HEXA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.07327051
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.07327051
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.07327051
4modulation by symbiont of host immune response (GO:0052553)6.07327051
5positive regulation by symbiont of host defense response (GO:0052509)6.07327051
6modulation by symbiont of host defense response (GO:0052031)6.07327051
7daunorubicin metabolic process (GO:0044597)5.92724152
8polyketide metabolic process (GO:0030638)5.92724152
9doxorubicin metabolic process (GO:0044598)5.92724152
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.42578241
11regulation of interferon-beta biosynthetic process (GO:0045357)5.25948078
12oligosaccharide catabolic process (GO:0009313)4.99412508
13macrophage activation involved in immune response (GO:0002281)4.95992312
14neutrophil activation involved in immune response (GO:0002283)4.85762083
15immunoglobulin mediated immune response (GO:0016064)4.62642262
16glycolipid catabolic process (GO:0019377)4.56781793
17positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.54229685
18response to peptidoglycan (GO:0032494)4.53548183
19amino sugar catabolic process (GO:0046348)4.50205026
20ceramide catabolic process (GO:0046514)4.17084376
21regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.06719946
22negative regulation of nitric oxide biosynthetic process (GO:0045019)4.02962571
23cytidine catabolic process (GO:0006216)4.02865617
24cytidine deamination (GO:0009972)4.02865617
25cytidine metabolic process (GO:0046087)4.02865617
26positive regulation of interferon-alpha production (GO:0032727)3.97146226
27apoptotic cell clearance (GO:0043277)3.92139276
28microglial cell activation (GO:0001774)3.89728926
29respiratory burst (GO:0045730)3.78526724
30response to host immune response (GO:0052572)3.77208374
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.77208374
32sphingolipid catabolic process (GO:0030149)3.72231651
33regulation of interferon-alpha production (GO:0032647)3.72178258
34membrane lipid catabolic process (GO:0046466)3.71371826
35pinocytosis (GO:0006907)3.66781260
36aminoglycoside antibiotic metabolic process (GO:0030647)3.58192363
37phagocytosis, recognition (GO:0006910)3.55080057
38hydrogen peroxide biosynthetic process (GO:0050665)3.54341180
39negative regulation of interleukin-12 production (GO:0032695)3.49602637
40regulation of B cell receptor signaling pathway (GO:0050855)3.48756468
41reactive oxygen species biosynthetic process (GO:1903409)3.48600544
42macrophage activation (GO:0042116)3.46566761
43positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.41478078
44positive regulation of macrophage cytokine production (GO:0060907)3.38730016
45positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.37161410
46response to host (GO:0075136)3.36344418
47response to host defenses (GO:0052200)3.36344418
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.36344418
49lytic vacuole organization (GO:0080171)3.35890304
50lysosome organization (GO:0007040)3.35890304
51N-acetylneuraminate metabolic process (GO:0006054)3.35314436
52production of molecular mediator involved in inflammatory response (GO:0002532)3.34010855
53negative regulation of phagocytosis (GO:0050765)3.33556581
54B cell mediated immunity (GO:0019724)3.33256825
55barbed-end actin filament capping (GO:0051016)3.24351571
56virion attachment to host cell (GO:0019062)3.22585569
57adhesion of symbiont to host cell (GO:0044650)3.22585569
58myeloid cell activation involved in immune response (GO:0002275)3.20145248
59mannose metabolic process (GO:0006013)3.18463497
60amyloid precursor protein catabolic process (GO:0042987)3.16012949
61positive regulation of antigen processing and presentation (GO:0002579)3.14082344
62positive regulation of chemokine biosynthetic process (GO:0045080)3.10997375
63adhesion of symbiont to host (GO:0044406)3.09532388
64regulation of interleukin-8 biosynthetic process (GO:0045414)3.07220477
65response to muramyl dipeptide (GO:0032495)3.05275242
66phagocytosis, engulfment (GO:0006911)3.01747351
67cellular response to thyroid hormone stimulus (GO:0097067)3.01308864
68neutrophil mediated immunity (GO:0002446)3.01023503
69pyrimidine ribonucleoside catabolic process (GO:0046133)3.00040933
70detection of molecule of bacterial origin (GO:0032490)2.99477758
71granulocyte activation (GO:0036230)2.98974675
72negative regulation of interleukin-6 production (GO:0032715)2.97842606
73glycoside metabolic process (GO:0016137)2.97175717
74regulation of apoptotic cell clearance (GO:2000425)2.95886264
75neutrophil activation (GO:0042119)2.93690445
76lipopolysaccharide-mediated signaling pathway (GO:0031663)2.89604531
77regulation of antigen processing and presentation (GO:0002577)2.89241256
78positive regulation of bone remodeling (GO:0046852)2.88944312
79positive regulation of bone resorption (GO:0045780)2.88944312
80negative regulation of bone resorption (GO:0045779)2.88086836
81regulation of macrophage cytokine production (GO:0010935)2.85153696
82sphingosine metabolic process (GO:0006670)2.84763077
83interferon-gamma production (GO:0032609)2.84170285
84regulation of mononuclear cell migration (GO:0071675)2.83581864
85positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.81166778
86maintenance of protein location in nucleus (GO:0051457)2.80616929
87regulation of cytokine secretion involved in immune response (GO:0002739)2.77168292
88regulation of cholesterol storage (GO:0010885)2.76229199
89positive regulation of interferon-beta production (GO:0032728)2.74852588
90regulation of membrane protein ectodomain proteolysis (GO:0051043)2.73414652
91eosinophil chemotaxis (GO:0048245)2.72864460
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.70788919
93antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70788919
94glycosphingolipid catabolic process (GO:0046479)2.70788083
95* keratan sulfate catabolic process (GO:0042340)2.70202256
96phagosome maturation (GO:0090382)2.69878933
97positive regulation of mast cell activation (GO:0033005)2.69589063
98L-alpha-amino acid transmembrane transport (GO:1902475)2.69538101
99peptide catabolic process (GO:0043171)2.69163413
100positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.68032699
101negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.67493566
102regulation of interferon-gamma biosynthetic process (GO:0045072)2.67185107
103regulation of macrophage chemotaxis (GO:0010758)2.64977688
104cyclooxygenase pathway (GO:0019371)2.64931398
105positive regulation of tumor necrosis factor production (GO:0032760)2.64628143
106plasma lipoprotein particle clearance (GO:0034381)2.63777194
107endosome to melanosome transport (GO:0035646)2.63574181
108endosome to pigment granule transport (GO:0043485)2.63574181
109regulation of mammary gland epithelial cell proliferation (GO:0033599)2.63306432
110regulation of mast cell degranulation (GO:0043304)2.63134759
111hormone catabolic process (GO:0042447)2.63028363
112regulation of phagocytosis (GO:0050764)2.62496014
113positive regulation of cholesterol efflux (GO:0010875)2.61339767
114positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.59885125
115negative regulation of granulocyte differentiation (GO:0030853)2.59508834
116Arp2/3 complex-mediated actin nucleation (GO:0034314)2.58765258
117regulation of cholesterol esterification (GO:0010872)2.58203806
118leukocyte mediated cytotoxicity (GO:0001909)2.57185632
119negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.56642054
120positive regulation of tissue remodeling (GO:0034105)2.56409433
121natural killer cell mediated cytotoxicity (GO:0042267)2.55769670
122natural killer cell mediated immunity (GO:0002228)2.55769670
123eosinophil migration (GO:0072677)2.55062533
124positive regulation of leukocyte degranulation (GO:0043302)2.54765297
125low-density lipoprotein particle clearance (GO:0034383)2.53748224
126regulation of mast cell activation (GO:0033003)2.53709423
127response to thyroid hormone (GO:0097066)2.53492473
128positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.52756326
129negative regulation of interleukin-17 production (GO:0032700)2.52188724
130regulation of chemokine biosynthetic process (GO:0045073)2.51926184
131regulation of superoxide anion generation (GO:0032928)2.51594608
132T-helper 1 type immune response (GO:0042088)2.51588926
133negative regulation of mast cell activation (GO:0033004)2.51258455
134melanin biosynthetic process (GO:0042438)2.49807015
135membrane protein intracellular domain proteolysis (GO:0031293)2.49500518
136muscle organ morphogenesis (GO:0048644)2.48240693
137negative regulation of cytokine production involved in immune response (GO:0002719)2.48002148
138regulation of mast cell activation involved in immune response (GO:0033006)2.47686555
139cellular response to arsenic-containing substance (GO:0071243)2.47508276
140diol metabolic process (GO:0034311)2.47296535
141regulation of vitamin D biosynthetic process (GO:0060556)2.46343094
142positive regulation of cholesterol transport (GO:0032376)2.45819895
143positive regulation of sterol transport (GO:0032373)2.45819895
144glucosamine-containing compound catabolic process (GO:1901072)2.45719773
145intracellular pH reduction (GO:0051452)2.43003554
146* glycosphingolipid metabolic process (GO:0006687)2.42593170
147positive regulation of monocyte chemotaxis (GO:0090026)2.42556119
148cholesterol efflux (GO:0033344)2.41263462
149negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.40215122
150fat-soluble vitamin biosynthetic process (GO:0042362)2.39714190
151pH reduction (GO:0045851)2.38390476
152protein localization to endosome (GO:0036010)2.35926075
153transferrin transport (GO:0033572)2.35426316
154regulation of leukocyte degranulation (GO:0043300)2.33665119
155myeloid dendritic cell differentiation (GO:0043011)2.33292037
156negative regulation of lipid storage (GO:0010888)2.32414024
157positive regulation of cellular amide metabolic process (GO:0034250)2.31698708
158endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.31269499
159NIK/NF-kappaB signaling (GO:0038061)2.30016180
160interferon-gamma-mediated signaling pathway (GO:0060333)2.29902379
161angiotensin maturation (GO:0002003)2.26881780
162low-density lipoprotein particle remodeling (GO:0034374)2.26690901
163Golgi transport vesicle coating (GO:0048200)2.25177058
164COPI coating of Golgi vesicle (GO:0048205)2.25177058
165nitric oxide biosynthetic process (GO:0006809)2.25106262
166monocyte chemotaxis (GO:0002548)2.23342486
167regulation of nitric oxide biosynthetic process (GO:0045428)2.23111125
168phospholipid efflux (GO:0033700)2.23050935
169cellular response to type I interferon (GO:0071357)2.23032893
170type I interferon signaling pathway (GO:0060337)2.23032893
171glycosylceramide metabolic process (GO:0006677)2.21762788
172glial cell migration (GO:0008347)2.21699177
173response to type I interferon (GO:0034340)2.21452120
174* hyaluronan catabolic process (GO:0030214)2.21320162
175regulation of extracellular matrix disassembly (GO:0010715)2.21151820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.41681847
2* IRF8_21731497_ChIP-ChIP_J774_Mouse4.44071386
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.89425679
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.43239268
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.43239268
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.43239268
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.12804965
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.07138937
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71662983
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68278970
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.59913227
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.47743782
13* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.46401232
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38724126
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.32214449
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14753668
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.06756032
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.04237731
19SPI1_23547873_ChIP-Seq_NB4_Human1.99417094
20PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.94795733
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.92673398
22RXR_22158963_ChIP-Seq_LIVER_Mouse1.92112495
23VDR_24787735_ChIP-Seq_THP-1_Human1.87853283
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85354263
25SCL_19346495_ChIP-Seq_HPC-7_Human1.80276383
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.78226072
27SPI1_23127762_ChIP-Seq_K562_Human1.74453624
28TFEB_21752829_ChIP-Seq_HELA_Human1.69348092
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69222791
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68609481
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65959296
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65906180
33PPARA_22158963_ChIP-Seq_LIVER_Mouse1.65525953
34E2F7_22180533_ChIP-Seq_HELA_Human1.65342997
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65079099
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64564259
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62322250
38VDR_21846776_ChIP-Seq_THP-1_Human1.59774428
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59477530
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.59015648
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52023697
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51007626
43LXR_22158963_ChIP-Seq_LIVER_Mouse1.50178034
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45871329
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45097562
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.44284027
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41820315
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39850214
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38358193
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38005217
51* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37465039
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37335806
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.35078415
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34302722
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34030913
56MYC_22102868_ChIP-Seq_BL_Human1.33014243
57ZNF263_19887448_ChIP-Seq_K562_Human1.31757101
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30734490
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30465526
60TCF7_22412390_ChIP-Seq_EML_Mouse1.28822917
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.28392818
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.27663252
63NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26644761
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25404796
65JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24851242
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23457138
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22692704
68VDR_24763502_ChIP-Seq_THP-1_Human1.22169868
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22063150
70* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21739848
71LXR_22292898_ChIP-Seq_THP-1_Human1.20943659
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.20526891
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19270974
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18422654
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17972314
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17962909
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16795765
78STAT1_20625510_ChIP-Seq_HELA_Human1.15680891
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15212337
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13849447
81MAF_26560356_Chip-Seq_TH1_Human1.13065600
82MYB_26560356_Chip-Seq_TH2_Human1.12971203
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12073338
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10670350
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.09530395
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08689616
87EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08640733
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08466316
89PU_27001747_Chip-Seq_BMDM_Mouse1.07540246
90STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07122700
91SOX2_20726797_ChIP-Seq_SW620_Human1.06826156
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06665069
93* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05938174
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04807489
95CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04662290
96NCOR1_26117541_ChIP-Seq_K562_Human1.04554937
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04437693
98KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04146536
99MYB_26560356_Chip-Seq_TH1_Human1.03306035
100SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03303826
101* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01283955
102BCL6_27268052_Chip-Seq_Bcells_Human0.99721351
103CLOCK_20551151_ChIP-Seq_293T_Human0.99552426
104RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98699882
105FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98633172
106PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98451060
107GATA2_21666600_ChIP-Seq_HMVEC_Human0.97957304
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97240791
109SMAD_19615063_ChIP-ChIP_OVARY_Human0.96677325
110GATA1_19941826_ChIP-Seq_K562_Human0.96200185
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95284652
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94808265
113SRF_21415370_ChIP-Seq_HL-1_Mouse0.93668571
114P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93066939
115UTX_26944678_Chip-Seq_JUKART_Human0.90057774
116PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88554385
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87839587
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87789445
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87365402
120RACK7_27058665_Chip-Seq_MCF-7_Human0.85589628
121SPI1_20517297_ChIP-Seq_HL60_Human0.85563216
122CDX2_20551321_ChIP-Seq_CACO-2_Human0.85024880
123ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84880598
124BCOR_27268052_Chip-Seq_Bcells_Human0.83688204
125* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83041626
126GATA1_22025678_ChIP-Seq_K562_Human0.82598293
127TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82246772
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.81826916
129ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81328452
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80634728
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76022457
132FOXO3_23340844_ChIP-Seq_DLD1_Human0.75323198
133GATA3_27048872_Chip-Seq_THYMUS_Human0.74958987

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.78134577
2MP0003172_abnormal_lysosome_physiology3.67945473
3MP0006082_CNS_inflammation3.64672877
4MP0001835_abnormal_antigen_presentation3.26463705
5MP0003436_decreased_susceptibility_to3.17061686
6MP0005257_abnormal_intraocular_pressure3.10224774
7MP0002139_abnormal_hepatobiliary_system2.89495178
8MP0003183_abnormal_peptide_metabolism2.82147725
9MP0009840_abnormal_foam_cell2.62675523
10MP0008438_abnormal_cutaneous_collagen2.58245735
11MP0002419_abnormal_innate_immunity2.43588115
12MP0003303_peritoneal_inflammation2.42415062
13MP0002254_reproductive_system_inflammat2.39114313
14MP0003191_abnormal_cellular_cholesterol2.36554559
15MP0003705_abnormal_hypodermis_morpholog2.30684923
16MP0005000_abnormal_immune_tolerance2.22547719
17MP0003806_abnormal_nucleotide_metabolis2.19731340
18MP0002148_abnormal_hypersensitivity_rea2.11695424
19MP0000343_altered_response_to2.02686332
20MP0005025_abnormal_response_to1.99501269
21MP0003011_delayed_dark_adaptation1.91057539
22MP0009785_altered_susceptibility_to1.90903125
23MP0004264_abnormal_extraembryonic_tissu1.86945289
24MP0002452_abnormal_antigen_presenting1.81465792
25MP0001790_abnormal_immune_system1.81246532
26MP0005387_immune_system_phenotype1.81246532
27MP0004858_abnormal_nervous_system1.79988076
28MP0001533_abnormal_skeleton_physiology1.79407875
29MP0000372_irregular_coat_pigmentation1.73743930
30MP0003448_altered_tumor_morphology1.65245109
31MP0003566_abnormal_cell_adhesion1.58918789
32MP0002877_abnormal_melanocyte_morpholog1.57210944
33MP0005408_hypopigmentation1.55748462
34MP0002723_abnormal_immune_serum1.54283015
35MP0002405_respiratory_system_inflammati1.53421599
36MP0005171_absent_coat_pigmentation1.51441957
37MP0001800_abnormal_humoral_immune1.51106067
38MP0001819_abnormal_immune_cell1.50202002
39MP0003300_gastrointestinal_ulcer1.49927770
40MP0005310_abnormal_salivary_gland1.48794426
41MP0002420_abnormal_adaptive_immunity1.48697337
42MP0003075_altered_response_to1.47840674
43MP0005365_abnormal_bile_salt1.46460547
44MP0005464_abnormal_platelet_physiology1.45561600
45MP0000685_abnormal_immune_system1.45379172
46MP0000015_abnormal_ear_pigmentation1.45130760
47MP0000858_altered_metastatic_potential1.44092633
48MP0005451_abnormal_body_composition1.43366464
49MP0010352_gastrointestinal_tract_polyps1.42881498
50MP0002998_abnormal_bone_remodeling1.40581433
51MP0005671_abnormal_response_to1.38945124
52MP0005075_abnormal_melanosome_morpholog1.37705596
53MP0003195_calcinosis1.37617634
54MP0003724_increased_susceptibility_to1.36270360
55MP0001845_abnormal_inflammatory_respons1.35477556
56MP0003690_abnormal_glial_cell1.32158987
57MP0000604_amyloidosis1.25028584
58MP0010307_abnormal_tumor_latency1.23513157
59MP0005390_skeleton_phenotype1.23410317
60MP0008469_abnormal_protein_level1.22753440
61MP0002332_abnormal_exercise_endurance1.19155998
62MP0005023_abnormal_wound_healing1.18382741
63MP0005165_increased_susceptibility_to1.16722382
64MP0009333_abnormal_splenocyte_physiolog1.16557088
65MP0004947_skin_inflammation1.15426145
66MP0001853_heart_inflammation1.12994640
67MP0000689_abnormal_spleen_morphology1.12504983
68MP0003329_amyloid_beta_deposits1.11850521
69MP0010386_abnormal_urinary_bladder1.11089446
70MP0002277_abnormal_respiratory_mucosa1.10789729
71MP0000716_abnormal_immune_system1.10652222
72MP0008260_abnormal_autophagy1.08834132
73MP0000490_abnormal_crypts_of1.08146808
74MP0004782_abnormal_surfactant_physiolog1.04346405
75MP0003279_aneurysm1.04184737
76MP0004510_myositis1.03055431
77MP0003828_pulmonary_edema1.02899793
78MP0005164_abnormal_response_to1.02818207
79MP0002429_abnormal_blood_cell0.99133493
80MP0005167_abnormal_blood-brain_barrier0.98031399
81MP0004883_abnormal_blood_vessel0.97131812
82MP0001849_ear_inflammation0.96958822
83MP0002396_abnormal_hematopoietic_system0.95867543
84MP0002722_abnormal_immune_system0.94455333
85MP0000465_gastrointestinal_hemorrhage0.93518277
86* MP0003795_abnormal_bone_structure0.92079227
87MP0009278_abnormal_bone_marrow0.91646030
88MP0000249_abnormal_blood_vessel0.91380978
89MP0000371_diluted_coat_color0.90655045
90MP0003656_abnormal_erythrocyte_physiolo0.90359045
91MP0008004_abnormal_stomach_pH0.89339444
92MP0010155_abnormal_intestine_physiology0.89333607
93MP0002398_abnormal_bone_marrow0.89294408
94MP0010329_abnormal_lipoprotein_level0.87687187
95MP0003186_abnormal_redox_activity0.87020743
96MP0001958_emphysema0.86721386
97MP0002837_dystrophic_cardiac_calcinosis0.85307060
98MP0005360_urolithiasis0.83272495
99MP0009764_decreased_sensitivity_to0.83272316
100* MP0000920_abnormal_myelination0.82539032
101MP0005197_abnormal_uvea_morphology0.82416173
102MP0005166_decreased_susceptibility_to0.81374455
103MP0002295_abnormal_pulmonary_circulatio0.81015868
104MP0005584_abnormal_enzyme/coenzyme_acti0.77992861
105MP0009643_abnormal_urine_homeostasis0.77468841
106MP0000767_abnormal_smooth_muscle0.77156272
107MP0005174_abnormal_tail_pigmentation0.76995938
108MP0003453_abnormal_keratinocyte_physiol0.76893959
109MP0001756_abnormal_urination0.76579692
110MP0004019_abnormal_vitamin_homeostasis0.76203561
111MP0003091_abnormal_cell_migration0.76136395
112MP0003950_abnormal_plasma_membrane0.75878914
113MP0004272_abnormal_basement_membrane0.75819611
114MP0005595_abnormal_vascular_smooth0.74506836
115MP0001324_abnormal_eye_pigmentation0.71616408
116MP0005319_abnormal_enzyme/_coenzyme0.71114354
117MP0005397_hematopoietic_system_phenotyp0.70209838
118MP0001545_abnormal_hematopoietic_system0.70209838
119MP0002933_joint_inflammation0.69570525
120MP0000678_abnormal_parathyroid_gland0.69013999
121MP0000358_abnormal_cell_content/0.68706649
122MP0006054_spinal_hemorrhage0.66430244
123MP0000609_abnormal_liver_physiology0.66280386
124MP0005508_abnormal_skeleton_morphology0.65600244
125MP0001542_abnormal_bone_strength0.65283106
126MP0009763_increased_sensitivity_to0.63566897
127* MP0000598_abnormal_liver_morphology0.63322506
128MP0008961_abnormal_basal_metabolism0.63263566
129MP0001851_eye_inflammation0.62323942
130MP0001243_abnormal_dermal_layer0.61198481

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)5.90034834
2Increased cerebral lipofuscin (HP:0011813)5.83283139
3Systemic lupus erythematosus (HP:0002725)5.19598514
4Dysostosis multiplex (HP:0000943)5.18825648
5Increased neuronal autofluorescent lipopigment (HP:0002074)5.10487204
6Recurrent abscess formation (HP:0002722)4.93824820
7Urinary glycosaminoglycan excretion (HP:0003541)4.42377222
8Mucopolysacchariduria (HP:0008155)4.42377222
9Eczematoid dermatitis (HP:0000976)4.42011741
10Recurrent bacterial skin infections (HP:0005406)4.14303086
11Abnormality of mucopolysaccharide metabolism (HP:0011020)4.12484222
12Abnormality of polysaccharide metabolism (HP:0011012)4.12484222
13Abnormality of glycosaminoglycan metabolism (HP:0004371)4.12484222
14Abnormality of macrophages (HP:0004311)3.91325711
15Recurrent gram-negative bacterial infections (HP:0005420)3.83673232
16* Abnormality of liposaccharide metabolism (HP:0010968)3.71405057
17* Abnormality of glycosphingolipid metabolism (HP:0004343)3.71405057
18* Abnormality of glycolipid metabolism (HP:0010969)3.71405057
19Glomerulonephritis (HP:0000099)3.49315345
20Axonal loss (HP:0003447)3.42881540
21Upper motor neuron abnormality (HP:0002127)3.31833980
22Elevated erythrocyte sedimentation rate (HP:0003565)3.28748438
23Disinhibition (HP:0000734)3.22436157
24Nuclear cataract (HP:0100018)3.18847338
25Myositis (HP:0100614)3.10803318
26Multiple enchondromatosis (HP:0005701)3.08100488
27Gingivitis (HP:0000230)3.02199220
28Prolonged neonatal jaundice (HP:0006579)3.01568744
29Loss of speech (HP:0002371)3.00848744
30Orchitis (HP:0100796)2.97613738
31Agnosia (HP:0010524)2.96266007
32Neurofibrillary tangles (HP:0002185)2.94643391
33Cervical subluxation (HP:0003308)2.93208148
34Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.88639073
35Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.78686670
36Mutism (HP:0002300)2.73017356
37Purpura (HP:0000979)2.72798349
38Peritonitis (HP:0002586)2.69731797
39Bilateral microphthalmos (HP:0007633)2.66855263
40Hand muscle atrophy (HP:0009130)2.62870476
41Abnormality of complement system (HP:0005339)2.56407414
42Cardiomegaly (HP:0001640)2.50554352
43Cerebral aneurysm (HP:0004944)2.46570157
44Vertebral compression fractures (HP:0002953)2.45148492
45Pathologic fracture (HP:0002756)2.44122260
46Obstructive lung disease (HP:0006536)2.33752931
47Chronic obstructive pulmonary disease (HP:0006510)2.33752931
48Asymmetric septal hypertrophy (HP:0001670)2.30117011
49Reduced antithrombin III activity (HP:0001976)2.28503399
50Recurrent skin infections (HP:0001581)2.26929729
51Albinism (HP:0001022)2.26025570
52Nasal polyposis (HP:0100582)2.25533890
53J-shaped sella turcica (HP:0002680)2.22984070
54Complement deficiency (HP:0004431)2.21575755
55Mediastinal lymphadenopathy (HP:0100721)2.18847836
56Spinal muscular atrophy (HP:0007269)2.17690891
57Xanthomatosis (HP:0000991)2.17377301
58Cellulitis (HP:0100658)2.17316649
59Neuronal loss in central nervous system (HP:0002529)2.17166500
60Hypoplasia of the fovea (HP:0007750)2.16453511
61Aplasia/Hypoplasia of the fovea (HP:0008060)2.16453511
62Abnormality of the nasal mucosa (HP:0000433)2.16449032
63Spondylolisthesis (HP:0003302)2.15871625
64Increased serum ferritin (HP:0003281)2.15699497
65Upper limb amyotrophy (HP:0009129)2.13269861
66Distal upper limb amyotrophy (HP:0007149)2.13269861
67Autoimmune thrombocytopenia (HP:0001973)2.12998829
68Increased CSF protein (HP:0002922)2.11791238
69Basal ganglia calcification (HP:0002135)2.09332336
70Cerebral inclusion bodies (HP:0100314)2.08808710
71Skin nodule (HP:0200036)2.07365499
72Mitral stenosis (HP:0001718)2.06148122
73Progressive neurologic deterioration (HP:0002344)2.05237248
74Cheilitis (HP:0100825)2.05173425
75Thoracic kyphosis (HP:0002942)2.04071240
76Periodontitis (HP:0000704)2.03479250
77Myocardial infarction (HP:0001658)2.02932714
78Joint stiffness (HP:0001387)2.01015986
79Abnormality of the vasculature of the conjunctiva (HP:0008054)2.00132018
80Retinal atrophy (HP:0001105)1.99675979
81Premature rupture of membranes (HP:0001788)1.98815868
82Hepatosplenomegaly (HP:0001433)1.98071239
83Nephritis (HP:0000123)1.97914146
84Petechiae (HP:0000967)1.96443963
85Testicular atrophy (HP:0000029)1.95806523
86Beaking of vertebral bodies (HP:0004568)1.95736601
87Personality changes (HP:0000751)1.95733453
88Fused cervical vertebrae (HP:0002949)1.92830264
89Amyloidosis (HP:0011034)1.91191826
90Hyperinsulinemic hypoglycemia (HP:0000825)1.89655427
91Vaginal fistula (HP:0004320)1.89081795
92Abnormal cartilage morphology (HP:0002763)1.86643202
93Pulmonary infiltrates (HP:0002113)1.86254899
94Ovoid vertebral bodies (HP:0003300)1.85412523
95Hepatoblastoma (HP:0002884)1.85175150
96Global brain atrophy (HP:0002283)1.84402686
97Recurrent fungal infections (HP:0002841)1.84159180
98Hypokinesia (HP:0002375)1.83059057
99Mesangial abnormality (HP:0001966)1.82356797
100Abnormality of the intrinsic pathway (HP:0010989)1.82195846
101Peripheral demyelination (HP:0011096)1.81751180
102Metaphyseal irregularity (HP:0003025)1.81590704
103Osteolytic defects of the hand bones (HP:0009699)1.80535844
104Osteolytic defects of the phalanges of the hand (HP:0009771)1.80535844
105Fasciculations (HP:0002380)1.80063649
106Protrusio acetabuli (HP:0003179)1.79691345
107Abnormality of iron homeostasis (HP:0011031)1.79536083
108Rectovaginal fistula (HP:0000143)1.79140228
109Rectal fistula (HP:0100590)1.79140228
110Abnormality of the lumbar spine (HP:0100712)1.78661055
111Urticaria (HP:0001025)1.78573011
112Abnormality of the pleura (HP:0002103)1.77758446
113Chest pain (HP:0100749)1.76796088
114Abnormality of the fovea (HP:0000493)1.76778538
115Protuberant abdomen (HP:0001538)1.76045274
116Esophageal neoplasm (HP:0100751)1.75589459
117Neoplasm of head and neck (HP:0012288)1.75589459
118Interstitial pulmonary disease (HP:0006530)1.75376480
119* Dementia (HP:0000726)1.75347026
120Ocular albinism (HP:0001107)1.74407213
121Hematochezia (HP:0002573)1.72695174
122Abnormality of the periventricular white matter (HP:0002518)1.72232533
123* Diminished motivation (HP:0000745)1.71253654
124Tetraparesis (HP:0002273)1.69488726
125Stomatitis (HP:0010280)1.68926870
126Polyneuropathy (HP:0001271)1.68770448
127Flared iliac wings (HP:0002869)1.68589420
128Bone cyst (HP:0012062)1.65564765
129Hypoplasia of the odontoid process (HP:0003311)1.64432503
130Abnormality of transition element cation homeostasis (HP:0011030)1.64133497
131Conjunctival telangiectasia (HP:0000524)1.63655362
132Retrobulbar optic neuritis (HP:0100654)1.63455773
133Optic neuritis (HP:0100653)1.63455773
134White forelock (HP:0002211)1.63302896
135Progressive visual loss (HP:0000529)1.63164184
136Mucosal telangiectasiae (HP:0100579)1.62755426
137Malnutrition (HP:0004395)1.62752986
138* Apathy (HP:0000741)1.62485320
139Abnormality of aromatic amino acid family metabolism (HP:0004338)1.62144229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.00028314
2CDK124.35894337
3TGFBR24.11834081
4CSF1R3.16291158
5GRK52.86527890
6BLK2.79568288
7GRK62.70844190
8KIT2.25168697
9TRIB32.14262270
10MATK2.08586252
11PAK42.06166123
12RIPK41.92067759
13GRK71.91223424
14TBK11.90930368
15STK101.89723360
16MOS1.83024675
17IRAK41.82776413
18ADRBK21.80485718
19TYK21.69557575
20BCKDK1.64445735
21GRK11.60910820
22CDC42BPA1.57131899
23IRAK31.55980944
24RIPK11.44897210
25ACVR1B1.41498123
26PDK21.40945387
27SCYL21.40837990
28LIMK11.40772728
29CSK1.40676200
30TAOK31.33334226
31IKBKB1.33127628
32MAP4K11.31393760
33PRKG21.29888018
34MAP2K31.29422908
35MAPK71.28286864
36PIM21.25502988
37ZAP701.22211707
38MAP2K61.17012887
39TESK21.15700729
40FRK1.14093915
41MAPKAPK31.09769257
42PKN21.07920152
43NME21.01969093
44MYLK1.01603037
45CAMK1D1.01446315
46MAP3K141.01317443
47MST1R0.99977680
48HCK0.99013174
49PRKD20.98130315
50BMX0.96201739
51CAMKK20.93649908
52MAP3K30.93425791
53BMPR20.92102200
54HIPK20.90067964
55TXK0.88646634
56MAP3K10.87718909
57PDPK10.86866360
58NTRK10.86117443
59JAK10.82918788
60TTN0.82009396
61PRPF4B0.80604848
62JAK30.79927832
63FGFR30.79873346
64SYK0.78991380
65ITK0.75693845
66JAK20.74226380
67TTK0.74092021
68FER0.73964580
69EPHB10.72946103
70CSNK1G30.72794008
71LYN0.71028974
72LRRK20.70754828
73BTK0.70508602
74PRKCD0.70370211
75FLT30.69537001
76CAMK40.69139957
77TAOK10.66383749
78ABL20.65683251
79NEK90.65389651
80FES0.64689044
81MAPK110.64220153
82MET0.63693511
83LCK0.61547232
84WNK10.58857652
85CSNK1A1L0.58856469
86TYRO30.58832886
87PDK10.57062972
88CDK70.56750293
89CDK60.55854314
90IKBKE0.55667278
91IGF1R0.55601276
92EPHA20.55468281
93RPS6KA40.55059023
94IRAK10.54950158
95PTK60.54428708
96PDGFRA0.53582724
97CHUK0.53525237
98EPHA30.53289704
99EGFR0.52048995
100SIK10.50882720
101TEC0.50621057
102FGFR40.49869482
103MAP3K100.49701400
104DAPK30.48854096
105KDR0.48804098
106PIM10.47219304
107RPS6KA20.47115948
108MAP3K20.45551010
109ICK0.45280259
110IRAK20.44860852
111MARK30.44327767
112MAP4K20.43963648
113CLK10.43732437
114EIF2AK20.43333257
115DAPK20.42827689
116TESK10.42462320
117PINK10.41592426
118ARAF0.41317086
119FGR0.39393524
120ABL10.39202425
121TGFBR10.38945275
122PTK20.38037134
123ADRBK10.36996687
124MAP3K130.36277441
125MAPK120.36061675
126TRPM70.35975029
127CAMKK10.33798044
128MAPKAPK20.33795350
129DDR20.33419996
130PAK10.31859958
131ALK0.31384370
132TAOK20.29785307
133MAP3K110.29507942
134PIK3CG0.28500781
135EIF2AK30.28291947
136GSK3A0.25464759
137INSR0.25443256
138PAK20.24359916

Predicted pathways (KEGG)

RankGene SetZ-score
1* Glycosaminoglycan degradation_Homo sapiens_hsa005314.16674722
2* Lysosome_Homo sapiens_hsa041424.13421279
3* Other glycan degradation_Homo sapiens_hsa005113.49611451
4Staphylococcus aureus infection_Homo sapiens_hsa051503.40178381
5Leishmaniasis_Homo sapiens_hsa051402.76344693
6* Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.73870384
7Galactose metabolism_Homo sapiens_hsa000522.10491383
8Phagosome_Homo sapiens_hsa041452.08088174
9Pertussis_Homo sapiens_hsa051332.04921872
10Legionellosis_Homo sapiens_hsa051342.04903962
11Tuberculosis_Homo sapiens_hsa051522.02689964
12Osteoclast differentiation_Homo sapiens_hsa043802.01338634
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.95600545
14Allograft rejection_Homo sapiens_hsa053301.90320114
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86303433
16Fructose and mannose metabolism_Homo sapiens_hsa000511.82909608
17Malaria_Homo sapiens_hsa051441.82203681
18Antigen processing and presentation_Homo sapiens_hsa046121.75274768
19Autoimmune thyroid disease_Homo sapiens_hsa053201.62074452
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.57307730
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51130167
22Vitamin B6 metabolism_Homo sapiens_hsa007501.49637427
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.47790709
24Rheumatoid arthritis_Homo sapiens_hsa053231.47484794
25* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.46943427
26Type I diabetes mellitus_Homo sapiens_hsa049401.46573351
27Complement and coagulation cascades_Homo sapiens_hsa046101.45387002
28Arachidonic acid metabolism_Homo sapiens_hsa005901.44685333
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.43295468
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42530550
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42237167
32Apoptosis_Homo sapiens_hsa042101.38891411
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38016272
34B cell receptor signaling pathway_Homo sapiens_hsa046621.32588285
35Sulfur metabolism_Homo sapiens_hsa009201.30775098
36Toxoplasmosis_Homo sapiens_hsa051451.18838002
37Renin-angiotensin system_Homo sapiens_hsa046141.16119613
38Salmonella infection_Homo sapiens_hsa051321.09428868
39Measles_Homo sapiens_hsa051621.08474804
40Influenza A_Homo sapiens_hsa051641.08314782
41Fatty acid elongation_Homo sapiens_hsa000621.04140771
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03717322
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.03447241
44Hematopoietic cell lineage_Homo sapiens_hsa046401.00602612
45Sphingolipid metabolism_Homo sapiens_hsa006000.98530554
46Prion diseases_Homo sapiens_hsa050200.98145321
47Glutathione metabolism_Homo sapiens_hsa004800.97843495
48Shigellosis_Homo sapiens_hsa051310.96817634
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96340187
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92431294
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86069260
52PPAR signaling pathway_Homo sapiens_hsa033200.85104134
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84808406
54Acute myeloid leukemia_Homo sapiens_hsa052210.83582603
55TNF signaling pathway_Homo sapiens_hsa046680.83082967
56Herpes simplex infection_Homo sapiens_hsa051680.82867334
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82620131
58* Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82570780
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80726961
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76171995
61Collecting duct acid secretion_Homo sapiens_hsa049660.74469435
62Pentose phosphate pathway_Homo sapiens_hsa000300.74272150
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74050296
64Tryptophan metabolism_Homo sapiens_hsa003800.72421935
65Amoebiasis_Homo sapiens_hsa051460.70518753
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70503907
67mTOR signaling pathway_Homo sapiens_hsa041500.69421236
68N-Glycan biosynthesis_Homo sapiens_hsa005100.69337363
69Pancreatic cancer_Homo sapiens_hsa052120.69164151
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68574760
71Caffeine metabolism_Homo sapiens_hsa002320.68178852
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.67665183
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67524549
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.66517456
75Vibrio cholerae infection_Homo sapiens_hsa051100.65501187
76Chemokine signaling pathway_Homo sapiens_hsa040620.64821861
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64344450
78Endocytosis_Homo sapiens_hsa041440.60115710
79Proteoglycans in cancer_Homo sapiens_hsa052050.58578526
80Chronic myeloid leukemia_Homo sapiens_hsa052200.57897937
81Asthma_Homo sapiens_hsa053100.57852906
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57605965
83African trypanosomiasis_Homo sapiens_hsa051430.57246028
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57245977
85Hepatitis B_Homo sapiens_hsa051610.56534720
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56254540
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.55162763
88Hepatitis C_Homo sapiens_hsa051600.54395639
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54051769
90Platelet activation_Homo sapiens_hsa046110.53583985
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.53318897
92Linoleic acid metabolism_Homo sapiens_hsa005910.52779135
93Graft-versus-host disease_Homo sapiens_hsa053320.51477304
94Regulation of autophagy_Homo sapiens_hsa041400.48768755
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47375556
96Bladder cancer_Homo sapiens_hsa052190.47011007
97Starch and sucrose metabolism_Homo sapiens_hsa005000.46209770
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45462720
99Peroxisome_Homo sapiens_hsa041460.43654193
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.43540879
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.40763508
102Thyroid cancer_Homo sapiens_hsa052160.40321464
103HIF-1 signaling pathway_Homo sapiens_hsa040660.37689609
104Fatty acid degradation_Homo sapiens_hsa000710.36931291
105Focal adhesion_Homo sapiens_hsa045100.36914207
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36884430
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.36528744
108Chemical carcinogenesis_Homo sapiens_hsa052040.36239341
109Insulin resistance_Homo sapiens_hsa049310.36110628
110Fatty acid metabolism_Homo sapiens_hsa012120.34832996
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.34667907
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33961784
113ABC transporters_Homo sapiens_hsa020100.33568251
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33183303
115Folate biosynthesis_Homo sapiens_hsa007900.31453599
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.31449956
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31350450
118VEGF signaling pathway_Homo sapiens_hsa043700.30680967
119Mineral absorption_Homo sapiens_hsa049780.29473028
120Ether lipid metabolism_Homo sapiens_hsa005650.29266538
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.28959860
122Viral myocarditis_Homo sapiens_hsa054160.28907862
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28277503
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24937761
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22905229
126Tyrosine metabolism_Homo sapiens_hsa003500.21143499
127Vitamin digestion and absorption_Homo sapiens_hsa049770.18728626

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