HEXB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)9.38697111
2regulation of chemokine secretion (GO:0090196)8.15970643
3macrophage activation involved in immune response (GO:0002281)7.69234951
4regulation of interferon-beta biosynthetic process (GO:0045357)7.07712604
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.69238539
6positive regulation by organism of defense response of other organism involved in symbiotic interact6.69238539
7modulation by symbiont of host immune response (GO:0052553)6.69238539
8positive regulation by symbiont of host defense response (GO:0052509)6.69238539
9modulation by symbiont of host defense response (GO:0052031)6.69238539
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.69238539
11negative regulation of granulocyte differentiation (GO:0030853)6.56548258
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.49835239
13G-protein coupled purinergic receptor signaling pathway (GO:0035588)6.35002977
14purinergic nucleotide receptor signaling pathway (GO:0035590)6.07912358
15macrophage activation (GO:0042116)6.00359256
16regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.69298958
17adenosine receptor signaling pathway (GO:0001973)5.24758555
18purinergic receptor signaling pathway (GO:0035587)4.91062199
19monocyte differentiation (GO:0030224)4.64354367
20positive regulation of interferon-alpha production (GO:0032727)4.52657711
21regulation of B cell receptor signaling pathway (GO:0050855)4.50537661
22* glycosphingolipid catabolic process (GO:0046479)4.46058542
23cellular response to thyroid hormone stimulus (GO:0097067)4.36053156
24I-kappaB phosphorylation (GO:0007252)4.31070968
25mannose metabolic process (GO:0006013)4.26869565
26regulation of interferon-alpha production (GO:0032647)4.26866541
27response to host (GO:0075136)4.16565318
28response to host defenses (GO:0052200)4.16565318
29response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.16565318
30macrophage differentiation (GO:0030225)4.16070437
31amino sugar catabolic process (GO:0046348)4.10035583
32negative regulation of tissue remodeling (GO:0034104)4.07064557
33negative regulation of norepinephrine secretion (GO:0010700)4.06519982
34ruffle organization (GO:0031529)4.04682729
35* glycolipid catabolic process (GO:0019377)4.02235444
36myeloid cell activation involved in immune response (GO:0002275)3.99323485
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.98981431
38response to host immune response (GO:0052572)3.98981431
39positive regulation of B cell differentiation (GO:0045579)3.98706177
40response to thyroid hormone (GO:0097066)3.96070465
41positive regulation of antigen processing and presentation (GO:0002579)3.95800613
42pathway-restricted SMAD protein phosphorylation (GO:0060389)3.91366660
43barbed-end actin filament capping (GO:0051016)3.88821863
44cell-cell junction maintenance (GO:0045217)3.86767494
45positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.82766944
46germ cell migration (GO:0008354)3.80648925
47negative regulation of interleukin-6 production (GO:0032715)3.78776415
48regulation of mononuclear cell migration (GO:0071675)3.77240168
49positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.75278159
50negative regulation of interleukin-12 production (GO:0032695)3.73336415
51negative regulation of bone resorption (GO:0045779)3.73295156
52positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.73172270
53pinocytosis (GO:0006907)3.71290132
54* oligosaccharide catabolic process (GO:0009313)3.70533226
55sodium-independent organic anion transport (GO:0043252)3.70152718
56adaptation of signaling pathway (GO:0023058)3.68640224
57protein localization to endosome (GO:0036010)3.62501046
58macrophage chemotaxis (GO:0048246)3.57329114
59negative regulation of multicellular organism growth (GO:0040015)3.53964295
60regulation of macrophage chemotaxis (GO:0010758)3.51409084
61positive regulation of leukocyte degranulation (GO:0043302)3.51128640
62response to cholesterol (GO:0070723)3.49638342
63negative regulation of systemic arterial blood pressure (GO:0003085)3.38879834
64apoptotic cell clearance (GO:0043277)3.38662115
65* ceramide catabolic process (GO:0046514)3.37250570
66positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.37180814
67negative regulation of macrophage differentiation (GO:0045650)3.35661643
68cyclooxygenase pathway (GO:0019371)3.35264926
69phagocytosis, engulfment (GO:0006911)3.34897064
70negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.32902464
71negative regulation of cell killing (GO:0031342)3.32902464
72positive regulation of monocyte chemotaxis (GO:0090026)3.32672428
73cellular extravasation (GO:0045123)3.31837268
74regulation of cholesterol storage (GO:0010885)3.28703671
75regulation of monocyte differentiation (GO:0045655)3.28290305
76peptide catabolic process (GO:0043171)3.27108400
77response to laminar fluid shear stress (GO:0034616)3.23386688
78negative regulation of nitric oxide biosynthetic process (GO:0045019)3.22678087
79regulation of antigen processing and presentation (GO:0002577)3.16223575
80regulation of chemokine-mediated signaling pathway (GO:0070099)3.16086247
81tolerance induction (GO:0002507)3.15198088
82* membrane lipid catabolic process (GO:0046466)3.14214760
83virion attachment to host cell (GO:0019062)3.14028377
84adhesion of symbiont to host cell (GO:0044650)3.14028377
85detection of molecule of bacterial origin (GO:0032490)3.13679715
86positive regulation of interferon-beta production (GO:0032728)3.13555405
87response to muramyl dipeptide (GO:0032495)3.12898538
88regulation of granulocyte differentiation (GO:0030852)3.11798367
89myeloid leukocyte activation (GO:0002274)3.08403189
90positive regulation of chemokine production (GO:0032722)3.08071928
91respiratory burst (GO:0045730)3.06213161
92positive regulation of SMAD protein import into nucleus (GO:0060391)3.01891117
93* sphingolipid catabolic process (GO:0030149)3.01488403
94regulation of actin cytoskeleton reorganization (GO:2000249)3.01218484
95negative regulation of B cell proliferation (GO:0030889)3.00974170
96positive regulation of cellular amide metabolic process (GO:0034250)2.99968721
97receptor catabolic process (GO:0032801)2.99382313
98COPI coating of Golgi vesicle (GO:0048205)2.98062400
99Golgi transport vesicle coating (GO:0048200)2.98062400
100cell junction maintenance (GO:0034331)2.97917285
101adhesion of symbiont to host (GO:0044406)2.96673251
102regulation of monocyte chemotaxis (GO:0090025)2.96447140
103negative regulation of bone remodeling (GO:0046851)2.96031719
104N-acetylneuraminate metabolic process (GO:0006054)2.96002457
105regulation of membrane protein ectodomain proteolysis (GO:0051043)2.95545620
106cell adhesion mediated by integrin (GO:0033627)2.94554411
107regulation of bone resorption (GO:0045124)2.90695800
108immunoglobulin mediated immune response (GO:0016064)2.89923956
109response to sterol (GO:0036314)2.89516391
110regulation of leukocyte degranulation (GO:0043300)2.88238663
111regulation of superoxide anion generation (GO:0032928)2.86701407
112response to peptidoglycan (GO:0032494)2.81509312
113regulation of mast cell degranulation (GO:0043304)2.80664760
114regulation of T cell tolerance induction (GO:0002664)2.80358467
115regulation of interferon-gamma biosynthetic process (GO:0045072)2.79490145
116regulation of extracellular matrix disassembly (GO:0010715)2.79403598
117response to acidic pH (GO:0010447)2.77511448
118positive regulation of chemokine biosynthetic process (GO:0045080)2.77359421
119neutrophil activation involved in immune response (GO:0002283)2.76599304
120cellular response to interleukin-6 (GO:0071354)2.76228116
121regulation of B cell differentiation (GO:0045577)2.74933135
122regulation of vitamin D biosynthetic process (GO:0060556)2.74110607
123positive regulation of erythrocyte differentiation (GO:0045648)2.73790824
124regulation of erythrocyte differentiation (GO:0045646)2.73160622
125T-helper 1 type immune response (GO:0042088)2.72153239
126lipopolysaccharide-mediated signaling pathway (GO:0031663)2.70284064
127low-density lipoprotein particle clearance (GO:0034383)2.67840515
128fat-soluble vitamin biosynthetic process (GO:0042362)2.65935425
129cellular response to arsenic-containing substance (GO:0071243)2.64927709
130positive regulation of toll-like receptor signaling pathway (GO:0034123)2.64788304
131angiotensin maturation (GO:0002003)2.63445771
132positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.63140392
133detection of external biotic stimulus (GO:0098581)2.62917294
134histamine secretion (GO:0001821)2.62634810
135negative regulation of smooth muscle contraction (GO:0045986)2.62404328
136positive regulation of mast cell activation involved in immune response (GO:0033008)2.62403962
137positive regulation of mast cell degranulation (GO:0043306)2.62403962
138myeloid dendritic cell differentiation (GO:0043011)2.62021105
139vitamin D metabolic process (GO:0042359)2.60920299
140detection of other organism (GO:0098543)2.60425536
141dendritic cell differentiation (GO:0097028)2.58827437
142positive regulation of cholesterol efflux (GO:0010875)2.58461352
143B cell receptor signaling pathway (GO:0050853)2.56741357
144cortical actin cytoskeleton organization (GO:0030866)2.55330428
145negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.55091526
146iron ion import (GO:0097286)2.54631316
147positive regulation of extracellular matrix organization (GO:1903055)2.53438661
148membrane raft organization (GO:0031579)2.52382213
149* lysosome organization (GO:0007040)2.52074036
150* lytic vacuole organization (GO:0080171)2.52074036
151regulation of interleukin-8 biosynthetic process (GO:0045414)2.51996495
152regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.51991951
153regulation of mast cell activation involved in immune response (GO:0033006)2.50373494
154regulation of early endosome to late endosome transport (GO:2000641)2.50275664
155regulation of vitamin metabolic process (GO:0030656)2.49400697
156decidualization (GO:0046697)2.49048207
157regulation of podosome assembly (GO:0071801)2.48020107
158regulation of chemokine biosynthetic process (GO:0045073)2.47801929
159regulation of myeloid leukocyte mediated immunity (GO:0002886)2.46004304
160negative regulation of protein localization to plasma membrane (GO:1903077)2.45881678
161skin morphogenesis (GO:0043589)2.45371446
162phagosome maturation (GO:0090382)2.43106619
163eosinophil chemotaxis (GO:0048245)2.42332055
164positive regulation of mast cell activation (GO:0033005)2.41670984
165amyloid precursor protein catabolic process (GO:0042987)2.40677984
166osteoclast differentiation (GO:0030316)2.40152936
167regulation of cytokine secretion involved in immune response (GO:0002739)2.38705961
168* keratan sulfate catabolic process (GO:0042340)2.36372423
169maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.36215810
170phospholipid efflux (GO:0033700)2.35758516
171sphingosine metabolic process (GO:0006670)2.35540457
172protein retention in ER lumen (GO:0006621)2.34731440
173plasma lipoprotein particle clearance (GO:0034381)2.33061482
174positive regulation of cholesterol transport (GO:0032376)2.32862582
175positive regulation of sterol transport (GO:0032373)2.32862582
176negative regulation of myeloid cell apoptotic process (GO:0033033)2.32724391
177granulocyte activation (GO:0036230)2.31992451
178positive regulation of interleukin-6 production (GO:0032755)2.29823130
179regulation of cholesterol esterification (GO:0010872)2.29391216
180* hyaluronan catabolic process (GO:0030214)2.29191167
181negative regulation of lipid storage (GO:0010888)2.28262246
182microglial cell activation (GO:0001774)10.8901925
183positive regulation of chemokine secretion (GO:0090197)10.5408294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.44955644
2* IRF8_27001747_Chip-Seq_BMDM_Mouse4.67564122
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.42771739
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.19694524
5EGR1_19374776_ChIP-ChIP_THP-1_Human4.02883464
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.76247108
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.64339303
8SCL_19346495_ChIP-Seq_HPC-7_Human3.45230154
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.40163198
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09798586
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.84180212
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.72499593
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.71245179
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69382553
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47847509
16* SPI1_23127762_ChIP-Seq_K562_Human2.45523770
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.44224607
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.42515622
19RUNX_20019798_ChIP-Seq_JUKART_Human2.34472997
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.31972282
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31196873
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.25458952
23BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06073367
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05403813
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04471741
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01458803
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.99200957
28VDR_24763502_ChIP-Seq_THP-1_Human1.98771760
29GATA1_22025678_ChIP-Seq_K562_Human1.90072805
30TFEB_21752829_ChIP-Seq_HELA_Human1.89836440
31VDR_21846776_ChIP-Seq_THP-1_Human1.84409653
32PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.84091590
33VDR_24787735_ChIP-Seq_THP-1_Human1.82051576
34* SPI1_23547873_ChIP-Seq_NB4_Human1.81651795
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81636620
36* TCF7_22412390_ChIP-Seq_EML_Mouse1.77712310
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.75213175
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74397473
39NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.70192688
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67923578
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67784903
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67784903
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67784903
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.66012988
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65782125
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65540074
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.64494412
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62683479
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.61171367
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.58621410
51ZNF263_19887448_ChIP-Seq_K562_Human1.57980788
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51125101
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.49027215
54PU_27001747_Chip-Seq_BMDM_Mouse1.48016528
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45326386
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45062845
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44917357
58* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43068892
59MAF_26560356_Chip-Seq_TH1_Human1.39690695
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38034882
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36110660
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35094925
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33832173
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.32577490
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31973533
66GATA1_19941826_ChIP-Seq_K562_Human1.31744587
67MYC_22102868_ChIP-Seq_BL_Human1.30788008
68SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30714702
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30714702
70LXR_22292898_ChIP-Seq_THP-1_Human1.30439240
71KDM2B_26808549_Chip-Seq_DND41_Human1.29834423
72MYB_26560356_Chip-Seq_TH2_Human1.29519657
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29113196
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28967582
75* LXR_22158963_ChIP-Seq_LIVER_Mouse1.27468482
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27314706
77GATA2_19941826_ChIP-Seq_K562_Human1.27259141
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.27068686
79RACK7_27058665_Chip-Seq_MCF-7_Human1.26892366
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26001870
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21720532
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21191581
83SOX2_20726797_ChIP-Seq_SW620_Human1.21119770
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20875869
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.18039376
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16075067
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.15003359
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13929010
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.12851141
90MYB_26560356_Chip-Seq_TH1_Human1.12040423
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10597357
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09768922
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09416828
94GATA3_27048872_Chip-Seq_THYMUS_Human1.09028444
95ATF3_27146783_Chip-Seq_COLON_Human1.08743743
96* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07952279
97UTX_26944678_Chip-Seq_JUKART_Human1.07058419
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06478871
99WT1_19549856_ChIP-ChIP_CCG9911_Human1.06446116
100CDX2_20551321_ChIP-Seq_CACO-2_Human1.05283537
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05037949
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04603139
103CLOCK_20551151_ChIP-Seq_293T_Human1.03466953
104SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03460750
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03315632
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02256553
107* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01846091
108UBF1/2_26484160_Chip-Seq_HMECs_Human1.00077941
109PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99758486
110GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99284797
111SMAD_19615063_ChIP-ChIP_OVARY_Human0.99209124
112FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99198587
113P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98895663
114* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96774463
115SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96406603
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96335147
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94906877
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93659106
119STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93540723
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93338140
121EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92957735
122NCOR1_26117541_ChIP-Seq_K562_Human0.92838054
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91756635
124SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86947494
125* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86584592
126STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86142954
127GATA3_26560356_Chip-Seq_TH2_Human0.84998208
128* NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82564405
129TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81874947
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81421543
131GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80809484
132SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80536493
133KDM2B_26808549_Chip-Seq_K562_Human0.79688304
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79575390
135GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78261189
136EGR1_19032775_ChIP-ChIP_M12_Human0.78187563
137RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78034363
138FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.77638274
139* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.77598373
140CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77149929
141CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76698160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol6.02711477
2MP0005058_abnormal_lysosome_morphology5.43630946
3MP0003172_abnormal_lysosome_physiology4.63042298
4* MP0006082_CNS_inflammation3.50799320
5MP0001835_abnormal_antigen_presentation3.36215232
6MP0003303_peritoneal_inflammation3.29563122
7MP0003690_abnormal_glial_cell3.22005992
8MP0005671_abnormal_response_to3.19043435
9MP0005464_abnormal_platelet_physiology3.12190980
10MP0002139_abnormal_hepatobiliary_system2.97752596
11MP0003075_altered_response_to2.86513265
12MP0009840_abnormal_foam_cell2.85750052
13MP0002419_abnormal_innate_immunity2.48763890
14MP0008004_abnormal_stomach_pH2.40408496
15MP0002877_abnormal_melanocyte_morpholog2.28340472
16MP0005451_abnormal_body_composition2.19827788
17MP0003300_gastrointestinal_ulcer2.08448326
18MP0005257_abnormal_intraocular_pressure2.04659882
19MP0003183_abnormal_peptide_metabolism1.99832408
20MP0002148_abnormal_hypersensitivity_rea1.96943390
21* MP0002452_abnormal_antigen_presenting1.96576740
22MP0003436_decreased_susceptibility_to1.95737261
23MP0005000_abnormal_immune_tolerance1.93857599
24MP0006054_spinal_hemorrhage1.92397849
25MP0001533_abnormal_skeleton_physiology1.85848993
26MP0003252_abnormal_bile_duct1.81423108
27MP0005166_decreased_susceptibility_to1.80682125
28MP0003724_increased_susceptibility_to1.80678960
29MP0000343_altered_response_to1.78137030
30MP0005167_abnormal_blood-brain_barrier1.76146934
31* MP0002723_abnormal_immune_serum1.75057596
32MP0001851_eye_inflammation1.74796289
33MP0004883_abnormal_blood_vessel1.74721264
34MP0003806_abnormal_nucleotide_metabolis1.71411617
35MP0002928_abnormal_bile_duct1.67845782
36MP0003045_fibrosis1.64161710
37MP0003705_abnormal_hypodermis_morpholog1.58880163
38* MP0001819_abnormal_immune_cell1.58091315
39* MP0001800_abnormal_humoral_immune1.57101422
40MP0004185_abnormal_adipocyte_glucose1.54882672
41MP0000465_gastrointestinal_hemorrhage1.54450463
42* MP0002420_abnormal_adaptive_immunity1.52891800
43MP0005670_abnormal_white_adipose1.52214080
44MP0002090_abnormal_vision1.51905612
45MP0005025_abnormal_response_to1.48306230
46MP0001915_intracranial_hemorrhage1.46726475
47MP0002998_abnormal_bone_remodeling1.46448087
48MP0010234_abnormal_vibrissa_follicle1.45054163
49MP0003566_abnormal_cell_adhesion1.43880358
50MP0005365_abnormal_bile_salt1.43871041
51MP0008007_abnormal_cellular_replicative1.43007980
52MP0009764_decreased_sensitivity_to1.41778762
53MP0009333_abnormal_splenocyte_physiolog1.39421514
54MP0003329_amyloid_beta_deposits1.39259380
55MP0008260_abnormal_autophagy1.36463620
56* MP0008469_abnormal_protein_level1.35987083
57MP0001845_abnormal_inflammatory_respons1.31855354
58MP0009278_abnormal_bone_marrow1.31682545
59MP0003279_aneurysm1.28583034
60MP0000689_abnormal_spleen_morphology1.24392530
61MP0002396_abnormal_hematopoietic_system1.20681565
62MP0009384_cardiac_valve_regurgitation1.20600820
63MP0000716_abnormal_immune_system1.20452855
64MP0001542_abnormal_bone_strength1.20009878
65MP0000249_abnormal_blood_vessel1.17294405
66MP0002254_reproductive_system_inflammat1.16675858
67MP0004510_myositis1.15451686
68MP0000767_abnormal_smooth_muscle1.14168486
69MP0000920_abnormal_myelination1.13244280
70MP0009785_altered_susceptibility_to1.13048054
71MP0005023_abnormal_wound_healing1.11971905
72MP0005165_increased_susceptibility_to1.11418781
73MP0008873_increased_physiological_sensi1.10752311
74MP0003656_abnormal_erythrocyte_physiolo1.10257611
75MP0004272_abnormal_basement_membrane1.09029984
76MP0002405_respiratory_system_inflammati1.08780283
77MP0005310_abnormal_salivary_gland1.06586618
78MP0000685_abnormal_immune_system1.06205898
79MP0001790_abnormal_immune_system1.05168510
80MP0005387_immune_system_phenotype1.05168510
81MP0002398_abnormal_bone_marrow1.02711420
82MP0002722_abnormal_immune_system1.01679774
83MP0001958_emphysema0.98065030
84MP0003828_pulmonary_edema0.97806933
85MP0010352_gastrointestinal_tract_polyps0.96429640
86MP0005666_abnormal_adipose_tissue0.96333881
87MP0002429_abnormal_blood_cell0.96191206
88MP0003634_abnormal_glial_cell0.95936874
89MP0001545_abnormal_hematopoietic_system0.95704715
90MP0005397_hematopoietic_system_phenotyp0.95704715
91MP0005360_urolithiasis0.95585585
92MP0002896_abnormal_bone_mineralization0.95555996
93MP0005164_abnormal_response_to0.94388924
94MP0001853_heart_inflammation0.93464696
95MP0005085_abnormal_gallbladder_physiolo0.92732204
96MP0003950_abnormal_plasma_membrane0.91703758
97MP0008874_decreased_physiological_sensi0.91438676
98MP0004947_skin_inflammation0.86819611
99MP0005390_skeleton_phenotype0.85958857
100MP0002166_altered_tumor_susceptibility0.84092727
101MP0001849_ear_inflammation0.83392877
102MP0009763_increased_sensitivity_to0.82754794
103MP0003186_abnormal_redox_activity0.81883746
104MP0004019_abnormal_vitamin_homeostasis0.81213806
105MP0003453_abnormal_keratinocyte_physiol0.79784927
106MP0010155_abnormal_intestine_physiology0.78965633
107MP0000371_diluted_coat_color0.77907723
108MP0005319_abnormal_enzyme/_coenzyme0.76866134
109MP0010386_abnormal_urinary_bladder0.75867702
110MP0000604_amyloidosis0.74820444
111MP0002060_abnormal_skin_morphology0.74049768
112MP0008438_abnormal_cutaneous_collagen0.72763541
113MP0004130_abnormal_muscle_cell0.70992729
114MP0003638_abnormal_response/metabolism_0.68609251
115MP0000609_abnormal_liver_physiology0.67995219
116MP0001243_abnormal_dermal_layer0.67952583
117MP0005647_abnormal_sex_gland0.67910751
118MP0003091_abnormal_cell_migration0.67279362
119MP0002136_abnormal_kidney_physiology0.67254580
120MP0003795_abnormal_bone_structure0.67250209
121MP0002933_joint_inflammation0.67220803
122MP0005595_abnormal_vascular_smooth0.65956209
123MP0000858_altered_metastatic_potential0.64819934
124MP0005197_abnormal_uvea_morphology0.63040080
125MP0001873_stomach_inflammation0.61825992
126MP0004808_abnormal_hematopoietic_stem0.60807705
127MP0004484_altered_response_of0.57667097
128MP0003448_altered_tumor_morphology0.57109403
129MP0010307_abnormal_tumor_latency0.56179530

Predicted human phenotypes

RankGene SetZ-score
1Glomerulonephritis (HP:0000099)9.40366806
2Complement deficiency (HP:0004431)7.34644216
3Arterial tortuosity (HP:0005116)6.13173058
4Mutism (HP:0002300)5.66869488
5Increased cerebral lipofuscin (HP:0011813)5.65605056
6Dysostosis multiplex (HP:0000943)5.44880434
7Cerebral aneurysm (HP:0004944)5.43352998
8Increased neuronal autofluorescent lipopigment (HP:0002074)5.42668971
9Vascular tortuosity (HP:0004948)5.40926932
10Abnormality of complement system (HP:0005339)5.36399178
11Retinal atrophy (HP:0001105)5.18745812
12Nephritis (HP:0000123)4.66470959
13Recurrent abscess formation (HP:0002722)4.25217113
14Hematochezia (HP:0002573)4.23219756
15Aortic aneurysm (HP:0004942)4.22863368
16Recurrent bacterial skin infections (HP:0005406)4.22401280
17Urethral obstruction (HP:0000796)4.20889845
18Mucopolysacchariduria (HP:0008155)4.08017538
19Urinary glycosaminoglycan excretion (HP:0003541)4.08017538
20Axonal loss (HP:0003447)3.99885037
21Disinhibition (HP:0000734)3.89186472
22Abnormality of polysaccharide metabolism (HP:0011012)3.83828350
23Abnormality of glycosaminoglycan metabolism (HP:0004371)3.83828350
24Abnormality of mucopolysaccharide metabolism (HP:0011020)3.83828350
25Agnosia (HP:0010524)3.77122909
26Vertebral compression fractures (HP:0002953)3.71856637
27Eczematoid dermatitis (HP:0000976)3.70452119
28Vacuolated lymphocytes (HP:0001922)3.69965138
29Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.52470382
30Neurofibrillary tangles (HP:0002185)3.47415836
31Neuronal loss in central nervous system (HP:0002529)3.45402452
32Striae distensae (HP:0001065)3.41612174
33Disproportionate tall stature (HP:0001519)3.40492915
34Upper motor neuron abnormality (HP:0002127)3.26350765
35Aortic dissection (HP:0002647)3.25831207
36Nuclear cataract (HP:0100018)3.19632870
37Colitis (HP:0002583)3.09865108
38Abnormal platelet function (HP:0011869)2.91300921
39Impaired platelet aggregation (HP:0003540)2.91300921
40Spondylolisthesis (HP:0003302)2.91023259
41Abnormality of the vasculature of the conjunctiva (HP:0008054)2.80118047
42Premature rupture of membranes (HP:0001788)2.72441270
43Amyloidosis (HP:0011034)2.68625414
44* Abnormality of liposaccharide metabolism (HP:0010968)2.67891162
45* Abnormality of glycosphingolipid metabolism (HP:0004343)2.67891162
46* Abnormality of glycolipid metabolism (HP:0010969)2.67891162
47Pathologic fracture (HP:0002756)2.65210054
48Cerebral inclusion bodies (HP:0100314)2.63398905
49Purpura (HP:0000979)2.58465588
50Arnold-Chiari malformation (HP:0002308)2.54690159
51Recurrent gram-negative bacterial infections (HP:0005420)2.44015817
52Polygenic inheritance (HP:0010982)2.43346848
53Mitral valve prolapse (HP:0001634)2.41945894
54Abnormality of macrophages (HP:0004311)2.40391850
55Rectovaginal fistula (HP:0000143)2.39092103
56Rectal fistula (HP:0100590)2.39092103
57Prolonged neonatal jaundice (HP:0006579)2.36094953
58Inflammation of the large intestine (HP:0002037)2.35780823
59Recurrent skin infections (HP:0001581)2.30789030
60J-shaped sella turcica (HP:0002680)2.27701607
61Basal ganglia calcification (HP:0002135)2.26242069
62Xanthomatosis (HP:0000991)2.25687652
63Joint stiffness (HP:0001387)2.25476412
64Thoracic kyphosis (HP:0002942)2.25084122
65Autoimmune thrombocytopenia (HP:0001973)2.24599330
66Intestinal fistula (HP:0100819)2.24307298
67Partial duplication of thumb phalanx (HP:0009944)2.23884372
68Dementia (HP:0000726)2.23144872
69Protrusio acetabuli (HP:0003179)2.22397796
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.19573156
71Increased serum ferritin (HP:0003281)2.18213354
72Gastrointestinal inflammation (HP:0004386)2.17419880
73Vaginal fistula (HP:0004320)2.16583734
74* Progressive neurologic deterioration (HP:0002344)2.16546540
75Inappropriate behavior (HP:0000719)2.16045259
76Cervical subluxation (HP:0003308)2.13619370
77Postural instability (HP:0002172)2.12612506
78Asymmetric septal hypertrophy (HP:0001670)2.10971064
79Mediastinal lymphadenopathy (HP:0100721)2.09793098
80Split foot (HP:0001839)2.06681678
81Lower limb asymmetry (HP:0100559)2.05944256
82Intestinal atresia (HP:0011100)2.03922805
83Elevated erythrocyte sedimentation rate (HP:0003565)2.03891061
84Tetraparesis (HP:0002273)2.00620906
85Systemic lupus erythematosus (HP:0002725)10.9595208
86Increased CSF protein (HP:0002922)1.98876559
87Metaphyseal irregularity (HP:0003025)1.98583729
88* Hepatosplenomegaly (HP:0001433)1.97890839
89Myositis (HP:0100614)1.95512565
90* Cardiomegaly (HP:0001640)1.94377523
91Chronic obstructive pulmonary disease (HP:0006510)1.94270892
92Obstructive lung disease (HP:0006536)1.94270892
93Malnutrition (HP:0004395)1.94099486
94Bicuspid aortic valve (HP:0001647)1.94098045
95Apathy (HP:0000741)1.94018112
96Orchitis (HP:0100796)1.93534012
97Partial duplication of the phalanx of hand (HP:0009999)1.92475118
98Petechiae (HP:0000967)1.91978456
99Skin nodule (HP:0200036)1.91434910
100Peripheral demyelination (HP:0011096)1.90800955
101Conjunctival telangiectasia (HP:0000524)1.90738552
102Exotropia (HP:0000577)1.90141046
103Progressive visual loss (HP:0000529)1.84101189
104Loss of speech (HP:0002371)1.84075764
105Beaking of vertebral bodies (HP:0004568)1.82935720
106Global brain atrophy (HP:0002283)1.82504095
107Camptodactyly of toe (HP:0001836)1.82099905
108Gingivitis (HP:0000230)1.82037036
109Diminished motivation (HP:0000745)1.80408645
110Mitral stenosis (HP:0001718)1.79695158
111Thickened calvaria (HP:0002684)1.78173423
112Interstitial pulmonary disease (HP:0006530)1.77708285
113Polycythemia (HP:0001901)1.76758209
114Clumsiness (HP:0002312)1.76423600
115Ovoid vertebral bodies (HP:0003300)1.75666097
116Protuberant abdomen (HP:0001538)1.73874984
117Personality changes (HP:0000751)1.72649349
118Achilles tendon contracture (HP:0001771)1.69762856
119Abnormality of iron homeostasis (HP:0011031)1.68480288
120Spontaneous hematomas (HP:0007420)1.68056373
121Myocardial infarction (HP:0001658)1.67100809
122Bone pain (HP:0002653)1.66331178
123Bone cyst (HP:0012062)1.66019346
124Cellulitis (HP:0100658)1.65325946
125Supranuclear gaze palsy (HP:0000605)1.64641560
126Rapidly progressive (HP:0003678)1.64543061
127Abnormality of the periventricular white matter (HP:0002518)1.64140945
128Spinal muscular atrophy (HP:0007269)1.63907706
129IgM deficiency (HP:0002850)1.62861778
130Abnormality of the Achilles tendon (HP:0005109)1.62835778
131Deep venous thrombosis (HP:0002625)1.62463657
132Abnormality of the lumbar spine (HP:0100712)1.61638730
133Sensorimotor neuropathy (HP:0007141)1.61223841
134Abnormality of monocarboxylic acid metabolism (HP:0010996)1.61201891
135Osteolytic defects of the phalanges of the hand (HP:0009771)1.61142232
136Osteolytic defects of the hand bones (HP:0009699)1.61142232
137Aneurysm (HP:0002617)1.60738190
138Obstructive sleep apnea (HP:0002870)1.60572074
139Hypoplasia of the odontoid process (HP:0003311)1.60353373
140Mucosal telangiectasiae (HP:0100579)1.59813454
141Pulmonary infiltrates (HP:0002113)1.59773426
142Neoplasm of head and neck (HP:0012288)1.58726710
143Esophageal neoplasm (HP:0100751)1.58726710
144Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.58231068

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR29.06127684
2MAPK155.74574605
3GRK74.18011625
4CSF1R3.89803512
5NME23.44427921
6TSSK63.23937225
7PDK22.49890161
8TYK22.49474179
9PAK42.32541893
10DDR22.12194016
11RIPK12.08331033
12RIPK41.98106360
13TESK11.96731478
14TAOK21.87267567
15PIM21.79660784
16PRPF4B1.78215873
17STK101.77218372
18ABL21.72377288
19CAMK1D1.71625860
20MATK1.60265028
21MOS1.59015848
22BLK1.57746302
23PDGFRA1.57542097
24TBK11.56729807
25ERN11.54179145
26VRK11.48816381
27BMPR21.45058936
28IRAK41.45018590
29TESK21.44602410
30MAPK121.44366049
31PKN21.38044802
32JAK11.37616118
33CLK11.32043677
34NEK91.31006324
35LIMK11.30677635
36MAP3K111.28204294
37MST1R1.27524917
38CAMK1G1.19003266
39IRAK31.18543625
40MAP4K11.17645921
41TTN1.17303291
42ZAP701.16858061
43MAP3K91.15577939
44MYLK1.15216140
45CAMKK21.12455821
46MAPK71.09876750
47CDC42BPA1.09341401
48GRK51.06727671
49MAP3K11.03420455
50KIT1.01802559
51EEF2K1.01546911
52PAK21.01196992
53HCK1.00589989
54MAP3K120.98847763
55JAK20.97571501
56CSK0.94764820
57MAP2K30.94471415
58ACVR1B0.93860957
59CDK30.92431728
60EPHA20.90256589
61EPHB10.88161444
62TAOK10.87566629
63LATS20.86321057
64PDK10.86213839
65CAMKK10.85606045
66ITK0.85290383
67MAPKAPK30.84938697
68ADRBK20.84472534
69ERBB40.79676308
70PRKG20.79387318
71IKBKB0.78305444
72FES0.77608586
73LYN0.75976371
74MAP3K50.74025368
75PTK20.73426324
76SIK10.71904709
77LCK0.71786076
78MAP3K20.70918762
79MAPKAPK50.66609048
80EPHB20.62460932
81TRIB30.62083805
82MAPKAPK20.61623076
83CDK60.60865232
84PIK3CG0.60642504
85SCYL20.58951820
86PTK60.57638207
87IGF1R0.57296304
88CAMK40.56834610
89TIE10.56630195
90PDPK10.56394873
91SYK0.56144231
92TXK0.55902216
93MAP3K140.55795163
94KDR0.52294556
95PDGFRB0.50873095
96PBK0.50831222
97LMTK20.50175312
98GSK3A0.49267958
99FGFR40.45369526
100ARAF0.43968949
101NEK60.43263966
102DAPK30.43034430
103MAP3K130.42869828
104MAP3K30.42136460
105CHUK0.40076569
106BTK0.39300979
107MET0.37693082
108FER0.37120877
109MAPK40.37077972
110MAP2K20.36641060
111INSR0.35618800
112PRKD20.34890756
113SIK20.34363530
114CDK80.34130734
115RPS6KA20.33873143
116SMG10.32649525
117FLT30.32637143
118ICK0.32616286
119EGFR0.30903891
120MAP3K100.30330469
121RET0.29335339
122STK110.28785129
123MARK30.28579433
124FGR0.28129043
125EIF2AK20.27634495
126RPS6KA40.26384599
127MELK0.25670129
128TRPM70.25407691
129IKBKE0.25305097
130PRKD10.24840907
131KSR20.23520654
132RPS6KA60.19563754
133IRAK20.19347513
134RPS6KL10.19038698
135RPS6KC10.19038698
136PRKAA20.19011712
137MAP3K60.18267918
138ABL10.17696279
139FGFR30.15889526
140PRKCD0.14841800
141JAK30.14081873
142MAP3K80.12522380

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.58121918
2* Glycosaminoglycan degradation_Homo sapiens_hsa005313.54034222
3* Lysosome_Homo sapiens_hsa041423.42517966
4* Other glycan degradation_Homo sapiens_hsa005113.13114297
5Osteoclast differentiation_Homo sapiens_hsa043803.06009317
6Prion diseases_Homo sapiens_hsa050203.05447807
7Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.58700858
8Pertussis_Homo sapiens_hsa051332.53583815
9Leishmaniasis_Homo sapiens_hsa051402.39868463
10Antigen processing and presentation_Homo sapiens_hsa046122.36026540
11B cell receptor signaling pathway_Homo sapiens_hsa046622.34587366
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.94472161
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80292220
14Asthma_Homo sapiens_hsa053101.80024452
15Nitrogen metabolism_Homo sapiens_hsa009101.73050998
16Allograft rejection_Homo sapiens_hsa053301.65155862
17Tuberculosis_Homo sapiens_hsa051521.60777390
18Toxoplasmosis_Homo sapiens_hsa051451.57905390
19Legionellosis_Homo sapiens_hsa051341.56998741
20Complement and coagulation cascades_Homo sapiens_hsa046101.55442426
21Vibrio cholerae infection_Homo sapiens_hsa051101.51504154
22* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.49116426
23Galactose metabolism_Homo sapiens_hsa000521.48456629
24Graft-versus-host disease_Homo sapiens_hsa053321.44132471
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38359022
26Sphingolipid metabolism_Homo sapiens_hsa006001.37924329
27Sulfur metabolism_Homo sapiens_hsa009201.37538438
28Autoimmune thyroid disease_Homo sapiens_hsa053201.37347612
29* Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37173881
30Pancreatic cancer_Homo sapiens_hsa052121.30670321
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30466880
32Collecting duct acid secretion_Homo sapiens_hsa049661.27742202
33Chronic myeloid leukemia_Homo sapiens_hsa052201.26690544
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26060377
35* Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24769034
36Bladder cancer_Homo sapiens_hsa052191.24690536
37Platelet activation_Homo sapiens_hsa046111.21905178
38Hematopoietic cell lineage_Homo sapiens_hsa046401.17166187
39Chemokine signaling pathway_Homo sapiens_hsa040621.14139037
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.12889923
41Viral myocarditis_Homo sapiens_hsa054161.12100781
42Endocytosis_Homo sapiens_hsa041441.11637411
43Type I diabetes mellitus_Homo sapiens_hsa049401.11635508
44Colorectal cancer_Homo sapiens_hsa052101.11421032
45Influenza A_Homo sapiens_hsa051641.09462289
46Measles_Homo sapiens_hsa051621.07519823
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06717321
48Ether lipid metabolism_Homo sapiens_hsa005651.06530747
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04723058
50Salmonella infection_Homo sapiens_hsa051321.04570049
51Phagosome_Homo sapiens_hsa041451.01882742
52Renin-angiotensin system_Homo sapiens_hsa046140.99699549
53Rheumatoid arthritis_Homo sapiens_hsa053230.97722253
54Pentose phosphate pathway_Homo sapiens_hsa000300.96475335
55Renal cell carcinoma_Homo sapiens_hsa052110.96278227
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.95984168
57Fructose and mannose metabolism_Homo sapiens_hsa000510.95643491
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92337849
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.91336831
60Estrogen signaling pathway_Homo sapiens_hsa049150.87613226
61Apoptosis_Homo sapiens_hsa042100.87055963
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85471183
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84492708
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83982851
65PPAR signaling pathway_Homo sapiens_hsa033200.83205139
66Hepatitis B_Homo sapiens_hsa051610.81539905
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78702055
68Malaria_Homo sapiens_hsa051440.78037083
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.77450794
70ABC transporters_Homo sapiens_hsa020100.75822474
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73047017
72TNF signaling pathway_Homo sapiens_hsa046680.68997502
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67951059
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67814531
75Adherens junction_Homo sapiens_hsa045200.65098162
76Notch signaling pathway_Homo sapiens_hsa043300.64819166
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.63632852
78MAPK signaling pathway_Homo sapiens_hsa040100.63302138
79Glutathione metabolism_Homo sapiens_hsa004800.62569864
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.61373486
81Rap1 signaling pathway_Homo sapiens_hsa040150.60902322
82Shigellosis_Homo sapiens_hsa051310.60597511
83T cell receptor signaling pathway_Homo sapiens_hsa046600.60563932
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59095349
85Renin secretion_Homo sapiens_hsa049240.58974283
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57377802
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56774772
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54711500
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.54611219
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54412140
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.52457310
92African trypanosomiasis_Homo sapiens_hsa051430.52385070
93Proteoglycans in cancer_Homo sapiens_hsa052050.52367989
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51919902
95Acute myeloid leukemia_Homo sapiens_hsa052210.51478037
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.51072179
97Amoebiasis_Homo sapiens_hsa051460.48932010
98Salivary secretion_Homo sapiens_hsa049700.48140973
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47273125
100N-Glycan biosynthesis_Homo sapiens_hsa005100.46428799
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46047960
102Choline metabolism in cancer_Homo sapiens_hsa052310.45830845
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44927769
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.44882271
105Non-small cell lung cancer_Homo sapiens_hsa052230.44827746
106VEGF signaling pathway_Homo sapiens_hsa043700.44780761
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44172444
108Arachidonic acid metabolism_Homo sapiens_hsa005900.42902014
109Glioma_Homo sapiens_hsa052140.42105974
110FoxO signaling pathway_Homo sapiens_hsa040680.41035831
111GnRH signaling pathway_Homo sapiens_hsa049120.40898486
112Inositol phosphate metabolism_Homo sapiens_hsa005620.40029692
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38504690
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38391561
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.37403579
116Mineral absorption_Homo sapiens_hsa049780.34722238
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34549881
118Carbon metabolism_Homo sapiens_hsa012000.34421091
119Focal adhesion_Homo sapiens_hsa045100.33658421
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.33242412
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32876155
122Type II diabetes mellitus_Homo sapiens_hsa049300.32443981
123Prolactin signaling pathway_Homo sapiens_hsa049170.31341700
124Epstein-Barr virus infection_Homo sapiens_hsa051690.30651169
125cAMP signaling pathway_Homo sapiens_hsa040240.29945560
126Starch and sucrose metabolism_Homo sapiens_hsa005000.29258124
127Ras signaling pathway_Homo sapiens_hsa040140.29164101
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28712570
129Dorso-ventral axis formation_Homo sapiens_hsa043200.28641916
130HIF-1 signaling pathway_Homo sapiens_hsa040660.28452594
131Herpes simplex infection_Homo sapiens_hsa051680.28256669
132Small cell lung cancer_Homo sapiens_hsa052220.28105016
133Hepatitis C_Homo sapiens_hsa051600.26529472
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25959766
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25285729
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24780332
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24584537
138Insulin resistance_Homo sapiens_hsa049310.23694568

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