HERC2P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.40834337
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78865132
3L-fucose catabolic process (GO:0042355)3.57330214
4fucose catabolic process (GO:0019317)3.57330214
5L-fucose metabolic process (GO:0042354)3.57330214
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.50511512
7negative regulation of cytosolic calcium ion concentration (GO:0051481)3.43122022
8detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.34187649
9auditory behavior (GO:0031223)3.31950855
10negative regulation of translation, ncRNA-mediated (GO:0040033)3.27347193
11regulation of translation, ncRNA-mediated (GO:0045974)3.27347193
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.27347193
13cilium or flagellum-dependent cell motility (GO:0001539)3.27097710
14behavioral response to ethanol (GO:0048149)3.24172310
15piRNA metabolic process (GO:0034587)3.09447578
16interkinetic nuclear migration (GO:0022027)3.06957288
17presynaptic membrane assembly (GO:0097105)3.05576928
18membrane depolarization during action potential (GO:0086010)3.03174731
19response to pheromone (GO:0019236)3.02720367
20neuronal action potential (GO:0019228)3.00295869
21dendritic spine morphogenesis (GO:0060997)2.96237561
22DNA methylation involved in gamete generation (GO:0043046)2.95722276
23mechanosensory behavior (GO:0007638)2.93604943
24neuronal action potential propagation (GO:0019227)2.93412866
25inner ear receptor stereocilium organization (GO:0060122)2.92039817
26gamma-aminobutyric acid transport (GO:0015812)2.90304575
27sulfation (GO:0051923)2.88852678
28cAMP catabolic process (GO:0006198)2.86158331
29vocalization behavior (GO:0071625)2.85367268
30presynaptic membrane organization (GO:0097090)2.84672483
31axon ensheathment in central nervous system (GO:0032291)2.78789350
32central nervous system myelination (GO:0022010)2.78789350
33regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78163477
34protein localization to cilium (GO:0061512)2.78138772
35auditory receptor cell stereocilium organization (GO:0060088)2.77231483
36nephron tubule morphogenesis (GO:0072078)2.77219725
37nephron epithelium morphogenesis (GO:0072088)2.77219725
38detection of light stimulus involved in sensory perception (GO:0050962)2.76831436
39detection of light stimulus involved in visual perception (GO:0050908)2.76831436
40cyclic nucleotide catabolic process (GO:0009214)2.74715492
41negative regulation of synaptic transmission, GABAergic (GO:0032229)2.72867132
42positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.68394126
43pyrimidine nucleobase catabolic process (GO:0006208)2.67407931
44synaptic vesicle maturation (GO:0016188)2.66880850
45somite development (GO:0061053)2.66593580
46histone H3-K4 trimethylation (GO:0080182)2.66140066
47indolalkylamine metabolic process (GO:0006586)2.66079291
48indole-containing compound catabolic process (GO:0042436)2.59462232
49indolalkylamine catabolic process (GO:0046218)2.59462232
50tryptophan catabolic process (GO:0006569)2.59462232
51postsynaptic membrane organization (GO:0001941)2.58902015
52regulation of pigment cell differentiation (GO:0050932)2.57736702
53protein import into peroxisome matrix (GO:0016558)2.56924310
54retinal cone cell development (GO:0046549)2.55780257
55monoubiquitinated protein deubiquitination (GO:0035520)2.55647076
56photoreceptor cell maintenance (GO:0045494)2.55283048
57regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.54853036
58ionotropic glutamate receptor signaling pathway (GO:0035235)2.52873180
59negative regulation of transcription regulatory region DNA binding (GO:2000678)2.52637812
60nonmotile primary cilium assembly (GO:0035058)2.50336818
61glutamate receptor signaling pathway (GO:0007215)2.49561332
62rRNA catabolic process (GO:0016075)2.48145734
63renal tubule morphogenesis (GO:0061333)2.47707707
64epithelial cilium movement (GO:0003351)2.47508398
65action potential (GO:0001508)2.47005033
66positive regulation of developmental pigmentation (GO:0048087)2.46754462
67cilium organization (GO:0044782)2.46664403
68neurotransmitter catabolic process (GO:0042135)2.46642820
69negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.46192407
70negative regulation of neurotransmitter transport (GO:0051589)2.45627853
71detection of mechanical stimulus involved in sensory perception (GO:0050974)2.44582306
72kynurenine metabolic process (GO:0070189)2.44418806
73cilium morphogenesis (GO:0060271)2.43564410
74neural tube formation (GO:0001841)2.43324653
75serotonin metabolic process (GO:0042428)2.41359848
76atrial cardiac muscle cell action potential (GO:0086014)2.40897195
77cilium assembly (GO:0042384)2.40750375
78transmission of nerve impulse (GO:0019226)2.39975497
79neuron cell-cell adhesion (GO:0007158)2.38858514
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.38793710
81synaptic transmission, glutamatergic (GO:0035249)2.38347599
82startle response (GO:0001964)2.37416193
83reflex (GO:0060004)2.34249594
84G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.34224065
85spinal cord development (GO:0021510)2.34012291
86positive regulation of CREB transcription factor activity (GO:0032793)2.33917881
87positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.33390656
88intraciliary transport (GO:0042073)2.33354058
89spinal cord motor neuron differentiation (GO:0021522)2.31962170
90hindbrain development (GO:0030902)2.31526148
91cellular ketone body metabolic process (GO:0046950)2.31263331
92C4-dicarboxylate transport (GO:0015740)2.31112602
93neurotransmitter-gated ion channel clustering (GO:0072578)2.30347005
94primary amino compound metabolic process (GO:1901160)2.29740728
95proline transport (GO:0015824)2.29716616
96indole-containing compound metabolic process (GO:0042430)2.29435432
97establishment of protein localization to Golgi (GO:0072600)2.28876313
98protein localization to synapse (GO:0035418)2.28195181
99ketone body metabolic process (GO:1902224)2.26969793
100negative regulation of smooth muscle cell differentiation (GO:0051151)2.26123995

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.51352234
2EZH2_22144423_ChIP-Seq_EOC_Human3.36879838
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.34766524
4VDR_22108803_ChIP-Seq_LS180_Human3.00291769
5ZNF274_21170338_ChIP-Seq_K562_Hela2.92316539
6IGF1R_20145208_ChIP-Seq_DFB_Human2.74923191
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70449503
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.66143658
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.58941259
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.41026703
11TAF15_26573619_Chip-Seq_HEK293_Human2.36962697
12FUS_26573619_Chip-Seq_HEK293_Human2.21694847
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.16833765
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.15348365
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14057873
16EWS_26573619_Chip-Seq_HEK293_Human2.01289413
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.97636898
18P300_19829295_ChIP-Seq_ESCs_Human1.93833147
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92559926
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80125825
21SMAD4_21799915_ChIP-Seq_A2780_Human1.79366063
22ER_23166858_ChIP-Seq_MCF-7_Human1.78924050
23STAT3_23295773_ChIP-Seq_U87_Human1.78411458
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.72674640
25REST_21632747_ChIP-Seq_MESCs_Mouse1.70092772
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.69974977
27TCF4_23295773_ChIP-Seq_U87_Human1.65111800
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62024659
29RNF2_27304074_Chip-Seq_NSC_Mouse1.59861675
30AR_21572438_ChIP-Seq_LNCaP_Human1.57163237
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.56318345
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54851276
33AR_25329375_ChIP-Seq_VCAP_Human1.54618471
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51120525
35CBP_20019798_ChIP-Seq_JUKART_Human1.51120525
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50533585
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49530099
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49530099
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48619844
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46885798
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45857590
42BCAT_22108803_ChIP-Seq_LS180_Human1.45509105
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.43595376
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43533949
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42975984
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40057825
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.38529284
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38267635
49TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.38142704
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36874105
51DROSHA_22980978_ChIP-Seq_HELA_Human1.35757238
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35426205
53RUNX2_22187159_ChIP-Seq_PCA_Human1.32839160
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30208852
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24972330
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24901100
57PRDM14_20953172_ChIP-Seq_ESCs_Human1.24672720
58TCF4_22108803_ChIP-Seq_LS180_Human1.24216323
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22620695
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22318651
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.21423887
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21233886
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.20971262
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18701904
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17974422
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17675117
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.17336275
68IRF1_19129219_ChIP-ChIP_H3396_Human1.16049680
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15663573
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15266853
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13897777
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13640379
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13366938
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12927257
75TP53_22573176_ChIP-Seq_HFKS_Human1.11923760
76TP53_16413492_ChIP-PET_HCT116_Human1.11475114
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.11451509
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11191758
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11147693
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.10937278
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.09260937
82P53_22387025_ChIP-Seq_ESCs_Mouse1.08240811
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07951398
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07237559
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06604607
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06275491
87RXR_22108803_ChIP-Seq_LS180_Human1.05512705
88JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04822247
89EZH2_27294783_Chip-Seq_ESCs_Mouse1.04588484
90RNF2_27304074_Chip-Seq_ESCs_Mouse1.03123507
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.02040649
92KDM2B_26808549_Chip-Seq_REH_Human1.01954062
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01049287
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00966917
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00629113
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.00196606
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99355343
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.99048326
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97506916
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97203801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.08864615
2MP0004147_increased_porphyrin_level2.50802539
3MP0005646_abnormal_pituitary_gland2.44856971
4MP0004885_abnormal_endolymph2.42003213
5MP0000569_abnormal_digit_pigmentation2.34473787
6MP0009745_abnormal_behavioral_response2.33925095
7MP0003787_abnormal_imprinting2.24789160
8MP0001486_abnormal_startle_reflex2.23855541
9MP0005551_abnormal_eye_electrophysiolog2.15889793
10MP0008877_abnormal_DNA_methylation2.15669681
11MP0009046_muscle_twitch2.12826427
12MP0002102_abnormal_ear_morphology2.10902560
13MP0002272_abnormal_nervous_system2.06576343
14MP0001986_abnormal_taste_sensitivity2.05625367
15MP0001968_abnormal_touch/_nociception2.02116265
16MP0004859_abnormal_synaptic_plasticity2.01946675
17MP0003635_abnormal_synaptic_transmissio1.99512860
18MP0004145_abnormal_muscle_electrophysio1.97703306
19MP0002638_abnormal_pupillary_reflex1.97055835
20MP0002064_seizures1.96158811
21MP0001501_abnormal_sleep_pattern1.95684324
22MP0006276_abnormal_autonomic_nervous1.91896229
23MP0003195_calcinosis1.90199842
24MP0004043_abnormal_pH_regulation1.89214199
25MP0002572_abnormal_emotion/affect_behav1.88391860
26MP0002735_abnormal_chemical_nociception1.74922652
27MP0005423_abnormal_somatic_nervous1.74848388
28MP0002063_abnormal_learning/memory/cond1.73689744
29MP0000631_abnormal_neuroendocrine_gland1.69580497
30MP0006072_abnormal_retinal_apoptosis1.66242189
31MP0006292_abnormal_olfactory_placode1.62258740
32MP0000778_abnormal_nervous_system1.61261269
33MP0004133_heterotaxia1.55624999
34MP0001970_abnormal_pain_threshold1.52571142
35MP0008775_abnormal_heart_ventricle1.50381957
36MP0005187_abnormal_penis_morphology1.47583016
37MP0002557_abnormal_social/conspecific_i1.47550444
38MP0005253_abnormal_eye_physiology1.46617144
39MP0005386_behavior/neurological_phenoty1.45770682
40MP0004924_abnormal_behavior1.45770682
41MP0000372_irregular_coat_pigmentation1.44085017
42MP0004215_abnormal_myocardial_fiber1.42592993
43MP0002734_abnormal_mechanical_nocicepti1.42558093
44MP0001984_abnormal_olfaction1.42208785
45MP0001485_abnormal_pinna_reflex1.41334120
46MP0002736_abnormal_nociception_after1.41296747
47MP0008995_early_reproductive_senescence1.39921924
48MP0000427_abnormal_hair_cycle1.34507826
49MP0000383_abnormal_hair_follicle1.32663473
50MP0002733_abnormal_thermal_nociception1.32218318
51MP0005167_abnormal_blood-brain_barrier1.31996021
52MP0004270_analgesia1.31026973
53MP0002009_preneoplasia1.29048424
54MP0001502_abnormal_circadian_rhythm1.27885395
55MP0001440_abnormal_grooming_behavior1.26000795
56MP0002067_abnormal_sensory_capabilities1.25168327
57MP0002822_catalepsy1.22701382
58MP0002837_dystrophic_cardiac_calcinosis1.18266491
59MP0002928_abnormal_bile_duct1.17729843
60MP0003121_genomic_imprinting1.16330778
61MP0010386_abnormal_urinary_bladder1.15882812
62MP0002938_white_spotting1.13481012
63MP0005645_abnormal_hypothalamus_physiol1.13325051
64MP0004142_abnormal_muscle_tone1.12065967
65MP0003646_muscle_fatigue1.10195243
66MP0003137_abnormal_impulse_conducting1.09380078
67MP0004085_abnormal_heartbeat1.09160297
68MP0003136_yellow_coat_color1.08978293
69MP0008872_abnormal_physiological_respon1.06543577
70MP0002138_abnormal_hepatobiliary_system1.05999963
71MP0004742_abnormal_vestibular_system1.03362292
72MP0002882_abnormal_neuron_morphology1.02794213
73MP0002184_abnormal_innervation1.00488461
74MP0001188_hyperpigmentation0.99029725
75MP0002229_neurodegeneration0.98362794
76MP0002876_abnormal_thyroid_physiology0.95034217
77MP0003890_abnormal_embryonic-extraembry0.94951381
78MP0000955_abnormal_spinal_cord0.94783687
79MP0004130_abnormal_muscle_cell0.93495751
80MP0002752_abnormal_somatic_nervous0.93473814
81MP0005171_absent_coat_pigmentation0.92953611
82MP0000230_abnormal_systemic_arterial0.92214533
83MP0005174_abnormal_tail_pigmentation0.91425699
84MP0004484_altered_response_of0.88850268
85MP0000516_abnormal_urinary_system0.86702022
86MP0005367_renal/urinary_system_phenotyp0.86702022
87MP0010368_abnormal_lymphatic_system0.86388874
88MP0001963_abnormal_hearing_physiology0.86226647
89MP0003698_abnormal_male_reproductive0.84869393
90MP0003633_abnormal_nervous_system0.84225892
91MP0000026_abnormal_inner_ear0.83486693
92MP0001879_abnormal_lymphatic_vessel0.82421214
93MP0003283_abnormal_digestive_organ0.81783912
94MP0002234_abnormal_pharynx_morphology0.81133172
95MP0002066_abnormal_motor_capabilities/c0.77366078
96MP0002152_abnormal_brain_morphology0.77257893
97MP0005195_abnormal_posterior_eye0.76419618
98MP0000538_abnormal_urinary_bladder0.75731674
99MP0003119_abnormal_digestive_system0.72981223
100MP0004084_abnormal_cardiac_muscle0.72377031

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)3.94104545
2Nephronophthisis (HP:0000090)3.89033765
3Pancreatic cysts (HP:0001737)3.68045332
4Abnormality of the renal medulla (HP:0100957)3.50418744
5Febrile seizures (HP:0002373)3.45864399
6Pancreatic fibrosis (HP:0100732)3.39939075
7Genetic anticipation (HP:0003743)3.32661835
8True hermaphroditism (HP:0010459)3.23626469
9Molar tooth sign on MRI (HP:0002419)3.20567123
10Abnormality of midbrain morphology (HP:0002418)3.20567123
11Medial flaring of the eyebrow (HP:0010747)3.19413574
12Progressive cerebellar ataxia (HP:0002073)3.17314756
13Hemiparesis (HP:0001269)3.12372700
14Focal seizures (HP:0007359)3.10899070
15Broad-based gait (HP:0002136)3.10363988
16Abnormality of the renal cortex (HP:0011035)3.06974838
17Type II lissencephaly (HP:0007260)3.05113825
18Focal motor seizures (HP:0011153)3.03137531
19Gaze-evoked nystagmus (HP:0000640)3.00136258
20Congenital stationary night blindness (HP:0007642)2.94153206
21Atonic seizures (HP:0010819)2.89697660
22Abnormal drinking behavior (HP:0030082)2.83689790
23Polydipsia (HP:0001959)2.83689790
24Protruding tongue (HP:0010808)2.83448775
25Gait imbalance (HP:0002141)2.74453037
26Cerebellar dysplasia (HP:0007033)2.68384189
27Cystic liver disease (HP:0006706)2.65369382
28Drooling (HP:0002307)2.64783937
29Dialeptic seizures (HP:0011146)2.57407265
30Decreased circulating renin level (HP:0003351)2.57184992
31Congenital primary aphakia (HP:0007707)2.47358612
32Attenuation of retinal blood vessels (HP:0007843)2.44487205
33Widely spaced teeth (HP:0000687)2.42152903
34Tubular atrophy (HP:0000092)2.40989756
35Hypothermia (HP:0002045)2.40191544
36Congenital hepatic fibrosis (HP:0002612)2.38639057
37Abolished electroretinogram (ERG) (HP:0000550)2.35259664
38Large for gestational age (HP:0001520)2.34718507
39Chronic hepatic failure (HP:0100626)2.34101711
40Excessive salivation (HP:0003781)2.33648276
41Clumsiness (HP:0002312)2.26274088
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.22105174
43Nephrogenic diabetes insipidus (HP:0009806)2.21983690
44Increased corneal curvature (HP:0100692)2.21398996
45Keratoconus (HP:0000563)2.21398996
46Epileptic encephalopathy (HP:0200134)2.19140311
47Dyskinesia (HP:0100660)2.17566959
48Absence seizures (HP:0002121)2.13542845
49Genital tract atresia (HP:0001827)2.11774393
50Abnormality of binocular vision (HP:0011514)2.11310629
51Diplopia (HP:0000651)2.11310629
52Absent speech (HP:0001344)2.08269747
53Vaginal atresia (HP:0000148)2.07727781
54Polyuria (HP:0000103)2.06607881
55Prolonged QT interval (HP:0001657)2.04620982
56Decreased central vision (HP:0007663)2.03456106
57Poor coordination (HP:0002370)2.03076988
58Abnormality of the renal collecting system (HP:0004742)2.00220991
59Inability to walk (HP:0002540)1.98934566
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96491026
61Degeneration of the lateral corticospinal tracts (HP:0002314)1.96491026
62Hypoplastic iliac wings (HP:0002866)1.95923500
63Stomach cancer (HP:0012126)1.95307990
64Duplicated collecting system (HP:0000081)1.93555380
65Abnormality of the ischium (HP:0003174)1.92854323
66Renal cortical cysts (HP:0000803)1.91625307
67Volvulus (HP:0002580)1.91192437
68Tubulointerstitial nephritis (HP:0001970)1.91102076
69Concave nail (HP:0001598)1.89913701
70Anterior segment dysgenesis (HP:0007700)1.89325982
71Pachygyria (HP:0001302)1.88834939
72Lissencephaly (HP:0001339)1.86337979
73Bile duct proliferation (HP:0001408)1.86079805
74Abnormal biliary tract physiology (HP:0012439)1.86079805
75Absent/shortened dynein arms (HP:0200106)1.85802443
76Dynein arm defect of respiratory motile cilia (HP:0012255)1.85802443
77Fair hair (HP:0002286)1.83679621
78Short foot (HP:0001773)1.82283021
79Tachypnea (HP:0002789)1.80290422
80Hypoplastic ischia (HP:0003175)1.79343364
81Specific learning disability (HP:0001328)1.76128650
82Generalized tonic-clonic seizures (HP:0002069)1.75386169
83Neoplasm of the adrenal cortex (HP:0100641)1.74570005
84Chorioretinal atrophy (HP:0000533)1.74154397
85Progressive inability to walk (HP:0002505)1.74096171
86Blue irides (HP:0000635)1.73985765
87Patellar aplasia (HP:0006443)1.73492428
88Polyphagia (HP:0002591)1.73110284
89Urinary bladder sphincter dysfunction (HP:0002839)1.72420236
90Aqueductal stenosis (HP:0002410)1.68900749
91Abnormality of renin-angiotensin system (HP:0000847)1.68262222
92Abnormal respiratory motile cilium morphology (HP:0005938)1.66341111
93Abnormal respiratory epithelium morphology (HP:0012253)1.66341111
94Highly arched eyebrow (HP:0002553)1.65323266
95Small hand (HP:0200055)1.64249524
96Dysdiadochokinesis (HP:0002075)1.63387697
97Postaxial foot polydactyly (HP:0001830)1.63068410
98Thyroid-stimulating hormone excess (HP:0002925)1.63021106
99Postaxial hand polydactyly (HP:0001162)1.62668641
100Furrowed tongue (HP:0000221)1.61891853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.99730760
2MAP4K22.81239911
3PINK12.56413890
4ACVR1B2.53060929
5BMPR1B2.35747263
6CASK2.20482290
7MAPK132.19795359
8MARK12.16598993
9NTRK32.16288555
10FGFR22.05139640
11PNCK2.00635573
12MAP3K41.96013054
13WNK31.86913248
14WNK41.82748229
15ADRBK21.69190875
16OXSR11.68644719
17STK391.58169605
18NUAK11.55499126
19MKNK21.54519665
20GRK11.53522398
21EPHA41.53475127
22TNIK1.45568544
23TAOK31.45352287
24DAPK21.43784262
25AKT31.42978418
26TIE11.36433050
27MAPK151.31651960
28INSRR1.25436982
29PIK3CA1.24828868
30PHKG11.24263073
31PHKG21.24263073
32TEC1.22379961
33NTRK21.21643395
34CAMK1G1.19098378
35TLK11.12503452
36CAMK1D1.09988496
37PAK31.06688305
38CAMKK21.05254176
39PRKD31.03999273
40MKNK11.03576643
41MAPKAPK31.03021862
42ERBB30.91821811
43PLK20.90740400
44CDK30.83905574
45SGK20.83411031
46MINK10.82934670
47WNK10.80736350
48PRKCE0.80721757
49MAP2K60.80481536
50EPHA30.77671284
51ZAK0.77629673
52CAMK10.77100637
53TRPM70.76633042
54MAPKAPK50.76342414
55STK110.76213649
56TGFBR10.75000448
57BRD40.74888604
58EPHB20.73551920
59ITK0.73428498
60PTK2B0.70216731
61OBSCN0.70152598
62MAP2K40.69972066
63KIT0.67401422
64SIK20.64496651
65DYRK1A0.62863026
66PRKCG0.61574250
67ADRBK10.61414588
68NLK0.59474694
69CAMK2A0.59025500
70DYRK20.58994951
71MAP3K70.58471608
72PRKAA20.58268925
73SGK4940.57666283
74SGK2230.57666283
75SGK10.56650192
76BRSK20.56624951
77WEE10.55920748
78PRKAA10.50288136
79TYRO30.48864608
80CAMKK10.47781316
81PRKG10.47295155
82ERBB20.47221883
83IRAK10.46493977
84UHMK10.45557981
85CSNK1G20.45312446
86FLT30.45282623
87MAP2K70.44744383
88PRKCH0.44527631
89TRIM280.44421332
90CDK50.41389228
91FER0.41071782
92PRKACA0.40574256
93CAMK40.39904544
94RPS6KA30.37805255
95STK38L0.37028231
96CSNK1G10.36020248
97CSNK1A1L0.35906295
98PAK60.35759003
99RPS6KA50.35549084
100PKN10.34688221

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.26223947
2Phototransduction_Homo sapiens_hsa047442.75127096
3Circadian entrainment_Homo sapiens_hsa047132.27551415
4Morphine addiction_Homo sapiens_hsa050322.16858124
5Glutamatergic synapse_Homo sapiens_hsa047242.15077681
6Insulin secretion_Homo sapiens_hsa049112.14234199
7Taste transduction_Homo sapiens_hsa047422.12492484
8Butanoate metabolism_Homo sapiens_hsa006502.08927510
9Nitrogen metabolism_Homo sapiens_hsa009102.07907255
10Linoleic acid metabolism_Homo sapiens_hsa005912.06792431
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.03735389
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.01336702
13GABAergic synapse_Homo sapiens_hsa047271.99117648
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88837961
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78080236
16Salivary secretion_Homo sapiens_hsa049701.71953539
17ABC transporters_Homo sapiens_hsa020101.71378206
18Amphetamine addiction_Homo sapiens_hsa050311.65194874
19Regulation of autophagy_Homo sapiens_hsa041401.62049936
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59792903
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58950384
22Ether lipid metabolism_Homo sapiens_hsa005651.58605509
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.55486085
24Olfactory transduction_Homo sapiens_hsa047401.53840153
25Serotonergic synapse_Homo sapiens_hsa047261.51943639
26Dopaminergic synapse_Homo sapiens_hsa047281.49085984
27Cocaine addiction_Homo sapiens_hsa050301.48442270
28Calcium signaling pathway_Homo sapiens_hsa040201.47512251
29Renin secretion_Homo sapiens_hsa049241.47390971
30Tryptophan metabolism_Homo sapiens_hsa003801.42496311
31Dorso-ventral axis formation_Homo sapiens_hsa043201.41126381
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38736164
33Propanoate metabolism_Homo sapiens_hsa006401.37909160
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34726907
35Ovarian steroidogenesis_Homo sapiens_hsa049131.31476382
36Cholinergic synapse_Homo sapiens_hsa047251.31396754
37Oxytocin signaling pathway_Homo sapiens_hsa049211.29953238
38Long-term depression_Homo sapiens_hsa047301.28904753
39Gastric acid secretion_Homo sapiens_hsa049711.27989332
40Fanconi anemia pathway_Homo sapiens_hsa034601.25271041
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.20519749
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14544008
43cAMP signaling pathway_Homo sapiens_hsa040241.10750958
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09952825
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09863748
46Circadian rhythm_Homo sapiens_hsa047101.03244581
47Lysine degradation_Homo sapiens_hsa003100.98116617
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95594554
49Selenocompound metabolism_Homo sapiens_hsa004500.94523278
50Caffeine metabolism_Homo sapiens_hsa002320.92682476
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87882676
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87550421
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87180433
54Basal transcription factors_Homo sapiens_hsa030220.85047936
55Cardiac muscle contraction_Homo sapiens_hsa042600.82141909
56Bile secretion_Homo sapiens_hsa049760.82117229
57Homologous recombination_Homo sapiens_hsa034400.79016653
58Pancreatic secretion_Homo sapiens_hsa049720.75501937
59Peroxisome_Homo sapiens_hsa041460.75286845
60Glycerolipid metabolism_Homo sapiens_hsa005610.72226392
61Long-term potentiation_Homo sapiens_hsa047200.66056548
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64916770
63Thyroid hormone synthesis_Homo sapiens_hsa049180.63130191
64RNA degradation_Homo sapiens_hsa030180.62606405
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.61705657
66Type II diabetes mellitus_Homo sapiens_hsa049300.60076220
67Histidine metabolism_Homo sapiens_hsa003400.59369164
68Glucagon signaling pathway_Homo sapiens_hsa049220.59334976
69Arachidonic acid metabolism_Homo sapiens_hsa005900.59178797
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.59161403
71Axon guidance_Homo sapiens_hsa043600.58925992
72Synaptic vesicle cycle_Homo sapiens_hsa047210.57956004
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.56476106
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56434124
75beta-Alanine metabolism_Homo sapiens_hsa004100.55924653
76Estrogen signaling pathway_Homo sapiens_hsa049150.54350252
77Choline metabolism in cancer_Homo sapiens_hsa052310.53377232
78GnRH signaling pathway_Homo sapiens_hsa049120.52574430
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.51513434
80Asthma_Homo sapiens_hsa053100.51211526
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51198402
82Dilated cardiomyopathy_Homo sapiens_hsa054140.51015428
83Chemical carcinogenesis_Homo sapiens_hsa052040.49455503
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46965556
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.46934004
86Oocyte meiosis_Homo sapiens_hsa041140.46771021
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46291156
88MAPK signaling pathway_Homo sapiens_hsa040100.45832981
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43088286
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42986658
91Protein export_Homo sapiens_hsa030600.42267191
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41930352
93Ras signaling pathway_Homo sapiens_hsa040140.41880290
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41701235
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40384391
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40018197
97Melanogenesis_Homo sapiens_hsa049160.39240478
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38341995
99Platelet activation_Homo sapiens_hsa046110.37383533
100Retinol metabolism_Homo sapiens_hsa008300.37122414

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