seq_MESCs_Mouse0.63051137
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.62838122
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.61949162
121PKCTHETA_26484144_Chip-Seq_BREAST_Human0.61056470
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.60380352
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.59869882
124TFEB_21752829_ChIP-Seq_HELA_Human0.59114071
125* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.58998679
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.58973894
127KDM5A_27292631_Chip-Seq_BREAST_Human0.58937889
128MAF_26560356_Chip-Seq_TH2_Human0.58860847
129POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.58271592
130SRF_21415370_ChIP-Seq_HL-1_Mouse0.57148197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.30517188
2MP0005645_abnormal_hypothalamus_physiol4.02483708
3MP0000685_abnormal_immune_system3.93485030
4MP0003806_abnormal_nucleotide_metabolis3.61034739
5MP0010094_abnormal_chromosome_stability3.59235834
6MP0003705_abnormal_hypodermis_morpholog3.26896350
7MP0003763_abnormal_thymus_physiology3.17592342
8MP0003111_abnormal_nucleus_morphology3.17092725
9MP0003123_paternal_imprinting3.05447590
10MP0004957_abnormal_blastocyst_morpholog3.01920028
11MP0010307_abnormal_tumor_latency2.85866758
12MP0002396_abnormal_hematopoietic_system2.84964269
13MP0005671_abnormal_response_to2.82239108
14MP0003077_abnormal_cell_cycle2.79010016
15MP0001835_abnormal_antigen_presentation2.70838444
16MP0005410_abnormal_fertilization2.61011056
17MP0008438_abnormal_cutaneous_collagen2.55864325
18MP0008058_abnormal_DNA_repair2.47041549
19MP0001800_abnormal_humoral_immune2.42759120
20MP0002166_altered_tumor_susceptibility2.35434481
21MP0002009_preneoplasia2.34814528
22MP0010030_abnormal_orbit_morphology2.33218893
23MP0001790_abnormal_immune_system2.27018844
24MP0005387_immune_system_phenotype2.27018844
25MP0008932_abnormal_embryonic_tissue2.18174734
26MP0000537_abnormal_urethra_morphology2.15459331
27MP0002398_abnormal_bone_marrow2.15207969
28MP0001730_embryonic_growth_arrest2.08742148
29MP0009053_abnormal_anal_canal2.07470778
30MP0002139_abnormal_hepatobiliary_system1.95040277
31MP0005000_abnormal_immune_tolerance1.88344416
32MP0008007_abnormal_cellular_replicative1.87096078
33MP0005275_abnormal_skin_tensile1.86976510
34MP0010352_gastrointestinal_tract_polyps1.85678918
35MP0005076_abnormal_cell_differentiation1.80453809
36MP0003890_abnormal_embryonic-extraembry1.79575961
37MP0002722_abnormal_immune_system1.77513621
38MP0002006_tumorigenesis1.77294967
39MP0003121_genomic_imprinting1.76695130
40MP0000703_abnormal_thymus_morphology1.75399541
41MP0000689_abnormal_spleen_morphology1.70593194
42MP0003941_abnormal_skin_development1.69062180
43MP0010234_abnormal_vibrissa_follicle1.66261270
44MP0000350_abnormal_cell_proliferation1.63696841
45MP0002160_abnormal_reproductive_system1.61590917
46MP0002452_abnormal_antigen_presenting1.58904070
47MP0002877_abnormal_melanocyte_morpholog1.58705086
48MP0008057_abnormal_DNA_replication1.57365570
49MP0002420_abnormal_adaptive_immunity1.57203843
50MP0004808_abnormal_hematopoietic_stem1.55993974
51MP0003937_abnormal_limbs/digits/tail_de1.55050915
52MP0000716_abnormal_immune_system1.53226910
53MP0001661_extended_life_span1.52397647
54MP0003183_abnormal_peptide_metabolism1.51673955
55MP0001819_abnormal_immune_cell1.50679481
56MP0002723_abnormal_immune_serum1.50092975
57MP0002429_abnormal_blood_cell1.49614490
58MP0005360_urolithiasis1.49136138
59MP0004197_abnormal_fetal_growth/weight/1.48414296
60MP0001727_abnormal_embryo_implantation1.42832246
61MP0001293_anophthalmia1.38390293
62MP0002085_abnormal_embryonic_tissue1.33774132
63MP0001672_abnormal_embryogenesis/_devel1.31829663
64MP0005380_embryogenesis_phenotype1.31829663
65MP0001697_abnormal_embryo_size1.29885794
66MP0005310_abnormal_salivary_gland1.28124578
67MP0002086_abnormal_extraembryonic_tissu1.27495589
68MP0005389_reproductive_system_phenotype1.25897013
69MP0002084_abnormal_developmental_patter1.23871130
70MP0003718_maternal_effect1.23410361
71MP0003656_abnormal_erythrocyte_physiolo1.22838745
72MP0002080_prenatal_lethality1.20692288
73MP0002210_abnormal_sex_determination1.19208119
74MP0003786_premature_aging1.18916830
75MP0009046_muscle_twitch1.16495232
76MP0001929_abnormal_gametogenesis1.15034923
77MP0008877_abnormal_DNA_methylation1.14662504
78MP0005503_abnormal_tendon_morphology1.11329073
79MP0005025_abnormal_response_to1.09593050
80MP0001145_abnormal_male_reproductive1.07279520
81MP0002282_abnormal_trachea_morphology1.07255463
82MP0002138_abnormal_hepatobiliary_system1.06853617
83MP0003303_peritoneal_inflammation1.04684652
84MP0002111_abnormal_tail_morphology1.03032029
85MP0002697_abnormal_eye_size1.02479997
86MP0003186_abnormal_redox_activity1.02051823
87MP0003984_embryonic_growth_retardation1.00907772
88MP0004381_abnormal_hair_follicle0.99874079
89MP0001243_abnormal_dermal_layer0.99798940
90MP0002088_abnormal_embryonic_growth/wei0.98704831
91MP0010155_abnormal_intestine_physiology0.98638778
92MP0002092_abnormal_eye_morphology0.98302396
93MP0000653_abnormal_sex_gland0.95831563
94MP0003698_abnormal_male_reproductive0.93368719
95MP0003119_abnormal_digestive_system0.92993649
96MP0004947_skin_inflammation0.92303937
97MP0008789_abnormal_olfactory_epithelium0.90949440
98MP0003300_gastrointestinal_ulcer0.89942938
99MP0000490_abnormal_crypts_of0.89062623
100MP0005083_abnormal_biliary_tract0.88810607
101MP0009697_abnormal_copulation0.88484382
102MP0002019_abnormal_tumor_incidence0.87399894
103MP0004185_abnormal_adipocyte_glucose0.86295117
104MP0000358_abnormal_cell_content/0.86045902
105MP0006035_abnormal_mitochondrial_morpho0.85827733
106MP0001845_abnormal_inflammatory_respons0.85683054
107MP0001849_ear_inflammation0.84953147
108MP0003315_abnormal_perineum_morphology0.83998516
109MP0000428_abnormal_craniofacial_morphol0.83384065
110MP0003283_abnormal_digestive_organ0.83104800
111MP0009333_abnormal_splenocyte_physiolog0.82836491
112MP0002163_abnormal_gland_morphology0.82826458
113MP0000313_abnormal_cell_death0.82357803
114MP0002405_respiratory_system_inflammati0.81996478
115MP0005085_abnormal_gallbladder_physiolo0.81876135
116MP0004264_abnormal_extraembryonic_tissu0.81041600
117MP0009785_altered_susceptibility_to0.80421002
118MP0006054_spinal_hemorrhage0.80266599
119MP0003385_abnormal_body_wall0.79936970
120MP0009672_abnormal_birth_weight0.79571089
121MP0003942_abnormal_urinary_system0.79288995
122MP0005451_abnormal_body_composition0.78970840
123MP0005621_abnormal_cell_physiology0.78539894
124MP0002060_abnormal_skin_morphology0.78177305
125MP0005023_abnormal_wound_healing0.77666613
126MP0009703_decreased_birth_body0.76249372
127MP0005408_hypopigmentation0.75877471
128MP0005187_abnormal_penis_morphology0.75182140
129MP0004147_increased_porphyrin_level0.74569569
130MP0002098_abnormal_vibrissa_morphology0.74017975
131MP0005384_cellular_phenotype0.73974799
132MP0001119_abnormal_female_reproductive0.73732703
133MP0004272_abnormal_basement_membrane0.73072826
134MP0003566_abnormal_cell_adhesion0.71733528
135MP0009278_abnormal_bone_marrow0.70853222
136MP0005220_abnormal_exocrine_pancreas0.69887497
137MP0002161_abnormal_fertility/fecundity0.69703403
138MP0003115_abnormal_respiratory_system0.68970656
139MP0000015_abnormal_ear_pigmentation0.68580017
140MP0003567_abnormal_fetal_cardiomyocyte0.68453235
141MP0009931_abnormal_skin_appearance0.68443576
142MP0005075_abnormal_melanosome_morpholog0.65754628
143MP0003252_abnormal_bile_duct0.65748024
144MP0001919_abnormal_reproductive_system0.65279509
145MP0001915_intracranial_hemorrhage0.64550359
146MP0005367_renal/urinary_system_phenotyp0.64531312
147MP0000516_abnormal_urinary_system0.64531312
148MP0000432_abnormal_head_morphology0.63895141
149MP0000049_abnormal_middle_ear0.63672628
150MP0001191_abnormal_skin_condition0.63594800
151MP0001545_abnormal_hematopoietic_system0.63155586
152MP0005397_hematopoietic_system_phenotyp0.63155586
153MP0002233_abnormal_nose_morphology0.62966425
154MP0005501_abnormal_skin_physiology0.62058926
155MP0002132_abnormal_respiratory_system0.60800074
156MP0005623_abnormal_meninges_morphology0.60220833
157MP0002083_premature_death0.60114399
158MP0001873_stomach_inflammation0.60101764
159MP0003878_abnormal_ear_physiology0.59795423
160MP0005377_hearing/vestibular/ear_phenot0.59795423
161MP0002148_abnormal_hypersensitivity_rea0.55878923
162MP0005647_abnormal_sex_gland0.55522614
163MP0000371_diluted_coat_color0.54950132
164MP0004233_abnormal_muscle_weight0.52921148
165MP0001853_heart_inflammation0.51771426
166MP0005464_abnormal_platelet_physiology0.51626601

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)6.80698981
2IgA deficiency (HP:0002720)6.51191393
3Gastrointestinal stroma tumor (HP:0100723)6.31608644
4Recurrent sinusitis (HP:0011108)5.03554201
5Agammaglobulinemia (HP:0004432)4.99196441
6Colitis (HP:0002583)4.47512885
7Cellulitis (HP:0100658)4.42183426
8Impulsivity (HP:0100710)4.34520830
9Recurrent bronchitis (HP:0002837)4.26255302
10Lymphopenia (HP:0001888)4.16359429
11Abnormality of cells of the lymphoid lineage (HP:0012140)4.06662955
12B lymphocytopenia (HP:0010976)3.74013532
13Dry hair (HP:0011359)3.68479596
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.63457658
15Chromsome breakage (HP:0040012)3.60611464
16Abnormality of chromosome stability (HP:0003220)3.53343097
17Squamous cell carcinoma (HP:0002860)3.51765555
18Meningitis (HP:0001287)3.47039143
19Abnormality of B cell number (HP:0010975)3.46911070
20Ependymoma (HP:0002888)3.45097305
21Onycholysis (HP:0001806)3.22109324
22Selective tooth agenesis (HP:0001592)3.17383430
23IgG deficiency (HP:0004315)3.12196934
24Basal cell carcinoma (HP:0002671)3.11501710
25Emphysema (HP:0002097)3.11232755
26Reticulocytopenia (HP:0001896)3.05550135
27Lymphoma (HP:0002665)3.04573500
28Recurrent viral infections (HP:0004429)3.03751536
29Chronic diarrhea (HP:0002028)3.00006362
30Medulloblastoma (HP:0002885)2.99605256
31Abnormality of pyrimidine metabolism (HP:0004353)2.95920644
32Hypoglycemic seizures (HP:0002173)2.95110593
33Recurrent pneumonia (HP:0006532)2.91516183
34Hypobetalipoproteinemia (HP:0003563)2.89396061
35Inflammation of the large intestine (HP:0002037)2.82725133
36Osteomyelitis (HP:0002754)2.78844347
37Colon cancer (HP:0003003)2.78229842
38Erythema (HP:0010783)2.77430992
39Astrocytoma (HP:0009592)2.74999741
40Abnormality of the astrocytes (HP:0100707)2.74999741
41Vasculitis (HP:0002633)2.74361137
42Chronic bronchitis (HP:0004469)2.74340093
43Leukopenia (HP:0001882)2.73242368
44Prostate neoplasm (HP:0100787)2.72214910
45Recurrent lower respiratory tract infections (HP:0002783)2.71240982
46Gastrointestinal inflammation (HP:0004386)2.71208429
47Abnormality of T cell physiology (HP:0011840)2.70413318
48Urticaria (HP:0001025)2.69584904
49Wrist flexion contracture (HP:0001239)2.68979924
50Meckel diverticulum (HP:0002245)2.66751315
51Panhypogammaglobulinemia (HP:0003139)2.65491978
52Rhabdomyosarcoma (HP:0002859)2.63349232
53Birth length less than 3rd percentile (HP:0003561)2.60778136
54Hypoglycemic coma (HP:0001325)2.59866502
55Ridged nail (HP:0001807)2.59355484
56Glioma (HP:0009733)2.58170752
57Abnormality of the prostate (HP:0008775)2.56275616
58Cholecystitis (HP:0001082)2.55759181
59Abnormal gallbladder physiology (HP:0012438)2.55759181
60Mediastinal lymphadenopathy (HP:0100721)2.53009941
61Autoimmune hemolytic anemia (HP:0001890)2.52461592
62Biliary tract neoplasm (HP:0100574)2.48990655
63Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.47253771
64Abnormality of the ileum (HP:0001549)2.43557066
65Thyroiditis (HP:0100646)2.42036412
66Nephroblastoma (Wilms tumor) (HP:0002667)2.39958873
67Hyperinsulinemic hypoglycemia (HP:0000825)2.36233302
68Embryonal renal neoplasm (HP:0011794)2.34888407
69Abnormality of the fingertips (HP:0001211)2.34794359
70Microvesicular hepatic steatosis (HP:0001414)2.33232120
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.33118516
72Small intestinal stenosis (HP:0012848)2.32483926
73Duodenal stenosis (HP:0100867)2.32483926
74Agnosia (HP:0010524)2.32043467
75Spastic diplegia (HP:0001264)2.30734958
76Abnormal lung lobation (HP:0002101)2.30401524
77Ankle contracture (HP:0006466)2.28625565
78Secondary amenorrhea (HP:0000869)2.25971322
79Breast carcinoma (HP:0003002)2.25345499
80Poikilocytosis (HP:0004447)2.24061707
81Sloping forehead (HP:0000340)2.22323808
82Verrucae (HP:0200043)2.22099521
83Papilloma (HP:0012740)2.22099521
84Eczematoid dermatitis (HP:0000976)2.22067410
85Abnormality of monocarboxylic acid metabolism (HP:0010996)2.22028820
86Skin rash (HP:0000988)2.21192274
87Sparse scalp hair (HP:0002209)2.21026650
88Hepatitis (HP:0012115)2.20884770
89Breast hypoplasia (HP:0003187)2.20206995
90Hypolipoproteinemia (HP:0010981)2.19446669
91Abnormality of the preputium (HP:0100587)2.18683138
92Ovarian neoplasm (HP:0100615)2.18650637
93Neoplasm of the pancreas (HP:0002894)2.18438323
94Bronchitis (HP:0012387)2.17225428
95Combined immunodeficiency (HP:0005387)2.17053031
96Cutaneous melanoma (HP:0012056)2.16149063
97Slender long bone (HP:0003100)2.15730886
98Abnormal delayed hypersensitivity skin test (HP:0002963)2.14330797
99Recurrent bacterial skin infections (HP:0005406)2.13278106
100Megaloblastic anemia (HP:0001889)2.12834898
101Aplasia/Hypoplasia of the sternum (HP:0006714)2.12508533
102Freckling (HP:0001480)2.09737329
103Sepsis (HP:0100806)2.09553796
104Restrictive lung disease (HP:0002091)2.09130453
105Recurrent otitis media (HP:0000403)2.08801267
106Viral hepatitis (HP:0006562)2.08469696
107Cafe-au-lait spot (HP:0000957)2.08280668
108Abnormality of reticulocytes (HP:0004312)2.08094442
109Hypopigmentation of the fundus (HP:0007894)2.08061809
110Neoplasm of the colon (HP:0100273)2.06788147
111Symptomatic seizures (HP:0011145)2.06351400
112Intestinal polyposis (HP:0200008)2.06282831
113Missing ribs (HP:0000921)2.05385941
11411 pairs of ribs (HP:0000878)2.05321387
115Abnormal biliary tract morphology (HP:0012440)2.04180420
116Mesomelia (HP:0003027)2.03371641
117Intrahepatic cholestasis (HP:0001406)2.02967877
118Clubbing of toes (HP:0100760)2.01885655
119Abnormality of the duodenum (HP:0002246)2.00218380
120Patellar aplasia (HP:0006443)1.99304695
121Pancreatic islet-cell hyperplasia (HP:0004510)1.99261840
122Gonadotropin excess (HP:0000837)1.98692668
123Severe combined immunodeficiency (HP:0004430)1.97945534
124Facial cleft (HP:0002006)1.97792347
125Acanthocytosis (HP:0001927)1.97725055
126Acute lymphatic leukemia (HP:0006721)1.97470673
127Orthostatic hypotension (HP:0001278)1.95550810
128Abnormality of T cells (HP:0002843)1.93281071
129Insomnia (HP:0100785)1.91125664
130Abnormality of DNA repair (HP:0003254)1.90882260
131Myelodysplasia (HP:0002863)1.90277815
132Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89099630
133Intestinal polyp (HP:0005266)1.88776915
134Abnormality of dentin (HP:0010299)1.88016046
135Cerebellar dysplasia (HP:0007033)1.87664662
136Aplasia/Hypoplasia of the patella (HP:0006498)1.87527471
137Broad distal phalanx of finger (HP:0009836)1.86629449
138Short 5th finger (HP:0009237)1.86079110
139Cutaneous photosensitivity (HP:0000992)1.83938858
140Amaurosis fugax (HP:0100576)1.82886508
141Neoplasm of the liver (HP:0002896)1.81931867
142Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80905076
143Hyperacusis (HP:0010780)1.78981198
144Neoplasm of striated muscle (HP:0009728)1.78952123
145Absent radius (HP:0003974)1.78367342
146Hypergonadotropic hypogonadism (HP:0000815)1.73844343
147Poikiloderma (HP:0001029)1.73711889
148Recurrent abscess formation (HP:0002722)1.73612571
149Prominent nose (HP:0000448)1.73601772
150Deep palmar crease (HP:0006191)1.73418735
151Osteomalacia (HP:0002749)1.73072387
152Absent thumb (HP:0009777)1.73003358
153Adenoma sebaceum (HP:0009720)1.72763560
154Angiofibromas (HP:0010615)1.72763560
155Atresia of the external auditory canal (HP:0000413)1.72604486
156Hypoplasia of the thymus (HP:0000778)1.70501359
157Abnormality of the calcaneus (HP:0008364)1.70186164
158Increased IgM level (HP:0003496)1.69627803
159Duplicated collecting system (HP:0000081)1.69251171
160Hepatocellular carcinoma (HP:0001402)1.69011610
161Entropion (HP:0000621)1.68707132
162Abnormality of the carotid arteries (HP:0005344)1.68315120
163Neoplasm of the rectum (HP:0100743)1.68174916
164Recurrent fungal infections (HP:0002841)1.67807807
165Aplasia/hypoplasia of the humerus (HP:0006507)1.66730972
166Abnormality of male internal genitalia (HP:0000022)1.66263586
167Neutropenia (HP:0001875)1.64947775
168Hypoalphalipoproteinemia (HP:0003233)1.64800332
169Abnormality of incisor morphology (HP:0011063)1.64207799
170Abnormal spermatogenesis (HP:0008669)1.63496084
171Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.63484708
172Short 4th metacarpal (HP:0010044)1.63484708
173Tubulointerstitial nephritis (HP:0001970)1.63122817
174Premature ovarian failure (HP:0008209)1.62485299
175Abnormality of the labia minora (HP:0012880)1.62086755
176Aplastic anemia (HP:0001915)1.61887651
177Short humerus (HP:0005792)1.59962532
178Ectopic kidney (HP:0000086)1.59691409
179High pitched voice (HP:0001620)1.59450372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK17.95333999
2ZAK5.93767661
3VRK13.19829607
4CDC73.03443660
5RPS6KA52.70406992
6EIF2AK12.55619531
7ACVR1B2.44669751
8SMG12.43670345
9SRPK12.37699988
10PBK2.33688463
11BUB12.28075216
12PASK2.13453188
13TESK12.06393045
14SCYL22.05399823
15RPS6KA42.02518873
16WEE12.00917453
17NEK21.98885758
18STK41.98079337
19EIF2AK31.81002564
20TAF11.70538676
21AURKB1.52124988
22TTK1.41559346
23EEF2K1.40885340
24NEK11.40822979
25EPHA21.38751135
26PLK11.29791921
27CHEK21.24250437
28DYRK31.18914159
29AURKA1.17240749
30MAP3K81.16617518
31RPS6KB21.13930050
32CDK91.12057795
33BRSK21.06285885
34CDK121.04990573
35TGFBR11.02399222
36FLT31.02021037
37PLK31.00731256
38BRSK11.00549482
39ATR1.00521490
40MAP3K101.00508405
41IRAK40.97811379
42PIM10.95934017
43VRK20.95553930
44NME20.95250070
45DAPK30.92718887
46STK38L0.90436411
47TTN0.90320200
48BTK0.89873827
49MAP4K10.87610591
50FRK0.85788004
51PLK40.85710037
52EIF2AK20.82364317
53PRKD30.78731233
54PRPF4B0.76332045
55ERBB30.75711288
56BLK0.74804934
57SYK0.73025886
58MELK0.72380328
59MAPK150.72368242
60TESK20.71606302
61PKN20.71161924
62BRAF0.68671674
63NEK90.66683703
64PDGFRA0.65873756
65BCKDK0.64961791
66ATM0.62722718
67CHEK10.61946337
68PAK40.60372554
69MET0.59361508
70STK100.57885655
71MAPK110.54982298
72CCNB10.52250990
73TRPM70.51922879
74PRKAA10.50764932
75STK160.50347710
76PKN10.49955357
77CDK70.49764333
78STK30.48802492
79CDK20.48173610
80MKNK10.46368039
81LATS10.45157223
82DDR20.42771207
83TRIB30.42043047
84AKT20.39403646
85MAP3K110.38803723
86LYN0.38609355
87CDK40.38594474
88PIM20.38267866
89MAP3K140.38041707
90ERBB40.37154103
91PAK10.36934856
92CDK80.36652762
93MAPKAPK30.35966476
94MAPKAPK50.35786768
95PDK40.35592821
96PDK30.35592821
97DYRK1B0.35269768
98CDK10.34866834
99ARAF0.34838443
100KDR0.32881828
101JAK20.32496345
102CAMKK20.32249893
103PTK60.31065701
104NLK0.28925534
105TBK10.28680872
106RIPK10.28055542
107LRRK20.26598353
108BRD40.24915239
109IKBKE0.24589291
110CSNK2A10.24088256
111CSNK2A20.23461006
112CSF1R0.23291107
113MAP3K130.23244244
114ERBB20.22978031
115ROCK10.22672161
116BMPR1B0.22239896
117PDK20.21803506
118RPS6KA10.21457233
119CSNK1G30.21230905
120NUAK10.20779651
121MTOR0.19734700
122IKBKB0.19547436
123ICK0.19444289
124RAF10.19439782
125CDK60.19435378
126FER0.18802607
127CSNK1A1L0.17823267
128WNK30.16842379
129MST40.15707762
130PRKDC0.15555817
131PIK3CG0.15333541
132PRKCD0.15005794
133HIPK20.14428798
134PRKCI0.14322653
135CSNK1G10.13845706
136PRKCQ0.13528963
137MAPK140.11669014
138AKT30.11141356
139TEC0.11035324
140MAP3K90.10690553
141MAP2K30.10386475
142CAMK40.09493417
143TSSK60.08662656
144RIPK40.08600704
145CDK150.07845087

Predicted pathways (KEGG)

RankGene SetZ-score
1* Systemic lupus erythematosus_Homo sapiens_hsa053229.96809712
2* Alcoholism_Homo sapiens_hsa050345.58984053
3DNA replication_Homo sapiens_hsa030303.11116578
4Mismatch repair_Homo sapiens_hsa034302.80854742
5Viral carcinogenesis_Homo sapiens_hsa052032.79255846
6One carbon pool by folate_Homo sapiens_hsa006702.30663105
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.97467896
8Primary immunodeficiency_Homo sapiens_hsa053401.95285779
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93267525
10Spliceosome_Homo sapiens_hsa030401.89125604
11Cell cycle_Homo sapiens_hsa041101.85260635
12Nucleotide excision repair_Homo sapiens_hsa034201.84684259
13RNA transport_Homo sapiens_hsa030131.75426918
14Allograft rejection_Homo sapiens_hsa053301.73475832
15Asthma_Homo sapiens_hsa053101.73238047
16Homologous recombination_Homo sapiens_hsa034401.68365839
17Autoimmune thyroid disease_Homo sapiens_hsa053201.62706323
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60964949
19Fanconi anemia pathway_Homo sapiens_hsa034601.60114223
20Selenocompound metabolism_Homo sapiens_hsa004501.59986436
21Base excision repair_Homo sapiens_hsa034101.51274838
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.49668335
23Graft-versus-host disease_Homo sapiens_hsa053321.41738490
24Proteasome_Homo sapiens_hsa030501.37832334
25Pyrimidine metabolism_Homo sapiens_hsa002401.35512341
26Ribosome_Homo sapiens_hsa030101.30986266
27Sulfur metabolism_Homo sapiens_hsa009201.26747804
28Non-homologous end-joining_Homo sapiens_hsa034501.22705738
29Type I diabetes mellitus_Homo sapiens_hsa049401.22295839
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16798585
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.15171430
32RNA polymerase_Homo sapiens_hsa030201.14446166
33Viral myocarditis_Homo sapiens_hsa054161.13865539
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.09585441
35B cell receptor signaling pathway_Homo sapiens_hsa046621.09381911
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96963080
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94117623
38RNA degradation_Homo sapiens_hsa030180.93692867
39Nitrogen metabolism_Homo sapiens_hsa009100.93020795
40p53 signaling pathway_Homo sapiens_hsa041150.90426037
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90298959
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87692195
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82292567
44Protein export_Homo sapiens_hsa030600.81803264
45Leishmaniasis_Homo sapiens_hsa051400.78053285
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74642564
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74358956
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72806307
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70391751
50Basal transcription factors_Homo sapiens_hsa030220.69804626
51Legionellosis_Homo sapiens_hsa051340.67342204
52mRNA surveillance pathway_Homo sapiens_hsa030150.66016599
53Purine metabolism_Homo sapiens_hsa002300.65167641
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63796178
55Fatty acid degradation_Homo sapiens_hsa000710.62551558
56Folate biosynthesis_Homo sapiens_hsa007900.61624876
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59391114
58Chemical carcinogenesis_Homo sapiens_hsa052040.58454933
59Linoleic acid metabolism_Homo sapiens_hsa005910.58224468
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57293692
61Biosynthesis of amino acids_Homo sapiens_hsa012300.56651961
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56300419
63Glutathione metabolism_Homo sapiens_hsa004800.56242102
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.55634691
65Retinol metabolism_Homo sapiens_hsa008300.55092056
66Peroxisome_Homo sapiens_hsa041460.53114106
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.52827533
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52589931
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52104578
70Hematopoietic cell lineage_Homo sapiens_hsa046400.51909392
71Fat digestion and absorption_Homo sapiens_hsa049750.50162999
72Influenza A_Homo sapiens_hsa051640.46939215
73Tryptophan metabolism_Homo sapiens_hsa003800.45655425
74Pyruvate metabolism_Homo sapiens_hsa006200.45473855
75Fructose and mannose metabolism_Homo sapiens_hsa000510.44120038
76Non-small cell lung cancer_Homo sapiens_hsa052230.43849375
77Complement and coagulation cascades_Homo sapiens_hsa046100.43198058
78Antigen processing and presentation_Homo sapiens_hsa046120.43137166
79Pentose phosphate pathway_Homo sapiens_hsa000300.42442640
80Carbon metabolism_Homo sapiens_hsa012000.42275114
81Herpes simplex infection_Homo sapiens_hsa051680.41607512
82Oocyte meiosis_Homo sapiens_hsa041140.39792180
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39750599
84Phenylalanine metabolism_Homo sapiens_hsa003600.38913129
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38396883
86Bladder cancer_Homo sapiens_hsa052190.38351280
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38025952
88Sulfur relay system_Homo sapiens_hsa041220.37664787
89Pancreatic cancer_Homo sapiens_hsa052120.37171962
90HTLV-I infection_Homo sapiens_hsa051660.36699301
91MicroRNAs in cancer_Homo sapiens_hsa052060.36547590
92Tyrosine metabolism_Homo sapiens_hsa003500.36057644
93Chronic myeloid leukemia_Homo sapiens_hsa052200.34885658
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.34875965
95Measles_Homo sapiens_hsa051620.34415197
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34407409
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.34366751
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.34354928
99Hepatitis B_Homo sapiens_hsa051610.33600872
100Vitamin B6 metabolism_Homo sapiens_hsa007500.33581256
101Thyroid cancer_Homo sapiens_hsa052160.32273949
102Butanoate metabolism_Homo sapiens_hsa006500.32140038
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31587920
104TGF-beta signaling pathway_Homo sapiens_hsa043500.31246548
105Arginine biosynthesis_Homo sapiens_hsa002200.30671348
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30189930
107Galactose metabolism_Homo sapiens_hsa000520.29148406
108Epstein-Barr virus infection_Homo sapiens_hsa051690.28233862
109Toxoplasmosis_Homo sapiens_hsa051450.28189843
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27613048
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26257898
112Histidine metabolism_Homo sapiens_hsa003400.24499854
113Colorectal cancer_Homo sapiens_hsa052100.24434958
114Arginine and proline metabolism_Homo sapiens_hsa003300.24336851
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.23477775
116Propanoate metabolism_Homo sapiens_hsa006400.22739523
117Arachidonic acid metabolism_Homo sapiens_hsa005900.22536502
118Staphylococcus aureus infection_Homo sapiens_hsa051500.21898510
119Acute myeloid leukemia_Homo sapiens_hsa052210.21128904
120Small cell lung cancer_Homo sapiens_hsa052220.20539859
121Glioma_Homo sapiens_hsa052140.20422713
122Prion diseases_Homo sapiens_hsa050200.19271701
123Apoptosis_Homo sapiens_hsa042100.19005129
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17606798
125Fatty acid metabolism_Homo sapiens_hsa012120.16489951
126Metabolic pathways_Homo sapiens_hsa011000.16095371
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15944847
128Tuberculosis_Homo sapiens_hsa051520.15658867
129Prostate cancer_Homo sapiens_hsa052150.14729762
130Lysine degradation_Homo sapiens_hsa003100.14192923
131Rheumatoid arthritis_Homo sapiens_hsa053230.13577284
132Tight junction_Homo sapiens_hsa045300.13204238
133Hippo signaling pathway_Homo sapiens_hsa043900.12819939
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.12646143
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.12313437
136HIF-1 signaling pathway_Homo sapiens_hsa040660.11351288
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.10719785
138Toll-like receptor signaling pathway_Homo sapiens_hsa046200.08549861
139Phagosome_Homo sapiens_hsa041450.07823526
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.07736274
141Basal cell carcinoma_Homo sapiens_hsa052170.06216742
142N-Glycan biosynthesis_Homo sapiens_hsa005100.06200834
143Inositol phosphate metabolism_Homo sapiens_hsa005620.05530119
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.05065276
145Endometrial cancer_Homo sapiens_hsa052130.04893088
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.04810351

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