HIC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukocyte aggregation (GO:0070486)6.30316033
2protein heterotrimerization (GO:0070208)6.10092853
3CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.34941259
4cardiac myofibril assembly (GO:0055003)4.77122473
5collagen fibril organization (GO:0030199)4.57409483
6bone trabecula formation (GO:0060346)4.48092609
7glycoprotein catabolic process (GO:0006516)4.37840239
8plasma membrane repair (GO:0001778)4.23985398
9negative regulation of fatty acid transport (GO:2000192)4.20664621
10chondrocyte proliferation (GO:0035988)4.01814258
11endodermal cell differentiation (GO:0035987)3.98536740
12skin morphogenesis (GO:0043589)3.95591101
13regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.94682965
14myeloid dendritic cell differentiation (GO:0043011)3.88122424
15basement membrane organization (GO:0071711)3.83375174
16positive regulation of macrophage cytokine production (GO:0060907)3.82393047
17neuron projection extension involved in neuron projection guidance (GO:1902284)3.80170757
18axon extension involved in axon guidance (GO:0048846)3.80170757
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.78040091
20cell proliferation involved in metanephros development (GO:0072203)3.76928353
21collagen metabolic process (GO:0032963)3.76493223
22vascular endothelial growth factor signaling pathway (GO:0038084)3.74906910
23B cell homeostasis (GO:0001782)3.73036629
24sarcomere organization (GO:0045214)3.70968053
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.66412822
26myofibril assembly (GO:0030239)3.64885052
27induction of positive chemotaxis (GO:0050930)3.61789893
28collagen catabolic process (GO:0030574)3.61782260
29response to type I interferon (GO:0034340)3.59338687
30trabecula formation (GO:0060343)3.55737324
31T-helper 1 type immune response (GO:0042088)3.54730206
32antigen processing and presentation of endogenous antigen (GO:0019883)3.54719450
33type I interferon signaling pathway (GO:0060337)3.53418627
34cellular response to type I interferon (GO:0071357)3.53418627
35polarized epithelial cell differentiation (GO:0030859)3.53079331
36multicellular organismal macromolecule metabolic process (GO:0044259)3.52397568
37regulation of B cell receptor signaling pathway (GO:0050855)3.51432441
38planar cell polarity pathway involved in neural tube closure (GO:0090179)3.50961945
39regulation of tight junction assembly (GO:2000810)3.50887744
40positive regulation of gamma-delta T cell activation (GO:0046645)3.47897594
41T cell lineage commitment (GO:0002360)3.44559784
42cell migration involved in heart development (GO:0060973)3.41990581
43hematopoietic stem cell differentiation (GO:0060218)3.41656522
44sequestering of extracellular ligand from receptor (GO:0035581)3.40592990
45insulin-like growth factor receptor signaling pathway (GO:0048009)3.39769906
46regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.39252989
47cell migration involved in sprouting angiogenesis (GO:0002042)3.37270876
48multicellular organismal catabolic process (GO:0044243)3.33686076
49interferon-gamma-mediated signaling pathway (GO:0060333)3.33536781
50multicellular organismal metabolic process (GO:0044236)3.32613713
51positive regulation of humoral immune response (GO:0002922)3.31289820
52cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.31131435
53hippo signaling (GO:0035329)3.31119939
54rRNA transcription (GO:0009303)3.31108276
55cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.30372310
56regulation of dendritic cell antigen processing and presentation (GO:0002604)3.29413670
57gonadal mesoderm development (GO:0007506)3.29378180
58regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.28145647
59positive regulation of glycogen biosynthetic process (GO:0045725)3.27945013
60vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.27692057
61regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.27091104
62apoptotic cell clearance (GO:0043277)3.26603860
63heart trabecula formation (GO:0060347)3.26313347
64positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.24919025
65positive regulation of defense response to virus by host (GO:0002230)3.23952440
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.23769395
67myeloid dendritic cell activation (GO:0001773)3.23567174
68endocardial cushion development (GO:0003197)3.22315005
69positive regulation by symbiont of host defense response (GO:0052509)3.22227194
70modulation by symbiont of host defense response (GO:0052031)3.22227194
71modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.22227194
72modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.22227194
73positive regulation by organism of defense response of other organism involved in symbiotic interact3.22227194
74modulation by symbiont of host immune response (GO:0052553)3.22227194
75metanephric mesenchyme development (GO:0072075)3.21072822
76kidney mesenchyme development (GO:0072074)3.20304885
77regulation of apoptotic process involved in morphogenesis (GO:1902337)3.19071217
78extracellular fibril organization (GO:0043206)3.16899268
79extracellular matrix disassembly (GO:0022617)3.15730412
80regulation of macrophage cytokine production (GO:0010935)3.15668727
81B cell receptor signaling pathway (GO:0050853)3.12234922
82regulation of lymphocyte migration (GO:2000401)3.10794218
83glomerular basement membrane development (GO:0032836)3.09976013
84NIK/NF-kappaB signaling (GO:0038061)3.08795076
85nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.08683401
86immunoglobulin mediated immune response (GO:0016064)3.07325139
87UV protection (GO:0009650)3.07159248
88positive regulation of endothelial cell apoptotic process (GO:2000353)3.07023117
89negative regulation of chondrocyte differentiation (GO:0032331)3.05430869
90positive regulation of epithelial to mesenchymal transition (GO:0010718)3.03646220
91adherens junction assembly (GO:0034333)3.00603181
92regulation of interferon-gamma biosynthetic process (GO:0045072)2.99576082
93adhesion of symbiont to host (GO:0044406)2.98531945
94epithelial cell-cell adhesion (GO:0090136)2.98406396
95blood vessel endothelial cell migration (GO:0043534)2.97865179
96adhesion of symbiont to host cell (GO:0044650)2.97734627
97virion attachment to host cell (GO:0019062)2.97734627
98positive regulation of fatty acid beta-oxidation (GO:0032000)2.96904810
99G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.94065091
100anatomical structure regression (GO:0060033)2.92334224
101stress fiber assembly (GO:0043149)2.92301880
102cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.91649308
103blood vessel maturation (GO:0001955)2.90750770
104cell proliferation involved in kidney development (GO:0072111)2.90098290
105T cell migration (GO:0072678)2.89450285
106regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.89361591
107fibril organization (GO:0097435)2.88409672
108heart morphogenesis (GO:0003007)2.87708296
109actomyosin structure organization (GO:0031032)2.87028405
110wound healing, spreading of epidermal cells (GO:0035313)2.86712698
111cell-substrate junction assembly (GO:0007044)2.84562475
112macroautophagy (GO:0016236)2.84393173
113regulation of fatty acid beta-oxidation (GO:0031998)2.83800882
114glomerular filtration (GO:0003094)2.81196494
115atrioventricular valve morphogenesis (GO:0003181)2.80406667
116positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.80258319
117cardiac muscle cell proliferation (GO:0060038)2.80258286
118regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.78419280
119positive regulation of histone deacetylation (GO:0031065)2.78034212
120mesenchyme morphogenesis (GO:0072132)2.78016302
121negative regulation of catenin import into nucleus (GO:0035414)2.77740704
122negative regulation of phagocytosis (GO:0050765)2.76892576
123positive regulation of glycogen metabolic process (GO:0070875)2.76353628
124maternal placenta development (GO:0001893)2.75951577
125negative regulation of cell size (GO:0045792)2.75430283
126regulation of antigen processing and presentation (GO:0002577)2.75233075
127retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74238774
128response to muramyl dipeptide (GO:0032495)2.73787183
129negative regulation of adherens junction organization (GO:1903392)2.72540832
130negative regulation of focal adhesion assembly (GO:0051895)2.72540832
131negative regulation of cell junction assembly (GO:1901889)2.72540832
132focal adhesion assembly (GO:0048041)2.71285471
133cell-substrate adherens junction assembly (GO:0007045)2.71285471
134macrophage activation involved in immune response (GO:0002281)2.69619442
135protein hydroxylation (GO:0018126)2.69098668
136renal filtration (GO:0097205)2.68665963
137positive regulation of immunoglobulin mediated immune response (GO:0002891)2.67997639
138positive regulation of B cell mediated immunity (GO:0002714)2.67997639
139positive regulation of Rho protein signal transduction (GO:0035025)2.67965588
140lung vasculature development (GO:0060426)2.67874935
141detection of bacterium (GO:0016045)2.67796986
142peptidyl-proline hydroxylation (GO:0019511)2.67524491
143negative regulation of cartilage development (GO:0061037)2.67435263
144T cell costimulation (GO:0031295)2.66736434
145antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.66555599
146morphogenesis of an endothelium (GO:0003159)2.66404585
147endothelial tube morphogenesis (GO:0061154)2.66404585
148positive regulation of vascular permeability (GO:0043117)2.65991719
149lung lobe morphogenesis (GO:0060463)2.64769982
150positive regulation of blood vessel endothelial cell migration (GO:0043536)2.64031046
151dendritic cell differentiation (GO:0097028)2.62542775
152negative regulation of cardiac muscle tissue growth (GO:0055022)2.62294434
153negative regulation of heart growth (GO:0061117)2.62294434
154lymphocyte costimulation (GO:0031294)2.62185991
155regulation of p38MAPK cascade (GO:1900744)2.62054023
156regulation of gamma-delta T cell activation (GO:0046643)2.60195455
157extracellular matrix assembly (GO:0085029)2.59594174
158craniofacial suture morphogenesis (GO:0097094)2.59521088
159positive regulation of fatty acid oxidation (GO:0046321)2.58946344
160negative regulation of bone remodeling (GO:0046851)2.58567440
161defense response to protozoan (GO:0042832)2.57691712
162response to protozoan (GO:0001562)2.57365636
163cardiac muscle cell development (GO:0055013)2.56776649
164mesenchyme development (GO:0060485)2.56721782
165negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.54484247
166response to fluid shear stress (GO:0034405)2.53497952
167lymphocyte homeostasis (GO:0002260)2.52513853
168positive regulation of protein kinase C signaling (GO:0090037)2.50136877
169paraxial mesoderm development (GO:0048339)2.49463754
170regulation of cartilage development (GO:0061035)2.49249550
171negative regulation of bone resorption (GO:0045779)2.49106902
172regulation of fatty acid oxidation (GO:0046320)2.48527204
173cell adhesion mediated by integrin (GO:0033627)2.48347137
174cellular response to interferon-gamma (GO:0071346)2.45696511
175lymphocyte migration (GO:0072676)2.45372108
176cytidine deamination (GO:0009972)2.44547430
177cytidine metabolic process (GO:0046087)2.44547430
178cytidine catabolic process (GO:0006216)2.44547430
179positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.44354652
180negative regulation of B cell proliferation (GO:0030889)2.44022187
181venous blood vessel morphogenesis (GO:0048845)2.43688795
182negative regulation of interleukin-12 production (GO:0032695)2.43138882
183regulation of interferon-beta biosynthetic process (GO:0045357)2.42612111
184detection of other organism (GO:0098543)2.42470611
185SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.40996974
186positive thymic T cell selection (GO:0045059)2.37825042
187regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.37461385
188regulation of natural killer cell mediated immunity (GO:0002715)2.37461385
189activation of MAPKKK activity (GO:0000185)10.6997347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.27860445
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.08117221
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.79622828
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.75337233
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.65278985
6CLOCK_20551151_ChIP-Seq_293T_Human3.31349629
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.10770077
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.08193945
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.95654963
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.82839880
11TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.79629392
12* ELK3_25401928_ChIP-Seq_HUVEC_Human2.68519735
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.62084545
14RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.59190823
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.47323836
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.46075094
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.40195609
18* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.30423893
19* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.12260240
20* KDM2B_26808549_Chip-Seq_DND41_Human2.04344608
21EP300_21415370_ChIP-Seq_HL-1_Mouse2.04142004
22HIF1A_21447827_ChIP-Seq_MCF-7_Human2.03449160
23VDR_24763502_ChIP-Seq_THP-1_Human2.01927677
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.93822182
25CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.92411395
26MYC_22102868_ChIP-Seq_BL_Human1.91561135
27TBX20_22080862_ChIP-Seq_HEART_Mouse1.90907600
28TBX20_22328084_ChIP-Seq_HEART_Mouse1.90907600
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88786606
30* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86318323
31LXR_22292898_ChIP-Seq_THP-1_Human1.82909571
32* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77202755
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75561654
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74950387
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74756140
36* RACK7_27058665_Chip-Seq_MCF-7_Human1.74170342
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73823753
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72931301
39ZNF263_19887448_ChIP-Seq_K562_Human1.70839162
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70204938
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69222612
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68434758
43TCF7_22412390_ChIP-Seq_EML_Mouse1.68341313
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.67150005
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.64788715
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.64231370
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63763292
48ATF3_27146783_Chip-Seq_COLON_Human1.62537678
49NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.61800216
50DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.60474561
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.58365384
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56324166
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56066886
54RUNX_20019798_ChIP-Seq_JUKART_Human1.52938273
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52604304
56* KDM2B_26808549_Chip-Seq_JURKAT_Human1.50532578
57PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50386766
58* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50148197
59KDM2B_26808549_Chip-Seq_K562_Human1.48908620
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48355853
61* BRD4_25478319_ChIP-Seq_HGPS_Human1.48016351
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47966518
63* MAF_26560356_Chip-Seq_TH2_Human1.47894635
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46637828
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.45420133
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45245419
67TP53_22127205_ChIP-Seq_IMR90_Human1.44130357
68* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42782284
69CJUN_26792858_Chip-Seq_BT549_Human1.42561418
70* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.42389172
71VDR_21846776_ChIP-Seq_THP-1_Human1.41842864
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39888551
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39863654
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39323566
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39204045
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.38594587
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.37731847
78NFIB_24661679_ChIP-Seq_LUNG_Mouse1.37295835
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.36719613
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36462463
81* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36080301
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35879395
83FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.35817334
84ISL1_27105846_Chip-Seq_CPCs_Mouse1.35717939
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.34234015
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32296816
87IRF8_21731497_ChIP-ChIP_J774_Mouse1.32294472
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32216062
89CIITA_25753668_ChIP-Seq_RAJI_Human1.31750964
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28824888
91STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26185367
92MAF_26560356_Chip-Seq_TH1_Human1.23278061
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.23230208
94MYB_26560356_Chip-Seq_TH2_Human1.22796412
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.22458204
96MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.21330516
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20935735
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20809770
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20645170
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20284633
101PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18797263
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18772632
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18722161
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18722161
105IRF8_27001747_Chip-Seq_BMDM_Mouse1.18520682
106CREB1_26743006_Chip-Seq_LNCaP_Human1.18039431
107NCOR1_26117541_ChIP-Seq_K562_Human1.16651001
108RUNX1_27514584_Chip-Seq_MCF-7_Human1.16647802
109STAT1_20625510_ChIP-Seq_HELA_Human1.14543180
110SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14310692
111CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13992513
112ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13601535
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13016579
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11785049
115ESR1_21235772_ChIP-Seq_MCF-7_Human1.11709193
116MYB_26560356_Chip-Seq_TH1_Human1.11709088
117FOXO3_23340844_ChIP-Seq_DLD1_Human1.11532864
118LXR_22158963_ChIP-Seq_LIVER_Mouse1.11049245
119RXR_22158963_ChIP-Seq_LIVER_Mouse1.10684098
120UTX_26944678_Chip-Seq_JUKART_Human1.07978575
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07272684
122DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07188334
123* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06821688
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06779597
125* TP53_23651856_ChIP-Seq_MEFs_Mouse1.06709207
126BP1_19119308_ChIP-ChIP_Hs578T_Human1.06231101
127* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06055326
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05833906
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05781541
130* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05764351
131NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05262348
132RUNX1_22412390_ChIP-Seq_EML_Mouse1.04486602
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02266161
134TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01222505
135SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00874623
136CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98932801
137GATA1_19941826_ChIP-Seq_K562_Human0.98753252
138ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98583762
139SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98139678
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97262833
141DROSHA_22980978_ChIP-Seq_HELA_Human0.96945965
142TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96378251
143SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96136352
144EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95786140
145FOXM1_23109430_ChIP-Seq_U2OS_Human0.94412607
146GATA2_21666600_ChIP-Seq_HMVEC_Human0.94243501
147MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93198330
148* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92779399
149TET1_21451524_ChIP-Seq_MESCs_Mouse0.92438591
150GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91581393
151LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90328086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.31967625
2MP0003705_abnormal_hypodermis_morpholog4.09422532
3MP0005275_abnormal_skin_tensile3.72160355
4MP0005503_abnormal_tendon_morphology3.72104109
5MP0003279_aneurysm3.54668274
6MP0000685_abnormal_immune_system3.29448786
7MP0004272_abnormal_basement_membrane3.07777219
8MP0005671_abnormal_response_to3.03455542
9MP0006054_spinal_hemorrhage2.78338064
10MP0005387_immune_system_phenotype2.61794570
11MP0001790_abnormal_immune_system2.61794570
12MP0001958_emphysema2.47506144
13MP0004084_abnormal_cardiac_muscle2.36715199
14MP0000751_myopathy2.31495633
15MP0002837_dystrophic_cardiac_calcinosis2.28520337
16MP0003303_peritoneal_inflammation2.24701966
17MP0010368_abnormal_lymphatic_system2.24139703
18MP0001800_abnormal_humoral_immune2.23360949
19MP0003566_abnormal_cell_adhesion2.21505052
20MP0002138_abnormal_hepatobiliary_system2.04313957
21MP0005000_abnormal_immune_tolerance1.98808342
22MP0003436_decreased_susceptibility_to1.89274044
23MP0001835_abnormal_antigen_presentation1.88939225
24MP0003763_abnormal_thymus_physiology1.87441605
25MP0005508_abnormal_skeleton_morphology1.84465652
26MP0002166_altered_tumor_susceptibility1.83961484
27MP0000733_abnormal_muscle_development1.83509637
28MP0005023_abnormal_wound_healing1.71787503
29MP0009384_cardiac_valve_regurgitation1.68595902
30* MP0003385_abnormal_body_wall1.68305230
31MP0002452_abnormal_antigen_presenting1.65463673
32MP0010030_abnormal_orbit_morphology1.63311043
33MP0002723_abnormal_immune_serum1.59420854
34MP0005330_cardiomyopathy1.58628218
35MP0000767_abnormal_smooth_muscle1.57773393
36MP0000750_abnormal_muscle_regeneration1.52300665
37* MP0005623_abnormal_meninges_morphology1.49950562
38MP0010630_abnormal_cardiac_muscle1.48599073
39MP0004087_abnormal_muscle_fiber1.48271869
40MP0002060_abnormal_skin_morphology1.48219042
41MP0003091_abnormal_cell_migration1.47461573
42MP0005076_abnormal_cell_differentiation1.44458190
43MP0002420_abnormal_adaptive_immunity1.43974105
44MP0003122_maternal_imprinting1.43343289
45MP0002108_abnormal_muscle_morphology1.42925416
46MP0006138_congestive_heart_failure1.42618525
47MP0009250_abnormal_appendicular_skeleto1.41109536
48MP0001819_abnormal_immune_cell1.40953196
49MP0008775_abnormal_heart_ventricle1.40797611
50MP0005645_abnormal_hypothalamus_physiol1.40289215
51MP0010352_gastrointestinal_tract_polyps1.35473759
52MP0003115_abnormal_respiratory_system1.34403238
53MP0000013_abnormal_adipose_tissue1.32769927
54MP0004036_abnormal_muscle_relaxation1.31696743
55MP0009785_altered_susceptibility_to1.31333233
56MP0000534_abnormal_ureter_morphology1.31164556
57MP0005025_abnormal_response_to1.31074119
58MP0005385_cardiovascular_system_phenoty1.30417479
59MP0001544_abnormal_cardiovascular_syste1.30417479
60MP0003942_abnormal_urinary_system1.28534977
61MP0003828_pulmonary_edema1.27649342
62MP0009053_abnormal_anal_canal1.26155290
63MP0005257_abnormal_intraocular_pressure1.26043850
64MP0000428_abnormal_craniofacial_morphol1.25876911
65MP0010155_abnormal_intestine_physiology1.25030837
66MP0003941_abnormal_skin_development1.24999112
67MP0002128_abnormal_blood_circulation1.23946321
68MP0003567_abnormal_fetal_cardiomyocyte1.23268440
69MP0002006_tumorigenesis1.18796696
70MP0001879_abnormal_lymphatic_vessel1.18079316
71MP0000759_abnormal_skeletal_muscle1.15516658
72MP0000003_abnormal_adipose_tissue1.15418766
73MP0001243_abnormal_dermal_layer1.15336667
74MP0002419_abnormal_innate_immunity1.13928873
75MP0002932_abnormal_joint_morphology1.13790021
76MP0000749_muscle_degeneration1.12000729
77MP0001873_stomach_inflammation1.11840795
78MP0002295_abnormal_pulmonary_circulatio1.10894791
79MP0002896_abnormal_bone_mineralization1.08894432
80MP0009333_abnormal_splenocyte_physiolog1.08553167
81MP0004510_myositis1.08244527
82MP0004215_abnormal_myocardial_fiber1.07190880
83MP0000716_abnormal_immune_system1.06848175
84MP0002972_abnormal_cardiac_muscle1.06027101
85* MP0004947_skin_inflammation1.05832686
86MP0003300_gastrointestinal_ulcer1.03898783
87MP0010307_abnormal_tumor_latency1.03125395
88MP0000266_abnormal_heart_morphology1.02677046
89MP0002925_abnormal_cardiovascular_devel1.01743813
90MP0003045_fibrosis1.01412073
91MP0002398_abnormal_bone_marrow1.01393935
92MP0009278_abnormal_bone_marrow1.01065830
93MP0001533_abnormal_skeleton_physiology1.00767521
94MP0005369_muscle_phenotype0.99921703
95MP0002282_abnormal_trachea_morphology0.99347356
96MP0000762_abnormal_tongue_morphology0.99204761
97MP0002106_abnormal_muscle_physiology0.97900297
98MP0001614_abnormal_blood_vessel0.96548720
99MP0005375_adipose_tissue_phenotype0.96132867
100MP0005620_abnormal_muscle_contractility0.96016738
101MP0005164_abnormal_response_to0.95024694
102MP0003123_paternal_imprinting0.94732562
103MP0002249_abnormal_larynx_morphology0.94659555
104MP0001845_abnormal_inflammatory_respons0.94545337
105MP0003283_abnormal_digestive_organ0.94482844
106MP0004233_abnormal_muscle_weight0.93837726
107MP0000249_abnormal_blood_vessel0.93083584
108MP0005390_skeleton_phenotype0.93077532
109MP0002148_abnormal_hypersensitivity_rea0.91430911
110MP0002933_joint_inflammation0.89386207
111MP0003448_altered_tumor_morphology0.89382511
112MP0003724_increased_susceptibility_to0.89019941
113MP0004134_abnormal_chest_morphology0.88460147
114MP0005595_abnormal_vascular_smooth0.88091652
115MP0000163_abnormal_cartilage_morphology0.87283996
116MP0000343_altered_response_to0.87102054
117MP0005451_abnormal_body_composition0.85345532
118MP0001348_abnormal_lacrimal_gland0.84947947
119* MP0003935_abnormal_craniofacial_develop0.84627324
120MP0002115_abnormal_skeleton_extremities0.83779160
121MP0000537_abnormal_urethra_morphology0.83635154
122MP0002405_respiratory_system_inflammati0.83522459
123MP0002429_abnormal_blood_cell0.83501451
124MP0000049_abnormal_middle_ear0.82270984
125MP0000689_abnormal_spleen_morphology0.81360912
126MP0000516_abnormal_urinary_system0.80666507
127MP0005367_renal/urinary_system_phenotyp0.80666507
128MP0002113_abnormal_skeleton_development0.79992302
129MP0004185_abnormal_adipocyte_glucose0.79581866
130MP0005666_abnormal_adipose_tissue0.79056537
131MP0009764_decreased_sensitivity_to0.77699139
132MP0001175_abnormal_lung_morphology0.77352001
133MP0005670_abnormal_white_adipose0.77276005
134MP0001542_abnormal_bone_strength0.76754953
135* MP0000858_altered_metastatic_potential0.76584811
136MP0003795_abnormal_bone_structure0.76226531
137MP0004130_abnormal_muscle_cell0.75933508
138MP0005165_increased_susceptibility_to0.75905317
139MP0001915_intracranial_hemorrhage0.75263503
140MP0002722_abnormal_immune_system0.73377647
141MP0008874_decreased_physiological_sensi0.72889279
142MP0009379_abnormal_foot_pigmentation0.72416952
143MP0002127_abnormal_cardiovascular_syste0.72298550
144MP0008469_abnormal_protein_level0.71225130
145MP0002998_abnormal_bone_remodeling0.70995087
146MP0002168_other_aberrant_phenotype0.70991686
147MP0002269_muscular_atrophy0.70539511
148* MP0004197_abnormal_fetal_growth/weight/0.70017086
149MP0005584_abnormal_enzyme/coenzyme_acti0.69741125
150MP0002234_abnormal_pharynx_morphology0.68917271

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.38919142
2Fatigue (HP:0012378)6.73527844
3Retinal atrophy (HP:0001105)6.58764957
4Premature rupture of membranes (HP:0001788)6.57717151
5Cerebellar dysplasia (HP:0007033)5.84657047
6Ankle contracture (HP:0006466)5.25301568
7Type II lissencephaly (HP:0007260)4.88172103
8Hypoplasia of the pons (HP:0012110)4.77400606
9Shallow orbits (HP:0000586)4.68902108
10Gastrointestinal stroma tumor (HP:0100723)4.64898757
11Broad metatarsal (HP:0001783)4.63790122
12Retinal dysplasia (HP:0007973)4.45235784
13Aortic dissection (HP:0002647)4.44319755
14Cerebral aneurysm (HP:0004944)4.32738215
15Abnormality of the pons (HP:0007361)4.19267221
16Increased connective tissue (HP:0009025)4.12350587
17IgA deficiency (HP:0002720)4.01679206
18Type 1 muscle fiber predominance (HP:0003803)3.98966841
19Bladder diverticulum (HP:0000015)3.94945508
20Emphysema (HP:0002097)3.86048068
21Peritonitis (HP:0002586)3.83594579
22Congenital glaucoma (HP:0001087)3.57496764
23Soft skin (HP:0000977)3.53475651
24Atrophic scars (HP:0001075)3.50813070
25Fragile skin (HP:0001030)3.49277353
26Entropion (HP:0000621)3.48406653
27Mitral valve prolapse (HP:0001634)3.45178342
28Aortic aneurysm (HP:0004942)3.44757757
29Aplasia/Hypoplasia affecting the retina (HP:0008061)3.42085696
30Megalocornea (HP:0000485)3.38021404
31Dilatation of the ascending aorta (HP:0005111)3.34618001
32Spinal rigidity (HP:0003306)3.27435407
33Follicular hyperkeratosis (HP:0007502)3.20753304
34Decreased electroretinogram (ERG) amplitude (HP:0000654)3.15064192
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.12522586
36Short 4th metacarpal (HP:0010044)3.12522586
37IgG deficiency (HP:0004315)3.07893990
38Blue sclerae (HP:0000592)3.07615098
39Increased variability in muscle fiber diameter (HP:0003557)3.07067034
40Right ventricular cardiomyopathy (HP:0011663)2.97082772
41Slender build (HP:0001533)2.94491572
42Abnormality of the 4th metacarpal (HP:0010012)2.90911446
43Mildly elevated creatine phosphokinase (HP:0008180)2.89645335
44Wrist flexion contracture (HP:0001239)2.88876943
45Muscle fiber splitting (HP:0003555)2.88467414
46Genu recurvatum (HP:0002816)2.88306854
47Abnormality of dentin (HP:0010299)2.77832286
48Ventricular tachycardia (HP:0004756)2.77671224
49Neonatal short-limb short stature (HP:0008921)2.75743552
50Increased IgM level (HP:0003496)2.73496946
51Abnormality of skeletal muscle fiber size (HP:0012084)2.67962337
52Aneurysm (HP:0002617)2.66529648
53Bowel diverticulosis (HP:0005222)2.65904560
54Agammaglobulinemia (HP:0004432)2.65633280
55Spontaneous hematomas (HP:0007420)2.62057024
56Recurrent sinusitis (HP:0011108)2.61382550
57Generalized hypotonia (HP:0001290)2.61135177
58Sudden death (HP:0001699)2.59339259
59Cervical subluxation (HP:0003308)2.58568961
60Recurrent bronchitis (HP:0002837)2.57676818
61Camptodactyly of toe (HP:0001836)2.49990756
62Wormian bones (HP:0002645)2.47008914
63Wide anterior fontanel (HP:0000260)2.45912869
64Cellulitis (HP:0100658)2.45802712
65Decreased subcutaneous fat (HP:0001002)2.44243259
66Biconcave vertebral bodies (HP:0004586)2.44178787
67Generalized muscle weakness (HP:0003324)2.43511580
68Thin bony cortex (HP:0002753)2.42779850
69Lymphangioma (HP:0100764)2.42146063
70Vertebral compression fractures (HP:0002953)2.41905581
71Renal duplication (HP:0000075)2.40705838
72Deviation of the hallux (HP:0010051)2.39268545
73Recurrent lower respiratory tract infections (HP:0002783)2.37455908
74Lipoatrophy (HP:0100578)2.35896615
75Hallux valgus (HP:0001822)2.35709603
76Joint laxity (HP:0001388)2.35167765
77Hyperextensible skin (HP:0000974)2.34566378
78Lymphopenia (HP:0001888)2.34081523
79Restrictive lung disease (HP:0002091)2.30848674
80Ectopia lentis (HP:0001083)2.29719804
81Muscle stiffness (HP:0003552)2.29264636
82IgM deficiency (HP:0002850)2.26891234
83Abnormality of the peritoneum (HP:0002585)2.26427287
84Asymmetry of the thorax (HP:0001555)2.26402997
85Poikiloderma (HP:0001029)2.25498435
86Overgrowth (HP:0001548)2.22674622
87Abnormality of cells of the lymphoid lineage (HP:0012140)2.21321931
88Striae distensae (HP:0001065)2.19696772
89Gowers sign (HP:0003391)2.18339454
90Conical tooth (HP:0000698)2.17672011
91Elbow flexion contracture (HP:0002987)2.16151559
92Long toe (HP:0010511)2.14128283
93Rectal prolapse (HP:0002035)2.13392992
94Difficulty climbing stairs (HP:0003551)2.12132709
95Vasculitis (HP:0002633)2.11218165
96Ulnar bowing (HP:0003031)2.11053151
97Increased density of long bones (HP:0006392)2.09817449
98Disproportionate tall stature (HP:0001519)2.08944423
99Hyporeflexia of lower limbs (HP:0002600)2.08789515
100Generalized amyotrophy (HP:0003700)2.06943466
101Meningitis (HP:0001287)2.06189650
102Subaortic stenosis (HP:0001682)2.05667438
103Abnormality of the left ventricular outflow tract (HP:0011103)2.05667438
104Abnormal delivery (HP:0001787)2.05186839
105Nonimmune hydrops fetalis (HP:0001790)2.04968704
106Mitral regurgitation (HP:0001653)2.04270186
107Muscular dystrophy (HP:0003560)2.04062518
108Flexion contracture of toe (HP:0005830)1.99811799
109Joint contractures involving the joints of the feet (HP:0100492)1.99811799
110Distal arthrogryposis (HP:0005684)1.98415845
111Hyperacusis (HP:0010780)1.97797593
112Mesangial abnormality (HP:0001966)1.96640867
113Abnormality of the acetabulum (HP:0003170)1.95233429
114Venous abnormality (HP:0002624)1.94891071
115Spondylolisthesis (HP:0003302)1.93914007
116Abnormality of vision evoked potentials (HP:0000649)1.93152626
117Atrial fibrillation (HP:0005110)1.91821716
118Severe muscular hypotonia (HP:0006829)1.91428356
119Buphthalmos (HP:0000557)1.89726560
120Flat cornea (HP:0007720)1.89280303
121Renovascular hypertension (HP:0100817)1.88723061
122Abnormality of incisor morphology (HP:0011063)1.87428561
123Abnormality of the calf musculature (HP:0001430)1.87356187
124Persistence of primary teeth (HP:0006335)1.86229881
125Enlarged penis (HP:0000040)1.85287045
126Scapular winging (HP:0003691)1.84734580
127Supraventricular arrhythmia (HP:0005115)1.83888369
128Delayed closure of the anterior fontanelle (HP:0001476)1.83266277
129Osteolytic defects of the hand bones (HP:0009699)1.82564696
130Osteolytic defects of the phalanges of the hand (HP:0009771)1.82564696
131Venous insufficiency (HP:0005293)1.81858330
132Primary atrial arrhythmia (HP:0001692)1.81234935
133Selective tooth agenesis (HP:0001592)1.80855915
134Achilles tendon contracture (HP:0001771)1.80420809
135Round ear (HP:0100830)1.80393920
136Slow saccadic eye movements (HP:0000514)1.80316262
137Limb-girdle muscle weakness (HP:0003325)1.80196620
138Colitis (HP:0002583)1.78281271
139Hypergammaglobulinemia (HP:0010702)1.77675838
140Abnormality of the right ventricle (HP:0001707)1.76724422
141Slender long bone (HP:0003100)1.76523086
142Vascular tortuosity (HP:0004948)1.75707277
143Eczematoid dermatitis (HP:0000976)1.75372559
144Hematochezia (HP:0002573)1.75273295
145Pulmonary infiltrates (HP:0002113)1.74863427
146Pulmonary artery stenosis (HP:0004415)1.74656980
147Broad ribs (HP:0000885)1.74342380
148Knee flexion contracture (HP:0006380)1.73303176
149Hemorrhage of the eye (HP:0011885)1.72404657
150Supraventricular tachycardia (HP:0004755)1.72232574
151Hypoventilation (HP:0002791)1.71365488
152Spinal cord lesions (HP:0100561)1.70430394
153Ulnar deviation of the wrist (HP:0003049)1.69855563
154Aortic regurgitation (HP:0001659)1.68859517
155Recurrent pneumonia (HP:0006532)1.66336984
156Recurrent viral infections (HP:0004429)1.66244918
157Submucous cleft hard palate (HP:0000176)1.65589631
158Arterial tortuosity (HP:0005116)1.64672242
159Abolished electroretinogram (ERG) (HP:0000550)1.64510707

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.81259987
2MARK34.63904272
3TTN4.46732443
4PKN24.13706425
5PRPF4B3.84509976
6PDGFRA3.23836672
7ERN12.70685586
8LATS22.66532444
9EEF2K2.56021596
10LATS12.50221388
11RIPK42.31231777
12DMPK2.29456263
13MAP3K102.24676369
14DDR22.17545001
15RIPK12.15400593
16MAP3K142.14169729
17MAP3K132.14000965
18MYLK2.10401074
19SIK12.07134622
20EPHB22.01612465
21PTK61.93917335
22PIM11.88204574
23SMG11.85886394
24EPHA31.71792213
25PAK21.65236045
26EPHB11.54342254
27TAOK21.52927670
28TGFBR21.40191134
29TIE11.40090069
30BMX1.39304741
31MAPK71.38554076
32KDR1.36783965
33IKBKB1.36295199
34ILK1.34761033
35FGFR41.32808669
36PTK21.31957875
37LRRK21.29863303
38TYK21.29333916
39LMTK21.25521950
40SIK21.25511529
41STK111.24809214
42IKBKE1.19628098
43PTK2B1.19076943
44MTOR1.16490911
45PDGFRB1.13925257
46PAK41.09311149
47IRAK41.07187815
48NLK1.04818471
49CDK121.04271783
50TLK11.01341211
51MELK1.00489013
52RPS6KA40.97528373
53PRKD10.96499358
54ICK0.94259055
55FER0.91959763
56STK30.91558736
57TGFBR10.91371578
58SYK0.91020716
59MAPK120.89276044
60MAPK110.88538233
61PAK30.87464538
62NEK90.86958065
63TAOK10.83910517
64TRPM70.83554495
65HIPK20.83160967
66CSF1R0.82168049
67BLK0.81451201
68MAP3K70.79316454
69ROCK10.79164742
70JAK30.78950017
71PIK3CA0.78851551
72CDC42BPA0.77070214
73PRKD20.75848182
74FGFR10.74945505
75PRKCH0.74218731
76PIM20.74069243
77PIK3CG0.69448401
78FLT30.69203791
79MAPK40.66123866
80RET0.66018367
81JAK10.65022704
82DAPK30.64828083
83MET0.62123070
84MAP2K30.62000085
85MAP4K10.59482959
86AKT30.57087440
87STK100.56290393
88BTK0.54546102
89ROCK20.54388486
90CAMK1D0.53993532
91ZAP700.53132147
92MAP3K30.52646956
93LYN0.51691750
94STK38L0.51165473
95CDK60.51074810
96PRKCQ0.49585676
97CDK40.48185049
98CAMK1G0.48109493
99KIT0.47573552
100FGFR30.47323752
101TBK10.47092027
102MATK0.46649360
103STK240.46614110
104PHKG20.46267664
105PHKG10.46267664
106MAP3K80.45598746
107PDPK10.45305841
108CHUK0.45267885
109MAPKAPK20.44952225
110ALK0.44110763
111PRKD30.43511726
112LCK0.43497406
113CLK10.43134943
114IRAK30.43002397
115TXK0.40904308
116RPS6KA60.40095824
117RPS6KC10.39212973
118RPS6KL10.39212973
119HCK0.38805439
120IRAK10.38779364
121WNK10.37138672
122MAP2K20.35966417
123PRKG20.35443261
124PKN10.35379774
125CSK0.34214784
126TYRO30.33361137
127RPS6KA50.32431580
128GSK3A0.32197908
129MARK20.31865440
130SRC0.31585053
131PAK10.31291529
132DYRK1B0.30216310
133FGFR20.30194920
134INSR0.29522936
135MAPK10.29404187
136ITK0.29367724
137RPS6KA20.28883173
138STK380.28638639
139RPS6KA10.28474615
140NEK20.26580367
141AKT20.26469634
142MAP2K10.26207265

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046723.92478772
2Allograft rejection_Homo sapiens_hsa053303.67658877
3ECM-receptor interaction_Homo sapiens_hsa045123.63390164
4Graft-versus-host disease_Homo sapiens_hsa053323.40578292
5Autoimmune thyroid disease_Homo sapiens_hsa053203.28381833
6Asthma_Homo sapiens_hsa053103.21180959
7Focal adhesion_Homo sapiens_hsa045102.92862206
8Dilated cardiomyopathy_Homo sapiens_hsa054142.66393359
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.61183719
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.56135873
11Type I diabetes mellitus_Homo sapiens_hsa049402.55673517
12Primary immunodeficiency_Homo sapiens_hsa053402.49299248
13Protein digestion and absorption_Homo sapiens_hsa049742.31105344
14B cell receptor signaling pathway_Homo sapiens_hsa046622.22199909
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.19898373
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.08963653
17Proteoglycans in cancer_Homo sapiens_hsa052052.06393637
18Amoebiasis_Homo sapiens_hsa051461.99720848
19Small cell lung cancer_Homo sapiens_hsa052221.99220347
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.95805017
21Viral myocarditis_Homo sapiens_hsa054161.95725396
22Adherens junction_Homo sapiens_hsa045201.85794308
23Chronic myeloid leukemia_Homo sapiens_hsa052201.77227222
24Antigen processing and presentation_Homo sapiens_hsa046121.75196663
25Staphylococcus aureus infection_Homo sapiens_hsa051501.71806634
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.70496290
27Basal cell carcinoma_Homo sapiens_hsa052171.68875454
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66991747
29Systemic lupus erythematosus_Homo sapiens_hsa053221.64516099
30Bladder cancer_Homo sapiens_hsa052191.62315235
31Herpes simplex infection_Homo sapiens_hsa051681.53805514
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50654556
33Hippo signaling pathway_Homo sapiens_hsa043901.50395715
34MicroRNAs in cancer_Homo sapiens_hsa052061.48014920
35Notch signaling pathway_Homo sapiens_hsa043301.44681951
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43630423
37Influenza A_Homo sapiens_hsa051641.41814018
38Insulin resistance_Homo sapiens_hsa049311.34688792
39Lysine degradation_Homo sapiens_hsa003101.34540542
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.32389176
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30232077
42Toxoplasmosis_Homo sapiens_hsa051451.28075150
43Hedgehog signaling pathway_Homo sapiens_hsa043401.27776880
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27668941
45TGF-beta signaling pathway_Homo sapiens_hsa043501.27114386
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.23510096
47Epstein-Barr virus infection_Homo sapiens_hsa051691.16478504
48Fatty acid degradation_Homo sapiens_hsa000711.16354235
49Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16072548
50HTLV-I infection_Homo sapiens_hsa051661.13891414
51Rheumatoid arthritis_Homo sapiens_hsa053231.11106294
52Measles_Homo sapiens_hsa051621.10888545
53Platelet activation_Homo sapiens_hsa046111.10332724
54Prostate cancer_Homo sapiens_hsa052151.08205839
55Pancreatic cancer_Homo sapiens_hsa052121.06876662
56Central carbon metabolism in cancer_Homo sapiens_hsa052301.04443040
57Adipocytokine signaling pathway_Homo sapiens_hsa049201.03081150
58Pathways in cancer_Homo sapiens_hsa052001.03003756
59Renal cell carcinoma_Homo sapiens_hsa052111.01965639
60Malaria_Homo sapiens_hsa051441.00851975
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00657472
62Hepatitis C_Homo sapiens_hsa051600.99850345
63Acute myeloid leukemia_Homo sapiens_hsa052210.98798458
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95669501
65Glioma_Homo sapiens_hsa052140.94699979
66HIF-1 signaling pathway_Homo sapiens_hsa040660.94435221
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93743470
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92679222
69Tuberculosis_Homo sapiens_hsa051520.92575830
70Tight junction_Homo sapiens_hsa045300.92470392
71PPAR signaling pathway_Homo sapiens_hsa033200.92380368
72TNF signaling pathway_Homo sapiens_hsa046680.92117811
73VEGF signaling pathway_Homo sapiens_hsa043700.91643446
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90373317
75Rap1 signaling pathway_Homo sapiens_hsa040150.89413057
76Melanoma_Homo sapiens_hsa052180.89292672
77Hematopoietic cell lineage_Homo sapiens_hsa046400.88900096
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87512965
79Phagosome_Homo sapiens_hsa041450.87502952
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87043703
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85863689
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85755051
83AMPK signaling pathway_Homo sapiens_hsa041520.84862371
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83132638
85Endometrial cancer_Homo sapiens_hsa052130.81850471
86Other glycan degradation_Homo sapiens_hsa005110.81444607
87Insulin signaling pathway_Homo sapiens_hsa049100.81424078
88mTOR signaling pathway_Homo sapiens_hsa041500.80391397
89Osteoclast differentiation_Homo sapiens_hsa043800.77463102
90Estrogen signaling pathway_Homo sapiens_hsa049150.76545603
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76248513
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74599085
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.74469645
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.74358681
95Fatty acid metabolism_Homo sapiens_hsa012120.73718383
96Prolactin signaling pathway_Homo sapiens_hsa049170.72774744
97Colorectal cancer_Homo sapiens_hsa052100.72617745
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71364637
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70546188
100Hepatitis B_Homo sapiens_hsa051610.70012965
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.69637023
102T cell receptor signaling pathway_Homo sapiens_hsa046600.69595016
103Non-small cell lung cancer_Homo sapiens_hsa052230.69219197
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68114095
105Sulfur relay system_Homo sapiens_hsa041220.66600840
106p53 signaling pathway_Homo sapiens_hsa041150.65784778
107Chemokine signaling pathway_Homo sapiens_hsa040620.65290249
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64689832
109Apoptosis_Homo sapiens_hsa042100.64262016
110Shigellosis_Homo sapiens_hsa051310.62902617
111FoxO signaling pathway_Homo sapiens_hsa040680.62303641
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61052569
113Wnt signaling pathway_Homo sapiens_hsa043100.61051310
114Axon guidance_Homo sapiens_hsa043600.58720831
115Viral carcinogenesis_Homo sapiens_hsa052030.57205334
116Renin-angiotensin system_Homo sapiens_hsa046140.55525653
117Melanogenesis_Homo sapiens_hsa049160.55018900
118Carbon metabolism_Homo sapiens_hsa012000.53662662
119Thyroid cancer_Homo sapiens_hsa052160.53436689
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53145749
121Glucagon signaling pathway_Homo sapiens_hsa049220.51665662
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51255660
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.50694400
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.49851177
125Cardiac muscle contraction_Homo sapiens_hsa042600.48082923
126Alcoholism_Homo sapiens_hsa050340.47528283
127Leishmaniasis_Homo sapiens_hsa051400.47304147
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45814280
129Propanoate metabolism_Homo sapiens_hsa006400.44460989
130Endocytosis_Homo sapiens_hsa041440.44275205
131Ovarian steroidogenesis_Homo sapiens_hsa049130.44122683
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43832725
133Gap junction_Homo sapiens_hsa045400.42859532
134African trypanosomiasis_Homo sapiens_hsa051430.42339352
135MAPK signaling pathway_Homo sapiens_hsa040100.42219011
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40963719
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40755150
138Pertussis_Homo sapiens_hsa051330.40752889
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40450832
140Tryptophan metabolism_Homo sapiens_hsa003800.38950437
141GnRH signaling pathway_Homo sapiens_hsa049120.36383666
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35819821
143Cocaine addiction_Homo sapiens_hsa050300.33826063
144Prion diseases_Homo sapiens_hsa050200.28244330
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27421982
146Fructose and mannose metabolism_Homo sapiens_hsa000510.26707509

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