HIPK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1carnitine shuttle (GO:0006853)4.77941682
2fatty acid transmembrane transport (GO:1902001)4.71985592
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.16326537
4plasma membrane repair (GO:0001778)3.94318161
5regulation of sequestering of triglyceride (GO:0010889)3.94112044
6sarcomere organization (GO:0045214)3.82879042
7positive regulation of fatty acid beta-oxidation (GO:0032000)3.81844479
8carnitine transmembrane transport (GO:1902603)3.80203964
9cardiac myofibril assembly (GO:0055003)3.76351520
10negative regulation of potassium ion transmembrane transport (GO:1901380)3.67020217
11detection of molecule of bacterial origin (GO:0032490)3.64691012
12regulation of skeletal muscle contraction (GO:0014819)3.63223277
13muscle filament sliding (GO:0030049)3.61531886
14actin-myosin filament sliding (GO:0033275)3.61531886
15amino-acid betaine transport (GO:0015838)3.54075446
16carnitine transport (GO:0015879)3.54075446
17regulation of relaxation of muscle (GO:1901077)3.51336456
18positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.50687135
19positive regulation of fatty acid oxidation (GO:0046321)3.49567172
20myofibril assembly (GO:0030239)3.46013291
21low-density lipoprotein particle clearance (GO:0034383)3.39374754
22regulation of fatty acid oxidation (GO:0046320)3.38759079
23valine metabolic process (GO:0006573)3.35741470
24positive regulation of gamma-delta T cell activation (GO:0046645)3.33022976
25intracellular lipid transport (GO:0032365)3.32814191
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.24577264
27regulation of fatty acid beta-oxidation (GO:0031998)3.23214177
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.21427100
29regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.18293621
30macrophage activation involved in immune response (GO:0002281)3.17899094
31fatty acid beta-oxidation (GO:0006635)3.17537456
32tricarboxylic acid cycle (GO:0006099)3.16984901
332-oxoglutarate metabolic process (GO:0006103)3.16627326
34actin-mediated cell contraction (GO:0070252)3.14827790
35regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.14139592
36cellular response to epinephrine stimulus (GO:0071872)3.04024190
37regulation of p38MAPK cascade (GO:1900744)3.03975812
38lysine metabolic process (GO:0006553)3.03566254
39lysine catabolic process (GO:0006554)3.03566254
40cellular extravasation (GO:0045123)3.01957084
41growth hormone receptor signaling pathway (GO:0060396)2.97171220
42modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.96484986
43positive regulation by organism of defense response of other organism involved in symbiotic interact2.96484986
44modulation by symbiont of host immune response (GO:0052553)2.96484986
45positive regulation by symbiont of host defense response (GO:0052509)2.96484986
46modulation by symbiont of host defense response (GO:0052031)2.96484986
47modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.96484986
48positive regulation of glycolytic process (GO:0045821)2.94196679
49regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.93920179
50positive regulation of p38MAPK cascade (GO:1900745)2.91126411
51germinal center formation (GO:0002467)2.88326120
52sarcoplasmic reticulum calcium ion transport (GO:0070296)2.86315253
53interleukin-6-mediated signaling pathway (GO:0070102)2.84062582
54negative regulation of cell killing (GO:0031342)2.83836114
55negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.83836114
56insulin-like growth factor receptor signaling pathway (GO:0048009)2.83742568
57detection of external biotic stimulus (GO:0098581)2.83562248
58positive regulation of glycogen biosynthetic process (GO:0045725)2.82945583
59cardiac muscle contraction (GO:0060048)2.82088725
60actomyosin structure organization (GO:0031032)2.82029909
61tricarboxylic acid metabolic process (GO:0072350)2.81212522
62response to epinephrine (GO:0071871)2.80147354
63actin filament-based movement (GO:0030048)2.79968651
64bundle of His cell to Purkinje myocyte communication (GO:0086069)2.79918619
65fatty acid oxidation (GO:0019395)2.79834865
66detection of other organism (GO:0098543)2.78508216
67regulation of B cell receptor signaling pathway (GO:0050855)2.77317754
68relaxation of cardiac muscle (GO:0055119)2.76789681
69regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.76560925
70cellular response to ethanol (GO:0071361)2.75365935
71neutrophil activation involved in immune response (GO:0002283)2.75158977
72fatty acid homeostasis (GO:0055089)2.73165581
73striated muscle atrophy (GO:0014891)2.72939734
74lipid oxidation (GO:0034440)2.72689773
75biotin metabolic process (GO:0006768)2.71945772
76protein localization to endosome (GO:0036010)2.70846676
77macrophage activation (GO:0042116)2.69957778
78regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.66875218
79positive regulation of histone deacetylation (GO:0031065)2.66623212
80regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.66169238
81microglial cell activation (GO:0001774)2.64699516
82regulation of cholesterol storage (GO:0010885)2.64053083
83response to peptidoglycan (GO:0032494)2.63847562
84Golgi transport vesicle coating (GO:0048200)2.62444490
85COPI coating of Golgi vesicle (GO:0048205)2.62444490
86vascular endothelial growth factor signaling pathway (GO:0038084)2.61671444
87regulation of gamma-delta T cell activation (GO:0046643)2.60964491
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.60683173
89negative regulation of fatty acid transport (GO:2000192)2.58740844
90fatty acid catabolic process (GO:0009062)2.58671810
91cardiac muscle cell development (GO:0055013)2.58544459
92triglyceride catabolic process (GO:0019433)2.58450018
93positive regulation of cellular amide metabolic process (GO:0034250)2.56685368
94regulation of sarcomere organization (GO:0060297)2.55235641
95heart trabecula formation (GO:0060347)2.55186483
96quaternary ammonium group transport (GO:0015697)2.55175439
97regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.54023912
98ventricular cardiac muscle cell action potential (GO:0086005)2.53858615
99cellular response to growth hormone stimulus (GO:0071378)2.53303884
100muscle hypertrophy (GO:0014896)2.52978227
101regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.52743573
102cardiac muscle hypertrophy (GO:0003300)2.51703596
103phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.50911827
104positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.50208279
105regulation of acyl-CoA biosynthetic process (GO:0050812)2.48399175
106neutral lipid catabolic process (GO:0046461)2.48338330
107acylglycerol catabolic process (GO:0046464)2.48338330
108response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.46947231
109cardiac cell development (GO:0055006)2.46755633
110positive regulation of lipid catabolic process (GO:0050996)2.45096772
111striated muscle hypertrophy (GO:0014897)2.44532217
112positive regulation of glycogen metabolic process (GO:0070875)2.44471293
113negative regulation of heart growth (GO:0061117)2.44294683
114negative regulation of cardiac muscle tissue growth (GO:0055022)2.44294683
115positive regulation of cellular response to insulin stimulus (GO:1900078)2.44205940
116glycogen catabolic process (GO:0005980)2.44151409
117positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.44056190
118detection of biotic stimulus (GO:0009595)2.43373819
119skeletal muscle adaptation (GO:0043501)2.42938498
120macroautophagy (GO:0016236)2.42585328
121skeletal muscle contraction (GO:0003009)2.42569584
122striated muscle contraction (GO:0006941)2.41936516
123regulation of macrophage cytokine production (GO:0010935)2.41568111
124fibroblast migration (GO:0010761)2.41452100
125regulation of glucose import in response to insulin stimulus (GO:2001273)2.41304546
126alpha-linolenic acid metabolic process (GO:0036109)2.40764678
127phospholipid homeostasis (GO:0055091)2.40043175
128regulation of gamma-delta T cell differentiation (GO:0045586)2.40041555
129response to inactivity (GO:0014854)2.39139728
130regulation of interferon-beta biosynthetic process (GO:0045357)2.38887091
131positive regulation of lipid storage (GO:0010884)2.38719376
132negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.38010851
133hypotonic response (GO:0006971)2.37961156
134production of molecular mediator involved in inflammatory response (GO:0002532)2.37412895
135apoptotic cell clearance (GO:0043277)2.37208078
136COPII vesicle coating (GO:0048208)2.35508154
137negative regulation of cell size (GO:0045792)2.35372759
138regulation of the force of heart contraction (GO:0002026)2.35141689
139positive regulation of receptor recycling (GO:0001921)2.34980555
140cell communication involved in cardiac conduction (GO:0086065)2.34881623
141interkinetic nuclear migration (GO:0022027)2.34482811
142negative regulation of fatty acid biosynthetic process (GO:0045717)2.34075611
143negative regulation of interleukin-12 production (GO:0032695)2.33508702
144creatine metabolic process (GO:0006600)2.31309745
145succinate metabolic process (GO:0006105)2.30886836
146regulation of cholesterol homeostasis (GO:2000188)2.30579871
147detection of bacterium (GO:0016045)2.30316541
148response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.29727845
149response to host (GO:0075136)2.29727845
150response to host defenses (GO:0052200)2.29727845
151striated muscle adaptation (GO:0014888)2.28482214
152glucan catabolic process (GO:0009251)2.28356627
153regulation of germinal center formation (GO:0002634)2.28312415
154regulation of actin filament-based movement (GO:1903115)2.27520577
155regulation of necroptotic process (GO:0060544)2.25126611
156cellular response to thyroid hormone stimulus (GO:0097067)2.25071476
157response to host immune response (GO:0052572)2.24416320
158response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.24416320
159neutrophil mediated immunity (GO:0002446)2.23186662
160regulation of muscle hypertrophy (GO:0014743)2.22216148
161iron ion import (GO:0097286)2.22193897
162regulation of T-helper 2 cell differentiation (GO:0045628)2.21350233
163regulation of cardiac muscle hypertrophy (GO:0010611)2.19959496
164muscle atrophy (GO:0014889)2.19911469
165regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.19636408
166positive regulation of myoblast differentiation (GO:0045663)2.16080160
167antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.15721159
168regulation of skeletal muscle cell differentiation (GO:2001014)2.15613866
169B cell receptor signaling pathway (GO:0050853)2.15273451
170regulation of striated muscle contraction (GO:0006942)2.13159436
171antigen processing and presentation of endogenous antigen (GO:0019883)2.12445386
172positive regulation of macrophage cytokine production (GO:0060907)2.12427222
173pathway-restricted SMAD protein phosphorylation (GO:0060389)2.12041221
174negative regulation of T-helper cell differentiation (GO:0045623)2.10879108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.47415777
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.20877446
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.93427240
4* SMAD_19615063_ChIP-ChIP_OVARY_Human2.87957959
5* RXR_22158963_ChIP-Seq_LIVER_Mouse2.83835465
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.80848320
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75407740
8CLOCK_20551151_ChIP-Seq_293T_Human2.70144791
9* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.49567045
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.45334293
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.43223569
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.30797569
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.26318518
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.26126690
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.23097907
16ZNF263_19887448_ChIP-Seq_K562_Human2.08167649
17GATA1_22025678_ChIP-Seq_K562_Human2.06930382
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.00524104
19TBX20_22328084_ChIP-Seq_HEART_Mouse2.00472173
20TBX20_22080862_ChIP-Seq_HEART_Mouse2.00472173
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98594345
22IRF8_27001747_Chip-Seq_BMDM_Mouse1.98308420
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.94701038
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.89992384
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86621949
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83999343
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82565186
28RUNX_20019798_ChIP-Seq_JUKART_Human1.81082191
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79558189
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.79007932
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76199952
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.75051803
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.71436078
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58371033
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.57520635
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.56005885
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54199185
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.54110931
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53750986
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.53411695
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49486467
42SCL_19346495_ChIP-Seq_HPC-7_Human1.48370473
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.48223598
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47188656
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45731799
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44671241
47GBX2_23144817_ChIP-Seq_PC3_Human1.43217887
48CJUN_26792858_Chip-Seq_BT549_Human1.42521794
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.39919768
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36202064
51SPI1_23127762_ChIP-Seq_K562_Human1.35965279
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33929573
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33873250
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.33410015
55NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31249288
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31249288
57* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30203173
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29775719
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.29682806
60SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27294520
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26191205
62FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.22997447
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.22976499
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21920153
65GATA1_19941826_ChIP-Seq_K562_Human1.21113845
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20315959
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20075800
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19401771
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18659430
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18549560
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18400857
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15515897
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14386931
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12725487
75* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11681878
76AHR_22903824_ChIP-Seq_MCF-7_Human1.10609266
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10501337
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09370592
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09284766
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07958509
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07556017
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06775881
83TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.06582268
84* SMAD4_21799915_ChIP-Seq_A2780_Human1.06542158
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05257142
86AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05250044
87DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04144353
88* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04019180
89CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02982571
90* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02452837
91KDM2B_26808549_Chip-Seq_DND41_Human1.01602854
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01470910
93RXR_22108803_ChIP-Seq_LS180_Human1.01334930
94BCAT_22108803_ChIP-Seq_LS180_Human1.01039253
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.00064190
96IRF8_22096565_ChIP-ChIP_GC-B_Human0.99544805
97PU_27001747_Chip-Seq_BMDM_Mouse0.99364959
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98987134
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98528600
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97939894
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97459090
102TP63_23658742_ChIP-Seq_EP156T_Human0.96892143
103BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96770579
104* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96742184
105GATA2_19941826_ChIP-Seq_K562_Human0.96548253
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96311863
107* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96026229
108* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96012618
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95855845
110KDM2B_26808549_Chip-Seq_K562_Human0.94631497
111* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94419530
112NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93329130
113WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93228100
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.93022741
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92342900
116BRD4_25478319_ChIP-Seq_HGPS_Human0.91816524
117* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91639768
118FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91552465
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.91284107
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91244751
121TP53_16413492_ChIP-PET_HCT116_Human0.90955463
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.90766596
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90198887
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.90194697
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89733537
126KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88788787
127* TCF7_22412390_ChIP-Seq_EML_Mouse0.88556294
128NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88412933
129ISL1_27105846_Chip-Seq_CPCs_Mouse0.88349438
130* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88121708
131GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87977570
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87730824
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87259325
134TAF15_26573619_Chip-Seq_HEK293_Human0.86859895
135* STAT3_23295773_ChIP-Seq_U87_Human0.86728216
136RACK7_27058665_Chip-Seq_MCF-7_Human0.85899913
137* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85838030
138SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85610841
139WT1_19549856_ChIP-ChIP_CCG9911_Human0.85479297
140SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85342703
141SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85342703
142MYB_26560356_Chip-Seq_TH2_Human0.85292814
143SOX2_20726797_ChIP-Seq_SW620_Human0.84758834
144PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.84661037
145TCF4_18268006_ChIP-ChIP_LS174T_Human0.84593195
146GATA3_24758297_ChIP-Seq_MCF-7_Human0.84494416
147* E2F1_18555785_Chip-Seq_ESCs_Mouse0.84317966
148VDR_24787735_ChIP-Seq_THP-1_Human0.83918998
149RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83907746

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.97011144
2MP0004130_abnormal_muscle_cell3.29386073
3MP0004084_abnormal_cardiac_muscle3.29251425
4MP0003724_increased_susceptibility_to3.21454809
5MP0004036_abnormal_muscle_relaxation2.70303691
6MP0000751_myopathy2.68564943
7MP0003705_abnormal_hypodermis_morpholog2.64206551
8MP0005670_abnormal_white_adipose2.57201944
9MP0005666_abnormal_adipose_tissue2.54510580
10MP0003303_peritoneal_inflammation2.50020563
11MP0000569_abnormal_digit_pigmentation2.36825195
12MP0008438_abnormal_cutaneous_collagen2.33905345
13MP0000749_muscle_degeneration2.32880522
14MP0002877_abnormal_melanocyte_morpholog2.31993659
15MP0000013_abnormal_adipose_tissue2.28199105
16MP0004215_abnormal_myocardial_fiber2.27306062
17MP0004185_abnormal_adipocyte_glucose2.27265986
18MP0004087_abnormal_muscle_fiber2.26683357
19MP0005330_cardiomyopathy2.21853321
20MP0003646_muscle_fatigue2.21275233
21MP0005375_adipose_tissue_phenotype2.03330468
22MP0005275_abnormal_skin_tensile2.00961526
23MP0004145_abnormal_muscle_electrophysio1.89355420
24MP0005620_abnormal_muscle_contractility1.85893411
25MP0010630_abnormal_cardiac_muscle1.85750804
26MP0003828_pulmonary_edema1.83529391
27MP0008775_abnormal_heart_ventricle1.83408647
28MP0002972_abnormal_cardiac_muscle1.82953075
29MP0000750_abnormal_muscle_regeneration1.81635223
30MP0001835_abnormal_antigen_presentation1.81117023
31MP0000003_abnormal_adipose_tissue1.78009661
32MP0009780_abnormal_chondrocyte_physiolo1.76159944
33MP0005451_abnormal_body_composition1.71293177
34MP0003045_fibrosis1.68039105
35MP0002106_abnormal_muscle_physiology1.67927579
36MP0000747_muscle_weakness1.67104499
37MP0003300_gastrointestinal_ulcer1.66765448
38MP0005365_abnormal_bile_salt1.65892113
39MP0002269_muscular_atrophy1.64642871
40MP0005385_cardiovascular_system_phenoty1.63015168
41MP0001544_abnormal_cardiovascular_syste1.63015168
42MP0010368_abnormal_lymphatic_system1.60043436
43MP0003252_abnormal_bile_duct1.59693604
44MP0008004_abnormal_stomach_pH1.59563616
45MP0002971_abnormal_brown_adipose1.59447958
46MP0003436_decreased_susceptibility_to1.58748187
47MP0010234_abnormal_vibrissa_follicle1.57094959
48MP0006138_congestive_heart_failure1.56058968
49MP0004272_abnormal_basement_membrane1.51842039
50MP0002419_abnormal_innate_immunity1.48853368
51MP0003566_abnormal_cell_adhesion1.47723621
52MP0000759_abnormal_skeletal_muscle1.45983992
53MP0000465_gastrointestinal_hemorrhage1.45610743
54MP0005085_abnormal_gallbladder_physiolo1.43651667
55MP0008961_abnormal_basal_metabolism1.43532766
56MP0002139_abnormal_hepatobiliary_system1.43347490
57MP0005369_muscle_phenotype1.42713876
58MP0003690_abnormal_glial_cell1.40624672
59MP0004510_myositis1.40622843
60MP0005464_abnormal_platelet_physiology1.38490995
61MP0004883_abnormal_blood_vessel1.37965064
62MP0010329_abnormal_lipoprotein_level1.37791667
63MP0004233_abnormal_muscle_weight1.32797822
64MP0004484_altered_response_of1.32406479
65MP0006082_CNS_inflammation1.31393726
66MP0005164_abnormal_response_to1.30978773
67MP0003656_abnormal_erythrocyte_physiolo1.30943379
68MP0002998_abnormal_bone_remodeling1.25892026
69MP0002909_abnormal_adrenal_gland1.25584793
70MP0002166_altered_tumor_susceptibility1.25251557
71MP0005360_urolithiasis1.24426536
72MP0002127_abnormal_cardiovascular_syste1.22418017
73MP0001879_abnormal_lymphatic_vessel1.21935553
74MP0002108_abnormal_muscle_morphology1.21377786
75MP0001851_eye_inflammation1.20831894
76MP0005409_darkened_coat_color1.20790778
77MP0005387_immune_system_phenotype1.20404966
78MP0001790_abnormal_immune_system1.20404966
79MP0003763_abnormal_thymus_physiology1.18926931
80MP0009785_altered_susceptibility_to1.17631113
81MP0003279_aneurysm1.16909469
82MP0003195_calcinosis1.16713243
83MP0002118_abnormal_lipid_homeostasis1.16267240
84MP0001533_abnormal_skeleton_physiology1.15055895
85MP0009115_abnormal_fat_cell1.14630390
86MP0000733_abnormal_muscle_development1.14290345
87MP0002078_abnormal_glucose_homeostasis1.13343228
88MP0005025_abnormal_response_to1.11658016
89MP0005000_abnormal_immune_tolerance1.11365818
90MP0003453_abnormal_keratinocyte_physiol1.10765066
91MP0000685_abnormal_immune_system1.10760025
92MP0001800_abnormal_humoral_immune1.09906912
93MP0005076_abnormal_cell_differentiation1.09530674
94MP0009384_cardiac_valve_regurgitation1.08945569
95MP0003172_abnormal_lysosome_physiology1.08137142
96MP0010352_gastrointestinal_tract_polyps1.07750504
97MP0003191_abnormal_cellular_cholesterol1.07627819
98MP0004947_skin_inflammation1.07302857
99MP0005334_abnormal_fat_pad1.06435211
100MP0003137_abnormal_impulse_conducting1.05026202
101MP0002009_preneoplasia1.04411166
102MP0005166_decreased_susceptibility_to1.02403151
103MP0003221_abnormal_cardiomyocyte_apopto1.00836366
104MP0000609_abnormal_liver_physiology0.98175329
105MP0002452_abnormal_antigen_presenting0.98074656
106MP0005623_abnormal_meninges_morphology0.97466734
107MP0003950_abnormal_plasma_membrane0.97157697
108MP0003075_altered_response_to0.96925319
109MP0002723_abnormal_immune_serum0.95650413
110MP0005165_increased_susceptibility_to0.94971540
111MP0004085_abnormal_heartbeat0.94918663
112MP0002332_abnormal_exercise_endurance0.94317322
113MP0004043_abnormal_pH_regulation0.93816153
114MP0008260_abnormal_autophagy0.93589273
115MP0002896_abnormal_bone_mineralization0.93174455
116MP0006054_spinal_hemorrhage0.93156893
117MP0005058_abnormal_lysosome_morphology0.92983615
118MP0010678_abnormal_skin_adnexa0.92494417
119MP0002060_abnormal_skin_morphology0.92458689
120MP0002405_respiratory_system_inflammati0.92275500
121MP0000343_altered_response_to0.91085927
122MP0005187_abnormal_penis_morphology0.88249742
123MP0002006_tumorigenesis0.88073876
124MP0001661_extended_life_span0.87969679
125MP0002133_abnormal_respiratory_system0.87894201
126MP0005388_respiratory_system_phenotype0.87894201
127MP0004381_abnormal_hair_follicle0.87543831
128MP0000249_abnormal_blood_vessel0.87504558
129MP0002168_other_aberrant_phenotype0.87475093
130MP0002148_abnormal_hypersensitivity_rea0.86671421
131MP0003091_abnormal_cell_migration0.85923562
132MP0010155_abnormal_intestine_physiology0.84646630
133MP0000266_abnormal_heart_morphology0.84480103
134MP0008875_abnormal_xenobiotic_pharmacok0.84299332
135MP0005319_abnormal_enzyme/_coenzyme0.82374370
136MP0002128_abnormal_blood_circulation0.81669272
137MP0005535_abnormal_body_temperature0.80309665
138MP0001958_emphysema0.76234946
139MP0002234_abnormal_pharynx_morphology0.75925406
140MP0005503_abnormal_tendon_morphology0.75552276
141MP0003567_abnormal_fetal_cardiomyocyte0.71817873
142MP0005332_abnormal_amino_acid0.71668384
143MP0009643_abnormal_urine_homeostasis0.71315773
144MP0001944_abnormal_pancreas_morphology0.71250922
145MP0001299_abnormal_eye_distance/0.71224931
146MP0000230_abnormal_systemic_arterial0.69887047
147MP0000767_abnormal_smooth_muscle0.68733537
148MP0002295_abnormal_pulmonary_circulatio0.68214068
149MP0001666_abnormal_nutrient_absorption0.68212605

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.64179973
2Exercise-induced muscle cramps (HP:0003710)4.43038605
3Sudden death (HP:0001699)4.40715257
4Hyporeflexia of lower limbs (HP:0002600)4.39232282
5Myoglobinuria (HP:0002913)4.18152131
6Muscle fiber splitting (HP:0003555)4.11370808
7Increased connective tissue (HP:0009025)3.97826055
8Right ventricular cardiomyopathy (HP:0011663)3.93962960
9Hypoglycemic coma (HP:0001325)3.91661023
10Calf muscle hypertrophy (HP:0008981)3.73182885
11Difficulty running (HP:0009046)3.66939821
12Eczematoid dermatitis (HP:0000976)3.62176001
13Type 1 muscle fiber predominance (HP:0003803)3.52353687
14Muscle hypertrophy of the lower extremities (HP:0008968)3.49254554
15Subaortic stenosis (HP:0001682)3.47182187
16Abnormality of the left ventricular outflow tract (HP:0011103)3.47182187
17Ventricular tachycardia (HP:0004756)3.44330690
18Asymmetric septal hypertrophy (HP:0001670)3.39319197
19Ketoacidosis (HP:0001993)3.39167940
20Hyperglycemia (HP:0003074)3.23235132
21Abnormality of the calf musculature (HP:0001430)3.16428302
22Insulin-resistant diabetes mellitus (HP:0000831)3.02942472
23Lipoatrophy (HP:0100578)3.00930710
24Cerebral aneurysm (HP:0004944)2.99435602
25Bundle branch block (HP:0011710)2.97815846
26Recurrent bacterial skin infections (HP:0005406)2.89454717
27Distal lower limb muscle weakness (HP:0009053)2.89075106
28Atrial fibrillation (HP:0005110)2.81606443
29Rhabdomyolysis (HP:0003201)2.79891472
30Difficulty climbing stairs (HP:0003551)2.76177293
31Muscle fiber inclusion bodies (HP:0100299)2.74585845
32Recurrent gram-negative bacterial infections (HP:0005420)2.72996163
33Spontaneous hematomas (HP:0007420)2.71287791
34Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.69974702
35Hyperinsulinemic hypoglycemia (HP:0000825)2.69336948
36Hypoalphalipoproteinemia (HP:0003233)2.69156263
37EMG: myopathic abnormalities (HP:0003458)2.68808802
38Recurrent abscess formation (HP:0002722)2.66945905
39Ketosis (HP:0001946)2.66003790
40Primary atrial arrhythmia (HP:0001692)2.55566102
41Syncope (HP:0001279)2.54892513
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.46134459
43Ventricular arrhythmia (HP:0004308)2.45964165
44Gingivitis (HP:0000230)2.45610357
45Atrioventricular block (HP:0001678)2.45506562
46Mildly elevated creatine phosphokinase (HP:0008180)2.43701352
47Dilated cardiomyopathy (HP:0001644)2.42051722
48Papillary thyroid carcinoma (HP:0002895)2.42045567
49Increased variability in muscle fiber diameter (HP:0003557)2.41520192
50Aneurysm (HP:0002617)2.36440751
51Broad metatarsal (HP:0001783)2.34973496
52Supraventricular arrhythmia (HP:0005115)2.34161873
53Myocardial infarction (HP:0001658)2.32912025
54Myotonia (HP:0002486)2.31526667
55Supraventricular tachycardia (HP:0004755)2.31381072
56Gingival bleeding (HP:0000225)2.30729292
57Abnormality of macrophages (HP:0004311)2.30587176
58Abnormal atrioventricular conduction (HP:0005150)2.28922052
59Hypoplastic ischia (HP:0003175)2.28130139
60Orchitis (HP:0100796)2.28053298
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.27451583
62Osteolytic defects of the hand bones (HP:0009699)2.27451583
63Myositis (HP:0100614)2.26538247
64Heart block (HP:0012722)2.26164567
65Facial diplegia (HP:0001349)2.25861404
66Palpitations (HP:0001962)2.23590832
67Abnormality of skeletal muscle fiber size (HP:0012084)2.23039216
68Hypoglycemic seizures (HP:0002173)2.20649580
69Prolonged QT interval (HP:0001657)2.20431953
70Lymphangioma (HP:0100764)2.20173691
71Spinal rigidity (HP:0003306)2.19312939
72Hematochezia (HP:0002573)2.16773163
73Skin nodule (HP:0200036)2.16651048
74Arterial tortuosity (HP:0005116)2.15928527
75Retrobulbar optic neuritis (HP:0100654)2.15916938
76Optic neuritis (HP:0100653)2.15916938
77Scapular winging (HP:0003691)2.15282054
78Abnormality of the ischium (HP:0003174)2.14637058
79Polycythemia (HP:0001901)2.13776236
80Pancreatic islet-cell hyperplasia (HP:0004510)2.13079721
81Distal arthrogryposis (HP:0005684)2.11207379
82Aortic aneurysm (HP:0004942)2.11111213
83Round ear (HP:0100830)2.08752888
84Aortic dissection (HP:0002647)2.08005116
85Xanthomatosis (HP:0000991)2.07044001
86Oligomenorrhea (HP:0000876)2.06327113
87Macroorchidism (HP:0000053)2.05121353
88Abnormality of fatty-acid metabolism (HP:0004359)2.04157672
89Nemaline bodies (HP:0003798)2.03488434
90Muscle stiffness (HP:0003552)2.02751730
91Hamartoma of the eye (HP:0010568)2.02137001
92Gastrointestinal infarctions (HP:0005244)2.01133531
93Interstitial pulmonary disease (HP:0006530)1.99787894
94Vascular tortuosity (HP:0004948)1.99302456
95Hyperkalemia (HP:0002153)1.99037397
96Protrusio acetabuli (HP:0003179)1.98489651
97Premature rupture of membranes (HP:0001788)1.97852327
98Hyperglycinuria (HP:0003108)1.97846873
99Amyloidosis (HP:0011034)1.97336151
100Subacute progressive viral hepatitis (HP:0006572)1.97107189
101Large for gestational age (HP:0001520)1.95300867
102Conjunctival hamartoma (HP:0100780)1.95081505
103Arterial thrombosis (HP:0004420)1.94963595
104Peritonitis (HP:0002586)1.94501319
105Ventricular fibrillation (HP:0001663)1.93790529
106Acanthosis nigricans (HP:0000956)1.93520283
107Areflexia of lower limbs (HP:0002522)1.92771493
108Frequent falls (HP:0002359)1.90587098
109Deep venous thrombosis (HP:0002625)1.90404268
110Keratoconjunctivitis sicca (HP:0001097)1.88841131
111Neck muscle weakness (HP:0000467)1.88451883
112Colitis (HP:0002583)1.87201556
113Insulin resistance (HP:0000855)1.86932307
114Distal lower limb amyotrophy (HP:0008944)1.86653140
115Chest pain (HP:0100749)1.85994283
116Prolonged bleeding time (HP:0003010)1.85488168
117Abnormality of the common coagulation pathway (HP:0010990)1.84047190
118Mitral stenosis (HP:0001718)1.83007936
119Mitral valve prolapse (HP:0001634)1.82801283
120Ulnar deviation of the wrist (HP:0003049)1.81810617
121EMG: neuropathic changes (HP:0003445)1.80693615
122Dilatation of the ascending aorta (HP:0005111)1.80509709
123Spondylolisthesis (HP:0003302)1.80420989
124T lymphocytopenia (HP:0005403)1.78350528
125Dysmetric saccades (HP:0000641)1.75881495
126Complement deficiency (HP:0004431)1.75398036
127Pigmentary retinal degeneration (HP:0001146)1.75333116
128Abnormality of endocrine pancreas physiology (HP:0012093)1.75258939
129Abnormality of the pancreatic islet cells (HP:0006476)1.75258939
130Recurrent skin infections (HP:0001581)1.75106223
131Rectal prolapse (HP:0002035)1.74815555
132Gowers sign (HP:0003391)1.73913357
133Ankle contracture (HP:0006466)1.73812659
134Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73181669
135Periodontitis (HP:0000704)1.72928261
136Popliteal pterygium (HP:0009756)1.71757462
137Proximal amyotrophy (HP:0007126)1.71719355
138Increased IgE level (HP:0003212)1.71641923
139Hyperammonemia (HP:0001987)1.70822743
140Increased CSF protein (HP:0002922)1.70712112
141Gout (HP:0001997)1.70388062
142Abnormality of the fingertips (HP:0001211)1.69746306
143Epistaxis (HP:0000421)1.67632742
144Striae distensae (HP:0001065)1.64725736
145Autoimmune hemolytic anemia (HP:0001890)1.64088407
146Abnormality of T cell number (HP:0011839)1.62824386
147Rimmed vacuoles (HP:0003805)1.62703251
148Keratoconjunctivitis (HP:0001096)1.61430399
149Malnutrition (HP:0004395)1.59027448
150Mediastinal lymphadenopathy (HP:0100721)1.58641060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.81380751
2TTN3.25584540
3OBSCN2.63019651
4PKN22.49675986
5RIPK12.47568062
6FRK2.45236095
7PDK42.31741970
8PDK32.31741970
9LATS12.26919213
10SIK12.25475622
11BLK2.18073254
12INSRR2.12011825
13PDGFRA1.92680210
14DMPK1.91129699
15RIPK41.89492208
16PHKG21.75908437
17PHKG11.75908437
18CAMK1D1.69913817
19PRKD31.67544414
20PDK21.58332838
21AKT31.57717157
22NLK1.57486258
23EPHA31.55481236
24FGFR31.53988708
25PTK61.50525184
26FGFR41.48385875
27LMTK21.44361750
28MAP3K141.42809702
29PRPF4B1.42595160
30TIE11.39152140
31BCKDK1.38868581
32ERN11.36671144
33FGFR21.34559894
34MAP3K31.31753235
35ZAP701.31294975
36CAMK1G1.31208230
37TGFBR21.21422829
38MAP2K31.21184734
39MAP3K21.20980747
40JAK11.19467963
41PIK3CA1.18465100
42STK241.18096498
43NEK91.13813133
44FLT31.08105429
45BMPR21.07838235
46DDR21.07768201
47PRKAA21.07156971
48PRKCH1.03443934
49IRAK11.02703220
50CDK61.02378636
51STK31.01118780
52MAP3K71.00754818
53MUSK1.00618718
54PRKAA11.00015968
55MAPK70.99135660
56HCK0.97958320
57PINK10.97471384
58EPHB10.97450749
59FES0.96860965
60TRPM70.96603373
61MST1R0.95997506
62IKBKE0.92716078
63PRKD10.92681175
64FGR0.92293947
65RET0.91635864
66GRK70.90730147
67BTK0.89707327
68PDGFRB0.89190231
69FER0.86527539
70SGK4940.85629241
71SGK2230.85629241
72CDC42BPA0.83920464
73SGK30.83113377
74SYK0.82433941
75MARK20.82109972
76JAK20.81981870
77MYLK0.81521207
78TEC0.80961097
79MTOR0.80066053
80MAP3K130.80043891
81KSR20.78629620
82CAMK40.78183241
83CSF1R0.76090379
84ICK0.75770336
85YES10.75764215
86IRAK40.74561494
87WNK40.74149234
88MAP2K40.73874546
89PAK30.73593007
90TAOK30.73257271
91MAP3K100.73136699
92HIPK20.73086126
93BMX0.71965537
94PDPK10.69352682
95PIK3CG0.68895545
96GSK3A0.67006541
97FGFR10.66112194
98SCYL20.65752729
99WNK10.64854332
100DYRK1B0.64497192
101PDK10.62676333
102MAP3K60.61933426
103PTK20.61821363
104MAP3K50.61406310
105IRAK20.60084021
106ITK0.59098672
107TAOK10.58930637
108MAPK150.58238775
109KIT0.57320856
110NEK10.56551339
111PRKD20.56391797
112ERBB30.56153471
113MAP3K10.53355561
114LCK0.51928413
115STK380.48522832
116NUAK10.48212531
117SGK20.47774516
118MAPK120.46586849
119EEF2K0.46522269
120BRD40.46315940
121MAP4K10.46245629
122CSK0.45816598
123LYN0.45761625
124STK100.45694835
125MAPK40.45401022
126TYK20.44243086
127PAK20.44239554
128MOS0.42813098
129JAK30.42303837
130MAPK110.39991535
131PTK2B0.39572226
132MET0.39239472
133PRKACG0.37579076
134MELK0.37563585
135SGK10.36768631
136ILK0.36579355
137TBK10.35951268
138STK38L0.35662075
139LRRK20.35505079
140MAP2K10.34855481
141ROCK10.34493726
142CAMKK20.33689442

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.15216576
2Propanoate metabolism_Homo sapiens_hsa006402.54564972
3Fatty acid degradation_Homo sapiens_hsa000712.51434294
4Fatty acid metabolism_Homo sapiens_hsa012122.18876069
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12102347
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.10233945
7Nitrogen metabolism_Homo sapiens_hsa009102.04842913
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01758105
9PPAR signaling pathway_Homo sapiens_hsa033201.97750782
10Dilated cardiomyopathy_Homo sapiens_hsa054141.96971746
11Fatty acid biosynthesis_Homo sapiens_hsa000611.95716313
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.92235635
13Insulin resistance_Homo sapiens_hsa049311.80680761
14Leishmaniasis_Homo sapiens_hsa051401.68984574
15Adipocytokine signaling pathway_Homo sapiens_hsa049201.68925984
16Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.65027708
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54560626
18Arginine biosynthesis_Homo sapiens_hsa002201.45624770
19B cell receptor signaling pathway_Homo sapiens_hsa046621.44540946
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.42864060
21Type II diabetes mellitus_Homo sapiens_hsa049301.41086383
22Malaria_Homo sapiens_hsa051441.40272280
23Glucagon signaling pathway_Homo sapiens_hsa049221.36216182
24Tuberculosis_Homo sapiens_hsa051521.32045655
25Starch and sucrose metabolism_Homo sapiens_hsa005001.29918447
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28195081
27AMPK signaling pathway_Homo sapiens_hsa041521.27443655
28Insulin signaling pathway_Homo sapiens_hsa049101.24916204
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23212839
30Carbon metabolism_Homo sapiens_hsa012001.22599912
31Focal adhesion_Homo sapiens_hsa045101.21395912
32Tryptophan metabolism_Homo sapiens_hsa003801.19948961
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.18280153
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.15682753
35Circadian rhythm_Homo sapiens_hsa047101.13008713
36Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13006176
37mTOR signaling pathway_Homo sapiens_hsa041501.12593215
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12510358
39Adherens junction_Homo sapiens_hsa045201.09957228
40Lysine degradation_Homo sapiens_hsa003101.08975454
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08714953
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08540603
43Non-small cell lung cancer_Homo sapiens_hsa052231.07147003
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06699261
45TNF signaling pathway_Homo sapiens_hsa046681.06282163
46Pancreatic cancer_Homo sapiens_hsa052121.06033714
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04470187
48Butanoate metabolism_Homo sapiens_hsa006501.04317528
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03442569
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99436730
51ECM-receptor interaction_Homo sapiens_hsa045120.99075351
52Pyruvate metabolism_Homo sapiens_hsa006200.97531583
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.97489505
54Chemokine signaling pathway_Homo sapiens_hsa040620.95130709
55Inositol phosphate metabolism_Homo sapiens_hsa005620.94050669
56Legionellosis_Homo sapiens_hsa051340.92540047
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92520816
58T cell receptor signaling pathway_Homo sapiens_hsa046600.92286333
59Viral myocarditis_Homo sapiens_hsa054160.92248465
60Measles_Homo sapiens_hsa051620.91979054
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.91846295
62Influenza A_Homo sapiens_hsa051640.91574519
63Other glycan degradation_Homo sapiens_hsa005110.90459302
64Amoebiasis_Homo sapiens_hsa051460.90098479
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89736401
66ABC transporters_Homo sapiens_hsa020100.88653283
67Dorso-ventral axis formation_Homo sapiens_hsa043200.87981108
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.87327749
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87281079
70Pertussis_Homo sapiens_hsa051330.86498954
71Bile secretion_Homo sapiens_hsa049760.85528109
72Hepatitis C_Homo sapiens_hsa051600.85301500
73Hematopoietic cell lineage_Homo sapiens_hsa046400.84667366
74Proteoglycans in cancer_Homo sapiens_hsa052050.80673312
75beta-Alanine metabolism_Homo sapiens_hsa004100.80583157
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80098403
77Complement and coagulation cascades_Homo sapiens_hsa046100.79720702
78Graft-versus-host disease_Homo sapiens_hsa053320.79569752
79Glycerolipid metabolism_Homo sapiens_hsa005610.77672913
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.76801149
81Sulfur metabolism_Homo sapiens_hsa009200.76151302
82Caffeine metabolism_Homo sapiens_hsa002320.76114877
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.75675542
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75143649
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74429076
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74031049
87Hepatitis B_Homo sapiens_hsa051610.73536512
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.73400517
89Phagosome_Homo sapiens_hsa041450.73350332
90Allograft rejection_Homo sapiens_hsa053300.73013955
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72707145
92Fat digestion and absorption_Homo sapiens_hsa049750.72614106
93Choline metabolism in cancer_Homo sapiens_hsa052310.71550455
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70834594
95Long-term potentiation_Homo sapiens_hsa047200.70651239
96ErbB signaling pathway_Homo sapiens_hsa040120.69437077
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69166583
98Pancreatic secretion_Homo sapiens_hsa049720.68087784
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67990316
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67595916
101Cardiac muscle contraction_Homo sapiens_hsa042600.66898137
102Autoimmune thyroid disease_Homo sapiens_hsa053200.66452740
103Small cell lung cancer_Homo sapiens_hsa052220.65771213
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64448329
105Toxoplasmosis_Homo sapiens_hsa051450.63663959
106Insulin secretion_Homo sapiens_hsa049110.62834215
107FoxO signaling pathway_Homo sapiens_hsa040680.61693473
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.61155598
109Renin secretion_Homo sapiens_hsa049240.60751588
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60539467
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60159266
112Type I diabetes mellitus_Homo sapiens_hsa049400.59644004
113Prolactin signaling pathway_Homo sapiens_hsa049170.58558058
114Phenylalanine metabolism_Homo sapiens_hsa003600.58195753
115MAPK signaling pathway_Homo sapiens_hsa040100.58182667
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57934520
117Chronic myeloid leukemia_Homo sapiens_hsa052200.57866681
118Peroxisome_Homo sapiens_hsa041460.57174494
119Salmonella infection_Homo sapiens_hsa051320.56703873
120Protein digestion and absorption_Homo sapiens_hsa049740.56606977
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53770325
122Staphylococcus aureus infection_Homo sapiens_hsa051500.52801961
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.52466025
124Platelet activation_Homo sapiens_hsa046110.51175214
125Tight junction_Homo sapiens_hsa045300.50287654
126HIF-1 signaling pathway_Homo sapiens_hsa040660.49506079
127Selenocompound metabolism_Homo sapiens_hsa004500.46092376
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45990458
129Renal cell carcinoma_Homo sapiens_hsa052110.45211724
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.44907292
131Oxytocin signaling pathway_Homo sapiens_hsa049210.44466579
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43724720
133Thyroid hormone synthesis_Homo sapiens_hsa049180.43247604
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42932713
135Estrogen signaling pathway_Homo sapiens_hsa049150.41293114
136Biosynthesis of amino acids_Homo sapiens_hsa012300.40281862
137VEGF signaling pathway_Homo sapiens_hsa043700.38544046
138GnRH signaling pathway_Homo sapiens_hsa049120.38175434
139Osteoclast differentiation_Homo sapiens_hsa043800.35697160
140cAMP signaling pathway_Homo sapiens_hsa040240.35352824
141Ovarian steroidogenesis_Homo sapiens_hsa049130.35282580
142Prostate cancer_Homo sapiens_hsa052150.34109207
143Acute myeloid leukemia_Homo sapiens_hsa052210.33834868
144Glioma_Homo sapiens_hsa052140.33783730
145Endometrial cancer_Homo sapiens_hsa052130.33704766
146Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33269087
147Lysosome_Homo sapiens_hsa041420.32820465
148Gastric acid secretion_Homo sapiens_hsa049710.32280167

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