HERC2P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.83889702
2response to pheromone (GO:0019236)4.17999675
3kynurenine metabolic process (GO:0070189)4.13076621
4fucose catabolic process (GO:0019317)4.08822259
5L-fucose metabolic process (GO:0042354)4.08822259
6L-fucose catabolic process (GO:0042355)4.08822259
7tryptophan catabolic process (GO:0006569)4.00843685
8indole-containing compound catabolic process (GO:0042436)4.00843685
9indolalkylamine catabolic process (GO:0046218)4.00843685
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.79455673
11indolalkylamine metabolic process (GO:0006586)3.69045210
12neuronal action potential (GO:0019228)3.63609423
13tryptophan metabolic process (GO:0006568)3.58380480
14cellular ketone body metabolic process (GO:0046950)3.52273660
15detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.45282225
16gamma-aminobutyric acid transport (GO:0015812)3.35665047
17primary amino compound metabolic process (GO:1901160)3.30382837
18indole-containing compound metabolic process (GO:0042430)3.29210686
19serotonin metabolic process (GO:0042428)3.24798049
20behavioral response to ethanol (GO:0048149)3.24240272
21sulfation (GO:0051923)3.23444638
22neural tube formation (GO:0001841)3.21160834
23synaptic transmission, cholinergic (GO:0007271)3.19422029
24ketone body metabolic process (GO:1902224)3.17745354
25regulation of action potential (GO:0098900)3.12198533
26epithelial cilium movement (GO:0003351)3.11799188
27nephron tubule morphogenesis (GO:0072078)3.09050891
28nephron epithelium morphogenesis (GO:0072088)3.09050891
29nonmotile primary cilium assembly (GO:0035058)3.01356895
30regulation of nuclear cell cycle DNA replication (GO:0033262)2.96516301
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.94988144
32rRNA catabolic process (GO:0016075)2.94093722
33negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93056734
34pyrimidine nucleobase catabolic process (GO:0006208)2.91257496
35cilium or flagellum-dependent cell motility (GO:0001539)2.90786880
36detection of light stimulus involved in sensory perception (GO:0050962)2.87678915
37detection of light stimulus involved in visual perception (GO:0050908)2.87678915
38negative regulation of telomere maintenance (GO:0032205)2.86086485
39reflex (GO:0060004)2.85890659
40negative regulation of mast cell activation (GO:0033004)2.84290693
41water-soluble vitamin biosynthetic process (GO:0042364)2.80743232
42spinal cord motor neuron differentiation (GO:0021522)2.78433655
43positive regulation of action potential (GO:0045760)2.76468416
44mitochondrial respiratory chain complex I assembly (GO:0032981)2.74402995
45NADH dehydrogenase complex assembly (GO:0010257)2.74402995
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74402995
47phosphatidylinositol acyl-chain remodeling (GO:0036149)2.74343524
48startle response (GO:0001964)2.73920014
49kidney morphogenesis (GO:0060993)2.71573059
50DNA deamination (GO:0045006)2.71429571
51regulation of posttranscriptional gene silencing (GO:0060147)2.70790491
52regulation of gene silencing by miRNA (GO:0060964)2.70790491
53regulation of gene silencing by RNA (GO:0060966)2.70790491
54cornea development in camera-type eye (GO:0061303)2.69965014
55platelet dense granule organization (GO:0060155)2.69145667
56negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.68496907
57negative regulation of translation, ncRNA-mediated (GO:0040033)2.68496907
58regulation of translation, ncRNA-mediated (GO:0045974)2.68496907
59cAMP catabolic process (GO:0006198)2.67613300
60positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.66525086
61piRNA metabolic process (GO:0034587)2.66139843
62cellular biogenic amine catabolic process (GO:0042402)2.65048821
63amine catabolic process (GO:0009310)2.65048821
64cilium movement (GO:0003341)2.64941743
65protein complex biogenesis (GO:0070271)2.64894893
66cilium morphogenesis (GO:0060271)2.64496572
67somite development (GO:0061053)2.62639341
68cilium organization (GO:0044782)2.61295833
69postsynaptic membrane organization (GO:0001941)2.60303825
70action potential (GO:0001508)2.60113367
71alanine transport (GO:0032328)2.59041823
72regulation of mesoderm development (GO:2000380)2.57858762
73membrane depolarization during action potential (GO:0086010)2.56491214
74protein import into peroxisome matrix (GO:0016558)2.55492610
75cilium assembly (GO:0042384)2.55432723
76nucleobase catabolic process (GO:0046113)2.55240846
77detection of mechanical stimulus involved in sensory perception (GO:0050974)2.52703762
78transmission of nerve impulse (GO:0019226)2.51242681
79photoreceptor cell development (GO:0042461)2.51213580
80positive regulation of sodium ion transmembrane transport (GO:1902307)2.50423510
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50007231
82protein-cofactor linkage (GO:0018065)2.49754441
83negative regulation of reactive oxygen species metabolic process (GO:2000378)2.49196161
84cellular response to ATP (GO:0071318)2.45287948
85mitochondrial respiratory chain complex assembly (GO:0033108)2.45226320
86preassembly of GPI anchor in ER membrane (GO:0016254)2.45118061
87axoneme assembly (GO:0035082)2.44343077
88negative regulation of transcription regulatory region DNA binding (GO:2000678)2.44004540
89glycerophospholipid catabolic process (GO:0046475)2.42790840
90parturition (GO:0007567)2.42096720
91negative regulation of DNA-dependent DNA replication (GO:2000104)2.41971031
92protein polyglutamylation (GO:0018095)2.41376725
93regulation of rhodopsin mediated signaling pathway (GO:0022400)2.40541535
94proline transport (GO:0015824)2.39832525
95oxidative demethylation (GO:0070989)2.39348558
96phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.38525248
97phosphatidylserine acyl-chain remodeling (GO:0036150)2.38206996
98renal tubule morphogenesis (GO:0061333)2.36954568
99hindbrain development (GO:0030902)2.36912933
100protein localization to synapse (GO:0035418)2.36700075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.86664123
2ZNF274_21170338_ChIP-Seq_K562_Hela4.01991442
3VDR_22108803_ChIP-Seq_LS180_Human3.42602694
4GBX2_23144817_ChIP-Seq_PC3_Human3.03826174
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.02192187
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60467577
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51979274
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28020490
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.24417847
10TAF15_26573619_Chip-Seq_HEK293_Human2.11349164
11IGF1R_20145208_ChIP-Seq_DFB_Human2.03993891
12POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96058524
13CBX2_27304074_Chip-Seq_ESCs_Mouse1.95169776
14FUS_26573619_Chip-Seq_HEK293_Human1.93848902
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93809968
16EWS_26573619_Chip-Seq_HEK293_Human1.92448292
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89104667
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.85786228
19ER_23166858_ChIP-Seq_MCF-7_Human1.85421238
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84764387
21P300_19829295_ChIP-Seq_ESCs_Human1.84653534
22REST_21632747_ChIP-Seq_MESCs_Mouse1.80946195
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66931739
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.60959718
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59868321
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58409641
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.55736883
28IRF1_19129219_ChIP-ChIP_H3396_Human1.55213656
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55151255
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53335610
31BCAT_22108803_ChIP-Seq_LS180_Human1.52692176
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49710391
33RNF2_27304074_Chip-Seq_NSC_Mouse1.49194587
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49134641
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48781951
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47966214
37STAT3_23295773_ChIP-Seq_U87_Human1.47937527
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46859216
39AR_25329375_ChIP-Seq_VCAP_Human1.46308318
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.45400973
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43801310
42AR_21572438_ChIP-Seq_LNCaP_Human1.42336927
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41869528
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40338892
45TP53_22573176_ChIP-Seq_HFKS_Human1.40318857
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.39737913
47SMAD4_21799915_ChIP-Seq_A2780_Human1.37815327
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35703287
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35543145
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35543145
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35519814
52DROSHA_22980978_ChIP-Seq_HELA_Human1.35461645
53TCF4_23295773_ChIP-Seq_U87_Human1.34069605
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33826869
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.32177526
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30536643
57CBP_20019798_ChIP-Seq_JUKART_Human1.30344861
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30344861
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30059509
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26250265
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.24694138
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23099916
63RUNX2_22187159_ChIP-Seq_PCA_Human1.23040325
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22259350
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20070962
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18813847
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.18813847
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18739144
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18534475
70MYC_18940864_ChIP-ChIP_HL60_Human1.18430367
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.17829783
72NANOG_19829295_ChIP-Seq_ESCs_Human1.17584704
73SOX2_19829295_ChIP-Seq_ESCs_Human1.17584704
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.17048341
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.15561138
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14893134
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.14805914
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13022746
79TP53_16413492_ChIP-PET_HCT116_Human1.12710443
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.12644538
81TCF4_22108803_ChIP-Seq_LS180_Human1.11282211
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.09367220
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08202391
84NCOR_22424771_ChIP-Seq_293T_Human1.05876212
85SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05426588
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04724295
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.03556516
88SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03344380
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.03168903
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02753131
91HOXB7_26014856_ChIP-Seq_BT474_Human1.01439203
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01069875
93AR_20517297_ChIP-Seq_VCAP_Human1.00656810
94KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99628856
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99313307
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99017453
97EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97549176
98RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97549176
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97141664
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.97077139

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.08029176
2MP0003195_calcinosis2.43105354
3MP0005551_abnormal_eye_electrophysiolog2.42077863
4MP0000569_abnormal_digit_pigmentation2.41258613
5MP0008877_abnormal_DNA_methylation2.36712952
6MP0002653_abnormal_ependyma_morphology2.28669245
7MP0001968_abnormal_touch/_nociception2.25610681
8MP0002102_abnormal_ear_morphology2.17578546
9MP0003646_muscle_fatigue2.16512753
10MP0004142_abnormal_muscle_tone2.13677559
11MP0009745_abnormal_behavioral_response2.12108523
12MP0009046_muscle_twitch2.09148281
13MP0004133_heterotaxia2.01682225
14MP0004885_abnormal_endolymph1.90742786
15MP0006292_abnormal_olfactory_placode1.86149353
16MP0002272_abnormal_nervous_system1.86134562
17MP0003787_abnormal_imprinting1.79530562
18MP0003880_abnormal_central_pattern1.79053810
19MP0001485_abnormal_pinna_reflex1.78794143
20MP0002837_dystrophic_cardiac_calcinosis1.77231256
21MP0001986_abnormal_taste_sensitivity1.76422106
22MP0002638_abnormal_pupillary_reflex1.73573565
23MP0008872_abnormal_physiological_respon1.71049494
24MP0003011_delayed_dark_adaptation1.70877561
25MP0000427_abnormal_hair_cycle1.69434309
26MP0008875_abnormal_xenobiotic_pharmacok1.68690799
27MP0006276_abnormal_autonomic_nervous1.68088060
28MP0002064_seizures1.67626010
29MP0002736_abnormal_nociception_after1.66826970
30MP0006072_abnormal_retinal_apoptosis1.65142426
31MP0002938_white_spotting1.61861657
32MP0000631_abnormal_neuroendocrine_gland1.59357629
33MP0002572_abnormal_emotion/affect_behav1.58383091
34MP0004742_abnormal_vestibular_system1.55247635
35MP0004043_abnormal_pH_regulation1.55035171
36MP0002876_abnormal_thyroid_physiology1.54912393
37MP0005646_abnormal_pituitary_gland1.50451266
38MP0002735_abnormal_chemical_nociception1.50098266
39MP0001501_abnormal_sleep_pattern1.49147944
40MP0005253_abnormal_eye_physiology1.46536459
41MP0009379_abnormal_foot_pigmentation1.46269438
42MP0005645_abnormal_hypothalamus_physiol1.45731235
43MP0004145_abnormal_muscle_electrophysio1.43827782
44MP0002733_abnormal_thermal_nociception1.43814926
45MP0001486_abnormal_startle_reflex1.43613641
46MP0000372_irregular_coat_pigmentation1.42936616
47MP0003635_abnormal_synaptic_transmissio1.41701968
48MP0005174_abnormal_tail_pigmentation1.38837424
49MP0004147_increased_porphyrin_level1.38257205
50MP0001970_abnormal_pain_threshold1.37969938
51MP0003283_abnormal_digestive_organ1.36290293
52MP0002557_abnormal_social/conspecific_i1.36012551
53MP0002063_abnormal_learning/memory/cond1.33858003
54MP0002067_abnormal_sensory_capabilities1.32169673
55MP0005084_abnormal_gallbladder_morpholo1.30531584
56MP0003878_abnormal_ear_physiology1.26068040
57MP0005377_hearing/vestibular/ear_phenot1.26068040
58MP0000778_abnormal_nervous_system1.25664114
59MP0002163_abnormal_gland_morphology1.24194064
60MP0010386_abnormal_urinary_bladder1.22661601
61MP0004924_abnormal_behavior1.22541790
62MP0005386_behavior/neurological_phenoty1.22541790
63MP0002928_abnormal_bile_duct1.21650470
64MP0001919_abnormal_reproductive_system1.20850189
65MP0002734_abnormal_mechanical_nocicepti1.20357636
66MP0003890_abnormal_embryonic-extraembry1.20147302
67MP0005389_reproductive_system_phenotype1.18048926
68MP0000566_synostosis1.16089788
69MP0005195_abnormal_posterior_eye1.14610778
70MP0005423_abnormal_somatic_nervous1.13989853
71MP0002277_abnormal_respiratory_mucosa1.13412771
72MP0002234_abnormal_pharynx_morphology1.12591552
73MP0004130_abnormal_muscle_cell1.08410699
74MP0002160_abnormal_reproductive_system1.06532158
75MP0000026_abnormal_inner_ear1.05611834
76MP0001529_abnormal_vocalization1.04906611
77MP0002095_abnormal_skin_pigmentation1.02057131
78MP0002752_abnormal_somatic_nervous0.98666466
79MP0000383_abnormal_hair_follicle0.98543404
80MP0001905_abnormal_dopamine_level0.95568473
81MP0003137_abnormal_impulse_conducting0.94608340
82MP0001324_abnormal_eye_pigmentation0.93810367
83MP0002184_abnormal_innervation0.92811136
84MP0001440_abnormal_grooming_behavior0.92778770
85MP0003119_abnormal_digestive_system0.92673897
86MP0005379_endocrine/exocrine_gland_phen0.89864966
87MP0003122_maternal_imprinting0.89789886
88MP0005085_abnormal_gallbladder_physiolo0.88835932
89MP0000955_abnormal_spinal_cord0.86767112
90MP0001873_stomach_inflammation0.86002853
91MP0001293_anophthalmia0.85465208
92MP0001963_abnormal_hearing_physiology0.84471704
93MP0000230_abnormal_systemic_arterial0.84030346
94MP0005448_abnormal_energy_balance0.83808790
95MP0003121_genomic_imprinting0.82525493
96MP0002882_abnormal_neuron_morphology0.81737658
97MP0005171_absent_coat_pigmentation0.80891070
98MP0001984_abnormal_olfaction0.80090725
99MP0005167_abnormal_blood-brain_barrier0.78059141
100MP0003698_abnormal_male_reproductive0.77457023

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.70513887
2Abnormality of midbrain morphology (HP:0002418)4.56609147
3Molar tooth sign on MRI (HP:0002419)4.56609147
4Pancreatic fibrosis (HP:0100732)4.45177053
5True hermaphroditism (HP:0010459)4.26459131
6Nephronophthisis (HP:0000090)4.14303986
7Congenital stationary night blindness (HP:0007642)3.85385847
8Hyperventilation (HP:0002883)3.46366892
9Abnormality of the renal medulla (HP:0100957)3.41008339
10Chronic hepatic failure (HP:0100626)3.15186804
11Cystic liver disease (HP:0006706)3.06865047
12Medial flaring of the eyebrow (HP:0010747)3.06091102
13Type II lissencephaly (HP:0007260)3.04347304
14Abnormality of the renal cortex (HP:0011035)3.00084300
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.93699047
16Abnormality of alanine metabolism (HP:0010916)2.93699047
17Hyperalaninemia (HP:0003348)2.93699047
18Concave nail (HP:0001598)2.89964865
19Congenital, generalized hypertrichosis (HP:0004540)2.89398787
20Tubular atrophy (HP:0000092)2.88815818
21Sclerocornea (HP:0000647)2.81280159
22Attenuation of retinal blood vessels (HP:0007843)2.77930980
23Large for gestational age (HP:0001520)2.77487701
24Protruding tongue (HP:0010808)2.77251147
25Progressive cerebellar ataxia (HP:0002073)2.76646632
26Genetic anticipation (HP:0003743)2.68792655
27Birth length less than 3rd percentile (HP:0003561)2.66258738
28Inability to walk (HP:0002540)2.64660973
29Furrowed tongue (HP:0000221)2.63045548
30Gait imbalance (HP:0002141)2.57406305
31Abnormal drinking behavior (HP:0030082)2.53127498
32Polydipsia (HP:0001959)2.53127498
33Abolished electroretinogram (ERG) (HP:0000550)2.48591694
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.46864806
35Absent/shortened dynein arms (HP:0200106)2.46864806
36Patellar aplasia (HP:0006443)2.44004634
37Pendular nystagmus (HP:0012043)2.41313694
38Anencephaly (HP:0002323)2.38198222
39Keratoconus (HP:0000563)2.36955205
40Increased corneal curvature (HP:0100692)2.36955205
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.36484140
42Congenital primary aphakia (HP:0007707)2.33425250
43Congenital hepatic fibrosis (HP:0002612)2.32818206
44Clumsiness (HP:0002312)2.32775968
45Lissencephaly (HP:0001339)2.30754230
46Aplasia/Hypoplasia of the patella (HP:0006498)2.30641856
47Male pseudohermaphroditism (HP:0000037)2.28478536
48Progressive inability to walk (HP:0002505)2.26346501
49Abnormal respiratory motile cilium morphology (HP:0005938)2.24108806
50Abnormal respiratory epithelium morphology (HP:0012253)2.24108806
51Nephrogenic diabetes insipidus (HP:0009806)2.21373072
52Gaze-evoked nystagmus (HP:0000640)2.19372125
53Focal motor seizures (HP:0011153)2.16405710
54Abnormality of the pons (HP:0007361)2.13206280
55Abnormal rod and cone electroretinograms (HP:0008323)2.10857227
56Broad-based gait (HP:0002136)2.09268829
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.07771339
58Bile duct proliferation (HP:0001408)2.07335413
59Abnormal biliary tract physiology (HP:0012439)2.07335413
60Decreased central vision (HP:0007663)2.07220901
61Cerebellar dysplasia (HP:0007033)2.07168150
62Decreased circulating renin level (HP:0003351)2.04397536
63Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03007658
64Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02945618
65Hypoplasia of the pons (HP:0012110)2.02910207
66Postaxial foot polydactyly (HP:0001830)1.98947042
67Febrile seizures (HP:0002373)1.96560942
68Genital tract atresia (HP:0001827)1.96166475
69Optic nerve hypoplasia (HP:0000609)1.95270303
70Polyuria (HP:0000103)1.93395560
71Severe muscular hypotonia (HP:0006829)1.93314166
72Vaginal atresia (HP:0000148)1.92895897
73Poor coordination (HP:0002370)1.92260721
74Renal cortical cysts (HP:0000803)1.91016624
75Hyperglycinuria (HP:0003108)1.90734869
76Agitation (HP:0000713)1.87894756
77Bony spicule pigmentary retinopathy (HP:0007737)1.87892377
78Limb dystonia (HP:0002451)1.87390150
79Optic disc pallor (HP:0000543)1.87389311
80Focal seizures (HP:0007359)1.86086982
81Fair hair (HP:0002286)1.84347767
82Acute necrotizing encephalopathy (HP:0006965)1.83279710
83Oligodactyly (hands) (HP:0001180)1.82608365
84Congenital sensorineural hearing impairment (HP:0008527)1.82510392
853-Methylglutaconic aciduria (HP:0003535)1.82372048
86Tachypnea (HP:0002789)1.80391316
87Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80354082
88Hemiparesis (HP:0001269)1.80174173
89Chorioretinal atrophy (HP:0000533)1.80133095
90Septo-optic dysplasia (HP:0100842)1.79800106
91Abnormal ciliary motility (HP:0012262)1.79465929
92Partial agenesis of the corpus callosum (HP:0001338)1.79307282
93Pachygyria (HP:0001302)1.78069697
94Dialeptic seizures (HP:0011146)1.74081110
95Mitochondrial inheritance (HP:0001427)1.73918426
96Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73794218
97Bilateral microphthalmos (HP:0007633)1.71979164
98Abnormal number of erythroid precursors (HP:0012131)1.69771787
99Prominent supraorbital ridges (HP:0000336)1.69704386
100Postaxial hand polydactyly (HP:0001162)1.68795658

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.09406610
2INSRR3.47670310
3BMPR1B3.42098468
4ADRBK23.41039021
5CASK2.78320966
6ACVR1B2.78189555
7WNK42.60868236
8GRK12.45701142
9WNK32.43960228
10ZAK2.35425768
11PNCK2.26791004
12TLK12.22371368
13MAPK132.22231779
14PINK12.20294798
15MARK11.99327054
16TAOK31.79374129
17MAP3K41.77635441
18MAP4K21.76827577
19TNIK1.66043919
20TXK1.54403759
21OXSR11.53231766
22DAPK21.50747493
23MAPK151.46586100
24NUAK11.41832530
25CAMKK21.40293142
26TGFBR11.40084508
27ADRBK11.37362324
28NTRK31.35275740
29DYRK21.33451142
30STK391.22898054
31NTRK21.15534912
32PRKCG1.15523550
33MAP2K71.06205636
34MKNK21.04266642
35PAK31.03053580
36SIK20.98763210
37PIK3CA0.98375502
38WEE10.91684030
39MUSK0.82487533
40TYRO30.81564699
41NEK20.80647925
42PKN10.80261001
43PRKCE0.78433621
44PHKG20.78161045
45PHKG10.78161045
46TIE10.76912666
47PRKCQ0.74271404
48STK110.72630785
49MAPKAPK50.70233335
50MAPKAPK30.68005201
51CAMK2A0.67243129
52PTK2B0.65963230
53STK30.65055299
54CDK190.62064777
55RPS6KA50.61819714
56CAMK10.60076887
57MAP2K60.56104971
58CHUK0.54947111
59CAMKK10.53941501
60PRKACA0.53880740
61VRK10.52169163
62OBSCN0.50259089
63RPS6KA60.48684776
64PRKCZ0.47458986
65CSNK1G20.47023386
66NME10.46872019
67TEC0.46640269
68CAMK1D0.43382117
69DYRK1A0.42835727
70CAMK40.42639610
71CHEK20.42625975
72IRAK10.42532379
73TRIM280.42468870
74IKBKB0.41662889
75MAP2K40.41054637
76PLK40.40831328
77LIMK10.40257857
78CSNK1A10.39251045
79PLK20.38970591
80BRSK20.38803931
81MAP2K10.38075413
82PRKCA0.37449969
83PRKG10.35811788
84MKNK10.34825886
85PRKCH0.34534483
86STK38L0.34441612
87WNK10.33952602
88ERBB20.32735525
89MAP3K90.32437276
90BCKDK0.32270742
91ITK0.32246863
92SGK20.32239907
93PRKAA20.32144528
94CAMK1G0.31727816
95GRK70.31187735
96BCR0.31169661
97CSNK1D0.30796702
98EPHA40.30739387
99TAF10.30310407
100CDK30.30056074

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.06096290
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.95962824
3Nicotine addiction_Homo sapiens_hsa050332.85178500
4Phototransduction_Homo sapiens_hsa047442.81860241
5Nitrogen metabolism_Homo sapiens_hsa009102.49103532
6Butanoate metabolism_Homo sapiens_hsa006502.39607184
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35560929
8Oxidative phosphorylation_Homo sapiens_hsa001902.29572924
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.24388351
10Selenocompound metabolism_Homo sapiens_hsa004502.18438558
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.16916926
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09184406
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.03963299
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93469873
15Ether lipid metabolism_Homo sapiens_hsa005651.92306629
16Tryptophan metabolism_Homo sapiens_hsa003801.76348630
17Olfactory transduction_Homo sapiens_hsa047401.72706028
18Parkinsons disease_Homo sapiens_hsa050121.72570658
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72268204
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69250790
21Taste transduction_Homo sapiens_hsa047421.66171395
22Cardiac muscle contraction_Homo sapiens_hsa042601.63746794
23Morphine addiction_Homo sapiens_hsa050321.61784080
24Homologous recombination_Homo sapiens_hsa034401.44630826
25Caffeine metabolism_Homo sapiens_hsa002321.39718345
26RNA polymerase_Homo sapiens_hsa030201.33472491
27ABC transporters_Homo sapiens_hsa020101.30168986
28Glutamatergic synapse_Homo sapiens_hsa047241.28422448
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27718022
30Chemical carcinogenesis_Homo sapiens_hsa052041.23412617
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.22907766
32GABAergic synapse_Homo sapiens_hsa047271.22109539
33Insulin secretion_Homo sapiens_hsa049111.21899392
34Circadian entrainment_Homo sapiens_hsa047131.20642374
35Huntingtons disease_Homo sapiens_hsa050161.20438887
36Alzheimers disease_Homo sapiens_hsa050101.19959276
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19319970
38Arachidonic acid metabolism_Homo sapiens_hsa005901.18698865
39Fanconi anemia pathway_Homo sapiens_hsa034601.17955417
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.17597321
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16862139
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.15502974
43Serotonergic synapse_Homo sapiens_hsa047261.13782677
44Protein export_Homo sapiens_hsa030601.13450169
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10898809
46Basal transcription factors_Homo sapiens_hsa030221.09503420
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08513281
48Ovarian steroidogenesis_Homo sapiens_hsa049131.06334665
49Sulfur relay system_Homo sapiens_hsa041221.01582278
50Ribosome_Homo sapiens_hsa030101.00820308
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00239921
52Calcium signaling pathway_Homo sapiens_hsa040200.96615105
53Cocaine addiction_Homo sapiens_hsa050300.93658341
54Peroxisome_Homo sapiens_hsa041460.92103954
55Retinol metabolism_Homo sapiens_hsa008300.91969435
56Fat digestion and absorption_Homo sapiens_hsa049750.86285766
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84928241
58Propanoate metabolism_Homo sapiens_hsa006400.84172315
59RNA degradation_Homo sapiens_hsa030180.79179708
60Histidine metabolism_Homo sapiens_hsa003400.78180157
61Salivary secretion_Homo sapiens_hsa049700.74922943
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74853209
63One carbon pool by folate_Homo sapiens_hsa006700.74844018
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73087001
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.73011945
66Dopaminergic synapse_Homo sapiens_hsa047280.72612526
67Glycerolipid metabolism_Homo sapiens_hsa005610.71861387
68Cholinergic synapse_Homo sapiens_hsa047250.71124074
69Amphetamine addiction_Homo sapiens_hsa050310.65372350
70Gastric acid secretion_Homo sapiens_hsa049710.65157540
71Long-term depression_Homo sapiens_hsa047300.64382317
72Fatty acid biosynthesis_Homo sapiens_hsa000610.63538708
73beta-Alanine metabolism_Homo sapiens_hsa004100.62554729
74Regulation of autophagy_Homo sapiens_hsa041400.59704947
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56629127
76Basal cell carcinoma_Homo sapiens_hsa052170.55953108
77Asthma_Homo sapiens_hsa053100.55725669
78Hedgehog signaling pathway_Homo sapiens_hsa043400.54605181
79cAMP signaling pathway_Homo sapiens_hsa040240.54006075
80Mineral absorption_Homo sapiens_hsa049780.53667486
81Vitamin digestion and absorption_Homo sapiens_hsa049770.52341318
82Oxytocin signaling pathway_Homo sapiens_hsa049210.50626095
83Metabolic pathways_Homo sapiens_hsa011000.48261673
84Collecting duct acid secretion_Homo sapiens_hsa049660.47736275
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47074073
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45083574
87Axon guidance_Homo sapiens_hsa043600.44587295
88Steroid biosynthesis_Homo sapiens_hsa001000.43845674
89Purine metabolism_Homo sapiens_hsa002300.41151157
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38594418
91Sulfur metabolism_Homo sapiens_hsa009200.38020663
92Primary immunodeficiency_Homo sapiens_hsa053400.37875432
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.37802754
94Dorso-ventral axis formation_Homo sapiens_hsa043200.37065890
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35105077
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34205060
97Bile secretion_Homo sapiens_hsa049760.33434205
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32052197
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30094541
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29780516

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