HES7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1replicative senescence (GO:0090399)8.72034337
2sulfation (GO:0051923)8.05100285
3neuron remodeling (GO:0016322)7.51185604
4glucosamine-containing compound catabolic process (GO:1901072)7.32917751
5hematopoietic stem cell proliferation (GO:0071425)6.75267518
6viral mRNA export from host cell nucleus (GO:0046784)6.44109063
7regulation of DNA damage checkpoint (GO:2000001)6.38959858
8DNA integration (GO:0015074)6.33348145
9regulation of B cell receptor signaling pathway (GO:0050855)6.01886493
10heparan sulfate proteoglycan biosynthetic process (GO:0015012)6.01328699
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.63818408
12mitochondrial respiratory chain complex I assembly (GO:0032981)5.63818408
13NADH dehydrogenase complex assembly (GO:0010257)5.63818408
14negative regulation of calcium ion transport into cytosol (GO:0010523)5.30854408
15modulation by virus of host process (GO:0019054)5.24274198
16negative regulation of catenin import into nucleus (GO:0035414)5.20185480
17oligosaccharide catabolic process (GO:0009313)4.96606336
18negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.83732541
19negative regulation of translation, ncRNA-mediated (GO:0040033)4.83732541
20regulation of translation, ncRNA-mediated (GO:0045974)4.83732541
21positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)4.82650119
22regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)4.82650119
23regulation of endothelial cell differentiation (GO:0045601)4.82192111
24positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.58623531
25epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.50411910
26positive regulation of systemic arterial blood pressure (GO:0003084)4.48549509
27positive regulation of mitochondrial membrane permeability (GO:0035794)4.43320420
28modulation by symbiont of host cellular process (GO:0044068)4.42302308
29positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO4.40694588
30regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)4.40694588
31glomerular visceral epithelial cell development (GO:0072015)4.33650478
32cAMP biosynthetic process (GO:0006171)4.33276943
33positive regulation of cardiac muscle cell differentiation (GO:2000727)4.33191561
34cardiac muscle hypertrophy (GO:0003300)4.31595035
35cardiac muscle hypertrophy in response to stress (GO:0014898)4.27559349
36muscle hypertrophy in response to stress (GO:0003299)4.27559349
37cardiac muscle adaptation (GO:0014887)4.27559349
38positive regulation of mRNA 3-end processing (GO:0031442)4.27480328
39opioid receptor signaling pathway (GO:0038003)4.27235780
40amino sugar catabolic process (GO:0046348)4.27101183
41lymphangiogenesis (GO:0001946)4.25625525
42positive regulation of action potential (GO:0045760)4.22085026
43DNA replication-dependent nucleosome assembly (GO:0006335)4.19818972
44DNA replication-dependent nucleosome organization (GO:0034723)4.19818972
45activation of protein kinase A activity (GO:0034199)4.18239136
46RNA destabilization (GO:0050779)4.17904457
47striated muscle hypertrophy (GO:0014897)4.07190628
483-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.99619777
49purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.99619777
50regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.98092658
51sulfate transmembrane transport (GO:1902358)3.94274091
52regulation of mRNA 3-end processing (GO:0031440)3.87135589
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83840143
54adrenergic receptor signaling pathway (GO:0071875)3.82827719
55positive regulation of cAMP-mediated signaling (GO:0043950)3.79844432
56positive regulation by organism of defense response of other organism involved in symbiotic interact3.76289678
57modulation by symbiont of host immune response (GO:0052553)3.76289678
58positive regulation by symbiont of host defense response (GO:0052509)3.76289678
59modulation by symbiont of host defense response (GO:0052031)3.76289678
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.76289678
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.76289678
62regulation of histone H3-K27 methylation (GO:0061085)3.75600579
63negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.74846664
64spleen development (GO:0048536)3.71240310
65protein complex biogenesis (GO:0070271)3.70511602
66proteoglycan biosynthetic process (GO:0030166)3.69792673
67glomerular epithelial cell development (GO:0072310)3.68145372
68T cell mediated immunity (GO:0002456)3.67883492
69pharyngeal system development (GO:0060037)3.67643803
70transepithelial transport (GO:0070633)3.67040561
71polyol transport (GO:0015791)3.65363020
72otic vesicle formation (GO:0030916)3.64570963
73sperm capacitation (GO:0048240)3.62518698
74positive regulation of mRNA catabolic process (GO:0061014)3.62433315
75positive regulation of protein homooligomerization (GO:0032464)3.60883355
76positive regulation of microtubule polymerization (GO:0031116)3.57759093
77interferon-gamma secretion (GO:0072643)3.56364858
78muscle hypertrophy (GO:0014896)3.56246958
79regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.53359030
80cell proliferation in forebrain (GO:0021846)3.53010279
81positive regulation of digestive system process (GO:0060456)3.50849054
82positive regulation of fatty acid oxidation (GO:0046321)3.47234616
83mesonephros development (GO:0001823)3.47159506
84lipopolysaccharide biosynthetic process (GO:0009103)3.44524614
85microglial cell activation (GO:0001774)3.43819607
86regulation of cardiac muscle cell contraction (GO:0086004)3.41481750
87mitochondrial respiratory chain complex assembly (GO:0033108)3.40354306
88positive regulation of fatty acid beta-oxidation (GO:0032000)3.39902137
89negative regulation of systemic arterial blood pressure (GO:0003085)3.39843015
90anterior/posterior axis specification, embryo (GO:0008595)3.39461021
91regulation of actin filament-based movement (GO:1903115)3.37677008
92heparan sulfate proteoglycan metabolic process (GO:0030201)3.37584448
93sulfate transport (GO:0008272)3.37104864
94prostate gland growth (GO:0060736)3.34625316
95positive regulation of heart rate (GO:0010460)3.33078901
96lung morphogenesis (GO:0060425)3.33028297
97positive regulation of protein oligomerization (GO:0032461)3.32841969
98positive regulation of heat generation (GO:0031652)3.31551700
99flavonoid metabolic process (GO:0009812)3.28686280
100regulation of fever generation (GO:0031620)3.27510336
101G-protein coupled receptor internalization (GO:0002031)3.26390131
102developmental pigmentation (GO:0048066)3.23620675
103lipopolysaccharide metabolic process (GO:0008653)3.21489830
104adult heart development (GO:0007512)3.20041708
105striated muscle adaptation (GO:0014888)3.16446107
106hyaluronan catabolic process (GO:0030214)3.15146077
107regulation of tight junction assembly (GO:2000810)3.14708317
108positive regulation of mRNA processing (GO:0050685)3.13898927
109modulation by virus of host morphology or physiology (GO:0019048)3.11810342
110regulation of germinal center formation (GO:0002634)3.10391845
111B cell homeostasis (GO:0001782)3.09998857
112positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.09703612
113membrane protein ectodomain proteolysis (GO:0006509)3.09001851
114dermatan sulfate biosynthetic process (GO:0030208)3.08145644
115regulation of mRNA catabolic process (GO:0061013)3.04225409
116protein kinase C signaling (GO:0070528)3.03745007
117positive regulation of toll-like receptor signaling pathway (GO:0034123)3.02760333
118positive regulation of interleukin-1 beta secretion (GO:0050718)3.02694638
119detection of calcium ion (GO:0005513)3.02631090
120positive regulation of prostaglandin secretion (GO:0032308)3.02506121
121response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.01258376
122cellular response to virus (GO:0098586)3.00964657
123negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.00604596
124regulation of DNA endoreduplication (GO:0032875)3.00404611
125lymph node development (GO:0048535)3.00389963
126positive regulation of muscle hypertrophy (GO:0014742)2.99680330
127positive regulation of cardiac muscle hypertrophy (GO:0010613)2.99680330
128regulation of urine volume (GO:0035809)2.97730437
129response to methylmercury (GO:0051597)2.97527074
130cellular potassium ion homeostasis (GO:0030007)2.97050305
131positive regulation of RNA splicing (GO:0033120)2.95967153
132relaxation of cardiac muscle (GO:0055119)2.95493372
133sphingoid metabolic process (GO:0046519)2.94967107
134response to UV-C (GO:0010225)2.92558855
135protein-chromophore linkage (GO:0018298)2.92456500
136glomerular basement membrane development (GO:0032836)2.90535483
137gland morphogenesis (GO:0022612)2.90385805
138regulation of skeletal muscle contraction (GO:0014819)2.89457376
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.89430402
140glycoprotein biosynthetic process (GO:0009101)2.88464665
141regulation of phospholipid biosynthetic process (GO:0071071)2.87611358
142positive regulation of potassium ion transmembrane transport (GO:1901381)2.87489811
143neuronal action potential (GO:0019228)2.87165674
144regulation of cardiac muscle cell differentiation (GO:2000725)2.85357837
145white fat cell differentiation (GO:0050872)2.84905389
146negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.84655670
147trophoblast giant cell differentiation (GO:0060707)2.84064287
148embryonic hindlimb morphogenesis (GO:0035116)2.82620641
149response to pheromone (GO:0019236)2.81749807
150cartilage morphogenesis (GO:0060536)2.81534669
151regulation of heat generation (GO:0031650)2.80657053
152negative regulation of fibrinolysis (GO:0051918)2.79780793
153peristalsis (GO:0030432)2.79694434
154regulation of sequestering of triglyceride (GO:0010889)2.79467163
155regulation of cell proliferation involved in kidney development (GO:1901722)2.79213486
156cellular response to exogenous dsRNA (GO:0071360)2.78329266
157protein prenylation (GO:0018342)2.78178240
158prenylation (GO:0097354)2.78178240
159regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.75926486
160positive regulation of interleukin-1 secretion (GO:0050716)2.75315002
161DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.74473135
162release of cytochrome c from mitochondria (GO:0001836)2.74191928
163labyrinthine layer development (GO:0060711)2.73093022
164dermatan sulfate metabolic process (GO:0030205)2.72421418
165righting reflex (GO:0060013)2.71131408
166post-embryonic morphogenesis (GO:0009886)2.71046268
167G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.70902808
168positive regulation of mRNA metabolic process (GO:1903313)2.70504800
169cellular response to glucose starvation (GO:0042149)2.70194463
170response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70078208
171response to host immune response (GO:0052572)2.70078208
172ear development (GO:0043583)2.69041955
173innate immune response in mucosa (GO:0002227)2.68631658
174forebrain neuron development (GO:0021884)2.67595226
175neuron maturation (GO:0042551)2.66768519
176plasma membrane repair (GO:0001778)2.66618088
177modification by symbiont of host morphology or physiology (GO:0044003)2.66474432
178relaxation of smooth muscle (GO:0044557)2.66347813
179detection of molecule of bacterial origin (GO:0032490)2.64362677
180tryptophan metabolic process (GO:0006568)2.64360527
181branching involved in labyrinthine layer morphogenesis (GO:0060670)2.64282578
182regulation of mitochondrial membrane permeability (GO:0046902)2.63684047
183response to lipoprotein particle (GO:0055094)2.58688558
184regulation of interleukin-1 beta secretion (GO:0050706)2.58305794
185neutrophil mediated immunity (GO:0002446)2.57133517
186L-amino acid import (GO:0043092)2.56788039
187regulation of prostaglandin secretion (GO:0032306)2.56342033
188heparin metabolic process (GO:0030202)10.7943923
189heparin biosynthetic process (GO:0030210)10.7943923

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.24485556
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.97270283
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.60959884
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.54517018
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.52399536
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.93030501
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.89354162
8CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.84957006
9* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.84726209
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.73792694
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41617290
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37713842
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.36880097
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.35912065
15GATA1_22025678_ChIP-Seq_K562_Human2.35123622
16CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.17235706
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.11529755
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07598782
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.02137592
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97145520
21GBX2_23144817_ChIP-Seq_PC3_Human1.94553016
22POU5F1_16153702_ChIP-ChIP_HESCs_Human1.86672517
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.85303016
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.76099730
25IRF1_19129219_ChIP-ChIP_H3396_Human1.75894801
26PKCTHETA_26484144_Chip-Seq_BREAST_Human1.74671796
27SCL_19346495_ChIP-Seq_HPC-7_Human1.72137638
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.69780571
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.68406336
30EZH2_22144423_ChIP-Seq_EOC_Human1.67017633
31* STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65092742
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64394651
33LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63356336
34* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62552430
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61357389
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.57917187
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.57506407
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55837100
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55766559
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55400098
41CDX2_20551321_ChIP-Seq_CACO-2_Human1.55078982
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54043285
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.49825548
44GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.49404109
45* AR_21572438_ChIP-Seq_LNCaP_Human1.49252510
46* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47370691
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43188535
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40995649
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40453939
50RUNX1_27457419_Chip-Seq_LIVER_Mouse1.39011423
51* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36687886
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34849547
53TP53_16413492_ChIP-PET_HCT116_Human1.34687558
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.33049450
55* EED_16625203_ChIP-ChIP_MESCs_Mouse1.32786865
56P53_22387025_ChIP-Seq_ESCs_Mouse1.32757699
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.32577817
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31651720
59* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31504111
60* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31504111
61STAT3_18555785_Chip-Seq_ESCs_Mouse1.31276365
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.30100416
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30051341
64RNF2_27304074_Chip-Seq_NSC_Mouse1.30016133
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29311574
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.28939610
67SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28169551
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.27933379
69FUS_26573619_Chip-Seq_HEK293_Human1.27809465
70OCT4_18555785_Chip-Seq_ESCs_Mouse1.27708798
71* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27270255
72* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.26224647
73P300_18555785_Chip-Seq_ESCs_Mouse1.24711325
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.24424110
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24095733
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23017121
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.22154471
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.21490416
79PU1_27457419_Chip-Seq_LIVER_Mouse1.18680493
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.17668747
81NMYC_18555785_Chip-Seq_ESCs_Mouse1.15928303
82TDRD3_21172665_ChIP-Seq_MCF-7_Human1.15656759
83RXR_22108803_ChIP-Seq_LS180_Human1.14538483
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.13742253
85PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13149575
86* CBX2_27304074_Chip-Seq_ESCs_Mouse1.12948731
87EWS_26573619_Chip-Seq_HEK293_Human1.11315230
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09718379
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09299177
90ZFX_18555785_Chip-Seq_ESCs_Mouse1.09089996
91ESR1_21235772_ChIP-Seq_MCF-7_Human1.08475338
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08357318
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08087770
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.07531634
95POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07382652
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07167504
97ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05967406
98* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05513139
99SOX2_16153702_ChIP-ChIP_HESCs_Human1.05398483
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04968116
101SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04817673
102ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02891332
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02647946
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01956349
105SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01360323
106BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01254944
107AHR_22903824_ChIP-Seq_MCF-7_Human1.01184960
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00116098
109VDR_24787735_ChIP-Seq_THP-1_Human0.99691638
110MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97564993
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97234528
112SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97232379
113SOX2_18555785_Chip-Seq_ESCs_Mouse0.97069334
114CJUN_26792858_Chip-Seq_BT549_Human0.96854938
115JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96430756
116* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95418933
117STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95355750
118STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.94669704
119GF1_26923725_Chip-Seq_HPCs_Mouse0.94447793
120STAT1_20625510_ChIP-Seq_HELA_Human0.94435459
121P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94344580
122* RNF2_27304074_Chip-Seq_ESCs_Mouse0.93791664
123CTCF_18555785_Chip-Seq_ESCs_Mouse0.93395163
124VDR_22108803_ChIP-Seq_LS180_Human0.93032054
125VDR_21846776_ChIP-Seq_THP-1_Human0.92801587
126EZH2_27304074_Chip-Seq_ESCs_Mouse0.92758817
127P300_19829295_ChIP-Seq_ESCs_Human0.92337655
128FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92074077
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91726167
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91702656
131RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91343550
132* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90923932
133* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.86941546
134* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85751204
135* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85020428
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81030917
137ELK4_26923725_Chip-Seq_MESODERM_Mouse0.80926451
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.80606277
139FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.79619971
140* TP53_20018659_ChIP-ChIP_R1E_Mouse0.78554949
141GF1B_26923725_Chip-Seq_HPCs_Mouse0.78346782
142PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77820068
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.73823028
144* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.72226099
145* UBF1/2_26484160_Chip-Seq_HMECs_Human0.71790945
146* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.69620382
147FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.68436378
148GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66548047
149TP53_18474530_ChIP-ChIP_U2OS_Human0.65770358
150CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.65167723
151SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64659939
152RUNX1_27514584_Chip-Seq_MCF-7_Human0.63534737
153VDR_24763502_ChIP-Seq_THP-1_Human0.62309126
154* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.61732143
155LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.61454190
156* RING1B_27294783_Chip-Seq_ESCs_Mouse0.61084622
157* EZH2_27294783_Chip-Seq_ESCs_Mouse0.60900254
158FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.60378291
159GATA1_19941826_ChIP-Seq_K562_Human0.60284770
160AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.58983020
161* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.58129516
162* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.58097070
163* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.57591637
164ESR2_21235772_ChIP-Seq_MCF-7_Human0.56627673
165ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.55668246
166YY1_22570637_ChIP-Seq_MALME-3M_Human0.55565420
167GATA2_19941826_ChIP-Seq_K562_Human0.54310426
168FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.54128528
169TP53_23651856_ChIP-Seq_MEFs_Mouse0.52557185
170NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.52189486
171KDM2B_26808549_Chip-Seq_REH_Human0.52000174
172FOXA2_19822575_ChIP-Seq_HepG2_Human0.50691809
173* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.49775671

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol4.36650044
2MP0005257_abnormal_intraocular_pressure4.26832989
3MP0005360_urolithiasis4.24851688
4MP0003183_abnormal_peptide_metabolism3.27565219
5MP0002138_abnormal_hepatobiliary_system3.23275466
6MP0005310_abnormal_salivary_gland3.14402973
7MP0000750_abnormal_muscle_regeneration3.08753809
8MP0000751_myopathy2.88642366
9MP0002277_abnormal_respiratory_mucosa2.85736742
10MP0009046_muscle_twitch2.84180623
11MP0006082_CNS_inflammation2.75526657
12MP0010368_abnormal_lymphatic_system2.74631538
13MP0004510_myositis2.72911483
14MP0000749_muscle_degeneration2.55284762
15MP0003941_abnormal_skin_development2.50026096
16MP0004272_abnormal_basement_membrane2.48733607
17MP0005197_abnormal_uvea_morphology2.47338314
18MP0002160_abnormal_reproductive_system2.45640265
19MP0009384_cardiac_valve_regurgitation2.41351139
20MP0001879_abnormal_lymphatic_vessel2.40774570
21MP0000566_synostosis2.38921456
22MP0003693_abnormal_embryo_hatching2.38279102
23MP0003828_pulmonary_edema2.37068688
24MP0004130_abnormal_muscle_cell2.36525313
25MP0003172_abnormal_lysosome_physiology2.34019816
26MP0000013_abnormal_adipose_tissue2.32676126
27MP0008961_abnormal_basal_metabolism2.32019961
28MP0003191_abnormal_cellular_cholesterol2.30659658
29MP0006292_abnormal_olfactory_placode2.25230354
30MP0004134_abnormal_chest_morphology2.21229455
31MP0000049_abnormal_middle_ear2.18049501
32MP0008872_abnormal_physiological_respon2.10403872
33MP0003136_yellow_coat_color2.09628771
34MP0009250_abnormal_appendicular_skeleto1.99660161
35MP0000747_muscle_weakness1.99648641
36MP0000613_abnormal_salivary_gland1.99550640
37MP0001346_abnormal_lacrimal_gland1.99321363
38MP0002396_abnormal_hematopoietic_system1.91254491
39MP0000767_abnormal_smooth_muscle1.89648830
40MP0000678_abnormal_parathyroid_gland1.87148678
41MP0009780_abnormal_chondrocyte_physiolo1.82505790
42MP0005670_abnormal_white_adipose1.81442066
43MP0002009_preneoplasia1.79253475
44MP0002139_abnormal_hepatobiliary_system1.76732275
45MP0002896_abnormal_bone_mineralization1.76391434
46MP0003221_abnormal_cardiomyocyte_apopto1.74591098
47MP0000733_abnormal_muscle_development1.73426405
48MP0002089_abnormal_postnatal_growth/wei1.71511432
49MP0005503_abnormal_tendon_morphology1.67781862
50MP0000015_abnormal_ear_pigmentation1.67139365
51MP0004145_abnormal_muscle_electrophysio1.66881358
52MP0002127_abnormal_cardiovascular_syste1.66468902
53MP0009697_abnormal_copulation1.65523890
54MP0001800_abnormal_humoral_immune1.60615070
55MP0001661_extended_life_span1.60435802
56MP0003279_aneurysm1.59764035
57MP0005275_abnormal_skin_tensile1.59543591
58MP0002452_abnormal_antigen_presenting1.55849817
59MP0004185_abnormal_adipocyte_glucose1.54032427
60MP0002971_abnormal_brown_adipose1.50074114
61MP0002108_abnormal_muscle_morphology1.49818515
62MP0002106_abnormal_muscle_physiology1.49171649
63MP0001851_eye_inflammation1.49027396
64MP0005508_abnormal_skeleton_morphology1.48567936
65MP0002933_joint_inflammation1.48428016
66MP0001544_abnormal_cardiovascular_syste1.48239522
67MP0005385_cardiovascular_system_phenoty1.48239522
68MP0000003_abnormal_adipose_tissue1.45104610
69MP0003091_abnormal_cell_migration1.44402267
70MP0002332_abnormal_exercise_endurance1.43818575
71MP0005379_endocrine/exocrine_gland_phen1.42991016
72MP0003787_abnormal_imprinting1.42709329
73MP0005171_absent_coat_pigmentation1.41165124
74MP0004087_abnormal_muscle_fiber1.39908473
75MP0008438_abnormal_cutaneous_collagen1.38025385
76MP0005369_muscle_phenotype1.36552547
77MP0000371_diluted_coat_color1.35620318
78MP0003656_abnormal_erythrocyte_physiolo1.35574282
79MP0005409_darkened_coat_color1.34888084
80MP0003436_decreased_susceptibility_to1.34429919
81MP0002723_abnormal_immune_serum1.33343838
82MP0004215_abnormal_myocardial_fiber1.33281118
83MP0000920_abnormal_myelination1.32149636
84MP0002693_abnormal_pancreas_physiology1.29728130
85MP0005620_abnormal_muscle_contractility1.27906093
86MP0002419_abnormal_innate_immunity1.27269702
87MP0002972_abnormal_cardiac_muscle1.25235010
88MP0004381_abnormal_hair_follicle1.24852953
89MP0005000_abnormal_immune_tolerance1.24647977
90MP0002163_abnormal_gland_morphology1.24211140
91MP0003252_abnormal_bile_duct1.23642829
92MP0001881_abnormal_mammary_gland1.23259448
93MP0005390_skeleton_phenotype1.22448097
94MP0003646_muscle_fatigue1.22278408
95MP0001188_hyperpigmentation1.21978963
96MP0000569_abnormal_digit_pigmentation1.20774473
97MP0002102_abnormal_ear_morphology1.20747643
98MP0003045_fibrosis1.19753531
99MP0002269_muscular_atrophy1.19695837
100MP0005076_abnormal_cell_differentiation1.19686968
101MP0002295_abnormal_pulmonary_circulatio1.18322808
102MP0001286_abnormal_eye_development1.18130983
103MP0006138_congestive_heart_failure1.18033899
104MP0004036_abnormal_muscle_relaxation1.17924050
105MP0005410_abnormal_fertilization1.16449383
106MP0005389_reproductive_system_phenotype1.14349292
107MP0000759_abnormal_skeletal_muscle1.13635575
108MP0004233_abnormal_muscle_weight1.12546305
109MP0000372_irregular_coat_pigmentation1.11547169
110MP0004484_altered_response_of1.11116406
111MP0005464_abnormal_platelet_physiology1.09643552
112MP0005334_abnormal_fat_pad1.09593394
113MP0009764_decreased_sensitivity_to1.09418756
114MP0001819_abnormal_immune_cell1.08825790
115MP0003011_delayed_dark_adaptation1.08425586
116MP0002420_abnormal_adaptive_immunity1.07996606
117MP0002638_abnormal_pupillary_reflex1.07679059
118MP0001502_abnormal_circadian_rhythm1.07498335
119MP0002998_abnormal_bone_remodeling1.06137696
120MP0001873_stomach_inflammation1.05510178
121MP0001485_abnormal_pinna_reflex1.03497662
122MP0003868_abnormal_feces_composition1.02720636
123MP0004264_abnormal_extraembryonic_tissu1.01724248
124MP0008569_lethality_at_weaning1.01353988
125MP0003959_abnormal_lean_body1.00328481
126MP0009115_abnormal_fat_cell0.99080867
127MP0001440_abnormal_grooming_behavior0.98418311
128MP0001835_abnormal_antigen_presentation0.97385696
129MP0005423_abnormal_somatic_nervous0.96166129
130MP0005387_immune_system_phenotype0.93482962
131MP0001790_abnormal_immune_system0.93482962
132MP0001324_abnormal_eye_pigmentation0.93235767
133MP0000703_abnormal_thymus_morphology0.91525731
134MP0000465_gastrointestinal_hemorrhage0.90730999
135MP0009379_abnormal_foot_pigmentation0.89827271
136MP0004085_abnormal_heartbeat0.89304240
137MP0005365_abnormal_bile_salt0.88604253
138MP0003448_altered_tumor_morphology0.88513935
139MP0002116_abnormal_craniofacial_bone0.88276704
140MP0005671_abnormal_response_to0.88132605
141MP0004147_increased_porphyrin_level0.87190256
142MP0000716_abnormal_immune_system0.86539457
143MP0001986_abnormal_taste_sensitivity0.86459796
144* MP0000163_abnormal_cartilage_morphology0.83121122
145MP0002928_abnormal_bile_duct0.83068009
146MP0001486_abnormal_startle_reflex0.81627448
147MP0003755_abnormal_palate_morphology0.80507278
148MP0001944_abnormal_pancreas_morphology0.80337253
149* MP0002113_abnormal_skeleton_development0.79968655
150MP0005083_abnormal_biliary_tract0.79774566
151MP0001849_ear_inflammation0.78945859
152MP0001663_abnormal_digestive_system0.77956217
153MP0000428_abnormal_craniofacial_morphol0.77185346
154MP0000762_abnormal_tongue_morphology0.77115071
155MP0010094_abnormal_chromosome_stability0.75845622
156* MP0002111_abnormal_tail_morphology0.75442704
157MP0002109_abnormal_limb_morphology0.75015201
158MP0002090_abnormal_vision0.74685843
159MP0003950_abnormal_plasma_membrane0.73846599
160MP0005375_adipose_tissue_phenotype0.73487152
161MP0002722_abnormal_immune_system0.73473396
162MP0005193_abnormal_anterior_eye0.73190385
163* MP0002114_abnormal_axial_skeleton0.72387658
164MP0005166_decreased_susceptibility_to0.69853756
165MP0002148_abnormal_hypersensitivity_rea0.69812922
166MP0004084_abnormal_cardiac_muscle0.69510737
167MP0002075_abnormal_coat/hair_pigmentati0.69239079
168MP0004142_abnormal_muscle_tone0.69235664
169MP0000432_abnormal_head_morphology0.68997646
170MP0005085_abnormal_gallbladder_physiolo0.67938901
171MP0003937_abnormal_limbs/digits/tail_de0.66387668
172MP0002398_abnormal_bone_marrow0.65248366
173MP0004885_abnormal_endolymph0.65046657
174MP0005451_abnormal_body_composition0.64577295
175MP0000383_abnormal_hair_follicle0.64015952
176MP0000467_abnormal_esophagus_morphology0.63175706
177MP0003567_abnormal_fetal_cardiomyocyte0.63164983
178MP0005220_abnormal_exocrine_pancreas0.63016840
179MP0003935_abnormal_craniofacial_develop0.62166612
180MP0005084_abnormal_gallbladder_morpholo0.61579261
181MP0005330_cardiomyopathy0.61491327
182MP0002249_abnormal_larynx_morphology0.59460409

Predicted human phenotypes

RankGene SetZ-score
1Pseudobulbar signs (HP:0002200)7.12663392
2Hemiplegia (HP:0002301)5.80182689
3Hepatocellular necrosis (HP:0001404)5.41877051
4Axonal loss (HP:0003447)5.08511490
5Short femoral neck (HP:0100864)5.00075872
6Rough bone trabeculation (HP:0100670)4.96326563
7Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)4.38754035
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.15947591
9Tubular atrophy (HP:0000092)4.09642387
10Hepatic necrosis (HP:0002605)4.04698646
11Calf muscle hypertrophy (HP:0008981)3.88060458
12Aortic regurgitation (HP:0001659)3.83679784
13Tongue fasciculations (HP:0001308)3.82836310
14Premature graying of hair (HP:0002216)3.77291986
15J-shaped sella turcica (HP:0002680)3.71555530
16Diastasis recti (HP:0001540)3.68176020
17Hematochezia (HP:0002573)3.65806595
18Chromsome breakage (HP:0040012)3.65139500
19Neonatal respiratory distress (HP:0002643)3.60338949
20Broad ribs (HP:0000885)3.60197873
21Muscle fibrillation (HP:0010546)3.55872475
22Deformed sella turcica (HP:0002681)3.55196468
23Carpal bone hypoplasia (HP:0001498)3.53124621
24Muscle hypertrophy of the lower extremities (HP:0008968)3.51464987
25Aplasia/hypoplasia of the femur (HP:0005613)3.50457132
26Vertebral arch anomaly (HP:0008438)3.48858039
27Aplasia/Hypoplasia involving the pelvis (HP:0009103)3.37706817
28Peripheral demyelination (HP:0011096)3.24679307
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.22297558
30Slow saccadic eye movements (HP:0000514)3.17224191
31Abnormality of the lumbar spine (HP:0100712)3.08063261
32Aplasia cutis congenita (HP:0001057)3.04569433
33Impaired smooth pursuit (HP:0007772)3.03025132
34Hydroxyprolinuria (HP:0003080)3.01203026
35Abnormality of proline metabolism (HP:0010907)3.01203026
36Dyschromatopsia (HP:0007641)2.99883350
37Recurrent bacterial skin infections (HP:0005406)2.99712940
38Duplicated collecting system (HP:0000081)2.99589288
39Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.98651656
40Short 4th metacarpal (HP:0010044)2.98651656
41Mesangial abnormality (HP:0001966)2.95488420
42Conjunctival hamartoma (HP:0100780)2.93662680
43Hypoproteinemia (HP:0003075)2.92038374
44Postural tremor (HP:0002174)2.92007059
45Recurrent abscess formation (HP:0002722)2.87700393
46Upper motor neuron abnormality (HP:0002127)2.85541133
47Genetic anticipation (HP:0003743)2.84531450
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.84460135
49Abnormal protein N-linked glycosylation (HP:0012347)2.84460135
50Abnormal protein glycosylation (HP:0012346)2.84460135
51Abnormal glycosylation (HP:0012345)2.84460135
52Hyporeflexia of lower limbs (HP:0002600)2.77287857
53Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.76442182
54Morphological abnormality of the pyramidal tract (HP:0002062)2.67792380
55Thoracolumbar scoliosis (HP:0002944)2.66659471
56Abnormality of the sella turcica (HP:0002679)2.65820682
57Progressive external ophthalmoplegia (HP:0000590)2.59730232
58Skin pits (HP:0100276)2.59475792
59Short phalanx of the thumb (HP:0009660)2.59048569
60Abnormality of the renal collecting system (HP:0004742)2.57488740
61Prostate neoplasm (HP:0100787)2.56009321
62Chronic hepatic failure (HP:0100626)2.55207684
63Thoracic kyphosis (HP:0002942)2.54182204
64Abnormality of ocular smooth pursuit (HP:0000617)2.48190801
65Hypergonadotropic hypogonadism (HP:0000815)2.47498154
66CNS demyelination (HP:0007305)2.46455356
67Tetraparesis (HP:0002273)2.43952513
68Fibular aplasia (HP:0002990)2.40709407
69Decreased central vision (HP:0007663)2.40261128
70Bile duct proliferation (HP:0001408)2.40102983
71Abnormal biliary tract physiology (HP:0012439)2.40102983
72Hamartoma of the eye (HP:0010568)2.39783553
73Oligodontia (HP:0000677)2.37938937
74Abnormality of DNA repair (HP:0003254)2.33815816
75Flared iliac wings (HP:0002869)2.33215105
76Abnormality of the calf musculature (HP:0001430)2.32149716
77Slender long bone (HP:0003100)2.30564375
78Chronic diarrhea (HP:0002028)2.29968184
79Neuronal loss in central nervous system (HP:0002529)2.29756036
80Recurrent skin infections (HP:0001581)2.27741944
81Patchy hypopigmentation of hair (HP:0011365)2.27615962
82Abnormality of polysaccharide metabolism (HP:0011012)2.27503087
83Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27503087
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27503087
85Type I transferrin isoform profile (HP:0003642)2.22663500
86Death in childhood (HP:0003819)2.21384154
87Recurrent pneumonia (HP:0006532)2.21379008
88Gliosis (HP:0002171)2.21238334
89Reduced antithrombin III activity (HP:0001976)2.18777581
90Difficulty running (HP:0009046)2.18677024
91Hypoplastic ischia (HP:0003175)2.18134038
92Febrile seizures (HP:0002373)2.16804010
93Recurrent cutaneous fungal infections (HP:0011370)2.14363807
94Chronic mucocutaneous candidiasis (HP:0002728)2.14363807
95Thick nail (HP:0001805)2.13947268
96Nonimmune hydrops fetalis (HP:0001790)2.12773304
97Submucous cleft hard palate (HP:0000176)2.12456370
98Flat acetabular roof (HP:0003180)2.11785541
99Abnormality of the frontal sinuses (HP:0002687)2.11321641
100Pathologic fracture (HP:0002756)2.09197873
101Thickened calvaria (HP:0002684)2.08441976
102Pendular nystagmus (HP:0012043)2.08235055
103Abnormality of the 4th metacarpal (HP:0010012)2.08135576
104Hypoplastic pelvis (HP:0008839)2.07710720
105Cavernous hemangioma (HP:0001048)2.06946368
106Ovoid vertebral bodies (HP:0003300)2.05944074
107Abnormal pancreas size (HP:0012094)2.04182662
108Amelogenesis imperfecta (HP:0000705)2.02363419
109Abnormality of the proximal phalanges of the hand (HP:0009834)2.02198743
110Abnormality of the nasal septum (HP:0000419)2.02028294
111Persistence of primary teeth (HP:0006335)2.00160368
112Oral leukoplakia (HP:0002745)11.3469460
113Eczematoid dermatitis (HP:0000976)1.99918383
114Urinary glycosaminoglycan excretion (HP:0003541)1.98548508
115Mucopolysacchariduria (HP:0008155)1.98548508
116Meningioma (HP:0002858)1.98435398
117Gastroesophageal reflux (HP:0002020)1.97866375
118Cheilitis (HP:0100825)1.96830063
119Urethral obstruction (HP:0000796)1.94760729
120Areflexia of lower limbs (HP:0002522)1.94597512
121Squamous cell carcinoma (HP:0002860)1.94488040
122EMG: myopathic abnormalities (HP:0003458)1.93765823
123Dysautonomia (HP:0002459)1.93764713
124Cellular immunodeficiency (HP:0005374)1.93640711
125Protruding tongue (HP:0010808)1.93327503
126Increased neuronal autofluorescent lipopigment (HP:0002074)1.93212286
127Upper limb muscle weakness (HP:0003484)1.92353723
128Emotional lability (HP:0000712)1.92087087
129Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.90942870
130Short 1st metacarpal (HP:0010034)1.90942870
131Proximal amyotrophy (HP:0007126)1.90564618
132Alveolar cell carcinoma (HP:0006519)1.89721931
133Conical tooth (HP:0000698)1.89194144
134Confusion (HP:0001289)1.87501674
135Abnormality of liposaccharide metabolism (HP:0010968)1.87348235
136Abnormality of glycosphingolipid metabolism (HP:0004343)1.87348235
137Abnormality of glycolipid metabolism (HP:0010969)1.87348235
138Sparse lateral eyebrow (HP:0005338)1.84399814
139Spontaneous abortion (HP:0005268)1.84350572
140Asplenia (HP:0001746)1.83852249
141Abnormal albumin level (HP:0012116)1.83771715
142Hypoalbuminemia (HP:0003073)1.83771715
143Anhidrosis (HP:0000970)1.82838714
144Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.82725508
145Abnormality of the ischium (HP:0003174)1.82241971
146Spontaneous hematomas (HP:0007420)1.81999736
147Neonatal hypoglycemia (HP:0001998)1.80798813
148Preauricular pit (HP:0004467)1.80691418
149Periauricular skin pits (HP:0100277)1.80691418
150Aplasia/Hypoplasia of the uvula (HP:0010293)1.79481627
151Difficulty climbing stairs (HP:0003551)1.79130668
152Wide intermamillary distance (HP:0006610)1.78845491
153Bone marrow hypocellularity (HP:0005528)1.78415000
154Abnormality of the columella (HP:0009929)1.77221177
155Down-sloping shoulders (HP:0200021)1.77068321
156Syncope (HP:0001279)1.75781167
157Clubbing of toes (HP:0100760)1.75331700
158Congenital, generalized hypertrichosis (HP:0004540)1.75220221
159Vertebral compression fractures (HP:0002953)1.73187290
160Abnormal respiratory motile cilium morphology (HP:0005938)1.73003596
161Abnormal respiratory epithelium morphology (HP:0012253)1.73003596
162Abnormality of the pons (HP:0007361)1.72787358
163Mesomelia (HP:0003027)1.72523651
164White forelock (HP:0002211)1.72500200
165Abnormality of the phalanges of the 2nd finger (HP:0009541)1.72251200
166Agnosia (HP:0010524)1.71350407
167Bone pain (HP:0002653)1.70535440
168Adactyly (HP:0009776)1.70173008
169Abnormal trabecular bone morphology (HP:0100671)1.70039956
170Mitochondrial inheritance (HP:0001427)1.69549786
171Constricted visual fields (HP:0001133)1.67977563
172Dysostosis multiplex (HP:0000943)1.67536056
173Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67355399
174Attenuation of retinal blood vessels (HP:0007843)1.66796706
175Distal lower limb muscle weakness (HP:0009053)1.66443477
176Paralysis (HP:0003470)1.65914719
177Aseptic necrosis (HP:0010885)1.65361089
178Small hand (HP:0200055)1.65284816
179Abnormality of the humerus (HP:0003063)1.64962412
180Furrowed tongue (HP:0000221)1.64587588
181Hyperkalemia (HP:0002153)1.64487146
182Abnormality of the 2nd finger (HP:0004100)1.64405969
183Anonychia (HP:0001798)1.64312410
184Abnormality of the 1st metacarpal (HP:0010009)1.63876004
185Tented upper lip vermilion (HP:0010804)1.62915373

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK129.77405953
2BRD46.18974840
3ZAK3.55137771
4TLK13.30271615
5MAP2K42.60333984
6TGFBR22.25033458
7IRAK32.21222011
8MKNK22.01374228
9BLK10.3064743
10GRK71.90683697
11TEC1.78276219
12TRIB31.75042651
13STK41.65919812
14INSRR1.63760145
15MAP2K71.61936266
16VRK11.57256382
17CDK91.54299523
18ITK1.54281568
19MAP3K61.48110864
20MARK31.45140887
21CDK81.40426382
22NEK91.30675832
23DAPK31.30009652
24SIK31.27825063
25SIK21.21365924
26PIM21.17860125
27PKN11.13529349
28MAP2K31.11050189
29TYK21.07610829
30STK101.06520200
31PIM11.05747445
32ADRBK21.05407597
33MKNK11.05374845
34CASK1.02849834
35EIF2AK21.01271940
36MAPK151.00596349
37MAP3K90.99546417
38CAMK1G0.98060140
39SGK20.96814282
40KDR0.95667719
41CAMK1D0.94819975
42YES10.94802177
43CDK70.94546401
44TTN0.93807263
45TAF10.89988550
46DYRK1A0.89407327
47AURKA0.87856132
48TXK0.82744949
49NME20.82593122
50BMPR20.82156976
51TAOK30.81940194
52EPHA20.79241179
53RPS6KA50.79050770
54SGK30.77634593
55HCK0.76398695
56ARAF0.75102109
57RPS6KC10.74716353
58RPS6KL10.74716353
59MAPK120.71706225
60TRPM70.70725659
61RET0.66532846
62CAMKK20.66035480
63CDK30.65648096
64RIPK10.65448656
65RPS6KA60.65091161
66NTRK30.64926141
67AKT30.64170501
68PRKAA10.61130042
69MAP3K40.60842175
70MAPK110.60798953
71JAK10.60462660
72MAP3K140.59929348
73ABL20.58177863
74RPS6KA20.57500806
75SMG10.55595294
76PHKG10.55154303
77PHKG20.55154303
78IRAK40.53816282
79MAPK70.53279397
80GRK10.52250428
81BTK0.51317968
82KIT0.51157275
83TNIK0.50817854
84TIE10.48609155
85EEF2K0.47994504
86EPHA30.47077976
87WNK10.46814461
88MAP3K20.46497240
89IKBKB0.46415715
90CDK60.45933307
91FLT30.43932700
92MAP3K80.43283494
93BRSK20.42387183
94SIK10.40773194
95PRKD20.40159743
96PDPK10.40029703
97PTK2B0.39555467
98FES0.39038871
99GRK50.38869324
100PDGFRB0.38765359
101MAPK40.38270797
102NLK0.36076436
103PIK3CG0.36060596
104MAPKAPK50.35884364
105LYN0.35410671
106PRKCQ0.35020838
107MAP3K70.34430298
108FGFR10.34398170
109ERBB30.34396490
110ICK0.33854585
111MAP2K20.32774132
112EIF2AK30.32340547
113ALK0.32260039
114HIPK20.31648721
115PRKAA20.31007175
116CAMK40.30084244
117RIPK40.29947022
118STK110.29933787
119PDK20.29192704
120MUSK0.28816389
121RPS6KB10.28813277
122PKN20.28345745
123TNK20.27996567
124SRPK10.27529590
125PRKG10.27190099
126MAPKAPK20.27128684
127PRPF4B0.26958676
128DYRK30.26764215
129MELK0.26412183
130OBSCN0.26409769
131MAP3K130.25942064
132MAPKAPK30.25682195
133ADRBK10.25549132
134SGK4940.25485937
135SGK2230.25485937
136STK160.25023095
137MAPK140.24224367
138AURKB0.23968944
139CSK0.23702841
140MOS0.23417417
141JAK20.23340214
142TAOK20.23029745
143ERBB40.22881128
144MAPK130.22662614
145PDK10.22431171
146STK30.21937149
147AKT20.21817841
148MARK20.21770283
149CAMK2B0.21621195
150MAP3K50.21541642
151CAMK2G0.20211161
152PRKDC0.19860734
153MAP3K30.19416940
154ROCK10.19387067
155ZAP700.19217987
156SYK0.18974740

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005344.83019080
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.16616092
3Systemic lupus erythematosus_Homo sapiens_hsa053223.14470041
4Folate biosynthesis_Homo sapiens_hsa007903.05059298
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.71607588
6Basal transcription factors_Homo sapiens_hsa030222.70541248
7Non-homologous end-joining_Homo sapiens_hsa034502.58921182
8Selenocompound metabolism_Homo sapiens_hsa004502.25157695
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.23217056
10Dilated cardiomyopathy_Homo sapiens_hsa054142.18395433
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.03766847
12Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.93045531
13Sphingolipid metabolism_Homo sapiens_hsa006001.92730395
14Sulfur metabolism_Homo sapiens_hsa009201.91925093
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.86944820
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.83724209
17Osteoclast differentiation_Homo sapiens_hsa043801.79538480
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.74954065
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.67283732
20Staphylococcus aureus infection_Homo sapiens_hsa051501.64938044
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.63683021
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62343502
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60230718
24Other glycan degradation_Homo sapiens_hsa005111.49276210
25Herpes simplex infection_Homo sapiens_hsa051681.46663487
26Alcoholism_Homo sapiens_hsa050341.38608338
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33343641
28Insulin secretion_Homo sapiens_hsa049111.30669496
29Sulfur relay system_Homo sapiens_hsa041221.29371849
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.29180839
31Apoptosis_Homo sapiens_hsa042101.27865725
32Mineral absorption_Homo sapiens_hsa049781.27575120
33GnRH signaling pathway_Homo sapiens_hsa049121.26772199
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21319602
35Fanconi anemia pathway_Homo sapiens_hsa034601.19892347
36Gap junction_Homo sapiens_hsa045401.18558423
37Rheumatoid arthritis_Homo sapiens_hsa053231.11654697
38Platelet activation_Homo sapiens_hsa046111.09701187
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07718136
40Longevity regulating pathway - mammal_Homo sapiens_hsa042111.07694479
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07490719
42Calcium signaling pathway_Homo sapiens_hsa040201.07488306
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06841804
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05144257
45Basal cell carcinoma_Homo sapiens_hsa052171.04832413
46Leishmaniasis_Homo sapiens_hsa051401.04074994
47Type II diabetes mellitus_Homo sapiens_hsa049301.03887664
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03802452
49TNF signaling pathway_Homo sapiens_hsa046681.01828279
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99825094
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99318639
52Hepatitis B_Homo sapiens_hsa051610.98800893
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97990708
54Cholinergic synapse_Homo sapiens_hsa047250.97643332
55Nicotine addiction_Homo sapiens_hsa050330.95993216
56Pertussis_Homo sapiens_hsa051330.94705724
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.94295392
58Insulin resistance_Homo sapiens_hsa049310.93085558
59Melanogenesis_Homo sapiens_hsa049160.90497310
60Vitamin digestion and absorption_Homo sapiens_hsa049770.88475382
61Hedgehog signaling pathway_Homo sapiens_hsa043400.87067085
62Thyroid hormone synthesis_Homo sapiens_hsa049180.86058278
63Hematopoietic cell lineage_Homo sapiens_hsa046400.85629256
64Lysosome_Homo sapiens_hsa041420.85294429
65Axon guidance_Homo sapiens_hsa043600.84770249
66Tuberculosis_Homo sapiens_hsa051520.84393178
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84367994
68Bile secretion_Homo sapiens_hsa049760.80568661
69p53 signaling pathway_Homo sapiens_hsa041150.80301537
70Measles_Homo sapiens_hsa051620.78868633
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.78517793
72African trypanosomiasis_Homo sapiens_hsa051430.77127615
73Toxoplasmosis_Homo sapiens_hsa051450.77033194
74Colorectal cancer_Homo sapiens_hsa052100.77007605
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74467495
76B cell receptor signaling pathway_Homo sapiens_hsa046620.74061566
77Viral carcinogenesis_Homo sapiens_hsa052030.73203751
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72259112
79Pancreatic cancer_Homo sapiens_hsa052120.72183677
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71721877
81Glutamatergic synapse_Homo sapiens_hsa047240.70810906
82Chronic myeloid leukemia_Homo sapiens_hsa052200.70218272
83Malaria_Homo sapiens_hsa051440.69746182
84mTOR signaling pathway_Homo sapiens_hsa041500.69362243
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.67695114
86Oxytocin signaling pathway_Homo sapiens_hsa049210.67232180
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.67062956
88MAPK signaling pathway_Homo sapiens_hsa040100.66820622
89Phagosome_Homo sapiens_hsa041450.65145643
90Estrogen signaling pathway_Homo sapiens_hsa049150.64986713
91Melanoma_Homo sapiens_hsa052180.63985049
92MicroRNAs in cancer_Homo sapiens_hsa052060.63391569
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62608548
94Renin-angiotensin system_Homo sapiens_hsa046140.62230472
95FoxO signaling pathway_Homo sapiens_hsa040680.61423566
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60678926
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60529708
98T cell receptor signaling pathway_Homo sapiens_hsa046600.59606828
99Lysine degradation_Homo sapiens_hsa003100.58094598
100Prolactin signaling pathway_Homo sapiens_hsa049170.56597824
101ABC transporters_Homo sapiens_hsa020100.56124490
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55696628
103Influenza A_Homo sapiens_hsa051640.55227014
104Circadian entrainment_Homo sapiens_hsa047130.54859245
105Notch signaling pathway_Homo sapiens_hsa043300.54636241
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54190010
107Graft-versus-host disease_Homo sapiens_hsa053320.54081937
108Salivary secretion_Homo sapiens_hsa049700.53540684
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53456855
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52524400
111Taste transduction_Homo sapiens_hsa047420.52422643
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52327677
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.52128084
114Rap1 signaling pathway_Homo sapiens_hsa040150.52102894
115Bladder cancer_Homo sapiens_hsa052190.52028583
116TGF-beta signaling pathway_Homo sapiens_hsa043500.51056416
117Renin secretion_Homo sapiens_hsa049240.50544934
118PPAR signaling pathway_Homo sapiens_hsa033200.48686444
119Chemokine signaling pathway_Homo sapiens_hsa040620.47717882
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47481512
121Homologous recombination_Homo sapiens_hsa034400.47286937
122Arachidonic acid metabolism_Homo sapiens_hsa005900.46610243
123GABAergic synapse_Homo sapiens_hsa047270.45599332
124cAMP signaling pathway_Homo sapiens_hsa040240.45477080
125Ether lipid metabolism_Homo sapiens_hsa005650.45345361
126Primary immunodeficiency_Homo sapiens_hsa053400.44601579
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44463626
128Pathways in cancer_Homo sapiens_hsa052000.43190442
129N-Glycan biosynthesis_Homo sapiens_hsa005100.42189299
130Small cell lung cancer_Homo sapiens_hsa052220.41837152
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41821340
132Non-small cell lung cancer_Homo sapiens_hsa052230.41248684
133Gastric acid secretion_Homo sapiens_hsa049710.39320952
134ErbB signaling pathway_Homo sapiens_hsa040120.38910488
135Complement and coagulation cascades_Homo sapiens_hsa046100.38818239
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.38621353
137Circadian rhythm_Homo sapiens_hsa047100.38428447
138Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38301214
139Wnt signaling pathway_Homo sapiens_hsa043100.37064888
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36861128
141Dorso-ventral axis formation_Homo sapiens_hsa043200.36461224
142Retinol metabolism_Homo sapiens_hsa008300.35402984
143Allograft rejection_Homo sapiens_hsa053300.34741007
144HTLV-I infection_Homo sapiens_hsa051660.34695868
145Phototransduction_Homo sapiens_hsa047440.34319591
146Morphine addiction_Homo sapiens_hsa050320.33854343
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33243071
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33193783
149Glioma_Homo sapiens_hsa052140.33097149
150Ovarian steroidogenesis_Homo sapiens_hsa049130.33008149
151Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32873804
152Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31452251
153Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30766825
154Steroid hormone biosynthesis_Homo sapiens_hsa001400.30579269
155Chemical carcinogenesis_Homo sapiens_hsa052040.29946707
156Neurotrophin signaling pathway_Homo sapiens_hsa047220.29815154
157Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29801276
158Pancreatic secretion_Homo sapiens_hsa049720.28194941
159Choline metabolism in cancer_Homo sapiens_hsa052310.28137066
160Oocyte meiosis_Homo sapiens_hsa041140.24446629

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