HIST1H2AE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mucosal immune response (GO:0002385)9.66754161
2antibacterial humoral response (GO:0019731)9.41014980
3organ or tissue specific immune response (GO:0002251)8.72922956
4antimicrobial humoral response (GO:0019730)8.60586275
5nuclear pore complex assembly (GO:0051292)7.38276068
6ribosomal small subunit assembly (GO:0000028)6.50795268
7negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)5.88927122
8DNA replication-dependent nucleosome assembly (GO:0006335)5.62839543
9DNA replication-dependent nucleosome organization (GO:0034723)5.62839543
10pore complex assembly (GO:0046931)5.58546643
11telomere maintenance via semi-conservative replication (GO:0032201)5.46287418
12DNA strand elongation involved in DNA replication (GO:0006271)5.43475596
13CENP-A containing nucleosome assembly (GO:0034080)5.30989788
14viral transcription (GO:0019083)5.30952967
15chromatin remodeling at centromere (GO:0031055)5.20844317
16DNA strand elongation (GO:0022616)5.18526476
17translational termination (GO:0006415)5.15730212
18ribosomal small subunit biogenesis (GO:0042274)5.09602315
19maturation of SSU-rRNA (GO:0030490)4.93594646
20telomere maintenance via recombination (GO:0000722)4.82209677
21kinetochore organization (GO:0051383)4.79434680
22DNA deamination (GO:0045006)4.79224918
23DNA replication initiation (GO:0006270)4.78447077
24protein localization to kinetochore (GO:0034501)4.74751274
25mitotic recombination (GO:0006312)4.71429857
26DNA unwinding involved in DNA replication (GO:0006268)4.71239876
27regulation of megakaryocyte differentiation (GO:0045652)4.65541376
28DNA replication-independent nucleosome assembly (GO:0006336)4.60428428
29DNA replication-independent nucleosome organization (GO:0034724)4.60428428
30translational elongation (GO:0006414)4.52989460
31mitotic metaphase plate congression (GO:0007080)4.49214539
32attachment of spindle microtubules to kinetochore (GO:0008608)4.42079506
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.33479269
34protein localization to chromosome, centromeric region (GO:0071459)4.33055774
35kinetochore assembly (GO:0051382)4.26311227
36telomere maintenance via telomere lengthening (GO:0010833)4.23837429
37cotranslational protein targeting to membrane (GO:0006613)4.22735877
38ribosomal large subunit biogenesis (GO:0042273)4.22104620
39protein targeting to ER (GO:0045047)4.20444056
40DNA replication checkpoint (GO:0000076)4.18920823
41nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.16717472
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.15187409
43cellular protein complex disassembly (GO:0043624)4.14393137
44chromatin assembly or disassembly (GO:0006333)4.14350913
45mitotic chromosome condensation (GO:0007076)4.12216879
46translational initiation (GO:0006413)4.11417679
47nucleosome assembly (GO:0006334)4.09403755
48histone exchange (GO:0043486)4.09135614
49metaphase plate congression (GO:0051310)4.07523789
50nucleotide-excision repair, DNA gap filling (GO:0006297)4.06945850
51viral life cycle (GO:0019058)3.98679445
52establishment of protein localization to endoplasmic reticulum (GO:0072599)3.98591032
53mitotic sister chromatid segregation (GO:0000070)3.96298380
54protein localization to endoplasmic reticulum (GO:0070972)3.93971052
55meiotic chromosome segregation (GO:0045132)3.89985612
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.83296272
57protein complex disassembly (GO:0043241)3.81930044
58defense response to Gram-positive bacterium (GO:0050830)3.80486113
59sister chromatid segregation (GO:0000819)3.75293625
60regulation of centrosome cycle (GO:0046605)3.73292143
61peptidyl-lysine dimethylation (GO:0018027)3.71924839
62protein-DNA complex assembly (GO:0065004)3.68773994
63regulation of histone H3-K9 methylation (GO:0051570)3.66795328
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.65239372
65establishment of chromosome localization (GO:0051303)3.60249500
66macromolecular complex disassembly (GO:0032984)3.59035822
67regulation of gene silencing (GO:0060968)3.57984118
68nucleobase biosynthetic process (GO:0046112)3.57194924
69ribonucleoprotein complex biogenesis (GO:0022613)3.56022764
70nucleosome organization (GO:0034728)3.55789795
71chromatin assembly (GO:0031497)3.54078511
72replicative senescence (GO:0090399)3.51533620
73V(D)J recombination (GO:0033151)3.49909439
74non-recombinational repair (GO:0000726)3.41585131
75double-strand break repair via nonhomologous end joining (GO:0006303)3.41585131
76regulation of centrosome duplication (GO:0010824)3.40730523
77telomere maintenance (GO:0000723)3.37926908
78telomere organization (GO:0032200)3.36649442
79nuclear-transcribed mRNA catabolic process (GO:0000956)3.35262748
80purine nucleobase biosynthetic process (GO:0009113)3.32034077
81histone lysine demethylation (GO:0070076)3.32012372
82rRNA processing (GO:0006364)3.31293102
83protein-DNA complex subunit organization (GO:0071824)3.29636713
84mitotic nuclear envelope disassembly (GO:0007077)3.28781167
85folic acid-containing compound biosynthetic process (GO:0009396)3.27145118
86negative regulation of DNA repair (GO:0045738)3.24990620
87translation (GO:0006412)3.24137828
88IMP biosynthetic process (GO:0006188)3.24077080
89mRNA catabolic process (GO:0006402)3.22093421
90spliceosomal snRNP assembly (GO:0000387)3.20847824
91DNA topological change (GO:0006265)3.19341021
92rRNA metabolic process (GO:0016072)3.18545662
93translesion synthesis (GO:0019985)3.18067936
94histone demethylation (GO:0016577)3.17694965
95spliceosomal complex assembly (GO:0000245)3.17470469
96deoxyribonucleotide biosynthetic process (GO:0009263)3.17009092
97protein K6-linked ubiquitination (GO:0085020)3.16562021
98microtubule depolymerization (GO:0007019)3.15798140
99RNA catabolic process (GO:0006401)3.14274818
100mitotic sister chromatid cohesion (GO:0007064)3.13853188
101regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.13473294
102establishment of integrated proviral latency (GO:0075713)3.12761907
103somatic diversification of immune receptors via somatic mutation (GO:0002566)3.11783891
104somatic hypermutation of immunoglobulin genes (GO:0016446)3.11783891
105positive regulation of histone methylation (GO:0031062)3.11192751
106regulation of centriole replication (GO:0046599)3.11138918
107formation of translation preinitiation complex (GO:0001731)3.09945036
108B cell receptor signaling pathway (GO:0050853)3.09408387
109ATP-dependent chromatin remodeling (GO:0043044)3.06539927
110viral mRNA export from host cell nucleus (GO:0046784)3.05716331
111proteasome assembly (GO:0043248)3.04395614
112transcription-coupled nucleotide-excision repair (GO:0006283)3.03094473
113regulation of chromosome segregation (GO:0051983)3.02716194
114DNA duplex unwinding (GO:0032508)3.01264349
115nuclear envelope disassembly (GO:0051081)3.00961349
116membrane disassembly (GO:0030397)3.00961349
117DNA geometric change (GO:0032392)3.00947343
118DNA ligation (GO:0006266)3.00723795
119protein localization to chromosome (GO:0034502)3.00530262
120chromosome segregation (GO:0007059)3.00405743
121regulation of hematopoietic progenitor cell differentiation (GO:1901532)3.00092676
122regulation of sister chromatid cohesion (GO:0007063)3.00004999
123regulation of nuclear cell cycle DNA replication (GO:0033262)2.98450003
124positive regulation of chromosome segregation (GO:0051984)2.98418402
125DNA conformation change (GO:0071103)2.95299448
126positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.94634271
127positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.94634271
128positive regulation of mitotic sister chromatid separation (GO:1901970)2.94634271
129spindle checkpoint (GO:0031577)2.94343510
130mismatch repair (GO:0006298)2.93895011
131nuclear pore organization (GO:0006999)2.91980247
132maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91263186
133negative regulation of chromosome segregation (GO:0051985)2.90918736
134spindle assembly checkpoint (GO:0071173)2.87299722
135regulation of mitotic sister chromatid separation (GO:0010965)2.86897632
136regulation of mitotic sister chromatid segregation (GO:0033047)2.86897632
137regulation of sister chromatid segregation (GO:0033045)2.86897632
138regulation of spindle organization (GO:0090224)2.86741767
139DNA synthesis involved in DNA repair (GO:0000731)2.86628218
140regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86457726
141regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86457726
142somatic cell DNA recombination (GO:0016444)2.85436983
143somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.85436983
144pre-miRNA processing (GO:0031054)2.83456503
145replication fork processing (GO:0031297)2.77058224
146protein dealkylation (GO:0008214)2.76548431
147protein demethylation (GO:0006482)2.76548431
148mature B cell differentiation involved in immune response (GO:0002313)2.74871188
149negative regulation of mitotic sister chromatid separation (GO:2000816)2.74616426
150negative regulation of sister chromatid segregation (GO:0033046)2.74616426
151negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74616426
152negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74616426
153negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74616426
154mitotic spindle assembly checkpoint (GO:0007094)2.74407322
155innate immune response in mucosa (GO:0002227)11.7926605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.01107586
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.59687248
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.67069721
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.42082901
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.77778511
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.62307846
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.44400363
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.00772829
9POU5F1_16153702_ChIP-ChIP_HESCs_Human2.68533413
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67225545
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62637825
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.61400603
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56339390
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55574417
15* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.35501545
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32108640
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30602252
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.29955028
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28635764
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24909030
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.23876579
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.22483544
23* VDR_23849224_ChIP-Seq_CD4+_Human2.18052738
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17527350
25* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.12893684
26XRN2_22483619_ChIP-Seq_HELA_Human2.08933433
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94525181
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87546631
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87418287
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86614549
31FOXP3_21729870_ChIP-Seq_TREG_Human1.85268720
32AR_21909140_ChIP-Seq_LNCAP_Human1.82808009
33GATA1_22025678_ChIP-Seq_K562_Human1.81581612
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.80706494
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80554197
36* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79106357
37* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78785681
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74160058
39IRF1_19129219_ChIP-ChIP_H3396_Human1.71515799
40* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69705654
41DCP1A_22483619_ChIP-Seq_HELA_Human1.68316163
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62501455
43* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60686478
44TTF2_22483619_ChIP-Seq_HELA_Human1.60278647
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.59908757
46ELK1_19687146_ChIP-ChIP_HELA_Human1.58663790
47* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51773705
48* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.50138072
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49414729
50* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48543816
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48164520
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46268567
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46221715
54CIITA_25753668_ChIP-Seq_RAJI_Human1.45016957
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43396234
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40122930
57GABP_19822575_ChIP-Seq_HepG2_Human1.39593425
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39409712
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35751292
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33094812
61* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31006739
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.30683459
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.30033596
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28265438
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26263353
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25771421
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23330492
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23170149
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22772384
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21860542
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.21244144
72MYC_22102868_ChIP-Seq_BL_Human1.18006325
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15381487
74* SOX2_16153702_ChIP-ChIP_HESCs_Human1.13789546
75ETS1_22383799_ChIP-Seq_G1ME_Mouse1.13424294
76MYC_18940864_ChIP-ChIP_HL60_Human1.13387787
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12758545
78* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11279024
79VDR_21846776_ChIP-Seq_THP-1_Human1.11095329
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06159286
81* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05411303
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05360216
83* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04207009
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03646516
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03439825
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00606135
87KDM5A_27292631_Chip-Seq_BREAST_Human1.00469897
88* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96950915
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96806309
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95578442
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.94359106
92* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93511546
93ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91098620
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90808634
95STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90627334
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90539611
97SCL_19346495_ChIP-Seq_HPC-7_Human0.86937592
98SPI1_23547873_ChIP-Seq_NB4_Human0.86323964
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85503084
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83192008
101* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82842227
102KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82764194
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82639735
104GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82572040
105PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82361999
106* NANOG_16153702_ChIP-ChIP_HESCs_Human0.82273873
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80796282
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80207361
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78913258
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.78440902
111TFEB_21752829_ChIP-Seq_HELA_Human0.77984559
112TCF3_18692474_ChIP-Seq_MESCs_Mouse0.76766581
113GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76073455
114SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74417557
115MAF_26560356_Chip-Seq_TH1_Human0.71206023
116PKCTHETA_26484144_Chip-Seq_BREAST_Human0.70645753
117* SALL4_22934838_ChIP-ChIP_CD34+_Human0.63534831
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.63446316
119MYB_26560356_Chip-Seq_TH1_Human0.60279733
120* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.55133349
121* SOX9_26525672_Chip-Seq_HEART_Mouse0.53702472
122PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.45202778
123ZNF263_19887448_ChIP-Seq_K562_Human0.44469550
124POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.42772067
125POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.42662271

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.79011554
2MP0010094_abnormal_chromosome_stability5.28645375
3MP0003111_abnormal_nucleus_morphology4.73398583
4MP0004957_abnormal_blastocyst_morpholog4.28836361
5MP0003077_abnormal_cell_cycle4.17489805
6MP0008057_abnormal_DNA_replication3.86062254
7MP0008058_abnormal_DNA_repair3.68269777
8MP0002009_preneoplasia3.64439821
9MP0002396_abnormal_hematopoietic_system3.06068423
10MP0005645_abnormal_hypothalamus_physiol2.80653953
11MP0008007_abnormal_cellular_replicative2.80116082
12MP0008932_abnormal_embryonic_tissue2.69325404
13MP0009697_abnormal_copulation2.53761767
14MP0004147_increased_porphyrin_level2.49965552
15MP0000490_abnormal_crypts_of2.20767324
16MP0003656_abnormal_erythrocyte_physiolo2.20563030
17MP0009379_abnormal_foot_pigmentation2.12370715
18MP0003123_paternal_imprinting2.01698263
19MP0000350_abnormal_cell_proliferation1.93562973
20MP0010307_abnormal_tumor_latency1.91253573
21MP0003786_premature_aging1.90978585
22MP0005083_abnormal_biliary_tract1.90949475
23MP0008877_abnormal_DNA_methylation1.89864209
24MP0004808_abnormal_hematopoietic_stem1.84901573
25MP0000569_abnormal_digit_pigmentation1.78984807
26MP0001730_embryonic_growth_arrest1.78549285
27MP0010234_abnormal_vibrissa_follicle1.78275393
28MP0001545_abnormal_hematopoietic_system1.69046084
29MP0005397_hematopoietic_system_phenotyp1.69046084
30MP0001661_extended_life_span1.61458815
31MP0006054_spinal_hemorrhage1.58513046
32MP0000313_abnormal_cell_death1.56295339
33MP0002019_abnormal_tumor_incidence1.56227649
34MP0005623_abnormal_meninges_morphology1.53056283
35MP0002398_abnormal_bone_marrow1.47837069
36MP0000703_abnormal_thymus_morphology1.43688998
37MP0003763_abnormal_thymus_physiology1.42810375
38MP0002722_abnormal_immune_system1.41263863
39MP0001697_abnormal_embryo_size1.38085453
40MP0002080_prenatal_lethality1.36398525
41MP0003806_abnormal_nucleotide_metabolis1.35994466
42MP0005174_abnormal_tail_pigmentation1.34838937
43MP0005075_abnormal_melanosome_morpholog1.34073041
44MP0002102_abnormal_ear_morphology1.33602230
45MP0009333_abnormal_splenocyte_physiolog1.33159142
46MP0001672_abnormal_embryogenesis/_devel1.33000887
47MP0005380_embryogenesis_phenotype1.33000887
48MP0000689_abnormal_spleen_morphology1.31900851
49MP0010352_gastrointestinal_tract_polyps1.31256590
50MP0002095_abnormal_skin_pigmentation1.30277970
51MP0000537_abnormal_urethra_morphology1.30252830
52MP0006035_abnormal_mitochondrial_morpho1.23580658
53MP0003186_abnormal_redox_activity1.21770084
54MP0002132_abnormal_respiratory_system1.20249166
55MP0002085_abnormal_embryonic_tissue1.18040343
56MP0002429_abnormal_blood_cell1.16542837
57MP0002086_abnormal_extraembryonic_tissu1.15519181
58MP0003984_embryonic_growth_retardation1.14093381
59MP0002088_abnormal_embryonic_growth/wei1.09873711
60MP0002697_abnormal_eye_size1.09644258
61MP0001835_abnormal_antigen_presentation1.05798685
62MP0003121_genomic_imprinting1.05468550
63MP0005220_abnormal_exocrine_pancreas1.05392553
64MP0004381_abnormal_hair_follicle1.03749838
65MP0006036_abnormal_mitochondrial_physio1.02780478
66MP0001293_anophthalmia1.02217929
67MP0002877_abnormal_melanocyte_morpholog1.01574247
68MP0000716_abnormal_immune_system1.00453258
69MP0003718_maternal_effect0.99977242
70MP0002638_abnormal_pupillary_reflex0.99454655
71MP0001853_heart_inflammation0.99071165
72MP0002210_abnormal_sex_determination0.99065663
73MP0003315_abnormal_perineum_morphology0.97904613
74MP0003941_abnormal_skin_development0.97472575
75MP0006292_abnormal_olfactory_placode0.97211963
76MP0006072_abnormal_retinal_apoptosis0.96712277
77MP0003567_abnormal_fetal_cardiomyocyte0.94569692
78MP0002084_abnormal_developmental_patter0.94013546
79MP0005671_abnormal_response_to0.91217280
80MP0004197_abnormal_fetal_growth/weight/0.90627764
81MP0000858_altered_metastatic_potential0.88582400
82MP0003136_yellow_coat_color0.88440063
83MP0003183_abnormal_peptide_metabolism0.88265473
84MP0000465_gastrointestinal_hemorrhage0.87960927
85MP0001800_abnormal_humoral_immune0.87043537
86MP0001145_abnormal_male_reproductive0.86609817
87MP0002420_abnormal_adaptive_immunity0.85507655
88MP0002092_abnormal_eye_morphology0.84879460
89MP0001915_intracranial_hemorrhage0.83844855
90MP0003937_abnormal_limbs/digits/tail_de0.83603293
91MP0000015_abnormal_ear_pigmentation0.83509949
92MP0001819_abnormal_immune_cell0.83301013
93MP0001929_abnormal_gametogenesis0.81851442
94MP0002138_abnormal_hepatobiliary_system0.81807507
95MP0001849_ear_inflammation0.80621501
96MP0010678_abnormal_skin_adnexa0.80468711
97MP0000685_abnormal_immune_system0.80453182
98MP0005647_abnormal_sex_gland0.79055116
99MP0002166_altered_tumor_susceptibility0.78714114
100MP0002452_abnormal_antigen_presenting0.78325268
101MP0001727_abnormal_embryo_implantation0.77133592
102MP0000372_irregular_coat_pigmentation0.76246776
103MP0001879_abnormal_lymphatic_vessel0.75426288
104MP0003221_abnormal_cardiomyocyte_apopto0.74999958
105MP0002822_catalepsy0.73854608
106MP0002006_tumorigenesis0.73748951
107MP0000653_abnormal_sex_gland0.73743994
108MP0000428_abnormal_craniofacial_morphol0.72347549
109MP0005000_abnormal_immune_tolerance0.71168231
110MP0000358_abnormal_cell_content/0.70572391
111MP0005391_vision/eye_phenotype0.70059276
112MP0001286_abnormal_eye_development0.69987986
113MP0005253_abnormal_eye_physiology0.68704385
114MP0001119_abnormal_female_reproductive0.67899470
115MP0001790_abnormal_immune_system0.67090098
116MP0005387_immune_system_phenotype0.67090098
117MP0000477_abnormal_intestine_morphology0.66767695
118MP0001348_abnormal_lacrimal_gland0.66328642
119MP0002075_abnormal_coat/hair_pigmentati0.65761255
120MP0002723_abnormal_immune_serum0.65564134
121MP0000371_diluted_coat_color0.65315942
122MP0005384_cellular_phenotype0.65236644
123MP0005389_reproductive_system_phenotype0.64650430
124MP0004185_abnormal_adipocyte_glucose0.64525422
125MP0005025_abnormal_response_to0.64356247
126MP0002111_abnormal_tail_morphology0.63995219
127MP0005076_abnormal_cell_differentiation0.63774862
128MP0003699_abnormal_female_reproductive0.63166334
129MP0002160_abnormal_reproductive_system0.63016484
130MP0009046_muscle_twitch0.62361280
131MP0010155_abnormal_intestine_physiology0.61802089
132MP0005171_absent_coat_pigmentation0.61653607
133MP0001873_stomach_inflammation0.60529697
134MP0000383_abnormal_hair_follicle0.60512685
135MP0002405_respiratory_system_inflammati0.60484347
136MP0009785_altered_susceptibility_to0.58461061
137MP0005621_abnormal_cell_physiology0.58352882
138MP0003890_abnormal_embryonic-extraembry0.57270107
139MP0004133_heterotaxia0.55145180
140MP0010030_abnormal_orbit_morphology0.55064170
141MP0005464_abnormal_platelet_physiology0.54809137

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.40202935
2Reticulocytopenia (HP:0001896)6.34800608
3Abnormal number of erythroid precursors (HP:0012131)6.31552939
4IgA deficiency (HP:0002720)6.07629716
5Chromsome breakage (HP:0040012)4.81916902
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.60663846
7Colitis (HP:0002583)4.50503850
8Birth length less than 3rd percentile (HP:0003561)4.49068717
9Gastrointestinal stroma tumor (HP:0100723)4.09226162
10Macrocytic anemia (HP:0001972)4.09113787
11Abnormality of the heme biosynthetic pathway (HP:0010472)4.06056777
12Pallor (HP:0000980)4.04901392
13Aplastic anemia (HP:0001915)3.95166429
14Recurrent sinusitis (HP:0011108)3.88233277
15Abnormality of chromosome stability (HP:0003220)3.71975626
1611 pairs of ribs (HP:0000878)3.61822514
17Colon cancer (HP:0003003)3.60587629
18Meckel diverticulum (HP:0002245)3.48749650
19Abnormality of the preputium (HP:0100587)3.48305714
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.43510183
21Short 4th metacarpal (HP:0010044)3.43510183
22Breast hypoplasia (HP:0003187)3.40875901
23Oral leukoplakia (HP:0002745)3.34624464
24Abnormality of the ileum (HP:0001549)3.34187140
25Aplasia/Hypoplasia of the sacrum (HP:0008517)3.31440116
26Aplasia/Hypoplasia of the uvula (HP:0010293)3.26334040
27Thrombocytosis (HP:0001894)3.16662022
28Abnormality of reticulocytes (HP:0004312)3.11168715
29Absent thumb (HP:0009777)3.09218516
30Patellar aplasia (HP:0006443)3.04556749
31Cellulitis (HP:0100658)3.04088493
32Lymphopenia (HP:0001888)2.99817494
33Recurrent bronchitis (HP:0002837)2.96613800
34Myelodysplasia (HP:0002863)2.96109319
35Medulloblastoma (HP:0002885)2.93488207
36Agammaglobulinemia (HP:0004432)2.85890515
37Abnormality of cells of the lymphoid lineage (HP:0012140)2.85067053
38Small intestinal stenosis (HP:0012848)2.84291199
39Duodenal stenosis (HP:0100867)2.84291199
40Autoimmune hemolytic anemia (HP:0001890)2.81477826
41Aplasia/Hypoplasia of the patella (HP:0006498)2.78838153
42Squamous cell carcinoma (HP:0002860)2.75631795
43Thyroiditis (HP:0100646)2.74259809
44Carpal bone hypoplasia (HP:0001498)2.74101008
45Bone marrow hypocellularity (HP:0005528)2.71072552
46B lymphocytopenia (HP:0010976)2.69575886
47Poikilocytosis (HP:0004447)2.66776740
48Selective tooth agenesis (HP:0001592)2.62476632
49Abnormality of the fingertips (HP:0001211)2.60255926
50Inflammation of the large intestine (HP:0002037)2.48150384
51Impulsivity (HP:0100710)2.47255313
52Duplicated collecting system (HP:0000081)2.45903099
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.45069628
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.45069628
55Dry hair (HP:0011359)2.44444111
56IgM deficiency (HP:0002850)2.43397072
57Chronic diarrhea (HP:0002028)2.43317572
58Rough bone trabeculation (HP:0100670)2.43259367
59Missing ribs (HP:0000921)2.42913535
60Abnormality of B cell number (HP:0010975)2.42417822
61Abnormal lung lobation (HP:0002101)2.41657789
62Premature graying of hair (HP:0002216)2.40802567
63Triphalangeal thumb (HP:0001199)2.40758660
64Microretrognathia (HP:0000308)2.36209108
65Agnosia (HP:0010524)2.35918850
66Abnormality of the 4th metacarpal (HP:0010012)2.35008568
67Clubbing of toes (HP:0100760)2.34682915
68Sloping forehead (HP:0000340)2.34171583
69Abnormality of the duodenum (HP:0002246)2.33755488
70Premature ovarian failure (HP:0008209)2.30393461
71Orthostatic hypotension (HP:0001278)2.28147689
72Cellular immunodeficiency (HP:0005374)2.28000631
73Cerebral hypomyelination (HP:0006808)2.26794526
74Gastrointestinal inflammation (HP:0004386)2.25364470
75Abnormality of the renal collecting system (HP:0004742)2.24751351
76Absent radius (HP:0003974)2.24063657
77Pancytopenia (HP:0001876)2.23615443
78Erythema (HP:0010783)2.20751862
79Horseshoe kidney (HP:0000085)2.17579502
80Lymphoma (HP:0002665)2.17120260
81Tracheoesophageal fistula (HP:0002575)2.17067208
82Cleft eyelid (HP:0000625)2.16253254
83Neoplasm of striated muscle (HP:0009728)2.15844104
84Secondary amenorrhea (HP:0000869)2.15107541
85Type I transferrin isoform profile (HP:0003642)2.14845718
86Abnormality of the carotid arteries (HP:0005344)2.14802212
87Abnormal number of incisors (HP:0011064)2.13994853
88Asplenia (HP:0001746)2.13449908
89Neoplasm of the oral cavity (HP:0100649)2.13374793
90Down-sloping shoulders (HP:0200021)2.10776698
91Ectopic kidney (HP:0000086)2.10471147
92Neoplasm of the pancreas (HP:0002894)2.09185712
93Renovascular hypertension (HP:0100817)2.08963959
94Short thumb (HP:0009778)2.08168789
95Absent forearm bone (HP:0003953)2.05264044
96Aplasia involving forearm bones (HP:0009822)2.05264044
97Abnormality of pyrimidine metabolism (HP:0004353)2.04677103
98Prostate neoplasm (HP:0100787)2.04159644
99Papillary thyroid carcinoma (HP:0002895)2.03373287
100Increased hepatocellular lipid droplets (HP:0006565)2.02295277
101Neoplasm of the heart (HP:0100544)2.01667955
102Ridged nail (HP:0001807)2.01560551
103Acanthocytosis (HP:0001927)1.98501265
104Abnormality of DNA repair (HP:0003254)1.96218745
105Supernumerary spleens (HP:0009799)1.94795609
106Prominent nose (HP:0000448)1.94577058
107Arteriovenous malformation (HP:0100026)1.94365718
108Viral hepatitis (HP:0006562)1.94324937
109Nephroblastoma (Wilms tumor) (HP:0002667)1.93530001
110Deep philtrum (HP:0002002)1.89480853
111Deep palmar crease (HP:0006191)1.88050338
112Recurrent viral infections (HP:0004429)1.87978733
113Hypoplasia of the radius (HP:0002984)1.87852446
114Aplasia/Hypoplasia of the spleen (HP:0010451)1.87701294
115Microvesicular hepatic steatosis (HP:0001414)1.87698359
116Bronchitis (HP:0012387)1.86467772
117Poikiloderma (HP:0001029)1.86380167
118Sandal gap (HP:0001852)1.85941526
119Petechiae (HP:0000967)1.85664339
120Uterine leiomyosarcoma (HP:0002891)1.85189696
121Leiomyosarcoma (HP:0100243)1.85189696
122Hypoplasia of the pons (HP:0012110)1.83893146
123Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83432620
124Hepatitis (HP:0012115)1.83043106
125Hyperacusis (HP:0010780)1.82891629
126Atresia of the external auditory canal (HP:0000413)1.81860120
127Acute lymphatic leukemia (HP:0006721)1.81688499
128Ependymoma (HP:0002888)1.81662810
129Abnormality of the prostate (HP:0008775)1.81628039
130Trismus (HP:0000211)1.80798804
131Rhabdomyosarcoma (HP:0002859)1.80141213
132Dyschromatopsia (HP:0007641)1.79974737
133Onycholysis (HP:0001806)1.79903255
134Cafe-au-lait spot (HP:0000957)1.79463372
135IgG deficiency (HP:0004315)1.77939871
136Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77359891
137Leukopenia (HP:0001882)1.76689964
138Aplasia/Hypoplasia of the thymus (HP:0010515)1.76157000
139Depressed nasal ridge (HP:0000457)1.75792107
140Increased serum lactate (HP:0002151)1.75438250
141Exertional dyspnea (HP:0002875)1.74809809
142Basal cell carcinoma (HP:0002671)1.74472095
143Embryonal renal neoplasm (HP:0011794)1.74325733
144Multiple enchondromatosis (HP:0005701)1.72604045
145Lipid accumulation in hepatocytes (HP:0006561)1.72356329
146Malignant gastrointestinal tract tumors (HP:0006749)1.72194646
147Gastrointestinal carcinoma (HP:0002672)1.72194646
148Abnormality of the parietal bone (HP:0002696)1.71768129
149Abnormality of the pons (HP:0007361)1.71727053
150Slender long bone (HP:0003100)1.71373791
151Abnormal platelet volume (HP:0011876)1.71254272
152Volvulus (HP:0002580)1.70459583
153Spontaneous hematomas (HP:0007420)1.70260195
154Hypopigmented skin patches (HP:0001053)1.70014015
155Recurrent pneumonia (HP:0006532)1.69368927
156Combined immunodeficiency (HP:0005387)1.68630717
157Amaurosis fugax (HP:0100576)1.68437429
158Increased mean platelet volume (HP:0011877)1.67975423
159Osteomyelitis (HP:0002754)1.67556309
160Emphysema (HP:0002097)1.66433364
161Subacute progressive viral hepatitis (HP:0006572)1.63943000
162Chronic hepatic failure (HP:0100626)1.62645959
163Panhypogammaglobulinemia (HP:0003139)1.62535790
164Hemivertebrae (HP:0002937)1.61102325

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.77113617
2VRK13.73744869
3WEE13.66770237
4ZAK3.63608341
5CDC73.38663757
6BUB13.38631844
7NEK23.03620880
8EIF2AK12.97246084
9NEK12.81505586
10STK42.46886267
11BRSK22.42899610
12NME22.40524184
13PLK42.28843634
14CCNB12.25759057
15SRPK12.22345709
16STK162.17355216
17AURKB2.01921201
18ACVR1B1.94435365
19RPS6KA51.84871517
20TTK1.80188097
21PLK11.73305516
22BRSK11.59682422
23RPS6KB21.52755052
24SCYL21.48179898
25MAP3K41.42717302
26MAP2K71.38531242
27ATR1.33572651
28SMG11.33016461
29MAP3K81.31768836
30DYRK31.31238272
31CHEK21.29477291
32EIF2AK31.26648982
33PIM11.23303807
34AURKA1.21868860
35PASK1.20211528
36CDK71.18652563
37FLT31.18450030
38TESK21.17928632
39TAF11.15789609
40MAP3K100.97939791
41CDK40.97355173
42MAP4K10.95615302
43PLK30.90536304
44TSSK60.84462042
45MKNK10.83078938
46RPS6KA40.81017079
47CHEK10.80455825
48EIF2AK20.80324843
49TEC0.79645627
50CLK10.79404737
51STK100.75499587
52EEF2K0.74591201
53KDR0.72671225
54ATM0.67297699
55ICK0.64874635
56PAK40.63484452
57CDK90.63329068
58PIM20.61581168
59CDK20.61064628
60MAPKAPK30.60149627
61CDK120.59549086
62LRRK20.59251536
63MKNK20.58145466
64EPHA20.56967134
65TGFBR10.56545862
66MAP2K40.55610264
67PRKAA10.55179001
68DAPK30.54786619
69KIT0.52365373
70BTK0.49268684
71CDK10.48539631
72AKT20.47897258
73CSNK2A20.47469919
74CSNK2A10.47111415
75EPHA30.47099756
76NLK0.46673155
77MAP3K110.40993773
78RET0.39735188
79MAPK110.38836402
80PAK10.38359689
81PRKCQ0.38349447
82CDK60.37834845
83PBK0.37346271
84CAMK40.36576810
85MAP2K30.36554644
86CSF1R0.36268849
87GRK60.34737471
88BCKDK0.33433492
89MST40.33158391
90LYN0.33129825
91PKN20.32816539
92IRAK40.32116606
93CSNK1G10.31868741
94TXK0.31587533
95JAK20.30560622
96BRD40.30512852
97BRAF0.27340491
98CSNK1G30.25721220
99MELK0.24731885
100RAF10.24702746
101CAMKK20.24111308
102TRIB30.23279692
103PKN10.23059353
104CDK80.22674944
105SYK0.21813821
106CSNK1A1L0.21765939
107IKBKB0.21622319
108PRKDC0.21170216
109PIK3CG0.20526608
110YES10.18400392
111STK30.17860030
112DYRK1B0.17391175
113TESK10.17262209
114RPS6KL10.16616455
115RPS6KC10.16616455
116MAPKAPK50.15652945
117RPS6KA60.15323787
118NEK90.14629583
119TYK20.14564774
120PRKCI0.14319738
121BLK0.13830338
122BMPR1B0.13677805
123STK240.10098637
124PRKCD0.09748824
125CSNK1G20.08115933
126AKT30.07709457
127RPS6KA30.07207661
128RPS6KB10.06842212
129MAP2K20.06220541
130SGK10.06047779
131PRKCB0.05175712
132HCK0.05129281
133MAPK140.04645937
134CAMK1D0.04612791

Predicted pathways (KEGG)

RankGene SetZ-score
1* Systemic lupus erythematosus_Homo sapiens_hsa053225.51163715
2DNA replication_Homo sapiens_hsa030305.33687140
3Ribosome_Homo sapiens_hsa030104.47912125
4Mismatch repair_Homo sapiens_hsa034304.34488501
5Homologous recombination_Homo sapiens_hsa034403.19628017
6Base excision repair_Homo sapiens_hsa034103.17526320
7Spliceosome_Homo sapiens_hsa030402.99092320
8* Alcoholism_Homo sapiens_hsa050342.91485869
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.72169670
10Nucleotide excision repair_Homo sapiens_hsa034202.69780152
11RNA polymerase_Homo sapiens_hsa030202.63097695
12Pyrimidine metabolism_Homo sapiens_hsa002402.50861349
13Proteasome_Homo sapiens_hsa030502.45969591
14Fanconi anemia pathway_Homo sapiens_hsa034602.42713832
15One carbon pool by folate_Homo sapiens_hsa006702.40854140
16Cell cycle_Homo sapiens_hsa041102.37778448
17Non-homologous end-joining_Homo sapiens_hsa034502.33405222
18RNA transport_Homo sapiens_hsa030132.26799320
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71937066
20Viral carcinogenesis_Homo sapiens_hsa052031.64551497
21RNA degradation_Homo sapiens_hsa030181.49661548
22p53 signaling pathway_Homo sapiens_hsa041151.45971965
23Basal transcription factors_Homo sapiens_hsa030221.26442473
24Purine metabolism_Homo sapiens_hsa002301.22673032
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21967521
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19523945
27mRNA surveillance pathway_Homo sapiens_hsa030151.10205974
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.04096430
29Folate biosynthesis_Homo sapiens_hsa007901.02279691
30Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91538404
31Epstein-Barr virus infection_Homo sapiens_hsa051690.86491912
32Parkinsons disease_Homo sapiens_hsa050120.79335370
33Drug metabolism - other enzymes_Homo sapiens_hsa009830.79334190
34Huntingtons disease_Homo sapiens_hsa050160.78314654
35Herpes simplex infection_Homo sapiens_hsa051680.77948951
36Asthma_Homo sapiens_hsa053100.73021512
37Autoimmune thyroid disease_Homo sapiens_hsa053200.71355141
38Oocyte meiosis_Homo sapiens_hsa041140.69359705
39Pentose phosphate pathway_Homo sapiens_hsa000300.65520420
40Antigen processing and presentation_Homo sapiens_hsa046120.64443055
41Primary immunodeficiency_Homo sapiens_hsa053400.64108757
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62666873
43Graft-versus-host disease_Homo sapiens_hsa053320.58832037
44Oxidative phosphorylation_Homo sapiens_hsa001900.58262517
45Sulfur relay system_Homo sapiens_hsa041220.57051231
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.55835462
47N-Glycan biosynthesis_Homo sapiens_hsa005100.55414710
48HTLV-I infection_Homo sapiens_hsa051660.55203191
49Pancreatic cancer_Homo sapiens_hsa052120.54742524
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52378763
51Protein export_Homo sapiens_hsa030600.52217947
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51073380
53Biosynthesis of amino acids_Homo sapiens_hsa012300.50991579
54Hematopoietic cell lineage_Homo sapiens_hsa046400.46247466
55Viral myocarditis_Homo sapiens_hsa054160.46247120
56Small cell lung cancer_Homo sapiens_hsa052220.45986280
57Glutathione metabolism_Homo sapiens_hsa004800.45975051
58Type I diabetes mellitus_Homo sapiens_hsa049400.44413651
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43642727
60Apoptosis_Homo sapiens_hsa042100.39673827
61Glioma_Homo sapiens_hsa052140.39140352
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38845907
63Selenocompound metabolism_Homo sapiens_hsa004500.37878455
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37207530
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36301277
66Measles_Homo sapiens_hsa051620.35014701
67MicroRNAs in cancer_Homo sapiens_hsa052060.34522996
68Endometrial cancer_Homo sapiens_hsa052130.34453857
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34139873
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.31011971
71Inositol phosphate metabolism_Homo sapiens_hsa005620.30931741
72Platelet activation_Homo sapiens_hsa046110.30688563
73Legionellosis_Homo sapiens_hsa051340.30222278
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30181856
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.29322631
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28942133
77Alzheimers disease_Homo sapiens_hsa050100.27932904
78Hepatitis B_Homo sapiens_hsa051610.27591969
79Thyroid cancer_Homo sapiens_hsa052160.26397817
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.26138767
81Metabolic pathways_Homo sapiens_hsa011000.25909529
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25369215
83ErbB signaling pathway_Homo sapiens_hsa040120.24310551
84Prostate cancer_Homo sapiens_hsa052150.23244095
85Acute myeloid leukemia_Homo sapiens_hsa052210.22737373
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21073013
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19818574
88Lysine degradation_Homo sapiens_hsa003100.19107801
89Vitamin B6 metabolism_Homo sapiens_hsa007500.18690251
90Carbon metabolism_Homo sapiens_hsa012000.18425164
91Melanoma_Homo sapiens_hsa052180.17616983
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16953773
93Influenza A_Homo sapiens_hsa051640.15822427
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15770854
95Notch signaling pathway_Homo sapiens_hsa043300.15683271
96Caffeine metabolism_Homo sapiens_hsa002320.15502721
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14419215
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14293869
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14144543
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13958111
101Shigellosis_Homo sapiens_hsa051310.13798905
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.13532137
103Renin-angiotensin system_Homo sapiens_hsa046140.13288941
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13126706
105T cell receptor signaling pathway_Homo sapiens_hsa046600.12882647
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.12538540
107Prolactin signaling pathway_Homo sapiens_hsa049170.12290821
108Toxoplasmosis_Homo sapiens_hsa051450.11464485
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10874178
110Bladder cancer_Homo sapiens_hsa052190.10091408
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.10070458
112Leishmaniasis_Homo sapiens_hsa051400.09957388
113Hedgehog signaling pathway_Homo sapiens_hsa043400.09637283
114Galactose metabolism_Homo sapiens_hsa000520.09238775
115Basal cell carcinoma_Homo sapiens_hsa052170.09198607
116Chronic myeloid leukemia_Homo sapiens_hsa052200.07292850
117Pathways in cancer_Homo sapiens_hsa052000.06769837
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.06764661
119FoxO signaling pathway_Homo sapiens_hsa040680.06646032
120Type II diabetes mellitus_Homo sapiens_hsa049300.06369854
121Colorectal cancer_Homo sapiens_hsa052100.06366896
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.05997619
123Allograft rejection_Homo sapiens_hsa053300.05987552
124HIF-1 signaling pathway_Homo sapiens_hsa040660.04971084
125B cell receptor signaling pathway_Homo sapiens_hsa046620.04838001
126TGF-beta signaling pathway_Homo sapiens_hsa043500.04238946
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.04203479
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.03973775
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.03877839
130Non-small cell lung cancer_Homo sapiens_hsa052230.03396626
131Fructose and mannose metabolism_Homo sapiens_hsa000510.03080614
132Arachidonic acid metabolism_Homo sapiens_hsa005900.02437769
133Renal cell carcinoma_Homo sapiens_hsa052110.02011763
134Gap junction_Homo sapiens_hsa045400.01886344
135Other glycan degradation_Homo sapiens_hsa005110.01561287
1362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.01456814
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.01334041

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