HEPACAM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.33650920
2central nervous system myelination (GO:0022010)8.33650920
3membrane repolarization during cardiac muscle cell action potential (GO:0086013)7.23009793
4membrane repolarization during action potential (GO:0086011)6.48896705
5L-amino acid import (GO:0043092)6.04992793
6behavioral response to nicotine (GO:0035095)5.41161792
7amino acid import (GO:0043090)5.20743778
8DNA deamination (GO:0045006)5.02271419
9cellular potassium ion homeostasis (GO:0030007)4.68019710
10regulation of membrane repolarization (GO:0060306)4.48726637
11myelination (GO:0042552)4.48149934
12positive regulation of synapse maturation (GO:0090129)4.44268583
13axon ensheathment (GO:0008366)4.41688292
14ensheathment of neurons (GO:0007272)4.41688292
15C4-dicarboxylate transport (GO:0015740)4.32495291
16sodium ion export (GO:0071436)4.30150061
17water-soluble vitamin biosynthetic process (GO:0042364)4.23865889
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.23025679
19neurotransmitter uptake (GO:0001504)4.20880452
20gamma-aminobutyric acid transport (GO:0015812)4.13309553
21regulation of synapse maturation (GO:0090128)4.10278972
22fatty acid elongation (GO:0030497)4.07157355
23oligodendrocyte differentiation (GO:0048709)4.05616679
24positive regulation of endothelial cell differentiation (GO:0045603)3.98668632
25membrane depolarization during action potential (GO:0086010)3.94530207
26potassium ion import (GO:0010107)3.92949204
27serotonin metabolic process (GO:0042428)3.91681543
28primary amino compound metabolic process (GO:1901160)3.81731184
29cellular response to cholesterol (GO:0071397)3.80542909
30regulation of skeletal muscle contraction (GO:0014819)3.73760759
31locomotory exploration behavior (GO:0035641)3.73307072
32myelin maintenance (GO:0043217)3.70355070
33negative regulation of astrocyte differentiation (GO:0048712)3.70158907
34positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.67852057
35response to auditory stimulus (GO:0010996)3.64809059
36magnesium ion transport (GO:0015693)3.64387742
37negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.63198159
38synaptic vesicle maturation (GO:0016188)3.61454792
39regulation of endothelial cell differentiation (GO:0045601)3.56503534
40regulation of beta-amyloid formation (GO:1902003)3.55218650
41regulation of heart rate by cardiac conduction (GO:0086091)3.54579370
42cAMP catabolic process (GO:0006198)3.51475616
43L-serine transport (GO:0015825)3.51015920
44potassium ion homeostasis (GO:0055075)3.50353204
45myelination in peripheral nervous system (GO:0022011)3.48033196
46peripheral nervous system axon ensheathment (GO:0032292)3.48033196
47transmission of nerve impulse (GO:0019226)3.47211546
48neuronal action potential propagation (GO:0019227)3.44397413
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.42624161
50NADH dehydrogenase complex assembly (GO:0010257)3.42624161
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42624161
52regulation of mesoderm development (GO:2000380)3.40317887
53regulation of female receptivity (GO:0045924)3.36993166
54neuron cell-cell adhesion (GO:0007158)3.36239783
55neurotransmitter-gated ion channel clustering (GO:0072578)3.35925365
56cyclic nucleotide catabolic process (GO:0009214)3.33235235
57negative regulation of neurotransmitter transport (GO:0051589)3.31708579
58cellular response to electrical stimulus (GO:0071257)3.31599570
59acidic amino acid transport (GO:0015800)3.30317685
60alanine transport (GO:0032328)3.29957231
61negative regulation of protein localization to cell surface (GO:2000009)3.29590357
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.27577656
63regulation of amyloid precursor protein catabolic process (GO:1902991)3.22872758
64regulation of potassium ion transmembrane transport (GO:1901379)3.21333561
65auditory behavior (GO:0031223)3.21200102
66positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.18957222
67layer formation in cerebral cortex (GO:0021819)3.17110292
68presynaptic membrane organization (GO:0097090)3.16992379
69synaptic vesicle exocytosis (GO:0016079)3.15519213
70glycine transport (GO:0015816)3.15138155
71negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14773484
72cellular sodium ion homeostasis (GO:0006883)3.14651770
73cerebellar granule cell differentiation (GO:0021707)3.13595537
74regulation of germinal center formation (GO:0002634)3.12969185
75cellular response to sterol (GO:0036315)3.12794685
76cardiac conduction (GO:0061337)3.12632600
77positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11757175
78protein complex biogenesis (GO:0070271)3.10895013
79cerebral cortex radially oriented cell migration (GO:0021799)3.10595150
80glutamate secretion (GO:0014047)3.10554636
81presynaptic membrane assembly (GO:0097105)3.08308573
82indolalkylamine metabolic process (GO:0006586)3.08216573
83positive regulation of potassium ion transmembrane transport (GO:1901381)3.08069398
84regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.06791330
85cell communication by electrical coupling (GO:0010644)3.06779660
86ionotropic glutamate receptor signaling pathway (GO:0035235)3.05983441
87multicellular organismal signaling (GO:0035637)3.05136602
88adult walking behavior (GO:0007628)3.04800138
89L-glutamate transport (GO:0015813)3.03795404
90cellular anion homeostasis (GO:0030002)3.01836240
91parturition (GO:0007567)2.99512185
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98316852
93sulfation (GO:0051923)2.97500599
94positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.97335998
95astrocyte development (GO:0014002)2.97079146
96glutamate receptor signaling pathway (GO:0007215)2.96822139
97postsynaptic membrane organization (GO:0001941)2.96661898
98cellular response to exogenous dsRNA (GO:0071360)2.95940603
99serine transport (GO:0032329)2.95022775
100photoreceptor cell differentiation (GO:0046530)2.94555415
101eye photoreceptor cell differentiation (GO:0001754)2.94555415
102transepithelial transport (GO:0070633)2.93253467
103regulation of phospholipid biosynthetic process (GO:0071071)2.90197893
104negative regulation of neurotransmitter secretion (GO:0046929)2.90062147
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89178208
106regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.88045995
107negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.87950559
108regulation of astrocyte differentiation (GO:0048710)2.87622079
109regulation of short-term neuronal synaptic plasticity (GO:0048172)2.86780823
110import into cell (GO:0098657)2.85404539
111long-chain fatty acid biosynthetic process (GO:0042759)2.84869767
112relaxation of cardiac muscle (GO:0055119)2.83650639
113positive regulation of potassium ion transport (GO:0043268)2.83294598
114synaptic transmission, glutamatergic (GO:0035249)2.82393673
115indole-containing compound metabolic process (GO:0042430)2.82198016
116vocalization behavior (GO:0071625)2.81939446
117regulation of neuronal synaptic plasticity (GO:0048168)2.80443287
118chondroitin sulfate catabolic process (GO:0030207)2.78771334
119DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.78703020
120cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.77825050
121dendrite morphogenesis (GO:0048813)2.76799821
122negative regulation of mast cell activation (GO:0033004)2.76426002
123female mating behavior (GO:0060180)2.76350724
124positive regulation of cellular amide metabolic process (GO:0034250)2.76229064
125positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.75631987
126lymphangiogenesis (GO:0001946)2.74794406
127neuroblast proliferation (GO:0007405)2.74317359
128positive regulation of fatty acid oxidation (GO:0046321)2.74040871
129mechanosensory behavior (GO:0007638)2.73492350
130regulation of glomerulus development (GO:0090192)2.73132312
131mitochondrial respiratory chain complex assembly (GO:0033108)2.72714029
132negative regulation of response to food (GO:0032096)2.71736767
133negative regulation of appetite (GO:0032099)2.71736767
134response to methylmercury (GO:0051597)2.71202301
135cell proliferation in forebrain (GO:0021846)2.70813876
136positive regulation of defense response to virus by host (GO:0002230)2.69834535
137protein polyglutamylation (GO:0018095)2.69672129
138neuronal ion channel clustering (GO:0045161)2.69238359
139positive regulation of cardiac muscle cell differentiation (GO:2000727)2.66693409
140regulation of neurotransmitter uptake (GO:0051580)2.65724768
141membrane depolarization (GO:0051899)2.64276353
142response to lipoprotein particle (GO:0055094)2.63815110
143regulation of synaptic transmission, glutamatergic (GO:0051966)2.63704314
144dendritic spine morphogenesis (GO:0060997)2.63439925
145membrane repolarization (GO:0086009)2.62857707
146organ formation (GO:0048645)2.62372779
147long-term memory (GO:0007616)2.61914841
148regulation of synaptic vesicle exocytosis (GO:2000300)2.61703142
149cellular response to ATP (GO:0071318)2.61495844
150long-term synaptic potentiation (GO:0060291)2.59386007
151somite development (GO:0061053)2.58797607
152negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57161329
153long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.56670027
154negative regulation of membrane potential (GO:0045837)2.55536088
155asymmetric protein localization (GO:0008105)2.55330552
156substantia nigra development (GO:0021762)2.54906318
157protein localization to synapse (GO:0035418)2.53815063
158ovulation cycle (GO:0042698)2.53024813
159neurotransmitter catabolic process (GO:0042135)2.51866232
160neurotransmitter secretion (GO:0007269)2.51762344
161response to dietary excess (GO:0002021)2.51480315
162artery development (GO:0060840)2.49513656
163action potential (GO:0001508)2.48826723
164gamma-aminobutyric acid signaling pathway (GO:0007214)2.47950904
165negative regulation of systemic arterial blood pressure (GO:0003085)2.47369692
166spinal cord development (GO:0021510)2.46383386
167synaptic transmission, cholinergic (GO:0007271)2.45662994
168regulation of memory T cell differentiation (GO:0043380)2.44849652
169positive regulation of triglyceride biosynthetic process (GO:0010867)2.43798154
170negative regulation of T cell differentiation in thymus (GO:0033085)2.43583043
171behavioral fear response (GO:0001662)2.43383554
172behavioral defense response (GO:0002209)2.43383554
173regulation of hippo signaling (GO:0035330)2.38768171
174middle ear morphogenesis (GO:0042474)2.38372878
175dentate gyrus development (GO:0021542)2.36183391
176nephron tubule morphogenesis (GO:0072078)2.32675215
177nephron epithelium morphogenesis (GO:0072088)2.32675215
178regulation of triglyceride biosynthetic process (GO:0010866)2.31960712
179DNA damage response, signal transduction resulting in transcription (GO:0042772)2.31279348
180vitamin biosynthetic process (GO:0009110)2.30758430
181negative regulation of telomere maintenance (GO:0032205)2.30446542
182positive regulation of fatty acid beta-oxidation (GO:0032000)2.29769208
183fear response (GO:0042596)2.29433564

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.02812916
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97427072
3GBX2_23144817_ChIP-Seq_PC3_Human2.90041107
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88128499
5VDR_22108803_ChIP-Seq_LS180_Human2.83661409
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69045017
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61383960
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49499688
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49499688
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47845869
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46381560
12AR_21572438_ChIP-Seq_LNCaP_Human2.40898283
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.39339312
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36238025
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34706590
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33656496
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30010617
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.28211931
19DROSHA_22980978_ChIP-Seq_HELA_Human2.23014713
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.18834646
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10656503
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.09075833
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02001741
24REST_21632747_ChIP-Seq_MESCs_Mouse2.00158689
25ZNF274_21170338_ChIP-Seq_K562_Hela1.92461708
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87773648
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85481742
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.84295985
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64497149
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58980726
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58837777
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57909261
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.56419465
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55388112
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54647982
36RNF2_27304074_Chip-Seq_NSC_Mouse1.53529965
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52347958
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51769451
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48898775
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48351080
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.46880692
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43340773
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41976399
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.41448544
45IRF1_19129219_ChIP-ChIP_H3396_Human1.38575504
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38388911
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34261602
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.31959584
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31935942
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31449638
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.30793217
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29073472
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.27453131
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.24243241
55SMAD4_21799915_ChIP-Seq_A2780_Human1.21198653
56P300_19829295_ChIP-Seq_ESCs_Human1.20719416
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20663656
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20372580
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20184955
60IGF1R_20145208_ChIP-Seq_DFB_Human1.19061853
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17100742
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16694221
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16522144
64TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12920216
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12330274
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.09772068
67STAT3_23295773_ChIP-Seq_U87_Human1.09099524
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08651679
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08296878
70EWS_26573619_Chip-Seq_HEK293_Human1.08082541
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05470400
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05402283
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05155401
74RXR_22108803_ChIP-Seq_LS180_Human1.05143560
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.04531790
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03567160
77AHR_22903824_ChIP-Seq_MCF-7_Human1.03455089
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.02979920
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02607753
80TP53_16413492_ChIP-PET_HCT116_Human1.02360817
81TAF15_26573619_Chip-Seq_HEK293_Human1.01947342
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.01817785
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01645583
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01035260
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00388662
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00388662
87AR_25329375_ChIP-Seq_VCAP_Human1.00114513
88NANOG_19829295_ChIP-Seq_ESCs_Human0.99858750
89SOX2_19829295_ChIP-Seq_ESCs_Human0.99858750
90SMAD4_21741376_ChIP-Seq_EPCs_Human0.99773588
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99574096
92CBP_20019798_ChIP-Seq_JUKART_Human0.99574096
93AR_19668381_ChIP-Seq_PC3_Human0.99139166
94ESR2_21235772_ChIP-Seq_MCF-7_Human0.98814167
95SMAD_19615063_ChIP-ChIP_OVARY_Human0.98189142
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98159391
97DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97106255
98ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96810528
99ER_23166858_ChIP-Seq_MCF-7_Human0.96391843
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96133484
101FLI1_21867929_ChIP-Seq_TH2_Mouse0.95685134
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95293893
103TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95199159
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95142847
105TRIM28_21343339_ChIP-Seq_HEK293_Human0.94939049
106TP53_18474530_ChIP-ChIP_U2OS_Human0.94793591
107P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94714389
108PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94439762
109FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93419818
110FOXA1_25329375_ChIP-Seq_VCAP_Human0.93419818
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92754544
112SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92405479
113KDM2B_26808549_Chip-Seq_REH_Human0.91398759
114TCF4_22108803_ChIP-Seq_LS180_Human0.90950843
115TCF4_23295773_ChIP-Seq_U87_Human0.90916597
116STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90267350
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89828951
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89374734
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.89360305
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88985763
121PRDM14_20953172_ChIP-Seq_ESCs_Human0.88733494
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.87155388
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86607192
124OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86359047
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85940488
126RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85281003
127RUNX2_22187159_ChIP-Seq_PCA_Human0.85154783
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84874437
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84833533
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84484546
131STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84335965
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83880658
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83880658
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.83254205
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83020655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ4.89136111
2MP0004859_abnormal_synaptic_plasticity4.14174868
3MP0003690_abnormal_glial_cell3.62680207
4MP0003880_abnormal_central_pattern3.54083455
5MP0003329_amyloid_beta_deposits3.38318636
6MP0004270_analgesia3.34674161
7MP0000920_abnormal_myelination3.21486140
8MP0004885_abnormal_endolymph3.09213543
9MP0001486_abnormal_startle_reflex2.99276445
10MP0003635_abnormal_synaptic_transmissio2.90015816
11MP0005423_abnormal_somatic_nervous2.86701563
12MP0003879_abnormal_hair_cell2.85126956
13MP0002064_seizures2.70728216
14MP0009046_muscle_twitch2.51323152
15MP0009745_abnormal_behavioral_response2.46672694
16MP0002272_abnormal_nervous_system2.35158852
17MP0003634_abnormal_glial_cell2.31225854
18MP0002876_abnormal_thyroid_physiology2.24590884
19MP0002063_abnormal_learning/memory/cond2.21157845
20MP0002138_abnormal_hepatobiliary_system2.20945026
21MP0003136_yellow_coat_color2.20021484
22MP0005646_abnormal_pituitary_gland2.18955853
23MP0002572_abnormal_emotion/affect_behav2.11351670
24MP0002734_abnormal_mechanical_nocicepti2.10964327
25MP0004858_abnormal_nervous_system2.10268070
26MP0008569_lethality_at_weaning2.10056452
27MP0000778_abnormal_nervous_system1.99597202
28MP0001440_abnormal_grooming_behavior1.94823622
29MP0006292_abnormal_olfactory_placode1.93176306
30MP0004142_abnormal_muscle_tone1.87493936
31MP0001485_abnormal_pinna_reflex1.85094577
32MP0003632_abnormal_nervous_system1.81679387
33MP0004130_abnormal_muscle_cell1.77202840
34MP0000604_amyloidosis1.76841205
35MP0003633_abnormal_nervous_system1.76610061
36MP0003631_nervous_system_phenotype1.69244023
37MP0002733_abnormal_thermal_nociception1.68416948
38MP0002102_abnormal_ear_morphology1.67865075
39MP0001905_abnormal_dopamine_level1.67004499
40MP0001502_abnormal_circadian_rhythm1.66703683
41MP0003195_calcinosis1.66048971
42MP0003950_abnormal_plasma_membrane1.64807371
43MP0001968_abnormal_touch/_nociception1.61861701
44MP0002067_abnormal_sensory_capabilities1.61472119
45MP0009780_abnormal_chondrocyte_physiolo1.59431824
46MP0001970_abnormal_pain_threshold1.58684741
47MP0000049_abnormal_middle_ear1.58339718
48MP0005171_absent_coat_pigmentation1.57621499
49MP0001529_abnormal_vocalization1.56708936
50MP0000955_abnormal_spinal_cord1.52224736
51MP0002160_abnormal_reproductive_system1.51879687
52MP0005645_abnormal_hypothalamus_physiol1.47621265
53MP0001501_abnormal_sleep_pattern1.44759863
54MP0005551_abnormal_eye_electrophysiolog1.44563971
55MP0002837_dystrophic_cardiac_calcinosis1.43087610
56MP0002882_abnormal_neuron_morphology1.42040719
57MP0008877_abnormal_DNA_methylation1.41492085
58MP0003646_muscle_fatigue1.40839289
59MP0002229_neurodegeneration1.39994671
60MP0004742_abnormal_vestibular_system1.39765976
61MP0002557_abnormal_social/conspecific_i1.39101624
62MP0008775_abnormal_heart_ventricle1.36766144
63MP0001986_abnormal_taste_sensitivity1.35632713
64MP0002736_abnormal_nociception_after1.35070903
65MP0000566_synostosis1.34512662
66MP0003119_abnormal_digestive_system1.33236245
67MP0002638_abnormal_pupillary_reflex1.32309901
68MP0006276_abnormal_autonomic_nervous1.31527736
69MP0005386_behavior/neurological_phenoty1.31141231
70MP0004924_abnormal_behavior1.31141231
71MP0009840_abnormal_foam_cell1.30399399
72MP0005410_abnormal_fertilization1.30373010
73MP0003075_altered_response_to1.29767245
74MP0002066_abnormal_motor_capabilities/c1.29638615
75MP0005389_reproductive_system_phenotype1.28674248
76MP0004145_abnormal_muscle_electrophysio1.22097621
77MP0001984_abnormal_olfaction1.20566565
78MP0008872_abnormal_physiological_respon1.20325511
79MP0002254_reproductive_system_inflammat1.17939801
80MP0009384_cardiac_valve_regurgitation1.17291571
81MP0002090_abnormal_vision1.15184528
82MP0004043_abnormal_pH_regulation1.15167597
83MP0001963_abnormal_hearing_physiology1.13237970
84MP0004133_heterotaxia1.09428073
85MP0002152_abnormal_brain_morphology1.09286653
86MP0008875_abnormal_xenobiotic_pharmacok1.09150053
87MP0001299_abnormal_eye_distance/1.08529933
88MP0002822_catalepsy1.07092944
89MP0009379_abnormal_foot_pigmentation1.03943262
90MP0005167_abnormal_blood-brain_barrier1.00316157
91MP0001765_abnormal_ion_homeostasis0.99368862
92MP0003137_abnormal_impulse_conducting0.98898365
93MP0002735_abnormal_chemical_nociception0.96489340
94MP0005253_abnormal_eye_physiology0.96198783
95MP0005174_abnormal_tail_pigmentation0.95454093
96MP0002752_abnormal_somatic_nervous0.94888041
97MP0001177_atelectasis0.94495292
98MP0000230_abnormal_systemic_arterial0.93664924
99MP0005623_abnormal_meninges_morphology0.93507471
100MP0002184_abnormal_innervation0.92206253
101MP0004019_abnormal_vitamin_homeostasis0.91971658
102MP0004811_abnormal_neuron_physiology0.91048861
103MP0004215_abnormal_myocardial_fiber0.90843811
104MP0002909_abnormal_adrenal_gland0.90758749
105MP0003724_increased_susceptibility_to0.90669444
106MP0000013_abnormal_adipose_tissue0.90507048
107MP0009250_abnormal_appendicular_skeleto0.90010028
108MP0004085_abnormal_heartbeat0.87858345
109MP0000569_abnormal_digit_pigmentation0.86366244
110MP0000026_abnormal_inner_ear0.83899591
111MP0003122_maternal_imprinting0.83350219
112MP0000647_abnormal_sebaceous_gland0.82945494
113MP0010329_abnormal_lipoprotein_level0.82604487
114MP0000462_abnormal_digestive_system0.81837859
115MP0002751_abnormal_autonomic_nervous0.81488101
116MP0003183_abnormal_peptide_metabolism0.80439654
117MP0003011_delayed_dark_adaptation0.79712470
118MP0001879_abnormal_lymphatic_vessel0.79710343
119MP0005671_abnormal_response_to0.79702284
120MP0005377_hearing/vestibular/ear_phenot0.78823681
121MP0003878_abnormal_ear_physiology0.78823681
122MP0006072_abnormal_retinal_apoptosis0.78376877
123MP0001919_abnormal_reproductive_system0.78151987
124MP0005409_darkened_coat_color0.77244714
125MP0005379_endocrine/exocrine_gland_phen0.77090746
126MP0005195_abnormal_posterior_eye0.74806440
127MP0002249_abnormal_larynx_morphology0.74571531
128MP0000639_abnormal_adrenal_gland0.73083340
129MP0005595_abnormal_vascular_smooth0.69931258
130MP0002653_abnormal_ependyma_morphology0.67621129
131MP0002069_abnormal_eating/drinking_beha0.64120708
132MP0000747_muscle_weakness0.63707833
133MP0004134_abnormal_chest_morphology0.63331487
134MP0000631_abnormal_neuroendocrine_gland0.61096819
135MP0008874_decreased_physiological_sensi0.60949048
136MP0000751_myopathy0.60892529
137MP0000579_abnormal_nail_morphology0.60421847
138MP0001943_abnormal_respiration0.57358227
139MP0001346_abnormal_lacrimal_gland0.57270855
140MP0003938_abnormal_ear_development0.57139178
141MP0005332_abnormal_amino_acid0.56714930

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.64427493
2Aplasia involving bones of the upper limbs (HP:0009823)5.30343667
3Aplasia of the phalanges of the hand (HP:0009802)5.30343667
4Aplasia involving bones of the extremities (HP:0009825)5.30343667
5Cerebral inclusion bodies (HP:0100314)4.91935988
6Myokymia (HP:0002411)4.37189923
7Decreased circulating renin level (HP:0003351)4.36251596
8Supranuclear gaze palsy (HP:0000605)4.11636143
9* Megalencephaly (HP:0001355)4.02166861
10Focal motor seizures (HP:0011153)3.80465570
11Peripheral hypomyelination (HP:0007182)3.75294912
12Hemiparesis (HP:0001269)3.67455655
13Abnormality of binocular vision (HP:0011514)3.61596964
14Diplopia (HP:0000651)3.61596964
15Degeneration of the lateral corticospinal tracts (HP:0002314)3.51056640
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.51056640
17Split foot (HP:0001839)3.36201108
18Intention tremor (HP:0002080)3.30634731
19Action tremor (HP:0002345)3.29622770
20Epileptic encephalopathy (HP:0200134)3.17591302
21Abolished electroretinogram (ERG) (HP:0000550)3.17091340
22Aplasia/Hypoplasia of the tibia (HP:0005772)3.13136737
23Dysmetria (HP:0001310)3.11560141
24Short tibia (HP:0005736)3.11516271
25Humeroradial synostosis (HP:0003041)3.05884594
26Synostosis involving the elbow (HP:0003938)3.05884594
27Abnormality of the renal collecting system (HP:0004742)3.03702960
28Congenital, generalized hypertrichosis (HP:0004540)3.02660685
29Abnormality of the proximal phalanges of the hand (HP:0009834)2.94945153
30Ankle clonus (HP:0011448)2.93593256
31Hemiplegia (HP:0002301)2.90530959
32Abnormality of the corticospinal tract (HP:0002492)2.88197264
33Short 4th metacarpal (HP:0010044)2.88036079
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.88036079
35Short femoral neck (HP:0100864)2.84781340
36Pancreatic cysts (HP:0001737)2.84226963
37Congenital stationary night blindness (HP:0007642)2.83303525
38Dysdiadochokinesis (HP:0002075)2.75250074
39Spastic gait (HP:0002064)2.72765026
40Genetic anticipation (HP:0003743)2.72262843
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.71310890
42Nephronophthisis (HP:0000090)2.71023032
43Focal seizures (HP:0007359)2.69889236
44Abnormality of the middle phalanges of the toes (HP:0010183)2.67826533
45Cerebral palsy (HP:0100021)2.67336319
46Abnormality of renin-angiotensin system (HP:0000847)2.67311970
47Hypoplasia of the ulna (HP:0003022)2.66552011
48Alacrima (HP:0000522)2.65306483
49Aplasia/Hypoplasia of the fibula (HP:0006492)2.62355500
50Increased circulating renin level (HP:0000848)2.59630628
51Fibular hypoplasia (HP:0003038)2.56424896
52Methylmalonic aciduria (HP:0012120)2.55723381
53Progressive cerebellar ataxia (HP:0002073)2.54919988
54Persistence of primary teeth (HP:0006335)2.54093582
55Onion bulb formation (HP:0003383)2.53281493
56Abnormal drinking behavior (HP:0030082)2.51840590
57Polydipsia (HP:0001959)2.51840590
58Adactyly (HP:0009776)2.51736467
59Abnormality of the 4th metacarpal (HP:0010012)2.51541788
60Abnormal eating behavior (HP:0100738)2.50271729
61Hypoplastic left heart (HP:0004383)2.47694179
62Pancreatic fibrosis (HP:0100732)2.44058791
63Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.41411614
64Abnormality of the nasal septum (HP:0000419)2.40259030
65Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.39105408
66Retinal dysplasia (HP:0007973)2.37399124
67Postural instability (HP:0002172)2.36417191
68True hermaphroditism (HP:0010459)2.36334866
69Scanning speech (HP:0002168)2.35961115
70Thickened helices (HP:0000391)2.35909707
71Thyroid-stimulating hormone excess (HP:0002925)2.34842730
72Morphological abnormality of the middle ear (HP:0008609)2.34593609
73Asplenia (HP:0001746)2.34258764
74Periauricular skin pits (HP:0100277)2.33996242
75Preauricular pit (HP:0004467)2.33996242
76Synostosis of carpal bones (HP:0005048)2.33296858
77Abnormality of the renal cortex (HP:0011035)2.32727131
78Lower limb muscle weakness (HP:0007340)2.32416127
79Coronal craniosynostosis (HP:0004440)2.31224584
80Pendular nystagmus (HP:0012043)2.30978275
81Termporal pattern (HP:0011008)2.30174665
82Insidious onset (HP:0003587)2.30174665
83Slow saccadic eye movements (HP:0000514)2.28401047
84Anteriorly placed anus (HP:0001545)2.28070476
85Abnormality of the renal medulla (HP:0100957)2.27012956
86Molar tooth sign on MRI (HP:0002419)2.25391478
87Abnormality of midbrain morphology (HP:0002418)2.25391478
88Abnormality of the axillary hair (HP:0100134)2.25348402
89Abnormality of secondary sexual hair (HP:0009888)2.25348402
90Confusion (HP:0001289)2.25337203
91Hematochezia (HP:0002573)2.24592276
92Generalized tonic-clonic seizures (HP:0002069)2.23253977
93Oligodontia (HP:0000677)2.22996039
94Morphological abnormality of the inner ear (HP:0011390)2.22703019
95Aplasia/Hypoplasia of the spleen (HP:0010451)2.22064571
96Congenital sensorineural hearing impairment (HP:0008527)2.21492153
97Hypoplastic pelvis (HP:0008839)2.21488661
98Abnormality of cochlea (HP:0000375)2.21370238
99Abnormal auditory evoked potentials (HP:0006958)2.20760450
100Stenosis of the external auditory canal (HP:0000402)2.20349621
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.20189298
102Fibular aplasia (HP:0002990)2.19936052
103Mesomelia (HP:0003027)2.19853359
104Truncal ataxia (HP:0002078)2.19832626
105Mixed hearing impairment (HP:0000410)2.19758564
106Metabolic alkalosis (HP:0200114)2.18964591
107Abnormality of the phalanges of the 5th finger (HP:0004213)2.17926409
108Alkalosis (HP:0001948)2.15357962
109Goiter (HP:0000853)2.15252869
110Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.13058641
111Stomach cancer (HP:0012126)2.12887354
112IgG deficiency (HP:0004315)2.12034139
113Aplasia/Hypoplasia of the ulna (HP:0006495)2.11550114
114Gaze-evoked nystagmus (HP:0000640)2.08848559
115Febrile seizures (HP:0002373)2.07988720
116Genu varum (HP:0002970)2.07949355
117Type II lissencephaly (HP:0007260)2.05433215
118Patent foramen ovale (HP:0001655)2.05252781
119Decreased central vision (HP:0007663)2.03534252
120Rigidity (HP:0002063)2.03334751
121Decreased lacrimation (HP:0000633)2.03218684
122Hypoplasia of the uterus (HP:0000013)2.02938100
123Keratoconus (HP:0000563)2.02890061
124Increased corneal curvature (HP:0100692)2.02890061
125Paraparesis (HP:0002385)2.01764993
126Aplasia/Hypoplasia of the patella (HP:0006498)2.01307167
127Disproportionate short-trunk short stature (HP:0003521)2.01084858
128Long nose (HP:0003189)2.00638947
129Abnormality of the phalanges of the 2nd finger (HP:0009541)1.99481370
130Anxiety (HP:0000739)1.99002099
131Abnormality of the right ventricle (HP:0001707)1.97827434
132Sensory axonal neuropathy (HP:0003390)1.97312468
133Parakeratosis (HP:0001036)1.96420860
134Cystic liver disease (HP:0006706)1.94963637
135Pheochromocytoma (HP:0002666)1.94559178
136Depression (HP:0000716)1.93185124
137Spastic paraparesis (HP:0002313)1.92789453
138Bronchomalacia (HP:0002780)1.92375102
139Aplasia/hypoplasia of the femur (HP:0005613)1.92013238
140Radial bowing (HP:0002986)1.91687568
141Absent septum pellucidum (HP:0001331)1.91284219
142Sclerocornea (HP:0000647)1.89681342
143Polyphagia (HP:0002591)1.89669616
144Neuronal loss in central nervous system (HP:0002529)1.89247655
145Syncope (HP:0001279)1.89192769
146Abnormality of the dental pulp (HP:0006479)1.88518704
147Visual hallucinations (HP:0002367)1.87565159
148Small hand (HP:0200055)1.86155905
149Back pain (HP:0003418)1.84793631
150Concave nail (HP:0001598)1.84115997
151Hypoplastic heart (HP:0001961)1.84085510
152Short hallux (HP:0010109)1.84047472
153Generalized myoclonic seizures (HP:0002123)1.83911780
154Hyperventilation (HP:0002883)1.83274220
155Bulbous nose (HP:0000414)1.82163762
156Urinary incontinence (HP:0000020)1.80163764
157Dialeptic seizures (HP:0011146)1.79680513
158Clonus (HP:0002169)1.79441334
159Hypokalemic alkalosis (HP:0001949)1.76166554
160Atonic seizures (HP:0010819)1.76036496
161Partial duplication of thumb phalanx (HP:0009944)1.75988598
162Urinary urgency (HP:0000012)1.75153641
163Symphalangism affecting the phalanges of the hand (HP:0009773)1.74827644
164Methylmalonic acidemia (HP:0002912)1.74093103
165Absent/shortened dynein arms (HP:0200106)1.72677894
166Dynein arm defect of respiratory motile cilia (HP:0012255)1.72677894
167Status epilepticus (HP:0002133)1.71554129
168Turricephaly (HP:0000262)1.70803088
169Abnormal ciliary motility (HP:0012262)1.70149093
170Neuroendocrine neoplasm (HP:0100634)1.69752736
171Broad-based gait (HP:0002136)1.69226959
172Spastic tetraparesis (HP:0001285)1.69197917
173Choreoathetosis (HP:0001266)1.67890619
174Taurodontia (HP:0000679)1.67619542
175Abnormality of permanent molar morphology (HP:0011071)1.67619542
176Abnormality of the dental root (HP:0006486)1.67619542
177Aplasia/Hypoplasia of the hallux (HP:0008362)1.67091923

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK17.09188750
2EPHA44.21260657
3FRK3.82167290
4STK393.37320334
5LMTK23.29957374
6PHKG22.98554157
7PHKG12.98554157
8NTRK22.97159447
9TAOK32.96378948
10GRK12.82200445
11TNIK2.70833423
12ADRBK22.67515990
13OXSR12.67121553
14PRKD32.44221980
15BMPR1B1.98761559
16EPHB11.95058112
17PRPF4B1.91574383
18MUSK1.89679636
19FGFR21.87040007
20NTRK31.80915298
21SGK4941.80094332
22SGK2231.80094332
23PAK61.79161160
24NTRK11.75192853
25CDK191.74264287
26CASK1.73609122
27MARK11.73110060
28TXK1.66594017
29PKN11.57062193
30MAPKAPK51.48457433
31PIK3CA1.45146557
32TYRO31.44436447
33FGR1.41323882
34WNK11.37562947
35MAP3K91.35252307
36NEK61.33758763
37ROCK21.33388429
38MAP4K21.32353703
39CDK51.32180295
40UHMK11.31986255
41CAMK2B1.24289137
42ACVR1B1.23728543
43WNK41.22790491
44PNCK1.22475215
45MINK11.20928589
46ZAK1.18638334
47BCR1.12600201
48TIE11.12328289
49MAPK131.10120797
50MET1.07179181
51LIMK11.07081427
52INSRR1.06314132
53RPS6KA21.04480379
54CAMK2G1.02094369
55BUB11.01307791
56PINK10.99593497
57CAMK2D0.98526147
58MAP2K20.98350069
59CAMK2A0.97700359
60SIK10.96231326
61KIT0.93641812
62CSNK1G20.91750114
63CDK150.91428507
64ICK0.91020407
65CDK140.89472132
66NUAK10.87918853
67CDK180.86423084
68MAP3K40.85614511
69PAK30.85455379
70SGK20.84029462
71WNK30.83812813
72BCKDK0.83036688
73PRKCH0.82347635
74EPHA30.82343161
75RPS6KA60.81826630
76PBK0.81417640
77KSR20.81368119
78CDK11A0.80837871
79PRKCG0.79854702
80PRKCE0.77888354
81GRK70.77784819
82MAP3K130.77309536
83GRK60.76487801
84CSNK1A1L0.74546192
85SGK30.73282204
86SIK20.71754017
87CSNK1G30.71710804
88MARK20.71638117
89MAPK150.71019388
90PRKCQ0.70673997
91MAP2K70.68219529
92CAMK1G0.67398844
93PDPK10.66906846
94CAMKK20.66616531
95DYRK1A0.65690766
96DAPK20.65132351
97IRAK20.64522322
98FES0.63862862
99MAPK120.63805389
100CAMKK10.63608977
101DDR20.63468805
102DMPK0.63384557
103IKBKB0.63158963
104ERBB20.62845861
105SYK0.60171571
106BMX0.59812923
107PRKD10.59578838
108STK110.58073488
109ITK0.56657326
110MAP2K10.56312577
111CSNK1G10.55969146
112ROCK10.55732695
113SGK10.55698117
114FYN0.54717544
115IGF1R0.53746676
116PRKCZ0.52871472
117RPS6KL10.52610736
118RPS6KC10.52610736
119MST40.52138930
120ARAF0.51469973
121PRKG10.51236830
122PRKCA0.49795585
123GRK50.48297529
124CLK10.48236180
125PRKACG0.47360261
126TESK20.47222214
127TEC0.46942472
128MAPKAPK30.45878991
129MAPK70.45647487
130STK160.44921477
131AKT30.44542642
132PRKD20.44417416
133PDK10.43784970
134CAMK10.42687499
135DYRK20.41907825
136PLK20.41451981
137ADRBK10.41401056
138RPS6KA30.41058398
139HIPK20.39328252
140CSNK1A10.38866452
141TGFBR10.38638374
142PTK2B0.38570754
143PRKACA0.37380902
144MAPK100.37322074
145MAPK40.37203470
146RPS6KA50.36562262
147NEK20.35830819
148ERBB40.35395874

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.63006082
2Fatty acid biosynthesis_Homo sapiens_hsa000613.00116847
3Steroid biosynthesis_Homo sapiens_hsa001002.59233663
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44726758
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.30965011
6GABAergic synapse_Homo sapiens_hsa047272.28594040
7Nicotine addiction_Homo sapiens_hsa050332.27500145
8Glutamatergic synapse_Homo sapiens_hsa047242.19163157
9Fatty acid elongation_Homo sapiens_hsa000622.14986581
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.06485208
11Phototransduction_Homo sapiens_hsa047441.90473768
12Linoleic acid metabolism_Homo sapiens_hsa005911.87199602
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.83035453
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.77593956
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76564019
16Tryptophan metabolism_Homo sapiens_hsa003801.76305430
17Salivary secretion_Homo sapiens_hsa049701.74046510
18Morphine addiction_Homo sapiens_hsa050321.73535101
19Gastric acid secretion_Homo sapiens_hsa049711.65710509
20Fatty acid metabolism_Homo sapiens_hsa012121.65206393
21Circadian entrainment_Homo sapiens_hsa047131.65110802
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64597504
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61838839
24Ether lipid metabolism_Homo sapiens_hsa005651.57457897
25Oxidative phosphorylation_Homo sapiens_hsa001901.56980189
26Selenocompound metabolism_Homo sapiens_hsa004501.47943857
27Cocaine addiction_Homo sapiens_hsa050301.47093086
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44508868
29Vitamin digestion and absorption_Homo sapiens_hsa049771.43788626
30Synaptic vesicle cycle_Homo sapiens_hsa047211.43565579
31Insulin secretion_Homo sapiens_hsa049111.40421174
32Olfactory transduction_Homo sapiens_hsa047401.34882323
33Vitamin B6 metabolism_Homo sapiens_hsa007501.20583812
34Amphetamine addiction_Homo sapiens_hsa050311.20068256
35Serotonergic synapse_Homo sapiens_hsa047261.18963049
36Long-term potentiation_Homo sapiens_hsa047201.18424829
37Caffeine metabolism_Homo sapiens_hsa002321.18028557
38Butanoate metabolism_Homo sapiens_hsa006501.14961124
39Parkinsons disease_Homo sapiens_hsa050121.14079696
40Long-term depression_Homo sapiens_hsa047301.13970199
41Alzheimers disease_Homo sapiens_hsa050101.13377661
42Axon guidance_Homo sapiens_hsa043601.12927685
43Sulfur metabolism_Homo sapiens_hsa009201.12333981
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09370840
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07704434
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07691329
47Dopaminergic synapse_Homo sapiens_hsa047281.07364940
48Retinol metabolism_Homo sapiens_hsa008301.06334987
49Type II diabetes mellitus_Homo sapiens_hsa049301.04512156
50Protein export_Homo sapiens_hsa030601.04078978
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03879571
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01998857
53Asthma_Homo sapiens_hsa053101.01353107
54Cholinergic synapse_Homo sapiens_hsa047251.00467450
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00048420
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98054055
57Taste transduction_Homo sapiens_hsa047420.97354818
58ABC transporters_Homo sapiens_hsa020100.96643627
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96475700
60Sphingolipid metabolism_Homo sapiens_hsa006000.96394593
61cAMP signaling pathway_Homo sapiens_hsa040240.96245350
62Renin secretion_Homo sapiens_hsa049240.95484054
63Calcium signaling pathway_Homo sapiens_hsa040200.95466265
64Bile secretion_Homo sapiens_hsa049760.92179301
65Pancreatic secretion_Homo sapiens_hsa049720.92038759
66RNA polymerase_Homo sapiens_hsa030200.90641861
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.90196857
68Dorso-ventral axis formation_Homo sapiens_hsa043200.90094857
69Mineral absorption_Homo sapiens_hsa049780.88748633
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88337842
71Chemical carcinogenesis_Homo sapiens_hsa052040.87157423
72Sulfur relay system_Homo sapiens_hsa041220.86093610
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.84862929
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83759706
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83685261
76Fatty acid degradation_Homo sapiens_hsa000710.82426476
77Cardiac muscle contraction_Homo sapiens_hsa042600.81602385
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81313428
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81076347
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.79338132
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78718387
82Fat digestion and absorption_Homo sapiens_hsa049750.78695057
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78093449
84Propanoate metabolism_Homo sapiens_hsa006400.78053483
85Gap junction_Homo sapiens_hsa045400.77832264
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76430917
87PPAR signaling pathway_Homo sapiens_hsa033200.70571214
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70534686
89Melanogenesis_Homo sapiens_hsa049160.70490182
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.69844089
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68579656
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68319432
93Arachidonic acid metabolism_Homo sapiens_hsa005900.67916452
94Peroxisome_Homo sapiens_hsa041460.66898603
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66110324
96Oxytocin signaling pathway_Homo sapiens_hsa049210.64956794
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.62892998
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.62631151
99Arginine and proline metabolism_Homo sapiens_hsa003300.60927177
100Thyroid hormone synthesis_Homo sapiens_hsa049180.60119884
101Primary immunodeficiency_Homo sapiens_hsa053400.59629271
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59248349
103Graft-versus-host disease_Homo sapiens_hsa053320.59159520
104ErbB signaling pathway_Homo sapiens_hsa040120.58824662
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58452565
106Renal cell carcinoma_Homo sapiens_hsa052110.58205647
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57778114
108Huntingtons disease_Homo sapiens_hsa050160.57586165
109Type I diabetes mellitus_Homo sapiens_hsa049400.56714962
110Circadian rhythm_Homo sapiens_hsa047100.56630847
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55804558
112GnRH signaling pathway_Homo sapiens_hsa049120.54501211
113Collecting duct acid secretion_Homo sapiens_hsa049660.53465579
114Hedgehog signaling pathway_Homo sapiens_hsa043400.52184403
115Regulation of autophagy_Homo sapiens_hsa041400.51592190
116Autoimmune thyroid disease_Homo sapiens_hsa053200.51293939
117RNA degradation_Homo sapiens_hsa030180.50961377
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50170429
119MAPK signaling pathway_Homo sapiens_hsa040100.49981334
120Allograft rejection_Homo sapiens_hsa053300.49705010
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49679651
122Ras signaling pathway_Homo sapiens_hsa040140.49343851
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48856421
124beta-Alanine metabolism_Homo sapiens_hsa004100.46990237
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46713288
126Lysosome_Homo sapiens_hsa041420.44983093
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44627436
128Endocytosis_Homo sapiens_hsa041440.43857451
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43647097
130Choline metabolism in cancer_Homo sapiens_hsa052310.42998822
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42907269
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42567895
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41618774
134Estrogen signaling pathway_Homo sapiens_hsa049150.41575342
135Glycerolipid metabolism_Homo sapiens_hsa005610.40989111
136Rheumatoid arthritis_Homo sapiens_hsa053230.40753595
137Dilated cardiomyopathy_Homo sapiens_hsa054140.39566887
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39463829
139Tight junction_Homo sapiens_hsa045300.38554533
140Ovarian steroidogenesis_Homo sapiens_hsa049130.37979336
141Basal cell carcinoma_Homo sapiens_hsa052170.36583553
142Vibrio cholerae infection_Homo sapiens_hsa051100.35701214
143Rap1 signaling pathway_Homo sapiens_hsa040150.34861894
144Histidine metabolism_Homo sapiens_hsa003400.32658988

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