HIST1H1E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)7.51256290
2DNA replication-dependent nucleosome organization (GO:0034723)7.51256290
3regulation of histone H3-K9 methylation (GO:0051570)6.88602497
4* nucleosome assembly (GO:0006334)6.75385933
5* chromatin assembly (GO:0031497)6.08237176
6antibacterial humoral response (GO:0019731)6.05002553
7* nucleosome organization (GO:0034728)5.93134032
8* protein-DNA complex assembly (GO:0065004)5.70147283
9mitotic chromosome condensation (GO:0007076)5.69196992
10antimicrobial humoral response (GO:0019730)5.63917705
11DNA unwinding involved in DNA replication (GO:0006268)5.60485577
12protoporphyrinogen IX metabolic process (GO:0046501)5.59104372
13innate immune response in mucosa (GO:0002227)5.50712195
14protein localization to kinetochore (GO:0034501)5.47571264
15sister chromatid segregation (GO:0000819)5.37082626
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.29798642
17nuclear pore complex assembly (GO:0051292)5.29641345
18* protein-DNA complex subunit organization (GO:0071824)5.18156055
19nuclear pore organization (GO:0006999)5.15522147
20* chromatin assembly or disassembly (GO:0006333)5.12516859
21protein localization to chromosome, centromeric region (GO:0071459)4.99255185
22regulation of DNA endoreduplication (GO:0032875)4.92376673
23protoporphyrinogen IX biosynthetic process (GO:0006782)4.83529046
24kinetochore organization (GO:0051383)4.76470797
25mitotic sister chromatid segregation (GO:0000070)4.71642921
26CENP-A containing nucleosome assembly (GO:0034080)4.42512566
27mitotic sister chromatid cohesion (GO:0007064)4.42081156
28chromatin remodeling at centromere (GO:0031055)4.38151597
29defense response to Gram-positive bacterium (GO:0050830)4.36977438
30positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.28516641
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.28516641
32positive regulation of mitotic sister chromatid separation (GO:1901970)4.28516641
33mucosal immune response (GO:0002385)4.24319882
34erythrocyte maturation (GO:0043249)4.10929582
35mature B cell differentiation involved in immune response (GO:0002313)4.09079913
36pore complex assembly (GO:0046931)4.01172180
37organ or tissue specific immune response (GO:0002251)4.00443901
38regulation of centriole replication (GO:0046599)3.98886899
39DNA replication-independent nucleosome assembly (GO:0006336)3.98277135
40DNA replication-independent nucleosome organization (GO:0034724)3.98277135
41DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.97590159
42attachment of spindle microtubules to kinetochore (GO:0008608)3.93420700
43positive regulation of chromosome segregation (GO:0051984)3.93121741
44regulation of sister chromatid cohesion (GO:0007063)3.86849688
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.86680163
46DNA replication initiation (GO:0006270)3.82555206
47meiotic chromosome segregation (GO:0045132)3.82145041
48chromosome condensation (GO:0030261)3.81039118
49dosage compensation (GO:0007549)3.80479522
50DNA topological change (GO:0006265)3.80033466
51DNA duplex unwinding (GO:0032508)3.79645787
52DNA geometric change (GO:0032392)3.79049599
53negative regulation of histone methylation (GO:0031061)3.78476106
54mitotic recombination (GO:0006312)3.77178567
55mitotic nuclear envelope disassembly (GO:0007077)3.71441051
56DNA strand elongation involved in DNA replication (GO:0006271)3.67147796
57translesion synthesis (GO:0019985)3.62653833
58folic acid-containing compound biosynthetic process (GO:0009396)3.55681070
59histone exchange (GO:0043486)3.55469863
60porphyrin-containing compound biosynthetic process (GO:0006779)3.52871480
61telomere maintenance via semi-conservative replication (GO:0032201)3.52793863
62microtubule depolymerization (GO:0007019)3.52627503
63regulation of centrosome cycle (GO:0046605)3.52344463
64regulation of spindle organization (GO:0090224)3.52052337
65nuclear envelope disassembly (GO:0051081)3.50689634
66membrane disassembly (GO:0030397)3.50689634
67protein K6-linked ubiquitination (GO:0085020)3.50632780
68kinetochore assembly (GO:0051382)3.50605528
69DNA damage response, signal transduction resulting in transcription (GO:0042772)3.50221178
70B cell receptor signaling pathway (GO:0050853)3.48991368
71DNA strand elongation (GO:0022616)3.48126003
72protein localization to chromosome (GO:0034502)3.46039017
73mature B cell differentiation (GO:0002335)3.44059349
74double-strand break repair via nonhomologous end joining (GO:0006303)3.40606819
75non-recombinational repair (GO:0000726)3.40606819
76mitotic metaphase plate congression (GO:0007080)3.38229509
77metaphase plate congression (GO:0051310)3.36160066
78telomere maintenance via recombination (GO:0000722)3.35963735
79regulation of centrosome duplication (GO:0010824)3.33567513
80positive regulation of histone methylation (GO:0031062)3.33136943
81chromosome segregation (GO:0007059)3.33054814
82DNA packaging (GO:0006323)3.32445020
83DNA conformation change (GO:0071103)3.30797909
84regulation of RNA export from nucleus (GO:0046831)3.30098794
85negative regulation of B cell apoptotic process (GO:0002903)3.28604779
86postreplication repair (GO:0006301)3.26975602
87regulation of gene silencing (GO:0060968)3.26392566
88regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.26079885
89viral mRNA export from host cell nucleus (GO:0046784)3.24986402
90regulation of mitotic spindle organization (GO:0060236)3.22131580
91mitotic DNA integrity checkpoint (GO:0044774)3.22061479
92ribosomal small subunit assembly (GO:0000028)3.21934053
93DNA synthesis involved in DNA repair (GO:0000731)3.21545348
94negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.20653892
95ATP-dependent chromatin remodeling (GO:0043044)3.19271698
96regulation of chromosome segregation (GO:0051983)3.19014003
97mitotic G1 DNA damage checkpoint (GO:0031571)3.17736792
98definitive hemopoiesis (GO:0060216)3.17144854
99embryonic process involved in female pregnancy (GO:0060136)3.15987307
100nucleotide-excision repair, DNA gap filling (GO:0006297)3.14579818
101regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11582430
102DNA ligation (GO:0006266)3.09976383
103establishment of chromosome localization (GO:0051303)3.08995102
104DNA replication checkpoint (GO:0000076)3.07582625
105spindle checkpoint (GO:0031577)3.04906639
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02812096
107nucleosome disassembly (GO:0006337)3.00943174
108protein-DNA complex disassembly (GO:0032986)3.00943174
109pre-miRNA processing (GO:0031054)3.00745937
110tetrapyrrole biosynthetic process (GO:0033014)3.00472436
111hemoglobin metabolic process (GO:0020027)3.00423364
112heme biosynthetic process (GO:0006783)2.98439439
113erythrocyte development (GO:0048821)2.97671696
114regulation of translational fidelity (GO:0006450)2.97309479
115negative regulation of DNA repair (GO:0045738)2.97142615
116regulation of megakaryocyte differentiation (GO:0045652)2.91367007
117telomere maintenance (GO:0000723)2.88129477
118telomere organization (GO:0032200)2.86221372
119V(D)J recombination (GO:0033151)2.86009760
120maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.83751078
121peptidyl-lysine dimethylation (GO:0018027)2.70656060
122positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.68571928
123telomere maintenance via telomere lengthening (GO:0010833)2.67180182
124regulation of B cell apoptotic process (GO:0002902)2.65406035
125centrosome duplication (GO:0051298)2.55614801
126positive regulation of DNA-templated transcription, initiation (GO:2000144)2.54821923
127histone phosphorylation (GO:0016572)2.53269836
128negative regulation of chromosome segregation (GO:0051985)2.53258365
129positive regulation of B cell differentiation (GO:0045579)2.51607269
130determination of adult lifespan (GO:0008340)2.50749819
131regulation of sister chromatid segregation (GO:0033045)2.50549260
132regulation of mitotic sister chromatid separation (GO:0010965)2.50549260
133regulation of mitotic sister chromatid segregation (GO:0033047)2.50549260
134somatic hypermutation of immunoglobulin genes (GO:0016446)2.49710869
135somatic diversification of immune receptors via somatic mutation (GO:0002566)2.49710869
136nuclear envelope organization (GO:0006998)2.49413063
137positive regulation of cell cycle checkpoint (GO:1901978)2.48773037
138histone lysine demethylation (GO:0070076)2.46959742

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.31902292
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.31072066
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.53200131
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.17191384
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.47596981
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87312522
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.65435833
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33722451
9* E2F1_21310950_ChIP-Seq_MCF-7_Human2.25230336
10* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.20844980
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18293008
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.15009772
13SOX2_16153702_ChIP-ChIP_HESCs_Human2.05612429
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.00261411
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.8834697
16AR_21909140_ChIP-Seq_LNCAP_Human1.80179364
17CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.78918877
18TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.77951924
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77344088
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.70851342
21* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60828014
22SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.58445073
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57739064
24IRF1_19129219_ChIP-ChIP_H3396_Human1.53440339
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52906619
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51345730
27SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44138797
28ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39173360
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38944610
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38519517
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37453251
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37237328
33ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36243027
34GATA1_22025678_ChIP-Seq_K562_Human1.34174769
35KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30816850
36HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29780036
37* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25020841
38* VDR_23849224_ChIP-Seq_CD4+_Human1.21643682
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20610525
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19005182
41ELK1_19687146_ChIP-ChIP_HELA_Human1.17338117
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14175480
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14051460
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13627312
45MYC_22102868_ChIP-Seq_BL_Human1.13352301
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12715786
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09223153
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.07666627
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06802730
50* NANOG_16153702_ChIP-ChIP_HESCs_Human1.03910972
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.02131590
52* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00394871
53BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99472438
54STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97584349
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96067352
56* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94992964
57MYB_26560356_Chip-Seq_TH1_Human0.94574672
58GATA1_19941826_ChIP-Seq_K562_Human0.94208024
59VDR_21846776_ChIP-Seq_THP-1_Human0.93247910
60PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90412965
61TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89711680
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88052562
63ELF1_17652178_ChIP-ChIP_JURKAT_Human0.87843790
64VDR_24763502_ChIP-Seq_THP-1_Human0.87670148
65CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86618517
66ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85222556
67E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84689115
68FOXP3_21729870_ChIP-Seq_TREG_Human0.83629734
69* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82974317
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82871616
71NOTCH1_21737748_ChIP-Seq_TLL_Human0.82851624
72NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82839243
73MYB_26560356_Chip-Seq_TH2_Human0.81935992
74MYC_18358816_ChIP-ChIP_MESCs_Mouse0.81847912
75STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81525639
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81014433
77* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80855234
78THAP11_20581084_ChIP-Seq_MESCs_Mouse0.80160133
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.78687349
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.78550373
81XRN2_22483619_ChIP-Seq_HELA_Human0.77612087
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77280338
83GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76858608
84CREB1_15753290_ChIP-ChIP_HEK293T_Human0.75980351
85DCP1A_22483619_ChIP-Seq_HELA_Human0.75751928
86SCL_19346495_ChIP-Seq_HPC-7_Human0.74313260
87ZFX_18555785_ChIP-Seq_MESCs_Mouse0.73669767
88CIITA_25753668_ChIP-Seq_RAJI_Human0.73556949
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.73300516
90MYCN_18555785_ChIP-Seq_MESCs_Mouse0.72931450
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.72362308
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.72227863
93KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.72157069
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.72110655
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72016900
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.71773395
97ETS1_20019798_ChIP-Seq_JURKAT_Human0.71598525
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.71384784
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.70725991
100* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.70659528
101GATA1_22383799_ChIP-Seq_G1ME_Mouse0.69961019
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.68897472
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.65104720
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.64853711
105* UTX_26944678_Chip-Seq_JUKART_Human0.64402526
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.64352217
107ZNF263_19887448_ChIP-Seq_K562_Human0.63980193
108MYC_18940864_ChIP-ChIP_HL60_Human0.63358288
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.63034610
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.61587396
111TCF7_22412390_ChIP-Seq_EML_Mouse0.61468342
112MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.61223780
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.59567988
114MAF_26560356_Chip-Seq_TH1_Human0.59086041
115KDM5A_27292631_Chip-Seq_BREAST_Human0.58437665
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.58358545
117EST1_17652178_ChIP-ChIP_JURKAT_Human0.58252540
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.56264059
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.55653206
120NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.55632236
121* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.55629475

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.59795589
2MP0003656_abnormal_erythrocyte_physiolo3.87733364
3MP0003111_abnormal_nucleus_morphology3.82983383
4MP0004147_increased_porphyrin_level3.62954275
5MP0003077_abnormal_cell_cycle3.52222908
6MP0010307_abnormal_tumor_latency3.48695098
7MP0003693_abnormal_embryo_hatching3.18986707
8MP0008057_abnormal_DNA_replication2.94873526
9MP0003763_abnormal_thymus_physiology2.74587695
10MP0004957_abnormal_blastocyst_morpholog2.71127504
11MP0005645_abnormal_hypothalamus_physiol2.68795317
12MP0010352_gastrointestinal_tract_polyps2.61035529
13MP0003705_abnormal_hypodermis_morpholog2.40772147
14MP0005076_abnormal_cell_differentiation2.34203342
15MP0006054_spinal_hemorrhage2.28307472
16MP0000685_abnormal_immune_system2.25762031
17MP0008058_abnormal_DNA_repair2.15424464
18MP0004808_abnormal_hematopoietic_stem2.12300490
19MP0000350_abnormal_cell_proliferation2.04460013
20MP0003123_paternal_imprinting2.02840530
21MP0003121_genomic_imprinting2.00712206
22MP0002396_abnormal_hematopoietic_system1.96957194
23MP0008932_abnormal_embryonic_tissue1.94320714
24MP0008007_abnormal_cellular_replicative1.91622456
25MP0000490_abnormal_crypts_of1.81568172
26MP0001730_embryonic_growth_arrest1.81556495
27MP0001835_abnormal_antigen_presentation1.80055622
28MP0002009_preneoplasia1.79650794
29MP0002166_altered_tumor_susceptibility1.76985264
30MP0010234_abnormal_vibrissa_follicle1.68432003
31MP0004197_abnormal_fetal_growth/weight/1.67194982
32MP0002877_abnormal_melanocyte_morpholog1.64860687
33MP0008877_abnormal_DNA_methylation1.61060479
34MP0002086_abnormal_extraembryonic_tissu1.57380533
35MP0001293_anophthalmia1.55138528
36MP0001697_abnormal_embryo_size1.51671571
37MP0001800_abnormal_humoral_immune1.51025317
38MP0001661_extended_life_span1.50689231
39MP0009697_abnormal_copulation1.49404650
40MP0002095_abnormal_skin_pigmentation1.48739953
41MP0004185_abnormal_adipocyte_glucose1.47830726
42MP0001672_abnormal_embryogenesis/_devel1.45856970
43MP0005380_embryogenesis_phenotype1.45856970
44MP0000569_abnormal_digit_pigmentation1.42143674
45MP0002084_abnormal_developmental_patter1.39148997
46MP0002019_abnormal_tumor_incidence1.37955055
47MP0003300_gastrointestinal_ulcer1.37754160
48MP0002085_abnormal_embryonic_tissue1.33867840
49MP0010030_abnormal_orbit_morphology1.33387921
50MP0002080_prenatal_lethality1.33110092
51MP0003984_embryonic_growth_retardation1.32125160
52MP0002088_abnormal_embryonic_growth/wei1.30173445
53MP0002006_tumorigenesis1.30169695
54MP0000703_abnormal_thymus_morphology1.30158505
55MP0003787_abnormal_imprinting1.26662466
56MP0000537_abnormal_urethra_morphology1.26440938
57MP0001545_abnormal_hematopoietic_system1.25791879
58MP0005397_hematopoietic_system_phenotyp1.25791879
59MP0002092_abnormal_eye_morphology1.25282212
60MP0005220_abnormal_exocrine_pancreas1.22851299
61MP0000733_abnormal_muscle_development1.19244532
62MP0000313_abnormal_cell_death1.18757722
63MP0003937_abnormal_limbs/digits/tail_de1.18141415
64MP0003303_peritoneal_inflammation1.17766293
65MP0005671_abnormal_response_to1.16835712
66MP0002398_abnormal_bone_marrow1.16511522
67MP0002420_abnormal_adaptive_immunity1.14919325
68MP0000465_gastrointestinal_hemorrhage1.13964214
69MP0002722_abnormal_immune_system1.12486100
70MP0003890_abnormal_embryonic-extraembry1.10976206
71MP0001819_abnormal_immune_cell1.10199658
72MP0003567_abnormal_fetal_cardiomyocyte1.09973773
73MP0002697_abnormal_eye_size1.08772683
74MP0009053_abnormal_anal_canal1.06949405
75MP0009703_decreased_birth_body1.06539923
76MP0002452_abnormal_antigen_presenting1.02164369
77MP0005083_abnormal_biliary_tract1.01560548
78MP0005000_abnormal_immune_tolerance0.96044904
79MP0000689_abnormal_spleen_morphology0.96024100
80MP0002163_abnormal_gland_morphology0.94655166
81MP0005387_immune_system_phenotype0.93928912
82MP0001790_abnormal_immune_system0.93928912
83MP0001915_intracranial_hemorrhage0.92049744
84MP0000372_irregular_coat_pigmentation0.92027243
85MP0001286_abnormal_eye_development0.90935697
86MP0001727_abnormal_embryo_implantation0.90610435
87MP0000371_diluted_coat_color0.90045938
88MP0002723_abnormal_immune_serum0.88571744
89MP0002111_abnormal_tail_morphology0.88221931
90MP0000358_abnormal_cell_content/0.88134191
91MP0008770_decreased_survivor_rate0.86825149
92MP0003786_premature_aging0.83673272
93MP0005171_absent_coat_pigmentation0.82982960
94MP0001873_stomach_inflammation0.82938934
95MP0005647_abnormal_sex_gland0.82887225
96MP0005464_abnormal_platelet_physiology0.82496167
97MP0010678_abnormal_skin_adnexa0.81565124
98MP0002075_abnormal_coat/hair_pigmentati0.80881782
99MP0002429_abnormal_blood_cell0.80775883
100MP0002925_abnormal_cardiovascular_devel0.80687444
101MP0009672_abnormal_birth_weight0.80132401
102MP0005310_abnormal_salivary_gland0.79539531
103MP0004947_skin_inflammation0.78896929
104MP0003183_abnormal_peptide_metabolism0.78456543
105MP0008995_early_reproductive_senescence0.75900957
106MP0006035_abnormal_mitochondrial_morpho0.75218089
107MP0005451_abnormal_body_composition0.73252039
108MP0005391_vision/eye_phenotype0.72404528
109MP0006072_abnormal_retinal_apoptosis0.72180944
110MP0005025_abnormal_response_to0.71861241
111MP0004264_abnormal_extraembryonic_tissu0.70974405
112MP0002938_white_spotting0.70968128
113MP0003935_abnormal_craniofacial_develop0.70908959
114MP0009278_abnormal_bone_marrow0.70029865
115MP0003566_abnormal_cell_adhesion0.69559388
116MP0005621_abnormal_cell_physiology0.69506899
117MP0000432_abnormal_head_morphology0.69459156
118MP0005075_abnormal_melanosome_morpholog0.69249786
119MP0001851_eye_inflammation0.68396083
120MP0000383_abnormal_hair_follicle0.68387491
121MP0005408_hypopigmentation0.68054433
122MP0005384_cellular_phenotype0.67652751
123MP0001191_abnormal_skin_condition0.66828090
124MP0005023_abnormal_wound_healing0.65988836
125MP0009931_abnormal_skin_appearance0.65987434
126MP0000477_abnormal_intestine_morphology0.64903682
127MP0003718_maternal_effect0.63973806
128MP0000266_abnormal_heart_morphology0.63263268
129MP0005501_abnormal_skin_physiology0.62985214
130MP0000428_abnormal_craniofacial_morphol0.62575057
131MP0003941_abnormal_skin_development0.62120662
132MP0003453_abnormal_keratinocyte_physiol0.62076414
133MP0000015_abnormal_ear_pigmentation0.61859370
134MP0003115_abnormal_respiratory_system0.61776955
135MP0008438_abnormal_cutaneous_collagen0.60802689
136MP0002405_respiratory_system_inflammati0.60797006
137MP0001186_pigmentation_phenotype0.60512532
138MP0000716_abnormal_immune_system0.60322074
139MP0005266_abnormal_metabolism0.58344944
140MP0002083_premature_death0.57174628
141MP0000598_abnormal_liver_morphology0.57006538
142MP0003221_abnormal_cardiomyocyte_apopto0.55499162

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)6.53502034
2IgM deficiency (HP:0002850)6.44033685
3IgA deficiency (HP:0002720)5.69391695
4Hypochromic microcytic anemia (HP:0004840)5.11349990
5Colitis (HP:0002583)5.08601441
6Abnormality of the heme biosynthetic pathway (HP:0010472)4.46019223
7Acanthocytosis (HP:0001927)4.44524314
8Cellulitis (HP:0100658)4.02561442
9Volvulus (HP:0002580)3.95371253
10Short 4th metacarpal (HP:0010044)3.57137947
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.57137947
12Gastrointestinal stroma tumor (HP:0100723)3.49367486
13Chromsome breakage (HP:0040012)3.46105905
14Agammaglobulinemia (HP:0004432)3.45279633
15Reticulocytopenia (HP:0001896)3.22324973
16Abnormality of reticulocytes (HP:0004312)3.18863609
17Reticulocytosis (HP:0001923)3.16916592
18Abnormality of chromosome stability (HP:0003220)3.13776063
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.08955664
20Inflammation of the large intestine (HP:0002037)3.05724298
21Impulsivity (HP:0100710)3.01420093
22Abnormality of the fingertips (HP:0001211)2.98038983
23Recurrent sinusitis (HP:0011108)2.96569523
24Acute lymphatic leukemia (HP:0006721)2.91256248
25Cutaneous melanoma (HP:0012056)2.90459137
26Microvesicular hepatic steatosis (HP:0001414)2.89962530
27Gastrointestinal inflammation (HP:0004386)2.89013981
28Erythema (HP:0010783)2.75244531
29Increased nuchal translucency (HP:0010880)2.74081199
30B lymphocytopenia (HP:0010976)2.69355152
31Autoimmune hemolytic anemia (HP:0001890)2.65055623
32Clubbing of toes (HP:0100760)2.62916951
33Acute myeloid leukemia (HP:0004808)2.62150503
34Recurrent bronchitis (HP:0002837)2.60131729
35Birth length less than 3rd percentile (HP:0003561)2.59798246
36Insomnia (HP:0100785)2.59444967
37Colon cancer (HP:0003003)2.58352089
38Abnormality of cells of the erythroid lineage (HP:0012130)2.56036729
39Lymphopenia (HP:0001888)2.55572988
40Osteomyelitis (HP:0002754)2.55353088
41Recurrent viral infections (HP:0004429)2.53368014
42Abnormality of cells of the lymphoid lineage (HP:0012140)2.51031146
43Interstitial pulmonary disease (HP:0006530)2.50915927
44Nephroblastoma (Wilms tumor) (HP:0002667)2.49816760
45Prostate neoplasm (HP:0100787)2.46823673
46Chronic diarrhea (HP:0002028)2.46788655
47High pitched voice (HP:0001620)2.42720831
48Subacute progressive viral hepatitis (HP:0006572)2.42241162
49Abnormality of the 4th metacarpal (HP:0010012)2.39070136
50Prominent nose (HP:0000448)2.37603583
51Recurrent bacterial skin infections (HP:0005406)2.37193528
52Hypochromic anemia (HP:0001931)2.36600634
53Viral hepatitis (HP:0006562)2.36554638
54Abnormal number of erythroid precursors (HP:0012131)2.35294444
55Abnormality of B cell number (HP:0010975)2.34044506
56Sandal gap (HP:0001852)2.33250937
57Abnormality of T cell physiology (HP:0011840)2.31332696
58Eczematoid dermatitis (HP:0000976)2.29981341
59Embryonal renal neoplasm (HP:0011794)2.28811119
60Long eyelashes (HP:0000527)2.27566054
61Deviation of the thumb (HP:0009603)2.26067390
62Meningitis (HP:0001287)2.24786111
63Medulloblastoma (HP:0002885)2.24453966
64Cafe-au-lait spot (HP:0000957)2.23067351
65Dry hair (HP:0011359)2.22491971
66Rhabdomyosarcoma (HP:0002859)2.21453425
67Cholelithiasis (HP:0001081)2.21120379
68Onycholysis (HP:0001806)2.20140248
69Abnormality of the prostate (HP:0008775)2.19965145
70Proximal placement of thumb (HP:0009623)2.19717216
71Hypopigmentation of the fundus (HP:0007894)2.19244546
72Basal cell carcinoma (HP:0002671)2.19062728
73Lymphoma (HP:0002665)2.18839540
74Small intestinal stenosis (HP:0012848)2.18037577
75Duodenal stenosis (HP:0100867)2.18037577
76Leukopenia (HP:0001882)2.17263700
77Papillary thyroid carcinoma (HP:0002895)2.17029184
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.15690917
79Truncal obesity (HP:0001956)2.15067659
80Abnormality of DNA repair (HP:0003254)2.14363700
81Cortical dysplasia (HP:0002539)2.13851034
82Selective tooth agenesis (HP:0001592)2.13506524
83Meckel diverticulum (HP:0002245)2.13056976
84Ectopic kidney (HP:0000086)2.12989764
85Mediastinal lymphadenopathy (HP:0100721)2.08400416
86Atresia of the external auditory canal (HP:0000413)2.07913058
87Absent frontal sinuses (HP:0002688)2.06311619
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.03873935
89Ankyloglossia (HP:0010296)2.03558002
90Hepatitis (HP:0012115)2.02720034
91Abnormality of the ileum (HP:0001549)2.02719371
92Thyroiditis (HP:0100646)2.00810443
93Abnormality of pyrimidine metabolism (HP:0004353)2.00163155
94Patellar aplasia (HP:0006443)1.99941915
95Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99776651
96Poikiloderma (HP:0001029)1.99547059
97Abnormality of the preputium (HP:0100587)1.99107166
98Sparse scalp hair (HP:0002209)1.97403181
99Deep palmar crease (HP:0006191)1.96247416
100Recurrent abscess formation (HP:0002722)1.95903758
101Cutis marmorata (HP:0000965)1.95054030
102Deep philtrum (HP:0002002)1.94445284
103Renovascular hypertension (HP:0100817)1.93753876
104Neoplasm of the adrenal cortex (HP:0100641)1.93752630
105Myelodysplasia (HP:0002863)1.92831168
106Abnormal number of incisors (HP:0011064)1.92526892
107Gastrointestinal carcinoma (HP:0002672)1.91460321
108Malignant gastrointestinal tract tumors (HP:0006749)1.91460321
109Hypergonadotropic hypogonadism (HP:0000815)1.90363005
110Ependymoma (HP:0002888)1.90008289
111Recurrent pneumonia (HP:0006532)1.89562124
112Abnormality of the carotid arteries (HP:0005344)1.88068507
113Abnormality of oral frenula (HP:0000190)1.87618951
114Abnormal gallbladder morphology (HP:0012437)1.87554417
115Abnormality of chromosome segregation (HP:0002916)1.86942259
116Freckling (HP:0001480)1.86129126
117Papilloma (HP:0012740)1.84297045
118Verrucae (HP:0200043)1.84297045
119Astrocytoma (HP:0009592)1.83592192
120Abnormality of the astrocytes (HP:0100707)1.83592192
121Dysmetric saccades (HP:0000641)1.83550933
122Abnormality of the duodenum (HP:0002246)1.83152717
123Osteomalacia (HP:0002749)1.82720573
124Biliary tract neoplasm (HP:0100574)1.82284546
125Sloping forehead (HP:0000340)1.82188765
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.81918061
127Aplasia/Hypoplasia of the patella (HP:0006498)1.81884259
128Microtia (HP:0008551)1.81605552
129Macrocytic anemia (HP:0001972)1.80266082
130Lower limb hyperreflexia (HP:0002395)1.79927803
131Micronodular cirrhosis (HP:0001413)1.78613592
132Obsessive-compulsive behavior (HP:0000722)1.78463405
133Renal duplication (HP:0000075)1.78015164
134Duplicated collecting system (HP:0000081)1.77805419
135Cutaneous photosensitivity (HP:0000992)1.77184154
13611 pairs of ribs (HP:0000878)1.75927084
137Abnormality of the labia minora (HP:0012880)1.75390220
138Bone marrow hypocellularity (HP:0005528)1.74726067
139Ulnar bowing (HP:0003031)1.73837596
140Squamous cell carcinoma (HP:0002860)1.73572916
141Dyschromatopsia (HP:0007641)1.73466047
142Pallor (HP:0000980)1.73450338
143Hematochezia (HP:0002573)1.73420394
144Heterotopia (HP:0002282)1.71606472
145Missing ribs (HP:0000921)1.71108462
146Glioma (HP:0009733)1.71093120
147Low anterior hairline (HP:0000294)1.70957889
148Neoplasm of the oral cavity (HP:0100649)1.69909790
149Entropion (HP:0000621)1.69860550
150Orthostatic hypotension (HP:0001278)1.69482038
151Pustule (HP:0200039)1.66890776
152Hepatocellular carcinoma (HP:0001402)1.66604267
153Neonatal hypoglycemia (HP:0001998)1.66504922
154Recurrent lower respiratory tract infections (HP:0002783)1.65584151
155Embryonal neoplasm (HP:0002898)1.64369982
156Diaphragmatic weakness (HP:0009113)1.63951034
157Hyperacusis (HP:0010780)1.63947780
158Microcytic anemia (HP:0001935)1.63776482
159Septate vagina (HP:0001153)1.63755875
160Macroorchidism (HP:0000053)1.63495543
161Abnormal lung lobation (HP:0002101)1.63200420
162Neoplasm of striated muscle (HP:0009728)1.62594644
163Ureteral duplication (HP:0000073)1.62480844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.75654574
2ZAK5.76492395
3CDC73.65603543
4STK43.56165535
5VRK13.45966197
6RPS6KA52.75012557
7CDK122.35046802
8MAP3K102.23465034
9NEK22.14215274
10CDK91.94619865
11AURKB1.90687873
12SCYL21.89059404
13WEE11.71185765
14EEF2K1.70312265
15EIF2AK11.69824937
16CHEK21.65245792
17PIM11.63108371
18MAP3K81.62233867
19SMG11.53073635
20SRPK11.40415731
21PKN21.35396311
22DYRK31.33270915
23RPS6KB21.28865345
24TTK1.24964778
25CAMK1D1.20759704
26PBK1.20549378
27ATR1.15832004
28DYRK1B1.10048478
29PLK11.09498418
30BTK1.08545217
31CDK61.06055368
32BUB11.05409819
33STK101.03585235
34CDK41.01525370
35BRSK20.99690399
36ACVR1B0.98806071
37DAPK30.97075583
38TAF10.93824420
39NEK10.89792890
40PIK3CG0.89414082
41PKN10.88962672
42MELK0.88862609
43FRK0.85996239
44TTN0.84813189
45FLT30.84131569
46GRK60.83570947
47PLK30.82750386
48AURKA0.81914482
49CHEK10.81367161
50ATM0.80110659
51BRD40.79601239
52STK30.79569951
53CCNB10.76319864
54IRAK40.76139092
55PRPF4B0.75416494
56PASK0.75148996
57MAP2K30.71775926
58BRAF0.70143945
59LATS10.67713280
60SYK0.66390607
61BRSK10.64342681
62PRKAA10.62327570
63CDK70.60528505
64* CDK20.60466698
65PIM20.56758552
66LRRK20.56442792
67AKT20.54953854
68RAF10.54541096
69NME20.53869307
70TGFBR10.52340397
71BLK0.51983716
72RPS6KA40.50660746
73CDK80.50160330
74* CDK10.49440821
75BCKDK0.48868165
76ICK0.47811823
77TEC0.45465743
78EIF2AK20.44106496
79PLK40.43589219
80TRPM70.40939775
81MTOR0.40491113
82CHUK0.39514980
83ERBB20.39385971
84CAMK1G0.37967649
85MARK30.37728729
86CSNK1D0.37504180
87FGFR20.36203228
88NUAK10.34542148
89CSF1R0.34252332
90AKT30.33994540
91LYN0.32007046
92EIF2AK30.30767905
93PTK60.29470988
94PRKDC0.29376293
95MAP4K10.29197910
96MAPK140.29029365
97IKBKE0.28110173
98MST1R0.27424960
99KDR0.27224417
100RIPK10.27193145
101AKT10.26151011
102JAK20.26066834
103BMX0.26041069
104TBK10.24835443
105CSNK1A1L0.24127569
106SGK30.23134792
107KSR10.23132065
108PAK40.22953894
109RPS6KB10.22796964
110SGK10.22500556
111TRIB30.22437628
112MET0.22256085
113ROCK10.22188663
114MAP3K20.21990552
115EPHA20.21932761
116MKNK10.21283565
117MAPKAPK50.20976216
118CLK10.20540680
119MAPK110.20239216
120NEK90.20194443
121MAP3K60.20077653
122PDGFRA0.20049881
123CSNK1G30.20033737
124MAP3K140.19532963
125MST40.19503846
126PIK3CA0.19379108
127FGFR30.18322175
128CAMK40.17911266
129MAP3K40.17793385
130IKBKB0.17566320
131BMPR20.17176877
132PRKCQ0.17161264
133HCK0.17157169
134CSNK1G10.16550091
135PAK10.16348516
136CSNK2A20.14498175
137HIPK20.13098984
138NEK60.11951170

Predicted pathways (KEGG)

RankGene SetZ-score
1Alcoholism_Homo sapiens_hsa050346.22491981
2Viral carcinogenesis_Homo sapiens_hsa052033.32775556
3DNA replication_Homo sapiens_hsa030302.98127326
4Mismatch repair_Homo sapiens_hsa034302.40550647
5Cell cycle_Homo sapiens_hsa041102.31930092
6Systemic lupus erythematosus_Homo sapiens_hsa0532210.9654531
7Transcriptional misregulation in cancer_Homo sapiens_hsa052021.90719422
8One carbon pool by folate_Homo sapiens_hsa006701.75822428
9Non-homologous end-joining_Homo sapiens_hsa034501.69347509
10Base excision repair_Homo sapiens_hsa034101.61928526
11Fanconi anemia pathway_Homo sapiens_hsa034601.61277704
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.53109999
13Nucleotide excision repair_Homo sapiens_hsa034201.49143589
14Homologous recombination_Homo sapiens_hsa034401.46898900
15RNA transport_Homo sapiens_hsa030131.35744079
16Spliceosome_Homo sapiens_hsa030401.32999043
17Ribosome_Homo sapiens_hsa030101.30215195
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24995160
19p53 signaling pathway_Homo sapiens_hsa041151.23914396
20Asthma_Homo sapiens_hsa053101.08286869
21MicroRNAs in cancer_Homo sapiens_hsa052061.06579199
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06456182
23Small cell lung cancer_Homo sapiens_hsa052221.04832866
24Chronic myeloid leukemia_Homo sapiens_hsa052200.97250530
25mRNA surveillance pathway_Homo sapiens_hsa030150.94130878
26Allograft rejection_Homo sapiens_hsa053300.91815417
27Autoimmune thyroid disease_Homo sapiens_hsa053200.84894058
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84037508
29Non-small cell lung cancer_Homo sapiens_hsa052230.83600804
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82631604
31Pentose phosphate pathway_Homo sapiens_hsa000300.78059849
32HTLV-I infection_Homo sapiens_hsa051660.75120584
33Graft-versus-host disease_Homo sapiens_hsa053320.72498354
34Herpes simplex infection_Homo sapiens_hsa051680.72107457
35Bladder cancer_Homo sapiens_hsa052190.70754828
36Pyrimidine metabolism_Homo sapiens_hsa002400.68710077
37Pancreatic cancer_Homo sapiens_hsa052120.66478830
38Type I diabetes mellitus_Homo sapiens_hsa049400.63293835
39Oocyte meiosis_Homo sapiens_hsa041140.61092371
40Hepatitis B_Homo sapiens_hsa051610.60982429
41RNA degradation_Homo sapiens_hsa030180.60558400
42Prostate cancer_Homo sapiens_hsa052150.59466966
43Lysine degradation_Homo sapiens_hsa003100.57510283
44Colorectal cancer_Homo sapiens_hsa052100.57505345
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56626870
46Thyroid cancer_Homo sapiens_hsa052160.54814522
47Apoptosis_Homo sapiens_hsa042100.54186594
48Epstein-Barr virus infection_Homo sapiens_hsa051690.53750701
49Selenocompound metabolism_Homo sapiens_hsa004500.52874298
50FoxO signaling pathway_Homo sapiens_hsa040680.50642367
51Glioma_Homo sapiens_hsa052140.50480030
52Antigen processing and presentation_Homo sapiens_hsa046120.50216093
53Inositol phosphate metabolism_Homo sapiens_hsa005620.50173571
54Adherens junction_Homo sapiens_hsa045200.49630070
55Hematopoietic cell lineage_Homo sapiens_hsa046400.49135963
56Biosynthesis of amino acids_Homo sapiens_hsa012300.48954556
57Endometrial cancer_Homo sapiens_hsa052130.48738868
58mTOR signaling pathway_Homo sapiens_hsa041500.46811842
59Measles_Homo sapiens_hsa051620.41897313
60TGF-beta signaling pathway_Homo sapiens_hsa043500.41100008
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41059870
62Melanoma_Homo sapiens_hsa052180.40430857
63B cell receptor signaling pathway_Homo sapiens_hsa046620.40328265
64Sulfur relay system_Homo sapiens_hsa041220.39574753
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.39358359
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39294531
67Proteoglycans in cancer_Homo sapiens_hsa052050.38968415
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.38716396
69Malaria_Homo sapiens_hsa051440.37621608
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35568270
71Viral myocarditis_Homo sapiens_hsa054160.34989487
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33192756
73RNA polymerase_Homo sapiens_hsa030200.31739072
74Notch signaling pathway_Homo sapiens_hsa043300.31486388
75Basal transcription factors_Homo sapiens_hsa030220.31235453
76Basal cell carcinoma_Homo sapiens_hsa052170.30849831
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30279755
78Renin-angiotensin system_Homo sapiens_hsa046140.30267432
79Pathways in cancer_Homo sapiens_hsa052000.29815201
80Carbon metabolism_Homo sapiens_hsa012000.29772719
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28655773
82Hippo signaling pathway_Homo sapiens_hsa043900.28211350
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26807488
84Focal adhesion_Homo sapiens_hsa045100.24446414
85Vitamin B6 metabolism_Homo sapiens_hsa007500.23933182
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.23586859
87Influenza A_Homo sapiens_hsa051640.23316766
88N-Glycan biosynthesis_Homo sapiens_hsa005100.23028215
89Acute myeloid leukemia_Homo sapiens_hsa052210.22653242
90AMPK signaling pathway_Homo sapiens_hsa041520.22300721
91Primary immunodeficiency_Homo sapiens_hsa053400.21870748
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21757279
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21465702
94HIF-1 signaling pathway_Homo sapiens_hsa040660.21354037
95Platelet activation_Homo sapiens_hsa046110.20383028
96Toxoplasmosis_Homo sapiens_hsa051450.20260667
97ErbB signaling pathway_Homo sapiens_hsa040120.19722134
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19297709
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19089911
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18831873
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18466825
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17747788
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17033372
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16969930
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16957550
106Purine metabolism_Homo sapiens_hsa002300.16389474
107Legionellosis_Homo sapiens_hsa051340.16370708
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16085060
109Fructose and mannose metabolism_Homo sapiens_hsa000510.15665371
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15641848
111Dorso-ventral axis formation_Homo sapiens_hsa043200.15231649
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14509014
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14353018
114Leishmaniasis_Homo sapiens_hsa051400.14120343
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13895371
116Prolactin signaling pathway_Homo sapiens_hsa049170.13776355
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.13353956
118VEGF signaling pathway_Homo sapiens_hsa043700.13287454
119Tight junction_Homo sapiens_hsa045300.12599718
120ECM-receptor interaction_Homo sapiens_hsa045120.11714133
121ABC transporters_Homo sapiens_hsa020100.11226195
122Type II diabetes mellitus_Homo sapiens_hsa049300.10961772
123Osteoclast differentiation_Homo sapiens_hsa043800.10876197
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.10538111
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.10397305
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.09487610
127Wnt signaling pathway_Homo sapiens_hsa043100.09272218

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