HIST1H2AI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)8.30808660
2DNA replication-dependent nucleosome organization (GO:0034723)8.30808660
3chromatin assembly (GO:0031497)8.14532749
4regulation of histone H3-K9 methylation (GO:0051570)7.31443053
5nucleosome assembly (GO:0006334)7.26843259
6nucleosome organization (GO:0034728)6.32936226
7protein-DNA complex assembly (GO:0065004)6.13658277
8antibacterial humoral response (GO:0019731)5.89125820
9chromatin assembly or disassembly (GO:0006333)5.79096510
10protoporphyrinogen IX metabolic process (GO:0046501)5.76010553
11DNA unwinding involved in DNA replication (GO:0006268)5.68560724
12innate immune response in mucosa (GO:0002227)5.58943214
13nuclear pore complex assembly (GO:0051292)5.57911727
14mitotic chromosome condensation (GO:0007076)5.53540322
15protein-DNA complex subunit organization (GO:0071824)5.52747791
16nuclear pore organization (GO:0006999)5.52251662
17antimicrobial humoral response (GO:0019730)5.50432808
18protein localization to kinetochore (GO:0034501)5.31281977
19sister chromatid segregation (GO:0000819)5.25452934
20protoporphyrinogen IX biosynthetic process (GO:0006782)5.07212835
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.88906999
22mitotic sister chromatid segregation (GO:0000070)4.85809927
23protein localization to chromosome, centromeric region (GO:0071459)4.70009700
24DNA replication initiation (GO:0006270)4.32777083
25negative regulation of histone methylation (GO:0031061)4.30412219
26mucosal immune response (GO:0002385)4.28810811
27pore complex assembly (GO:0046931)4.24394268
28kinetochore organization (GO:0051383)4.17482583
29negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.14214164
30chromatin remodeling at centromere (GO:0031055)4.09770132
31positive regulation of chromosome segregation (GO:0051984)4.07850719
32CENP-A containing nucleosome assembly (GO:0034080)4.05675975
33organ or tissue specific immune response (GO:0002251)4.04585376
34positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.04053950
35positive regulation of mitotic sister chromatid separation (GO:1901970)4.04053950
36positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.04053950
37porphyrin-containing compound biosynthetic process (GO:0006779)4.02634421
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.02387052
39protein K6-linked ubiquitination (GO:0085020)3.98532867
40erythrocyte maturation (GO:0043249)3.97712342
41regulation of DNA endoreduplication (GO:0032875)3.94173491
42DNA strand elongation involved in DNA replication (GO:0006271)3.92803503
43DNA duplex unwinding (GO:0032508)3.90782037
44regulation of gene silencing (GO:0060968)3.90607991
45DNA geometric change (GO:0032392)3.90082315
46defense response to Gram-positive bacterium (GO:0050830)3.85241161
47chromosome condensation (GO:0030261)3.82218670
48microtubule depolymerization (GO:0007019)3.81927880
49mitotic nuclear envelope disassembly (GO:0007077)3.79017582
50folic acid-containing compound biosynthetic process (GO:0009396)3.77006776
51viral mRNA export from host cell nucleus (GO:0046784)3.76525952
52DNA replication-independent nucleosome assembly (GO:0006336)3.76362459
53DNA replication-independent nucleosome organization (GO:0034724)3.76362459
54DNA strand elongation (GO:0022616)3.72017296
55regulation of centriole replication (GO:0046599)3.71653091
56DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.70978476
57dosage compensation (GO:0007549)3.68502740
58meiotic chromosome segregation (GO:0045132)3.67001563
59telomere maintenance via semi-conservative replication (GO:0032201)3.65518736
60mitotic sister chromatid cohesion (GO:0007064)3.61555371
61mitotic recombination (GO:0006312)3.60792430
62nuclear envelope disassembly (GO:0051081)3.59237761
63membrane disassembly (GO:0030397)3.59237761
64regulation of sister chromatid cohesion (GO:0007063)3.57498656
65translesion synthesis (GO:0019985)3.56970085
66pre-miRNA processing (GO:0031054)3.56854134
67positive regulation of histone methylation (GO:0031062)3.55681234
68regulation of gene silencing by miRNA (GO:0060964)3.51257030
69regulation of gene silencing by RNA (GO:0060966)3.51257030
70regulation of posttranscriptional gene silencing (GO:0060147)3.51257030
71attachment of spindle microtubules to kinetochore (GO:0008608)3.50363309
72regulation of centrosome cycle (GO:0046605)3.49080429
73tetrapyrrole biosynthetic process (GO:0033014)3.45511106
74IMP biosynthetic process (GO:0006188)3.44418383
75regulation of spindle organization (GO:0090224)3.44060827
76histone exchange (GO:0043486)3.41780801
77DNA conformation change (GO:0071103)3.34090219
78DNA topological change (GO:0006265)3.33457178
79protein localization to chromosome (GO:0034502)3.31766595
80DNA packaging (GO:0006323)3.31310488
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.31158469
82telomere maintenance via recombination (GO:0000722)3.29515693
83regulation of mitotic spindle organization (GO:0060236)3.27384903
84DNA damage response, signal transduction resulting in transcription (GO:0042772)3.25642087
85regulation of chromosome segregation (GO:0051983)3.25632737
86proline biosynthetic process (GO:0006561)3.25349267
87DNA synthesis involved in DNA repair (GO:0000731)3.24582572
88regulation of megakaryocyte differentiation (GO:0045652)3.24326788
89regulation of translational fidelity (GO:0006450)3.23389921
90postreplication repair (GO:0006301)3.21867234
91DNA replication checkpoint (GO:0000076)3.20405957
92regulation of centrosome duplication (GO:0010824)3.19339813
93chromosome segregation (GO:0007059)3.19030510
94regulation of RNA export from nucleus (GO:0046831)3.19013859
95heme biosynthetic process (GO:0006783)3.14582850
96regulation of histone methylation (GO:0031060)3.13732093
97heterochromatin organization (GO:0070828)3.10566286
98ATP-dependent chromatin remodeling (GO:0043044)3.10314114
99mitotic metaphase plate congression (GO:0007080)3.09498549
100telomere maintenance (GO:0000723)3.08582384
101kinetochore assembly (GO:0051382)3.07522011
102telomere organization (GO:0032200)3.07291323
103metaphase plate congression (GO:0051310)3.06688780
104regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06664919
105spindle checkpoint (GO:0031577)3.03969467
106nucleotide-excision repair, DNA gap filling (GO:0006297)3.02502146
107erythrocyte development (GO:0048821)3.01641870
108non-recombinational repair (GO:0000726)2.99486837
109double-strand break repair via nonhomologous end joining (GO:0006303)2.99486837
110B cell receptor signaling pathway (GO:0050853)2.97829982
111telomere maintenance via telomere lengthening (GO:0010833)2.97145443
112negative regulation of B cell apoptotic process (GO:0002903)2.94890542
113peptidyl-arginine omega-N-methylation (GO:0035247)2.89853749
114V(D)J recombination (GO:0033151)2.88029214
115DNA ligation (GO:0006266)2.87425571
116negative regulation of chromosome segregation (GO:0051985)2.87002259
117regulation of mammary gland epithelial cell proliferation (GO:0033599)2.76843373
118maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74559712
119regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.72126249
120immunoglobulin mediated immune response (GO:0016064)2.70496538
121positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.69349646
122regulation of sister chromatid segregation (GO:0033045)2.68877351
123regulation of mitotic sister chromatid separation (GO:0010965)2.68877351
124regulation of mitotic sister chromatid segregation (GO:0033047)2.68877351
125mitotic spindle assembly checkpoint (GO:0007094)2.66238363
126B cell proliferation (GO:0042100)2.65595554
127negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.64408392
128negative regulation of mitotic sister chromatid segregation (GO:0033048)2.64408392
129negative regulation of mitotic sister chromatid separation (GO:2000816)2.64408392
130negative regulation of sister chromatid segregation (GO:0033046)2.64408392
131negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.64408392
132somatic hypermutation of immunoglobulin genes (GO:0016446)2.64121117
133somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64121117
134deoxyribonucleotide biosynthetic process (GO:0009263)2.62648108
135spindle assembly checkpoint (GO:0071173)2.62546206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.40200557
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.02322996
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.41433841
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.71924163
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.39308815
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.31332561
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67940000
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45517070
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39097454
10* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.32110669
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.19248446
12* SOX2_16153702_ChIP-ChIP_HESCs_Human2.12836720
13* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.08876331
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.9231181
15NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89465083
16* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.82711920
17MYC_18555785_ChIP-Seq_MESCs_Mouse1.80244916
18* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.77940943
19* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66744116
20SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.65544239
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64133888
22POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64131229
23ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59071820
24SOX2_18555785_ChIP-Seq_MESCs_Mouse1.58334847
25IRF1_19129219_ChIP-ChIP_H3396_Human1.55498443
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51844778
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.50137880
28AR_21909140_ChIP-Seq_LNCAP_Human1.48933733
29KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.47383055
30* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.38128497
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37314119
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34104453
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30311650
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30128813
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29391084
36GATA1_22025678_ChIP-Seq_K562_Human1.28215919
37* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27640632
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27536117
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25756727
40* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25146539
41* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25100230
42* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21577236
43VDR_23849224_ChIP-Seq_CD4+_Human1.18966689
44NANOG_16153702_ChIP-ChIP_HESCs_Human1.18654142
45MYC_22102868_ChIP-Seq_BL_Human1.18172199
46* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.12491832
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12050340
48TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11460332
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04808566
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04333677
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02641983
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98480041
53ELK1_19687146_ChIP-ChIP_HELA_Human0.98214434
54VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96353063
55GATA1_19941826_ChIP-Seq_K562_Human0.96175623
56MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95461587
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95101284
58DCP1A_22483619_ChIP-Seq_HELA_Human0.94720245
59THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94177499
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93306885
61BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93249875
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92575856
63SALL1_21062744_ChIP-ChIP_HESCs_Human0.92565169
64E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92266033
65PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90479202
66VDR_21846776_ChIP-Seq_THP-1_Human0.88603944
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88455613
68STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87972096
69ETS1_20019798_ChIP-Seq_JURKAT_Human0.87954339
70ZNF263_19887448_ChIP-Seq_K562_Human0.87701697
71XRN2_22483619_ChIP-Seq_HELA_Human0.86797518
72ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86269379
73* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86107188
74TP63_17297297_ChIP-ChIP_HaCaT_Human0.85786758
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84072624
76ETS1_22383799_ChIP-Seq_G1ME_Mouse0.83863737
77FOXP3_21729870_ChIP-Seq_TREG_Human0.83350247
78NOTCH1_21737748_ChIP-Seq_TLL_Human0.82681658
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.80986139
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80942095
81* MYC_18940864_ChIP-ChIP_HL60_Human0.79231285
82MYCN_18555785_ChIP-Seq_MESCs_Mouse0.78493246
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.74791567
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73343825
85NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.72849776
86ZFX_18555785_ChIP-Seq_MESCs_Mouse0.72704047
87PKCTHETA_26484144_Chip-Seq_BREAST_Human0.72536908
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72079567
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.71572201
90CIITA_25753668_ChIP-Seq_RAJI_Human0.71370751
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.71220736
92MYB_26560356_Chip-Seq_TH1_Human0.70980150
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.70125370
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.69533841
95CREB1_15753290_ChIP-ChIP_HEK293T_Human0.69310416
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.68381457
97ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.67974960
98NANOG_21062744_ChIP-ChIP_HESCs_Human0.67767055
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.67467101
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.67462976
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.67216155
102GATA2_22383799_ChIP-Seq_G1ME_Mouse0.67038768
103RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.66207504
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.64925735
105RBPJ_22232070_ChIP-Seq_NCS_Mouse0.64744903
106POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.64281882
107KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.64268698
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.64245493
109KDM5A_27292631_Chip-Seq_BREAST_Human0.63805938
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.62511849
111TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.61171679
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.60957051
113SCL_19346495_ChIP-Seq_HPC-7_Human0.60044918
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.59848489
115TCF7_22412390_ChIP-Seq_EML_Mouse0.59500410
116EST1_17652178_ChIP-ChIP_JURKAT_Human0.58704779
117POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.58669188
118UTX_26944678_Chip-Seq_JUKART_Human0.58440539
119MAF_26560356_Chip-Seq_TH1_Human0.58167363
120HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.55998808
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.53429256
122TTF2_22483619_ChIP-Seq_HELA_Human0.53173500

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.84445670
2MP0003111_abnormal_nucleus_morphology4.56240372
3MP0003656_abnormal_erythrocyte_physiolo4.51267620
4MP0004147_increased_porphyrin_level3.93450968
5MP0003077_abnormal_cell_cycle3.74253886
6MP0010307_abnormal_tumor_latency3.70971921
7MP0003693_abnormal_embryo_hatching3.57693201
8MP0004957_abnormal_blastocyst_morpholog3.14681577
9MP0008057_abnormal_DNA_replication3.08620506
10MP0000685_abnormal_immune_system3.04345282
11MP0005645_abnormal_hypothalamus_physiol3.03745811
12MP0010352_gastrointestinal_tract_polyps2.78938067
13MP0003705_abnormal_hypodermis_morpholog2.59336447
14MP0003763_abnormal_thymus_physiology2.46852465
15MP0008058_abnormal_DNA_repair2.46729154
16MP0005076_abnormal_cell_differentiation2.33618666
17MP0000350_abnormal_cell_proliferation2.29050763
18MP0001730_embryonic_growth_arrest2.22239835
19MP0003123_paternal_imprinting2.21903540
20MP0008932_abnormal_embryonic_tissue2.06455262
21MP0003121_genomic_imprinting2.05602462
22MP0008007_abnormal_cellular_replicative1.97164717
23MP0009697_abnormal_copulation1.94817133
24MP0008877_abnormal_DNA_methylation1.93799122
25MP0005671_abnormal_response_to1.89529375
26MP0001835_abnormal_antigen_presentation1.89156514
27MP0002396_abnormal_hematopoietic_system1.79049480
28MP0004808_abnormal_hematopoietic_stem1.78536351
29MP0001661_extended_life_span1.78129759
30MP0002086_abnormal_extraembryonic_tissu1.77102348
31MP0004197_abnormal_fetal_growth/weight/1.74931826
32MP0001697_abnormal_embryo_size1.73966049
33MP0005083_abnormal_biliary_tract1.73848091
34MP0002084_abnormal_developmental_patter1.70415255
35MP0005380_embryogenesis_phenotype1.68661052
36MP0001672_abnormal_embryogenesis/_devel1.68661052
37MP0001800_abnormal_humoral_immune1.67156996
38MP0006054_spinal_hemorrhage1.65318151
39MP0000490_abnormal_crypts_of1.64397233
40MP0002085_abnormal_embryonic_tissue1.63814428
41MP0002080_prenatal_lethality1.55575718
42MP0010234_abnormal_vibrissa_follicle1.54432796
43MP0003984_embryonic_growth_retardation1.47749855
44MP0002088_abnormal_embryonic_growth/wei1.45215472
45MP0002019_abnormal_tumor_incidence1.40652647
46MP0001727_abnormal_embryo_implantation1.38097707
47MP0000313_abnormal_cell_death1.35377228
48MP0001790_abnormal_immune_system1.34024923
49MP0005387_immune_system_phenotype1.34024923
50MP0001545_abnormal_hematopoietic_system1.32765160
51MP0005397_hematopoietic_system_phenotyp1.32765160
52MP0003786_premature_aging1.30955713
53MP0000703_abnormal_thymus_morphology1.27481509
54MP0002009_preneoplasia1.26815576
55MP0000537_abnormal_urethra_morphology1.22690682
56MP0005000_abnormal_immune_tolerance1.20472717
57MP0010030_abnormal_orbit_morphology1.19901234
58MP0006035_abnormal_mitochondrial_morpho1.19411455
59MP0003787_abnormal_imprinting1.18757491
60MP0003937_abnormal_limbs/digits/tail_de1.18474194
61MP0003890_abnormal_embryonic-extraembry1.18428834
62MP0008770_decreased_survivor_rate1.17198073
63MP0000358_abnormal_cell_content/1.16677600
64MP0002722_abnormal_immune_system1.15878211
65MP0002398_abnormal_bone_marrow1.13738172
66MP0000716_abnormal_immune_system1.13605847
67MP0001293_anophthalmia1.13518515
68MP0002111_abnormal_tail_morphology1.09425666
69MP0002420_abnormal_adaptive_immunity1.05222320
70MP0005220_abnormal_exocrine_pancreas1.05054772
71MP0003567_abnormal_fetal_cardiomyocyte1.04284227
72MP0009703_decreased_birth_body1.04033217
73MP0002452_abnormal_antigen_presenting1.04007369
74MP0002092_abnormal_eye_morphology1.03883232
75MP0002163_abnormal_gland_morphology1.03731806
76MP0009278_abnormal_bone_marrow1.02916974
77MP0005451_abnormal_body_composition1.02607895
78MP0000689_abnormal_spleen_morphology1.02387946
79MP0009053_abnormal_anal_canal1.00953802
80MP0001819_abnormal_immune_cell1.00777720
81MP0002697_abnormal_eye_size1.00496625
82MP0000733_abnormal_muscle_development0.99708908
83MP0001915_intracranial_hemorrhage0.99242758
84MP0003566_abnormal_cell_adhesion0.97427103
85MP0002166_altered_tumor_susceptibility0.96277234
86MP0009672_abnormal_birth_weight0.95032567
87MP0002723_abnormal_immune_serum0.93766048
88MP0005310_abnormal_salivary_gland0.93225657
89MP0003283_abnormal_digestive_organ0.93137291
90MP0004264_abnormal_extraembryonic_tissu0.91798356
91MP0002138_abnormal_hepatobiliary_system0.90212244
92MP0003183_abnormal_peptide_metabolism0.90153507
93MP0005623_abnormal_meninges_morphology0.89663408
94MP0003119_abnormal_digestive_system0.87177706
95MP0002925_abnormal_cardiovascular_devel0.87166866
96MP0005501_abnormal_skin_physiology0.86121239
97MP0005621_abnormal_cell_physiology0.85372453
98MP0003941_abnormal_skin_development0.85301216
99MP0003300_gastrointestinal_ulcer0.85122720
100MP0001849_ear_inflammation0.82831958
101MP0005384_cellular_phenotype0.81613775
102MP0003718_maternal_effect0.81285028
103MP0002429_abnormal_blood_cell0.79366070
104MP0002006_tumorigenesis0.78957631
105MP0001346_abnormal_lacrimal_gland0.76028909
106MP0004233_abnormal_muscle_weight0.75710180
107MP0002210_abnormal_sex_determination0.71463002
108MP0003861_abnormal_nervous_system0.71296095
109MP0003115_abnormal_respiratory_system0.71182432
110MP0010678_abnormal_skin_adnexa0.70992274
111MP0000432_abnormal_head_morphology0.70752979
112MP0001873_stomach_inflammation0.70274746
113MP0005023_abnormal_wound_healing0.69827706
114MP0001145_abnormal_male_reproductive0.69582916
115MP0000266_abnormal_heart_morphology0.69495849
116MP0001286_abnormal_eye_development0.69100768
117MP0001348_abnormal_lacrimal_gland0.67299820
118MP0009931_abnormal_skin_appearance0.67221137
119MP0004185_abnormal_adipocyte_glucose0.66835803
120MP0001929_abnormal_gametogenesis0.66772366
121MP0000428_abnormal_craniofacial_morphol0.66763048
122MP0004947_skin_inflammation0.66319669
123MP0002877_abnormal_melanocyte_morpholog0.65364963
124MP0009046_muscle_twitch0.65030755
125MP0009333_abnormal_splenocyte_physiolog0.64604510
126MP0000015_abnormal_ear_pigmentation0.63793079
127MP0000477_abnormal_intestine_morphology0.63284049
128MP0001191_abnormal_skin_condition0.62940491
129MP0003935_abnormal_craniofacial_develop0.61251553
130MP0010155_abnormal_intestine_physiology0.59459284
131MP0003453_abnormal_keratinocyte_physiol0.59099756
132MP0001784_abnormal_fluid_regulation0.58668161
133MP0003303_peritoneal_inflammation0.57888488
134MP0003699_abnormal_female_reproductive0.57515782
135MP0002083_premature_death0.55974247
136MP0003221_abnormal_cardiomyocyte_apopto0.55683462
137MP0000653_abnormal_sex_gland0.55671722
138MP0002095_abnormal_skin_pigmentation0.55614797
139MP0002160_abnormal_reproductive_system0.55280311
140MP0005025_abnormal_response_to0.55050329
141MP0000383_abnormal_hair_follicle0.53907594

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)7.16192366
2IgM deficiency (HP:0002850)6.27118092
3IgA deficiency (HP:0002720)6.07586745
4Gastrointestinal stroma tumor (HP:0100723)5.21143093
5Abnormality of the heme biosynthetic pathway (HP:0010472)5.10568613
6Acanthocytosis (HP:0001927)4.86846415
7Hypochromic microcytic anemia (HP:0004840)4.72457003
8Reticulocytosis (HP:0001923)4.37863024
9Colitis (HP:0002583)4.20926022
10Abnormality of reticulocytes (HP:0004312)3.92324217
11Recurrent sinusitis (HP:0011108)3.77514059
12Chromsome breakage (HP:0040012)3.74407371
13Agammaglobulinemia (HP:0004432)3.71247697
14Cellulitis (HP:0100658)3.71161305
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.68921958
16Abnormality of chromosome stability (HP:0003220)3.28623590
17Lymphopenia (HP:0001888)3.27032523
18Impulsivity (HP:0100710)3.24950817
19Recurrent bronchitis (HP:0002837)3.20762452
20Abnormality of cells of the lymphoid lineage (HP:0012140)3.19479386
21Dry hair (HP:0011359)3.15141612
22Reticulocytopenia (HP:0001896)3.11366338
23Ependymoma (HP:0002888)3.11069887
24Volvulus (HP:0002580)2.92225894
25Microvesicular hepatic steatosis (HP:0001414)2.90637339
26Insomnia (HP:0100785)2.89384668
27Onycholysis (HP:0001806)2.87387800
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.85647585
29Short 4th metacarpal (HP:0010044)2.85647585
30Medulloblastoma (HP:0002885)2.85269645
31Birth length less than 3rd percentile (HP:0003561)2.85162127
32Selective tooth agenesis (HP:0001592)2.78422539
33Cholelithiasis (HP:0001081)2.67219449
34Osteomalacia (HP:0002749)2.64540274
35Astrocytoma (HP:0009592)2.62083062
36Abnormality of the astrocytes (HP:0100707)2.62083062
37Chronic diarrhea (HP:0002028)2.58359096
38B lymphocytopenia (HP:0010976)2.57335517
39Cafe-au-lait spot (HP:0000957)2.56381444
40Cholecystitis (HP:0001082)2.56289200
41Abnormal gallbladder physiology (HP:0012438)2.56289200
42Abnormality of the fingertips (HP:0001211)2.56170821
43High pitched voice (HP:0001620)2.55802273
44Lymphoma (HP:0002665)2.54947027
45Basal cell carcinoma (HP:0002671)2.52924673
46Inflammation of the large intestine (HP:0002037)2.52202297
47Erythema (HP:0010783)2.50403729
48Hypochromic anemia (HP:0001931)2.49962157
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.48436160
50Prominent nose (HP:0000448)2.47688599
51Ridged nail (HP:0001807)2.46804854
52Emphysema (HP:0002097)2.46399516
53Increased nuchal translucency (HP:0010880)2.46277756
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.45919200
55Duodenal stenosis (HP:0100867)2.44162296
56Small intestinal stenosis (HP:0012848)2.44162296
57Meningitis (HP:0001287)2.43879846
58Meckel diverticulum (HP:0002245)2.43558530
59Abnormality of cells of the erythroid lineage (HP:0012130)2.43236828
60Gastrointestinal inflammation (HP:0004386)2.42441842
61Colon cancer (HP:0003003)2.42181607
62Leukopenia (HP:0001882)2.41897553
63Abnormality of the labia minora (HP:0012880)2.41456207
64Recurrent viral infections (HP:0004429)2.38291126
65Rhabdomyosarcoma (HP:0002859)2.37008947
66Abnormality of the ileum (HP:0001549)2.31885303
67Glioma (HP:0009733)2.31510599
68Paralysis (HP:0003470)2.31209396
69Osteomyelitis (HP:0002754)2.30376289
70Abnormality of T cell physiology (HP:0011840)2.28833745
71Sandal gap (HP:0001852)2.27977776
72Cortical dysplasia (HP:0002539)2.26731597
73Agnosia (HP:0010524)2.26700249
74Abnormal gallbladder morphology (HP:0012437)2.25973248
75Deviation of the thumb (HP:0009603)2.24462065
76Neoplasm of the oral cavity (HP:0100649)2.23318692
77Abnormality of the preputium (HP:0100587)2.23062263
78Heterotopia (HP:0002282)2.21877196
79IgG deficiency (HP:0004315)2.21477235
80Cutaneous melanoma (HP:0012056)2.21357691
81Abnormality of DNA repair (HP:0003254)2.19112100
82Myelodysplasia (HP:0002863)2.19002984
83Patellar aplasia (HP:0006443)2.18033895
84Proximal placement of thumb (HP:0009623)2.16223601
85Ulnar bowing (HP:0003031)2.15701209
86Recurrent pneumonia (HP:0006532)2.15177571
87Orthostatic hypotension (HP:0001278)2.13274562
88Abnormal number of erythroid precursors (HP:0012131)2.11987813
89Clubbing of toes (HP:0100760)2.11390946
90Ectopic kidney (HP:0000086)2.10309838
91Abnormality of B cell number (HP:0010975)2.08674579
92Hepatitis (HP:0012115)2.07812304
93Abnormality of the duodenum (HP:0002246)2.07462741
94Autoimmune hemolytic anemia (HP:0001890)2.06995245
95Biliary tract neoplasm (HP:0100574)2.06883381
96Abnormality of the carotid arteries (HP:0005344)2.06838929
97Sparse scalp hair (HP:0002209)2.06616710
98Sloping forehead (HP:0000340)2.03878944
99Recurrent lower respiratory tract infections (HP:0002783)2.03700623
100Squamous cell carcinoma (HP:0002860)2.02859076
101Malignant gastrointestinal tract tumors (HP:0006749)2.02498794
102Gastrointestinal carcinoma (HP:0002672)2.02498794
10311 pairs of ribs (HP:0000878)2.02256009
104Viral hepatitis (HP:0006562)2.01202745
105Entropion (HP:0000621)2.00526717
106Acute lymphatic leukemia (HP:0006721)2.00453937
107Prostate neoplasm (HP:0100787)2.00435689
108Progressive muscle weakness (HP:0003323)1.98949803
109Urticaria (HP:0001025)1.96446779
110Aplasia/Hypoplasia of the patella (HP:0006498)1.96325684
111Abnormal number of incisors (HP:0011064)1.95898050
112Long eyelashes (HP:0000527)1.95174344
113Macrocytic anemia (HP:0001972)1.94900046
114Poikiloderma (HP:0001029)1.93983896
115Neoplasm of striated muscle (HP:0009728)1.92467476
116Missing ribs (HP:0000921)1.91394933
117Septate vagina (HP:0001153)1.91094034
118Hypergonadotropic hypogonadism (HP:0000815)1.91093758
119Absent thumb (HP:0009777)1.90501535
120Hypopigmentation of the fundus (HP:0007894)1.90110499
121Renovascular hypertension (HP:0100817)1.89230810
122Abnormality of the prostate (HP:0008775)1.88721459
123Abnormality of the 4th metacarpal (HP:0010012)1.88419335
124Abnormality of pyrimidine metabolism (HP:0004353)1.86930424
125Hyperbilirubinemia (HP:0002904)1.86892036
126Diaphragmatic weakness (HP:0009113)1.86767839
127Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86446240
128Vasculitis (HP:0002633)1.85270534
129Truncal obesity (HP:0001956)1.85157730
130Nephroblastoma (Wilms tumor) (HP:0002667)1.84828774
131Atresia of the external auditory canal (HP:0000413)1.83751141
132Lower limb hyperreflexia (HP:0002395)1.82630883
133Absent radius (HP:0003974)1.81862387
134Microtia (HP:0008551)1.81197223
135Abnormality of cochlea (HP:0000375)1.81054380
136Aplasia/Hypoplasia of the sternum (HP:0006714)1.79960497
137Eczematoid dermatitis (HP:0000976)1.78566395
138Progressive external ophthalmoplegia (HP:0000590)1.78552689
139Abnormality of chromosome segregation (HP:0002916)1.78372939
140Neoplasm of the pancreas (HP:0002894)1.78345922
141Cutaneous photosensitivity (HP:0000992)1.77597419
142Absent frontal sinuses (HP:0002688)1.76537558
143Mediastinal lymphadenopathy (HP:0100721)1.75699877
144Short thumb (HP:0009778)1.74204811
145Panhypogammaglobulinemia (HP:0003139)1.73874022
146Thyroiditis (HP:0100646)1.72268432
147Abnormal lung lobation (HP:0002101)1.71682928
148Ureteral duplication (HP:0000073)1.71537250
149Renal duplication (HP:0000075)1.71468645
150Leiomyosarcoma (HP:0100243)1.69400180
151Uterine leiomyosarcoma (HP:0002891)1.69400180
152Cerebral aneurysm (HP:0004944)1.69313750
153Breast hypoplasia (HP:0003187)1.69118141
154Elfin facies (HP:0004428)1.69091344
155Duplicated collecting system (HP:0000081)1.68974456
156Pallor (HP:0000980)1.68627736
157Embryonal renal neoplasm (HP:0011794)1.68543936
158Ovarian neoplasm (HP:0100615)1.66931915
159Recurrent bacterial skin infections (HP:0005406)1.66709791
160Hyperacusis (HP:0010780)1.66699578
161Verrucae (HP:0200043)1.66199463
162Papilloma (HP:0012740)1.66199463
163Absent forearm bone (HP:0003953)1.65790998
164Aplasia involving forearm bones (HP:0009822)1.65790998
165Spastic diplegia (HP:0001264)1.65221175
166Deep palmar crease (HP:0006191)1.65009076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.95447674
2ZAK6.16911625
3STK43.64716808
4CDC73.63273271
5VRK13.31297678
6CDK122.56084094
7MAP3K102.37285369
8CDK92.19552590
9NEK22.18399246
10EEF2K2.18128815
11SMG12.03010856
12* RPS6KA52.00804238
13AURKB1.76694023
14MAP3K81.75188153
15SCYL21.72143596
16CHEK21.70641228
17PIM11.65301483
18EIF2AK11.64752574
19WEE11.62335827
20BUB11.55652731
21PKN21.50041906
22TTK1.45939348
23RPS6KB21.43829195
24SRPK11.40103646
25DYRK31.26743506
26TAF11.23735505
27ATR1.15619536
28PLK11.14793344
29GRK61.14502243
30EPHA21.09323221
31DAPK31.04380875
32AURKA1.03986265
33CDK41.03400404
34STK101.02068037
35BRD40.97889788
36PKN10.96432807
37TTN0.93166598
38CHEK10.89185458
39CAMK1D0.88326629
40NEK10.85333237
41ATM0.82229269
42PASK0.80838500
43MELK0.79072709
44BRAF0.78099612
45PRPF4B0.75693748
46ACVR1B0.75042470
47ICK0.74684449
48CCNB10.74124535
49IRAK40.73805881
50PLK30.73391709
51BCKDK0.71348317
52DYRK1B0.70848612
53CDK20.70397865
54CDK60.69817906
55FLT30.69766126
56NME20.68649947
57BRSK10.68328455
58BTK0.64215008
59AKT20.63393755
60CDK70.63362288
61BRSK20.59275941
62NEK90.58963413
63CDK10.56968548
64CDK80.56843273
65PRKAA10.55544894
66STK30.55542010
67PIM20.52487860
68CSNK1D0.51192723
69CLK10.48351089
70SYK0.47665737
71MTOR0.45653642
72LRRK20.44944905
73BLK0.41721809
74TGFBR10.36461706
75TRPM70.36017701
76PRKDC0.35625789
77KDR0.34242519
78VRK20.34174592
79RAF10.33931352
80TRIB30.33864982
81STK160.33435142
82EIF2AK30.32567336
83ARAF0.31616041
84EIF2AK20.30658754
85PAK10.30525150
86MAPK140.30219858
87PLK40.30209659
88MST40.29848527
89MAP4K10.29846440
90LATS10.29118790
91ALK0.29054598
92RPS6KA40.28695153
93MAPKAPK50.28255419
94AKT10.27760151
95MAPKAPK30.26434280
96LYN0.25541664
97MAP3K140.25512528
98ROCK10.24977436
99JAK20.24519715
100MAPK110.23940780
101FRK0.23414387
102PTK60.21923756
103CSNK1G30.21737850
104FGR0.21414414
105PAK40.20343721
106CSNK1A1L0.19762935
107CAMK40.19526483
108ERBB20.19354482
109IRAK30.19290064
110PRKCQ0.19284386
111MKNK10.19257082
112CSNK2A20.19205755
113RPS6KB10.18825647
114MAP2K70.18286750
115SGK10.17666306
116FGFR20.17377869
117RPS6KL10.17346837
118RPS6KC10.17346837
119TSSK60.17282693
120PAK20.17183433
121MAP2K30.16878700
122BMX0.16515310
123PBK0.16468685
124TBK10.16383073
125CAMK1G0.15896745
126PDGFRA0.15665425
127RPS6KA30.15617526
128KSR10.15393591
129GSK3B0.15071892
130TESK20.14775226
131SGK30.14282903
132CSNK1G10.14088705
133IKBKB0.12484482
134PRKCD0.11420362
135CDK150.08913454
136MAP2K20.06970877
137CDK11A0.06363336
138KSR20.06172055

Predicted pathways (KEGG)

RankGene SetZ-score
1* Alcoholism_Homo sapiens_hsa050346.50010378
2Viral carcinogenesis_Homo sapiens_hsa052033.36844225
3DNA replication_Homo sapiens_hsa030302.99933454
4Mismatch repair_Homo sapiens_hsa034302.55880079
5Cell cycle_Homo sapiens_hsa041102.14284352
6* Systemic lupus erythematosus_Homo sapiens_hsa0532211.4171633
7Transcriptional misregulation in cancer_Homo sapiens_hsa052021.93347493
8One carbon pool by folate_Homo sapiens_hsa006701.83114093
9Fanconi anemia pathway_Homo sapiens_hsa034601.63194333
10Nucleotide excision repair_Homo sapiens_hsa034201.56708508
11Base excision repair_Homo sapiens_hsa034101.54924580
12Homologous recombination_Homo sapiens_hsa034401.53513930
13Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.52901130
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.52848033
15Non-homologous end-joining_Homo sapiens_hsa034501.50064919
16RNA transport_Homo sapiens_hsa030131.46900182
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46107047
18Spliceosome_Homo sapiens_hsa030401.38046553
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32977584
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32332151
21Asthma_Homo sapiens_hsa053101.27917205
22Allograft rejection_Homo sapiens_hsa053301.26702441
23Autoimmune thyroid disease_Homo sapiens_hsa053201.18235858
24Ribosome_Homo sapiens_hsa030101.15957708
25p53 signaling pathway_Homo sapiens_hsa041151.12346559
26mRNA surveillance pathway_Homo sapiens_hsa030151.08830502
27Graft-versus-host disease_Homo sapiens_hsa053320.97953444
28MicroRNAs in cancer_Homo sapiens_hsa052060.93532216
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86752496
30Type I diabetes mellitus_Homo sapiens_hsa049400.84591792
31Small cell lung cancer_Homo sapiens_hsa052220.80775024
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78655125
33Pyrimidine metabolism_Homo sapiens_hsa002400.73057211
34Oocyte meiosis_Homo sapiens_hsa041140.67973217
35Chronic myeloid leukemia_Homo sapiens_hsa052200.67222712
36HTLV-I infection_Homo sapiens_hsa051660.65665742
37Non-small cell lung cancer_Homo sapiens_hsa052230.64872943
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64435337
39Bladder cancer_Homo sapiens_hsa052190.63483464
40RNA degradation_Homo sapiens_hsa030180.63186845
41Selenocompound metabolism_Homo sapiens_hsa004500.61609861
42Lysine degradation_Homo sapiens_hsa003100.57441860
43Herpes simplex infection_Homo sapiens_hsa051680.55114416
44Vitamin B6 metabolism_Homo sapiens_hsa007500.52524729
45Carbon metabolism_Homo sapiens_hsa012000.51761744
46Leishmaniasis_Homo sapiens_hsa051400.51346241
47Fructose and mannose metabolism_Homo sapiens_hsa000510.48828972
48Epstein-Barr virus infection_Homo sapiens_hsa051690.47625392
49RNA polymerase_Homo sapiens_hsa030200.46255833
50Apoptosis_Homo sapiens_hsa042100.46130868
51mTOR signaling pathway_Homo sapiens_hsa041500.45231118
52Antigen processing and presentation_Homo sapiens_hsa046120.40014051
53Pancreatic cancer_Homo sapiens_hsa052120.39741854
54Hepatitis B_Homo sapiens_hsa051610.39346013
55Prostate cancer_Homo sapiens_hsa052150.38203859
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38071160
57Colorectal cancer_Homo sapiens_hsa052100.37437137
58TGF-beta signaling pathway_Homo sapiens_hsa043500.36754264
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36301071
60Hematopoietic cell lineage_Homo sapiens_hsa046400.36014763
61Glioma_Homo sapiens_hsa052140.35092711
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.33341330
63Basal cell carcinoma_Homo sapiens_hsa052170.32185418
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31707167
65FoxO signaling pathway_Homo sapiens_hsa040680.30442906
66Hippo signaling pathway_Homo sapiens_hsa043900.29833294
67Proteoglycans in cancer_Homo sapiens_hsa052050.29690745
68Basal transcription factors_Homo sapiens_hsa030220.28976575
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28279488
70Thyroid cancer_Homo sapiens_hsa052160.27739615
71Endometrial cancer_Homo sapiens_hsa052130.26134023
72Adherens junction_Homo sapiens_hsa045200.25902112
73Galactose metabolism_Homo sapiens_hsa000520.25581783
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25242811
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25210595
76Notch signaling pathway_Homo sapiens_hsa043300.24687663
77Melanoma_Homo sapiens_hsa052180.24530678
78Biosynthesis of amino acids_Homo sapiens_hsa012300.23766533
79B cell receptor signaling pathway_Homo sapiens_hsa046620.23715417
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.22772689
81N-Glycan biosynthesis_Homo sapiens_hsa005100.22596153
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22458895
83Purine metabolism_Homo sapiens_hsa002300.22403423
84Proteasome_Homo sapiens_hsa030500.22099407
85Measles_Homo sapiens_hsa051620.22031765
86Pathways in cancer_Homo sapiens_hsa052000.21846705
87Sulfur relay system_Homo sapiens_hsa041220.20952862
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20814493
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20449822
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19199532
91AMPK signaling pathway_Homo sapiens_hsa041520.18163178
92Malaria_Homo sapiens_hsa051440.17761695
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17747009
94Pyruvate metabolism_Homo sapiens_hsa006200.17060781
95Tight junction_Homo sapiens_hsa045300.16993552
96HIF-1 signaling pathway_Homo sapiens_hsa040660.16966308
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16901632
98Toxoplasmosis_Homo sapiens_hsa051450.16500282
99Pentose phosphate pathway_Homo sapiens_hsa000300.15930322
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15658185
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.14441576
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.14172493
103Renin-angiotensin system_Homo sapiens_hsa046140.14054712
104Phenylalanine metabolism_Homo sapiens_hsa003600.13603040
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.13243397
106Focal adhesion_Homo sapiens_hsa045100.13072306
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12318472
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11822348
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11685144
110Platelet activation_Homo sapiens_hsa046110.11461548
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11420300
112Influenza A_Homo sapiens_hsa051640.11243920
113Dorso-ventral axis formation_Homo sapiens_hsa043200.11202872
114Inositol phosphate metabolism_Homo sapiens_hsa005620.10613326
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10009355
116Viral myocarditis_Homo sapiens_hsa054160.09863113
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09363576
118ECM-receptor interaction_Homo sapiens_hsa045120.09204174
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08438607
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.07599367
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.07074627
122Acute myeloid leukemia_Homo sapiens_hsa052210.06335558
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.06242837
124ABC transporters_Homo sapiens_hsa020100.06167008
125Primary immunodeficiency_Homo sapiens_hsa053400.05590565
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.05405578
127Legionellosis_Homo sapiens_hsa051340.05194830
128Hedgehog signaling pathway_Homo sapiens_hsa043400.05084435
129Staphylococcus aureus infection_Homo sapiens_hsa051500.04356830
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.04195068
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.02144413
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.02038709
133Arginine biosynthesis_Homo sapiens_hsa002200.01886577

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