HGSNAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a lysosomal acetyltransferase, which is one of several enzymes involved in the lysosomal degradation of heparin sulfate. Mutations in this gene are associated with Sanfilippo syndrome C, one type of the lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation, alternative pathway (GO:0006957)5.23260671
2regulation of apoptotic cell clearance (GO:2000425)4.53566131
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.52796606
4protein carboxylation (GO:0018214)4.42905000
5peptidyl-glutamic acid carboxylation (GO:0017187)4.42905000
6regulation of protein activation cascade (GO:2000257)4.23620556
7regulation of complement activation (GO:0030449)4.18045151
8tyrosine metabolic process (GO:0006570)4.17985434
9plasma lipoprotein particle clearance (GO:0034381)4.13787698
10apoptotic cell clearance (GO:0043277)3.92169502
11melanin biosynthetic process (GO:0042438)3.87252300
12mannose metabolic process (GO:0006013)3.75842100
13alpha-linolenic acid metabolic process (GO:0036109)3.69563482
14high-density lipoprotein particle remodeling (GO:0034375)3.69126823
15low-density lipoprotein particle clearance (GO:0034383)3.68389321
16reverse cholesterol transport (GO:0043691)3.60151181
17L-phenylalanine catabolic process (GO:0006559)3.58720001
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.58720001
19phospholipid efflux (GO:0033700)3.56698470
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.54917736
21L-phenylalanine metabolic process (GO:0006558)3.54917736
22urea metabolic process (GO:0019627)3.51207148
23urea cycle (GO:0000050)3.51207148
24complement activation (GO:0006956)3.49759400
25melanin metabolic process (GO:0006582)3.41636948
26aromatic amino acid family catabolic process (GO:0009074)3.37030659
27secondary metabolite biosynthetic process (GO:0044550)3.36209445
28regulation of cholesterol storage (GO:0010885)3.33230346
29positive regulation by symbiont of host defense response (GO:0052509)3.31456389
30modulation by symbiont of host defense response (GO:0052031)3.31456389
31modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.31456389
32modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.31456389
33positive regulation by organism of defense response of other organism involved in symbiotic interact3.31456389
34modulation by symbiont of host immune response (GO:0052553)3.31456389
35sulfur amino acid catabolic process (GO:0000098)3.30446149
36cholesterol efflux (GO:0033344)3.29419446
37negative regulation of fibrinolysis (GO:0051918)3.29050324
38regulation of cholesterol esterification (GO:0010872)3.28013802
39positive regulation of hemostasis (GO:1900048)3.26533961
40positive regulation of blood coagulation (GO:0030194)3.26533961
41plasma lipoprotein particle remodeling (GO:0034369)3.25915999
42protein-lipid complex remodeling (GO:0034368)3.25915999
43macromolecular complex remodeling (GO:0034367)3.25915999
44protein activation cascade (GO:0072376)3.23041378
45opsonization (GO:0008228)3.22638417
46kynurenine metabolic process (GO:0070189)3.22326179
47positive regulation of coagulation (GO:0050820)3.21167409
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.18979914
49bile acid biosynthetic process (GO:0006699)3.18774667
50nitrogen cycle metabolic process (GO:0071941)3.16566266
51tryptophan catabolic process (GO:0006569)3.13786127
52indole-containing compound catabolic process (GO:0042436)3.13786127
53indolalkylamine catabolic process (GO:0046218)3.13786127
54complement activation, classical pathway (GO:0006958)3.11507829
55plasma lipoprotein particle assembly (GO:0034377)3.08588047
56low-density lipoprotein particle remodeling (GO:0034374)3.05301428
57regulation of fibrinolysis (GO:0051917)3.04239102
58tryptophan metabolic process (GO:0006568)3.02969299
59protein-lipid complex assembly (GO:0065005)2.98105091
60aromatic amino acid family metabolic process (GO:0009072)2.96790721
61virion attachment to host cell (GO:0019062)2.95315221
62adhesion of symbiont to host cell (GO:0044650)2.95315221
63dicarboxylic acid biosynthetic process (GO:0043650)2.93340747
64lipoprotein transport (GO:0042953)2.92626830
65fibrinolysis (GO:0042730)2.88740933
66detection of molecule of bacterial origin (GO:0032490)2.88026062
67cysteine metabolic process (GO:0006534)2.87668701
68regulation of humoral immune response (GO:0002920)2.82504609
69aldehyde catabolic process (GO:0046185)2.82302331
70plasma lipoprotein particle organization (GO:0071827)2.81539636
71glyoxylate metabolic process (GO:0046487)2.80892781
72negative regulation of cholesterol transport (GO:0032375)2.80300674
73negative regulation of sterol transport (GO:0032372)2.80300674
74regulation of triglyceride catabolic process (GO:0010896)2.78899844
75amino-acid betaine metabolic process (GO:0006577)2.77236536
76protein-lipid complex subunit organization (GO:0071825)2.77197817
77negative regulation of erythrocyte differentiation (GO:0045647)2.76427985
78phospholipid homeostasis (GO:0055091)2.76218694
79lipoprotein metabolic process (GO:0042157)2.75764958
80positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.73535840
81regulation of interferon-beta biosynthetic process (GO:0045357)2.73369244
82adhesion of symbiont to host (GO:0044406)2.72643742
83regulation of integrin activation (GO:0033623)2.70777382
84endodermal cell differentiation (GO:0035987)2.70686447
85bile acid metabolic process (GO:0008206)2.69843694
86cellular modified amino acid catabolic process (GO:0042219)2.68313695
87positive regulation of lipid catabolic process (GO:0050996)2.68297290
88acute-phase response (GO:0006953)2.68289298
89triglyceride homeostasis (GO:0070328)2.66593955
90acylglycerol homeostasis (GO:0055090)2.66593955
91ketone body metabolic process (GO:1902224)2.65426093
92hemidesmosome assembly (GO:0031581)2.63189073
93skin morphogenesis (GO:0043589)2.61336670
94vascular endothelial growth factor signaling pathway (GO:0038084)2.59986711
95cholesterol transport (GO:0030301)2.58238006
96sterol transport (GO:0015918)2.58238006
97cofactor catabolic process (GO:0051187)2.56491673
98positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.55496139
99lysine metabolic process (GO:0006553)2.55419760
100lysine catabolic process (GO:0006554)2.55419760
101protein heterotrimerization (GO:0070208)2.55254228
102positive regulation of fatty acid beta-oxidation (GO:0032000)2.55117053
103cellular glucuronidation (GO:0052695)2.54619532
104macrophage activation involved in immune response (GO:0002281)2.52355976
105regulation of cholesterol biosynthetic process (GO:0045540)2.51387989
106homocysteine metabolic process (GO:0050667)2.51292939
107protein localization to endosome (GO:0036010)2.49510907
108uronic acid metabolic process (GO:0006063)2.48612966
109glucuronate metabolic process (GO:0019585)2.48612966
110barbed-end actin filament capping (GO:0051016)2.48598885
111regulation of extracellular matrix disassembly (GO:0010715)2.48453231
112ethanol oxidation (GO:0006069)2.47282573
113cell adhesion mediated by integrin (GO:0033627)2.45866485
114stress fiber assembly (GO:0043149)2.42949562
115cellular extravasation (GO:0045123)2.40651807
116negative regulation of fatty acid transport (GO:2000192)2.38816636
117basement membrane organization (GO:0071711)2.38765794
118keratan sulfate catabolic process (GO:0042340)2.35698434
119positive regulation of extracellular matrix organization (GO:1903055)2.29601772
120cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.29403087
121collagen fibril organization (GO:0030199)2.28054413
122substrate-dependent cell migration (GO:0006929)2.27921410
123negative regulation of smooth muscle cell migration (GO:0014912)2.27235121
124cell-substrate junction assembly (GO:0007044)2.25127902
125positive regulation of receptor recycling (GO:0001921)2.24699996
126venous blood vessel morphogenesis (GO:0048845)2.23666033
127collagen metabolic process (GO:0032963)2.22791144
128extracellular matrix assembly (GO:0085029)2.21694565
129collagen catabolic process (GO:0030574)2.21139566
130extracellular matrix disassembly (GO:0022617)2.18478022
131response to muramyl dipeptide (GO:0032495)2.17678329
132cell migration involved in heart development (GO:0060973)2.16752666
133hypotonic response (GO:0006971)2.16435511
134blood vessel maturation (GO:0001955)2.15412873
135negative regulation of interleukin-8 production (GO:0032717)2.15131049
136fibril organization (GO:0097435)2.14974447
137sequestering of extracellular ligand from receptor (GO:0035581)2.12837791
138response to laminar fluid shear stress (GO:0034616)2.11352543
139extracellular fibril organization (GO:0043206)2.09697742
140response to fluid shear stress (GO:0034405)2.09178453
141multicellular organismal macromolecule metabolic process (GO:0044259)2.08825400
142insulin-like growth factor receptor signaling pathway (GO:0048009)2.08554496
143vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.08191791
144multicellular organismal catabolic process (GO:0044243)2.05963040
145positive regulation of blood vessel endothelial cell migration (GO:0043536)2.04938258
146lymph vessel development (GO:0001945)2.03988654
147surfactant homeostasis (GO:0043129)2.02054109
148multicellular organismal metabolic process (GO:0044236)2.01431237
149positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)1.99950875
150positive regulation of endothelial cell apoptotic process (GO:2000353)1.99252022
151type B pancreatic cell proliferation (GO:0044342)1.98051083
152negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)1.97993454
153import into cell (GO:0098657)1.96899061
154negative regulation of type 2 immune response (GO:0002829)1.95895187
155positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.94862964
156cellular response to epinephrine stimulus (GO:0071872)1.94636462
157negative regulation of cell killing (GO:0031342)1.94145495
158negative regulation of leukocyte mediated cytotoxicity (GO:0001911)1.94145495
159semaphorin-plexin signaling pathway (GO:0071526)1.93726279
160endothelium development (GO:0003158)1.93402251
161chondroitin sulfate biosynthetic process (GO:0030206)1.92330157
162regulation of leukocyte degranulation (GO:0043300)1.91954690
163regulation of macrophage cytokine production (GO:0010935)1.91813973
164glial cell migration (GO:0008347)1.91548396
165regulation of collagen metabolic process (GO:0010712)1.89725753
166regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.89689619
167macroautophagy (GO:0016236)1.88924850
168regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.88376315
169peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)1.87454845
170negative regulation of granulocyte differentiation (GO:0030853)1.86761685
171regulation of membrane protein ectodomain proteolysis (GO:0051043)1.86643651
172angiogenesis involved in wound healing (GO:0060055)1.85195750
173renal filtration (GO:0097205)1.85102951
174positive regulation of histone deacetylation (GO:0031065)1.84543335
175response to manganese ion (GO:0010042)1.83033158
176pinocytosis (GO:0006907)1.82467514
177regulation of extracellular matrix organization (GO:1903053)1.81865204
178germinal center formation (GO:0002467)1.81856486
179antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.81597404
180response to peptidoglycan (GO:0032494)1.81550153
181positive regulation of cholesterol efflux (GO:0010875)1.81245774
182regulation of chemokine biosynthetic process (GO:0045073)1.78724476
183negative regulation of complement activation (GO:0045916)1.77677235
184glomerular filtration (GO:0003094)1.77394142
185dichotomous subdivision of an epithelial terminal unit (GO:0060600)1.77144565
186cytoskeletal anchoring at plasma membrane (GO:0007016)1.76903018
187membrane protein ectodomain proteolysis (GO:0006509)1.76769460
188negative regulation of nitric oxide biosynthetic process (GO:0045019)1.76606617
189regulation of mast cell degranulation (GO:0043304)1.75412140
190cartilage development involved in endochondral bone morphogenesis (GO:0060351)1.74161692
191positive regulation of leukocyte degranulation (GO:0043302)1.73305042
192amyloid precursor protein catabolic process (GO:0042987)1.73266614
193extracellular matrix organization (GO:0030198)1.73190977
194interleukin-1-mediated signaling pathway (GO:0070498)1.73042058

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.38434422
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.69070433
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.97073571
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.85951674
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.27193443
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.08300085
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.95439515
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.91726603
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.85853590
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.63708805
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.51107857
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44594042
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.40567638
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.37721525
15* IRF8_27001747_Chip-Seq_BMDM_Mouse2.36693456
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16725496
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15733104
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.11786106
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08417273
20CLOCK_20551151_ChIP-Seq_293T_Human1.85865165
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77498438
22MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63892516
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63160274
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60766738
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58437919
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.56245217
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.50444083
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44642752
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.43506358
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43395211
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39574983
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38832950
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38529909
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38529909
35DROSHA_22980978_ChIP-Seq_HELA_Human1.37000550
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36820982
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.35776994
38TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.34176922
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33884582
40LXR_22292898_ChIP-Seq_THP-1_Human1.30818670
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29032260
42KDM2B_26808549_Chip-Seq_DND41_Human1.27937946
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.25940914
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24996727
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24295600
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23865453
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23728958
48SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22963822
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22569644
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21714240
51TCF7_22412390_ChIP-Seq_EML_Mouse1.21039932
52NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20723065
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20489207
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20171396
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19219736
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.18245631
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17664338
58TBX20_22328084_ChIP-Seq_HEART_Mouse1.17432000
59TBX20_22080862_ChIP-Seq_HEART_Mouse1.17432000
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17206203
61VDR_24787735_ChIP-Seq_THP-1_Human1.16028631
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14788024
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14756757
64SPI1_23127762_ChIP-Seq_K562_Human1.13607284
65VDR_21846776_ChIP-Seq_THP-1_Human1.13547135
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12761831
67* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12553367
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11936074
69* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10540864
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07604606
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06622125
72P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06534820
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05260561
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.03708738
75SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01977122
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00326542
77RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00325151
78EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00325151
79EP300_21415370_ChIP-Seq_HL-1_Mouse0.99625002
80* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99561793
81EGR1_19032775_ChIP-ChIP_M12_Human0.99274697
82RUNX_20019798_ChIP-Seq_JUKART_Human0.99164829
83TP53_16413492_ChIP-PET_HCT116_Human0.98777308
84SCL_19346495_ChIP-Seq_HPC-7_Human0.98367459
85DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97299474
86SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97231717
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96755669
88GATA2_19941826_ChIP-Seq_K562_Human0.96626506
89SOX2_20726797_ChIP-Seq_SW620_Human0.95091908
90CJUN_26792858_Chip-Seq_BT549_Human0.94332304
91WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94307588
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93533209
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93520692
94JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92490466
95PU_27001747_Chip-Seq_BMDM_Mouse0.92199921
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91252391
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90890789
98AHR_22903824_ChIP-Seq_MCF-7_Human0.90665429
99GATA1_19941826_ChIP-Seq_K562_Human0.90353997
100GATA1_19941827_ChIP-Seq_MEL_Mouse0.90180568
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90008346
102PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89553511
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89539712
104RNF2_27304074_Chip-Seq_ESCs_Mouse0.89526491
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89001033
106UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87756320
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87621731
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.86883178
109ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85494968
110ERG_21242973_ChIP-ChIP_JURKAT_Human0.83439017
111RACK7_27058665_Chip-Seq_MCF-7_Human0.83293519
112ELK3_25401928_ChIP-Seq_HUVEC_Human0.83200829
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.80457154
114EGR1_19374776_ChIP-ChIP_THP-1_Human0.80095152
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79900106
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.79104179
117HNF4A_19822575_ChIP-Seq_HepG2_Human0.78836213
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78380368
119E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78124725
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78058698
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.77952186
122SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77910754
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75255167
124FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.74672106
125RXR_22108803_ChIP-Seq_LS180_Human0.73618189
126CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73331528
127VDR_24763502_ChIP-Seq_THP-1_Human0.72893821
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.72088004
129P300_27058665_Chip-Seq_ZR-75-30cells_Human0.71691407
130STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.70875846
131TP63_17297297_ChIP-ChIP_HaCaT_Human0.70400164
132TP53_18474530_ChIP-ChIP_U2OS_Human0.69859928
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69241048
134BCAT_22108803_ChIP-Seq_LS180_Human0.68090949
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67744486
136KDM2B_26808549_Chip-Seq_K562_Human0.66220552
137FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66113034
138* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66089115
139SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66046463
140KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.65251903

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.65827331
2MP0005360_urolithiasis4.16178068
3MP0009840_abnormal_foam_cell3.82569274
4MP0005058_abnormal_lysosome_morphology3.80971509
5MP0005365_abnormal_bile_salt3.33256897
6MP0005275_abnormal_skin_tensile3.27166051
7MP0005085_abnormal_gallbladder_physiolo2.98978110
8MP0008875_abnormal_xenobiotic_pharmacok2.84008884
9MP0005503_abnormal_tendon_morphology2.79291161
10MP0003191_abnormal_cellular_cholesterol2.78506694
11MP0010329_abnormal_lipoprotein_level2.73762479
12MP0003436_decreased_susceptibility_to2.51298683
13MP0003195_calcinosis2.47995184
14MP0000604_amyloidosis2.26822101
15MP0003303_peritoneal_inflammation2.21542214
16MP0004272_abnormal_basement_membrane2.19981398
17MP0003705_abnormal_hypodermis_morpholog2.07907802
18MP0003172_abnormal_lysosome_physiology2.06186423
19MP0005083_abnormal_biliary_tract2.03178132
20MP0008438_abnormal_cutaneous_collagen1.99977183
21MP0003075_altered_response_to1.98363882
22MP0006054_spinal_hemorrhage1.97494340
23MP0003690_abnormal_glial_cell1.95445697
24MP0003828_pulmonary_edema1.91618075
25MP0002419_abnormal_innate_immunity1.83350901
26MP0003724_increased_susceptibility_to1.82063015
27MP0003252_abnormal_bile_duct1.80937315
28MP0000372_irregular_coat_pigmentation1.80201308
29MP0005409_darkened_coat_color1.79167287
30MP0005332_abnormal_amino_acid1.75592995
31MP0009384_cardiac_valve_regurgitation1.70211340
32MP0003300_gastrointestinal_ulcer1.67649651
33MP0000767_abnormal_smooth_muscle1.65506028
34MP0001533_abnormal_skeleton_physiology1.60709215
35MP0000609_abnormal_liver_physiology1.58300167
36MP0002118_abnormal_lipid_homeostasis1.54724143
37MP0005464_abnormal_platelet_physiology1.52036635
38MP0002254_reproductive_system_inflammat1.50251814
39MP0003806_abnormal_nucleotide_metabolis1.49828319
40MP0003656_abnormal_erythrocyte_physiolo1.43823945
41MP0006082_CNS_inflammation1.41344346
42MP0002060_abnormal_skin_morphology1.40786234
43MP0005171_absent_coat_pigmentation1.37322781
44MP0001542_abnormal_bone_strength1.36106010
45MP0000371_diluted_coat_color1.35458174
46MP0002896_abnormal_bone_mineralization1.35346697
47MP0002933_joint_inflammation1.33973049
48MP0004019_abnormal_vitamin_homeostasis1.33449665
49MP0005584_abnormal_enzyme/coenzyme_acti1.33178246
50MP0005408_hypopigmentation1.31304953
51MP0003329_amyloid_beta_deposits1.29279074
52MP0009764_decreased_sensitivity_to1.28601744
53MP0005166_decreased_susceptibility_to1.28519353
54MP0002295_abnormal_pulmonary_circulatio1.28488012
55MP0003011_delayed_dark_adaptation1.28122811
56MP0003045_fibrosis1.27341174
57MP0005025_abnormal_response_to1.26778073
58MP0003279_aneurysm1.26722532
59MP0000343_altered_response_to1.24056332
60MP0002138_abnormal_hepatobiliary_system1.23805486
61MP0000013_abnormal_adipose_tissue1.23411357
62MP0005508_abnormal_skeleton_morphology1.20449202
63MP0005319_abnormal_enzyme/_coenzyme1.20374717
64MP0001666_abnormal_nutrient_absorption1.19298820
65MP0008469_abnormal_protein_level1.18495653
66MP0004947_skin_inflammation1.17129664
67MP0005000_abnormal_immune_tolerance1.16042811
68MP0001790_abnormal_immune_system1.15589070
69MP0005387_immune_system_phenotype1.15589070
70MP0004858_abnormal_nervous_system1.14867110
71MP0009763_increased_sensitivity_to1.11882941
72MP0001879_abnormal_lymphatic_vessel1.11487849
73MP0005670_abnormal_white_adipose1.10465865
74MP0002090_abnormal_vision1.10438414
75MP0005257_abnormal_intraocular_pressure1.10387135
76MP0009785_altered_susceptibility_to1.09359173
77MP0008004_abnormal_stomach_pH1.07997174
78MP0003183_abnormal_peptide_metabolism1.06394625
79MP0005164_abnormal_response_to1.06217172
80MP0000751_myopathy1.06145744
81MP0001835_abnormal_antigen_presentation1.05258827
82MP0004130_abnormal_muscle_cell1.05107361
83MP0004883_abnormal_blood_vessel1.04743170
84MP0002998_abnormal_bone_remodeling1.04437865
85MP0009643_abnormal_urine_homeostasis1.02618168
86MP0003566_abnormal_cell_adhesion1.02021884
87MP0004510_myositis1.01487064
88MP0001849_ear_inflammation1.01421015
89MP0001845_abnormal_inflammatory_respons1.00808284
90MP0000569_abnormal_digit_pigmentation0.98403191
91MP0005023_abnormal_wound_healing0.97001188
92MP0005167_abnormal_blood-brain_barrier0.96000105
93MP0005375_adipose_tissue_phenotype0.94295192
94MP0002108_abnormal_muscle_morphology0.93680356
95MP0002148_abnormal_hypersensitivity_rea0.92704391
96MP0000249_abnormal_blood_vessel0.91928534
97MP0005623_abnormal_meninges_morphology0.91559306
98MP0000465_gastrointestinal_hemorrhage0.89682685
99MP0002133_abnormal_respiratory_system0.89039225
100MP0005388_respiratory_system_phenotype0.89039225
101MP0002877_abnormal_melanocyte_morpholog0.88480894
102MP0006138_congestive_heart_failure0.88293771
103MP0000598_abnormal_liver_morphology0.87975563
104MP0000003_abnormal_adipose_tissue0.86919667
105MP0002452_abnormal_antigen_presenting0.85267341
106MP0000685_abnormal_immune_system0.84847443
107MP0002168_other_aberrant_phenotype0.84669400
108MP0005197_abnormal_uvea_morphology0.82523835
109MP0009278_abnormal_bone_marrow0.82114590
110MP0001958_emphysema0.82079938
111MP0001764_abnormal_homeostasis0.81705575
112MP0000858_altered_metastatic_potential0.81236735
113MP0003795_abnormal_bone_structure0.80726322
114MP0005666_abnormal_adipose_tissue0.80061596
115MP0001324_abnormal_eye_pigmentation0.79054842
116MP0005451_abnormal_body_composition0.78152195
117MP0003448_altered_tumor_morphology0.78061936
118MP0001853_heart_inflammation0.77950720
119MP0010155_abnormal_intestine_physiology0.77268763
120MP0002405_respiratory_system_inflammati0.76837752
121MP0005390_skeleton_phenotype0.76303620
122MP0009780_abnormal_chondrocyte_physiolo0.76258014
123MP0003186_abnormal_redox_activity0.76151764
124MP0010368_abnormal_lymphatic_system0.75699266
125MP0001851_eye_inflammation0.74763680
126MP0005248_abnormal_Harderian_gland0.72642284
127MP0002136_abnormal_kidney_physiology0.72508955
128MP0002909_abnormal_adrenal_gland0.72403736
129MP0005535_abnormal_body_temperature0.71587156
130MP0001614_abnormal_blood_vessel0.71145277
131MP0005165_increased_susceptibility_to0.70579485
132MP0002971_abnormal_brown_adipose0.70388669
133MP0009697_abnormal_copulation0.70228823
134MP0003453_abnormal_keratinocyte_physiol0.69867708
135MP0005595_abnormal_vascular_smooth0.69766157
136MP0003091_abnormal_cell_migration0.69662865
137MP0000733_abnormal_muscle_development0.67446454
138MP0002128_abnormal_blood_circulation0.66540910
139MP0001243_abnormal_dermal_layer0.66478161
140MP0005076_abnormal_cell_differentiation0.63696334
141MP0004782_abnormal_surfactant_physiolog0.61649947
142MP0002113_abnormal_skeleton_development0.60349624

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.94727517
2Complement deficiency (HP:0004431)5.61114623
3Abnormality of complement system (HP:0005339)5.16193490
4Deep venous thrombosis (HP:0002625)5.08202941
5Glomerulonephritis (HP:0000099)4.94054392
6Protrusio acetabuli (HP:0003179)4.82619964
7Vacuolated lymphocytes (HP:0001922)4.47809519
8Recurrent gram-negative bacterial infections (HP:0005420)4.46859298
9Xanthomatosis (HP:0000991)4.46045991
10Prolonged partial thromboplastin time (HP:0003645)4.44860434
11Premature rupture of membranes (HP:0001788)4.13746012
12Joint hemorrhage (HP:0005261)4.07111270
13* Dysostosis multiplex (HP:0000943)3.80973166
14Increased cerebral lipofuscin (HP:0011813)3.76144895
15Aortic aneurysm (HP:0004942)3.63497520
16Hyperlipoproteinemia (HP:0010980)3.60220719
17Aortic dissection (HP:0002647)3.58099428
18Abnormality of the common coagulation pathway (HP:0010990)3.52724703
19Abnormality of aromatic amino acid family metabolism (HP:0004338)3.49650153
20Vascular tortuosity (HP:0004948)3.48454722
21Nephritis (HP:0000123)3.43966052
22Abnormality of monocarboxylic acid metabolism (HP:0010996)3.39653872
23* Mucopolysacchariduria (HP:0008155)3.39492059
24* Urinary glycosaminoglycan excretion (HP:0003541)3.39492059
25Intrahepatic cholestasis (HP:0001406)3.35569964
26Atrophic scars (HP:0001075)3.28799610
27Hypoalphalipoproteinemia (HP:0003233)3.28036591
28* Abnormality of mucopolysaccharide metabolism (HP:0011020)3.22011013
29* Abnormality of polysaccharide metabolism (HP:0011012)3.22011013
30* Abnormality of glycosaminoglycan metabolism (HP:0004371)3.22011013
31Arterial tortuosity (HP:0005116)3.21407640
32Increased neuronal autofluorescent lipopigment (HP:0002074)3.17825111
33Myocardial infarction (HP:0001658)3.15938983
34Eczematoid dermatitis (HP:0000976)3.11634908
35Amyloidosis (HP:0011034)2.99067549
36Recurrent abscess formation (HP:0002722)2.94332220
37Follicular hyperkeratosis (HP:0007502)2.81184774
38Axonal loss (HP:0003447)2.80156592
39Hypolipoproteinemia (HP:0010981)2.79961491
40Fragile skin (HP:0001030)2.73044729
41Hypercholesterolemia (HP:0003124)2.70218865
42Abnormality of macrophages (HP:0004311)2.69829263
43Esophageal varix (HP:0002040)2.69348777
44Peritonitis (HP:0002586)2.65543448
45Tetraparesis (HP:0002273)2.65036625
46Bladder diverticulum (HP:0000015)2.64874244
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.60845031
48Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.60530022
49Abnormality of the lumbar spine (HP:0100712)2.60153273
50Recurrent bacterial skin infections (HP:0005406)2.59998688
51Hypobetalipoproteinemia (HP:0003563)2.57757912
52Epidermoid cyst (HP:0200040)2.54378760
53Abnormality of the intrinsic pathway (HP:0010989)2.53374204
54Abnormality of liposaccharide metabolism (HP:0010968)2.52968192
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.52968192
56Abnormality of glycolipid metabolism (HP:0010969)2.52968192
57Genu recurvatum (HP:0002816)2.52404556
58Increased variability in muscle fiber diameter (HP:0003557)2.51630787
59Soft skin (HP:0000977)2.51099589
60Wormian bones (HP:0002645)2.49151158
61Aneurysm (HP:0002617)2.47570065
62Menorrhagia (HP:0000132)2.46518327
63Dilatation of the ascending aorta (HP:0005111)2.46205516
64Mitral stenosis (HP:0001718)2.42118837
65Hyperammonemia (HP:0001987)2.38267814
66Obstructive sleep apnea (HP:0002870)2.34939216
67Ankle contracture (HP:0006466)2.34852060
68Mitral valve prolapse (HP:0001634)2.34297047
69Blue sclerae (HP:0000592)2.34115736
70Spinal rigidity (HP:0003306)2.32684622
71Neurofibrillary tangles (HP:0002185)2.31682962
72Thoracic kyphosis (HP:0002942)2.23647843
73Type 1 muscle fiber predominance (HP:0003803)2.23589810
74Overgrowth (HP:0001548)2.22537077
75Abnormal gallbladder physiology (HP:0012438)2.21648439
76Cholecystitis (HP:0001082)2.21648439
77Skin nodule (HP:0200036)2.19272766
78Cervical subluxation (HP:0003308)2.18757963
79Aortic regurgitation (HP:0001659)2.18367589
80* Joint stiffness (HP:0001387)2.16231744
81Gingivitis (HP:0000230)2.15004303
82Neonatal short-limb short stature (HP:0008921)2.14911539
83Pustule (HP:0200039)2.14718302
84Upper motor neuron abnormality (HP:0002127)2.14708999
85Gingival bleeding (HP:0000225)2.13748331
86Abnormality of skeletal muscle fiber size (HP:0012084)2.13476419
87Sensorimotor neuropathy (HP:0007141)2.12653269
88Abnormality of dentin (HP:0010299)2.10782497
89Ketosis (HP:0001946)2.10328151
90J-shaped sella turcica (HP:0002680)2.09968897
91Joint laxity (HP:0001388)2.09855384
92Thin bony cortex (HP:0002753)2.08923625
93Hepatocellular carcinoma (HP:0001402)2.08408635
94Spontaneous hematomas (HP:0007420)2.04653133
95Global brain atrophy (HP:0002283)2.03473991
96Abnormality of sulfur amino acid metabolism (HP:0004339)2.03459002
97Turricephaly (HP:0000262)2.02632279
98Fat malabsorption (HP:0002630)2.02160033
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00979799
100Cerebral aneurysm (HP:0004944)1.97443513
101Mitral regurgitation (HP:0001653)1.96665788
102Retinal atrophy (HP:0001105)1.95298522
103Pathologic fracture (HP:0002756)1.94538321
104Hyperextensible skin (HP:0000974)1.93088562
105* Loss of speech (HP:0002371)1.92377127
106Cerebral inclusion bodies (HP:0100314)1.89775905
107Hydroxyprolinuria (HP:0003080)1.89519733
108Abnormality of proline metabolism (HP:0010907)1.89519733
109* Ovoid vertebral bodies (HP:0003300)1.89244894
110Myositis (HP:0100614)1.87879916
111Broad face (HP:0000283)1.87075995
112Slender build (HP:0001533)1.86341365
113Abnormality of purine metabolism (HP:0004352)1.84551645
114Striae distensae (HP:0001065)1.84423971
115Aortic valve stenosis (HP:0001650)1.83128596
116Abnormality of methionine metabolism (HP:0010901)1.81343875
117Flared iliac wings (HP:0002869)1.80480461
118Osteolytic defects of the phalanges of the hand (HP:0009771)1.79891624
119Osteolytic defects of the hand bones (HP:0009699)1.79891624
120Infantile muscular hypotonia (HP:0008947)1.79726343
121Beaking of vertebral bodies (HP:0004568)1.77612070
122Hypoplasia of the iris (HP:0007676)1.77426326
123Peripheral demyelination (HP:0011096)1.77389187
124* Asymmetric septal hypertrophy (HP:0001670)1.75841756
125Spondylolisthesis (HP:0003302)1.75733661
126Abnormality of aspartate family amino acid metabolism (HP:0010899)1.75504696
127Interstitial pulmonary disease (HP:0006530)1.74938248
128Coxa vara (HP:0002812)1.73887003
129Increased connective tissue (HP:0009025)1.73867954
130Shallow orbits (HP:0000586)1.73284051
131Wide anterior fontanel (HP:0000260)1.72928195
132Disproportionate tall stature (HP:0001519)1.71902271
133Abnormality of nucleobase metabolism (HP:0010932)1.71123815
134Hand muscle atrophy (HP:0009130)1.70510777
135Vascular calcification (HP:0004934)1.70284556
136Abnormality of the vasculature of the conjunctiva (HP:0008054)1.69854364
137Periodontitis (HP:0000704)1.69520355
138Recurrent skin infections (HP:0001581)1.68242065
139Vertebral compression fractures (HP:0002953)1.67801211
140Supranuclear gaze palsy (HP:0000605)1.67768407
141Paraparesis (HP:0002385)1.67560485
142Blue irides (HP:0000635)1.66035361
143Broad metatarsal (HP:0001783)1.65541547
144Disinhibition (HP:0000734)1.65374985
145Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.65262561
146Mildly elevated creatine phosphokinase (HP:0008180)1.65224044
147Long toe (HP:0010511)1.65049880
148Neuronal loss in central nervous system (HP:0002529)1.64684762
149Osteoarthritis (HP:0002758)1.64604863
150Abnormality of fatty-acid metabolism (HP:0004359)1.64586900
151Short nail (HP:0001799)1.62762369
152Orchitis (HP:0100796)1.62666215
153Abnormality of the acetabulum (HP:0003170)1.61053094
154Emphysema (HP:0002097)1.60949854
155Hypoplasia of the odontoid process (HP:0003311)1.59175354
156Bruising susceptibility (HP:0000978)1.59171934
157Hematochezia (HP:0002573)1.56645496
158Persistence of primary teeth (HP:0006335)1.56158983
159Hypoventilation (HP:0002791)1.55745033
160Natal tooth (HP:0000695)1.55667492
161Hemorrhage of the eye (HP:0011885)1.53802383
162Cardiovascular calcification (HP:0011915)1.53479466
163Biconcave vertebral bodies (HP:0004586)1.53357827
164Pulmonary artery stenosis (HP:0004415)1.52606798
165Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.52083569
166Polycythemia (HP:0001901)1.52018628
167Stroke (HP:0001297)1.51827311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.79051240
2ERN13.77038655
3TRIB32.94533240
4CAMK1D2.33377559
5BLK2.25426501
6PKN22.11290870
7EPHB12.10395495
8RIPK12.00242912
9TYK21.99405455
10DAPK21.97269056
11TBK11.96897498
12BMX1.95378581
13RIPK41.91190765
14CDC42BPA1.87424122
15MET1.86192034
16CAMK1G1.80565312
17CAMKK11.79885584
18PRPF4B1.78176177
19TAOK31.72489176
20CAMKK21.72109677
21PTK61.71731732
22FGFR41.64565838
23TGFBR21.62290191
24MAP3K61.60142216
25EPHA31.59446201
26SIK11.58376249
27PRKD21.55185147
28MYLK1.54946229
29MAP3K131.52996034
30IRAK31.40753862
31JAK11.38305842
32FES1.33779830
33EPHB21.33623472
34KSR21.32583781
35FGR1.29476392
36CSK1.29042343
37ICK1.27207032
38MARK21.26716120
39PDGFRB1.19523494
40SCYL21.18470977
41BCKDK1.17185317
42RPS6KA21.12902282
43MAP3K21.12595103
44MAP2K31.12551706
45NEK91.10446359
46KIT1.09615261
47MAP4K11.07615821
48HIPK21.02751863
49MAP3K140.98550853
50TRPM70.98534226
51PRKCH0.98507793
52PTK20.97685801
53JAK20.96799428
54ZAP700.95763556
55MAP2K40.95561961
56NTRK10.94656811
57HCK0.94363667
58SGK30.92781947
59PIK3CG0.92271012
60MAP3K110.92258251
61TNK20.88518695
62LATS10.88401248
63IRAK40.88111319
64MAP3K90.86411040
65MAP3K10.85587104
66ABL20.84766767
67FGFR30.82805961
68MAP3K30.82512053
69GRK70.82453252
70TTN0.81359828
71TESK10.80382344
72MARK30.80313184
73MOS0.79686735
74FER0.77942710
75TAOK10.76679574
76ERBB40.76098984
77GRK60.75948558
78PDPK10.75914751
79MAPK150.74978920
80LRRK20.74240049
81KDR0.72386948
82RET0.71690418
83PRKD30.71194671
84IKBKE0.71164041
85PAK20.70245081
86TAOK20.70103509
87RPS6KC10.70061301
88RPS6KL10.70061301
89MAPK40.69410635
90MAPK120.68970069
91MTOR0.67684403
92MATK0.64885665
93MAP2K10.64189462
94TIE10.64085600
95IGF1R0.63428938
96PTK2B0.61225194
97RPS6KA60.60764885
98CSF1R0.60631925
99AKT30.60076120
100PRKD10.59832551
101MAPKAPK30.59783151
102DMPK0.58372461
103EGFR0.57480637
104DDR20.56906086
105BTK0.56722200
106ARAF0.52770009
107PDK10.52568184
108PDGFRA0.52448863
109PAK40.51393814
110MAP2K60.51296142
111MAPK110.51167350
112CDK120.50984048
113CDK60.50921433
114JAK30.50826042
115PAK60.50448799
116INSRR0.50417560
117FYN0.49889580
118STK380.49482771
119ITK0.49374636
120FGFR10.48545766
121NTRK30.48060566
122SGK20.46935085
123PRKG20.43428235
124GSK3A0.43084568
125LCK0.42989512
126MAPK70.41848688
127MAP3K70.39847215
128SIK20.39055107
129FRK0.38802307
130MINK10.37892595
131RPS6KA40.37297682
132PRKAA20.36774757
133LMTK20.36402267
134SRC0.36239702
135PRKCZ0.35764896
136FLT30.35415387

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.28258595
2Complement and coagulation cascades_Homo sapiens_hsa046103.56903598
3Nitrogen metabolism_Homo sapiens_hsa009103.18568568
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.18328869
5Caffeine metabolism_Homo sapiens_hsa002322.61951152
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.38489683
7Arginine biosynthesis_Homo sapiens_hsa002202.38098726
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.32169361
9* Glycosaminoglycan degradation_Homo sapiens_hsa005312.19688189
10Other glycan degradation_Homo sapiens_hsa005112.11947211
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.01525922
12ECM-receptor interaction_Homo sapiens_hsa045121.82177001
13Fatty acid degradation_Homo sapiens_hsa000711.79347382
14* Lysosome_Homo sapiens_hsa041421.77617882
15PPAR signaling pathway_Homo sapiens_hsa033201.69170677
16Tryptophan metabolism_Homo sapiens_hsa003801.65725057
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65138416
18Histidine metabolism_Homo sapiens_hsa003401.51440708
19Focal adhesion_Homo sapiens_hsa045101.48866290
20Tyrosine metabolism_Homo sapiens_hsa003501.43478952
21Bile secretion_Homo sapiens_hsa049761.38616655
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36180979
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35234351
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32773906
25Peroxisome_Homo sapiens_hsa041461.31638857
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.30547653
27Fatty acid metabolism_Homo sapiens_hsa012121.30153799
28Starch and sucrose metabolism_Homo sapiens_hsa005001.30112407
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28016999
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25660479
31Pertussis_Homo sapiens_hsa051331.25104365
32Chemical carcinogenesis_Homo sapiens_hsa052041.18263886
33beta-Alanine metabolism_Homo sapiens_hsa004101.17251825
34Notch signaling pathway_Homo sapiens_hsa043301.14514088
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12546116
36Platelet activation_Homo sapiens_hsa046111.12076598
37Acute myeloid leukemia_Homo sapiens_hsa052211.08275079
38Prion diseases_Homo sapiens_hsa050201.05399080
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.04998768
40ABC transporters_Homo sapiens_hsa020101.03641700
41Phospholipase D signaling pathway_Homo sapiens_hsa040721.02246326
42GnRH signaling pathway_Homo sapiens_hsa049121.02074695
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.01961366
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01761995
45VEGF signaling pathway_Homo sapiens_hsa043701.01670951
46Dilated cardiomyopathy_Homo sapiens_hsa054141.00562694
47Dorso-ventral axis formation_Homo sapiens_hsa043201.00298485
48Leishmaniasis_Homo sapiens_hsa051401.00002072
49Malaria_Homo sapiens_hsa051440.99482332
50Protein digestion and absorption_Homo sapiens_hsa049740.96602096
51Phenylalanine metabolism_Homo sapiens_hsa003600.96411622
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95526609
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.94390198
54Butanoate metabolism_Homo sapiens_hsa006500.94204869
55Chronic myeloid leukemia_Homo sapiens_hsa052200.94147687
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93052984
57Phagosome_Homo sapiens_hsa041450.92942635
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92542951
59Retinol metabolism_Homo sapiens_hsa008300.90471245
60B cell receptor signaling pathway_Homo sapiens_hsa046620.89275969
61Hepatitis C_Homo sapiens_hsa051600.86162493
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86076865
63Propanoate metabolism_Homo sapiens_hsa006400.85103525
64Prolactin signaling pathway_Homo sapiens_hsa049170.84326432
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.84059547
66Renin secretion_Homo sapiens_hsa049240.80660484
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80602300
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80185843
69Steroid biosynthesis_Homo sapiens_hsa001000.79867430
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78965321
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77870760
72Estrogen signaling pathway_Homo sapiens_hsa049150.77783292
73Renal cell carcinoma_Homo sapiens_hsa052110.77744208
74Osteoclast differentiation_Homo sapiens_hsa043800.75759240
75Pancreatic cancer_Homo sapiens_hsa052120.75756260
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75417930
77Choline metabolism in cancer_Homo sapiens_hsa052310.75370603
78Tuberculosis_Homo sapiens_hsa051520.74876124
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73505973
80Sulfur metabolism_Homo sapiens_hsa009200.72479056
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.71656107
82Small cell lung cancer_Homo sapiens_hsa052220.71113790
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71070931
84Endocytosis_Homo sapiens_hsa041440.70122146
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.68393730
86Fat digestion and absorption_Homo sapiens_hsa049750.67991230
87Bladder cancer_Homo sapiens_hsa052190.67613783
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.66870130
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66569525
90Hematopoietic cell lineage_Homo sapiens_hsa046400.64884159
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64808776
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64792592
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62418491
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61917174
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61783493
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61330829
97Pentose phosphate pathway_Homo sapiens_hsa000300.61116443
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61089451
99Carbon metabolism_Homo sapiens_hsa012000.59715115
100Non-small cell lung cancer_Homo sapiens_hsa052230.59493370
101Glioma_Homo sapiens_hsa052140.59400639
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59263182
103MAPK signaling pathway_Homo sapiens_hsa040100.58775884
104Amoebiasis_Homo sapiens_hsa051460.58276728
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58096210
106Galactose metabolism_Homo sapiens_hsa000520.57859736
107Influenza A_Homo sapiens_hsa051640.57815394
108Fatty acid biosynthesis_Homo sapiens_hsa000610.57809381
109Ovarian steroidogenesis_Homo sapiens_hsa049130.57201433
110Rap1 signaling pathway_Homo sapiens_hsa040150.57135736
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56705919
112Sphingolipid metabolism_Homo sapiens_hsa006000.56378728
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.55995969
114Biosynthesis of amino acids_Homo sapiens_hsa012300.55986447
115Endometrial cancer_Homo sapiens_hsa052130.55946372
116Vitamin digestion and absorption_Homo sapiens_hsa049770.55850868
117Insulin signaling pathway_Homo sapiens_hsa049100.55406478
118Oxytocin signaling pathway_Homo sapiens_hsa049210.55189975
119mTOR signaling pathway_Homo sapiens_hsa041500.55156767
120Insulin resistance_Homo sapiens_hsa049310.54796140
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54151762
122ErbB signaling pathway_Homo sapiens_hsa040120.52720163
123Inositol phosphate metabolism_Homo sapiens_hsa005620.52700943
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52104305
125T cell receptor signaling pathway_Homo sapiens_hsa046600.51212202
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50885970
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50527025
128Hepatitis B_Homo sapiens_hsa051610.50511938
129Glycerolipid metabolism_Homo sapiens_hsa005610.49810591
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49658477
131Axon guidance_Homo sapiens_hsa043600.49264499
132Type II diabetes mellitus_Homo sapiens_hsa049300.49122509
133Ras signaling pathway_Homo sapiens_hsa040140.49078286
134Pyruvate metabolism_Homo sapiens_hsa006200.47932470
135Selenocompound metabolism_Homo sapiens_hsa004500.44830322
136Lysine degradation_Homo sapiens_hsa003100.43810638
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41626996
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41483063
139Fructose and mannose metabolism_Homo sapiens_hsa000510.41007084
140Arginine and proline metabolism_Homo sapiens_hsa003300.40900722
141Folate biosynthesis_Homo sapiens_hsa007900.38561954
142Legionellosis_Homo sapiens_hsa051340.38122435
143Sulfur relay system_Homo sapiens_hsa041220.37771945
144Fatty acid elongation_Homo sapiens_hsa000620.37268205
145Mineral absorption_Homo sapiens_hsa049780.35835659
146Rheumatoid arthritis_Homo sapiens_hsa053230.35578381
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35467024
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32248226
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32223876
150Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29932951
151Toxoplasmosis_Homo sapiens_hsa051450.29491219
152Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28458144
153Salmonella infection_Homo sapiens_hsa051320.27125814
154Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26529663
155Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26097908
156Leukocyte transendothelial migration_Homo sapiens_hsa046700.24961184
157Chemokine signaling pathway_Homo sapiens_hsa040620.24644281
158Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24216653
159Proteoglycans in cancer_Homo sapiens_hsa052050.22432699
160Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22404474
161Cysteine and methionine metabolism_Homo sapiens_hsa002700.22268781
162Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22268304
163African trypanosomiasis_Homo sapiens_hsa051430.22210887
164Shigellosis_Homo sapiens_hsa051310.22099841
165TNF signaling pathway_Homo sapiens_hsa046680.21633813
166Central carbon metabolism in cancer_Homo sapiens_hsa052300.20929451

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