HIF1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retina vasculature morphogenesis in camera-type eye (GO:0061299)4.12948732
2cellular response to vitamin D (GO:0071305)3.78032560
3positive regulation of natural killer cell differentiation (GO:0032825)3.61527231
4mesodermal cell differentiation (GO:0048333)3.52130426
5cell adhesion mediated by integrin (GO:0033627)3.51674366
6COPII vesicle coating (GO:0048208)3.46361140
7cellular response to interferon-alpha (GO:0035457)3.45781042
8regulation of vitamin D biosynthetic process (GO:0060556)3.41252680
9interleukin-6-mediated signaling pathway (GO:0070102)3.38092865
10platelet-derived growth factor receptor signaling pathway (GO:0048008)3.26264535
11tyrosine phosphorylation of STAT protein (GO:0007260)3.22931865
12membrane raft organization (GO:0031579)3.20179036
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18122012
14retinal rod cell development (GO:0046548)3.16796818
15tolerance induction (GO:0002507)3.12846514
16sequestering of extracellular ligand from receptor (GO:0035581)3.10340247
17collagen fibril organization (GO:0030199)3.09931905
18axon extension involved in axon guidance (GO:0048846)3.08487388
19neuron projection extension involved in neuron projection guidance (GO:1902284)3.08487388
20regulation of transforming growth factor beta1 production (GO:0032908)3.02568165
21regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.01705802
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.98760551
23mesenchymal-epithelial cell signaling (GO:0060638)2.97303141
24negative regulation of chondrocyte differentiation (GO:0032331)2.95706024
25* regulation of transforming growth factor beta2 production (GO:0032909)2.93619187
26Notch signaling involved in heart development (GO:0061314)2.90229947
27growth hormone receptor signaling pathway (GO:0060396)2.89209091
28negative T cell selection (GO:0043383)2.88738805
29lung lobe morphogenesis (GO:0060463)2.87776546
30smooth muscle tissue development (GO:0048745)2.86363675
31UDP-N-acetylglucosamine metabolic process (GO:0006047)2.78836459
32negative thymic T cell selection (GO:0045060)2.78688231
33JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.78252448
34sprouting angiogenesis (GO:0002040)2.77278786
35regulation of vitamin metabolic process (GO:0030656)2.76708633
36regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.75311375
37endodermal cell differentiation (GO:0035987)2.73565188
38membrane protein ectodomain proteolysis (GO:0006509)2.71851132
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.70897017
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70897017
41positive regulation of astrocyte differentiation (GO:0048711)2.69677499
42response to lipoprotein particle (GO:0055094)2.69379982
43dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.67655375
44substrate adhesion-dependent cell spreading (GO:0034446)2.66255692
45wound healing, spreading of epidermal cells (GO:0035313)2.66118130
46positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.65195586
47regulation of membrane protein ectodomain proteolysis (GO:0051043)2.64993648
48positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.64561221
49positive regulation of osteoblast proliferation (GO:0033690)2.64249853
50negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.64091134
51NLS-bearing protein import into nucleus (GO:0006607)2.64042336
52hypotonic response (GO:0006971)2.63308126
53positive regulation of gamma-delta T cell activation (GO:0046645)2.62367878
54chronic inflammatory response (GO:0002544)2.62180991
55glomerular visceral epithelial cell development (GO:0072015)2.60734587
56negative regulation of anoikis (GO:2000811)2.59844237
57regulation of T cell tolerance induction (GO:0002664)2.59329345
58* positive regulation vascular endothelial growth factor production (GO:0010575)2.59075954
59regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.59025995
60glycoprotein catabolic process (GO:0006516)2.58222059
61regulation of interleukin-12 biosynthetic process (GO:0045075)2.57407358
62ganglion development (GO:0061548)2.56787944
63hippo signaling (GO:0035329)2.56437716
64detection of light stimulus involved in sensory perception (GO:0050962)2.55474296
65detection of light stimulus involved in visual perception (GO:0050908)2.55474296
66positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.55124530
67desmosome organization (GO:0002934)2.54678981
68positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.53054560
69cell-substrate junction assembly (GO:0007044)2.52224069
70regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.51117675
71pinocytosis (GO:0006907)2.50767924
72wound healing, spreading of cells (GO:0044319)2.50541323
73substrate-dependent cell migration (GO:0006929)2.48703687
74mammary gland epithelial cell proliferation (GO:0033598)2.47895446
75sodium ion export (GO:0071436)2.47743655
76extracellular matrix disassembly (GO:0022617)2.47537238
77negative regulation of smooth muscle cell migration (GO:0014912)2.47458846
78chondroitin sulfate biosynthetic process (GO:0030206)2.47292828
79nuclear pore complex assembly (GO:0051292)2.47163153
80apoptotic cell clearance (GO:0043277)2.45063022
81negative regulation of axon extension involved in axon guidance (GO:0048843)2.45041496
82protein localization to cell surface (GO:0034394)2.44979379
83cellular response to growth hormone stimulus (GO:0071378)2.44619081
84endothelial cell morphogenesis (GO:0001886)2.44055456
85hemidesmosome assembly (GO:0031581)2.43356097
86cortical actin cytoskeleton organization (GO:0030866)2.42874205
87antigen processing and presentation of endogenous antigen (GO:0019883)2.41425784
88protein localization to endosome (GO:0036010)2.40949677
89response to interleukin-15 (GO:0070672)2.40038319
90response to laminar fluid shear stress (GO:0034616)2.39200944
91cell migration involved in sprouting angiogenesis (GO:0002042)2.38642555
92wound healing (GO:0042060)2.38561069
93vesicle coating (GO:0006901)2.38109429
94positive regulation of chemokine biosynthetic process (GO:0045080)2.37054384
95negative regulation of fatty acid transport (GO:2000192)2.36955871
96heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.36785472
97hepatocyte apoptotic process (GO:0097284)2.36479022
98morphogenesis of an endothelium (GO:0003159)2.36418199
99endothelial tube morphogenesis (GO:0061154)2.36418199
100positive regulation of endothelial cell apoptotic process (GO:2000353)2.36304880
101blood vessel endothelial cell migration (GO:0043534)2.35830156
102regulation of metalloenzyme activity (GO:0048552)2.35545459
103protein heterotrimerization (GO:0070208)2.34641842
104retinal cone cell development (GO:0046549)2.33921148
105myelin assembly (GO:0032288)2.33753733
106negative regulation of nitric oxide biosynthetic process (GO:0045019)2.31952348
107type B pancreatic cell proliferation (GO:0044342)2.31861994
108epithelial cell-cell adhesion (GO:0090136)2.31481096
109response to host (GO:0075136)2.31292284
110response to host defenses (GO:0052200)2.31292284
111response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.31292284
112corticosteroid receptor signaling pathway (GO:0031958)2.30667519
113regulation of integrin-mediated signaling pathway (GO:2001044)2.30345033
114endothelial cell proliferation (GO:0001935)2.30181253
115cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.30001117
116keratan sulfate catabolic process (GO:0042340)2.29504349
117chondrocyte proliferation (GO:0035988)2.29284848
118* regulation of transforming growth factor beta production (GO:0071634)2.29022954
119maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.28696476
120* multicellular organismal macromolecule metabolic process (GO:0044259)2.28650140
121stress fiber assembly (GO:0043149)2.27271790
122positive regulation of p38MAPK cascade (GO:1900745)2.26585716
123regulation of interleukin-2 biosynthetic process (GO:0045076)2.26484954
124pericardium development (GO:0060039)2.25802178
125embryonic process involved in female pregnancy (GO:0060136)2.25745941
126positive regulation of epithelial to mesenchymal transition (GO:0010718)2.25681974
127germ cell migration (GO:0008354)2.25634221
128epithelial cell fate commitment (GO:0072148)2.25202346
129COPI coating of Golgi vesicle (GO:0048205)2.25126824
130Golgi transport vesicle coating (GO:0048200)2.25126824
131skin morphogenesis (GO:0043589)2.25076116
132positive thymic T cell selection (GO:0045059)2.24423749
133cytoplasmic mRNA processing body assembly (GO:0033962)2.24342057
134positive regulation of tolerance induction (GO:0002645)2.24177102
135regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.23804653
136vascular endothelial growth factor signaling pathway (GO:0038084)2.22730093
137* regulation of vascular endothelial growth factor production (GO:0010574)2.22720635
138thymic T cell selection (GO:0045061)2.22533845
139leukocyte aggregation (GO:0070486)2.22340675
140negative regulation of cell killing (GO:0031342)2.18296113
141negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.18296113
142positive regulation of natural killer cell mediated immunity (GO:0002717)2.17690693
143positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.17690693
144epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.16586379
145positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.16463272
146collagen catabolic process (GO:0030574)2.16148156
147photoreceptor cell development (GO:0042461)2.15930852
148modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.13914995
149modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.13914995
150positive regulation by organism of defense response of other organism involved in symbiotic interact2.13914995
151modulation by symbiont of host immune response (GO:0052553)2.13914995
152positive regulation by symbiont of host defense response (GO:0052509)2.13914995
153modulation by symbiont of host defense response (GO:0052031)2.13914995
154* collagen metabolic process (GO:0032963)2.12405053
155decidualization (GO:0046697)2.11402254
156chondrocyte development (GO:0002063)2.11358046
157regulation of natural killer cell differentiation (GO:0032823)2.10415246
158positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.10300816
159cortical cytoskeleton organization (GO:0030865)2.09150813
160fibroblast migration (GO:0010761)2.08889118
161positive regulation of blood vessel endothelial cell migration (GO:0043536)2.08665192
162regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.08663676
163nuclear pore organization (GO:0006999)2.07855828
164T cell selection (GO:0045058)2.07567583
165cellular response to vitamin (GO:0071295)2.07527081
166eye photoreceptor cell development (GO:0042462)2.07293968

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.00093313
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.37106832
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse5.00238747
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.02343076
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.73151616
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.58337388
7HIF1A_21447827_ChIP-Seq_MCF-7_Human2.72487146
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65956303
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.63604018
10CLOCK_20551151_ChIP-Seq_293T_Human2.62755498
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.41186748
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.34091431
13GATA2_21666600_ChIP-Seq_HMVEC_Human2.34045283
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.15971182
15RUNX_20019798_ChIP-Seq_JUKART_Human2.11430049
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.07316866
17SALL4_18804426_ChIP-ChIP_XEN_Mouse2.01215105
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.98494937
19* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92767539
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91891107
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83714667
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.82780916
23JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72016312
24CJUN_26792858_Chip-Seq_BT549_Human1.70708989
25* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.67163054
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.62698896
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.60649596
28RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58078839
29* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57778004
30* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57753742
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.57589829
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.57589829
33TP53_18474530_ChIP-ChIP_U2OS_Human1.57551005
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.57348047
35KDM2B_26808549_Chip-Seq_DND41_Human1.57073954
36MYC_22102868_ChIP-Seq_BL_Human1.55836688
37* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55253905
38* BRD4_25478319_ChIP-Seq_HGPS_Human1.54194602
39ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.52754983
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52305235
41* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51209206
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51069628
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48749805
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44475299
45* UBF1/2_26484160_Chip-Seq_HMECs_Human1.42852534
46* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42214744
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.41686747
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.41498196
49SOX2_20726797_ChIP-Seq_SW620_Human1.41330299
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41094356
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39728333
52* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38818131
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37260185
54AR_21909140_ChIP-Seq_LNCAP_Human1.35992103
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34566522
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34355656
57MYB_26560356_Chip-Seq_TH2_Human1.33062510
58* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31371861
59* TP63_23658742_ChIP-Seq_EP156T_Human1.30635954
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30371954
61* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30251187
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30244923
63* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28793273
64AR_21572438_ChIP-Seq_LNCaP_Human1.28361748
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28305621
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28294940
67TCF7_22412390_ChIP-Seq_EML_Mouse1.28074259
68* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27768671
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26650751
70* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26376076
71* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24422783
72* IRF8_27001747_Chip-Seq_BMDM_Mouse1.24326205
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24321131
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22089792
75* MAF_26560356_Chip-Seq_TH1_Human1.21863004
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.21326665
77AHR_22903824_ChIP-Seq_MCF-7_Human1.21069411
78* EP300_21415370_ChIP-Seq_HL-1_Mouse1.20368979
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20119302
80TP53_16413492_ChIP-PET_HCT116_Human1.18825578
81* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17954037
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17023724
83VDR_24787735_ChIP-Seq_THP-1_Human1.14851130
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14587754
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.14483176
86EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12886806
87UTX_26944678_Chip-Seq_JUKART_Human1.11194033
88FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10560894
89PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10350461
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09677725
91MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08295500
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07991359
93IRF8_21731497_ChIP-ChIP_J774_Mouse1.07812993
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07754344
95JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05790407
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05720699
97ESR1_21235772_ChIP-Seq_MCF-7_Human1.05369610
98* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03976305
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.03061937
100ATF3_27146783_Chip-Seq_COLON_Human1.02904795
101BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02287016
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00846797
103FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99602794
104* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99413053
105ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99298338
106MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98114516
107FLI1_27457419_Chip-Seq_LIVER_Mouse0.98061447
108* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97136681
109ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97125497
110* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96740388
111PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96300436
112MYB_26560356_Chip-Seq_TH1_Human0.94312567
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93789882
114* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93743989
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92708536
116* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92564531
117EZH2_27294783_Chip-Seq_NPCs_Mouse0.92014664
118* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.90362637
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90030064
120ISL1_27105846_Chip-Seq_CPCs_Mouse0.89321102
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.89242011
122GATA3_27048872_Chip-Seq_THYMUS_Human0.88940984
123RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88329365
124* PU_27001747_Chip-Seq_BMDM_Mouse0.87547966
125KDM2B_26808549_Chip-Seq_K562_Human0.87477975
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87141956
127PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87060844
128* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86996491
129SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86939376
130* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86799051
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86543327
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86543327
133NANOG_18555785_Chip-Seq_ESCs_Mouse0.86447738
134CDX2_22108803_ChIP-Seq_LS180_Human0.85456003
135NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85412088
136TBX20_22328084_ChIP-Seq_HEART_Mouse0.85240212
137TBX20_22080862_ChIP-Seq_HEART_Mouse0.85240212

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.09551119
2MP0003705_abnormal_hypodermis_morpholog3.54056411
3MP0003300_gastrointestinal_ulcer2.94519544
4MP0010352_gastrointestinal_tract_polyps2.94203606
5MP0005076_abnormal_cell_differentiation2.54990739
6MP0005275_abnormal_skin_tensile2.51229585
7MP0008004_abnormal_stomach_pH2.39597776
8MP0005503_abnormal_tendon_morphology2.27236517
9MP0003303_peritoneal_inflammation2.20574018
10MP0002933_joint_inflammation2.19661531
11MP0003279_aneurysm2.15584807
12MP0010234_abnormal_vibrissa_follicle2.11698713
13MP0005551_abnormal_eye_electrophysiolog1.99898012
14MP0003091_abnormal_cell_migration1.96711272
15MP0006072_abnormal_retinal_apoptosis1.91464472
16MP0009384_cardiac_valve_regurgitation1.90098586
17MP0005623_abnormal_meninges_morphology1.89729120
18MP0003566_abnormal_cell_adhesion1.85593838
19MP0003011_delayed_dark_adaptation1.80904084
20MP0006054_spinal_hemorrhage1.80403420
21* MP0005023_abnormal_wound_healing1.78928792
22MP0000569_abnormal_digit_pigmentation1.71939929
23MP0000733_abnormal_muscle_development1.70239268
24MP0003828_pulmonary_edema1.68233709
25* MP0003436_decreased_susceptibility_to1.58584822
26MP0005164_abnormal_response_to1.57715677
27MP0002090_abnormal_vision1.57431306
28MP0004272_abnormal_basement_membrane1.56117050
29MP0005253_abnormal_eye_physiology1.55177449
30MP0005248_abnormal_Harderian_gland1.55042304
31MP0003941_abnormal_skin_development1.49475993
32MP0003191_abnormal_cellular_cholesterol1.48401032
33MP0001542_abnormal_bone_strength1.47852352
34MP0001958_emphysema1.45615869
35MP0010030_abnormal_orbit_morphology1.44177506
36MP0005257_abnormal_intraocular_pressure1.41749647
37MP0004947_skin_inflammation1.41688017
38* MP0001533_abnormal_skeleton_physiology1.40557470
39MP0005508_abnormal_skeleton_morphology1.38765452
40MP0003763_abnormal_thymus_physiology1.38095596
41MP0003453_abnormal_keratinocyte_physiol1.35550369
42MP0002166_altered_tumor_susceptibility1.34322495
43MP0010678_abnormal_skin_adnexa1.34221149
44MP0000685_abnormal_immune_system1.32849091
45MP0003045_fibrosis1.32457033
46MP0003950_abnormal_plasma_membrane1.32236783
47* MP0005390_skeleton_phenotype1.29347416
48MP0001243_abnormal_dermal_layer1.28949535
49MP0005671_abnormal_response_to1.27442064
50* MP0003448_altered_tumor_morphology1.25792720
51MP0002998_abnormal_bone_remodeling1.24456678
52MP0002877_abnormal_melanocyte_morpholog1.24309726
53MP0001299_abnormal_eye_distance/1.24275701
54MP0001853_heart_inflammation1.23870450
55MP0000383_abnormal_hair_follicle1.22428134
56MP0001790_abnormal_immune_system1.18530823
57MP0005387_immune_system_phenotype1.18530823
58MP0002168_other_aberrant_phenotype1.18341904
59MP0000537_abnormal_urethra_morphology1.16690098
60MP0002295_abnormal_pulmonary_circulatio1.16678266
61MP0002006_tumorigenesis1.16487181
62MP0009840_abnormal_foam_cell1.16115400
63MP0000428_abnormal_craniofacial_morphol1.15794955
64MP0001346_abnormal_lacrimal_gland1.13797112
65MP0002896_abnormal_bone_mineralization1.13407853
66MP0002060_abnormal_skin_morphology1.12791125
67MP0002405_respiratory_system_inflammati1.11326193
68* MP0005000_abnormal_immune_tolerance1.10109019
69MP0009053_abnormal_anal_canal1.09459757
70MP0001835_abnormal_antigen_presentation1.09445784
71MP0010307_abnormal_tumor_latency1.07755979
72MP0005197_abnormal_uvea_morphology1.07050086
73MP0005195_abnormal_posterior_eye1.05094644
74MP0001324_abnormal_eye_pigmentation1.04108237
75MP0002697_abnormal_eye_size1.02743101
76MP0005391_vision/eye_phenotype1.02247956
77MP0000767_abnormal_smooth_muscle1.00852879
78MP0001849_ear_inflammation1.00314019
79MP0001800_abnormal_humoral_immune0.99822188
80MP0009785_altered_susceptibility_to0.99542638
81MP0004883_abnormal_blood_vessel0.99152217
82MP0001851_eye_inflammation0.99031079
83MP0009278_abnormal_bone_marrow0.98875513
84* MP0010155_abnormal_intestine_physiology0.98524336
85MP0001216_abnormal_epidermal_layer0.96623242
86MP0003795_abnormal_bone_structure0.95606150
87* MP0002452_abnormal_antigen_presenting0.94900090
88* MP0005595_abnormal_vascular_smooth0.94487590
89MP0004233_abnormal_muscle_weight0.94092914
90MP0001915_intracranial_hemorrhage0.93369284
91MP0004510_myositis0.92174640
92MP0004808_abnormal_hematopoietic_stem0.91805561
93MP0002254_reproductive_system_inflammat0.91647900
94MP0006082_CNS_inflammation0.91182049
95* MP0002113_abnormal_skeleton_development0.91072529
96MP0010368_abnormal_lymphatic_system0.88956974
97MP0003385_abnormal_body_wall0.88711314
98* MP0005165_increased_susceptibility_to0.88432043
99MP0009780_abnormal_chondrocyte_physiolo0.88008012
100* MP0002925_abnormal_cardiovascular_devel0.87566045
101MP0002234_abnormal_pharynx_morphology0.87247309
102MP0005621_abnormal_cell_physiology0.86746435
103MP0010386_abnormal_urinary_bladder0.86515396
104MP0001873_stomach_inflammation0.86099225
105MP0003115_abnormal_respiratory_system0.85705036
106MP0000858_altered_metastatic_potential0.85343707
107MP0001879_abnormal_lymphatic_vessel0.83643316
108MP0005058_abnormal_lysosome_morphology0.83380096
109MP0009333_abnormal_splenocyte_physiolog0.83233246
110MP0002148_abnormal_hypersensitivity_rea0.82727534
111MP0000343_altered_response_to0.82638906
112* MP0002282_abnormal_trachea_morphology0.82546056
113* MP0002115_abnormal_skeleton_extremities0.79503444
114MP0003724_increased_susceptibility_to0.78964064
115MP0002089_abnormal_postnatal_growth/wei0.78476740
116MP0004197_abnormal_fetal_growth/weight/0.77091043
117MP0001191_abnormal_skin_condition0.77020630
118MP0009250_abnormal_appendicular_skeleto0.76830418
119MP0000013_abnormal_adipose_tissue0.76543626
120* MP0001614_abnormal_blood_vessel0.75709545
121* MP0000163_abnormal_cartilage_morphology0.74855032
122* MP0002723_abnormal_immune_serum0.74707801
123* MP0000627_abnormal_mammary_gland0.71476629
124MP0009697_abnormal_copulation0.70984029
125MP0000762_abnormal_tongue_morphology0.68707213
126* MP0002128_abnormal_blood_circulation0.67373470
127MP0000432_abnormal_head_morphology0.66571931
128MP0000465_gastrointestinal_hemorrhage0.66047513
129* MP0001175_abnormal_lung_morphology0.65742329
130* MP0000249_abnormal_blood_vessel0.64186706
131MP0005167_abnormal_blood-brain_barrier0.63361713
132MP0003221_abnormal_cardiomyocyte_apopto0.63099410
133* MP0005193_abnormal_anterior_eye0.61513078
134* MP0002133_abnormal_respiratory_system0.60617644
135* MP0005388_respiratory_system_phenotype0.60617644

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.68012679
2Protrusio acetabuli (HP:0003179)4.10163797
3Premature rupture of membranes (HP:0001788)3.63514371
4Central scotoma (HP:0000603)3.53346488
5Aortic aneurysm (HP:0004942)3.48701958
6Vitreoretinal degeneration (HP:0000655)3.47713646
7Aortic dissection (HP:0002647)3.43685002
8Chorioretinal atrophy (HP:0000533)3.31621349
9Bony spicule pigmentary retinopathy (HP:0007737)3.23994016
10Arterial tortuosity (HP:0005116)3.06973357
11Scotoma (HP:0000575)3.00640129
12Cervical subluxation (HP:0003308)2.96547393
13Vascular tortuosity (HP:0004948)2.88674613
14Cerebral aneurysm (HP:0004944)2.86059176
15Persistence of primary teeth (HP:0006335)2.83924741
16Abnormal rod and cone electroretinograms (HP:0008323)2.81697341
17Dilatation of the ascending aorta (HP:0005111)2.81324876
18Atrophic scars (HP:0001075)2.80994473
19Relative macrocephaly (HP:0004482)2.78843009
20Shallow orbits (HP:0000586)2.72006851
21Large earlobe (HP:0009748)2.70567783
22Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.70550786
23Subacute progressive viral hepatitis (HP:0006572)2.69808711
24Increased density of long bones (HP:0006392)2.69806266
25Peritonitis (HP:0002586)2.68576651
26Abnormality of macular pigmentation (HP:0008002)2.68490457
27Short nail (HP:0001799)2.65911016
28Abnormality of dentin (HP:0010299)2.65081147
29Mitral valve prolapse (HP:0001634)2.63745996
30Mitral stenosis (HP:0001718)2.63312645
31Pigmentary retinal degeneration (HP:0001146)2.62757520
32Tetraparesis (HP:0002273)2.58964897
33Vertebral compression fractures (HP:0002953)2.58881128
34Ankle contracture (HP:0006466)2.40967699
35Epiphyseal dysplasia (HP:0002656)2.39959139
36Keratoconus (HP:0000563)2.38187726
37Increased corneal curvature (HP:0100692)2.38187726
38Myocardial infarction (HP:0001658)2.37186933
39Pendular nystagmus (HP:0012043)2.35978678
40Soft skin (HP:0000977)2.33242441
41Hypoplastic ischia (HP:0003175)2.28329606
42Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.24727673
43Abolished electroretinogram (ERG) (HP:0000550)2.24084999
44Genu recurvatum (HP:0002816)2.22499283
45Bladder diverticulum (HP:0000015)2.20703922
46Delayed closure of the anterior fontanelle (HP:0001476)2.19422087
47Aneurysm (HP:0002617)2.14100638
48Posterior subcapsular cataract (HP:0007787)2.12460017
49Eczematoid dermatitis (HP:0000976)2.11923516
50Severe visual impairment (HP:0001141)2.06753292
51Cone-rod dystrophy (HP:0000548)2.05448724
52Aortic regurgitation (HP:0001659)2.04782703
53Absent frontal sinuses (HP:0002688)2.04677310
54Rhizomelia (HP:0008905)2.04614542
55Pulmonic stenosis (HP:0001642)2.02623097
56Spinal rigidity (HP:0003306)2.02162238
57Abnormality of the ischium (HP:0003174)2.01346549
58Neonatal short-limb short stature (HP:0008921)2.00469029
59Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99916786
60Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.99468757
61Abnormality of skull ossification (HP:0002703)1.96431871
62Spondylolisthesis (HP:0003302)1.95833261
63Abnormality of the distal phalanges of the toes (HP:0010182)1.95631704
64Natal tooth (HP:0000695)1.95286878
65Exostoses (HP:0100777)1.95129881
66Decreased skull ossification (HP:0004331)1.94728979
67Interstitial pulmonary disease (HP:0006530)1.94306330
68Abnormality of the acetabulum (HP:0003170)1.93900873
69Abnormality of the frontal sinuses (HP:0002687)1.92503166
70Radial bowing (HP:0002986)1.92325748
71Wormian bones (HP:0002645)1.91623255
72Cupped ribs (HP:0000887)1.89563044
73Abnormality of the peritoneum (HP:0002585)1.89346060
74Osteolytic defects of the hand bones (HP:0009699)1.86167927
75Osteolytic defects of the phalanges of the hand (HP:0009771)1.86167927
76Hematochezia (HP:0002573)1.85874951
77Abnormality of glycolipid metabolism (HP:0010969)1.84541363
78Abnormality of liposaccharide metabolism (HP:0010968)1.84541363
79Abnormality of glycosphingolipid metabolism (HP:0004343)1.84541363
80Blue sclerae (HP:0000592)1.81917764
81Asymmetry of the thorax (HP:0001555)1.81074363
82Cardiovascular calcification (HP:0011915)1.80271293
83Mesomelia (HP:0003027)1.79983078
84Ulnar bowing (HP:0003031)1.78680062
85Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78525522
86Thoracolumbar scoliosis (HP:0002944)1.76641154
87Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.76205492
88Broad metatarsal (HP:0001783)1.76164693
89Aortic valve stenosis (HP:0001650)1.75756969
90Ovoid vertebral bodies (HP:0003300)1.75355850
91Hand muscle atrophy (HP:0009130)1.74572987
92Broad face (HP:0000283)1.74435275
93Broad ribs (HP:0000885)1.74099766
94Short 4th metacarpal (HP:0010044)1.73959131
95Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.73959131
96Limited elbow extension (HP:0001377)1.73384116
97Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.70405959
98Elbow flexion contracture (HP:0002987)1.68935746
99Tibial bowing (HP:0002982)1.68828960
100Thin bony cortex (HP:0002753)1.68322007
101Wrist flexion contracture (HP:0001239)1.68025606
102Striae distensae (HP:0001065)1.67983340
103Osteoarthritis (HP:0002758)1.67252581
104Thick nail (HP:0001805)1.66337048
105Short clavicles (HP:0000894)1.66150731
106Hallux valgus (HP:0001822)1.66034310
107Arterial thrombosis (HP:0004420)1.65842294
108Mitral regurgitation (HP:0001653)1.65699128
109Ectopia lentis (HP:0001083)1.65539459
110T lymphocytopenia (HP:0005403)1.64793756
111Fragile skin (HP:0001030)1.64467841
112Deviation of the hallux (HP:0010051)1.63807859
113Delayed cranial suture closure (HP:0000270)1.63647046
114Orchitis (HP:0100796)1.63602930
115Flared iliac wings (HP:0002869)1.62909574
116Papillary thyroid carcinoma (HP:0002895)1.62524634
117Protruding ear (HP:0000411)1.62293114
118Pectus carinatum (HP:0000768)1.62079362
119Follicular hyperkeratosis (HP:0007502)1.61544066
120Milia (HP:0001056)1.61444722
121Bowel diverticulosis (HP:0005222)1.61178945
122Abnormality of T cell number (HP:0011839)1.60439261
123Joint laxity (HP:0001388)1.59895975
124Syringomyelia (HP:0003396)1.59664360
125Spinal cord lesions (HP:0100561)1.59664360
126Deviation of the thumb (HP:0009603)1.59455330
127Coarse hair (HP:0002208)1.58806454
128Scapular winging (HP:0003691)1.58287751
129Abnormality of carpal bone ossification (HP:0006257)1.57164877
130Abnormal vertebral ossification (HP:0100569)1.56170166
131Alopecia of scalp (HP:0002293)1.56038050
132Inguinal hernia (HP:0000023)1.55269926
133Type II diabetes mellitus (HP:0005978)1.55160986
134Micronodular cirrhosis (HP:0001413)1.55158213
135Myositis (HP:0100614)1.55080517
136Camptodactyly of toe (HP:0001836)1.54533674
137Upper limb amyotrophy (HP:0009129)1.53723718
138Distal upper limb amyotrophy (HP:0007149)1.53723718
139Narrow palate (HP:0000189)1.53598433
140Hyperextensible skin (HP:0000974)1.53527815
141Photophobia (HP:0000613)1.52427066
142Emphysema (HP:0002097)1.52350635
143Disproportionate tall stature (HP:0001519)1.52298463
144Abnormal delivery (HP:0001787)1.51516721
145Short humerus (HP:0005792)1.51346396
146Overgrowth (HP:0001548)1.51123685
147Bicuspid aortic valve (HP:0001647)1.50825608
148Broad long bones (HP:0005622)1.50726205
149Periodontitis (HP:0000704)1.50500042
150Dysostosis multiplex (HP:0000943)1.50083326
151Ureteral obstruction (HP:0006000)1.50000643
152Dyschromatopsia (HP:0007641)1.49967450
153Reduced subcutaneous adipose tissue (HP:0003758)1.49059014
154Spastic diplegia (HP:0001264)1.48647999
155Mucopolysacchariduria (HP:0008155)1.47961024
156Urinary glycosaminoglycan excretion (HP:0003541)1.47961024
157Coxa vara (HP:0002812)1.47121527

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.00414093
2FGFR42.79037210
3EPHA32.66518029
4JAK32.64493765
5IRAK32.60943159
6PKN22.56356591
7PDGFRA2.54002810
8DDR22.53509162
9ERBB42.42328664
10FGFR32.30110345
11TRIB32.17847320
12RIPK11.99504348
13TXK1.99288918
14TTN1.97496839
15LMTK21.92153223
16JAK11.88148738
17LATS11.86155171
18CDK121.81025882
19STK101.80317270
20ITK1.80236056
21MAP3K101.77445840
22RPS6KA41.72304345
23PTK61.71470125
24TIE11.69543475
25EPHB11.67256637
26TYK21.67186516
27SCYL21.62371310
28BCR1.59993015
29MAP3K141.59888706
30STK38L1.57881898
31FGFR11.53359611
32EEF2K1.46088880
33SIK31.45824873
34FER1.45758051
35MYLK1.44682422
36MAP4K11.37395314
37LRRK21.37063299
38PDGFRB1.34688843
39CAMK1D1.34241802
40PRPF4B1.33599917
41FGFR21.30186034
42KSR11.29961359
43DMPK1.29034949
44NEK91.23813527
45TRIM281.22919932
46BMX1.22724840
47STK31.17534721
48CHUK1.17484486
49PBK1.17373253
50NTRK11.15417868
51AKT31.14872142
52TGFBR11.11807964
53TYRO31.10915175
54LIMK11.10363112
55PDK21.09616319
56TBK11.08867852
57SIK11.08311444
58BMPR21.08167503
59ERN11.05832901
60BRSK21.04952251
61MAP3K31.03450776
62TGFBR21.02125965
63CDK60.97880198
64MAP3K130.96246121
65MELK0.96148636
66PLK20.95701367
67STK240.94537623
68CDK80.93901876
69RET0.93264396
70CAMK1G0.93158978
71IRAK10.93059751
72PTK20.92937043
73MAP3K120.92438436
74CSK0.91533571
75JAK20.89333658
76CDK90.88146734
77EIF2AK20.85283733
78EIF2AK10.84302754
79ZAP700.84249313
80MST40.83926400
81MTOR0.79818920
82PAK20.79783431
83ERBB30.79429898
84MST1R0.78172286
85GRK70.77854057
86STK380.77566175
87KSR20.76337021
88PAK30.75993407
89IKBKE0.75667887
90TRPM70.74646598
91EPHB20.74627245
92CLK10.73817455
93TAOK20.73427067
94LCK0.72934960
95HCK0.72486172
96ALK0.72102536
97MARK30.71677100
98MET0.71127624
99PRKCH0.70152229
100BRD40.66907906
101EGFR0.66035359
102CDC42BPA0.66015266
103PAK40.65424022
104HIPK20.65231959
105TESK10.64480902
106MAP3K80.63974171
107PRKCE0.63221122
108KDR0.61596324
109FRK0.57690221
110DYRK1B0.56993002
111INSR0.56965339
112MAPK70.55436995
113NLK0.53354236
114ABL20.53269699
115MKNK10.52419265
116IKBKB0.51362324
117ERBB20.51165749
118MAP3K60.50336464
119PAK60.50212980
120EPHA20.49922332
121MAP3K20.48490673
122PIK3CA0.48393191
123BMPR1B0.47529076
124PRKG20.47168609
125FLT30.46709473
126ROCK20.45363276
127ABL10.45104870
128RPS6KB20.44750667
129NEK60.44531470
130IGF1R0.44427419
131MAP3K50.43738532
132MAP3K70.43425985
133CSNK1A1L0.43251399
134SRC0.41646064
135NEK10.41440924
136MKNK20.41102539
137ROCK10.40002658
138GSK3A0.38950738
139NUAK10.38856071
140KIT0.37456022
141SGK30.37308955
142LATS20.34516163
143MOS0.34418829
144CDK40.34351707

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.46697239
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20097993
3ECM-receptor interaction_Homo sapiens_hsa045121.85271876
4Leishmaniasis_Homo sapiens_hsa051401.68996269
5Viral myocarditis_Homo sapiens_hsa054161.67816299
6Malaria_Homo sapiens_hsa051441.64420128
7Other glycan degradation_Homo sapiens_hsa005111.63778959
8TNF signaling pathway_Homo sapiens_hsa046681.62773773
9Autoimmune thyroid disease_Homo sapiens_hsa053201.61766721
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.60193093
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.60153629
12Adherens junction_Homo sapiens_hsa045201.58142202
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.57732419
14Focal adhesion_Homo sapiens_hsa045101.57361063
15T cell receptor signaling pathway_Homo sapiens_hsa046601.55801958
16Small cell lung cancer_Homo sapiens_hsa052221.54047497
17Chronic myeloid leukemia_Homo sapiens_hsa052201.53620277
18Allograft rejection_Homo sapiens_hsa053301.50572758
19Osteoclast differentiation_Homo sapiens_hsa043801.49275680
20Toxoplasmosis_Homo sapiens_hsa051451.49241193
21* Proteoglycans in cancer_Homo sapiens_hsa052051.45441843
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.45336914
23MicroRNAs in cancer_Homo sapiens_hsa052061.40747528
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.38725600
25Measles_Homo sapiens_hsa051621.35333766
26Pancreatic cancer_Homo sapiens_hsa052121.31741817
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.27820400
28Legionellosis_Homo sapiens_hsa051341.26201455
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.22961959
30Hepatitis B_Homo sapiens_hsa051611.17991814
31Asthma_Homo sapiens_hsa053101.17990039
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17753681
33Graft-versus-host disease_Homo sapiens_hsa053321.17059996
34Lysosome_Homo sapiens_hsa041421.16945107
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16893219
36Amoebiasis_Homo sapiens_hsa051461.14420009
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13574771
38Hippo signaling pathway_Homo sapiens_hsa043901.12116977
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11905750
40Shigellosis_Homo sapiens_hsa051311.11079348
41HTLV-I infection_Homo sapiens_hsa051661.10933234
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10561949
43Notch signaling pathway_Homo sapiens_hsa043301.09908421
44TGF-beta signaling pathway_Homo sapiens_hsa043501.07690881
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06291250
46Salmonella infection_Homo sapiens_hsa051321.05107516
47Antigen processing and presentation_Homo sapiens_hsa046121.04203304
48Colorectal cancer_Homo sapiens_hsa052101.02945816
49Chemokine signaling pathway_Homo sapiens_hsa040621.02676397
50* Renal cell carcinoma_Homo sapiens_hsa052111.01730142
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01287929
52Sphingolipid metabolism_Homo sapiens_hsa006001.00992477
53* HIF-1 signaling pathway_Homo sapiens_hsa040661.00943417
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00687419
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.00125917
56* Central carbon metabolism in cancer_Homo sapiens_hsa052300.99869756
57Thyroid cancer_Homo sapiens_hsa052160.99661405
58Viral carcinogenesis_Homo sapiens_hsa052030.98585031
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98528052
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98084706
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97968220
62Dilated cardiomyopathy_Homo sapiens_hsa054140.94828215
63Influenza A_Homo sapiens_hsa051640.91785544
64VEGF signaling pathway_Homo sapiens_hsa043700.91079184
65Apoptosis_Homo sapiens_hsa042100.90446564
66Prolactin signaling pathway_Homo sapiens_hsa049170.89936857
67Hematopoietic cell lineage_Homo sapiens_hsa046400.89012318
68African trypanosomiasis_Homo sapiens_hsa051430.88895946
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88726220
70Primary immunodeficiency_Homo sapiens_hsa053400.88667844
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88353370
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88303033
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87426117
74Steroid biosynthesis_Homo sapiens_hsa001000.87056400
75Rheumatoid arthritis_Homo sapiens_hsa053230.85922528
76Herpes simplex infection_Homo sapiens_hsa051680.85773538
77* mTOR signaling pathway_Homo sapiens_hsa041500.85605020
78Tuberculosis_Homo sapiens_hsa051520.85068507
79* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84918685
80Circadian rhythm_Homo sapiens_hsa047100.84848528
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84184317
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81003257
83B cell receptor signaling pathway_Homo sapiens_hsa046620.80397026
84Protein digestion and absorption_Homo sapiens_hsa049740.79393273
85Glioma_Homo sapiens_hsa052140.78923508
86Bladder cancer_Homo sapiens_hsa052190.77439390
87Platelet activation_Homo sapiens_hsa046110.77332327
88Prostate cancer_Homo sapiens_hsa052150.77008910
89Endometrial cancer_Homo sapiens_hsa052130.76935699
90* Pathways in cancer_Homo sapiens_hsa052000.75164198
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74265002
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.74205413
93Acute myeloid leukemia_Homo sapiens_hsa052210.73912517
94Pertussis_Homo sapiens_hsa051330.73764646
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72522142
96Type I diabetes mellitus_Homo sapiens_hsa049400.71992951
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71648532
98Dorso-ventral axis formation_Homo sapiens_hsa043200.70240013
99Basal cell carcinoma_Homo sapiens_hsa052170.69540395
100Complement and coagulation cascades_Homo sapiens_hsa046100.69472919
101Vibrio cholerae infection_Homo sapiens_hsa051100.67995268
102Endocytosis_Homo sapiens_hsa041440.67081431
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.66017043
104Phagosome_Homo sapiens_hsa041450.65236897
105Rap1 signaling pathway_Homo sapiens_hsa040150.63912867
106Non-small cell lung cancer_Homo sapiens_hsa052230.63107963
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60533722
108Sulfur metabolism_Homo sapiens_hsa009200.60278385
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59706883
110p53 signaling pathway_Homo sapiens_hsa041150.59394857
111Insulin resistance_Homo sapiens_hsa049310.58329022
112Melanoma_Homo sapiens_hsa052180.58196699
113Hepatitis C_Homo sapiens_hsa051600.57083416
114Galactose metabolism_Homo sapiens_hsa000520.57012142
115Non-homologous end-joining_Homo sapiens_hsa034500.56859241
116N-Glycan biosynthesis_Homo sapiens_hsa005100.56009293
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55967162
118MAPK signaling pathway_Homo sapiens_hsa040100.54975810
119Tight junction_Homo sapiens_hsa045300.54154444
120FoxO signaling pathway_Homo sapiens_hsa040680.53027655
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51214765
122ErbB signaling pathway_Homo sapiens_hsa040120.49777866
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.46705368
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46225774

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