HIGD1AP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mast cell activation (GO:0045576)4.83702506
2sequestering of actin monomers (GO:0042989)4.61260827
3ribosomal small subunit assembly (GO:0000028)4.59814814
4ATP synthesis coupled proton transport (GO:0015986)4.33274356
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.33274356
6respiratory chain complex IV assembly (GO:0008535)4.33242312
7DNA deamination (GO:0045006)4.25011537
8NIK/NF-kappaB signaling (GO:0038061)4.21900966
9regulation of female receptivity (GO:0045924)4.21235315
10mast cell activation involved in immune response (GO:0002279)4.19984691
11mast cell degranulation (GO:0043303)4.19984691
12protein neddylation (GO:0045116)4.01004963
13cullin deneddylation (GO:0010388)3.96654447
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.93220478
15axoneme assembly (GO:0035082)3.82435241
16phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.73035752
17Arp2/3 complex-mediated actin nucleation (GO:0034314)3.65141708
18platelet dense granule organization (GO:0060155)3.63194562
19sleep (GO:0030431)3.60316680
20dopamine transport (GO:0015872)3.54837119
21GPI anchor metabolic process (GO:0006505)3.52975536
22adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.40943264
23female mating behavior (GO:0060180)3.40809009
24regulation of hypersensitivity (GO:0002883)3.39237054
25organic cation transport (GO:0015695)3.38699077
26GPI anchor biosynthetic process (GO:0006506)3.36777351
27positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.32261865
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.31111634
29actin nucleation (GO:0045010)3.28123309
30synaptic transmission, dopaminergic (GO:0001963)3.27629238
31regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.27544908
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.25497056
33T-helper cell differentiation (GO:0042093)3.19962407
34CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.19962407
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.19960766
36cytochrome complex assembly (GO:0017004)3.19292488
37protein deneddylation (GO:0000338)3.18201593
38regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.12070458
39regulation of memory T cell differentiation (GO:0043380)3.07103691
40regulation of activation of Janus kinase activity (GO:0010533)3.06875008
41positive regulation of interleukin-17 production (GO:0032740)3.05578451
42positive regulation of T cell mediated cytotoxicity (GO:0001916)3.04847651
43cytidine deamination (GO:0009972)3.04378596
44cytidine metabolic process (GO:0046087)3.04378596
45cytidine catabolic process (GO:0006216)3.04378596
46positive regulation of T-helper 1 type immune response (GO:0002827)3.04152230
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99515754
48mitochondrial respiratory chain complex I assembly (GO:0032981)2.99515754
49NADH dehydrogenase complex assembly (GO:0010257)2.99515754
50regulation of triglyceride catabolic process (GO:0010896)2.99360402
51positive regulation of alpha-beta T cell proliferation (GO:0046641)2.98548190
52protein complex biogenesis (GO:0070271)2.97047393
53positive regulation of protein homodimerization activity (GO:0090073)2.96664530
54termination of RNA polymerase III transcription (GO:0006386)2.96513704
55transcription elongation from RNA polymerase III promoter (GO:0006385)2.96513704
56T cell receptor signaling pathway (GO:0050852)2.92283432
57respiratory electron transport chain (GO:0022904)2.90770051
58pyrimidine ribonucleoside catabolic process (GO:0046133)2.89223523
59purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.88239317
60electron transport chain (GO:0022900)2.87867926
61alpha-beta T cell differentiation involved in immune response (GO:0002293)2.86418564
62alpha-beta T cell activation involved in immune response (GO:0002287)2.86418564
63T cell differentiation involved in immune response (GO:0002292)2.86418564
64regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.85098561
65neutrophil activation involved in immune response (GO:0002283)2.83858954
66negative regulation of mast cell activation (GO:0033004)2.82621377
67neutrophil activation (GO:0042119)2.80081221
68T cell costimulation (GO:0031295)2.79615028
69regulation of interleukin-8 secretion (GO:2000482)2.77742012
70regulation of T cell mediated cytotoxicity (GO:0001914)2.77328775
71response to gravity (GO:0009629)2.76689634
72positive regulation of interleukin-4 production (GO:0032753)2.76374515
73lymphocyte costimulation (GO:0031294)2.76308139
74regulation of protein glycosylation (GO:0060049)2.71827153
75positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.71164731
76I-kappaB phosphorylation (GO:0007252)2.70511283
77regulation of rhodopsin mediated signaling pathway (GO:0022400)2.70307806
78RNA destabilization (GO:0050779)2.69830208
79positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.67598735
80regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.67598735
81mitochondrial respiratory chain complex assembly (GO:0033108)2.66264332
82hydrogen ion transmembrane transport (GO:1902600)2.62498865
83negative regulation of nitric-oxide synthase activity (GO:0051001)2.61102528
84positive regulation of prostaglandin secretion (GO:0032308)2.59629550
85response to pheromone (GO:0019236)2.58989924
86glycolipid biosynthetic process (GO:0009247)2.57525890
87negative regulation of chemokine production (GO:0032682)2.56670484
88positive regulation of osteoclast differentiation (GO:0045672)2.55150614
89rhodopsin mediated signaling pathway (GO:0016056)2.55041627
90deoxyribonucleotide catabolic process (GO:0009264)2.54400044
91negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.54293673
92immunoglobulin mediated immune response (GO:0016064)2.52411033
93proton transport (GO:0015992)2.52266737
94regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.49759514
95regulation of isotype switching to IgG isotypes (GO:0048302)2.49308246
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.48409237
97deoxyribose phosphate catabolic process (GO:0046386)2.45358530
98regulation of cellular extravasation (GO:0002691)2.45162627
99negative regulation of T cell apoptotic process (GO:0070233)2.45049964
100hydrogen transport (GO:0006818)2.44285839

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.84212389
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.06876054
3VDR_22108803_ChIP-Seq_LS180_Human4.02999024
4EZH2_22144423_ChIP-Seq_EOC_Human4.01235435
5ZNF274_21170338_ChIP-Seq_K562_Hela3.11900567
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.98518908
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.57686361
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53223555
9IGF1R_20145208_ChIP-Seq_DFB_Human2.40136554
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31013971
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29219422
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09823342
13VDR_23849224_ChIP-Seq_CD4+_Human2.00904966
14EST1_17652178_ChIP-ChIP_JURKAT_Human1.96627555
15IRF8_22096565_ChIP-ChIP_GC-B_Human1.85109465
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78179027
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.76567938
18TP53_22573176_ChIP-Seq_HFKS_Human1.66986880
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63963530
20GATA3_26560356_Chip-Seq_TH2_Human1.59580750
21SCL_19346495_ChIP-Seq_HPC-7_Human1.58286867
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56239678
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55507658
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55467513
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52343787
26ELK1_19687146_ChIP-ChIP_HELA_Human1.50398370
27PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.47653436
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.47419260
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45968089
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44590912
31AR_20517297_ChIP-Seq_VCAP_Human1.39002520
32GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38787752
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36327143
34FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36216747
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.36216747
36GATA3_21878914_ChIP-Seq_MCF-7_Human1.36207427
37AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35927841
38MYC_18940864_ChIP-ChIP_HL60_Human1.35239124
39TAF2_19829295_ChIP-Seq_ESCs_Human1.35080285
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34812962
41IRF1_19129219_ChIP-ChIP_H3396_Human1.34137442
42HTT_18923047_ChIP-ChIP_STHdh_Human1.33083316
43EGR1_19032775_ChIP-ChIP_M12_Human1.32290395
44ERG_20517297_ChIP-Seq_VCAP_Human1.27311133
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26880385
46NANOG_19829295_ChIP-Seq_ESCs_Human1.26202044
47SOX2_19829295_ChIP-Seq_ESCs_Human1.26202044
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25918318
49FOXP3_21729870_ChIP-Seq_TREG_Human1.24201314
50CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24088067
51CIITA_25753668_ChIP-Seq_RAJI_Human1.20590457
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20400457
53NANOG_20526341_ChIP-Seq_ESCs_Human1.20353698
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15962497
55NCOR_22424771_ChIP-Seq_293T_Human1.15658100
56MYB_26560356_Chip-Seq_TH2_Human1.15098639
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14785286
58FUS_26573619_Chip-Seq_HEK293_Human1.14551963
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14310514
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.12619182
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09012130
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08799315
63EWS_26573619_Chip-Seq_HEK293_Human1.08717080
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08643219
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06860273
66RNF2_27304074_Chip-Seq_NSC_Mouse1.06580513
67GATA3_27048872_Chip-Seq_THYMUS_Human1.06426715
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06017101
69P300_19829295_ChIP-Seq_ESCs_Human1.05969614
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03721427
71BCAT_22108803_ChIP-Seq_LS180_Human1.02193157
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.01763195
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.00662193
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00081481
75RBPJ_21746931_ChIP-Seq_IB4_Human0.99721106
76ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98332001
77GATA3_26560356_Chip-Seq_TH1_Human0.98148784
78SRF_21415370_ChIP-Seq_HL-1_Mouse0.98102201
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95044829
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94952391
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94810549
82PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94319257
83BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93818704
84GATA6_21074721_ChIP-Seq_CACO-2_Human0.93796717
85ER_23166858_ChIP-Seq_MCF-7_Human0.93194110
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92540934
87ETS1_20019798_ChIP-Seq_JURKAT_Human0.92269978
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91917557
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91917557
90HOXB7_26014856_ChIP-Seq_BT474_Human0.91462232
91BCL6_27268052_Chip-Seq_Bcells_Human0.90862148
92RUNX_20019798_ChIP-Seq_JUKART_Human0.90776848
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89593613
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.87707200
95POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87156263
96ETV1_20927104_ChIP-Seq_GIST48_Human0.87113158
97ERA_21632823_ChIP-Seq_H3396_Human0.86895408
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86380592
99P300_27268052_Chip-Seq_Bcells_Human0.85188999
100RXR_22108803_ChIP-Seq_LS180_Human0.83949512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.77289474
2MP0005671_abnormal_response_to3.08425643
3MP0002166_altered_tumor_susceptibility2.97467578
4MP0003724_increased_susceptibility_to2.78499853
5MP0002006_tumorigenesis2.43536458
6MP0004147_increased_porphyrin_level2.38739156
7MP0006072_abnormal_retinal_apoptosis2.28428154
8MP0009333_abnormal_splenocyte_physiolog2.20173385
9MP0001968_abnormal_touch/_nociception2.11207031
10MP0002736_abnormal_nociception_after2.06968555
11MP0003638_abnormal_response/metabolism_2.05568634
12MP0001835_abnormal_antigen_presentation1.99495575
13MP0002933_joint_inflammation1.83892596
14MP0005000_abnormal_immune_tolerance1.78497974
15MP0009785_altered_susceptibility_to1.77549282
16MP0001919_abnormal_reproductive_system1.74040872
17MP0008875_abnormal_xenobiotic_pharmacok1.70613785
18MP0002163_abnormal_gland_morphology1.63286097
19MP0002837_dystrophic_cardiac_calcinosis1.63128798
20MP0001986_abnormal_taste_sensitivity1.62810756
21MP0001879_abnormal_lymphatic_vessel1.61486724
22MP0009379_abnormal_foot_pigmentation1.59357125
23MP0006036_abnormal_mitochondrial_physio1.54965885
24MP0003436_decreased_susceptibility_to1.52449719
25MP0003787_abnormal_imprinting1.52012909
26MP0002102_abnormal_ear_morphology1.50934995
27MP0005551_abnormal_eye_electrophysiolog1.50872755
28MP0008872_abnormal_physiological_respon1.48872768
29MP0005253_abnormal_eye_physiology1.47837472
30MP0001661_extended_life_span1.43433832
31MP0009764_decreased_sensitivity_to1.41163832
32MP0001905_abnormal_dopamine_level1.40537638
33MP0002148_abnormal_hypersensitivity_rea1.40363170
34MP0002723_abnormal_immune_serum1.39037572
35MP0008995_early_reproductive_senescence1.36110526
36MP0003718_maternal_effect1.35605009
37MP0001800_abnormal_humoral_immune1.33432132
38MP0005389_reproductive_system_phenotype1.33412019
39MP0006276_abnormal_autonomic_nervous1.33000424
40MP0000647_abnormal_sebaceous_gland1.31939556
41MP0002822_catalepsy1.29616109
42MP0000427_abnormal_hair_cycle1.26148523
43MP0008877_abnormal_DNA_methylation1.25800814
44MP0003950_abnormal_plasma_membrane1.22965237
45MP0001819_abnormal_immune_cell1.21853955
46MP0005365_abnormal_bile_salt1.20461916
47MP0002557_abnormal_social/conspecific_i1.20325150
48MP0002420_abnormal_adaptive_immunity1.19365407
49MP0004019_abnormal_vitamin_homeostasis1.18555942
50MP0004885_abnormal_endolymph1.13180721
51MP0005084_abnormal_gallbladder_morpholo1.10890260
52MP0004142_abnormal_muscle_tone1.10710889
53MP0002452_abnormal_antigen_presenting1.10008311
54MP0002095_abnormal_skin_pigmentation1.06992909
55MP0003656_abnormal_erythrocyte_physiolo1.06967507
56MP0001542_abnormal_bone_strength1.06470549
57MP0001765_abnormal_ion_homeostasis1.02916642
58MP0005025_abnormal_response_to1.02486961
59MP0002876_abnormal_thyroid_physiology1.01998746
60MP0002272_abnormal_nervous_system1.00861405
61MP0005646_abnormal_pituitary_gland1.00557294
62MP0000230_abnormal_systemic_arterial0.99887316
63MP0002638_abnormal_pupillary_reflex0.98400295
64MP0009745_abnormal_behavioral_response0.97107540
65MP0004484_altered_response_of0.96809612
66MP0005645_abnormal_hypothalamus_physiol0.96237084
67MP0001845_abnormal_inflammatory_respons0.95944931
68MP0001502_abnormal_circadian_rhythm0.95921562
69MP0001501_abnormal_sleep_pattern0.91121347
70MP0002572_abnormal_emotion/affect_behav0.90959558
71MP0009643_abnormal_urine_homeostasis0.89845022
72MP0010155_abnormal_intestine_physiology0.86938430
73MP0009046_muscle_twitch0.86718609
74MP0001970_abnormal_pain_threshold0.86567972
75MP0008775_abnormal_heart_ventricle0.85965602
76MP0004145_abnormal_muscle_electrophysio0.85607020
77MP0001756_abnormal_urination0.84189043
78MP0006292_abnormal_olfactory_placode0.84003941
79MP0001119_abnormal_female_reproductive0.83762942
80MP0003763_abnormal_thymus_physiology0.82116849
81MP0009765_abnormal_xenobiotic_induced0.82046383
82MP0003866_abnormal_defecation0.81750014
83MP0000465_gastrointestinal_hemorrhage0.81689189
84MP0000716_abnormal_immune_system0.81215410
85MP0008770_decreased_survivor_rate0.80207276
86MP0001984_abnormal_olfaction0.79220750
87MP0000689_abnormal_spleen_morphology0.77854774
88MP0002398_abnormal_bone_marrow0.76432783
89MP0000516_abnormal_urinary_system0.75990416
90MP0005367_renal/urinary_system_phenotyp0.75990416
91MP0000538_abnormal_urinary_bladder0.75942128
92MP0008789_abnormal_olfactory_epithelium0.75333681
93MP0002160_abnormal_reproductive_system0.74921146
94MP0000383_abnormal_hair_follicle0.73922315
95MP0001533_abnormal_skeleton_physiology0.72987657
96MP0008469_abnormal_protein_level0.72693934
97MP0002419_abnormal_innate_immunity0.71719768
98MP0009763_increased_sensitivity_to0.68345863
99MP0008004_abnormal_stomach_pH0.68157148
100MP0004924_abnormal_behavior0.66353559

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)4.16349823
2Decreased electroretinogram (ERG) amplitude (HP:0000654)3.95111131
3Stomach cancer (HP:0012126)3.59790056
4Mitochondrial inheritance (HP:0001427)3.51130118
5True hermaphroditism (HP:0010459)3.47843125
6Pancreatic cysts (HP:0001737)3.44107858
7Amyotrophic lateral sclerosis (HP:0007354)3.42315954
8Hepatic necrosis (HP:0002605)3.40738884
9Acute necrotizing encephalopathy (HP:0006965)3.38595430
10Aplastic anemia (HP:0001915)3.21832368
11Hypoproteinemia (HP:0003075)3.21201835
12Type 2 muscle fiber atrophy (HP:0003554)3.15615288
13Abnormality of the prostate (HP:0008775)3.11590165
14Progressive macrocephaly (HP:0004481)2.98530262
15Constricted visual fields (HP:0001133)2.95778335
16Attenuation of retinal blood vessels (HP:0007843)2.93397015
17Abnormal mitochondria in muscle tissue (HP:0008316)2.89803750
18Abolished electroretinogram (ERG) (HP:0000550)2.84908149
19Acute encephalopathy (HP:0006846)2.84149515
20Pancreatic fibrosis (HP:0100732)2.83167306
21Abnormal biliary tract physiology (HP:0012439)2.80728831
22Bile duct proliferation (HP:0001408)2.80728831
23Hypoplasia of the uterus (HP:0000013)2.79758663
24Increased CSF lactate (HP:0002490)2.79212214
253-Methylglutaconic aciduria (HP:0003535)2.76759750
26Clubbing of toes (HP:0100760)2.72366763
27Muscle fiber atrophy (HP:0100295)2.70397408
28Optic disc pallor (HP:0000543)2.56792961
29Hypothermia (HP:0002045)2.50855183
30Aplasia/hypoplasia of the uterus (HP:0008684)2.47858176
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.42731426
32Abnormality of eosinophils (HP:0001879)2.35456893
33Congenital stationary night blindness (HP:0007642)2.34898790
34Eosinophilia (HP:0001880)2.33992557
35Hypokalemic alkalosis (HP:0001949)2.33063990
36Chromsome breakage (HP:0040012)2.31283771
37Polyphagia (HP:0002591)2.29576521
38Metabolic alkalosis (HP:0200114)2.29426231
39Alveolar cell carcinoma (HP:0006519)2.22341351
40Abnormality of the heme biosynthetic pathway (HP:0010472)2.22305637
41Polyuria (HP:0000103)2.21446992
42Male pseudohermaphroditism (HP:0000037)2.15364688
43Abnormality of the corticospinal tract (HP:0002492)2.15216231
44Atrophy/Degeneration involving motor neurons (HP:0007373)2.14915023
45Dyschromatopsia (HP:0007641)2.14377802
46Abnormality of male internal genitalia (HP:0000022)2.14223605
47Ulnar deviation of the wrist (HP:0003049)2.07813445
48Abnormality of B cell number (HP:0010975)2.06805109
49Increased serum lactate (HP:0002151)2.06744533
50Meckel diverticulum (HP:0002245)2.06497546
51IgG deficiency (HP:0004315)2.06454035
52Thyroid-stimulating hormone excess (HP:0002925)2.01964420
53Abnormality of the ileum (HP:0001549)2.00668514
54Progressive microcephaly (HP:0000253)1.99047184
55Severe combined immunodeficiency (HP:0004430)1.98832522
56Widely patent fontanelles and sutures (HP:0004492)1.97723301
57Thyroiditis (HP:0100646)1.96011264
58Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.94830456
59Generalized aminoaciduria (HP:0002909)1.94079560
60Abnormality of T cell number (HP:0011839)1.92971867
61Panhypogammaglobulinemia (HP:0003139)1.92642880
62Agitation (HP:0000713)1.91344800
63Nemaline bodies (HP:0003798)1.89857539
64Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89778532
65Prostate neoplasm (HP:0100787)1.89719668
66Abnormality of the lower motor neuron (HP:0002366)1.89605551
67Weak cry (HP:0001612)1.89481006
68Cystic liver disease (HP:0006706)1.89082761
69Broad-based gait (HP:0002136)1.88946618
70Congenital, generalized hypertrichosis (HP:0004540)1.88677555
71Pendular nystagmus (HP:0012043)1.87489008
72Hyperlipoproteinemia (HP:0010980)1.86788252
73Lactic acidosis (HP:0003128)1.84516131
74Abnormality of the labia minora (HP:0012880)1.82827438
75Cerebral edema (HP:0002181)1.81613120
76Lissencephaly (HP:0001339)1.81339802
77Abnormality of the renal cortex (HP:0011035)1.80869125
78Abnormal urine output (HP:0012590)1.78356073
79Calf muscle hypertrophy (HP:0008981)1.78297944
80Neoplasm of the tracheobronchial system (HP:0100552)1.78033869
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77465203
82Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77465203
83Abnormality of the preputium (HP:0100587)1.77453810
84Muscle fiber inclusion bodies (HP:0100299)1.77135652
85Oral leukoplakia (HP:0002745)1.76654627
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76209067
87Bony spicule pigmentary retinopathy (HP:0007737)1.76067714
88Popliteal pterygium (HP:0009756)1.75658575
89Respiratory failure (HP:0002878)1.74974101
90Elevated erythrocyte sedimentation rate (HP:0003565)1.74839124
91Abnormal drinking behavior (HP:0030082)1.74146449
92Polydipsia (HP:0001959)1.74146449
93Myotonia (HP:0002486)1.73246479
94IgM deficiency (HP:0002850)1.72235418
95Pancytopenia (HP:0001876)1.71462843
96Poor head control (HP:0002421)1.71214943
97Leukodystrophy (HP:0002415)1.70469617
98Abnormality of chromosome stability (HP:0003220)1.68751231
99Keratoconjunctivitis sicca (HP:0001097)1.68249458
100Granulocytopenia (HP:0001913)1.68200436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.95427243
2CDK194.58697619
3MAP3K123.08334180
4KDR2.71103026
5NUAK12.68691854
6LIMK12.46729232
7TESK22.34842770
8SIK32.30347285
9IKBKE2.16901247
10BMPR22.14296052
11MYLK2.06491697
12CAMKK22.04821608
13ZAK2.04503273
14MAP4K11.94873723
15ERBB31.84885781
16BMPR1B1.73883447
17TAOK31.68550968
18OXSR11.66783602
19STK391.64043603
20MAPK131.61828580
21FRK1.49435586
22MAP2K21.42171986
23ADRBK21.39442301
24PIK3CG1.34551507
25GRK61.28723808
26NEK11.26265000
27WNK41.25207096
28MAP3K141.24344545
29IKBKB1.24006994
30TRPM71.23781812
31ILK1.14933210
32PRKCQ1.02748772
33TESK11.02396143
34TIE11.00221749
35SIK20.99630747
36GRK10.92109473
37RIPK40.91826183
38TLK10.91169944
39LCK0.90832936
40BRSK20.87504390
41RPS6KA40.85720841
42CCNB10.85359743
43MAP3K130.81534322
44WNK30.81459593
45MARK10.80899170
46MAP4K20.80855406
47TXK0.79400155
48MARK30.79355473
49DAPK30.79232958
50SYK0.78643581
51TRIM280.77566085
52CSF1R0.75693567
53MINK10.70579788
54PHKG10.70414155
55PHKG20.70414155
56OBSCN0.69519424
57PRKG10.69299079
58MKNK20.67954468
59LYN0.67622189
60PRKD30.67347307
61CSNK1G20.66316214
62ROCK10.65041554
63CSNK1G30.64950466
64GRK70.62257361
65CAMKK10.61545142
66DYRK20.59083473
67PRKCG0.56449866
68CSNK1A1L0.56294912
69CSNK1G10.56151743
70PRKCE0.55059101
71DAPK10.54836829
72BCR0.53736433
73CSNK1D0.53541861
74MAPK70.52539948
75INSRR0.51941035
76ITK0.49154133
77BRSK10.48184116
78CDK80.48136311
79WNK10.47681280
80BTK0.46561477
81STK110.45666986
82PRKACA0.44441994
83PLK20.44363907
84TEC0.44210068
85PRKCA0.41670208
86GRK50.41148088
87DYRK1A0.38611724
88PASK0.38231029
89RPS6KA20.38004506
90AURKB0.36986002
91IRAK10.36918210
92KIT0.36512099
93EGFR0.36362661
94BCKDK0.35628324
95ZAP700.33246260
96PRKAA20.32841756
97CAMK2D0.32661629
98CDK40.31830239
99CHUK0.30667798
100FES0.30385021

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.03224214
2Allograft rejection_Homo sapiens_hsa053303.48677720
3Graft-versus-host disease_Homo sapiens_hsa053323.39755631
4Autoimmune thyroid disease_Homo sapiens_hsa053203.27249216
5Oxidative phosphorylation_Homo sapiens_hsa001903.17417629
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.03624831
7Type I diabetes mellitus_Homo sapiens_hsa049402.99948269
8Parkinsons disease_Homo sapiens_hsa050122.88841513
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.81233353
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.40821607
11Proteasome_Homo sapiens_hsa030502.23659990
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15982833
13Phototransduction_Homo sapiens_hsa047442.07266195
14Rheumatoid arthritis_Homo sapiens_hsa053231.91542387
15Viral myocarditis_Homo sapiens_hsa054161.87296950
16Primary immunodeficiency_Homo sapiens_hsa053401.74346897
17Ribosome_Homo sapiens_hsa030101.73565201
18Antigen processing and presentation_Homo sapiens_hsa046121.67233214
19Alzheimers disease_Homo sapiens_hsa050101.58668383
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55199189
21Linoleic acid metabolism_Homo sapiens_hsa005911.55086344
22Collecting duct acid secretion_Homo sapiens_hsa049661.55008525
23RNA polymerase_Homo sapiens_hsa030201.53614934
24Cardiac muscle contraction_Homo sapiens_hsa042601.53249174
25One carbon pool by folate_Homo sapiens_hsa006701.45912185
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45300198
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41831000
28Fanconi anemia pathway_Homo sapiens_hsa034601.36249132
29Leishmaniasis_Homo sapiens_hsa051401.29292488
30T cell receptor signaling pathway_Homo sapiens_hsa046601.28055361
31Huntingtons disease_Homo sapiens_hsa050161.27056243
32Olfactory transduction_Homo sapiens_hsa047401.17848829
33Selenocompound metabolism_Homo sapiens_hsa004501.16966436
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15483141
35Staphylococcus aureus infection_Homo sapiens_hsa051501.14885517
36Nitrogen metabolism_Homo sapiens_hsa009101.11471000
37Hematopoietic cell lineage_Homo sapiens_hsa046401.10254427
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02807745
39Arachidonic acid metabolism_Homo sapiens_hsa005901.02423393
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01460209
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99172056
42Folate biosynthesis_Homo sapiens_hsa007900.98486095
43Sulfur relay system_Homo sapiens_hsa041220.92122696
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91379854
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86465464
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83718272
47Ether lipid metabolism_Homo sapiens_hsa005650.83450494
48Morphine addiction_Homo sapiens_hsa050320.83132133
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80204031
50Homologous recombination_Homo sapiens_hsa034400.74037944
51Systemic lupus erythematosus_Homo sapiens_hsa053220.72539006
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.70551512
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67179185
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62656806
55Glutathione metabolism_Homo sapiens_hsa004800.59098826
56Protein export_Homo sapiens_hsa030600.56642470
57Chemical carcinogenesis_Homo sapiens_hsa052040.55426941
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55117525
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53348935
60Herpes simplex infection_Homo sapiens_hsa051680.52630561
61Circadian entrainment_Homo sapiens_hsa047130.52524659
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50913271
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50270555
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49935231
65Salivary secretion_Homo sapiens_hsa049700.46736281
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46493964
67Amphetamine addiction_Homo sapiens_hsa050310.46465798
68Retinol metabolism_Homo sapiens_hsa008300.46023161
69Non-homologous end-joining_Homo sapiens_hsa034500.45777280
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44765328
71Mismatch repair_Homo sapiens_hsa034300.42666933
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.41936546
73Basal transcription factors_Homo sapiens_hsa030220.40398878
74Shigellosis_Homo sapiens_hsa051310.39373442
75Legionellosis_Homo sapiens_hsa051340.39176781
76Regulation of autophagy_Homo sapiens_hsa041400.38285835
77Propanoate metabolism_Homo sapiens_hsa006400.38232100
78Nicotine addiction_Homo sapiens_hsa050330.35630153
79Circadian rhythm_Homo sapiens_hsa047100.32666161
80Tryptophan metabolism_Homo sapiens_hsa003800.31764494
81Tuberculosis_Homo sapiens_hsa051520.30565542
82Epstein-Barr virus infection_Homo sapiens_hsa051690.29461815
83Caffeine metabolism_Homo sapiens_hsa002320.29045253
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.28855466
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28330765
86Gastric acid secretion_Homo sapiens_hsa049710.28024011
87Purine metabolism_Homo sapiens_hsa002300.27421805
88Butanoate metabolism_Homo sapiens_hsa006500.27377273
89Phagosome_Homo sapiens_hsa041450.26531177
90RNA degradation_Homo sapiens_hsa030180.26518577
91Fat digestion and absorption_Homo sapiens_hsa049750.26250925
92Metabolic pathways_Homo sapiens_hsa011000.24865894
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24769283
94Vibrio cholerae infection_Homo sapiens_hsa051100.24216550
95Renin secretion_Homo sapiens_hsa049240.23904767
96Taste transduction_Homo sapiens_hsa047420.20639653
97Influenza A_Homo sapiens_hsa051640.19703612
98Malaria_Homo sapiens_hsa051440.19556255
99GABAergic synapse_Homo sapiens_hsa047270.19294778
100Salmonella infection_Homo sapiens_hsa051320.18864473

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