HIGD2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)7.96795917
2piRNA metabolic process (GO:0034587)7.67613124
3cell wall macromolecule catabolic process (GO:0016998)5.84206144
4sulfation (GO:0051923)5.65380239
5male meiosis I (GO:0007141)5.48976752
6DNA methylation involved in gamete generation (GO:0043046)5.46774293
7chromosome organization involved in meiosis (GO:0070192)5.29154002
8meiotic chromosome segregation (GO:0045132)5.20064827
9kidney mesenchyme development (GO:0072074)5.13373982
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.11339742
11mitochondrial respiratory chain complex I assembly (GO:0032981)5.11339742
12NADH dehydrogenase complex assembly (GO:0010257)5.11339742
13male meiosis (GO:0007140)5.01522829
14regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)4.95009753
15Notch signaling involved in heart development (GO:0061314)4.94505576
16positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)4.82317147
17cell wall macromolecule metabolic process (GO:0044036)4.74059698
18resolution of meiotic recombination intermediates (GO:0000712)4.60828656
19negative regulation of smooth muscle cell differentiation (GO:0051151)4.57337110
20metanephric mesenchyme development (GO:0072075)4.56006649
21oogenesis (GO:0048477)4.50222233
22negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.27727000
23female gamete generation (GO:0007292)4.11976414
24positive regulation of DNA-templated transcription, initiation (GO:2000144)4.08395643
25ribosomal small subunit biogenesis (GO:0042274)4.07272865
26regulation of DNA-templated transcription, initiation (GO:2000142)4.05968856
27synaptonemal complex assembly (GO:0007130)4.04702681
28negative regulation of Rho protein signal transduction (GO:0035024)4.03814774
29regulation of meiosis I (GO:0060631)4.01810419
30synaptonemal complex organization (GO:0070193)4.00456282
31somite development (GO:0061053)3.99246691
32maturation of SSU-rRNA (GO:0030490)3.98832648
33epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.98241489
34meiosis I (GO:0007127)3.94804910
35embryonic body morphogenesis (GO:0010172)3.92878367
36coronary vasculature morphogenesis (GO:0060977)3.90044863
37mesenchymal cell development (GO:0014031)3.89641314
38renal absorption (GO:0070293)3.88177541
39meiotic nuclear division (GO:0007126)3.81899715
40regulation of cardiac muscle cell apoptotic process (GO:0010665)3.81193873
41mitochondrial DNA replication (GO:0006264)3.72298999
42negative regulation of transcription regulatory region DNA binding (GO:2000678)3.71596381
43positive regulation of catenin import into nucleus (GO:0035413)3.62042319
44protein complex biogenesis (GO:0070271)3.61111002
45motile cilium assembly (GO:0044458)3.60997629
46pattern specification involved in kidney development (GO:0061004)3.59180105
47spindle assembly involved in mitosis (GO:0090307)3.54784153
48regulation of striated muscle cell apoptotic process (GO:0010662)3.52795288
49heart valve formation (GO:0003188)3.52760221
50ventricular cardiac muscle cell development (GO:0055015)3.52522062
51aorta morphogenesis (GO:0035909)3.51594898
52cochlea development (GO:0090102)3.49768518
53negative regulation of homotypic cell-cell adhesion (GO:0034111)3.48354508
54negative regulation of striated muscle cell apoptotic process (GO:0010664)3.42535934
55meiotic cell cycle process (GO:1903046)3.39583503
56gamma-aminobutyric acid transport (GO:0015812)3.35711867
57ventricular trabecula myocardium morphogenesis (GO:0003222)3.26984207
58positive regulation of meiosis (GO:0045836)3.26262880
59regulation of centrosome cycle (GO:0046605)3.26034427
60proteasome assembly (GO:0043248)3.22464361
61regulation of cilium movement (GO:0003352)3.20898184
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.16967312
63stem cell development (GO:0048864)3.15163834
64regulation of centrosome duplication (GO:0010824)3.15103768
65negative regulation of meiosis (GO:0045835)3.13949984
66regulation of telomerase activity (GO:0051972)3.13154450
67mitochondrial respiratory chain complex assembly (GO:0033108)3.12933327
68regulation of vasculogenesis (GO:2001212)3.10972536
69negative regulation of telomerase activity (GO:0051974)3.07494630
70regulation of secondary heart field cardioblast proliferation (GO:0003266)3.05505589
71regulation of cardioblast proliferation (GO:0003264)3.05505589
72replicative senescence (GO:0090399)3.02059666
73positive regulation of meiotic cell cycle (GO:0051446)2.99718262
74DNA replication checkpoint (GO:0000076)2.94310422
75dermatan sulfate biosynthetic process (GO:0030208)2.93910750
76ventricular septum morphogenesis (GO:0060412)2.93625437
77mucosal immune response (GO:0002385)2.90349108
78DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.89742700
79regulation of germinal center formation (GO:0002634)2.89615706
80organ or tissue specific immune response (GO:0002251)2.89394853
81viral protein processing (GO:0019082)2.89388735
82nephron tubule morphogenesis (GO:0072078)2.88693193
83nephron epithelium morphogenesis (GO:0072088)2.88693193
84viral transcription (GO:0019083)2.87133207
85renal tubule morphogenesis (GO:0061333)2.84319685
86gonadal mesoderm development (GO:0007506)2.83269359
87positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.82308684
88cardiac epithelial to mesenchymal transition (GO:0060317)2.80876967
89germinal center formation (GO:0002467)2.80000166
90nephron tubule formation (GO:0072079)2.79621925
91fat-soluble vitamin biosynthetic process (GO:0042362)2.77768420
92cardiac left ventricle morphogenesis (GO:0003214)2.74422264
93meiotic cell cycle (GO:0051321)2.73911735
94regulation of DNA endoreduplication (GO:0032875)2.73861860
95regulation of meiosis (GO:0040020)2.73318349
96cardiac right ventricle morphogenesis (GO:0003215)2.72544583
97positive regulation of glomerulus development (GO:0090193)2.71990975
98translational termination (GO:0006415)2.71696609
99body morphogenesis (GO:0010171)2.71433130
100branching involved in labyrinthine layer morphogenesis (GO:0060670)2.70954698

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.39101565
2STAT6_21828071_ChIP-Seq_BEAS2B_Human5.22734609
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.05916212
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.58558405
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.48293197
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.45154461
7NOTCH1_21737748_ChIP-Seq_TLL_Human3.26078404
8RNF2_16625203_ChIP-ChIP_MESCs_Mouse3.16888277
9RNF2_27304074_Chip-Seq_NSC_Mouse2.67858659
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.64721022
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.59668063
12EWS_26573619_Chip-Seq_HEK293_Human2.46563135
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.42847594
14ZNF274_21170338_ChIP-Seq_K562_Hela2.39748697
15ELK1_19687146_ChIP-ChIP_HELA_Human2.31484657
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24818642
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20128312
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14688130
19LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09858255
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.04381298
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04327642
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.94047984
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92406940
24PKCTHETA_26484144_Chip-Seq_BREAST_Human1.92259165
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.89057275
26MYC_18940864_ChIP-ChIP_HL60_Human1.86273688
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80395468
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79481178
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.78842305
30TTF2_22483619_ChIP-Seq_HELA_Human1.77705247
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.74866629
32CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73593489
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71679270
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.70080508
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.64022631
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.64022631
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.64022631
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59262283
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58647279
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55971237
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52554080
42VDR_23849224_ChIP-Seq_CD4+_Human1.51811162
43KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.47505296
44ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44679768
45TDRD3_21172665_ChIP-Seq_MCF-7_Human1.44174332
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43780462
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41366245
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.38345180
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36900588
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35920903
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34315631
52TP53_20018659_ChIP-ChIP_R1E_Mouse1.33633541
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32824952
54FUS_26573619_Chip-Seq_HEK293_Human1.30481366
55XRN2_22483619_ChIP-Seq_HELA_Human1.30124895
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27952286
57STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.24394078
58HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22751005
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22651972
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19938409
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19518895
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.18897251
63VDR_22108803_ChIP-Seq_LS180_Human1.11315460
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.10998819
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10948055
66JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10135496
67TP53_16413492_ChIP-PET_HCT116_Human1.08833181
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.08761514
69ERG_20517297_ChIP-Seq_VCAP_Human1.07535532
70IGF1R_20145208_ChIP-Seq_DFB_Human1.07349931
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06383833
72AR_20517297_ChIP-Seq_VCAP_Human1.05200249
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04415613
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03820079
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03633208
76CIITA_25753668_ChIP-Seq_RAJI_Human1.03470579
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.02910039
78ERA_21632823_ChIP-Seq_H3396_Human1.01135534
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.00436308
80P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99742343
81FOXH1_21741376_ChIP-Seq_EPCs_Human0.99091788
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98920454
83NANOG_16153702_ChIP-ChIP_HESCs_Human0.98430847
84PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96422765
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94908494
86RUNX1_26923725_Chip-Seq_HPCs_Mouse0.94401858
87GABP_19822575_ChIP-Seq_HepG2_Human0.94053832
88SMAD4_21741376_ChIP-Seq_EPCs_Human0.92098626
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91096361
90MYC_18555785_ChIP-Seq_MESCs_Mouse0.90975874
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89696912
92P300_19829295_ChIP-Seq_ESCs_Human0.88722426
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88522844
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88337499
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87950624
96IRF1_19129219_ChIP-ChIP_H3396_Human0.86215754
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85805457
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.85805457
99RNF2_18974828_ChIP-Seq_MESCs_Mouse0.85727579
100EZH2_18974828_ChIP-Seq_MESCs_Mouse0.85727579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system3.90896465
2MP0009384_cardiac_valve_regurgitation3.24134373
3MP0002160_abnormal_reproductive_system3.03938466
4MP0003119_abnormal_digestive_system2.97876132
5MP0000678_abnormal_parathyroid_gland2.95934696
6MP0000537_abnormal_urethra_morphology2.93877436
7MP0000049_abnormal_middle_ear2.64985254
8MP0009053_abnormal_anal_canal2.63248401
9MP0001485_abnormal_pinna_reflex2.59985859
10MP0010368_abnormal_lymphatic_system2.39860126
11MP0008877_abnormal_DNA_methylation2.33115919
12MP0005389_reproductive_system_phenotype2.30355395
13MP0000516_abnormal_urinary_system2.27075219
14MP0005367_renal/urinary_system_phenotyp2.27075219
15MP0002139_abnormal_hepatobiliary_system2.25823044
16MP0003693_abnormal_embryo_hatching2.24040579
17MP0002210_abnormal_sex_determination2.16889247
18MP0002234_abnormal_pharynx_morphology2.10484671
19MP0001879_abnormal_lymphatic_vessel1.97161856
20MP0004510_myositis1.96117406
21MP0003937_abnormal_limbs/digits/tail_de1.93339675
22MP0005670_abnormal_white_adipose1.90948949
23MP0005174_abnormal_tail_pigmentation1.86130973
24MP0002254_reproductive_system_inflammat1.82998005
25MP0001929_abnormal_gametogenesis1.71624731
26MP0008789_abnormal_olfactory_epithelium1.70814127
27MP0005423_abnormal_somatic_nervous1.62996769
28MP0001145_abnormal_male_reproductive1.61558967
29MP0005595_abnormal_vascular_smooth1.54145309
30MP0004130_abnormal_muscle_cell1.52353826
31MP0000653_abnormal_sex_gland1.48369404
32MP0001346_abnormal_lacrimal_gland1.46974999
33MP0000631_abnormal_neuroendocrine_gland1.43186103
34MP0005167_abnormal_blood-brain_barrier1.41954525
35MP0008932_abnormal_embryonic_tissue1.40580995
36MP0005409_darkened_coat_color1.39710622
37MP0002653_abnormal_ependyma_morphology1.39705598
38MP0010030_abnormal_orbit_morphology1.38509164
39MP0000470_abnormal_stomach_morphology1.37138247
40MP0005448_abnormal_energy_balance1.36870041
41MP0003724_increased_susceptibility_to1.34008898
42MP0001502_abnormal_circadian_rhythm1.32690630
43MP0004957_abnormal_blastocyst_morpholog1.32167132
44MP0003698_abnormal_male_reproductive1.30875189
45MP0005647_abnormal_sex_gland1.27583481
46MP0003718_maternal_effect1.21393211
47MP0004885_abnormal_endolymph1.20625401
48MP0006082_CNS_inflammation1.19214695
49MP0002638_abnormal_pupillary_reflex1.19032296
50MP0000733_abnormal_muscle_development1.11502543
51MP0000534_abnormal_ureter_morphology1.10698426
52MP0009840_abnormal_foam_cell1.10543915
53MP0009250_abnormal_appendicular_skeleto1.07939329
54MP0000490_abnormal_crypts_of1.05914347
55MP0006035_abnormal_mitochondrial_morpho1.04890010
56MP0001542_abnormal_bone_strength1.04125669
57MP0001119_abnormal_female_reproductive1.01063748
58MP0000230_abnormal_systemic_arterial0.97522910
59MP0003567_abnormal_fetal_cardiomyocyte0.97342684
60MP0003195_calcinosis0.97319802
61MP0006292_abnormal_olfactory_placode0.96970673
62MP0000613_abnormal_salivary_gland0.96708211
63MP0005076_abnormal_cell_differentiation0.95684666
64MP0002277_abnormal_respiratory_mucosa0.95449235
65MP0003699_abnormal_female_reproductive0.94887293
66MP0008058_abnormal_DNA_repair0.94023473
67MP0000015_abnormal_ear_pigmentation0.93917981
68MP0002269_muscular_atrophy0.93900924
69MP0002161_abnormal_fertility/fecundity0.92862440
70MP0004381_abnormal_hair_follicle0.92782072
71MP0002735_abnormal_chemical_nociception0.91998255
72MP0003936_abnormal_reproductive_system0.91182102
73MP0009379_abnormal_foot_pigmentation0.89588852
74MP0003959_abnormal_lean_body0.88428399
75MP0001324_abnormal_eye_pigmentation0.87111532
76MP0005330_cardiomyopathy0.83921533
77MP0002928_abnormal_bile_duct0.82029011
78MP0003755_abnormal_palate_morphology0.81652784
79MP0005623_abnormal_meninges_morphology0.81393999
80MP0004947_skin_inflammation0.79103275
81MP0002163_abnormal_gland_morphology0.78913468
82MP0000026_abnormal_inner_ear0.76252715
83MP0000778_abnormal_nervous_system0.74600195
84MP0001919_abnormal_reproductive_system0.74182367
85MP0005083_abnormal_biliary_tract0.72104851
86MP0002084_abnormal_developmental_patter0.71579362
87MP0005195_abnormal_posterior_eye0.71522372
88MP0001873_stomach_inflammation0.71167628
89MP0001756_abnormal_urination0.70563025
90MP0006276_abnormal_autonomic_nervous0.70555098
91MP0006054_spinal_hemorrhage0.69100652
92MP0002095_abnormal_skin_pigmentation0.68457439
93MP0001664_abnormal_digestion0.67151189
94MP0002116_abnormal_craniofacial_bone0.66925647
95MP0003111_abnormal_nucleus_morphology0.63548108
96MP0005410_abnormal_fertilization0.63207141
97MP0001697_abnormal_embryo_size0.61889398
98MP0002085_abnormal_embryonic_tissue0.58658195
99MP0010094_abnormal_chromosome_stability0.58338374
100MP0000013_abnormal_adipose_tissue0.57762619

Predicted human phenotypes

RankGene SetZ-score
1Posterior subcapsular cataract (HP:0007787)5.13633596
2Reticulocytopenia (HP:0001896)4.71843437
3Lip pit (HP:0100267)4.51038984
4Abnormality of midbrain morphology (HP:0002418)4.17995260
5Molar tooth sign on MRI (HP:0002419)4.17995260
6Colon cancer (HP:0003003)3.88274255
7Microretrognathia (HP:0000308)3.68340541
8Stenosis of the external auditory canal (HP:0000402)3.54891031
9Genetic anticipation (HP:0003743)3.30055532
10Oral leukoplakia (HP:0002745)3.26997206
11Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.14167334
12Abnormality of alanine metabolism (HP:0010916)3.14167334
13Hyperalaninemia (HP:0003348)3.14167334
14Ectopic kidney (HP:0000086)3.03472315
15Prostate neoplasm (HP:0100787)2.97440932
16Subcapsular cataract (HP:0000523)2.92906578
17Pancreatic fibrosis (HP:0100732)2.92323849
18Pancreatic cysts (HP:0001737)2.86210170
19Abnormality of the costochondral junction (HP:0000919)2.83981118
20Anencephaly (HP:0002323)2.78242413
21Median cleft lip (HP:0000161)2.75092036
22True hermaphroditism (HP:0010459)2.67723570
23Chorioretinal atrophy (HP:0000533)2.63740292
24Preaxial hand polydactyly (HP:0001177)2.50063371
25Neoplasm of the oral cavity (HP:0100649)2.47105640
26Type I diabetes mellitus (HP:0100651)2.45309729
27Rectal fistula (HP:0100590)2.45165758
28Rectovaginal fistula (HP:0000143)2.45165758
29Hepatocellular necrosis (HP:0001404)2.40111910
30Abnormality of the renal collecting system (HP:0004742)2.40036130
31Focal segmental glomerulosclerosis (HP:0000097)2.38454394
32Short hallux (HP:0010109)2.37821238
33Abnormality of DNA repair (HP:0003254)2.37024255
34Intestinal fistula (HP:0100819)2.36422393
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.36342689
36Type II lissencephaly (HP:0007260)2.35132767
37Cystic liver disease (HP:0006706)2.34751671
38Optic nerve coloboma (HP:0000588)2.33930376
39Hypoplasia of the uterus (HP:0000013)2.33567943
40Absent thumb (HP:0009777)2.32799051
41Chronic hepatic failure (HP:0100626)2.27340840
42Neoplasm of the adrenal cortex (HP:0100641)2.26527056
43Glomerulosclerosis (HP:0000096)2.20179962
44Abnormal trabecular bone morphology (HP:0100671)2.19477436
45Facial hemangioma (HP:0000329)2.19471639
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.19301512
47Duplicated collecting system (HP:0000081)2.18391629
48Horseshoe kidney (HP:0000085)2.18029111
49Skin pits (HP:0100276)2.17443965
50Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.15095181
51Short 1st metacarpal (HP:0010034)2.15095181
52Short phalanx of the thumb (HP:0009660)2.14701681
53Hypoplasia of the ulna (HP:0003022)2.13907447
54Abnormality of the proximal phalanges of the hand (HP:0009834)2.13624038
55Vaginal fistula (HP:0004320)2.13526537
56Aplasia/Hypoplasia of the hallux (HP:0008362)2.13222971
57Pallor (HP:0000980)2.12356221
58Scotoma (HP:0000575)2.12138240
59Cerebellar dysplasia (HP:0007033)2.11749877
60Abnormality of cells of the erythroid lineage (HP:0012130)2.10750547
61Short tibia (HP:0005736)2.10569739
62Pendular nystagmus (HP:0012043)2.10509194
63Enlarged epiphyses (HP:0010580)2.09800646
64Porencephaly (HP:0002132)2.09343358
65Nephrogenic diabetes insipidus (HP:0009806)2.08379552
66Hypoplasia of the radius (HP:0002984)2.03082303
67Abnormality of the hip-girdle musculature (HP:0001445)2.02010999
68Abnormality of the musculature of the pelvis (HP:0001469)2.02010999
69Wide intermamillary distance (HP:0006610)2.01158196
70Gonadotropin excess (HP:0000837)1.94886931
71Hyperglycemia (HP:0003074)1.90502403
72Dynein arm defect of respiratory motile cilia (HP:0012255)1.89545099
73Absent/shortened dynein arms (HP:0200106)1.89545099
74Hypoplasia of the pons (HP:0012110)1.87339578
75Chromsome breakage (HP:0040012)1.87225942
76Preauricular pit (HP:0004467)1.87210992
77Periauricular skin pits (HP:0100277)1.87210992
78Short thumb (HP:0009778)1.86790448
79Keratoconus (HP:0000563)1.84518257
80Increased corneal curvature (HP:0100692)1.84518257
81Reduced subcutaneous adipose tissue (HP:0003758)1.83163645
82Delayed epiphyseal ossification (HP:0002663)1.82831751
83Metaphyseal irregularity (HP:0003025)1.82800003
84Abnormality of the 1st metacarpal (HP:0010009)1.82695099
85Furrowed tongue (HP:0000221)1.82306166
86Flat occiput (HP:0005469)1.81372021
87Forearm undergrowth (HP:0009821)1.81211916
88Concave nail (HP:0001598)1.80419588
89Aplasia/Hypoplasia of the ulna (HP:0006495)1.79560170
90Persistence of primary teeth (HP:0006335)1.77222874
91Progressive cerebellar ataxia (HP:0002073)1.76745828
92Congenital, generalized hypertrichosis (HP:0004540)1.76539454
93Attenuation of retinal blood vessels (HP:0007843)1.74761983
94Agnosia (HP:0010524)1.73860911
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71655210
96Congenital sensorineural hearing impairment (HP:0008527)1.70516630
97Hepatic necrosis (HP:0002605)1.70238236
98Sclerocornea (HP:0000647)1.69175116
99Congenital hepatic fibrosis (HP:0002612)1.67572891
100Non-midline cleft lip (HP:0100335)1.66980059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF16.11560915
2VRK25.16263226
3ACVR1B4.03281578
4CDK193.46726028
5PDK23.38550115
6SMG13.24733267
7MST42.95840952
8VRK12.81275350
9ZAK2.71834183
10TLK12.58050701
11MAP3K102.38492639
12PNCK2.36218319
13DYRK1B2.29212602
14NUAK12.14479825
15CDK121.78497699
16WNK41.67456038
17WEE11.66279820
18MAPK151.50172353
19CDK91.49516557
20STK161.47750391
21CDC71.36593776
22GRK71.33540755
23NME21.29698072
24ADRBK21.29267615
25MAPKAPK51.23970397
26GRK51.22540349
27BRD41.18523076
28MELK1.15130401
29CSNK1G31.11177428
30CSNK1A1L1.10113651
31ABL21.04538994
32DAPK31.04444545
33CSNK1G11.03210602
34AURKA1.00207871
35IKBKB0.99081438
36CHEK20.98276475
37CSNK1G20.90707873
38NEK90.88764760
39MAPK70.86915759
40RPS6KA50.86101001
41DYRK30.84176922
42TRIM280.83545814
43MET0.80464081
44ICK0.79143718
45CHUK0.76528356
46MST1R0.76425186
47DAPK10.74716091
48PKN10.74132129
49STK110.73194596
50TYRO30.72025542
51ATR0.71274755
52MAPK110.69146128
53MAP3K110.67502657
54STK390.65454101
55IRAK40.63526828
56EPHA30.62966173
57GRK10.62849447
58DYRK1A0.62195602
59IRAK10.60374041
60OXSR10.57596084
61PIM10.55113817
62PLK10.52629283
63GSK3A0.50304474
64IKBKE0.49188849
65WNK10.49061839
66YES10.48926938
67PRKCI0.47294905
68PDGFRB0.46781898
69AURKB0.45603618
70MARK30.44375710
71EIF2AK20.43264797
72PASK0.42236837
73CDK70.41554856
74MAP3K120.41403666
75IRAK20.39967979
76PIM20.39764525
77FRK0.39427908
78MAP3K20.38572814
79MAP3K30.38265288
80CHEK10.38196916
81DYRK20.37780332
82AKT30.36208068
83PLK40.35836797
84PLK20.35402486
85MAP3K50.34122556
86RPS6KA60.33694321
87PRKAA10.33644106
88EPHB20.31566891
89NEK60.29267542
90ADRBK10.29227221
91TBK10.26696655
92PRKCZ0.24827626
93PRKG10.24335125
94PRKCD0.24290904
95BMPR1B0.24045065
96ATM0.23870276
97ERBB40.23387404
98MAP3K80.22933155
99RPS6KA10.21003333
100MKNK20.18514900

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053225.21512419
2Ribosome_Homo sapiens_hsa030103.64991804
3Sulfur relay system_Homo sapiens_hsa041223.44688899
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.34118421
5Alcoholism_Homo sapiens_hsa050343.24327460
6Fanconi anemia pathway_Homo sapiens_hsa034602.82760810
7DNA replication_Homo sapiens_hsa030302.28381563
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.22535861
9p53 signaling pathway_Homo sapiens_hsa041152.22058481
10Selenocompound metabolism_Homo sapiens_hsa004502.18706170
11Basal transcription factors_Homo sapiens_hsa030222.02792498
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.91128837
13Viral carcinogenesis_Homo sapiens_hsa052031.74957425
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65310435
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64439963
16Mismatch repair_Homo sapiens_hsa034301.63022030
17Fatty acid elongation_Homo sapiens_hsa000621.62467518
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58610055
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.57266241
20Sulfur metabolism_Homo sapiens_hsa009201.49744302
21Transcriptional misregulation in cancer_Homo sapiens_hsa052021.48023140
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.47793449
23Dorso-ventral axis formation_Homo sapiens_hsa043201.45196192
24Circadian rhythm_Homo sapiens_hsa047101.32456983
25RNA degradation_Homo sapiens_hsa030181.30563223
26ABC transporters_Homo sapiens_hsa020101.30516421
27Cell cycle_Homo sapiens_hsa041101.30512342
28Asthma_Homo sapiens_hsa053101.23737232
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22080040
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21254212
31Caffeine metabolism_Homo sapiens_hsa002321.19823773
32Homologous recombination_Homo sapiens_hsa034401.19734763
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18247337
34RNA transport_Homo sapiens_hsa030131.14407937
35Linoleic acid metabolism_Homo sapiens_hsa005911.13800769
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13388230
37Protein digestion and absorption_Homo sapiens_hsa049741.09922696
38RNA polymerase_Homo sapiens_hsa030201.08231137
39TGF-beta signaling pathway_Homo sapiens_hsa043501.02084677
40Primary bile acid biosynthesis_Homo sapiens_hsa001200.97679341
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94177406
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91351430
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91007617
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.90714117
45Basal cell carcinoma_Homo sapiens_hsa052170.85876059
46Huntingtons disease_Homo sapiens_hsa050160.85001493
47Nucleotide excision repair_Homo sapiens_hsa034200.83619183
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82942946
49Base excision repair_Homo sapiens_hsa034100.80209433
50Folate biosynthesis_Homo sapiens_hsa007900.77347109
51Nitrogen metabolism_Homo sapiens_hsa009100.77291848
52Chemical carcinogenesis_Homo sapiens_hsa052040.71703186
53Fat digestion and absorption_Homo sapiens_hsa049750.71525849
54Non-homologous end-joining_Homo sapiens_hsa034500.69879136
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68544181
56Retinol metabolism_Homo sapiens_hsa008300.68480974
57Steroid biosynthesis_Homo sapiens_hsa001000.66192256
58mRNA surveillance pathway_Homo sapiens_hsa030150.62791916
59Morphine addiction_Homo sapiens_hsa050320.61326141
60Herpes simplex infection_Homo sapiens_hsa051680.58962020
61Parkinsons disease_Homo sapiens_hsa050120.56170204
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.56143593
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55073397
64Oxidative phosphorylation_Homo sapiens_hsa001900.54046108
65Rheumatoid arthritis_Homo sapiens_hsa053230.53671730
66Small cell lung cancer_Homo sapiens_hsa052220.53366742
67Hedgehog signaling pathway_Homo sapiens_hsa043400.52906939
68Spliceosome_Homo sapiens_hsa030400.52411162
69TNF signaling pathway_Homo sapiens_hsa046680.51974690
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51012966
71Regulation of autophagy_Homo sapiens_hsa041400.48681541
72Purine metabolism_Homo sapiens_hsa002300.48669162
73Olfactory transduction_Homo sapiens_hsa047400.45426701
74Legionellosis_Homo sapiens_hsa051340.44438060
75Cardiac muscle contraction_Homo sapiens_hsa042600.43699652
76Malaria_Homo sapiens_hsa051440.43385360
77Taste transduction_Homo sapiens_hsa047420.42468615
78Starch and sucrose metabolism_Homo sapiens_hsa005000.41586612
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41449551
80Phototransduction_Homo sapiens_hsa047440.40216917
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.39334283
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38739983
83Oocyte meiosis_Homo sapiens_hsa041140.38625775
84Vitamin digestion and absorption_Homo sapiens_hsa049770.37930175
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37415218
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36291326
87Primary immunodeficiency_Homo sapiens_hsa053400.35726229
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35653627
89Melanoma_Homo sapiens_hsa052180.34863693
90Bile secretion_Homo sapiens_hsa049760.32749489
91Ovarian steroidogenesis_Homo sapiens_hsa049130.32486748
92Pyrimidine metabolism_Homo sapiens_hsa002400.32155380
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30640509
94Pancreatic secretion_Homo sapiens_hsa049720.28757117
95Collecting duct acid secretion_Homo sapiens_hsa049660.28667433
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.28666841
97Bladder cancer_Homo sapiens_hsa052190.26913095
98Salivary secretion_Homo sapiens_hsa049700.26540206
99Propanoate metabolism_Homo sapiens_hsa006400.26212399
100Renin-angiotensin system_Homo sapiens_hsa046140.25860522

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