HHEX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.55817667
2negative regulation of erythrocyte differentiation (GO:0045647)5.47452087
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.81331981
4L-phenylalanine catabolic process (GO:0006559)4.81331981
5aromatic amino acid family catabolic process (GO:0009074)4.75273302
6indole-containing compound catabolic process (GO:0042436)4.75122676
7indolalkylamine catabolic process (GO:0046218)4.75122676
8tryptophan catabolic process (GO:0006569)4.75122676
9L-phenylalanine metabolic process (GO:0006558)4.65035086
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.65035086
11tryptophan metabolic process (GO:0006568)4.43080709
12kynurenine metabolic process (GO:0070189)4.34279115
13regulation of B cell receptor signaling pathway (GO:0050855)4.29429095
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.14993479
15B cell receptor signaling pathway (GO:0050853)4.14842974
16regulation of B cell differentiation (GO:0045577)4.06044061
17bile acid biosynthetic process (GO:0006699)4.05114795
18regulation of mast cell degranulation (GO:0043304)4.04324861
19response to peptidoglycan (GO:0032494)4.04308629
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.01362395
21negative regulation of fibrinolysis (GO:0051918)3.95306054
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.92079462
23detection of other organism (GO:0098543)3.84729437
24positive regulation of granulocyte differentiation (GO:0030854)3.82539992
25detection of bacterium (GO:0016045)3.80504584
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.76904583
27megakaryocyte development (GO:0035855)3.75801887
28regulation of mast cell activation involved in immune response (GO:0033006)3.74266418
29regulation of gamma-delta T cell differentiation (GO:0045586)3.72812162
30regulation of fibrinolysis (GO:0051917)3.71611198
31regulation of myeloid leukocyte mediated immunity (GO:0002886)3.69624218
32urea metabolic process (GO:0019627)3.69044295
33urea cycle (GO:0000050)3.69044295
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.62269162
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.62269162
36mucosal-associated lymphoid tissue development (GO:0048537)3.61566895
37Peyers patch development (GO:0048541)3.61566895
38glyoxylate metabolic process (GO:0046487)3.60586802
39complement activation, alternative pathway (GO:0006957)3.59937716
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.59633023
41positive regulation by organism of defense response of other organism involved in symbiotic interact3.59633023
42modulation by symbiont of host immune response (GO:0052553)3.59633023
43positive regulation by symbiont of host defense response (GO:0052509)3.59633023
44modulation by symbiont of host defense response (GO:0052031)3.59633023
45modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.59633023
46alpha-linolenic acid metabolic process (GO:0036109)3.57110488
47regulation of gamma-delta T cell activation (GO:0046643)3.55944031
48peptidyl-glutamic acid carboxylation (GO:0017187)3.55616092
49protein carboxylation (GO:0018214)3.55616092
50NAD biosynthetic process (GO:0009435)3.52534992
51high-density lipoprotein particle remodeling (GO:0034375)3.51784944
52B cell mediated immunity (GO:0019724)3.50073932
53blood coagulation, intrinsic pathway (GO:0007597)3.48023410
54regulation of protein activation cascade (GO:2000257)3.47244404
55sulfur amino acid catabolic process (GO:0000098)3.43765243
56nitrogen cycle metabolic process (GO:0071941)3.40413519
57ribosomal small subunit assembly (GO:0000028)3.40315389
58regulation of leukocyte degranulation (GO:0043300)3.39135900
59amine catabolic process (GO:0009310)3.38765076
60cellular biogenic amine catabolic process (GO:0042402)3.38765076
61neutrophil activation (GO:0042119)3.37050442
62aromatic amino acid family metabolic process (GO:0009072)3.36210687
63regulation of cholesterol esterification (GO:0010872)3.35836123
64antigen processing and presentation of endogenous antigen (GO:0019883)3.30033895
65bile acid metabolic process (GO:0008206)3.29898720
66pyridine nucleotide biosynthetic process (GO:0019363)3.28500559
67nicotinamide nucleotide biosynthetic process (GO:0019359)3.28500559
68cysteine metabolic process (GO:0006534)3.28419495
69positive regulation of B cell differentiation (GO:0045579)3.26241195
70killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.25696904
71disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.25696904
72positive regulation of mast cell degranulation (GO:0043306)3.24827765
73positive regulation of mast cell activation involved in immune response (GO:0033008)3.24827765
74regulation of complement activation (GO:0030449)3.24692038
75regulation of mast cell activation (GO:0033003)3.24625134
76indolalkylamine metabolic process (GO:0006586)3.23618491
77leukocyte degranulation (GO:0043299)3.23350962
78amino-acid betaine metabolic process (GO:0006577)3.19940872
79phospholipid efflux (GO:0033700)3.18704831
80regulation of triglyceride catabolic process (GO:0010896)3.17261861
81imidazole-containing compound metabolic process (GO:0052803)3.15593378
82mature B cell differentiation involved in immune response (GO:0002313)3.14663263
83detection of external biotic stimulus (GO:0098581)3.14004226
84positive thymic T cell selection (GO:0045059)3.13351109
85positive regulation of mast cell activation (GO:0033005)3.11966980
86negative regulation of cell killing (GO:0031342)3.11778991
87negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.11778991
88regulation of erythrocyte differentiation (GO:0045646)3.11731921
89glycine metabolic process (GO:0006544)3.11160133
90plasma lipoprotein particle remodeling (GO:0034369)3.08967449
91protein-lipid complex remodeling (GO:0034368)3.08967449
92macromolecular complex remodeling (GO:0034367)3.08967449
93cellular extravasation (GO:0045123)3.06816129
94reverse cholesterol transport (GO:0043691)3.05687661
95endothelium development (GO:0003158)3.04121130
96ethanol oxidation (GO:0006069)3.03417643
97myeloid cell activation involved in immune response (GO:0002275)3.03319592
98serine family amino acid catabolic process (GO:0009071)3.02845759
99positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.00065520
100positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.99740896
101antigen processing and presentation via MHC class Ib (GO:0002475)2.98872349
102regulation of granulocyte differentiation (GO:0030852)2.98826917
103regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.98471147
104leukocyte migration involved in inflammatory response (GO:0002523)2.95294732
105bile acid and bile salt transport (GO:0015721)2.95259696
106response to muramyl dipeptide (GO:0032495)2.95230060
107low-density lipoprotein particle remodeling (GO:0034374)2.94793357
108DNA deamination (GO:0045006)2.93143997
109protein activation cascade (GO:0072376)2.90559051
110granulocyte activation (GO:0036230)2.90164065
111benzene-containing compound metabolic process (GO:0042537)2.90154966
112complement activation, classical pathway (GO:0006958)2.89749551
113negative regulation of cholesterol transport (GO:0032375)2.87681993
114negative regulation of sterol transport (GO:0032372)2.87681993
115response to protozoan (GO:0001562)2.87136704
116alpha-amino acid catabolic process (GO:1901606)2.87004862
117urate metabolic process (GO:0046415)2.86700893
118platelet dense granule organization (GO:0060155)2.86373048
119Arp2/3 complex-mediated actin nucleation (GO:0034314)2.85500329
120regulation of hypersensitivity (GO:0002883)2.83694786
121tyrosine metabolic process (GO:0006570)2.83422209
122cofactor catabolic process (GO:0051187)2.81918289
123definitive hemopoiesis (GO:0060216)2.81533302
124response to host immune response (GO:0052572)2.80904322
125response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.80904322
126opsonization (GO:0008228)2.79719413
127leukocyte aggregation (GO:0070486)2.79430733
128serine family amino acid biosynthetic process (GO:0009070)2.78218522
129pinocytosis (GO:0006907)2.77605723
130response to interferon-beta (GO:0035456)2.77323138
131negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.77290596
132complement activation (GO:0006956)2.76802969
133regulation of humoral immune response (GO:0002920)2.76605592
134valine metabolic process (GO:0006573)2.74952109
135coenzyme catabolic process (GO:0009109)2.74739184
136cellular response to thyroid hormone stimulus (GO:0097067)2.74659107
137aldehyde catabolic process (GO:0046185)2.74355356
138triglyceride homeostasis (GO:0070328)2.73859193
139acylglycerol homeostasis (GO:0055090)2.73859193
140mature B cell differentiation (GO:0002335)2.71839469
141detection of biotic stimulus (GO:0009595)2.71619114
142disruption of cells of other organism (GO:0044364)2.71037431
143killing of cells of other organism (GO:0031640)2.71037431
144regulation of regulated secretory pathway (GO:1903305)2.70343336
145serine family amino acid metabolic process (GO:0009069)2.70109228
146regulation of B cell apoptotic process (GO:0002902)2.69980109
147positive regulation of interleukin-17 production (GO:0032740)2.66647387
148myeloid cell development (GO:0061515)2.66109164
149positive regulation of lipoprotein lipase activity (GO:0051006)2.65663328
150positive regulation of triglyceride lipase activity (GO:0061365)2.65663328
151plasma lipoprotein particle assembly (GO:0034377)2.65470463
152macrophage activation involved in immune response (GO:0002281)2.65459178
153arginine metabolic process (GO:0006525)2.64616452
154negative regulation of interleukin-12 production (GO:0032695)2.63892575
155regulation of antigen processing and presentation (GO:0002577)2.63049749
156thrombin receptor signaling pathway (GO:0070493)2.61991025
157regulation of interleukin-17 production (GO:0032660)2.60684176
158fibrinolysis (GO:0042730)2.59807457
159homocysteine metabolic process (GO:0050667)2.59570167
160positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.57883402
161primary alcohol catabolic process (GO:0034310)2.57229626
162negative regulation of granulocyte differentiation (GO:0030853)2.57097188
163response to host (GO:0075136)2.55841402
164response to host defenses (GO:0052200)2.55841402
165response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.55841402
166positive regulation of gamma-delta T cell activation (GO:0046645)2.55817779
167germinal center formation (GO:0002467)2.55405761
168pyridine-containing compound biosynthetic process (GO:0072525)2.55345417
169defense response to protozoan (GO:0042832)2.55321515
170lysine metabolic process (GO:0006553)2.55238440
171lysine catabolic process (GO:0006554)2.55238440
172acute-phase response (GO:0006953)2.55197699
173granulocyte differentiation (GO:0030851)2.54870011
174mast cell activation (GO:0045576)2.54746775
175positive regulation of B cell activation (GO:0050871)2.54352489
176immunoglobulin mediated immune response (GO:0016064)2.53965617
177lipopolysaccharide-mediated signaling pathway (GO:0031663)2.53757445
178negative regulation of T-helper cell differentiation (GO:0045623)2.50473888
179negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.50473888
180histamine secretion (GO:0001821)2.48826314
181deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.47695784
182regulation of superoxide anion generation (GO:0032928)2.47451229
183detection of molecule of bacterial origin (GO:0032490)2.46593334
184negative regulation of lymphocyte mediated immunity (GO:0002707)2.43942538
185positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.42846336
186regulation of dendritic cell antigen processing and presentation (GO:0002604)2.42759642
187response to thyroid hormone (GO:0097066)2.41450345
188erythrocyte maturation (GO:0043249)2.40505322
189positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.40369576
190negative regulation of B cell apoptotic process (GO:0002903)2.39205179
191macrophage activation (GO:0042116)2.38174754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.95859262
2EGR1_23403033_ChIP-Seq_LIVER_Mouse4.13951635
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.08840965
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.81492024
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.66950505
6* SCL_19346495_ChIP-Seq_HPC-7_Human3.47995039
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.19604071
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.93088669
9* LXR_22158963_ChIP-Seq_LIVER_Mouse2.81066327
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78021756
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.74479165
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.65309654
13GATA1_22025678_ChIP-Seq_K562_Human2.64722669
14* EGR1_19374776_ChIP-ChIP_THP-1_Human2.62360351
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55650050
16* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.54335404
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.46314836
18E2F7_22180533_ChIP-Seq_HELA_Human2.44037274
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.35734261
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28814842
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.25589888
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.25501433
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21241879
24SPI1_23127762_ChIP-Seq_K562_Human2.20571374
25* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.18806610
26BP1_19119308_ChIP-ChIP_Hs578T_Human2.09859642
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.05517168
28* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98541610
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95588732
30* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90953389
31* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90926451
32SPI1_23547873_ChIP-Seq_NB4_Human1.90722200
33* IRF8_27001747_Chip-Seq_BMDM_Mouse1.86155437
34* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.83537887
35* GATA1_19941826_ChIP-Seq_K562_Human1.81972005
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69170210
37* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.66936617
38VDR_21846776_ChIP-Seq_THP-1_Human1.65660680
39* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.64057590
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.62825104
41* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60556724
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58945569
43* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58933244
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57647696
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57604527
46NCOR1_26117541_ChIP-Seq_K562_Human1.56282981
47MYC_22102868_ChIP-Seq_BL_Human1.55687666
48GATA1_22383799_ChIP-Seq_G1ME_Mouse1.54986922
49GATA3_27048872_Chip-Seq_THYMUS_Human1.53957010
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53660027
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53502560
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.52006685
53* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51725433
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49281027
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49191235
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.48906277
57* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.48021923
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.41993715
59* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36652416
60MAF_26560356_Chip-Seq_TH1_Human1.35610586
61* MYB_26560356_Chip-Seq_TH1_Human1.33989761
62MYB_26560356_Chip-Seq_TH2_Human1.33948931
63* GATA2_21666600_ChIP-Seq_HMVEC_Human1.33885848
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.32664600
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32210602
66* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30732188
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30483679
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30123826
69* GATA2_19941826_ChIP-Seq_K562_Human1.29573703
70VDR_24763502_ChIP-Seq_THP-1_Human1.28993226
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27416260
72FOXP3_21729870_ChIP-Seq_TREG_Human1.26559463
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.23862583
74VDR_24787735_ChIP-Seq_THP-1_Human1.21931259
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19534655
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.18642881
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.18063152
78* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17880001
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.17680868
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16408913
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16343076
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15767091
83* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15655626
84EST1_17652178_ChIP-ChIP_JURKAT_Human1.15195463
85VDR_23849224_ChIP-Seq_CD4+_Human1.14432252
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14257318
87RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14122410
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13559108
89* KDM2B_26808549_Chip-Seq_DND41_Human1.13106438
90* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11529757
91STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11288333
92* BCL6_27268052_Chip-Seq_Bcells_Human1.10901626
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10642364
94* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10114180
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10006610
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09423004
97UTX_26944678_Chip-Seq_JUKART_Human1.08918362
98GATA3_26560356_Chip-Seq_TH2_Human1.08498174
99* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07638233
100KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06727344
101* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06347605
102RUNX_20019798_ChIP-Seq_JUKART_Human1.06064240
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05959575
104* SPI1_20517297_ChIP-Seq_HL60_Human1.05578536
105* TCF7_22412390_ChIP-Seq_EML_Mouse1.05050367
106BCOR_27268052_Chip-Seq_Bcells_Human1.03107814
107FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02847920
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00727518
109P300_27268052_Chip-Seq_Bcells_Human0.99202737
110PU_27001747_Chip-Seq_BMDM_Mouse0.98300592
111TFEB_21752829_ChIP-Seq_HELA_Human0.97321410
112E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95348166
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94077279
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93949174
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93710981
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93654793
117E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93494061
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93340142
119CIITA_25753668_ChIP-Seq_RAJI_Human0.91478189
120ETS1_20019798_ChIP-Seq_JURKAT_Human0.90659869
121* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89045728
122CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86531875
123* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85883753
124MYC_19030024_ChIP-ChIP_MESCs_Mouse0.85729188
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84874169
126E2F4_17652178_ChIP-ChIP_JURKAT_Human0.84606131
127* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83887836
128MAF_26560356_Chip-Seq_TH2_Human0.83466257
129* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82651516
130* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81873116
131GABP_19822575_ChIP-Seq_HepG2_Human0.81382386
132* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81195354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.86589293
2MP0005360_urolithiasis4.28977526
3MP0005085_abnormal_gallbladder_physiolo4.02678003
4MP0005365_abnormal_bile_salt3.94162783
5MP0008875_abnormal_xenobiotic_pharmacok3.20901174
6MP0001835_abnormal_antigen_presentation2.91073089
7MP0009840_abnormal_foam_cell2.58602288
8MP0003806_abnormal_nucleotide_metabolis2.54822069
9MP0003252_abnormal_bile_duct2.52720784
10MP0003191_abnormal_cellular_cholesterol2.41239966
11MP0002396_abnormal_hematopoietic_system2.36209177
12MP0009785_altered_susceptibility_to2.30621895
13MP0010329_abnormal_lipoprotein_level2.20175568
14MP0002138_abnormal_hepatobiliary_system2.20026629
15MP0005464_abnormal_platelet_physiology2.17741769
16MP0003724_increased_susceptibility_to2.05621141
17MP0003436_decreased_susceptibility_to2.03648847
18MP0000685_abnormal_immune_system1.92462206
19MP0005083_abnormal_biliary_tract1.92096314
20MP0005025_abnormal_response_to1.85616737
21MP0005671_abnormal_response_to1.85240247
22MP0001545_abnormal_hematopoietic_system1.82332341
23MP0005397_hematopoietic_system_phenotyp1.82332341
24MP0001800_abnormal_humoral_immune1.81633108
25MP0003656_abnormal_erythrocyte_physiolo1.73825251
26MP0002419_abnormal_innate_immunity1.69532646
27MP0000609_abnormal_liver_physiology1.67506487
28MP0001666_abnormal_nutrient_absorption1.66176703
29MP0001764_abnormal_homeostasis1.64231260
30MP0001853_heart_inflammation1.61924785
31MP0008469_abnormal_protein_level1.57933295
32MP0002452_abnormal_antigen_presenting1.56988240
33MP0002723_abnormal_immune_serum1.55810747
34MP0005075_abnormal_melanosome_morpholog1.52739385
35MP0005319_abnormal_enzyme/_coenzyme1.51563329
36MP0002148_abnormal_hypersensitivity_rea1.50671501
37MP0005000_abnormal_immune_tolerance1.50292463
38MP0004808_abnormal_hematopoietic_stem1.49483712
39MP0010368_abnormal_lymphatic_system1.47114864
40MP0001790_abnormal_immune_system1.46264014
41MP0005387_immune_system_phenotype1.46264014
42MP0005332_abnormal_amino_acid1.45796799
43MP0003828_pulmonary_edema1.45115929
44MP0003868_abnormal_feces_composition1.44817801
45MP0009764_decreased_sensitivity_to1.44511782
46MP0005451_abnormal_body_composition1.43404659
47MP0003186_abnormal_redox_activity1.43309548
48MP0009697_abnormal_copulation1.41327723
49MP0002420_abnormal_adaptive_immunity1.41234349
50MP0002166_altered_tumor_susceptibility1.40826451
51MP0001819_abnormal_immune_cell1.40537575
52MP0000689_abnormal_spleen_morphology1.39475894
53MP0000465_gastrointestinal_hemorrhage1.39347187
54* MP0002398_abnormal_bone_marrow1.39042712
55MP0000703_abnormal_thymus_morphology1.35246303
56MP0001845_abnormal_inflammatory_respons1.29379431
57* MP0000716_abnormal_immune_system1.28880349
58MP0005584_abnormal_enzyme/coenzyme_acti1.28729554
59MP0010155_abnormal_intestine_physiology1.27326115
60* MP0000598_abnormal_liver_morphology1.25851877
61MP0002118_abnormal_lipid_homeostasis1.25467490
62MP0009763_increased_sensitivity_to1.22575191
63MP0002722_abnormal_immune_system1.22520215
64* MP0002429_abnormal_blood_cell1.19799215
65MP0003183_abnormal_peptide_metabolism1.19679260
66MP0003195_calcinosis1.19021057
67MP0001851_eye_inflammation1.16420472
68MP0004147_increased_porphyrin_level1.15764657
69MP0004019_abnormal_vitamin_homeostasis1.14563903
70MP0008004_abnormal_stomach_pH1.10713908
71MP0006082_CNS_inflammation1.10596755
72MP0005174_abnormal_tail_pigmentation1.08576070
73MP0003763_abnormal_thymus_physiology1.06449857
74MP0008260_abnormal_autophagy1.06386772
75MP0001873_stomach_inflammation1.04774727
76MP0002405_respiratory_system_inflammati1.03752241
77MP0002132_abnormal_respiratory_system1.03191995
78MP0000858_altered_metastatic_potential0.99170388
79MP0009333_abnormal_splenocyte_physiolog0.99118808
80MP0000490_abnormal_crypts_of0.98784719
81MP0003075_altered_response_to0.97523130
82MP0009643_abnormal_urine_homeostasis0.96694776
83MP0009278_abnormal_bone_marrow0.96272427
84MP0006054_spinal_hemorrhage0.94708811
85MP0009765_abnormal_xenobiotic_induced0.92554824
86MP0002006_tumorigenesis0.91639327
87MP0006036_abnormal_mitochondrial_physio0.91633026
88MP0005058_abnormal_lysosome_morphology0.90741992
89MP0003300_gastrointestinal_ulcer0.88659159
90MP0004883_abnormal_blood_vessel0.87820892
91MP0009379_abnormal_foot_pigmentation0.86465708
92MP0008057_abnormal_DNA_replication0.86056907
93MP0003866_abnormal_defecation0.85289035
94MP0003693_abnormal_embryo_hatching0.85192666
95MP0004782_abnormal_surfactant_physiolog0.84282594
96MP0002009_preneoplasia0.84086557
97* MP0000681_abnormal_thyroid_gland0.84069720
98MP0000015_abnormal_ear_pigmentation0.84010144
99MP0005220_abnormal_exocrine_pancreas0.83995056
100MP0009642_abnormal_blood_homeostasis0.82966230
101MP0004947_skin_inflammation0.81317075
102MP0001533_abnormal_skeleton_physiology0.79108829
103MP0003172_abnormal_lysosome_physiology0.78633363
104MP0003011_delayed_dark_adaptation0.77060466
105MP0002019_abnormal_tumor_incidence0.76782066
106* MP0003943_abnormal_hepatobiliary_system0.76073986
107MP0005636_abnormal_mineral_homeostasis0.75319943
108MP0000249_abnormal_blood_vessel0.74370073
109MP0005164_abnormal_response_to0.74031830
110MP0001663_abnormal_digestive_system0.72671989
111MP0003638_abnormal_response/metabolism_0.72061705
112MP0008873_increased_physiological_sensi0.71486943
113MP0008007_abnormal_cellular_replicative0.71136358
114MP0000343_altered_response_to0.69831164
115MP0005647_abnormal_sex_gland0.69341092
116MP0002095_abnormal_skin_pigmentation0.68869974
117MP0002998_abnormal_bone_remodeling0.68380901
118MP0000678_abnormal_parathyroid_gland0.66962986
119MP0003303_peritoneal_inflammation0.65903385
120MP0005166_decreased_susceptibility_to0.64677259
121MP0005376_homeostasis/metabolism_phenot0.64138740

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.39995935
2Prolonged partial thromboplastin time (HP:0003645)4.81100203
3Intrahepatic cholestasis (HP:0001406)4.38014715
4Deep venous thrombosis (HP:0002625)4.37468093
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.30242438
6Joint hemorrhage (HP:0005261)4.10434506
7Chronic obstructive pulmonary disease (HP:0006510)4.05102090
8Obstructive lung disease (HP:0006536)4.05102090
9Hypobetalipoproteinemia (HP:0003563)3.83281862
10Complement deficiency (HP:0004431)3.74820344
11Recurrent fungal infections (HP:0002841)3.62914555
12Xanthomatosis (HP:0000991)3.59947912
13Eczematoid dermatitis (HP:0000976)3.56474566
14Hyperlipoproteinemia (HP:0010980)3.53038362
15Abnormality of the common coagulation pathway (HP:0010990)3.42941160
16Thrombocytosis (HP:0001894)3.41698565
17Abnormality of pyrimidine metabolism (HP:0004353)3.41143207
18Stomatitis (HP:0010280)3.41132459
19Acute lymphatic leukemia (HP:0006721)3.39980152
20Abnormality of B cell number (HP:0010975)3.38916678
21Gingival bleeding (HP:0000225)3.26707990
22Epistaxis (HP:0000421)3.22778120
23Prolonged bleeding time (HP:0003010)3.14672194
24Reduced antithrombin III activity (HP:0001976)3.11562776
25Recurrent gram-negative bacterial infections (HP:0005420)3.11064777
26Gastrointestinal infarctions (HP:0005244)3.10877977
27Abnormality of complement system (HP:0005339)3.07105490
28Orchitis (HP:0100796)3.04504000
29B lymphocytopenia (HP:0010976)3.02109518
30Recurrent bacterial skin infections (HP:0005406)3.01146795
31Hyperbilirubinemia (HP:0002904)3.00440786
32Elevated erythrocyte sedimentation rate (HP:0003565)2.98657416
33Abnormality of the heme biosynthetic pathway (HP:0010472)2.97110580
34Impaired platelet aggregation (HP:0003540)2.92731106
35Abnormal platelet function (HP:0011869)2.92731106
36Granulocytopenia (HP:0001913)2.92401598
37Hyperammonemia (HP:0001987)2.92230183
38Abnormality of the intrinsic pathway (HP:0010989)2.91376140
39Mediastinal lymphadenopathy (HP:0100721)2.90802854
40Petechiae (HP:0000967)2.89966057
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.87215567
42Recurrent abscess formation (HP:0002722)2.81186068
43IgM deficiency (HP:0002850)2.78354653
44Chronic mucocutaneous candidiasis (HP:0002728)2.77982438
45Recurrent cutaneous fungal infections (HP:0011370)2.77982438
46Myositis (HP:0100614)2.77545312
47Fat malabsorption (HP:0002630)2.77354741
48Systemic lupus erythematosus (HP:0002725)2.76588587
49Retrobulbar optic neuritis (HP:0100654)2.74238090
50Optic neuritis (HP:0100653)2.74238090
51Hypercholesterolemia (HP:0003124)2.74079351
52Acute hepatic failure (HP:0006554)2.70503967
53Vasculitis (HP:0002633)2.68699954
54Hypochromic anemia (HP:0001931)2.65392292
55Episodic fever (HP:0001954)2.63620969
56Spontaneous hematomas (HP:0007420)2.63331216
57Hypochromic microcytic anemia (HP:0004840)2.62776598
58Hypoglycemic coma (HP:0001325)2.61806668
59Abnormality of methionine metabolism (HP:0010901)2.61742380
60Urticaria (HP:0001025)2.61354627
61Increased IgE level (HP:0003212)2.59213413
62Acute myeloid leukemia (HP:0004808)2.57285341
63Arterial thrombosis (HP:0004420)2.55762876
64Chest pain (HP:0100749)2.55088597
65Hypolipoproteinemia (HP:0010981)2.54761299
66Microcytic anemia (HP:0001935)2.54679928
67Abnormality of fatty-acid metabolism (HP:0004359)2.54557032
68Aplastic anemia (HP:0001915)2.54408579
69Autoimmune hemolytic anemia (HP:0001890)2.53974073
70Abnormal hemoglobin (HP:0011902)2.49735603
71Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.49558153
72Abnormality of the prostate (HP:0008775)2.48239412
73Abnormality of sulfur amino acid metabolism (HP:0004339)2.47499639
74Leukocytosis (HP:0001974)2.46215313
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.46099741
76Menorrhagia (HP:0000132)2.45981869
77Fatigue (HP:0012378)2.45388098
78Ketosis (HP:0001946)2.44622631
79Conjugated hyperbilirubinemia (HP:0002908)2.44465841
80Chronic otitis media (HP:0000389)2.43958781
81Steatorrhea (HP:0002570)2.42256592
82Thrombophlebitis (HP:0004418)2.41998495
83Glomerulonephritis (HP:0000099)2.41809500
84Abnormality of the peritoneum (HP:0002585)2.41777811
85Osteomyelitis (HP:0002754)2.39937401
86Delayed CNS myelination (HP:0002188)2.38562166
87Polygenic inheritance (HP:0010982)2.37660288
88Spontaneous abortion (HP:0005268)2.37074125
89Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35839091
90Aplasia/Hypoplasia of the thymus (HP:0010515)2.35764951
91Abnormality of T cell physiology (HP:0011840)2.35710261
92Epidermoid cyst (HP:0200040)2.34985228
93Recurrent skin infections (HP:0001581)2.34787907
94Hypertensive crisis (HP:0100735)2.34433167
95Abnormality of T cells (HP:0002843)2.33519706
96Viral hepatitis (HP:0006562)2.31187217
97Seborrheic dermatitis (HP:0001051)2.29801653
98Generalized aminoaciduria (HP:0002909)2.29314927
99Autoimmune thrombocytopenia (HP:0001973)2.28266640
100Abnormality of glutamine family amino acid metabolism (HP:0010902)2.27455756
101Purpura (HP:0000979)2.25155669
102Abnormality of nucleobase metabolism (HP:0010932)2.23384475
103Meningitis (HP:0001287)2.22306149
104Abnormality of iron homeostasis (HP:0011031)2.22071509
105Agammaglobulinemia (HP:0004432)2.20278052
106Hyperglycinemia (HP:0002154)2.19866942
107Abnormal number of erythroid precursors (HP:0012131)2.19136092
108Increased serum ferritin (HP:0003281)2.17761555
109Increased IgM level (HP:0003496)2.16110303
110Inflammation of the large intestine (HP:0002037)2.14760465
111Colitis (HP:0002583)2.14593702
112Skin rash (HP:0000988)2.12934079
113Recurrent viral infections (HP:0004429)2.12775713
114Vacuolated lymphocytes (HP:0001922)2.11791199
115Pulmonary embolism (HP:0002204)2.11682469
116Peritonitis (HP:0002586)2.10503853
117Acanthocytosis (HP:0001927)2.10346107
118Keratoconjunctivitis sicca (HP:0001097)2.09953045
119Abnormality of cells of the erythroid lineage (HP:0012130)2.09707316
120Abnormal delayed hypersensitivity skin test (HP:0002963)2.08779295
121Pallor (HP:0000980)2.07688064
122Gastrointestinal inflammation (HP:0004386)2.07475078
123Panhypogammaglobulinemia (HP:0003139)2.04932641
124Eosinophilia (HP:0001880)2.04429639
125Encephalitis (HP:0002383)2.04392835
126Myocardial infarction (HP:0001658)2.04142848
127Pulmonary infiltrates (HP:0002113)2.03938293
128Type I transferrin isoform profile (HP:0003642)2.03921664
129Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03529813
130Dicarboxylic aciduria (HP:0003215)2.03529813
131Hepatosplenomegaly (HP:0001433)2.02948628
132Severe combined immunodeficiency (HP:0004430)1.98850332
133Hypoalphalipoproteinemia (HP:0003233)1.97701655
134Elevated hepatic transaminases (HP:0002910)1.97316273
135Periodontitis (HP:0000704)1.97257406
136Abnormality of transition element cation homeostasis (HP:0011030)1.95033244
137Hypoplasia of the thymus (HP:0000778)1.94777308
138Esophageal varix (HP:0002040)1.94635473
139Increased mean platelet volume (HP:0011877)1.93664969
140Abnormality of serum amino acid levels (HP:0003112)1.92603399
141Gingivitis (HP:0000230)1.91841450
142Abnormality of macrophages (HP:0004311)1.90743898
143Cellulitis (HP:0100658)1.90741546
144Polycythemia (HP:0001901)1.90697093
145Poikilocytosis (HP:0004447)1.90318940
146Hyperglycinuria (HP:0003108)1.89661651
147Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89260863
148Sepsis (HP:0100806)1.88833575
149Reticulocytopenia (HP:0001896)1.88607326
150Abnormality of serine family amino acid metabolism (HP:0010894)1.88119257
151Abnormality of glycine metabolism (HP:0010895)1.88119257
152Abnormal platelet volume (HP:0011876)1.87898890
153Pustule (HP:0200039)1.87077379
154Amyloidosis (HP:0011034)1.86982848

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.32533147
2TAOK33.05440761
3KIT2.84229946
4FLT32.79547007
5ERN12.69074526
6BCKDK2.52787759
7STK162.41013257
8BTK2.29526778
9TEC2.24554592
10BLK2.21990694
11IRAK42.10445262
12TGFBR22.03430166
13CSF1R2.03209528
14TIE12.02605429
15TBK12.00678873
16TYK22.00526051
17MAP2K31.95005946
18BMPR21.93791325
19KDR1.86385323
20IRAK31.73275191
21TGFBR11.72961174
22ACVR1B1.71127570
23PRPF4B1.68087097
24PIM21.59097787
25MAP3K141.58503356
26ZAP701.56682478
27FGFR41.54140801
28IKBKE1.54023779
29NME21.50602996
30JAK31.41871596
31IKBKB1.33638545
32EEF2K1.32655536
33BRSK21.30018384
34SYK1.28697763
35TXK1.22055314
36MATK1.21455792
37WEE11.18857907
38MAPK111.16959760
39MAP3K131.16950968
40PIK3CG1.11952756
41LYN1.09795835
42TESK21.03488466
43DYRK31.02462160
44PIM11.02416277
45TRPM71.01572517
46PKN21.00726041
47RPS6KA40.99736156
48MAP3K10.99662882
49CDK120.91562507
50MAP3K60.90145925
51MAP2K60.89553184
52NEK90.86677516
53FES0.85849496
54LRRK20.84379965
55MUSK0.84078318
56MAPK40.83545363
57NLK0.82042938
58STK100.81879598
59SCYL20.81132132
60MAP3K70.81106219
61GRK60.80495993
62NUAK10.79133081
63RPS6KB20.76808321
64VRK10.76241324
65CDK70.75954342
66MAPK150.74402353
67LCK0.73074139
68MAP3K110.72289290
69TNIK0.72135813
70JAK10.72121592
71ADRBK20.72058533
72HCK0.71687788
73MAPKAPK30.71246445
74RAF10.70541468
75ITK0.70526279
76PRKCQ0.70406190
77SMG10.70360108
78TAOK20.70270990
79JAK20.69765110
80CSK0.69341261
81IRAK10.69205184
82MAP3K120.68506398
83HIPK20.67336682
84CHUK0.65338229
85IRAK20.65252783
86PDK10.65186712
87NEK20.63321294
88CDK40.63094024
89PDPK10.62740510
90SIK10.61807488
91MARK30.61665428
92INSRR0.60776639
93EIF2AK30.60691524
94CDK80.59487875
95VRK20.58347790
96PRKG20.57923353
97STK40.56996249
98ABL20.54783736
99MAP3K50.54213875
100CDK90.53965642
101RPS6KL10.53272170
102RPS6KC10.53272170
103FGFR30.53183993
104RET0.53119086
105CDK60.52823236
106MAP3K100.52396434
107GRK10.52139398
108RIPK40.51905284
109DAPK10.50226096
110CLK10.50152225
111PRKAA20.50148579
112EIF2AK10.49353269
113CDK190.49039730
114MAPK70.47684132
115BUB10.47377988
116DYRK1B0.45608347
117CAMKK20.45024034
118DAPK20.44943019
119PASK0.44253813
120PRKD20.43823813
121MAP2K20.43579302
122MKNK10.43194669
123TNK20.42267560
124RPS6KA60.42247776
125MAPK30.41645278
126MAP3K30.40801070
127PAK40.40747561
128ATR0.40019915
129MAPK120.37866028
130MAPKAPK50.36417260
131ABL10.35783120
132FGR0.35051269
133MAPKAPK20.33841027
134KSR20.32972145
135PTK60.32439346
136MAP4K20.31878683
137MAP2K40.30006012
138MAP3K20.29131164

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.02245207
2Asthma_Homo sapiens_hsa053102.98969828
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.96571807
4Allograft rejection_Homo sapiens_hsa053302.86755945
5Autoimmune thyroid disease_Homo sapiens_hsa053202.75393553
6Complement and coagulation cascades_Homo sapiens_hsa046102.65189752
7Graft-versus-host disease_Homo sapiens_hsa053322.52082660
8Caffeine metabolism_Homo sapiens_hsa002322.38008641
9Staphylococcus aureus infection_Homo sapiens_hsa051502.34251700
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.33681560
11Arginine biosynthesis_Homo sapiens_hsa002202.18038737
12Tryptophan metabolism_Homo sapiens_hsa003802.16602714
13Nitrogen metabolism_Homo sapiens_hsa009102.12828965
14Type I diabetes mellitus_Homo sapiens_hsa049402.09444110
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.06118929
16Folate biosynthesis_Homo sapiens_hsa007901.99025560
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.98336827
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.97456952
19Peroxisome_Homo sapiens_hsa041461.97139646
20Platelet activation_Homo sapiens_hsa046111.94521947
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.94011708
22Fatty acid degradation_Homo sapiens_hsa000711.88726598
23Tuberculosis_Homo sapiens_hsa051521.74264181
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.71659678
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69071480
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.69058901
27Histidine metabolism_Homo sapiens_hsa003401.67844947
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.64333379
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63617808
30Chemical carcinogenesis_Homo sapiens_hsa052041.61756924
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59351860
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54631738
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52973016
34DNA replication_Homo sapiens_hsa030301.50961532
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49601517
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49568728
37African trypanosomiasis_Homo sapiens_hsa051431.49553422
38Selenocompound metabolism_Homo sapiens_hsa004501.47952360
39Toxoplasmosis_Homo sapiens_hsa051451.43749356
40Sulfur relay system_Homo sapiens_hsa041221.42533974
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41579052
42beta-Alanine metabolism_Homo sapiens_hsa004101.41464875
43Retinol metabolism_Homo sapiens_hsa008301.40740288
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34816069
45Ribosome_Homo sapiens_hsa030101.33335761
46One carbon pool by folate_Homo sapiens_hsa006701.29649990
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28686417
48ABC transporters_Homo sapiens_hsa020101.28041455
49PPAR signaling pathway_Homo sapiens_hsa033201.23486971
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22455340
51Malaria_Homo sapiens_hsa051441.19316486
52Pentose phosphate pathway_Homo sapiens_hsa000301.16355251
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14933335
54Primary immunodeficiency_Homo sapiens_hsa053401.12738956
55Viral myocarditis_Homo sapiens_hsa054161.11656880
56Propanoate metabolism_Homo sapiens_hsa006401.11213931
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.10630065
58Starch and sucrose metabolism_Homo sapiens_hsa005001.09445558
59Non-small cell lung cancer_Homo sapiens_hsa052231.05722253
60Base excision repair_Homo sapiens_hsa034101.03722593
61Rheumatoid arthritis_Homo sapiens_hsa053231.02235632
62Fatty acid metabolism_Homo sapiens_hsa012120.99837779
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98283701
64Chronic myeloid leukemia_Homo sapiens_hsa052200.97016678
65Mismatch repair_Homo sapiens_hsa034300.93159864
66Pancreatic cancer_Homo sapiens_hsa052120.92322034
67Pyrimidine metabolism_Homo sapiens_hsa002400.90897409
68* Maturity onset diabetes of the young_Homo sapiens_hsa049500.89853542
69Fatty acid elongation_Homo sapiens_hsa000620.89495316
70Biosynthesis of amino acids_Homo sapiens_hsa012300.87015221
71Hepatitis B_Homo sapiens_hsa051610.84794428
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84548926
73Tyrosine metabolism_Homo sapiens_hsa003500.84333970
74Phenylalanine metabolism_Homo sapiens_hsa003600.82595108
75Herpes simplex infection_Homo sapiens_hsa051680.81937033
76Leishmaniasis_Homo sapiens_hsa051400.81649940
77B cell receptor signaling pathway_Homo sapiens_hsa046620.81266330
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.80756516
79Arachidonic acid metabolism_Homo sapiens_hsa005900.77842402
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.76483700
81T cell receptor signaling pathway_Homo sapiens_hsa046600.75471020
82Vitamin digestion and absorption_Homo sapiens_hsa049770.75465258
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.73525385
84Chemokine signaling pathway_Homo sapiens_hsa040620.73213630
85Vitamin B6 metabolism_Homo sapiens_hsa007500.72998038
86Other glycan degradation_Homo sapiens_hsa005110.72265604
87Shigellosis_Homo sapiens_hsa051310.71642406
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.71191570
89Butanoate metabolism_Homo sapiens_hsa006500.69407080
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69274827
91Homologous recombination_Homo sapiens_hsa034400.69087131
92Bile secretion_Homo sapiens_hsa049760.68216195
93TNF signaling pathway_Homo sapiens_hsa046680.67985143
94Phagosome_Homo sapiens_hsa041450.66384765
95Antigen processing and presentation_Homo sapiens_hsa046120.66366028
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.65870832
97Measles_Homo sapiens_hsa051620.65647834
98Carbon metabolism_Homo sapiens_hsa012000.65251000
99Hematopoietic cell lineage_Homo sapiens_hsa046400.65097222
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.65094101
101Pyruvate metabolism_Homo sapiens_hsa006200.64199771
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62691060
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62318988
104Fat digestion and absorption_Homo sapiens_hsa049750.60710451
105Lysine degradation_Homo sapiens_hsa003100.60682082
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58957590
107Pertussis_Homo sapiens_hsa051330.57919496
108Non-homologous end-joining_Homo sapiens_hsa034500.57674619
109Lysosome_Homo sapiens_hsa041420.57458220
110Epstein-Barr virus infection_Homo sapiens_hsa051690.57363155
111Glutathione metabolism_Homo sapiens_hsa004800.56614951
112Sulfur metabolism_Homo sapiens_hsa009200.54857570
113Legionellosis_Homo sapiens_hsa051340.54838788
114Hepatitis C_Homo sapiens_hsa051600.53609373
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52911296
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52764730
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52539378
118Systemic lupus erythematosus_Homo sapiens_hsa053220.51745124
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.51332341
120Arginine and proline metabolism_Homo sapiens_hsa003300.50507888
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47533130
122Nucleotide excision repair_Homo sapiens_hsa034200.46920532
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.46514211
124mTOR signaling pathway_Homo sapiens_hsa041500.44714652
125Apoptosis_Homo sapiens_hsa042100.44437355
126Metabolic pathways_Homo sapiens_hsa011000.44190670
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41749089
128VEGF signaling pathway_Homo sapiens_hsa043700.41342861
129Galactose metabolism_Homo sapiens_hsa000520.41166614
130Viral carcinogenesis_Homo sapiens_hsa052030.41015899
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.39977697
132HTLV-I infection_Homo sapiens_hsa051660.39899387
133Osteoclast differentiation_Homo sapiens_hsa043800.39196553
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39190516
135Inositol phosphate metabolism_Homo sapiens_hsa005620.39100893
136Influenza A_Homo sapiens_hsa051640.38720472
137Insulin resistance_Homo sapiens_hsa049310.38106731
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37737551
139* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37604411
140Protein export_Homo sapiens_hsa030600.37284232
141Acute myeloid leukemia_Homo sapiens_hsa052210.36387732
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36230628
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35438572
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35380946
145Regulation of autophagy_Homo sapiens_hsa041400.32523445
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32286705
147Amoebiasis_Homo sapiens_hsa051460.31702421
148RNA degradation_Homo sapiens_hsa030180.31100967
149Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30944347
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28800785
151Prolactin signaling pathway_Homo sapiens_hsa049170.27103423
152HIF-1 signaling pathway_Homo sapiens_hsa040660.26992835
153Salmonella infection_Homo sapiens_hsa051320.26729179
154Olfactory transduction_Homo sapiens_hsa047400.25701694

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