HGFAC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.82993920
2omega-hydroxylase P450 pathway (GO:0097267)7.66732627
3exogenous drug catabolic process (GO:0042738)7.61960366
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.55323918
5L-phenylalanine catabolic process (GO:0006559)7.55323918
6L-phenylalanine metabolic process (GO:0006558)7.21542638
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.21542638
8aromatic amino acid family catabolic process (GO:0009074)6.64761402
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.40367179
10regulation of plasminogen activation (GO:0010755)6.36344368
11tryptophan catabolic process (GO:0006569)5.88705098
12indole-containing compound catabolic process (GO:0042436)5.88705098
13indolalkylamine catabolic process (GO:0046218)5.88705098
14kynurenine metabolic process (GO:0070189)5.80377597
15bile acid biosynthetic process (GO:0006699)5.74399458
16glyoxylate metabolic process (GO:0046487)5.68304341
17high-density lipoprotein particle remodeling (GO:0034375)5.66150026
18negative regulation of fibrinolysis (GO:0051918)5.62908627
19tryptophan metabolic process (GO:0006568)5.56820717
20urea cycle (GO:0000050)5.52842527
21urea metabolic process (GO:0019627)5.52842527
22ethanol metabolic process (GO:0006067)5.46964728
23alpha-linolenic acid metabolic process (GO:0036109)5.46900892
24regulation of fibrinolysis (GO:0051917)5.44359580
25cysteine metabolic process (GO:0006534)5.41957134
26protein carboxylation (GO:0018214)5.37810322
27peptidyl-glutamic acid carboxylation (GO:0017187)5.37810322
28sulfur amino acid catabolic process (GO:0000098)5.36145121
29drug metabolic process (GO:0017144)5.24855249
30regulation of protein activation cascade (GO:2000257)5.20797596
31complement activation, alternative pathway (GO:0006957)5.16182758
32nitrogen cycle metabolic process (GO:0071941)5.09616528
33reverse cholesterol transport (GO:0043691)5.01036236
34serine family amino acid catabolic process (GO:0009071)4.99728469
35regulation of cholesterol esterification (GO:0010872)4.96489976
36bile acid metabolic process (GO:0008206)4.96459779
37regulation of triglyceride catabolic process (GO:0010896)4.92360569
38oxidative demethylation (GO:0070989)4.91298130
39opsonization (GO:0008228)4.83804948
40negative regulation of hemostasis (GO:1900047)4.83480949
41negative regulation of blood coagulation (GO:0030195)4.83480949
42plasma lipoprotein particle remodeling (GO:0034369)4.83342089
43protein-lipid complex remodeling (GO:0034368)4.83342089
44macromolecular complex remodeling (GO:0034367)4.83342089
45aromatic amino acid family metabolic process (GO:0009072)4.83275083
46regulation of complement activation (GO:0030449)4.82908333
47homocysteine metabolic process (GO:0050667)4.70816750
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.70363130
49negative regulation of protein activation cascade (GO:2000258)4.69316619
50phospholipid efflux (GO:0033700)4.69095406
51regulation of humoral immune response (GO:0002920)4.67713132
52tyrosine metabolic process (GO:0006570)4.67285137
53acylglycerol homeostasis (GO:0055090)4.62227010
54triglyceride homeostasis (GO:0070328)4.62227010
55negative regulation of sterol transport (GO:0032372)4.57819928
56negative regulation of cholesterol transport (GO:0032375)4.57819928
57alpha-amino acid catabolic process (GO:1901606)4.54639979
58positive regulation of hemostasis (GO:1900048)4.51188770
59positive regulation of blood coagulation (GO:0030194)4.51188770
60regulation of apoptotic cell clearance (GO:2000425)4.50913835
61amino-acid betaine metabolic process (GO:0006577)4.46730766
62cellular ketone body metabolic process (GO:0046950)4.43216566
63lysine metabolic process (GO:0006553)4.43082682
64lysine catabolic process (GO:0006554)4.43082682
65plasma lipoprotein particle clearance (GO:0034381)4.42636551
66negative regulation of coagulation (GO:0050819)4.39103868
67bile acid and bile salt transport (GO:0015721)4.36033958
68coenzyme catabolic process (GO:0009109)4.33414947
69glycine metabolic process (GO:0006544)4.31655173
70negative regulation of wound healing (GO:0061045)4.30526135
71S-adenosylmethionine metabolic process (GO:0046500)4.25945034
72positive regulation of fatty acid biosynthetic process (GO:0045723)4.25419004
73cholesterol efflux (GO:0033344)4.25406762
74imidazole-containing compound metabolic process (GO:0052803)4.22776036
75phenylpropanoid metabolic process (GO:0009698)4.21429749
76cellular amino acid catabolic process (GO:0009063)4.21097109
77indolalkylamine metabolic process (GO:0006586)4.20425253
78glutamate metabolic process (GO:0006536)4.18169887
79disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.13237162
80killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.13237162
81positive regulation of coagulation (GO:0050820)4.13149103
82cellular modified amino acid catabolic process (GO:0042219)4.11197922
83serine family amino acid metabolic process (GO:0009069)4.10820543
84amine catabolic process (GO:0009310)4.07824744
85cellular biogenic amine catabolic process (GO:0042402)4.07824744
86plasma lipoprotein particle assembly (GO:0034377)4.05846916
87cellular glucuronidation (GO:0052695)4.03867612
88protein-lipid complex subunit organization (GO:0071825)4.01250450
89fibrinolysis (GO:0042730)4.00901000
90benzene-containing compound metabolic process (GO:0042537)4.00240397
91blood coagulation, intrinsic pathway (GO:0007597)3.98343294
92low-density lipoprotein particle remodeling (GO:0034374)3.97440566
93intestinal cholesterol absorption (GO:0030299)3.97341923
94arginine metabolic process (GO:0006525)3.94376635
95serine family amino acid biosynthetic process (GO:0009070)3.94224019
96aldehyde catabolic process (GO:0046185)3.90063694
97negative regulation of complement activation (GO:0045916)3.89866161
98ethanol oxidation (GO:0006069)3.86389599
99positive regulation of lipoprotein lipase activity (GO:0051006)3.84000470
100positive regulation of triglyceride lipase activity (GO:0061365)3.84000470
101drug catabolic process (GO:0042737)3.83834154
102ketone body metabolic process (GO:1902224)3.83081964
103dicarboxylic acid biosynthetic process (GO:0043650)3.81924743
104positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.77570394
105cofactor catabolic process (GO:0051187)3.75516622
106cholesterol homeostasis (GO:0042632)3.75258798
107phospholipid homeostasis (GO:0055091)3.75156925
108positive regulation of lipid catabolic process (GO:0050996)3.73731868
109alkaloid metabolic process (GO:0009820)3.73375755
110negative regulation of lipase activity (GO:0060192)3.72138212
111sterol homeostasis (GO:0055092)3.69580530
112proline metabolic process (GO:0006560)3.68787811
113organic acid catabolic process (GO:0016054)3.68719457
114carboxylic acid catabolic process (GO:0046395)3.68719457
115regulation of bile acid biosynthetic process (GO:0070857)3.68673437
116protein activation cascade (GO:0072376)3.68653001
117plasma lipoprotein particle organization (GO:0071827)3.67698408
118regulation of cholesterol homeostasis (GO:2000188)3.67591858
119acute inflammatory response (GO:0002526)3.67440860
120very-low-density lipoprotein particle assembly (GO:0034379)3.64696905
121complement activation, classical pathway (GO:0006958)3.63922493
122short-chain fatty acid metabolic process (GO:0046459)3.63826727
123protein-lipid complex assembly (GO:0065005)3.62041999
124complement activation (GO:0006956)3.59534508
125uronic acid metabolic process (GO:0006063)3.57556890
126glucuronate metabolic process (GO:0019585)3.57556890
127acute-phase response (GO:0006953)3.54543805
128flavonoid metabolic process (GO:0009812)3.53118197
129lipoprotein metabolic process (GO:0042157)3.49885349
130cytolysis (GO:0019835)3.48457986

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.29049940
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.09994182
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.76812785
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.42265652
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.24471344
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.17453837
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.77029846
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.99485754
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.92270218
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.04609379
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9116351
12* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.98544252
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89843641
14GATA1_22025678_ChIP-Seq_K562_Human1.68139880
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.63208223
16CLOCK_20551151_ChIP-Seq_293T_Human1.50572935
17HTT_18923047_ChIP-ChIP_STHdh_Human1.48878662
18HNF4A_19822575_ChIP-Seq_HepG2_Human1.41707591
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36355209
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33821177
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31131438
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24294468
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17154060
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.16766836
25RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15668444
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.11735571
27* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11051190
28ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01911190
29DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00945502
30GATA4_25053715_ChIP-Seq_YYC3_Human0.98200087
31ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92817513
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90708187
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89895906
34CTCF_27219007_Chip-Seq_Bcells_Human0.87348390
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87088490
36* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85608691
37POU5F1_16518401_ChIP-PET_MESCs_Mouse0.84782639
38ESR2_21235772_ChIP-Seq_MCF-7_Human0.84278829
39* SMC4_20622854_ChIP-Seq_HELA_Human0.83548133
40SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83205710
41* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80251327
42RARA_24833708_ChIP-Seq_LIVER_Mouse0.79709209
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79109208
44AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76400002
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76370584
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.76361885
47* RAC3_21632823_ChIP-Seq_H3396_Human0.75895020
48SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75390922
49AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74875108
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.74581222
51KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74151960
52E2F1_20622854_ChIP-Seq_HELA_Human0.73932219
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73866168
54* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73460852
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.72495799
56ELF1_20517297_ChIP-Seq_JURKAT_Human0.72131198
57ESR1_21235772_ChIP-Seq_MCF-7_Human0.71401705
58DROSHA_22980978_ChIP-Seq_HELA_Human0.71400519
59SOX2_21211035_ChIP-Seq_LN229_Human0.70580020
60ZNF263_19887448_ChIP-Seq_K562_Human0.70000323
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69991541
62BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68703022
63EGR1_19032775_ChIP-ChIP_M12_Human0.68678365
64NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.66973813
65TCF4_18268006_ChIP-ChIP_LS174T_Human0.66549407
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.66453983
67RARB_24833708_ChIP-Seq_LIVER_Mouse0.65845364
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.65423156
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65355117
70FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64012633
71P68_20966046_ChIP-Seq_HELA_Human0.63524769
72GATA1_19941826_ChIP-Seq_K562_Human0.63137154
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63037235
74NFIB_24661679_ChIP-Seq_LUNG_Mouse0.62441797
75SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62126132
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61671604
77* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61418814
78NRF2_20460467_ChIP-Seq_MEFs_Mouse0.60727552
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.60727552
80FOXA1_25552417_ChIP-Seq_VCAP_Human0.59713626
81* LXR_22292898_ChIP-Seq_THP-1_Human0.58988019
82AR_20517297_ChIP-Seq_VCAP_Human0.58672063
83CEBPB_22108803_ChIP-Seq_LS180_Human0.58373052
84TET1_21451524_ChIP-Seq_MESCs_Mouse0.58224144
85SA1_27219007_Chip-Seq_Bcells_Human0.58024100
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.57820156
87GATA6_25053715_ChIP-Seq_YYC3_Human0.57464437
88TP63_17297297_ChIP-ChIP_HaCaT_Human0.56949630
89SRY_22984422_ChIP-ChIP_TESTIS_Rat0.56496880
90STAT3_1855785_ChIP-Seq_MESCs_Mouse0.55952339
91CTCF_20526341_ChIP-Seq_ESCs_Human0.55278193
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.55231540
93SPI1_20517297_ChIP-Seq_HL60_Human0.55188750
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.54980960
95OCT4_20526341_ChIP-Seq_ESCs_Human0.54622880
96P53_21459846_ChIP-Seq_SAOS-2_Human0.54399662
97BCL6_27268052_Chip-Seq_Bcells_Human0.54174192
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.53892832
99CDX2_20551321_ChIP-Seq_CACO-2_Human0.53716059
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.53378693
101PHF8_20622854_ChIP-Seq_HELA_Human0.53370681
102* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.53084870
103FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52788124
104* MYC_19829295_ChIP-Seq_ESCs_Human0.52633415
105ESET_19884257_ChIP-Seq_ESCs_Mouse0.52028210
106JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.51906716
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.51887654
108* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51695539
109ESR1_20079471_ChIP-ChIP_T-47D_Human0.51337562
110GATA2_19941826_ChIP-Seq_K562_Human0.50537792
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.50524804
112MYC_19915707_ChIP-ChIP_AK7_Human0.50276198
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.49894682
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.49379208
115* GATA1_19941827_ChIP-Seq_MEL_Mouse0.49073273
116SOX2_20726797_ChIP-Seq_SW620_Human0.47371987
117CBP_21632823_ChIP-Seq_H3396_Human0.46990912
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45644213
119* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.44924680
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44092444
121STAT1_17558387_ChIP-Seq_HELA_Human0.43178152
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.42294064
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.42057457
124TAF2_19829295_ChIP-Seq_ESCs_Human0.42012116
125ERG_20517297_ChIP-Seq_VCAP_Human0.41750821
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.40041010
127STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39284810
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.38925876
129PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.38428239
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.37407341
131SPI1_26923725_Chip-Seq_HPCs_Mouse0.37339610
132BCOR_27268052_Chip-Seq_Bcells_Human0.37092768
133FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.37006925
134MYC_27129775_Chip-Seq_CORNEA_Mouse0.36504147
135GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.35882220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.05727596
2MP0005360_urolithiasis7.25992564
3MP0005085_abnormal_gallbladder_physiolo6.41782971
4MP0005365_abnormal_bile_salt6.28313351
5MP0008875_abnormal_xenobiotic_pharmacok4.93688763
6MP0003806_abnormal_nucleotide_metabolis4.14893411
7MP0003252_abnormal_bile_duct3.78061869
8MP0010329_abnormal_lipoprotein_level3.58800852
9MP0005083_abnormal_biliary_tract3.50884033
10MP0009840_abnormal_foam_cell3.27747055
11MP0001666_abnormal_nutrient_absorption2.99581312
12MP0003195_calcinosis2.86877012
13MP0005332_abnormal_amino_acid2.73849295
14MP0003191_abnormal_cellular_cholesterol2.37223938
15MP0003868_abnormal_feces_composition2.19283810
16MP0000609_abnormal_liver_physiology2.13536016
17MP0002118_abnormal_lipid_homeostasis2.12699128
18MP0004019_abnormal_vitamin_homeostasis2.07815166
19MP0002138_abnormal_hepatobiliary_system2.04137975
20MP0009697_abnormal_copulation1.89321312
21MP0005319_abnormal_enzyme/_coenzyme1.77687286
22MP0001764_abnormal_homeostasis1.71450407
23MP0000566_synostosis1.52696681
24MP0005584_abnormal_enzyme/coenzyme_acti1.48840232
25MP0005451_abnormal_body_composition1.37372681
26MP0009643_abnormal_urine_homeostasis1.29626622
27MP0002132_abnormal_respiratory_system1.28311197
28MP0003011_delayed_dark_adaptation1.26898655
29MP0003656_abnormal_erythrocyte_physiolo1.25465221
30MP0003186_abnormal_redox_activity1.20702064
31MP0000598_abnormal_liver_morphology1.19707601
32MP0003122_maternal_imprinting1.17484996
33MP0003705_abnormal_hypodermis_morpholog1.15699854
34MP0005220_abnormal_exocrine_pancreas1.13975859
35MP0001915_intracranial_hemorrhage1.10482113
36MP0005647_abnormal_sex_gland1.05050986
37MP0000604_amyloidosis1.04138531
38MP0002254_reproductive_system_inflammat1.03762413
39MP0005084_abnormal_gallbladder_morpholo1.03710069
40MP0002282_abnormal_trachea_morphology1.03207309
41MP0002249_abnormal_larynx_morphology1.01183132
42MP0009764_decreased_sensitivity_to0.98421313
43* MP0009763_increased_sensitivity_to0.97973097
44MP0003879_abnormal_hair_cell0.97957660
45MP0005636_abnormal_mineral_homeostasis0.97513218
46MP0010368_abnormal_lymphatic_system0.91751434
47MP0005408_hypopigmentation0.90753689
48MP0009642_abnormal_blood_homeostasis0.90190499
49MP0008469_abnormal_protein_level0.90120649
50MP0002078_abnormal_glucose_homeostasis0.88159065
51MP0002876_abnormal_thyroid_physiology0.82447920
52MP0006036_abnormal_mitochondrial_physio0.80933011
53MP0006292_abnormal_olfactory_placode0.79917536
54MP0002089_abnormal_postnatal_growth/wei0.78086678
55MP0005376_homeostasis/metabolism_phenot0.77513460
56MP0005670_abnormal_white_adipose0.73739773
57MP0003172_abnormal_lysosome_physiology0.73200018
58MP0005464_abnormal_platelet_physiology0.73109905
59MP0005334_abnormal_fat_pad0.72480495
60MP0002971_abnormal_brown_adipose0.70435058
61* MP0009765_abnormal_xenobiotic_induced0.69402140
62MP0005535_abnormal_body_temperature0.68630269
63MP0005448_abnormal_energy_balance0.64925986
64MP0004130_abnormal_muscle_cell0.63514404
65MP0000639_abnormal_adrenal_gland0.63285365
66MP0001756_abnormal_urination0.61025861
67MP0001661_extended_life_span0.59629660
68MP0005266_abnormal_metabolism0.58241477
69MP0003878_abnormal_ear_physiology0.55543519
70MP0005377_hearing/vestibular/ear_phenot0.55543519
71MP0003329_amyloid_beta_deposits0.55057456
72MP0003690_abnormal_glial_cell0.54601415
73MP0003638_abnormal_response/metabolism_0.54436942
74MP0002928_abnormal_bile_duct0.53429086
75MP0009053_abnormal_anal_canal0.50850841
76MP0005187_abnormal_penis_morphology0.50232990
77MP0003953_abnormal_hormone_level0.49231373
78MP0004264_abnormal_extraembryonic_tissu0.48403007
79MP0003436_decreased_susceptibility_to0.48136440
80MP0002136_abnormal_kidney_physiology0.44866616
81MP0006035_abnormal_mitochondrial_morpho0.44473156
82MP0002837_dystrophic_cardiac_calcinosis0.43870888
83MP0003075_altered_response_to0.43793578
84MP0004782_abnormal_surfactant_physiolog0.43238925
85MP0005409_darkened_coat_color0.43148974
86MP0002909_abnormal_adrenal_gland0.42448437
87MP0005395_other_phenotype0.42415405
88MP0008873_increased_physiological_sensi0.41709539
89MP0008872_abnormal_physiological_respon0.41701368
90MP0000678_abnormal_parathyroid_gland0.41661315
91MP0003724_increased_susceptibility_to0.41500319
92MP0001944_abnormal_pancreas_morphology0.41198551
93MP0002822_catalepsy0.39724794
94MP0008874_decreased_physiological_sensi0.39236042
95MP0005166_decreased_susceptibility_to0.38482764
96MP0000249_abnormal_blood_vessel0.37831568
97MP0000467_abnormal_esophagus_morphology0.37608283
98MP0002796_impaired_skin_barrier0.35985783
99MP0003959_abnormal_lean_body0.35785646
100MP0009785_altered_susceptibility_to0.35609678
101MP0001845_abnormal_inflammatory_respons0.35257160
102MP0005023_abnormal_wound_healing0.34776502
103MP0005248_abnormal_Harderian_gland0.34602815
104MP0004883_abnormal_blood_vessel0.33970653
105MP0003718_maternal_effect0.33543528
106MP0005164_abnormal_response_to0.33274589
107MP0005167_abnormal_blood-brain_barrier0.32981858
108MP0002970_abnormal_white_adipose0.32822903
109MP0000230_abnormal_systemic_arterial0.32607188
110MP0005666_abnormal_adipose_tissue0.32306082
111MP0009115_abnormal_fat_cell0.31735667
112MP0003115_abnormal_respiratory_system0.31513322
113MP0006082_CNS_inflammation0.31377213
114MP0005058_abnormal_lysosome_morphology0.31023582
115MP0009672_abnormal_birth_weight0.30915607
116MP0001243_abnormal_dermal_layer0.30828913
117MP0000579_abnormal_nail_morphology0.29180313
118MP0002693_abnormal_pancreas_physiology0.29138572
119MP0009780_abnormal_chondrocyte_physiolo0.28906384
120MP0002168_other_aberrant_phenotype0.28001470
121MP0009384_cardiac_valve_regurgitation0.27749476
122MP0002234_abnormal_pharynx_morphology0.27145521
123MP0001765_abnormal_ion_homeostasis0.26922244
124MP0002092_abnormal_eye_morphology0.21925541
125MP0004272_abnormal_basement_membrane0.21896881
126MP0003632_abnormal_nervous_system0.21002875

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.54993426
2Deep venous thrombosis (HP:0002625)7.30539189
3Intrahepatic cholestasis (HP:0001406)7.11958193
4Prolonged partial thromboplastin time (HP:0003645)6.53030381
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.50868607
6Hypobetalipoproteinemia (HP:0003563)6.16706573
7Xanthomatosis (HP:0000991)6.10389145
8Hyperlipoproteinemia (HP:0010980)5.38786675
9Complement deficiency (HP:0004431)5.08983499
10Joint hemorrhage (HP:0005261)4.98023363
11Abnormality of the common coagulation pathway (HP:0010990)4.79007476
12Hypolipoproteinemia (HP:0010981)4.69693160
13Hyperammonemia (HP:0001987)4.44079246
14Ketosis (HP:0001946)4.35406489
15Abnormality of the intrinsic pathway (HP:0010989)4.33493584
16Hyperglycinemia (HP:0002154)4.29439073
17Epidermoid cyst (HP:0200040)4.27621933
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.25887439
19Fat malabsorption (HP:0002630)4.22501454
20Hypoalphalipoproteinemia (HP:0003233)4.18237121
21Abnormality of methionine metabolism (HP:0010901)4.14901806
22Abnormality of sulfur amino acid metabolism (HP:0004339)4.13046519
23Hypoglycemic coma (HP:0001325)4.12205067
24Abnormality of glutamine family amino acid metabolism (HP:0010902)4.01379024
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.98337691
26Hyperglycinuria (HP:0003108)3.81039562
27Conjugated hyperbilirubinemia (HP:0002908)3.80480557
28Abnormality of serine family amino acid metabolism (HP:0010894)3.79500743
29Abnormality of glycine metabolism (HP:0010895)3.79500743
30Abnormality of complement system (HP:0005339)3.69827430
31Abnormality of pyrimidine metabolism (HP:0004353)3.59462584
32Hypercholesterolemia (HP:0003124)3.45788357
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.43025665
34Hyperbilirubinemia (HP:0002904)3.40363804
35Abnormality of fatty-acid metabolism (HP:0004359)3.32561339
36Steatorrhea (HP:0002570)3.23747507
37Ketoacidosis (HP:0001993)3.17659129
38Spontaneous abortion (HP:0005268)3.10360303
39Abnormality of nucleobase metabolism (HP:0010932)2.98101683
40Purpura (HP:0000979)2.96262522
41Myocardial infarction (HP:0001658)2.95193091
42Delayed CNS myelination (HP:0002188)2.94458412
43Abnormality of serum amino acid levels (HP:0003112)2.89015035
44Hepatocellular carcinoma (HP:0001402)2.87693429
45Hypoglycemic seizures (HP:0002173)2.80853987
46Hypochromic microcytic anemia (HP:0004840)2.80132554
47Metabolic acidosis (HP:0001942)2.75831114
48Skin nodule (HP:0200036)2.72265664
49Abnormality of purine metabolism (HP:0004352)2.67421232
50Systemic lupus erythematosus (HP:0002725)2.66018959
51Gout (HP:0001997)2.62382326
52Dicarboxylic aciduria (HP:0003215)2.56907648
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56907648
54Menorrhagia (HP:0000132)2.54472299
55Acanthocytosis (HP:0001927)2.54237260
56Lethargy (HP:0001254)2.53067976
57Vascular calcification (HP:0004934)2.52530211
58Fair hair (HP:0002286)2.50523121
59Abnormal gallbladder morphology (HP:0012437)2.46212646
60Gingival bleeding (HP:0000225)2.44567232
61Glomerulonephritis (HP:0000099)2.43835721
62Irritability (HP:0000737)2.38015157
63Pulmonary embolism (HP:0002204)2.37502794
64Amyloidosis (HP:0011034)2.37123774
65Late onset (HP:0003584)2.34467073
66Cholelithiasis (HP:0001081)2.34420119
67Mitral stenosis (HP:0001718)2.32923658
68Hyperinsulinemic hypoglycemia (HP:0000825)2.32001821
69Neonatal hypoglycemia (HP:0001998)2.31095619
70Cerebral edema (HP:0002181)2.30458817
71Esophageal varix (HP:0002040)2.29959994
72Pancreatitis (HP:0001733)2.28645521
73Spastic diplegia (HP:0001264)2.28019877
74Brushfield spots (HP:0001088)2.24905827
75Cholecystitis (HP:0001082)2.24067546
76Abnormal gallbladder physiology (HP:0012438)2.24067546
77Recurrent gram-negative bacterial infections (HP:0005420)2.23845003
78Cardiovascular calcification (HP:0011915)2.22379386
79Malnutrition (HP:0004395)2.20424643
80Neonatal onset (HP:0003623)2.19956892
81Generalized aminoaciduria (HP:0002909)2.19112908
82Thrombophlebitis (HP:0004418)2.14562585
83Osteomalacia (HP:0002749)2.14539150
84Enlarged kidneys (HP:0000105)2.07689775
85Arthropathy (HP:0003040)2.07649171
86Hemorrhage of the eye (HP:0011885)2.05034739
87Bifid scrotum (HP:0000048)2.03338836
88Vomiting (HP:0002013)2.02757367
89Sensorimotor neuropathy (HP:0007141)2.02298030
90Poikilocytosis (HP:0004447)2.02183155
91Opisthotonus (HP:0002179)1.99108180
92Hyperglycemia (HP:0003074)1.98669723
93Abnormality of the gallbladder (HP:0005264)1.97086983
94Symptomatic seizures (HP:0011145)1.92195353
95Abnormality of the Achilles tendon (HP:0005109)1.89485672
96Rickets (HP:0002748)1.88654896
97Renal cortical cysts (HP:0000803)1.88316533
98Abnormal cartilage morphology (HP:0002763)1.88121152
99Gangrene (HP:0100758)1.86919570
100Elevated hepatic transaminases (HP:0002910)1.84402932
101Abnormality of transition element cation homeostasis (HP:0011030)1.83883609
102Alkalosis (HP:0001948)1.83042555
103Abnormality of proline metabolism (HP:0010907)1.82733650
104Hydroxyprolinuria (HP:0003080)1.82733650
105Reticulocytosis (HP:0001923)1.82352942
106Abnormality of iron homeostasis (HP:0011031)1.82074715
107Hypophosphatemic rickets (HP:0004912)1.81755131
108Epistaxis (HP:0000421)1.78980767
109Acute hepatic failure (HP:0006554)1.78726387
110Abnormal enzyme/coenzyme activity (HP:0012379)1.77418840
111Nephritis (HP:0000123)1.74112854
112Blue irides (HP:0000635)1.68955854
113Increased serum ferritin (HP:0003281)1.66506963
114Generalized hypopigmentation of hair (HP:0011358)1.64969391
115Increased mean platelet volume (HP:0011877)1.63350664
116Joint swelling (HP:0001386)1.61043223
117Elevated alkaline phosphatase (HP:0003155)1.58306989
118Increased serum pyruvate (HP:0003542)1.52171515
119Abnormality of alkaline phosphatase activity (HP:0004379)1.51378257
120Megaloblastic anemia (HP:0001889)1.50491749
121Potter facies (HP:0002009)1.49566367
122Facial shape deformation (HP:0011334)1.49566367
123Abnormal platelet function (HP:0011869)1.47371951
124Impaired platelet aggregation (HP:0003540)1.47371951
125Hyperphosphaturia (HP:0003109)1.46681812
126Hypochromic anemia (HP:0001931)1.44623316
127Abnormal platelet volume (HP:0011876)1.44478756
128Abnormal delivery (HP:0001787)1.35186477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.18150531
2ERN14.63573717
3FGFR44.24219738
4SIK14.03514453
5INSRR3.44852521
6TAOK33.36133935
7PIK3CG3.01476161
8ERBB42.41275670
9FLT32.40336355
10NTRK32.39410788
11PKN22.28229814
12WNK42.23567395
13MST1R2.00998215
14TRIB31.92376062
15MAPK111.89199190
16MAP2K41.87954761
17FRK1.76407108
18PTK61.72965635
19MAPK151.57290266
20TYK21.55453300
21TYRO31.53263585
22SIK21.51428499
23PDGFRA1.51018064
24NEK91.48882047
25EPHA41.43809264
26CDK121.39206252
27MAP3K71.29121037
28DAPK21.23002522
29LATS11.20974739
30JAK21.20093856
31KDR1.19974306
32FGFR11.15934524
33ABL21.10890158
34DDR21.05704681
35MAP3K141.04549874
36EPHA31.03944909
37TBK11.02886720
38MAP2K30.99886388
39SGK2230.99814168
40SGK4940.99814168
41TGFBR20.99231906
42MAP3K100.97483358
43PRKAA20.95468745
44EPHB10.95161526
45PIK3CA0.95142649
46PRKG20.95050812
47GRK60.89688726
48JAK10.88084323
49AKT30.85076150
50MAP2K20.84866370
51MAPK40.83320592
52MAP2K60.83177667
53TIE10.83135161
54MET0.82699929
55CDK60.81429382
56FGFR20.81216067
57PINK10.80422348
58ERBB20.79555900
59DYRK1B0.73884809
60IRAK30.72943485
61MAP3K30.72577293
62PRKCZ0.70955135
63SGK10.70841288
64PRKACG0.69133845
65CSK0.68885930
66SGK30.68366943
67PTK20.67296765
68MARK20.67046994
69MAP3K110.66134000
70WNK10.66102307
71FGFR30.65829394
72EPHA20.64732286
73MAPK120.64203245
74PRKG10.62770920
75IKBKE0.61497077
76SMG10.61288471
77KIT0.61257867
78PDPK10.57771808
79FGR0.57007504
80CSNK1E0.56498173
81GSK3A0.55356881
82IGF1R0.55326909
83PRKAA10.54934363
84PRKACA0.53849166
85BCR0.53456902
86CAMK2G0.53421909
87NTRK20.53234319
88CSNK1D0.52909908
89RET0.52566949
90EEF2K0.50525193
91MAP2K10.50259664
92SRC0.50105864
93CDK40.49776133
94FER0.49763165
95CAMKK10.48931327
96DYRK1A0.48909295
97ZAP700.48880520
98CAMK40.48795690
99STK38L0.48465823
100CDC42BPA0.48141188
101MAP3K130.48074481
102TNK20.47084693
103MAPK70.46639243
104RPS6KA30.45796553
105MAP3K10.44718246
106PRPF4B0.44629406
107RIPK10.43854197
108PDGFRB0.40501224
109MTOR0.40405371
110PDK10.40027349
111MAP4K10.38115148
112CAMK1D0.37104784
113PRKCQ0.36658635
114CSF1R0.36500038
115RPS6KB10.34806875
116GRK10.33781450
117MAPKAPK30.31165489
118MAPK100.30606665
119CDK70.29533860
120PDK20.28119816
121MAPK80.27551719
122PRKCB0.27236016
123MAPK10.27149051
124CSNK2A10.27094734
125IRAK10.26393845
126ICK0.25035112
127EGFR0.24291732
128PRKCA0.24193573
129PRKACB0.24171740
130MAPK30.24167354
131MAP3K20.23608363
132CSNK1G10.22668603
133MATK0.21564176
134TAOK20.21507515
135SGK20.21371775
136BTK0.21213209
137STK380.21182899
138MAP3K50.19734061
139CHUK0.19324585
140IKBKB0.19206323
141JAK30.18493437
142MAP3K60.17002805
143PRKCG0.16553093
144STK30.16051260

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.43377232
2Nitrogen metabolism_Homo sapiens_hsa009103.51550536
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34749772
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26007448
5Arginine biosynthesis_Homo sapiens_hsa002203.05155183
6Complement and coagulation cascades_Homo sapiens_hsa046102.80392859
7Tryptophan metabolism_Homo sapiens_hsa003802.68412360
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62472609
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60690362
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58973488
11Fatty acid degradation_Homo sapiens_hsa000712.47158697
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40951224
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25477880
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11572331
15Butanoate metabolism_Homo sapiens_hsa006502.10762910
16Peroxisome_Homo sapiens_hsa041462.04815762
17Histidine metabolism_Homo sapiens_hsa003401.95721679
18Chemical carcinogenesis_Homo sapiens_hsa052041.92955811
19Propanoate metabolism_Homo sapiens_hsa006401.91188924
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89184457
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.85486577
22PPAR signaling pathway_Homo sapiens_hsa033201.83062366
23Fatty acid metabolism_Homo sapiens_hsa012121.76037050
24Staphylococcus aureus infection_Homo sapiens_hsa051501.75603267
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.72036846
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68223100
27beta-Alanine metabolism_Homo sapiens_hsa004101.67520425
28Caffeine metabolism_Homo sapiens_hsa002321.66257639
29Selenocompound metabolism_Homo sapiens_hsa004501.62206180
30Retinol metabolism_Homo sapiens_hsa008301.61316883
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60447046
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58203878
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56726143
34Phenylalanine metabolism_Homo sapiens_hsa003601.54290039
35Sulfur metabolism_Homo sapiens_hsa009201.53447660
36Bile secretion_Homo sapiens_hsa049761.47617336
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46204458
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.45510133
39Fat digestion and absorption_Homo sapiens_hsa049751.43782810
40Folate biosynthesis_Homo sapiens_hsa007901.39646947
41Tyrosine metabolism_Homo sapiens_hsa003501.39474715
42Pyruvate metabolism_Homo sapiens_hsa006201.33159555
43Starch and sucrose metabolism_Homo sapiens_hsa005001.30469327
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.29066197
45Fatty acid elongation_Homo sapiens_hsa000621.25877400
46Steroid biosynthesis_Homo sapiens_hsa001001.23839361
47ABC transporters_Homo sapiens_hsa020101.20445083
48Biosynthesis of amino acids_Homo sapiens_hsa012301.16563839
49Carbon metabolism_Homo sapiens_hsa012001.06298417
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.03164221
51Arginine and proline metabolism_Homo sapiens_hsa003301.00886865
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00538894
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96012299
54Vitamin digestion and absorption_Homo sapiens_hsa049770.94073129
55Sulfur relay system_Homo sapiens_hsa041220.92039526
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85474040
57Vitamin B6 metabolism_Homo sapiens_hsa007500.83541296
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80512237
59Lysine degradation_Homo sapiens_hsa003100.78581502
60Glycerolipid metabolism_Homo sapiens_hsa005610.77590757
61One carbon pool by folate_Homo sapiens_hsa006700.74291437
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66800653
63Glutathione metabolism_Homo sapiens_hsa004800.66432410
64Pentose phosphate pathway_Homo sapiens_hsa000300.54606610
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50583848
66Metabolic pathways_Homo sapiens_hsa011000.46540333
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45530775
68Pertussis_Homo sapiens_hsa051330.45412073
69Fatty acid biosynthesis_Homo sapiens_hsa000610.42756788
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36346548
71Galactose metabolism_Homo sapiens_hsa000520.34867061
72Linoleic acid metabolism_Homo sapiens_hsa005910.31216369
73Prion diseases_Homo sapiens_hsa050200.30634848
74Fructose and mannose metabolism_Homo sapiens_hsa000510.30223814
75Insulin resistance_Homo sapiens_hsa049310.26896796
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.21844252
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.18263668
78Mineral absorption_Homo sapiens_hsa049780.13739989
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11873262
80Glucagon signaling pathway_Homo sapiens_hsa049220.10811462
81AMPK signaling pathway_Homo sapiens_hsa041520.02431675
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01509957
83Amoebiasis_Homo sapiens_hsa051460.00210361
84FoxO signaling pathway_Homo sapiens_hsa04068-0.2194125
85Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.2192163
86Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2095646
87Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2059375
88Type II diabetes mellitus_Homo sapiens_hsa04930-0.1974018
89Other glycan degradation_Homo sapiens_hsa00511-0.1859214
90Hepatitis C_Homo sapiens_hsa05160-0.1812467
91Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1699894
92N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1547123
93African trypanosomiasis_Homo sapiens_hsa05143-0.1454612
94Serotonergic synapse_Homo sapiens_hsa04726-0.1450706
95Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1424126
96Pancreatic secretion_Homo sapiens_hsa04972-0.1371852
97Regulation of autophagy_Homo sapiens_hsa04140-0.1318913
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1111346
99Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1093140
100Insulin signaling pathway_Homo sapiens_hsa04910-0.1072215
101Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1024334
102Circadian rhythm_Homo sapiens_hsa04710-0.0994347
103Protein digestion and absorption_Homo sapiens_hsa04974-0.0915935
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0842289
105Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0766454
106Renin-angiotensin system_Homo sapiens_hsa04614-0.0691225
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0660324
108Sphingolipid metabolism_Homo sapiens_hsa00600-0.0394854
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0315761
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0122928

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »