HIST1H2AC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)7.52814528
2DNA replication-dependent nucleosome organization (GO:0034723)7.52814528
3neutrophil activation involved in immune response (GO:0002283)7.27144792
4thrombin receptor signaling pathway (GO:0070493)5.95690143
5leukocyte migration involved in inflammatory response (GO:0002523)5.83425104
6chromatin assembly (GO:0031497)5.77105166
7regulation of histone H3-K9 methylation (GO:0051570)5.64494416
8DNA unwinding involved in DNA replication (GO:0006268)5.49485492
9nucleosome assembly (GO:0006334)5.49277967
10regulation of platelet aggregation (GO:0090330)5.30073375
11mucosal immune response (GO:0002385)5.08285306
12protein localization to kinetochore (GO:0034501)5.04876809
13nuclear pore complex assembly (GO:0051292)4.96808112
14chromatin assembly or disassembly (GO:0006333)4.96655239
15nuclear pore organization (GO:0006999)4.96451985
16organ or tissue specific immune response (GO:0002251)4.80388200
17nucleosome organization (GO:0034728)4.74334969
18regulation of platelet activation (GO:0010543)4.74090165
19ribosomal small subunit assembly (GO:0000028)4.73103916
20protein-DNA complex assembly (GO:0065004)4.72334555
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.71711699
22DNA replication initiation (GO:0006270)4.70227512
23mitotic chromosome condensation (GO:0007076)4.67408629
24DNA strand elongation involved in DNA replication (GO:0006271)4.65081802
25protein neddylation (GO:0045116)4.62549692
26neutrophil activation (GO:0042119)4.62243063
27platelet aggregation (GO:0070527)4.59903003
28folic acid-containing compound biosynthetic process (GO:0009396)4.57715247
29viral transcription (GO:0019083)4.53388217
30CENP-A containing nucleosome assembly (GO:0034080)4.52388311
31chromatin remodeling at centromere (GO:0031055)4.52345162
32DNA strand elongation (GO:0022616)4.42733989
33telomere maintenance via semi-conservative replication (GO:0032201)4.42668945
34translational termination (GO:0006415)4.41854906
35protein localization to chromosome, centromeric region (GO:0071459)4.37260737
36blood coagulation, intrinsic pathway (GO:0007597)4.36123410
37protein-DNA complex subunit organization (GO:0071824)4.21291087
38G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.20941299
39negative regulation of thymocyte apoptotic process (GO:0070244)4.20284990
40sister chromatid segregation (GO:0000819)4.18014412
41positive regulation of mast cell activation (GO:0033005)4.15770495
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.15730215
43antibacterial humoral response (GO:0019731)4.15283772
44negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.11607070
45granulocyte activation (GO:0036230)4.08027300
46DNA replication-independent nucleosome organization (GO:0034724)4.06469310
47DNA replication-independent nucleosome assembly (GO:0006336)4.06469310
48mitotic recombination (GO:0006312)4.06208026
49adenosine receptor signaling pathway (GO:0001973)4.02711191
50lipoxygenase pathway (GO:0019372)4.01928295
51mitotic nuclear envelope disassembly (GO:0007077)4.01592654
52IMP biosynthetic process (GO:0006188)4.00593602
53translational elongation (GO:0006414)3.98159390
54telomere maintenance via recombination (GO:0000722)3.96387071
55negative regulation of homotypic cell-cell adhesion (GO:0034111)3.95085303
56positive regulation of macrophage differentiation (GO:0045651)3.93103236
57mitotic sister chromatid segregation (GO:0000070)3.92100582
58antimicrobial humoral response (GO:0019730)3.89254218
59innate immune response in mucosa (GO:0002227)3.88323536
60megakaryocyte development (GO:0035855)3.87515450
61pore complex assembly (GO:0046931)3.85388474
62DNA duplex unwinding (GO:0032508)3.81234151
63DNA geometric change (GO:0032392)3.81051072
64ribosomal small subunit biogenesis (GO:0042274)3.78695908
65triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.78297574
66membrane disassembly (GO:0030397)3.77702636
67nuclear envelope disassembly (GO:0051081)3.77702636
68positive regulation of endothelial cell differentiation (GO:0045603)3.77555906
69negative regulation of T-helper cell differentiation (GO:0045623)3.75355624
70negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.75355624
71maturation of SSU-rRNA (GO:0030490)3.73044016
72kinetochore organization (GO:0051383)3.70906502
73nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.70433513
74negative regulation of norepinephrine secretion (GO:0010700)3.69103664
75negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.69096595
76IMP metabolic process (GO:0046040)3.67510855
77positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.67114810
78ribosomal large subunit biogenesis (GO:0042273)3.64559898
79histone exchange (GO:0043486)3.60817539
80translational initiation (GO:0006413)3.59843354
81regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.56422173
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.54805306
83negative regulation of platelet activation (GO:0010544)3.52814760
84cellular protein complex disassembly (GO:0043624)3.52728504
85DNA topological change (GO:0006265)3.49274590
86DNA replication checkpoint (GO:0000076)3.46977634
87telomere maintenance via telomere lengthening (GO:0010833)3.45456519
88nucleotide-excision repair, DNA gap filling (GO:0006297)3.45084367
89protein targeting to ER (GO:0045047)3.44323818
90platelet degranulation (GO:0002576)3.43702678
91microglial cell activation (GO:0001774)3.43689295
92cotranslational protein targeting to membrane (GO:0006613)3.43451972
93attachment of spindle microtubules to kinetochore (GO:0008608)3.41926760
94translesion synthesis (GO:0019985)3.41854269
95positive regulation of gamma-delta T cell activation (GO:0046645)3.40847742
96regulation of integrin activation (GO:0033623)3.40825668
97leukocyte degranulation (GO:0043299)3.40723224
98meiotic chromosome segregation (GO:0045132)3.40325629
99homotypic cell-cell adhesion (GO:0034109)3.39882199
100viral life cycle (GO:0019058)3.39538924
101negative regulation of histone methylation (GO:0031061)3.39063609
102platelet formation (GO:0030220)3.36268817
103protein K6-linked ubiquitination (GO:0085020)3.36238195
104mitotic metaphase plate congression (GO:0007080)3.33980161
105positive regulation of receptor recycling (GO:0001921)3.33175817
106purinergic nucleotide receptor signaling pathway (GO:0035590)3.32902264
107regulation of gene silencing (GO:0060968)3.32722954
108dosage compensation (GO:0007549)3.32366647
109protein complex disassembly (GO:0043241)3.31466588
110establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30769762
111angiogenesis involved in wound healing (GO:0060055)3.30609114
112regulation of mast cell degranulation (GO:0043304)3.29364654
113negative regulation of cell killing (GO:0031342)3.29125151
114negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.29125151
115nucleobase biosynthetic process (GO:0046112)3.27847391
116telomere maintenance (GO:0000723)3.27063243
117negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.25687346
118regulation of B cell receptor signaling pathway (GO:0050855)3.24591479
119regulation of centriole replication (GO:0046599)3.24229065
120metaphase plate congression (GO:0051310)3.24180362
121telomere organization (GO:0032200)3.24149007
122regulation of spindle organization (GO:0090224)3.23903797
123regulation of centrosome cycle (GO:0046605)3.23387401
124platelet activation (GO:0030168)3.21784847
125positive regulation of chromosome segregation (GO:0051984)3.20288492
126DNA conformation change (GO:0071103)3.19779819
127negative regulation of T cell apoptotic process (GO:0070233)3.19378528
128myeloid cell activation involved in immune response (GO:0002275)3.18887778
129regulation of Golgi to plasma membrane protein transport (GO:0042996)3.18502217
130regulation of mast cell activation (GO:0033003)3.17703620
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17479082
132protein localization to endoplasmic reticulum (GO:0070972)3.17445175
133positive regulation of blood coagulation (GO:0030194)3.16643414
134positive regulation of hemostasis (GO:1900048)3.16643414
135regulation of mast cell activation involved in immune response (GO:0033006)3.14556963
136regulation of translational fidelity (GO:0006450)3.14263274
137chromosome condensation (GO:0030261)3.13158148
138cellular extravasation (GO:0045123)3.11822128
139antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.11335391
140postreplication repair (GO:0006301)3.11126459
141macromolecular complex disassembly (GO:0032984)3.09397505
142G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.09123747
143regulation of integrin-mediated signaling pathway (GO:2001044)3.08720226
144regulation of MHC class II biosynthetic process (GO:0045346)3.06300020
145detection of other organism (GO:0098543)3.05823004
146positive regulation of granulocyte differentiation (GO:0030854)3.05078864
147regulation of chromosome segregation (GO:0051983)3.04878852
148antigen processing and presentation via MHC class Ib (GO:0002475)3.04130607
149spindle assembly checkpoint (GO:0071173)3.03761868
150positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03719798
151positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03719798
152positive regulation of mitotic sister chromatid separation (GO:1901970)3.03719798
153antigen processing and presentation of endogenous antigen (GO:0019883)3.03699505
154regulation of helicase activity (GO:0051095)3.03242588
155ribonucleoprotein complex biogenesis (GO:0022613)3.03219492
156regulation of homotypic cell-cell adhesion (GO:0034110)3.02732653
157spindle checkpoint (GO:0031577)3.02614320
158regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01604299
159positive regulation of cellular amide metabolic process (GO:0034250)3.01469011
160ATP-dependent chromatin remodeling (GO:0043044)3.00833244
161regulation of T-helper 2 cell differentiation (GO:0045628)2.99448321
162establishment of chromosome localization (GO:0051303)2.99427667
163polyamine biosynthetic process (GO:0006596)2.96569740
164positive regulation of systemic arterial blood pressure (GO:0003084)2.96411629
165B cell receptor signaling pathway (GO:0050853)2.95969886
166somatic hypermutation of immunoglobulin genes (GO:0016446)2.95573893
167somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95573893
168nuclear-transcribed mRNA catabolic process (GO:0000956)2.95534508
169modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.93176034
170positive regulation by organism of defense response of other organism involved in symbiotic interact2.93176034
171modulation by symbiont of host immune response (GO:0052553)2.93176034
172positive regulation by symbiont of host defense response (GO:0052509)2.93176034
173modulation by symbiont of host defense response (GO:0052031)2.93176034
174modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.93176034
175regulation of regulatory T cell differentiation (GO:0045589)2.91806658
176positive regulation of coagulation (GO:0050820)2.90089727
177low-density lipoprotein particle remodeling (GO:0034374)2.89620089
178defense response to Gram-positive bacterium (GO:0050830)2.88364850
179detection of bacterium (GO:0016045)2.87862495
180termination of signal transduction (GO:0023021)2.87289668
181B cell mediated immunity (GO:0019724)2.87168192
182termination of G-protein coupled receptor signaling pathway (GO:0038032)2.86991166
183regulation of lipoprotein metabolic process (GO:0050746)2.86810283
184hepatocyte apoptotic process (GO:0097284)2.86122705
185positive regulation of cAMP-mediated signaling (GO:0043950)2.83734482
186regulation of megakaryocyte differentiation (GO:0045652)2.83284923
187negative regulation of heart rate (GO:0010459)2.83102814
188Arp2/3 complex-mediated actin nucleation (GO:0034314)2.81161959
189negative regulation of protein localization to plasma membrane (GO:1903077)2.80729643
190regulation of myeloid leukocyte mediated immunity (GO:0002886)2.80678874
191purinergic receptor signaling pathway (GO:0035587)2.80366989
192vesicle targeting (GO:0006903)2.77851673
193dendritic cell chemotaxis (GO:0002407)2.77266345
194positive regulation of B cell differentiation (GO:0045579)2.77100771
195positive regulation of mast cell degranulation (GO:0043306)2.75581227
196positive regulation of mast cell activation involved in immune response (GO:0033008)2.75581227
197regulation of macrophage derived foam cell differentiation (GO:0010743)2.74483043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.24969722
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.41960795
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.28882138
4SCL_19346495_ChIP-Seq_HPC-7_Human3.74832622
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.57976973
6SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.38884748
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.07178128
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.98104748
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.92072245
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87153886
11GATA1_19941826_ChIP-Seq_K562_Human2.84285949
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80674144
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.74989084
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70407541
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.67131347
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.66261088
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.63908660
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.61564243
19* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.52447406
20GATA2_19941826_ChIP-Seq_K562_Human2.46050056
21SPI1_23127762_ChIP-Seq_K562_Human2.41344692
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.39712366
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32599860
24GATA1_19941827_ChIP-Seq_MEL_Mouse2.30040159
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29910783
26* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.29029107
27IRF8_22096565_ChIP-ChIP_GC-B_Human2.24722251
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21569275
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21514081
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.18143783
31IRF8_27001747_Chip-Seq_BMDM_Mouse2.16030813
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.14952885
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.11929347
34* E2F1_21310950_ChIP-Seq_MCF-7_Human2.10442155
35MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09622745
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08372615
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07703191
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse12.3000569
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.82606079
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79467086
41* VDR_23849224_ChIP-Seq_CD4+_Human1.79225773
42* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.75282948
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.75231087
44RUNX_20019798_ChIP-Seq_JUKART_Human1.74410665
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73689691
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71981294
47SPI1_23547873_ChIP-Seq_NB4_Human1.70467069
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70429768
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65960288
50AR_21909140_ChIP-Seq_LNCAP_Human1.61456313
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60696717
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60139413
53* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58910003
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58143408
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.57444585
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56631617
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.55588798
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54482494
59XRN2_22483619_ChIP-Seq_HELA_Human1.53739842
60* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51779769
61MYB_26560356_Chip-Seq_TH2_Human1.50151437
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49776666
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49054686
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.46362236
65MAF_26560356_Chip-Seq_TH1_Human1.46075652
66ELK1_19687146_ChIP-ChIP_HELA_Human1.45556227
67UTX_26944678_Chip-Seq_JUKART_Human1.45193133
68* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45132913
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44753310
70VDR_24763502_ChIP-Seq_THP-1_Human1.44582021
71FOXP3_21729870_ChIP-Seq_TREG_Human1.43672489
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.42256912
73MYB_26560356_Chip-Seq_TH1_Human1.40209908
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40079247
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.39955401
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39532944
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38898091
78NCOR1_26117541_ChIP-Seq_K562_Human1.38773385
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37237032
80MYC_22102868_ChIP-Seq_BL_Human1.37133176
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36583632
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35986030
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34971680
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30009490
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29149376
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28476856
87GATA3_27048872_Chip-Seq_THYMUS_Human1.26021609
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25795411
89JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25528204
90* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24875100
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24844040
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24789732
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24193324
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22886891
95* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21477199
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20902252
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19641723
98MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19453262
99TCF7_22412390_ChIP-Seq_EML_Mouse1.17618212
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17348326
101* SALL4_22934838_ChIP-ChIP_CD34+_Human1.16890095
102ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16527793
103GATA1_19941827_ChIP-Seq_MEL86_Mouse1.15053021
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13997207
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12844230
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11838082
107TTF2_22483619_ChIP-Seq_HELA_Human1.11218706
108IRF1_19129219_ChIP-ChIP_H3396_Human1.09251788
109ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09103455
110ELK4_26923725_Chip-Seq_MESODERM_Mouse1.08435121
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07898253
112VDR_21846776_ChIP-Seq_THP-1_Human1.07510792
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07204387
114PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06446729
115DCP1A_22483619_ChIP-Seq_HELA_Human1.06124267
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05998939
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05092219
118CIITA_25753668_ChIP-Seq_RAJI_Human1.04845121
119PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04024229
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03004111
121CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02678183
122SPI1_20517297_ChIP-Seq_HL60_Human1.01646603
123PU_27001747_Chip-Seq_BMDM_Mouse1.01566000
124SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01541989
125NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01459037
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00139926
127SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99026139
128NANOG_16153702_ChIP-ChIP_HESCs_Human0.98657397
129ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96326752
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95950185
131PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95934391
132HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94741322
133* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94618486
134FOXO3_23340844_ChIP-Seq_DLD1_Human0.94441571
135FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93585615
136GABP_19822575_ChIP-Seq_HepG2_Human0.93299496
137MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92089044
138SMAD_19615063_ChIP-ChIP_OVARY_Human0.91043164
139* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90960416
140* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90642723
141* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90606689
142KDM5A_27292631_Chip-Seq_BREAST_Human0.90581821
143* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90419816
144STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90264422
145RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89629438
146PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89064716
147GATA3_26560356_Chip-Seq_TH2_Human0.88789288
148TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88285718
149GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85891937
150GATA1_22025678_ChIP-Seq_K562_Human0.83144283
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.79832813
152KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.79275591
153GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79197329
154TFEB_21752829_ChIP-Seq_HELA_Human0.78905655
155RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77597248
156GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76915482
157KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76889206
158NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76581865
159NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76581865
160E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76070471
161HTT_18923047_ChIP-ChIP_STHdh_Human0.76011052
162* MYC_18940864_ChIP-ChIP_HL60_Human0.75161255
163NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.74718649
164ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74352374
165* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.73553229
166CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73275282
167RXR_22158963_ChIP-Seq_LIVER_Mouse0.73192175
168* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.72856271
169GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71776682
170KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.71759913
171SALL1_21062744_ChIP-ChIP_HESCs_Human0.71358131
172CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69305747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology7.85336555
2MP0010094_abnormal_chromosome_stability5.20475147
3MP0003693_abnormal_embryo_hatching4.51085228
4MP0003724_increased_susceptibility_to4.46325120
5MP0003111_abnormal_nucleus_morphology4.44238569
6MP0003077_abnormal_cell_cycle4.03351048
7MP0008004_abnormal_stomach_pH3.90272092
8MP0004957_abnormal_blastocyst_morpholog3.69217808
9MP0010307_abnormal_tumor_latency3.33178759
10MP0008057_abnormal_DNA_replication3.28305884
11MP0003303_peritoneal_inflammation2.99613950
12MP0008058_abnormal_DNA_repair2.97846670
13MP0008007_abnormal_cellular_replicative2.67199771
14MP0010352_gastrointestinal_tract_polyps2.61419509
15MP0005083_abnormal_biliary_tract2.56743260
16MP0002396_abnormal_hematopoietic_system2.54287602
17MP0008932_abnormal_embryonic_tissue2.41810046
18MP0000350_abnormal_cell_proliferation2.29126430
19MP0000490_abnormal_crypts_of2.17382792
20MP0001730_embryonic_growth_arrest2.14587462
21MP0003123_paternal_imprinting2.11232797
22MP0004808_abnormal_hematopoietic_stem2.09005850
23MP0003656_abnormal_erythrocyte_physiolo2.05443278
24MP0005000_abnormal_immune_tolerance2.01013463
25MP0003828_pulmonary_edema1.97735619
26MP0004147_increased_porphyrin_level1.96801984
27MP0003300_gastrointestinal_ulcer1.90251687
28MP0000343_altered_response_to1.88527954
29MP0004510_myositis1.87877551
30MP0006054_spinal_hemorrhage1.81056658
31MP0004947_skin_inflammation1.74773466
32MP0008260_abnormal_autophagy1.74185479
33MP0002723_abnormal_immune_serum1.73879455
34MP0002419_abnormal_innate_immunity1.73393560
35MP0002132_abnormal_respiratory_system1.72907206
36MP0001851_eye_inflammation1.67063539
37MP0002148_abnormal_hypersensitivity_rea1.66136833
38MP0001697_abnormal_embryo_size1.60846773
39MP0002019_abnormal_tumor_incidence1.60075638
40MP0005076_abnormal_cell_differentiation1.59586221
41MP0005025_abnormal_response_to1.58197170
42MP0002080_prenatal_lethality1.55849360
43MP0003786_premature_aging1.54508002
44MP0002086_abnormal_extraembryonic_tissu1.54200589
45MP0001672_abnormal_embryogenesis/_devel1.54029657
46MP0005380_embryogenesis_phenotype1.54029657
47MP0004197_abnormal_fetal_growth/weight/1.53456806
48MP0005058_abnormal_lysosome_morphology1.52952268
49MP0003866_abnormal_defecation1.51334907
50MP0000313_abnormal_cell_death1.50543744
51MP0009764_decreased_sensitivity_to1.49998834
52MP0005397_hematopoietic_system_phenotyp1.48272634
53MP0001545_abnormal_hematopoietic_system1.48272634
54MP0002084_abnormal_developmental_patter1.46920629
55MP0010234_abnormal_vibrissa_follicle1.45577679
56MP0001533_abnormal_skeleton_physiology1.44193050
57MP0002085_abnormal_embryonic_tissue1.44181445
58MP0003121_genomic_imprinting1.41530849
59MP0001293_anophthalmia1.41209124
60MP0008877_abnormal_DNA_methylation1.40940391
61MP0000703_abnormal_thymus_morphology1.40297840
62MP0004130_abnormal_muscle_cell1.39150777
63MP0003705_abnormal_hypodermis_morpholog1.38827150
64MP0002398_abnormal_bone_marrow1.38131404
65MP0002095_abnormal_skin_pigmentation1.37413142
66MP0005387_immune_system_phenotype1.35603106
67MP0001790_abnormal_immune_system1.35603106
68MP0002722_abnormal_immune_system1.34265946
69MP0003984_embryonic_growth_retardation1.32034162
70MP0009785_altered_susceptibility_to1.31911896
71MP0001845_abnormal_inflammatory_respons1.30537943
72MP0002088_abnormal_embryonic_growth/wei1.29162854
73MP0000689_abnormal_spleen_morphology1.26426489
74MP0009763_increased_sensitivity_to1.25128385
75MP0000249_abnormal_blood_vessel1.22287471
76MP0003567_abnormal_fetal_cardiomyocyte1.21631189
77MP0000230_abnormal_systemic_arterial1.18907023
78MP0005084_abnormal_gallbladder_morpholo1.18315323
79MP0003806_abnormal_nucleotide_metabolis1.18187927
80MP0002877_abnormal_melanocyte_morpholog1.17704895
81MP0003638_abnormal_response/metabolism_1.17019170
82MP0003183_abnormal_peptide_metabolism1.15876005
83MP0002166_altered_tumor_susceptibility1.14224580
84MP0003191_abnormal_cellular_cholesterol1.12856002
85MP0000372_irregular_coat_pigmentation1.12172574
86MP0004084_abnormal_cardiac_muscle1.11712914
87MP0001663_abnormal_digestive_system1.11090340
88MP0003890_abnormal_embryonic-extraembry1.08238524
89MP0005167_abnormal_blood-brain_barrier1.07942343
90MP0004381_abnormal_hair_follicle1.06695835
91MP0000371_diluted_coat_color1.06083417
92MP0002429_abnormal_blood_cell1.05035212
93MP0009697_abnormal_copulation1.00227515
94MP0003453_abnormal_keratinocyte_physiol0.99163695
95MP0002006_tumorigenesis0.98494391
96MP0005085_abnormal_gallbladder_physiolo0.97318107
97MP0009765_abnormal_xenobiotic_induced0.96878244
98MP0000685_abnormal_immune_system0.96776626
99MP0002075_abnormal_coat/hair_pigmentati0.96206321
100MP0002405_respiratory_system_inflammati0.95712736
101MP0002998_abnormal_bone_remodeling0.94969226
102MP0003252_abnormal_bile_duct0.94291215
103MP0004036_abnormal_muscle_relaxation0.92056373
104MP0001879_abnormal_lymphatic_vessel0.91153147
105MP0000537_abnormal_urethra_morphology0.90943950
106MP0005410_abnormal_fertilization0.90485407
107MP0003879_abnormal_hair_cell0.89991302
108MP0001800_abnormal_humoral_immune0.89135162
109MP0002111_abnormal_tail_morphology0.88792260
110MP0002092_abnormal_eye_morphology0.88409631
111MP0009333_abnormal_splenocyte_physiolog0.87701833
112MP0008874_decreased_physiological_sensi0.86488148
113MP0004883_abnormal_blood_vessel0.86276428
114MP0000716_abnormal_immune_system0.86200686
115MP0005384_cellular_phenotype0.85903741
116MP0001915_intracranial_hemorrhage0.85431359
117MP0005621_abnormal_cell_physiology0.84627874
118MP0000358_abnormal_cell_content/0.84405305
119MP0003763_abnormal_thymus_physiology0.84318783
120MP0003937_abnormal_limbs/digits/tail_de0.83710531
121MP0003091_abnormal_cell_migration0.80716870
122MP0005451_abnormal_body_composition0.80619455
123MP0003566_abnormal_cell_adhesion0.80214831
124MP0002009_preneoplasia0.80205837
125MP0001835_abnormal_antigen_presentation0.79576917
126MP0008770_decreased_survivor_rate0.79209493
127MP0002452_abnormal_antigen_presenting0.78129851
128MP0009642_abnormal_blood_homeostasis0.77178708
129MP0008872_abnormal_physiological_respon0.76383531
130MP0005174_abnormal_tail_pigmentation0.75508648
131MP0010329_abnormal_lipoprotein_level0.75396928
132MP0002210_abnormal_sex_determination0.75180710
133MP0005023_abnormal_wound_healing0.74762680
134MP0003075_altered_response_to0.73482461
135MP0002420_abnormal_adaptive_immunity0.73459192
136MP0000733_abnormal_muscle_development0.72815334
137MP0000477_abnormal_intestine_morphology0.72521096
138MP0005409_darkened_coat_color0.71997358
139MP0000465_gastrointestinal_hemorrhage0.71961778
140MP0005666_abnormal_adipose_tissue0.71665890
141MP0001819_abnormal_immune_cell0.71631494
142MP0001145_abnormal_male_reproductive0.71190601
143MP0008469_abnormal_protein_level0.69199217
144MP0000015_abnormal_ear_pigmentation0.68614416
145MP0001186_pigmentation_phenotype0.67375854
146MP0002697_abnormal_eye_size0.67303386
147MP0005501_abnormal_skin_physiology0.65674733
148MP0003718_maternal_effect0.65258373
149MP0004484_altered_response_of0.64865852
150MP0003448_altered_tumor_morphology0.64817221
151MP0008775_abnormal_heart_ventricle0.64301719
152MP0003045_fibrosis0.64289422
153MP0001661_extended_life_span0.64090456
154MP0009278_abnormal_bone_marrow0.63846956
155MP0005310_abnormal_salivary_gland0.63515974
156MP0005075_abnormal_melanosome_morpholog0.63088879
157MP0001929_abnormal_gametogenesis0.62908647
158MP0000858_altered_metastatic_potential0.62172571
159MP0003436_decreased_susceptibility_to0.61802762
160MP0001873_stomach_inflammation0.60140931
161MP0005671_abnormal_response_to0.59340854
162MP0009703_decreased_birth_body0.59261804
163MP0002102_abnormal_ear_morphology0.57954944
164MP0003119_abnormal_digestive_system0.57089733
165MP0000653_abnormal_sex_gland0.56081422
166MP0010155_abnormal_intestine_physiology0.55433143
167MP0002925_abnormal_cardiovascular_devel0.55419319

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.86145745
2Increased mean platelet volume (HP:0011877)8.87059096
3Menorrhagia (HP:0000132)8.67944280
4Abnormal platelet volume (HP:0011876)8.63488138
5Petechiae (HP:0000967)8.31574746
6Purpura (HP:0000979)7.30649309
7Epistaxis (HP:0000421)6.98794226
8Gingival bleeding (HP:0000225)6.34145485
9Reticulocytopenia (HP:0001896)5.26253464
10Impaired platelet aggregation (HP:0003540)5.17134391
11Abnormal platelet function (HP:0011869)5.17134391
12Spontaneous hematomas (HP:0007420)5.10394403
13Hyperlipoproteinemia (HP:0010980)4.59953419
14Abnormality of cells of the erythroid lineage (HP:0012130)4.33588487
15Chromsome breakage (HP:0040012)4.14733696
16Eczematoid dermatitis (HP:0000976)3.92907952
17Abnormal number of erythroid precursors (HP:0012131)3.85469750
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84628021
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.70006845
20Abnormality of chromosome stability (HP:0003220)3.68350769
21Birth length less than 3rd percentile (HP:0003561)3.63284459
22Abnormality of macrophages (HP:0004311)3.59693021
23Colon cancer (HP:0003003)3.58535745
24Abnormality of the common coagulation pathway (HP:0010990)3.50819541
25Cutaneous melanoma (HP:0012056)3.47276598
26Pallor (HP:0000980)3.40441604
27Agnosia (HP:0010524)3.38040628
28Conjunctival telangiectasia (HP:0000524)3.36491498
29Ependymoma (HP:0002888)3.31053803
30Dyschromatopsia (HP:0007641)3.26477607
31Poikilocytosis (HP:0004447)3.25280743
32Macrocytic anemia (HP:0001972)3.23739973
33Selective tooth agenesis (HP:0001592)3.22248245
34Medulloblastoma (HP:0002885)3.19972737
35Bruising susceptibility (HP:0000978)3.12642598
36Recurrent abscess formation (HP:0002722)3.12248699
37Recurrent bacterial skin infections (HP:0005406)3.08431558
38Abnormality of reticulocytes (HP:0004312)3.07939819
39Rhabdomyosarcoma (HP:0002859)3.04253001
40Basal cell carcinoma (HP:0002671)3.02912695
41Abnormality of the vasculature of the conjunctiva (HP:0008054)3.02566458
42Myelodysplasia (HP:0002863)2.95947303
43Impulsivity (HP:0100710)2.92987213
44Meckel diverticulum (HP:0002245)2.88866510
45Thrombocytosis (HP:0001894)2.87608537
46Chronic obstructive pulmonary disease (HP:0006510)2.85937882
47Obstructive lung disease (HP:0006536)2.85937882
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.84108370
49Abnormality of the ileum (HP:0001549)2.80413789
50Abnormality of the preputium (HP:0100587)2.80327142
5111 pairs of ribs (HP:0000878)2.71615249
52Absent thumb (HP:0009777)2.71159680
53Poikiloderma (HP:0001029)2.62589053
54Encephalitis (HP:0002383)2.61829712
55Hepatosplenomegaly (HP:0001433)2.61288891
56Aplastic anemia (HP:0001915)2.59199296
57Inflammation of the large intestine (HP:0002037)2.58910327
58Astrocytoma (HP:0009592)2.58244744
59Abnormality of the astrocytes (HP:0100707)2.58244744
60Arterial thrombosis (HP:0004420)2.54822915
61Small intestinal stenosis (HP:0012848)2.54464153
62Duodenal stenosis (HP:0100867)2.54464153
63Abnormality of iron homeostasis (HP:0011031)2.52190561
64Sloping forehead (HP:0000340)2.50960524
65Amaurosis fugax (HP:0100576)2.50752735
66Papillary thyroid carcinoma (HP:0002895)2.48732218
67Autoimmune hemolytic anemia (HP:0001890)2.47121799
68Paralysis (HP:0003470)2.46011719
69Prominent nose (HP:0000448)2.45357926
70Acanthocytosis (HP:0001927)2.44679458
71Cafe-au-lait spot (HP:0000957)2.44299871
72Squamous cell carcinoma (HP:0002860)2.43737626
73Stomatitis (HP:0010280)2.42504532
74Abnormal pupillary function (HP:0007686)2.41345603
75Freckling (HP:0001480)2.40467951
76Hypochromic microcytic anemia (HP:0004840)2.40359461
77Polycythemia (HP:0001901)2.40343651
78Increased density of long bones (HP:0006392)2.39837976
79Colitis (HP:0002583)2.38659006
80Increased IgM level (HP:0003496)2.37864121
81Gastrointestinal inflammation (HP:0004386)2.37459060
82Neoplasm of the oral cavity (HP:0100649)2.35274839
83Joint swelling (HP:0001386)2.34229605
84IgM deficiency (HP:0002850)2.34179517
85Glioma (HP:0009733)2.33673813
86High pitched voice (HP:0001620)2.32369190
87Joint hemorrhage (HP:0005261)2.30677944
88Volvulus (HP:0002580)2.30099968
89Abnormality of the carotid arteries (HP:0005344)2.26778653
90Short 4th metacarpal (HP:0010044)2.26112470
91Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.26112470
92Neoplasm of the pancreas (HP:0002894)2.25101116
93Entropion (HP:0000621)2.22932982
94Patellar aplasia (HP:0006443)2.21470691
95Increased serum ferritin (HP:0003281)2.20889265
96Abnormality of transition element cation homeostasis (HP:0011030)2.19929559
97Chest pain (HP:0100749)2.19218141
98Abnormal auditory evoked potentials (HP:0006958)2.17296390
99Neoplasm of striated muscle (HP:0009728)2.16020257
100Gastrointestinal infarctions (HP:0005244)2.15877503
101Tinnitus (HP:0000360)2.13947067
102Abnormality of the labia minora (HP:0012880)2.13643730
103Increased nuchal translucency (HP:0010880)2.13025359
104Abnormality of the duodenum (HP:0002246)2.12893179
105Biliary tract neoplasm (HP:0100574)2.11524932
106Oral leukoplakia (HP:0002745)2.11117650
107Bone marrow hypocellularity (HP:0005528)2.10939444
108Lymphoma (HP:0002665)2.09156870
109IgA deficiency (HP:0002720)2.08847044
110Abnormality of DNA repair (HP:0003254)2.08102381
111Premature graying of hair (HP:0002216)2.06228904
112Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.05053548
113Meningitis (HP:0001287)2.04106274
114Proximal placement of thumb (HP:0009623)2.02992619
115Dysautonomia (HP:0002459)2.01718648
116Recurrent gram-negative bacterial infections (HP:0005420)2.01171838
117Absent radius (HP:0003974)2.00932999
118Breast hypoplasia (HP:0003187)2.00730686
119Spastic diplegia (HP:0001264)2.00719011
120Gingivitis (HP:0000230)2.00516206
121Deviation of the thumb (HP:0009603)2.00115269
122Aplasia/Hypoplasia of the patella (HP:0006498)1.99328168
123Abnormal number of incisors (HP:0011064)1.98166847
124Elevated erythrocyte sedimentation rate (HP:0003565)1.97753379
125Missing ribs (HP:0000921)1.97334403
126Ectopic kidney (HP:0000086)1.96541920
127Hypopigmentation of the fundus (HP:0007894)1.95317464
128Xanthomatosis (HP:0000991)1.94271014
129T lymphocytopenia (HP:0005403)1.94228053
130Abnormality of lateral ventricle (HP:0030047)1.94226547
131Episodic fever (HP:0001954)1.93786051
132Upper limb muscle weakness (HP:0003484)1.92982718
133Clubbing of toes (HP:0100760)1.92063876
134Acute lymphatic leukemia (HP:0006721)1.91436129
135Recurrent fungal infections (HP:0002841)1.91063848
136Myositis (HP:0100614)1.90949044
137Atresia of the external auditory canal (HP:0000413)1.90818648
138Myocardial infarction (HP:0001658)1.89496270
139Duplicated collecting system (HP:0000081)1.87482811
140Sandal gap (HP:0001852)1.87055256
141Tracheoesophageal fistula (HP:0002575)1.86004495
142Reticulocytosis (HP:0001923)1.85138393
143Abnormality of T cell number (HP:0011839)1.84333073
144Vasculitis (HP:0002633)1.84163948
145Orchitis (HP:0100796)1.83644752
146Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83403775
147Granulocytopenia (HP:0001913)1.83349960
148Abnormal lung lobation (HP:0002101)1.83009757
149Aplasia involving forearm bones (HP:0009822)1.81606247
150Absent forearm bone (HP:0003953)1.81606247
151Optic neuritis (HP:0100653)1.80812027
152Retrobulbar optic neuritis (HP:0100654)1.80812027
153Uterine leiomyosarcoma (HP:0002891)1.80272027
154Leiomyosarcoma (HP:0100243)1.80272027
155Neoplasm of the colon (HP:0100273)1.80117021
156Abnormality of B cell number (HP:0010975)1.79980664
157B lymphocytopenia (HP:0010976)1.79980664
158Acute hepatic failure (HP:0006554)1.79853314
159Urticaria (HP:0001025)1.79737878
160Spontaneous abortion (HP:0005268)1.79648005
161Osteomyelitis (HP:0002754)1.77827034
162Triphalangeal thumb (HP:0001199)1.77695300
163Recurrent skin infections (HP:0001581)1.77258237
164Leukocytosis (HP:0001974)1.76618154
165Microcytic anemia (HP:0001935)1.75910669
166Cellulitis (HP:0100658)1.75539728
167Slender long bone (HP:0003100)1.75060775
168Short thumb (HP:0009778)1.74689380
169Leukopenia (HP:0001882)1.74042782
170Thrombophlebitis (HP:0004418)1.73848813
171Distal lower limb amyotrophy (HP:0008944)1.73202835
172Mitral stenosis (HP:0001718)1.72191182
173Abnormality of the prostate (HP:0008775)1.71953977
174Pulmonary embolism (HP:0002204)1.71933208
175Ovarian neoplasm (HP:0100615)1.70927596
176Recurrent viral infections (HP:0004429)1.69891134
177Microretrognathia (HP:0000308)1.69760371
178Gastrointestinal carcinoma (HP:0002672)1.69678786
179Malignant gastrointestinal tract tumors (HP:0006749)1.69678786
180Thyroiditis (HP:0100646)1.69036593
181Cellular immunodeficiency (HP:0005374)1.67150262
182Abnormality of the calcaneus (HP:0008364)1.65150902
183Abnormality of the renal collecting system (HP:0004742)1.64823647
184Mucosal telangiectasiae (HP:0100579)1.64510197
185Vertigo (HP:0002321)1.64173907
186Bladder neoplasm (HP:0009725)1.64063820
187Bladder carcinoma (HP:0002862)1.64063820
188Transitional cell carcinoma of the bladder (HP:0006740)1.63334981
189Muscle fibrillation (HP:0010546)1.62224966
190Thyroid carcinoma (HP:0002890)1.60298179
191Abnormal delayed hypersensitivity skin test (HP:0002963)1.59812373
192Eosinophilia (HP:0001880)1.59211186
193Hypertriglyceridemia (HP:0002155)1.58533625
194Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.56408552

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.00294575
2ZAK5.55160011
3RIPK45.30982356
4VRK13.74100910
5CDC73.51175249
6MST43.24953541
7BMX2.95432808
8WEE12.75000624
9STK42.67002647
10BLK2.63187728
11RPS6KA52.44642995
12NEK22.32405619
13BUB12.32266280
14SCYL22.25877153
15SYK2.11609753
16PIK3CG2.10252823
17EEF2K2.03069009
18BMPR22.00400310
19MYLK1.93027706
20SRPK11.92624930
21ZAP701.85716791
22EIF2AK11.80952814
23AURKB1.76954959
24DYRK31.72803333
25MAP3K101.69600629
26RPS6KB21.68492756
27PTK2B1.67371060
28HCK1.64097920
29FES1.62603816
30MAP3K81.61588503
31FGR1.58353470
32ACVR1B1.57368898
33PIM11.57302260
34NME21.49786046
35CHEK21.46043986
36CDK91.45372595
37NEK11.44031873
38CSK1.40531306
39TAOK31.38101586
40FLT31.32780974
41IRAK41.32710040
42TTK1.29702523
43PLK11.28343238
44PKN21.26097853
45ATR1.25722626
46EPHA31.24876529
47GRK51.22819596
48CDK121.15434240
49AURKA1.09606771
50PASK1.08952515
51DAPK31.06404418
52RET1.04737107
53TGFBR11.02033850
54IRAK11.00531116
55BRSK20.99565649
56MAP3K30.97973348
57CDK40.96833218
58TNK20.94979077
59MAP3K20.94585566
60PIM20.93948172
61CDK70.93214408
62STK100.92584776
63JAK30.90967868
64IKBKB0.85099295
65EIF2AK30.81857389
66JAK10.81650366
67GRK60.80591550
68LMTK20.79912232
69EPHA20.78793184
70CHEK10.78754084
71YES10.77363094
72PLK30.76150061
73MAP3K60.75897722
74TESK20.75667897
75TSSK60.73501117
76STK240.73200171
77ITK0.73021726
78DYRK1B0.71564420
79PDK10.71089433
80ATM0.68651070
81LCK0.68033481
82TTN0.67679979
83LRRK20.67308781
84MAP3K50.67125476
85PAK40.65333341
86MAP3K10.63885776
87TXK0.62717163
88PDPK10.62338105
89EPHB10.61980353
90CDK20.60378026
91CCNB10.59594582
92AKT20.56967313
93PLK40.56725412
94MKNK10.56610211
95FER0.55016016
96KSR20.53667503
97MELK0.53630768
98TYK20.53577265
99RPS6KA40.53539897
100CDK60.53517383
101CSF1R0.52751077
102BRSK10.50687025
103MAPK120.50300425
104PKN10.48823500
105IRAK20.48522061
106TAOK20.48220389
107ERBB20.47969200
108MAP2K40.47890057
109TAOK10.47164587
110PRKCQ0.46051808
111CAMKK20.44906089
112FYN0.44766161
113PDGFRB0.44602577
114IRAK30.43801632
115CDK10.42760127
116MAP3K110.42291281
117PRPF4B0.41349676
118MAP4K10.40447533
119MAP2K10.40100921
120STK160.38823693
121MAPKAPK30.38293860
122FGFR30.38242378
123EIF2AK20.38126666
124ADRBK10.38061862
125PAK10.37888269
126NLK0.37553801
127IKBKE0.37052230
128CSNK2A20.35578641
129BRD40.33897920
130MAP2K30.32939317
131SGK30.32830361
132PRKACG0.32784305
133PRKD10.32632588
134NEK90.31878879
135RAF10.31584210
136PRKCD0.30591903
137MKNK20.29957809
138SGK20.29668981
139STK30.29564789
140CAMK1D0.29527890
141TRIB30.29229994
142ALK0.28086565
143TEC0.27089937
144PRKDC0.26505007
145BTK0.24893876
146CSNK1D0.24857909
147KIT0.24583499
148CLK10.23161824
149MARK30.23005744
150PRKAA10.22082999
151CSNK2A10.21976992
152LYN0.21204012
153ILK0.20876414
154PAK20.20668737
155JAK20.19734967
156MTOR0.19233268
157MAPK110.16242947
158RPS6KB10.15986754
159AKT10.15690288
160MATK0.15431004
161MAPK140.15006862
162KDR0.13938729
163PRKCI0.13681320
164RPS6KC10.12314605
165RPS6KL10.12314605
166MET0.11098087
167TRPM70.09803411

Predicted pathways (KEGG)

RankGene SetZ-score
1* Systemic lupus erythematosus_Homo sapiens_hsa053229.18971771
2* Alcoholism_Homo sapiens_hsa050345.15331212
3DNA replication_Homo sapiens_hsa030304.06917392
4Mismatch repair_Homo sapiens_hsa034303.41762657
5Viral carcinogenesis_Homo sapiens_hsa052032.85263354
6Ribosome_Homo sapiens_hsa030102.82768635
7One carbon pool by folate_Homo sapiens_hsa006702.51159447
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41512752
9Cell cycle_Homo sapiens_hsa041102.26806498
10Homologous recombination_Homo sapiens_hsa034402.26074451
11Base excision repair_Homo sapiens_hsa034102.23937762
12Spliceosome_Homo sapiens_hsa030402.18979654
13Nucleotide excision repair_Homo sapiens_hsa034202.16631572
14RNA transport_Homo sapiens_hsa030132.09735423
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03820475
16Non-homologous end-joining_Homo sapiens_hsa034502.00012046
17Fanconi anemia pathway_Homo sapiens_hsa034601.90902304
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.86186837
19Transcriptional misregulation in cancer_Homo sapiens_hsa052021.68918398
20Chemokine signaling pathway_Homo sapiens_hsa040621.58962506
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.57802912
22Pyrimidine metabolism_Homo sapiens_hsa002401.56173483
23RNA polymerase_Homo sapiens_hsa030201.55960415
24Osteoclast differentiation_Homo sapiens_hsa043801.53826878
25Staphylococcus aureus infection_Homo sapiens_hsa051501.47184953
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41871621
27p53 signaling pathway_Homo sapiens_hsa041151.38839826
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23901858
29Arachidonic acid metabolism_Homo sapiens_hsa005901.11514038
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10786161
31T cell receptor signaling pathway_Homo sapiens_hsa046601.10332745
32mRNA surveillance pathway_Homo sapiens_hsa030151.09650752
33Graft-versus-host disease_Homo sapiens_hsa053321.08286208
34RNA degradation_Homo sapiens_hsa030181.07858662
35Proteasome_Homo sapiens_hsa030501.02819039
36ECM-receptor interaction_Homo sapiens_hsa045121.01399301
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97444427
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97000591
39Gap junction_Homo sapiens_hsa045400.95462230
40Allograft rejection_Homo sapiens_hsa053300.95437502
41Autoimmune thyroid disease_Homo sapiens_hsa053200.94324354
42Tuberculosis_Homo sapiens_hsa051520.92788796
43Phagosome_Homo sapiens_hsa041450.89536422
44Endocytosis_Homo sapiens_hsa041440.89535218
45Endometrial cancer_Homo sapiens_hsa052130.87225371
46Basal transcription factors_Homo sapiens_hsa030220.79338520
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.78637940
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78462581
49Nitrogen metabolism_Homo sapiens_hsa009100.78447061
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.78234447
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77806417
52Herpes simplex infection_Homo sapiens_hsa051680.77534379
53Selenocompound metabolism_Homo sapiens_hsa004500.76670171
54Epstein-Barr virus infection_Homo sapiens_hsa051690.76169823
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74829914
56Antigen processing and presentation_Homo sapiens_hsa046120.73831028
57MicroRNAs in cancer_Homo sapiens_hsa052060.73268454
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71447334
59Purine metabolism_Homo sapiens_hsa002300.71238810
60Small cell lung cancer_Homo sapiens_hsa052220.70628083
61VEGF signaling pathway_Homo sapiens_hsa043700.68414499
62Choline metabolism in cancer_Homo sapiens_hsa052310.66659347
63HTLV-I infection_Homo sapiens_hsa051660.65196833
64Sulfur metabolism_Homo sapiens_hsa009200.64816766
65Renal cell carcinoma_Homo sapiens_hsa052110.64372417
66Oocyte meiosis_Homo sapiens_hsa041140.62711387
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62203436
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.60244432
69Pentose phosphate pathway_Homo sapiens_hsa000300.58966788
70Sulfur relay system_Homo sapiens_hsa041220.58210209
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56938954
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56890526
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.55121669
74Serotonergic synapse_Homo sapiens_hsa047260.54502093
75Focal adhesion_Homo sapiens_hsa045100.54276085
76Asthma_Homo sapiens_hsa053100.53570476
77Apoptosis_Homo sapiens_hsa042100.53229857
78Biosynthesis of amino acids_Homo sapiens_hsa012300.52609198
79Chronic myeloid leukemia_Homo sapiens_hsa052200.52565832
80Glycerolipid metabolism_Homo sapiens_hsa005610.52011347
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51982210
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50779217
83Pancreatic secretion_Homo sapiens_hsa049720.50149129
84Salmonella infection_Homo sapiens_hsa051320.47709029
85Legionellosis_Homo sapiens_hsa051340.47280023
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.47143875
87Bladder cancer_Homo sapiens_hsa052190.45849587
88Hepatitis C_Homo sapiens_hsa051600.45737501
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.45578922
90Thyroid cancer_Homo sapiens_hsa052160.45078953
91Rap1 signaling pathway_Homo sapiens_hsa040150.44348155
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43836807
93Folate biosynthesis_Homo sapiens_hsa007900.42687238
94Hepatitis B_Homo sapiens_hsa051610.42414615
95Complement and coagulation cascades_Homo sapiens_hsa046100.41434924
96Starch and sucrose metabolism_Homo sapiens_hsa005000.41428129
97Inositol phosphate metabolism_Homo sapiens_hsa005620.41201241
98TNF signaling pathway_Homo sapiens_hsa046680.41056417
99Non-small cell lung cancer_Homo sapiens_hsa052230.41014205
100Colorectal cancer_Homo sapiens_hsa052100.40204163
101Type I diabetes mellitus_Homo sapiens_hsa049400.38546241
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38216906
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.37933321
104Primary immunodeficiency_Homo sapiens_hsa053400.37012280
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36930701
106Amoebiasis_Homo sapiens_hsa051460.36465055
107Measles_Homo sapiens_hsa051620.36408196
108ErbB signaling pathway_Homo sapiens_hsa040120.35783386
109Hematopoietic cell lineage_Homo sapiens_hsa046400.35491523
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.35389919
111B cell receptor signaling pathway_Homo sapiens_hsa046620.34575343
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.34355890
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.34077654
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33605879
115Collecting duct acid secretion_Homo sapiens_hsa049660.33447318
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.33324059
117Long-term depression_Homo sapiens_hsa047300.32910355
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32672361
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32546295
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29670893
121Renin-angiotensin system_Homo sapiens_hsa046140.28905832
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.26526072
123mTOR signaling pathway_Homo sapiens_hsa041500.26405285
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23849288
125Pancreatic cancer_Homo sapiens_hsa052120.23545212
126Influenza A_Homo sapiens_hsa051640.23067348
127Lysine degradation_Homo sapiens_hsa003100.22548179
128Vitamin B6 metabolism_Homo sapiens_hsa007500.21794807
129Notch signaling pathway_Homo sapiens_hsa043300.21644735
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19627543
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19256826
132N-Glycan biosynthesis_Homo sapiens_hsa005100.19094643
133Melanoma_Homo sapiens_hsa052180.18778165
134Pathways in cancer_Homo sapiens_hsa052000.18252740
135Acute myeloid leukemia_Homo sapiens_hsa052210.17083024
136Carbon metabolism_Homo sapiens_hsa012000.16932870
137Leishmaniasis_Homo sapiens_hsa051400.16566117
138TGF-beta signaling pathway_Homo sapiens_hsa043500.16495908
139HIF-1 signaling pathway_Homo sapiens_hsa040660.16422687
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14246422
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14162288
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14021055
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13873840
144Prostate cancer_Homo sapiens_hsa052150.13281671
145Shigellosis_Homo sapiens_hsa051310.13002352
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12466781
147FoxO signaling pathway_Homo sapiens_hsa040680.11788902
148Viral myocarditis_Homo sapiens_hsa054160.10326495
149Proteoglycans in cancer_Homo sapiens_hsa052050.09733660
150Basal cell carcinoma_Homo sapiens_hsa052170.09588828
151Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.08692998
152Platelet activation_Homo sapiens_hsa046110.08559168
153Leukocyte transendothelial migration_Homo sapiens_hsa046700.08373429
154Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.06722551
155Toxoplasmosis_Homo sapiens_hsa051450.06196562
156Malaria_Homo sapiens_hsa051440.05767439
157Glutathione metabolism_Homo sapiens_hsa004800.05679365
158Jak-STAT signaling pathway_Homo sapiens_hsa046300.04885415
159Glioma_Homo sapiens_hsa052140.04773399

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