HILPDA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.93692933
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.12621347
3cellular response to zinc ion (GO:0071294)5.29376220
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.24147143
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.58005250
6ATP synthesis coupled proton transport (GO:0015986)4.58005250
7chaperone-mediated protein transport (GO:0072321)4.53729494
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.49381148
9proteasome assembly (GO:0043248)4.44912826
10production of molecular mediator involved in inflammatory response (GO:0002532)4.39889891
11viral transcription (GO:0019083)4.26890732
12translational termination (GO:0006415)4.24989319
13regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.24409665
14gamma-aminobutyric acid transport (GO:0015812)4.23496178
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.21838831
16neutrophil activation (GO:0042119)4.13246504
17granulocyte activation (GO:0036230)4.10151248
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.03229448
19cotranslational protein targeting to membrane (GO:0006613)4.00610609
20protein targeting to ER (GO:0045047)3.91954986
21myeloid dendritic cell activation (GO:0001773)3.87381174
22respiratory electron transport chain (GO:0022904)3.83376250
23electron transport chain (GO:0022900)3.80132409
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.75132260
25protein localization to endoplasmic reticulum (GO:0070972)3.72678135
26response to protozoan (GO:0001562)3.65189329
27respiratory burst (GO:0045730)3.61614889
28cellular response to cadmium ion (GO:0071276)3.59029896
29positive regulation of chemokine secretion (GO:0090197)3.55280179
30translational elongation (GO:0006414)3.54539905
31response to peptidoglycan (GO:0032494)3.53992831
32positive regulation of macrophage differentiation (GO:0045651)3.52265405
33myeloid dendritic cell differentiation (GO:0043011)3.51372220
34chromatin remodeling at centromere (GO:0031055)3.51277714
35superoxide anion generation (GO:0042554)3.50657538
36protein complex biogenesis (GO:0070271)3.48491113
37positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.44919389
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.44754662
39NADH dehydrogenase complex assembly (GO:0010257)3.44754662
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.44754662
41myeloid cell activation involved in immune response (GO:0002275)3.41906371
42positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.40122685
43CENP-A containing nucleosome assembly (GO:0034080)3.36492646
44regulation of fever generation (GO:0031620)3.29083284
45mitochondrial respiratory chain complex assembly (GO:0033108)3.27077833
46lateral sprouting from an epithelium (GO:0060601)3.25885214
47response to muramyl dipeptide (GO:0032495)3.25512309
48immunoglobulin mediated immune response (GO:0016064)3.25145493
49eosinophil chemotaxis (GO:0048245)3.25105782
50lipopolysaccharide-mediated signaling pathway (GO:0031663)3.23927474
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.23032905
52hydrogen peroxide biosynthetic process (GO:0050665)3.22454931
53positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.20754256
54regulation of interleukin-12 biosynthetic process (GO:0045075)3.19241886
55ribosomal large subunit biogenesis (GO:0042273)3.17593881
56viral life cycle (GO:0019058)3.14886579
57cellular protein complex disassembly (GO:0043624)3.14571487
58positive regulation of interferon-alpha production (GO:0032727)3.13943695
59branching involved in labyrinthine layer morphogenesis (GO:0060670)3.13379484
60translational initiation (GO:0006413)3.13079503
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12763790
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12763790
63sequestering of actin monomers (GO:0042989)3.11308522
64defense response to protozoan (GO:0042832)3.11092605
65positive regulation of mast cell degranulation (GO:0043306)3.10143296
66positive regulation of mast cell activation involved in immune response (GO:0033008)3.10143296
67NIK/NF-kappaB signaling (GO:0038061)3.10136641
68cellular extravasation (GO:0045123)3.08953617
69maturation of SSU-rRNA (GO:0030490)3.08461649
70negative regulation of myeloid cell apoptotic process (GO:0033033)3.07699863
71positive regulation of p38MAPK cascade (GO:1900745)3.06992835
72platelet dense granule organization (GO:0060155)3.05601731
73inner mitochondrial membrane organization (GO:0007007)3.05582390
74protein neddylation (GO:0045116)3.04762900
75positive regulation of heat generation (GO:0031652)3.03813276
764-hydroxyproline metabolic process (GO:0019471)3.03636527
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03016806
78monocyte chemotaxis (GO:0002548)3.02669379
79interferon-gamma production (GO:0032609)3.01920134
80positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.01144312
81positive regulation of monocyte chemotaxis (GO:0090026)2.99947913
82translation (GO:0006412)2.99939285
83regulation of mast cell degranulation (GO:0043304)2.99834750
84leukocyte aggregation (GO:0070486)2.99481409
85cranial suture morphogenesis (GO:0060363)2.99088334
86regulation of interferon-alpha production (GO:0032647)2.98889024
87modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.96823023
88positive regulation by organism of defense response of other organism involved in symbiotic interact2.96823023
89modulation by symbiont of host immune response (GO:0052553)2.96823023
90positive regulation by symbiont of host defense response (GO:0052509)2.96823023
91modulation by symbiont of host defense response (GO:0052031)2.96823023
92modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.96823023
93lipoxygenase pathway (GO:0019372)2.96654141
94positive regulation of interleukin-10 production (GO:0032733)2.96586467
95regulation of interferon-beta biosynthetic process (GO:0045357)2.96048821
96regulation of mast cell activation (GO:0033003)2.95729267
97negative regulation of mast cell activation (GO:0033004)2.95474884
98wound healing, spreading of epidermal cells (GO:0035313)2.94463950
99response to interferon-beta (GO:0035456)2.92612929
100exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92442898
101reactive oxygen species biosynthetic process (GO:1903409)2.92167825
102leukocyte mediated cytotoxicity (GO:0001909)2.91245239
103regulation of B cell receptor signaling pathway (GO:0050855)2.89959289
104positive regulation of mast cell activation (GO:0033005)2.89111211
105ribosomal small subunit assembly (GO:0000028)2.88958139
106ribosomal small subunit biogenesis (GO:0042274)2.88833222
107positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.88238349
108myeloid leukocyte activation (GO:0002274)2.88223542
109regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.87827719
110natural killer cell mediated immunity (GO:0002228)2.87154001
111natural killer cell mediated cytotoxicity (GO:0042267)2.87154001
112T-helper 1 type immune response (GO:0042088)2.86537202
113regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.86129334
114transcription elongation from RNA polymerase III promoter (GO:0006385)2.85227185
115termination of RNA polymerase III transcription (GO:0006386)2.85227185
116positive regulation of chemokine biosynthetic process (GO:0045080)2.85098933
117mast cell activation (GO:0045576)2.85068294
118eosinophil migration (GO:0072677)2.81633628
119negative regulation of interleukin-17 production (GO:0032700)2.80219590
120negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.79950763
121epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79707292
122regulation of mast cell activation involved in immune response (GO:0033006)2.78576358
123macrophage activation involved in immune response (GO:0002281)2.78565793
124positive regulation of antigen processing and presentation (GO:0002579)2.78411358
125protein-cofactor linkage (GO:0018065)2.77098009
126cullin deneddylation (GO:0010388)2.76006373
127regulation of mononuclear cell migration (GO:0071675)2.73897161
128rRNA modification (GO:0000154)2.73347272
129positive regulation of chemokine production (GO:0032722)2.72899194
130positive regulation of lymphocyte migration (GO:2000403)2.72802274
131protein complex disassembly (GO:0043241)2.70336918
132otic vesicle formation (GO:0030916)2.69818591
133phagosome maturation (GO:0090382)2.69786284
134telomere maintenance via semi-conservative replication (GO:0032201)2.69689492
135histone exchange (GO:0043486)2.69353644
136positive regulation of interferon-gamma production (GO:0032729)2.68907338
137positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.67707695
138regulation of macrophage differentiation (GO:0045649)2.67150012
139nonmotile primary cilium assembly (GO:0035058)2.67053101
140positive regulation of interleukin-6 production (GO:0032755)2.66989523
141modulation by symbiont of host cellular process (GO:0044068)2.66339627
142positive regulation of T cell migration (GO:2000406)2.65881500
143detection of molecule of bacterial origin (GO:0032490)2.65768047
144positive regulation of acute inflammatory response (GO:0002675)2.65738536
145positive regulation of NF-kappaB import into nucleus (GO:0042346)2.65452999
146positive regulation of interleukin-1 beta secretion (GO:0050718)2.64710261
147protein targeting to mitochondrion (GO:0006626)2.64630569
148regulation of RIG-I signaling pathway (GO:0039535)2.64603516
149positive regulation of tumor necrosis factor production (GO:0032760)2.64470882
150regulation of antigen processing and presentation (GO:0002577)2.63190337
151negative regulation of lipid storage (GO:0010888)2.61371894
152macrophage activation (GO:0042116)2.59775260
153positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.59757581
154peptidyl-proline hydroxylation (GO:0019511)2.59669527
155intracellular protein transmembrane import (GO:0044743)2.59596501
156antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.59173356
157regulation of B cell differentiation (GO:0045577)2.59149034
158positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.59126879
159positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.58916813
160macromolecular complex disassembly (GO:0032984)2.58641224
161positive regulation of interleukin-12 production (GO:0032735)2.58360603
162lung vasculature development (GO:0060426)2.57190717
163nuclear-transcribed mRNA catabolic process (GO:0000956)2.56857682
164ATP biosynthetic process (GO:0006754)2.56573511
165DNA catabolic process, exonucleolytic (GO:0000738)2.56128179
166regulation of chemokine biosynthetic process (GO:0045073)2.55981722
167protein K6-linked ubiquitination (GO:0085020)2.55974626
168regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.54117539
169spliceosomal snRNP assembly (GO:0000387)2.53557961
170establishment of protein localization to mitochondrion (GO:0072655)2.53402200
171dopaminergic neuron differentiation (GO:0071542)2.53272022
172negative regulation of ligase activity (GO:0051352)2.52247551
173negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.52247551
174aldehyde catabolic process (GO:0046185)2.51348157
175hydrogen ion transmembrane transport (GO:1902600)2.51328474
176DNA strand elongation involved in DNA replication (GO:0006271)2.50848283
177behavioral response to nicotine (GO:0035095)2.50633620
178protein localization to mitochondrion (GO:0070585)2.50501971
179protein targeting to membrane (GO:0006612)2.50411460
180water-soluble vitamin biosynthetic process (GO:0042364)2.48591925
181DNA damage response, detection of DNA damage (GO:0042769)2.45685617
182positive regulation of mitochondrial fission (GO:0090141)2.44942921
183positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44354426
184pyrimidine nucleobase catabolic process (GO:0006208)2.43071674
185anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.42946187
186kinetochore assembly (GO:0051382)2.42812160
187mRNA catabolic process (GO:0006402)2.42406796
188cellular component biogenesis (GO:0044085)2.42103962
189positive regulation of protein kinase C signaling (GO:0090037)2.42091043
190DNA replication checkpoint (GO:0000076)2.41649322
191protein deneddylation (GO:0000338)2.40808314
192purine nucleoside triphosphate biosynthetic process (GO:0009145)2.40483334
193oxidative phosphorylation (GO:0006119)2.40401627
194resolution of meiotic recombination intermediates (GO:0000712)2.39703531
195pseudouridine synthesis (GO:0001522)2.39432270
196purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.39392389
197epithelial cilium movement (GO:0003351)2.38690679
198somite development (GO:0061053)2.37914415

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.02015208
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.05610545
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.46624783
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.00121267
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.63114032
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.47046280
7MYB_21317192_ChIP-Seq_ERMYB_Mouse3.45402842
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.42828735
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.40020861
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.33042647
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.29449669
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.18159803
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01315646
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.96834654
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.90765756
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85327684
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.83992235
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.81791238
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.78984546
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73997752
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.66777632
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57226948
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53916444
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48329083
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.42297845
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36996211
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31650846
28NOTCH1_21737748_ChIP-Seq_TLL_Human2.29323050
29ZNF274_21170338_ChIP-Seq_K562_Hela2.24039016
30SPI1_23547873_ChIP-Seq_NB4_Human2.23313021
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19131728
32SCL_19346495_ChIP-Seq_HPC-7_Human2.18969810
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18875209
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.12774444
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11137270
36RUNX_20019798_ChIP-Seq_JUKART_Human2.07720814
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04829074
38RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04171625
39VDR_22108803_ChIP-Seq_LS180_Human1.95649124
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92241710
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90971047
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82777022
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82616318
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.82266997
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82044158
46MYB_26560356_Chip-Seq_TH2_Human1.80831964
47E2F7_22180533_ChIP-Seq_HELA_Human1.80339152
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78338545
49VDR_24763502_ChIP-Seq_THP-1_Human1.77222186
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76212848
51MYC_18940864_ChIP-ChIP_HL60_Human1.76025889
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74281344
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72163025
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.69408497
55TTF2_22483619_ChIP-Seq_HELA_Human1.68986544
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.68494861
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66797958
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66012548
59EWS_26573619_Chip-Seq_HEK293_Human1.65443838
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64888440
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64640548
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64335217
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62784936
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.61538151
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59701009
66FUS_26573619_Chip-Seq_HEK293_Human1.58050605
67VDR_24787735_ChIP-Seq_THP-1_Human1.57794097
68ELK1_19687146_ChIP-ChIP_HELA_Human1.57743164
69AR_21909140_ChIP-Seq_LNCAP_Human1.57165605
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55713062
71XRN2_22483619_ChIP-Seq_HELA_Human1.54725381
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52853480
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52696073
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52256068
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50494414
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49563608
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49497669
78MAF_26560356_Chip-Seq_TH1_Human1.48345624
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47486516
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47048453
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46971450
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46508099
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45377754
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45118675
85FOXP3_21729870_ChIP-Seq_TREG_Human1.44688043
86ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.44250644
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.42939491
88TP63_17297297_ChIP-ChIP_HaCaT_Human1.42681495
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40738214
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39692159
91PU_27001747_Chip-Seq_BMDM_Mouse1.35647980
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33334891
93GABP_19822575_ChIP-Seq_HepG2_Human1.32490986
94ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32460583
95SOX2_16153702_ChIP-ChIP_HESCs_Human1.32054191
96SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30206220
97MYB_26560356_Chip-Seq_TH1_Human1.30091714
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.28919146
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27471344
100MYC_18555785_ChIP-Seq_MESCs_Mouse1.25905661
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25390523
102NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25318553
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24811575
104NANOG_16153702_ChIP-ChIP_HESCs_Human1.24343791
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.22140994
106CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21994746
107CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21557268
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21511084
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19260484
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17454011
111VDR_23849224_ChIP-Seq_CD4+_Human1.16873022
112KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14925533
113LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14168037
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14073217
115P300_19829295_ChIP-Seq_ESCs_Human1.13948328
116RNF2_27304074_Chip-Seq_NSC_Mouse1.13114466
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12023675
118FOXM1_23109430_ChIP-Seq_U2OS_Human1.11077875
119LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10844245
120GABP_17652178_ChIP-ChIP_JURKAT_Human1.10591613
121KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10061138
122KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10061138
123KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10061138
124ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08964297
125HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07952518
126ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07882983
127SPI1_23127762_ChIP-Seq_K562_Human1.06417904
128GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05923152
129CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05821334
130GATA3_27048872_Chip-Seq_THYMUS_Human1.05750684
131CBX2_27304074_Chip-Seq_ESCs_Mouse1.05291361
132ELK1_22589737_ChIP-Seq_MCF10A_Human1.04747633
133UTX_26944678_Chip-Seq_JUKART_Human1.04278331
134BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03362042
135ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02159264
136FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01956598
137VDR_21846776_ChIP-Seq_THP-1_Human1.01644533
138GBX2_23144817_ChIP-Seq_PC3_Human1.00806775
139ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00466998
140PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00245430
141GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99683865
142CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98863632
143YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98339856
144POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98162520
145CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97010758
146HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96151818
147E2F1_21310950_ChIP-Seq_MCF-7_Human0.95220777
148SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95188415
149SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95188415
150MYC_22102868_ChIP-Seq_BL_Human0.94573071
151PIAS1_25552417_ChIP-Seq_VCAP_Human0.93756660
152SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93689524
153MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92950521
154ELK3_25401928_ChIP-Seq_HUVEC_Human0.92615737
155PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91972143
156LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91052879
157CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90300472
158ESR1_21235772_ChIP-Seq_MCF-7_Human0.90171209
159GATA3_26560356_Chip-Seq_TH2_Human0.89906182
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89897014
161SALL1_21062744_ChIP-ChIP_HESCs_Human0.88339075
162DCP1A_22483619_ChIP-Seq_HELA_Human0.88165895
163PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88007479
164ZNF263_19887448_ChIP-Seq_K562_Human0.87834411
165POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87120372
166E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86779505
167SRF_21415370_ChIP-Seq_HL-1_Mouse0.86624993
168KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85976914
169SOX2_20726797_ChIP-Seq_SW620_Human0.84929269
170NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84409804
171TP53_22573176_ChIP-Seq_HFKS_Human0.83232795
172TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82747907
173TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82641162
174POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82610903
175SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82244597
176FLI1_27457419_Chip-Seq_LIVER_Mouse0.82063559
177THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81302754
178TAF15_26573619_Chip-Seq_HEK293_Human0.81202850
179CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80456469
180FOXA1_25329375_ChIP-Seq_VCAP_Human0.80258878
181FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80258878
182CLOCK_20551151_ChIP-Seq_293T_Human0.80251241
183JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80190944
184TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80142689
185NANOG_18555785_ChIP-Seq_MESCs_Mouse0.78005753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation5.08396469
2MP0001835_abnormal_antigen_presentation4.27557817
3MP0003724_increased_susceptibility_to3.92328992
4MP0002148_abnormal_hypersensitivity_rea3.74190292
5MP0003436_decreased_susceptibility_to3.73579611
6MP0010030_abnormal_orbit_morphology3.54763833
7MP0009785_altered_susceptibility_to3.28257963
8MP0005000_abnormal_immune_tolerance3.18473022
9MP0002419_abnormal_innate_immunity3.05525663
10MP0005671_abnormal_response_to2.77362932
11MP0005025_abnormal_response_to2.68299379
12MP0002452_abnormal_antigen_presenting2.66534272
13MP0003136_yellow_coat_color2.60342281
14MP0004510_myositis2.50438180
15MP0002723_abnormal_immune_serum2.48553093
16MP0006082_CNS_inflammation2.41083409
17MP0003950_abnormal_plasma_membrane2.40293202
18MP0003303_peritoneal_inflammation2.39775642
19MP0002138_abnormal_hepatobiliary_system2.38059971
20MP0001790_abnormal_immune_system2.37960515
21MP0005387_immune_system_phenotype2.37960515
22MP0001800_abnormal_humoral_immune2.37842549
23MP0001853_heart_inflammation2.37115747
24MP0000343_altered_response_to2.33739714
25MP0009379_abnormal_foot_pigmentation2.31362274
26MP0001819_abnormal_immune_cell2.30367378
27MP0002405_respiratory_system_inflammati2.30255843
28MP0002420_abnormal_adaptive_immunity2.28504757
29MP0003880_abnormal_central_pattern2.23457813
30MP0000685_abnormal_immune_system2.19547024
31MP0002938_white_spotting2.19234547
32MP0006292_abnormal_olfactory_placode2.13747616
33MP0001533_abnormal_skeleton_physiology2.11681190
34MP0000566_synostosis2.07439186
35MP0003448_altered_tumor_morphology2.02722384
36MP0004782_abnormal_surfactant_physiolog2.02718304
37MP0005464_abnormal_platelet_physiology1.95368586
38MP0006054_spinal_hemorrhage1.91429971
39MP0010155_abnormal_intestine_physiology1.82919772
40MP0001845_abnormal_inflammatory_respons1.81542830
41MP0009333_abnormal_splenocyte_physiolog1.81163149
42MP0000465_gastrointestinal_hemorrhage1.77515319
43MP0008789_abnormal_olfactory_epithelium1.75400271
44MP0008058_abnormal_DNA_repair1.74676921
45MP0009764_decreased_sensitivity_to1.71469966
46MP0001293_anophthalmia1.69584506
47MP0002736_abnormal_nociception_after1.67827295
48MP0003938_abnormal_ear_development1.67455533
49MP0002102_abnormal_ear_morphology1.66036643
50MP0000716_abnormal_immune_system1.65791367
51MP0003828_pulmonary_edema1.65775749
52MP0000049_abnormal_middle_ear1.63603084
53MP0005377_hearing/vestibular/ear_phenot1.62719015
54MP0003878_abnormal_ear_physiology1.62719015
55MP0006072_abnormal_retinal_apoptosis1.61816240
56MP0002398_abnormal_bone_marrow1.61223220
57MP0002998_abnormal_bone_remodeling1.61177803
58MP0001545_abnormal_hematopoietic_system1.60792564
59MP0005397_hematopoietic_system_phenotyp1.60792564
60MP0005670_abnormal_white_adipose1.59868586
61MP0005394_taste/olfaction_phenotype1.59721681
62MP0005499_abnormal_olfactory_system1.59721681
63MP0002006_tumorigenesis1.55071663
64MP0004947_skin_inflammation1.54068750
65MP0003693_abnormal_embryo_hatching1.53643008
66MP0005167_abnormal_blood-brain_barrier1.53611143
67MP0008995_early_reproductive_senescence1.52203079
68MP0000858_altered_metastatic_potential1.51046310
69MP0002933_joint_inflammation1.50855623
70MP0004019_abnormal_vitamin_homeostasis1.43082556
71MP0001529_abnormal_vocalization1.42673797
72MP0008469_abnormal_protein_level1.41860184
73MP0005164_abnormal_response_to1.41791536
74MP0004133_heterotaxia1.40885301
75MP0005253_abnormal_eye_physiology1.40593397
76MP0000689_abnormal_spleen_morphology1.39419752
77MP0001299_abnormal_eye_distance/1.38161574
78MP0002722_abnormal_immune_system1.37375707
79MP0009278_abnormal_bone_marrow1.36711332
80MP0002429_abnormal_blood_cell1.36006254
81MP0004272_abnormal_basement_membrane1.34691083
82MP0001879_abnormal_lymphatic_vessel1.34229813
83MP0002653_abnormal_ependyma_morphology1.31691314
84MP0003075_altered_response_to1.30360513
85MP0003937_abnormal_limbs/digits/tail_de1.29168128
86MP0010352_gastrointestinal_tract_polyps1.28763716
87MP0002638_abnormal_pupillary_reflex1.28522482
88MP0000372_irregular_coat_pigmentation1.27589524
89MP0002166_altered_tumor_susceptibility1.27061834
90MP0003186_abnormal_redox_activity1.26509066
91MP0005390_skeleton_phenotype1.26120251
92MP0002735_abnormal_chemical_nociception1.25702919
93MP0005166_decreased_susceptibility_to1.25692261
94MP0005058_abnormal_lysosome_morphology1.25293244
95MP0003315_abnormal_perineum_morphology1.25255297
96MP0000647_abnormal_sebaceous_gland1.22601201
97MP0003763_abnormal_thymus_physiology1.22336540
98MP0002751_abnormal_autonomic_nervous1.20874026
99MP0003122_maternal_imprinting1.20590598
100MP0003191_abnormal_cellular_cholesterol1.19294274
101MP0005666_abnormal_adipose_tissue1.19023695
102MP0001485_abnormal_pinna_reflex1.17869712
103MP0000631_abnormal_neuroendocrine_gland1.16969172
104MP0000249_abnormal_blood_vessel1.16530735
105MP0008932_abnormal_embryonic_tissue1.16265044
106MP0005174_abnormal_tail_pigmentation1.16237600
107MP0002132_abnormal_respiratory_system1.14746037
108MP0008438_abnormal_cutaneous_collagen1.14444828
109MP0005551_abnormal_eye_electrophysiolog1.14242650
110MP0000383_abnormal_hair_follicle1.13576926
111MP0002233_abnormal_nose_morphology1.13254753
112MP0004883_abnormal_blood_vessel1.11250977
113MP0003755_abnormal_palate_morphology1.10857955
114MP0003567_abnormal_fetal_cardiomyocyte1.09710263
115MP0002282_abnormal_trachea_morphology1.09152071
116MP0010094_abnormal_chromosome_stability1.08589326
117MP0004957_abnormal_blastocyst_morpholog1.07905715
118MP0002234_abnormal_pharynx_morphology1.07196875
119MP0001968_abnormal_touch/_nociception1.05899613
120MP0001286_abnormal_eye_development1.05665690
121MP0002697_abnormal_eye_size1.04362196
122MP0000490_abnormal_crypts_of1.03319082
123MP0000778_abnormal_nervous_system1.03247559
124MP0005076_abnormal_cell_differentiation1.02959031
125MP0003718_maternal_effect1.02724070
126MP0001984_abnormal_olfaction1.02578696
127MP0002277_abnormal_respiratory_mucosa1.02178534
128MP0004885_abnormal_endolymph1.01804710
129MP0004808_abnormal_hematopoietic_stem1.01713590
130MP0004142_abnormal_muscle_tone1.00931073
131MP0001881_abnormal_mammary_gland1.00490708
132MP0005391_vision/eye_phenotype0.98805589
133MP0000026_abnormal_inner_ear0.98711573
134MP0001851_eye_inflammation0.97205580
135MP0000579_abnormal_nail_morphology0.97020772
136MP0008007_abnormal_cellular_replicative0.94170134
137MP0008872_abnormal_physiological_respon0.94128290
138MP0001502_abnormal_circadian_rhythm0.92112536
139MP0003890_abnormal_embryonic-extraembry0.92032667
140MP0005275_abnormal_skin_tensile0.91887033
141MP0001177_atelectasis0.91103307
142MP0008877_abnormal_DNA_methylation0.90883797
143MP0009046_muscle_twitch0.90363183
144MP0002557_abnormal_social/conspecific_i0.90202283
145MP0003786_premature_aging0.90025170
146MP0005645_abnormal_hypothalamus_physiol0.89952762
147MP0000762_abnormal_tongue_morphology0.89515220
148MP0003795_abnormal_bone_structure0.89377911
149MP0003077_abnormal_cell_cycle0.87407151
150MP0000703_abnormal_thymus_morphology0.87192495
151MP0009745_abnormal_behavioral_response0.86655003
152MP0001542_abnormal_bone_strength0.86288424
153MP0002160_abnormal_reproductive_system0.86187291
154MP0002396_abnormal_hematopoietic_system0.85578262
155MP0003942_abnormal_urinary_system0.84590761
156MP0010368_abnormal_lymphatic_system0.83997721
157MP0002909_abnormal_adrenal_gland0.82738261
158MP0003453_abnormal_keratinocyte_physiol0.82480919
159MP0003866_abnormal_defecation0.82158533
160MP0001324_abnormal_eye_pigmentation0.81464559
161MP0005187_abnormal_penis_morphology0.80295569
162MP0005310_abnormal_salivary_gland0.78691992
163MP0001873_stomach_inflammation0.78202129
164MP0004742_abnormal_vestibular_system0.77950004
165MP0005023_abnormal_wound_healing0.77560939
166MP0003121_genomic_imprinting0.77195720
167MP0006276_abnormal_autonomic_nervous0.73992262
168MP0002822_catalepsy0.73788328
169MP0001486_abnormal_startle_reflex0.73636455
170MP0003111_abnormal_nucleus_morphology0.73600465
171MP0009763_increased_sensitivity_to0.73384677
172MP0003941_abnormal_skin_development0.73097785
173MP0000653_abnormal_sex_gland0.73062930
174MP0002210_abnormal_sex_determination0.72801662
175MP0002111_abnormal_tail_morphology0.72724620
176MP0002272_abnormal_nervous_system0.72069414
177MP0003221_abnormal_cardiomyocyte_apopto0.71378283
178MP0001663_abnormal_digestive_system0.70916734
179MP0002877_abnormal_melanocyte_morpholog0.70831240
180MP0006036_abnormal_mitochondrial_physio0.69222457
181MP0003936_abnormal_reproductive_system0.68959501
182MP0003566_abnormal_cell_adhesion0.68144993
183MP0009840_abnormal_foam_cell0.67065645
184MP0002295_abnormal_pulmonary_circulatio0.65906602
185MP0002019_abnormal_tumor_incidence0.64594434
186MP0003300_gastrointestinal_ulcer0.63711561
187MP0002168_other_aberrant_phenotype0.63217272
188MP0002136_abnormal_kidney_physiology0.62265054
189MP0005165_increased_susceptibility_to0.62009094
190MP0005408_hypopigmentation0.61199233
191MP0000627_abnormal_mammary_gland0.59248195
192MP0008873_increased_physiological_sensi0.54729453
193MP0000604_amyloidosis0.53777386
194MP0003279_aneurysm0.52288454
195MP0001727_abnormal_embryo_implantation0.50620803
196MP0000767_abnormal_smooth_muscle0.50200616

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.44815408
2Recurrent abscess formation (HP:0002722)6.36311227
3Recurrent bacterial skin infections (HP:0005406)5.55961481
4Retrobulbar optic neuritis (HP:0100654)5.25650784
5Optic neuritis (HP:0100653)5.25650784
6Orchitis (HP:0100796)5.09320815
7Recurrent gram-negative bacterial infections (HP:0005420)5.01476983
8Myositis (HP:0100614)4.99717777
9Mediastinal lymphadenopathy (HP:0100721)4.95133373
10Abnormality of macrophages (HP:0004311)4.44614900
11Stomatitis (HP:0010280)4.28283014
12Acute necrotizing encephalopathy (HP:0006965)4.03251914
13Obstructive lung disease (HP:0006536)3.85397682
14Chronic obstructive pulmonary disease (HP:0006510)3.85397682
15Elevated erythrocyte sedimentation rate (HP:0003565)3.80573694
16Abnormality of glycolysis (HP:0004366)3.68322172
17Increased serum pyruvate (HP:0003542)3.65044928
18Abnormal mitochondria in muscle tissue (HP:0008316)3.62485088
19Acute encephalopathy (HP:0006846)3.52389955
20Pustule (HP:0200039)3.47789546
21Mitochondrial inheritance (HP:0001427)3.46434275
22Recurrent skin infections (HP:0001581)3.36167453
23Recurrent fungal infections (HP:0002841)3.35192701
24Progressive macrocephaly (HP:0004481)3.29474714
25Axonal loss (HP:0003447)3.28430995
26Pulmonary infiltrates (HP:0002113)3.28300440
27Interstitial pulmonary disease (HP:0006530)3.26126753
28Gingivitis (HP:0000230)3.25255838
29Mutism (HP:0002300)3.17010599
30Septo-optic dysplasia (HP:0100842)3.15901398
31Keratoconjunctivitis sicca (HP:0001097)3.15316556
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.13170752
33Vacuolated lymphocytes (HP:0001922)3.12424339
34Increased CSF lactate (HP:0002490)3.08301393
35Agnosia (HP:0010524)3.07877325
36IgM deficiency (HP:0002850)3.07319239
37Increased hepatocellular lipid droplets (HP:0006565)3.05398844
38Hepatocellular necrosis (HP:0001404)3.04663766
39Vasculitis (HP:0002633)3.03395746
40Pancreatic cysts (HP:0001737)2.95220703
41Meningitis (HP:0001287)2.91575673
42Hepatic necrosis (HP:0002605)2.88744280
43Abnormality of the labia minora (HP:0012880)2.82676307
44Keratoconjunctivitis (HP:0001096)2.82433250
45Disinhibition (HP:0000734)2.81238030
46Pancreatic fibrosis (HP:0100732)2.79981651
47Arterial thrombosis (HP:0004420)2.79671370
48Lipid accumulation in hepatocytes (HP:0006561)2.72121377
49Prostate neoplasm (HP:0100787)2.71791769
50True hermaphroditism (HP:0010459)2.71039363
51Cellulitis (HP:0100658)2.70843561
52Hemoptysis (HP:0002105)2.69977426
53Concave nail (HP:0001598)2.65868686
54Recurrent pneumonia (HP:0006532)2.65767683
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.63410352
56Abnormality of cells of the erythroid lineage (HP:0012130)2.62343873
57Cerebral edema (HP:0002181)2.55273977
58Petechiae (HP:0000967)2.54622344
59Leukocytosis (HP:0001974)2.54370110
60Recurrent viral infections (HP:0004429)2.52315428
61Hyperglycinemia (HP:0002154)2.51483941
62Abnormal number of erythroid precursors (HP:0012131)2.50486688
63Spontaneous hematomas (HP:0007420)2.50479256
64Renal Fanconi syndrome (HP:0001994)2.48069278
65Reduced antithrombin III activity (HP:0001976)2.45125018
66Glomerulopathy (HP:0100820)2.44027217
67Colon cancer (HP:0003003)2.37586917
68Poor head control (HP:0002421)2.35206124
69Macrocytic anemia (HP:0001972)2.34670533
70Osteomyelitis (HP:0002754)2.32814100
71Increased cerebral lipofuscin (HP:0011813)2.32766521
72Absent septum pellucidum (HP:0001331)2.30130109
73Anorexia (HP:0002039)2.29504791
74Bifid tongue (HP:0010297)2.28252066
75Medial flaring of the eyebrow (HP:0010747)2.27451150
76Autoimmune thrombocytopenia (HP:0001973)2.27165327
77Abnormality of midbrain morphology (HP:0002418)2.26006642
78Molar tooth sign on MRI (HP:0002419)2.26006642
793-Methylglutaconic aciduria (HP:0003535)2.23471912
80Increased serum lactate (HP:0002151)2.23347259
81Abnormality of the prostate (HP:0008775)2.22978276
82Abnormality of the lumbar spine (HP:0100712)2.22044276
83Thrombocytosis (HP:0001894)2.21948333
84Urticaria (HP:0001025)2.21586263
85Recurrent cutaneous fungal infections (HP:0011370)2.20903128
86Chronic mucocutaneous candidiasis (HP:0002728)2.20903128
87Periodontitis (HP:0000704)2.20718320
88Aplasia/Hypoplasia of the tongue (HP:0010295)2.20704912
89Stenosis of the external auditory canal (HP:0000402)2.19283665
90Thyroiditis (HP:0100646)2.17928211
91Reticulocytopenia (HP:0001896)2.17603084
92Systemic lupus erythematosus (HP:0002725)2.15122125
93Abnormality of T cell number (HP:0011839)2.14561312
94Exercise intolerance (HP:0003546)2.14348239
95Recurrent lower respiratory tract infections (HP:0002783)2.14241255
96Prolonged bleeding time (HP:0003010)2.14071769
97Gangrene (HP:0100758)2.13870716
98Pulmonary embolism (HP:0002204)2.12664132
99Basal ganglia calcification (HP:0002135)2.11256977
100Nephronophthisis (HP:0000090)2.11165733
101Epistaxis (HP:0000421)2.10740314
102Hypoplastic pelvis (HP:0008839)2.10623897
103Meckel diverticulum (HP:0002245)2.09537381
104Abnormality of T cells (HP:0002843)2.09457539
105T lymphocytopenia (HP:0005403)2.08986418
106Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08970373
107Abnormality of the pericardium (HP:0001697)2.05948417
108Vaginal atresia (HP:0000148)2.04383650
109Supernumerary spleens (HP:0009799)2.04253620
110Thick nail (HP:0001805)2.04072528
111Abnormality of T cell physiology (HP:0011840)2.03636975
112Severe combined immunodeficiency (HP:0004430)2.01734761
113Lymphopenia (HP:0001888)2.01563352
114Genital tract atresia (HP:0001827)2.01112511
115Optic nerve hypoplasia (HP:0000609)2.00322144
116Arthralgia (HP:0002829)2.00293498
117IgG deficiency (HP:0004315)1.99000623
118Abnormality of the ileum (HP:0001549)1.97913040
119Aplasia/Hypoplasia of the uvula (HP:0010293)1.96891800
120Impaired proprioception (HP:0010831)1.96782731
121Oral leukoplakia (HP:0002745)1.96433140
122Methylmalonic acidemia (HP:0002912)1.96181500
123Gait imbalance (HP:0002141)1.94569920
124Congenital primary aphakia (HP:0007707)1.94486666
125Type I transferrin isoform profile (HP:0003642)1.94391318
126Anencephaly (HP:0002323)1.94292982
127Sepsis (HP:0100806)1.93672013
128Abnormality of the phalanges of the 2nd finger (HP:0009541)1.93602588
129Anophthalmia (HP:0000528)1.93598912
130Optic disc pallor (HP:0000543)1.92525406
131Abnormality of eosinophils (HP:0001879)1.91631654
132Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91621811
133Abnormality of cells of the lymphoid lineage (HP:0012140)1.91577841
134Combined immunodeficiency (HP:0005387)1.91480303
135Sclerocornea (HP:0000647)1.91434132
136Abnormal gallbladder physiology (HP:0012438)1.89270040
137Cholecystitis (HP:0001082)1.89270040
138Pendular nystagmus (HP:0012043)1.89181171
139Maternal diabetes (HP:0009800)1.88965985
140Beaking of vertebral bodies (HP:0004568)1.88763553
141J-shaped sella turcica (HP:0002680)1.87479200
142Small hand (HP:0200055)1.87216110
143Lactic acidosis (HP:0003128)1.87207659
144Abnormality of the septum pellucidum (HP:0007375)1.86911027
145Methylmalonic aciduria (HP:0012120)1.86875221
146Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85900922
147Renal duplication (HP:0000075)1.84787187
148Abnormality of the pleura (HP:0002103)1.84624488
149Hepatosplenomegaly (HP:0001433)1.84325062
150Albinism (HP:0001022)1.84086060
151Abnormality of the renal medulla (HP:0100957)1.83492637
152Thoracic kyphosis (HP:0002942)1.81510134
153Encephalitis (HP:0002383)1.81343911
154Nephrogenic diabetes insipidus (HP:0009806)1.81305379
155Triphalangeal thumb (HP:0001199)1.81041251
156Persistence of primary teeth (HP:0006335)1.80193075
157Abnormality of the pons (HP:0007361)1.79957555
158Respiratory failure (HP:0002878)1.79348575
159Joint swelling (HP:0001386)1.77943380
160Increased intramyocellular lipid droplets (HP:0012240)1.76722833
161Recurrent bronchitis (HP:0002837)1.76099339
162Hypoplastic female external genitalia (HP:0012815)1.76043777
163Exertional dyspnea (HP:0002875)1.75807747
164Epiphyseal dysplasia (HP:0002656)1.75759202
165Oligodactyly (hands) (HP:0001180)1.75488890
166Birth length less than 3rd percentile (HP:0003561)1.74625612
167Chronic otitis media (HP:0000389)1.74560531
168Abnormality of alanine metabolism (HP:0010916)1.73927871
169Hyperalaninemia (HP:0003348)1.73927871
170Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73927871
171Partial duplication of the phalanx of hand (HP:0009999)1.72918788
172Chromsome breakage (HP:0040012)1.72813998
173Abnormality of serum amino acid levels (HP:0003112)1.72611002
174Osteolytic defects of the hand bones (HP:0009699)1.72389639
175Osteolytic defects of the phalanges of the hand (HP:0009771)1.72389639
176Horseshoe kidney (HP:0000085)1.72362605
177Labial hypoplasia (HP:0000066)1.72362144
178Purpura (HP:0000979)1.72089179
179Abnormality of serine family amino acid metabolism (HP:0010894)1.71844799
180Abnormality of glycine metabolism (HP:0010895)1.71844799
181Eosinophilia (HP:0001880)1.71194816
182Skin ulcer (HP:0200042)1.70947225
183Vertebral compression fractures (HP:0002953)1.70667951
184Synostosis involving the elbow (HP:0003938)1.68069973
185Humeroradial synostosis (HP:0003041)1.68069973
186Hypoplasia of the pons (HP:0012110)1.67392129
187Cystic liver disease (HP:0006706)1.66446581
188Delayed CNS myelination (HP:0002188)1.64773554
189Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.63375694
190Hemivertebrae (HP:0002937)1.63218237
191Short tibia (HP:0005736)1.62544298
192Bilateral microphthalmos (HP:0007633)1.61958649
193Leukodystrophy (HP:0002415)1.60342951
194Abnormality of renal resorption (HP:0011038)1.59890616
195Lethargy (HP:0001254)1.59450462
196Congenital, generalized hypertrichosis (HP:0004540)1.58710116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIM24.26577007
2MAP3K144.03626698
3VRK23.86211885
4IRAK33.45329200
5MAP4K23.22149583
6PBK3.16334191
7TXK3.06487427
8MAP4K12.96940386
9ZAK2.91584614
10ARAF2.90041045
11MAP3K102.57422613
12VRK12.54857088
13BCKDK2.50640607
14BLK2.48339434
15TBK12.47982637
16IRAK42.44849332
17EPHB22.30338348
18IKBKB2.22665888
19STK162.22228011
20NME22.12613015
21WNK32.10192415
22TNIK2.04125801
23IKBKE2.03272553
24DYRK22.03236044
25BMPR1B1.98141667
26NME11.93663557
27MAP3K31.88930649
28BTK1.85579494
29CDC71.82523170
30STK241.78971234
31JAK31.78048943
32NEK11.75881823
33PIM11.71554049
34MST41.70775442
35SRPK11.68798896
36DDR21.68583902
37PKN21.67141914
38KDR1.66611275
39TEC1.63148877
40TTK1.58889328
41KIT1.56183943
42STK391.53916999
43PLK31.53522929
44MAP3K111.51500457
45ABL21.51064944
46ZAP701.45142248
47TRIM281.43861517
48WNK41.43645619
49MAP2K31.39362398
50TLK11.38751067
51CASK1.33325902
52SYK1.28720383
53NEK91.27756097
54TGFBR21.23172569
55EPHB11.22413542
56ADRBK21.22302530
57NUAK11.21158464
58MAP3K91.19433922
59PDK21.14600443
60CSF1R1.14105963
61CHUK1.13515106
62EIF2AK11.12632103
63TYK21.12541613
64RIPK11.10996804
65BRSK11.10444379
66MAP3K41.08124852
67BMPR21.07233847
68MAP3K121.04604151
69INSRR1.03910236
70HCK1.03492192
71MKNK11.03202671
72FGFR11.02429395
73LYN1.01790599
74EIF2AK21.01546897
75PLK11.01510642
76RIPK41.00145215
77TAOK20.99560971
78MAP2K70.96937218
79RAF10.96843121
80TAF10.96076715
81EIF2AK30.95874822
82ITK0.93608739
83STK100.92994224
84TIE10.92918255
85TAOK30.92715600
86MUSK0.92114531
87BRSK20.91410088
88TGFBR10.91272855
89MARK10.90469873
90PLK20.90234527
91NEK20.86797152
92CDK80.85934969
93PINK10.85494664
94LCK0.85102611
95PAK40.84416049
96LATS20.83838096
97EPHA40.83275370
98JAK10.83233957
99RPS6KA40.82775636
100BMX0.81664554
101MKNK20.76104402
102FES0.75856072
103BCR0.74397489
104ABL10.73005716
105MAPKAPK50.72882089
106ATR0.70041913
107CSNK1G20.69938044
108PRKCG0.69426373
109MAPK150.69304898
110CSK0.66803952
111MAP3K130.66733695
112ACVR1B0.66268100
113GRK70.65539729
114FGFR20.65512265
115NLK0.64587055
116AURKA0.62348627
117ADRBK10.61295720
118NEK60.61051910
119MARK30.60568814
120CHEK20.60250039
121AURKB0.60235955
122CSNK1G30.60099237
123CSNK1G10.60010139
124RPS6KA60.59974865
125LRRK20.58915690
126PRKCE0.58154955
127MAPK40.57875676
128PRKG20.57851984
129CSNK1A1L0.57831564
130CSNK2A10.57011780
131ERBB30.56401159
132NTRK20.56061315
133CCNB10.55928162
134MAPK130.55632113
135RPS6KC10.53885159
136RPS6KL10.53885159
137DYRK30.53662637
138MOS0.53363592
139FRK0.51970798
140EPHA30.51023677
141CAMKK20.50891843
142CSNK2A20.50831988
143TAOK10.50794256
144MAPKAPK20.49490875
145CDK30.48935534
146PKN10.47907827
147WEE10.47728397
148MAP2K60.47468163
149RPS6KA50.46955322
150DYRK1A0.46749529
151EPHA20.46525461
152JAK20.45074077
153PNCK0.44613962
154PRKCD0.44203820
155PLK40.43065175
156CSNK1A10.42979757
157IRAK10.42680875
158CSNK1E0.42660303
159ATM0.42132412
160ERN10.41373182
161STK40.40822272
162SIK30.40777962
163BUB10.40633994
164STK38L0.40275892
165ILK0.39882716
166MATK0.38765649
167BRAF0.38654719
168FGFR30.38554080
169MYLK0.38171197
170ERBB40.38051799
171MAPK70.36932960
172RPS6KA10.36387677
173CAMK10.34943371
174MST1R0.34884383
175GSK3A0.34508279
176FLT30.34302031
177BRD40.33678327
178TSSK60.33163495
179GRK10.33051857
180MAPK120.32878221
181CHEK10.32038654
182PRKACB0.31903128

Predicted pathways (KEGG)

RankGene SetZ-score
1Parkinsons disease_Homo sapiens_hsa050123.31963889
2Leishmaniasis_Homo sapiens_hsa051403.12825243
3Graft-versus-host disease_Homo sapiens_hsa053322.94473446
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.70287840
5Legionellosis_Homo sapiens_hsa051342.66448760
6Rheumatoid arthritis_Homo sapiens_hsa053232.62857331
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.62659329
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.62419696
9Mismatch repair_Homo sapiens_hsa034302.61004092
10Huntingtons disease_Homo sapiens_hsa050162.45998414
11Homologous recombination_Homo sapiens_hsa034402.30560017
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.28340776
13Osteoclast differentiation_Homo sapiens_hsa043802.23152394
14Ribosome_Homo sapiens_hsa030102.17340222
15Alzheimers disease_Homo sapiens_hsa050102.11353519
16Toll-like receptor signaling pathway_Homo sapiens_hsa046202.11334955
17Malaria_Homo sapiens_hsa051442.07202006
18Staphylococcus aureus infection_Homo sapiens_hsa051502.07006065
19NOD-like receptor signaling pathway_Homo sapiens_hsa046212.06753800
20Pertussis_Homo sapiens_hsa051332.04951790
21Asthma_Homo sapiens_hsa053102.04434658
22Tuberculosis_Homo sapiens_hsa051521.99398843
23Proteasome_Homo sapiens_hsa030501.95060557
24Allograft rejection_Homo sapiens_hsa053301.93644443
25Propanoate metabolism_Homo sapiens_hsa006401.93427093
26Phagosome_Homo sapiens_hsa041451.89479101
27Salmonella infection_Homo sapiens_hsa051321.89385072
28Hematopoietic cell lineage_Homo sapiens_hsa046401.87775778
29Measles_Homo sapiens_hsa051621.86529045
30Fanconi anemia pathway_Homo sapiens_hsa034601.78451549
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77249756
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.72267543
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.70666327
34TNF signaling pathway_Homo sapiens_hsa046681.66448367
35One carbon pool by folate_Homo sapiens_hsa006701.60547270
36Nitrogen metabolism_Homo sapiens_hsa009101.60333622
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.56213087
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.55896491
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47487270
40Shigellosis_Homo sapiens_hsa051311.46363476
41Fructose and mannose metabolism_Homo sapiens_hsa000511.44759427
42Pyruvate metabolism_Homo sapiens_hsa006201.44644463
43Cardiac muscle contraction_Homo sapiens_hsa042601.44059103
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41043056
45Antigen processing and presentation_Homo sapiens_hsa046121.40079731
46Nucleotide excision repair_Homo sapiens_hsa034201.39745200
47Herpes simplex infection_Homo sapiens_hsa051681.37575308
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37466398
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36554698
50Type I diabetes mellitus_Homo sapiens_hsa049401.36282586
51Influenza A_Homo sapiens_hsa051641.36033614
52Mineral absorption_Homo sapiens_hsa049781.35747972
53Lysosome_Homo sapiens_hsa041421.34405668
54Apoptosis_Homo sapiens_hsa042101.34380595
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33460207
56Steroid biosynthesis_Homo sapiens_hsa001001.32161322
57Primary immunodeficiency_Homo sapiens_hsa053401.28316710
58Toxoplasmosis_Homo sapiens_hsa051451.25266188
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23158353
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.22121382
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21904530
62Non-homologous end-joining_Homo sapiens_hsa034501.21316782
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20960375
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17085467
65Fatty acid elongation_Homo sapiens_hsa000621.16786495
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16728562
67Glutathione metabolism_Homo sapiens_hsa004801.15272833
68Protein export_Homo sapiens_hsa030601.14712946
69Butanoate metabolism_Homo sapiens_hsa006501.14652925
70B cell receptor signaling pathway_Homo sapiens_hsa046621.12906670
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12128724
72Biosynthesis of amino acids_Homo sapiens_hsa012301.07644142
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03066249
74Purine metabolism_Homo sapiens_hsa002301.01389698
75RNA transport_Homo sapiens_hsa030131.00491305
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97991251
77Arginine and proline metabolism_Homo sapiens_hsa003300.97708132
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.97378799
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.96250067
80Hepatitis B_Homo sapiens_hsa051610.94617906
81Collecting duct acid secretion_Homo sapiens_hsa049660.93817337
82Epstein-Barr virus infection_Homo sapiens_hsa051690.93606559
83Chemokine signaling pathway_Homo sapiens_hsa040620.92896180
84Vibrio cholerae infection_Homo sapiens_hsa051100.92510692
85T cell receptor signaling pathway_Homo sapiens_hsa046600.92016675
86African trypanosomiasis_Homo sapiens_hsa051430.89898381
87Carbon metabolism_Homo sapiens_hsa012000.89393900
88Sulfur relay system_Homo sapiens_hsa041220.89351405
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.88585457
90Tryptophan metabolism_Homo sapiens_hsa003800.87378580
91Selenocompound metabolism_Homo sapiens_hsa004500.87199019
92Metabolic pathways_Homo sapiens_hsa011000.81206617
93Acute myeloid leukemia_Homo sapiens_hsa052210.79727474
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77702048
95RNA polymerase_Homo sapiens_hsa030200.77436585
96Autoimmune thyroid disease_Homo sapiens_hsa053200.75587976
97Basal cell carcinoma_Homo sapiens_hsa052170.75009341
98Linoleic acid metabolism_Homo sapiens_hsa005910.74992334
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74989476
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74515496
101Phototransduction_Homo sapiens_hsa047440.74216362
102Viral myocarditis_Homo sapiens_hsa054160.73687490
103Amoebiasis_Homo sapiens_hsa051460.72632323
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71877041
105Platelet activation_Homo sapiens_hsa046110.70975507
106Nicotine addiction_Homo sapiens_hsa050330.70907921
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70798033
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70283087
109Other glycan degradation_Homo sapiens_hsa005110.69490650
110Cell cycle_Homo sapiens_hsa041100.68947194
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68598227
112Folate biosynthesis_Homo sapiens_hsa007900.67579840
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67095114
114p53 signaling pathway_Homo sapiens_hsa041150.65957331
115Hedgehog signaling pathway_Homo sapiens_hsa043400.65228798
116beta-Alanine metabolism_Homo sapiens_hsa004100.64782636
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64587742
118Chemical carcinogenesis_Homo sapiens_hsa052040.64566289
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64446430
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64419504
121Phenylalanine metabolism_Homo sapiens_hsa003600.64153461
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62236516
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61745746
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61290377
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60054262
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.59364640
127HIF-1 signaling pathway_Homo sapiens_hsa040660.58447360
128Peroxisome_Homo sapiens_hsa041460.58024674
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.57938047
130Basal transcription factors_Homo sapiens_hsa030220.57933697
131Pyrimidine metabolism_Homo sapiens_hsa002400.57170096
132Oxidative phosphorylation_Homo sapiens_hsa001900.56270906
133DNA replication_Homo sapiens_hsa030300.55997099
134Hepatitis C_Homo sapiens_hsa051600.55589379
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55538980
136Viral carcinogenesis_Homo sapiens_hsa052030.55407214
137Fatty acid metabolism_Homo sapiens_hsa012120.54938865
138Vitamin digestion and absorption_Homo sapiens_hsa049770.53318575
139Complement and coagulation cascades_Homo sapiens_hsa046100.53271698
140Galactose metabolism_Homo sapiens_hsa000520.52988510
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52002725
142Small cell lung cancer_Homo sapiens_hsa052220.50957623
143HTLV-I infection_Homo sapiens_hsa051660.50844425
144Ether lipid metabolism_Homo sapiens_hsa005650.47925651
145PPAR signaling pathway_Homo sapiens_hsa033200.47573859
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46926022
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44668866
148Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44265060
149Tyrosine metabolism_Homo sapiens_hsa003500.43409881
150Starch and sucrose metabolism_Homo sapiens_hsa005000.43374716
151Vitamin B6 metabolism_Homo sapiens_hsa007500.43005374
152Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41120801
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40335207
154Circadian rhythm_Homo sapiens_hsa047100.40020421
155Prion diseases_Homo sapiens_hsa050200.37715506
156Pentose phosphate pathway_Homo sapiens_hsa000300.36567534
157Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36514868
158Spliceosome_Homo sapiens_hsa030400.36182702
159Sulfur metabolism_Homo sapiens_hsa009200.35975447
160Retinol metabolism_Homo sapiens_hsa008300.35942021
161Fatty acid degradation_Homo sapiens_hsa000710.35471842
162Base excision repair_Homo sapiens_hsa034100.35221893
163Arachidonic acid metabolism_Homo sapiens_hsa005900.34790552
164Chronic myeloid leukemia_Homo sapiens_hsa052200.33227128
165Sphingolipid metabolism_Homo sapiens_hsa006000.32430220
166FoxO signaling pathway_Homo sapiens_hsa040680.32208321
167Fat digestion and absorption_Homo sapiens_hsa049750.31919319
168Pancreatic cancer_Homo sapiens_hsa052120.31220681
169Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30891956
170Fatty acid biosynthesis_Homo sapiens_hsa000610.30822708
171Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30168935
172RNA degradation_Homo sapiens_hsa030180.28952738
173Primary bile acid biosynthesis_Homo sapiens_hsa001200.24988525
174Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24856828
175Proteoglycans in cancer_Homo sapiens_hsa052050.24737755
176Thyroid cancer_Homo sapiens_hsa052160.22937765
177Neurotrophin signaling pathway_Homo sapiens_hsa047220.21043553
178Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20921293

Most similar genes based on co-expression Upload to Enrichr

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