HENMT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)9.54452858
2male meiosis (GO:0007140)8.92883290
3multicellular organism reproduction (GO:0032504)8.66686416
4regulation of female gonad development (GO:2000194)7.09401764
5reproduction (GO:0000003)6.95680416
6cilium or flagellum-dependent cell motility (GO:0001539)6.93232370
7synaptonemal complex assembly (GO:0007130)6.92552510
8fusion of sperm to egg plasma membrane (GO:0007342)6.91384059
9synaptonemal complex organization (GO:0070193)6.89087931
10synapsis (GO:0007129)6.81070366
11sperm-egg recognition (GO:0035036)6.60572121
12binding of sperm to zona pellucida (GO:0007339)6.32569497
13meiotic cell cycle (GO:0051321)6.23924742
14base-excision repair, AP site formation (GO:0006285)6.22289876
15pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.19336281
16protein K6-linked ubiquitination (GO:0085020)5.84383273
17cell-cell recognition (GO:0009988)5.84307409
18microtubule severing (GO:0051013)5.69549467
19axonemal dynein complex assembly (GO:0070286)5.66479179
20regulation of meiosis I (GO:0060631)5.65534554
21single fertilization (GO:0007338)5.56801942
22female gamete generation (GO:0007292)5.55103288
23sperm motility (GO:0030317)5.51001643
24meiotic nuclear division (GO:0007126)5.47952000
25regulation of meiosis (GO:0040020)5.45856951
26pyrimidine nucleotide catabolic process (GO:0006244)5.39431237
27fertilization (GO:0009566)5.35606080
28spermatid development (GO:0007286)5.31477779
29plasma membrane fusion (GO:0045026)5.19352396
30motile cilium assembly (GO:0044458)5.11877697
31regulation of acrosome reaction (GO:0060046)5.04778504
32* gene silencing by RNA (GO:0031047)5.03086799
33acrosome assembly (GO:0001675)4.89656486
34negative regulation of meiosis (GO:0045835)4.87744675
35cell wall macromolecule metabolic process (GO:0044036)4.86584772
36cell wall macromolecule catabolic process (GO:0016998)4.86584772
37male meiosis I (GO:0007141)4.84877972
38epithelial cilium movement (GO:0003351)4.84685530
39chromosome organization involved in meiosis (GO:0070192)4.80645091
40acrosome reaction (GO:0007340)4.73238673
41DNA methylation (GO:0006306)4.66900891
42DNA alkylation (GO:0006305)4.66900891
43regulation of histone H3-K9 methylation (GO:0051570)4.63579693
44regulation of DNA methylation (GO:0044030)4.58699194
45gamete generation (GO:0007276)4.45830844
46spermatogenesis (GO:0007283)4.43718526
47male gamete generation (GO:0048232)4.42680669
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.40097987
49oocyte maturation (GO:0001556)4.37824561
50histone H2A ubiquitination (GO:0033522)4.37083333
51regulation of meiotic cell cycle (GO:0051445)4.31347815
52gonadal mesoderm development (GO:0007506)4.25609805
53oocyte development (GO:0048599)4.25202118
54cilium movement (GO:0003341)4.17647588
55positive regulation of histone H3-K4 methylation (GO:0051571)4.12728411
56oogenesis (GO:0048477)4.11230734
57regulation of cilium movement (GO:0003352)4.10337847
58germ cell development (GO:0007281)4.10045899
59mitotic chromosome condensation (GO:0007076)4.08311572
60microtubule depolymerization (GO:0007019)4.08305046
61meiotic cell cycle process (GO:1903046)4.07504078
62positive regulation of meiosis (GO:0045836)4.05901750
63citrulline biosynthetic process (GO:0019240)4.02144398
64negative regulation of smooth muscle cell differentiation (GO:0051151)4.00622575
65meiosis I (GO:0007127)4.00343305
66negative regulation of meiotic cell cycle (GO:0051447)3.97421093
67pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.97087802
68histone H2A monoubiquitination (GO:0035518)3.86879807
69positive regulation of meiotic cell cycle (GO:0051446)3.84468060
70cellular process involved in reproduction in multicellular organism (GO:0022412)3.83185341
71proteasome assembly (GO:0043248)3.78229906
72mitotic sister chromatid cohesion (GO:0007064)3.73361847
73resolution of meiotic recombination intermediates (GO:0000712)3.72003374
74CENP-A containing nucleosome assembly (GO:0034080)3.71212945
75sister chromatid cohesion (GO:0007062)3.65060913
76mitotic metaphase plate congression (GO:0007080)3.61299368
77histone exchange (GO:0043486)3.58961255
78protein polyglutamylation (GO:0018095)3.58757588
79DNA modification (GO:0006304)3.58711918
80negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.56368247
81monoubiquitinated protein deubiquitination (GO:0035520)3.55189596
82negative regulation of inclusion body assembly (GO:0090084)3.51805076
83attachment of spindle microtubules to kinetochore (GO:0008608)3.51252396
84chromatin remodeling at centromere (GO:0031055)3.49318245
85regulation of exit from mitosis (GO:0007096)3.46347415
86multicellular organismal reproductive process (GO:0048609)3.44417806
87DNA deamination (GO:0045006)3.41382480
88DNA methylation or demethylation (GO:0044728)3.41033207
89notochord development (GO:0030903)3.39888642
90regulation of RIG-I signaling pathway (GO:0039535)3.38183892
91telomere maintenance via semi-conservative replication (GO:0032201)3.36819213
92* gene silencing (GO:0016458)3.35749172
93protein deneddylation (GO:0000338)3.35327984
94negative regulation of organelle assembly (GO:1902116)3.30796194
95phosphatidylglycerol biosynthetic process (GO:0006655)3.29745959
96regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.23695709
97regulation of histone H3-K27 methylation (GO:0061085)3.10249351
98chaperone-mediated protein transport (GO:0072321)3.09347308
99DNA damage induced protein phosphorylation (GO:0006975)3.08539721
100sperm capacitation (GO:0048240)3.07852694
101endothelium development (GO:0003158)3.05228807
102ribosomal small subunit assembly (GO:0000028)3.04778845
103deoxyribose phosphate catabolic process (GO:0046386)3.03535857
104reciprocal DNA recombination (GO:0035825)3.02099998
105reciprocal meiotic recombination (GO:0007131)3.02099998
106somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01763243
107somatic hypermutation of immunoglobulin genes (GO:0016446)3.01763243
108protein localization to chromosome, centromeric region (GO:0071459)3.00513645
109centriole replication (GO:0007099)3.00453807
110organelle membrane fusion (GO:0090174)3.00206976
111protein autoubiquitination (GO:0051865)2.99573837
112telomere maintenance via recombination (GO:0000722)2.99495123
113retinal cone cell development (GO:0046549)2.94835148
114deoxyribonucleotide catabolic process (GO:0009264)2.93994487
115positive regulation of B cell differentiation (GO:0045579)2.93067875
116response to pheromone (GO:0019236)2.92098691
117chromosome condensation (GO:0030261)2.90491569
118microtubule polymerization or depolymerization (GO:0031109)2.89993397
119regulation of sister chromatid cohesion (GO:0007063)2.89622381
120DNA strand elongation involved in DNA replication (GO:0006271)2.89439762
121meiotic chromosome segregation (GO:0045132)2.88920470
122protein localization to chromosome (GO:0034502)2.86838939
123DNA strand elongation (GO:0022616)2.84281487
124positive regulation of histone methylation (GO:0031062)2.84253143
125nucleotide-excision repair, DNA gap filling (GO:0006297)2.78599711
126DNA replication-dependent nucleosome assembly (GO:0006335)2.77497839
127DNA replication-dependent nucleosome organization (GO:0034723)2.77497839
128DNA replication-independent nucleosome organization (GO:0034724)2.77231770
129DNA replication-independent nucleosome assembly (GO:0006336)2.77231770
130mitotic recombination (GO:0006312)2.76062452
131regulation of double-strand break repair via homologous recombination (GO:0010569)2.74369797
132DNA synthesis involved in DNA repair (GO:0000731)2.73886757
133positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.70868261
134positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.70868261
135positive regulation of mitotic sister chromatid separation (GO:1901970)2.70868261
136purine deoxyribonucleotide catabolic process (GO:0009155)2.70857453
137regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.70457849
138regulation of mitotic spindle checkpoint (GO:1903504)2.70457849
139deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.69399683
140translesion synthesis (GO:0019985)2.69037217
141DNA catabolic process, exonucleolytic (GO:0000738)2.68868604
142regulation of histone H3-K4 methylation (GO:0051569)2.67978708
143positive regulation of translational initiation (GO:0045948)2.66348318
144chaperone mediated protein folding requiring cofactor (GO:0051085)2.65571464
145mismatch repair (GO:0006298)2.63236731
146autophagic vacuole fusion (GO:0000046)2.62127196
147RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.57875651
148anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.57456352
149deoxyribose phosphate metabolic process (GO:0019692)2.57271056
150telomere maintenance via telomere lengthening (GO:0010833)2.54616686
151positive regulation of chromosome segregation (GO:0051984)2.54222807
1522-deoxyribonucleotide metabolic process (GO:0009394)2.52768109
153base-excision repair (GO:0006284)2.50628091
154protein localization to kinetochore (GO:0034501)2.50271837
155centriole assembly (GO:0098534)2.50216038
156negative regulation of histone methylation (GO:0031061)2.50097664
157* piRNA metabolic process (GO:0034587)13.2114052

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.77192204
2E2F7_22180533_ChIP-Seq_HELA_Human5.67925508
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.37210351
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67548564
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.32852859
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.18283565
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96393123
8KAP1_22055183_ChIP-Seq_ESCs_Mouse2.94410264
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.90147787
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.84193312
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.79103660
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.78317263
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.75750259
14VDR_23849224_ChIP-Seq_CD4+_Human2.62384681
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.53695975
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.51212816
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.48581265
18FOXP3_21729870_ChIP-Seq_TREG_Human2.48201696
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.44361845
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43280675
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.42133965
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.39718069
23EZH2_22144423_ChIP-Seq_EOC_Human2.34432963
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28436381
25GATA1_26923725_Chip-Seq_HPCs_Mouse2.24103554
26VDR_22108803_ChIP-Seq_LS180_Human2.21131892
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.15606277
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.15606277
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.15606277
30MYC_18555785_ChIP-Seq_MESCs_Mouse2.14467386
31RNF2_27304074_Chip-Seq_NSC_Mouse2.12080233
32CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08988268
33ELK4_26923725_Chip-Seq_MESODERM_Mouse2.04145925
34MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.03486433
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02736249
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99427343
37CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.96683462
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96287535
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.96176958
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.93360555
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88872894
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86927473
43RUNX1_26923725_Chip-Seq_HPCs_Mouse1.86667443
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84709202
45GATA3_21867929_ChIP-Seq_TH1_Mouse1.82517538
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.79850908
47STAT1_17558387_ChIP-Seq_HELA_Human1.79602715
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75224537
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.74742566
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69299472
51MYB_26560356_Chip-Seq_TH2_Human1.68688541
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68395040
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68269353
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66345691
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65205262
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64772830
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60161874
58ZNF274_21170338_ChIP-Seq_K562_Hela1.59085387
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.58322502
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56671385
61ELK1_19687146_ChIP-ChIP_HELA_Human1.55951168
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53737848
63DCP1A_22483619_ChIP-Seq_HELA_Human1.51513470
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.49437319
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48809022
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47290099
67IGF1R_20145208_ChIP-Seq_DFB_Human1.46320977
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44295674
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.41093866
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40496640
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.40458923
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39298596
73GABP_19822575_ChIP-Seq_HepG2_Human1.38997755
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38659245
75IRF1_19129219_ChIP-ChIP_H3396_Human1.38509431
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.38134990
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37445859
78AR_21909140_ChIP-Seq_LNCAP_Human1.36899495
79FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36562126
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33685219
81TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.32939204
82SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.31882606
83MYC_18940864_ChIP-ChIP_HL60_Human1.31107894
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30867857
85SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30584726
86SPI1_23547873_ChIP-Seq_NB4_Human1.30233611
87KDM2B_26808549_Chip-Seq_REH_Human1.30066985
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30020531
89FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29461171
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28341708
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.27913658
92NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27480463
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27107218
94KLF4_18555785_Chip-Seq_ESCs_Mouse1.27070463
95NFYA_21822215_ChIP-Seq_K562_Human1.26526316
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26494363
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25487710
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24182179
99CTCF_18555785_Chip-Seq_ESCs_Mouse1.23712482
100ESRRB_18555785_Chip-Seq_ESCs_Mouse1.23696323
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.23484986
102CDX2_22108803_ChIP-Seq_LS180_Human1.21955422
103EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21025465
104CIITA_25753668_ChIP-Seq_RAJI_Human1.19306244
105CBX2_22325352_ChIP-Seq_293T-Rex_Human1.19244592
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19180810
107ETV1_20927104_ChIP-Seq_GIST48_Human1.19082972
108LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18697855
109GF1B_26923725_Chip-Seq_HPCs_Mouse1.17388780
110POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17048871
111CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16459606
112TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16160337
113MYB_26560356_Chip-Seq_TH1_Human1.15799433
114TTF2_22483619_ChIP-Seq_HELA_Human1.15085175
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15012304
116ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14378839
117NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13840271
118TAL1_26923725_Chip-Seq_HPCs_Mouse1.13720936
119TP53_22573176_ChIP-Seq_HFKS_Human1.13215445
120LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13203729
121ZFX_18555785_Chip-Seq_ESCs_Mouse1.13013675
122CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12995550
123IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12681455
124HNFA_21074721_ChIP-Seq_CACO-2_Human1.12007630
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.11449290
126PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10723483
127P300_18555785_Chip-Seq_ESCs_Mouse1.10647590
128RBPJ_21746931_ChIP-Seq_IB4_Human1.09932347
129GATA3_27048872_Chip-Seq_THYMUS_Human1.09624607
130P53_22387025_ChIP-Seq_ESCs_Mouse1.09004098
131GATA3_21867929_ChIP-Seq_CD8_Mouse1.08928091
132NFYB_21822215_ChIP-Seq_K562_Human1.08746106
133SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08048992
134GATA3_26560356_Chip-Seq_TH2_Human1.08047683
135E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07885012
136EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07607224
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07563960
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07563960
139FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07256845
140RUNX_20019798_ChIP-Seq_JUKART_Human1.06799194
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06427995
142E2F1_21310950_ChIP-Seq_MCF-7_Human1.06403677
143CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06080611
144RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06073051
145SOX2_18555785_Chip-Seq_ESCs_Mouse1.06036447
146NMYC_18555785_Chip-Seq_ESCs_Mouse1.05963803
147NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.05774722
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05483412
149SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05073915
150E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04775764
151GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04566260
152STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03873401
153PHF8_20622853_ChIP-Seq_HELA_Human1.03430836
154SCL_19346495_ChIP-Seq_HPC-7_Human1.01668862
155ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01355731
156TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01205928
157TBL1_22424771_ChIP-Seq_293T_Human1.00614177
158BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00412204
159KDM5A_27292631_Chip-Seq_BREAST_Human1.00041698
160GF1_26923725_Chip-Seq_HPCs_Mouse0.99927131
161AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99390196
162RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99303063
163PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99263031
164WDR5_24793694_ChIP-Seq_LNCAP_Human0.99131633
165ESET_19884257_ChIP-Seq_ESCs_Mouse0.98330451
166ERG_20517297_ChIP-Seq_VCAP_Human0.98187336
167MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97827307
168GATA6_21074721_ChIP-Seq_CACO-2_Human0.97572961
169NANOG_20526341_ChIP-Seq_ESCs_Human0.97286482
170CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97194498
171FLI1_21867929_ChIP-Seq_TH2_Mouse0.96642284
172SPI1_26923725_Chip-Seq_HPCs_Mouse0.96624094
173HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96543769
174HTT_18923047_ChIP-ChIP_STHdh_Human0.96276897
175E2F1_18555785_Chip-Seq_ESCs_Mouse0.95940465
176CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95464890
177PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95095159
178FOXA1_25329375_ChIP-Seq_VCAP_Human0.94410049
179FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94410049
180MYC_27129775_Chip-Seq_CORNEA_Mouse0.93119699
181ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93021634
182GATA3_26560356_Chip-Seq_TH1_Human0.92927732
183FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91728616
184TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90100142
185KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87198538
186EWS_26573619_Chip-Seq_HEK293_Human0.87173669
187AR_20517297_ChIP-Seq_VCAP_Human0.83737246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.42133272
2MP0005410_abnormal_fertilization6.31855734
3MP0003646_muscle_fatigue5.72819689
4MP0001929_abnormal_gametogenesis4.84126275
5MP0003718_maternal_effect4.48796605
6MP0002210_abnormal_sex_determination3.87618534
7MP0002653_abnormal_ependyma_morphology3.73816980
8MP0003698_abnormal_male_reproductive3.56957374
9MP0000653_abnormal_sex_gland3.39338512
10MP0010094_abnormal_chromosome_stability3.06833540
11MP0001145_abnormal_male_reproductive2.98037802
12MP0010386_abnormal_urinary_bladder2.83821834
13MP0002161_abnormal_fertility/fecundity2.80308189
14MP0001119_abnormal_female_reproductive2.67519134
15MP0002102_abnormal_ear_morphology2.52564596
16MP0003699_abnormal_female_reproductive2.51080556
17MP0006292_abnormal_olfactory_placode2.47943444
18MP0005451_abnormal_body_composition2.47935858
19MP0008260_abnormal_autophagy2.37106291
20MP0003693_abnormal_embryo_hatching2.32070900
21MP0003183_abnormal_peptide_metabolism2.25106758
22MP0005075_abnormal_melanosome_morpholog2.15207519
23MP0005646_abnormal_pituitary_gland2.12312100
24MP0003111_abnormal_nucleus_morphology2.11887700
25MP0002396_abnormal_hematopoietic_system2.06443625
26MP0001835_abnormal_antigen_presentation1.94353450
27MP0005395_other_phenotype1.92400811
28MP0005671_abnormal_response_to1.91197008
29MP0003077_abnormal_cell_cycle1.83404911
30MP0002138_abnormal_hepatobiliary_system1.72225746
31MP0004957_abnormal_blastocyst_morpholog1.70410743
32MP0002638_abnormal_pupillary_reflex1.61955528
33MP0003787_abnormal_imprinting1.60765572
34MP0004147_increased_porphyrin_level1.57654879
35MP0009333_abnormal_splenocyte_physiolog1.57558396
36MP0008058_abnormal_DNA_repair1.55488940
37MP0003806_abnormal_nucleotide_metabolis1.54495008
38MP0002148_abnormal_hypersensitivity_rea1.54138977
39MP0002295_abnormal_pulmonary_circulatio1.52627223
40MP0000579_abnormal_nail_morphology1.51049990
41MP0002398_abnormal_bone_marrow1.51032790
42MP0003315_abnormal_perineum_morphology1.51030044
43MP0010307_abnormal_tumor_latency1.50838754
44MP0008789_abnormal_olfactory_epithelium1.46322386
45MP0001800_abnormal_humoral_immune1.42775289
46MP0000703_abnormal_thymus_morphology1.40677073
47MP0005174_abnormal_tail_pigmentation1.36874468
48MP0005000_abnormal_immune_tolerance1.36662031
49MP0002420_abnormal_adaptive_immunity1.35214828
50MP0005464_abnormal_platelet_physiology1.34028234
51MP0002160_abnormal_reproductive_system1.33037843
52MP0001529_abnormal_vocalization1.32494352
53MP0001819_abnormal_immune_cell1.30647401
54MP0000689_abnormal_spleen_morphology1.28928468
55MP0008932_abnormal_embryonic_tissue1.25954162
56MP0002723_abnormal_immune_serum1.24161508
57MP0002722_abnormal_immune_system1.24133366
58MP0005389_reproductive_system_phenotype1.21046813
59MP0000716_abnormal_immune_system1.18170101
60MP0002249_abnormal_larynx_morphology1.17295714
61MP0006036_abnormal_mitochondrial_physio1.16579016
62MP0005310_abnormal_salivary_gland1.16400955
63MP0008007_abnormal_cellular_replicative1.12110976
64MP0002452_abnormal_antigen_presenting1.11079584
65MP0003186_abnormal_redox_activity1.09045547
66MP0002006_tumorigenesis1.07345542
67MP0008995_early_reproductive_senescence1.07234629
68MP0002282_abnormal_trachea_morphology1.07181141
69MP0010368_abnormal_lymphatic_system1.06907885
70MP0002139_abnormal_hepatobiliary_system1.03581215
71MP0002429_abnormal_blood_cell1.02782629
72MP0009785_altered_susceptibility_to1.01315988
73MP0005187_abnormal_penis_morphology0.99996554
74MP0001905_abnormal_dopamine_level0.97138828
75MP0003950_abnormal_plasma_membrane0.96395793
76MP0001545_abnormal_hematopoietic_system0.91604484
77MP0005397_hematopoietic_system_phenotyp0.91604484
78MP0005257_abnormal_intraocular_pressure0.91363586
79MP0005025_abnormal_response_to0.91069994
80MP0003786_premature_aging0.90292995
81MP0003436_decreased_susceptibility_to0.87000312
82MP0010155_abnormal_intestine_physiology0.86365986
83MP0005394_taste/olfaction_phenotype0.86285129
84MP0005499_abnormal_olfactory_system0.86285129
85MP0006035_abnormal_mitochondrial_morpho0.85406964
86MP0003763_abnormal_thymus_physiology0.83957923
87MP0001986_abnormal_taste_sensitivity0.83720647
88MP0002419_abnormal_innate_immunity0.83417511
89MP0006072_abnormal_retinal_apoptosis0.83228335
90MP0009379_abnormal_foot_pigmentation0.82572774
91MP0009697_abnormal_copulation0.82349647
92MP0001873_stomach_inflammation0.80858650
93MP0003121_genomic_imprinting0.80752536
94MP0002166_altered_tumor_susceptibility0.77207209
95MP0002085_abnormal_embryonic_tissue0.76329402
96MP0002163_abnormal_gland_morphology0.75749980
97MP0001984_abnormal_olfaction0.75095298
98MP0001730_embryonic_growth_arrest0.74811076
99MP0001790_abnormal_immune_system0.73847706
100MP0005387_immune_system_phenotype0.73847706
101MP0004859_abnormal_synaptic_plasticity0.73051782
102MP0002932_abnormal_joint_morphology0.72998410
103MP0001919_abnormal_reproductive_system0.72870210
104MP0003656_abnormal_erythrocyte_physiolo0.72803762
105MP0000015_abnormal_ear_pigmentation0.72406934
106MP0002405_respiratory_system_inflammati0.70443914
107MP0001915_intracranial_hemorrhage0.69962477
108MP0002132_abnormal_respiratory_system0.69620249
109MP0004142_abnormal_muscle_tone0.69588813
110MP0003937_abnormal_limbs/digits/tail_de0.69368610
111MP0003890_abnormal_embryonic-extraembry0.69301110
112MP0003252_abnormal_bile_duct0.68586053
113MP0002796_impaired_skin_barrier0.68252751
114MP0000350_abnormal_cell_proliferation0.68208059
115MP0001764_abnormal_homeostasis0.66932144
116MP0000372_irregular_coat_pigmentation0.66399018
117MP0008057_abnormal_DNA_replication0.66276570
118MP0005645_abnormal_hypothalamus_physiol0.66175297
119MP0003866_abnormal_defecation0.65787511
120MP0003724_increased_susceptibility_to0.64953744
121MP0000538_abnormal_urinary_bladder0.64808160
122MP0000465_gastrointestinal_hemorrhage0.64465998
123MP0002019_abnormal_tumor_incidence0.64255869
124MP0001346_abnormal_lacrimal_gland0.63597500
125MP0003123_paternal_imprinting0.62785343
126MP0005319_abnormal_enzyme/_coenzyme0.61984621
127MP0000613_abnormal_salivary_gland0.61702633
128MP0000631_abnormal_neuroendocrine_gland0.61676899
129MP0000427_abnormal_hair_cycle0.59892140
130MP0005647_abnormal_sex_gland0.59735513
131MP0000639_abnormal_adrenal_gland0.55244146
132MP0003861_abnormal_nervous_system0.54830873
133MP0002084_abnormal_developmental_patter0.53893370
134MP0004510_myositis0.52649216
135MP0001697_abnormal_embryo_size0.50651072
136MP0004185_abnormal_adipocyte_glucose0.49079587
137MP0001502_abnormal_circadian_rhythm0.48456539
138MP0002177_abnormal_outer_ear0.48453054
139MP0005380_embryogenesis_phenotype0.47640543
140MP0001672_abnormal_embryogenesis/_devel0.47640543
141MP0002234_abnormal_pharynx_morphology0.47587938
142MP0005621_abnormal_cell_physiology0.42425931
143MP0000313_abnormal_cell_death0.41853815
144MP0002116_abnormal_craniofacial_bone0.41710501
145MP0002332_abnormal_exercise_endurance0.39757448
146MP0004782_abnormal_surfactant_physiolog0.38810031
147MP0000490_abnormal_crypts_of0.38369869
148MP0002269_muscular_atrophy0.38359397
149MP0003011_delayed_dark_adaptation0.37124148
150MP0006276_abnormal_autonomic_nervous0.35632259
151MP0002233_abnormal_nose_morphology0.34799331
152MP0003942_abnormal_urinary_system0.33581998
153MP0000685_abnormal_immune_system0.33521980
154MP0004808_abnormal_hematopoietic_stem0.33091224
155MP0002109_abnormal_limb_morphology0.33079567
156MP0000358_abnormal_cell_content/0.32580358
157MP0005623_abnormal_meninges_morphology0.32558799
158MP0005384_cellular_phenotype0.32530713
159MP0004233_abnormal_muscle_weight0.30108329
160MP0005197_abnormal_uvea_morphology0.30097005

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)7.89928160
2Absent/shortened dynein arms (HP:0200106)7.89928160
3Infertility (HP:0000789)7.83955674
4Male infertility (HP:0003251)7.28148067
5Abnormal respiratory motile cilium physiology (HP:0012261)6.76603507
6Rhinitis (HP:0012384)5.72926235
7Abnormal respiratory epithelium morphology (HP:0012253)5.59752185
8Abnormal respiratory motile cilium morphology (HP:0005938)5.59752185
9Chronic bronchitis (HP:0004469)5.41110018
10Abnormal ciliary motility (HP:0012262)4.91001712
11Bronchiectasis (HP:0002110)4.69327731
12Premature ovarian failure (HP:0008209)4.65061957
13Nasal polyposis (HP:0100582)3.96420107
14Cortical dysplasia (HP:0002539)3.82620870
15Abnormal spermatogenesis (HP:0008669)3.79524745
16Nephronophthisis (HP:0000090)3.59970578
17Atelectasis (HP:0100750)3.24482113
18Stomatitis (HP:0010280)3.20716609
19Bronchitis (HP:0012387)3.10049715
20Panhypogammaglobulinemia (HP:0003139)3.09056412
21Type 2 muscle fiber atrophy (HP:0003554)3.06050900
22Abnormality of the nasal mucosa (HP:0000433)3.04072648
23Gonadotropin excess (HP:0000837)3.03412628
24Azoospermia (HP:0000027)3.00089352
25Muscle fiber atrophy (HP:0100295)2.98243322
26Abnormality of the preputium (HP:0100587)2.96936878
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.92943199
28Volvulus (HP:0002580)2.92471027
29B lymphocytopenia (HP:0010976)2.89560999
30Abnormality of B cell number (HP:0010975)2.83836148
31Abnormality of the renal medulla (HP:0100957)2.82201522
32Abnormality of chromosome stability (HP:0003220)2.77376879
33Combined immunodeficiency (HP:0005387)2.76506866
34Pulmonary fibrosis (HP:0002206)2.66020792
35IgG deficiency (HP:0004315)2.61433817
36Overlapping toe (HP:0001845)2.60954661
37Short tibia (HP:0005736)2.58319664
38Meckel diverticulum (HP:0002245)2.57949936
39Chromsome breakage (HP:0040012)2.57361404
40Secondary amenorrhea (HP:0000869)2.56842282
41Impulsivity (HP:0100710)2.56406103
42Severe combined immunodeficiency (HP:0004430)2.51742260
43Osteomalacia (HP:0002749)2.50793524
44Papillary thyroid carcinoma (HP:0002895)2.48438028
45Supernumerary spleens (HP:0009799)2.48351010
46Aplasia/Hypoplasia of the fovea (HP:0008060)2.45317196
47Hypoplasia of the fovea (HP:0007750)2.45317196
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.44665338
49Abnormality of the ileum (HP:0001549)2.44010513
50T lymphocytopenia (HP:0005403)2.43854873
51Abnormality of DNA repair (HP:0003254)2.40239298
52Elevated erythrocyte sedimentation rate (HP:0003565)2.38775910
53Clubbing of toes (HP:0100760)2.37102429
54Abnormality of the prostate (HP:0008775)2.36501249
55Abnormality of the fovea (HP:0000493)2.35881689
56IgM deficiency (HP:0002850)2.33434873
57Anosmia (HP:0000458)2.30031903
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.28571291
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.28571291
60Microvesicular hepatic steatosis (HP:0001414)2.27556961
61Tubular atrophy (HP:0000092)2.24850452
62Flat capital femoral epiphysis (HP:0003370)2.23369127
63Agammaglobulinemia (HP:0004432)2.20366089
64Aplasia/Hypoplasia of the tibia (HP:0005772)2.19967914
65Abnormality of T cell number (HP:0011839)2.19485826
66Posterior subcapsular cataract (HP:0007787)2.19388305
67Primary amenorrhea (HP:0000786)2.19306177
68Hypergonadotropic hypogonadism (HP:0000815)2.19190972
69Median cleft lip (HP:0000161)2.18791254
70Shawl scrotum (HP:0000049)2.18488616
71Recurrent otitis media (HP:0000403)2.18408874
72Increased IgM level (HP:0003496)2.18200300
73Absent thumb (HP:0009777)2.17492520
74Breast aplasia (HP:0100783)2.17078156
75Abnormality of T cells (HP:0002843)2.16439172
76Medial flaring of the eyebrow (HP:0010747)2.15170493
77Type I transferrin isoform profile (HP:0003642)2.14934614
78Amyotrophic lateral sclerosis (HP:0007354)2.12619838
79Pancytopenia (HP:0001876)2.10957752
80Aplasia/Hypoplasia of the macula (HP:0008059)2.10539045
81Lip pit (HP:0100267)2.09039617
82Myelodysplasia (HP:0002863)2.09023769
83Aplasia/Hypoplasia of the breasts (HP:0010311)2.08698057
84Autoimmune hemolytic anemia (HP:0001890)2.07605075
85Reduced antithrombin III activity (HP:0001976)2.07553688
86Molar tooth sign on MRI (HP:0002419)2.07136583
87Abnormality of midbrain morphology (HP:0002418)2.07136583
883-Methylglutaconic aciduria (HP:0003535)2.06552217
89Dicarboxylic aciduria (HP:0003215)2.05914171
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05914171
91Aplasia/Hypoplasia affecting the retina (HP:0008061)2.04878101
92Abnormality of the phalanges of the hallux (HP:0010057)2.03541561
93Abnormality of the labia minora (HP:0012880)2.03149111
94Breast hypoplasia (HP:0003187)2.03123096
95Aplasia/Hypoplasia involving the musculature (HP:0001460)2.02098785
96Agnosia (HP:0010524)2.00645047
97Acute lymphatic leukemia (HP:0006721)2.00213399
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.2061204
99Encephalitis (HP:0002383)1.99251864
100Oligodactyly (hands) (HP:0001180)1.97407222
101Prostate neoplasm (HP:0100787)1.97292896
102Generalized aminoaciduria (HP:0002909)1.95749747
103Facial hemangioma (HP:0000329)1.95052740
104Abnormality of lateral ventricle (HP:0030047)1.93666501
105Attenuation of retinal blood vessels (HP:0007843)1.93449936
106Sloping forehead (HP:0000340)1.92941158
107Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92217051
108Progressive microcephaly (HP:0000253)1.91700039
109Abnormality of the renal collecting system (HP:0004742)1.90436138
110Reticulocytopenia (HP:0001896)1.89174279
111Patellar aplasia (HP:0006443)1.88925329
112Hypokinesia (HP:0002375)1.88797255
113Abnormal protein glycosylation (HP:0012346)1.88362629
114Abnormal glycosylation (HP:0012345)1.88362629
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88362629
116Abnormal protein N-linked glycosylation (HP:0012347)1.88362629
117Nonprogressive disorder (HP:0003680)1.88120832
118Scotoma (HP:0000575)1.84499685
119Recurrent fungal infections (HP:0002841)1.82992801
120Abnormality of the duodenum (HP:0002246)1.81958143
121Abnormal biliary tract physiology (HP:0012439)1.81714629
122Bile duct proliferation (HP:0001408)1.81714629
123Hypogonadotrophic hypogonadism (HP:0000044)1.81696457
124Recurrent sinusitis (HP:0011108)1.81052168
125Birth length less than 3rd percentile (HP:0003561)1.80673096
126Granulocytopenia (HP:0001913)1.80257206
127Abnormality of the carotid arteries (HP:0005344)1.79668991
128Abnormality of T cell physiology (HP:0011840)1.78550666
129Hepatic necrosis (HP:0002605)1.77055620
130Increased CSF lactate (HP:0002490)1.76373316
131Nephroblastoma (Wilms tumor) (HP:0002667)1.76361175
132Pancreatic cysts (HP:0001737)1.76243847
133Cleft eyelid (HP:0000625)1.76080504
134Abnormality of eosinophils (HP:0001879)1.75698843
135Abnormality of the lower motor neuron (HP:0002366)1.75236791
136Congenital primary aphakia (HP:0007707)1.74943573
137Capillary hemangiomas (HP:0005306)1.74824127
138Poor coordination (HP:0002370)1.73894973
139Gait imbalance (HP:0002141)1.73467902
140Atrophy/Degeneration involving motor neurons (HP:0007373)1.71854622
141Medulloblastoma (HP:0002885)1.71277880
142Neurodegeneration (HP:0002180)1.71142836
143Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.70646555
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.70617250
145Hypoplasia of the thymus (HP:0000778)1.70342383
146Posterior embryotoxon (HP:0000627)1.69481944
147Bone marrow hypocellularity (HP:0005528)1.68921865
148Hypoproteinemia (HP:0003075)1.67794234
149Increased hepatocellular lipid droplets (HP:0006565)1.67709743
150Anterior segment dysgenesis (HP:0007700)1.67532278
151Aplastic anemia (HP:0001915)1.65786598
152Aplasia/Hypoplasia of the patella (HP:0006498)1.64903905
153Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.64434108
154Abnormality of alanine metabolism (HP:0010916)1.64434108
155Hyperalaninemia (HP:0003348)1.64434108
156Polycystic ovaries (HP:0000147)1.60673050
157Decreased muscle mass (HP:0003199)1.60072962
158Rhabdomyosarcoma (HP:0002859)1.59669141
159Heterotopia (HP:0002282)1.59309583
160Adrenal hypoplasia (HP:0000835)1.58122043
161Hypoplasia of the capital femoral epiphysis (HP:0003090)1.58080820
162Male pseudohermaphroditism (HP:0000037)1.57999910
163Stage 5 chronic kidney disease (HP:0003774)1.57229168
164Postaxial foot polydactyly (HP:0001830)1.56137358
165Recurrent bronchitis (HP:0002837)1.56009513
166Oral leukoplakia (HP:0002745)1.55872003
167Abnormality of the line of Schwalbe (HP:0008048)1.54988605
168Nephrogenic diabetes insipidus (HP:0009806)1.51653501
169Abnormality of the epiphysis of the femoral head (HP:0010574)1.50692879
170Abnormality of the renal cortex (HP:0011035)1.49858011
171Sandal gap (HP:0001852)1.47715100
172Insulin-resistant diabetes mellitus (HP:0000831)1.47566487
173Ectopic kidney (HP:0000086)1.46038816
174Arterial tortuosity (HP:0005116)1.46029112
175Midline defect of the nose (HP:0004122)1.45900805
176Renovascular hypertension (HP:0100817)1.45663040
177Small intestinal stenosis (HP:0012848)1.45517374
178Duodenal stenosis (HP:0100867)1.45517374
179Carpal bone hypoplasia (HP:0001498)1.43949702
180Abnormal drinking behavior (HP:0030082)1.43820556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD34.34232754
2BMPR23.73447177
3MAP3K63.67919866
4MOS3.65859954
5MAP3K93.43728303
6KSR23.42040906
7PDK43.39073641
8PDK33.39073641
9LATS13.32363493
10CDK193.12367997
11ERBB42.88741169
12LATS22.87349450
13MAP3K132.69305667
14NUAK12.68952559
15SCYL22.56713901
16BRAF2.55680867
17PLK42.43551139
18TAOK32.38957434
19ZAK2.36514799
20TTK2.34920404
21STK38L2.34557639
22KIT2.16687257
23TESK12.15922938
24ARAF2.08449385
25EIF2AK32.08155431
26VRK22.06649533
27MST42.01951654
28PDK21.90962001
29BCKDK1.84158602
30TXK1.83538669
31NEK61.80755143
32CDK81.78462568
33STK31.67603504
34TNK21.58607336
35RAF11.57088792
36FES1.56941894
37MAP4K11.53200918
38EEF2K1.53025350
39STK241.52054451
40KSR11.50946731
41NEK21.49422324
42VRK11.41897528
43ACVR1B1.40879943
44CSF1R1.40681234
45MUSK1.37673487
46CDC71.36224904
47CHEK21.31032798
48TAOK11.31025595
49STK381.25048976
50MELK1.18470182
51TLK11.18259110
52TEC1.17839340
53BMPR1B1.17514854
54MAP3K41.13893465
55DYRK21.12150111
56PRKCI1.11332568
57MAP3K121.11142431
58PIM11.05315422
59MAP4K21.04259222
60MAPK131.03070174
61SRPK11.03001703
62NME20.99895547
63NLK0.98800753
64FLT30.95575583
65OXSR10.95357406
66PLK10.94988568
67RPS6KB20.94621838
68SYK0.93097379
69TRIM280.89470127
70PNCK0.88924194
71STK100.88363641
72CDK90.86503495
73CLK10.86313128
74MAP2K70.85655555
75ITK0.85100809
76MAPKAPK30.83960010
77TYRO30.83259950
78DAPK10.81396318
79GRK60.81115364
80ICK0.80742254
81PAK60.75328138
82TESK20.75271171
83ZAP700.72955882
84MAPKAPK50.71473009
85MAP3K20.70540136
86PRKCQ0.69955088
87MAP3K10.66252838
88RIPK40.65898176
89BTK0.64691458
90AURKA0.64400498
91TAF10.64305391
92LCK0.63228223
93WNK40.62140255
94IKBKB0.61775937
95MATK0.60659870
96PTK2B0.59892593
97MAP3K80.58581771
98ABL20.58433185
99PRKD20.56606599
100PBK0.54374196
101MAP2K40.53759625
102EIF2AK10.51469474
103LYN0.50331741
104PINK10.49795863
105RET0.49310024
106STK160.47108896
107IKBKE0.46913968
108DYRK30.46377552
109NTRK20.46174492
110CCNB10.45047330
111PIK3CG0.43569698
112RPS6KA40.42918413
113ATM0.42471626
114MAP3K50.42343448
115STK390.42105881
116CSNK2A20.42014609
117CDK20.40769944
118JAK30.40119281
119AURKB0.39354133
120MARK30.39058980
121MAP2K20.38965298
122MET0.38907045
123CHEK10.38867135
124PRKAA10.37426158
125CSNK2A10.37415475
126NEK90.37063097
127BRSK10.35032912
128MAP3K140.34681984
129CDK70.32192286
130TBK10.31461068
131TRPM70.30549630
132MARK20.28531721
133ATR0.27462374
134MAP2K10.25831230
135TYK20.23794829
136ABL10.23137131
137CDK120.20935220
138PLK20.20925089
139RPS6KA10.20886432
140MAPK110.20319374
141EIF2AK20.20247521
142CHUK0.20057499
143PLK30.18947901
144EPHA30.18232978
145PDK10.18078644
146CDK10.18073135
147PASK0.17233708
148HIPK20.16126538
149PAK10.14478073
150KDR0.13413419
151CSNK1G10.12850688
152YES10.12337099
153EPHA40.10857630
154CSNK1D0.10782013
155CSNK1G20.10041493
156NTRK30.09777090
157CAMK2A0.09585028
158BUB10.09529298

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.92536318
2Vitamin B6 metabolism_Homo sapiens_hsa007503.65251436
3Dorso-ventral axis formation_Homo sapiens_hsa043203.27018242
4Ovarian steroidogenesis_Homo sapiens_hsa049133.20851383
5RNA degradation_Homo sapiens_hsa030183.12646823
6Fanconi anemia pathway_Homo sapiens_hsa034602.95066486
7Oocyte meiosis_Homo sapiens_hsa041142.86527696
8Primary immunodeficiency_Homo sapiens_hsa053402.84602027
9Cell cycle_Homo sapiens_hsa041102.70107301
10Homologous recombination_Homo sapiens_hsa034402.66829468
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.59117979
12Linoleic acid metabolism_Homo sapiens_hsa005912.56045168
13Ribosome_Homo sapiens_hsa030102.22986546
14RNA transport_Homo sapiens_hsa030132.19873082
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17974573
16mRNA surveillance pathway_Homo sapiens_hsa030151.95525129
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.94692761
18Ether lipid metabolism_Homo sapiens_hsa005651.88160946
19Asthma_Homo sapiens_hsa053101.82041678
20Regulation of autophagy_Homo sapiens_hsa041401.75825849
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.73050497
22Allograft rejection_Homo sapiens_hsa053301.70475438
23Graft-versus-host disease_Homo sapiens_hsa053321.69079039
24Autoimmune thyroid disease_Homo sapiens_hsa053201.52923396
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52888342
26Pancreatic cancer_Homo sapiens_hsa052121.52227730
27Circadian rhythm_Homo sapiens_hsa047101.50275194
28Pyruvate metabolism_Homo sapiens_hsa006201.40461046
29GnRH signaling pathway_Homo sapiens_hsa049121.36566498
30Prolactin signaling pathway_Homo sapiens_hsa049171.35260717
31Spliceosome_Homo sapiens_hsa030401.34661842
32Fatty acid elongation_Homo sapiens_hsa000621.34556847
33Colorectal cancer_Homo sapiens_hsa052101.33566079
34Selenocompound metabolism_Homo sapiens_hsa004501.33541392
35Folate biosynthesis_Homo sapiens_hsa007901.32099880
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30885507
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30196160
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28278749
39RNA polymerase_Homo sapiens_hsa030201.20842905
40Type I diabetes mellitus_Homo sapiens_hsa049401.19496357
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.19242482
42Parkinsons disease_Homo sapiens_hsa050121.18738502
43Hematopoietic cell lineage_Homo sapiens_hsa046401.17585592
44TGF-beta signaling pathway_Homo sapiens_hsa043501.16622553
45Caffeine metabolism_Homo sapiens_hsa002321.16358625
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.15010475
47Base excision repair_Homo sapiens_hsa034101.12251771
48VEGF signaling pathway_Homo sapiens_hsa043701.11482367
49Nucleotide excision repair_Homo sapiens_hsa034201.10569774
50Mismatch repair_Homo sapiens_hsa034301.08483919
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.01483757
52Oxidative phosphorylation_Homo sapiens_hsa001900.99952589
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99738999
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.92124576
55Fatty acid biosynthesis_Homo sapiens_hsa000610.91678226
56Other glycan degradation_Homo sapiens_hsa005110.91431194
57Purine metabolism_Homo sapiens_hsa002300.90621044
58Inositol phosphate metabolism_Homo sapiens_hsa005620.90228993
59Glucagon signaling pathway_Homo sapiens_hsa049220.86945367
60Non-homologous end-joining_Homo sapiens_hsa034500.86076891
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85724932
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84002467
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81248987
64Protein export_Homo sapiens_hsa030600.81018550
65Phototransduction_Homo sapiens_hsa047440.80007292
66p53 signaling pathway_Homo sapiens_hsa041150.79494176
67Shigellosis_Homo sapiens_hsa051310.76579525
68Influenza A_Homo sapiens_hsa051640.76084366
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74753542
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74536053
71Long-term potentiation_Homo sapiens_hsa047200.73470334
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73122112
73Proteasome_Homo sapiens_hsa030500.72552528
74Choline metabolism in cancer_Homo sapiens_hsa052310.71382541
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68749232
76DNA replication_Homo sapiens_hsa030300.68419891
77Estrogen signaling pathway_Homo sapiens_hsa049150.65314265
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64811995
79MicroRNAs in cancer_Homo sapiens_hsa052060.64701257
80mTOR signaling pathway_Homo sapiens_hsa041500.62614870
81Rheumatoid arthritis_Homo sapiens_hsa053230.61545352
82Long-term depression_Homo sapiens_hsa047300.55560893
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55291689
84Pyrimidine metabolism_Homo sapiens_hsa002400.55273387
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55133260
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53975613
87Measles_Homo sapiens_hsa051620.53281875
88Ras signaling pathway_Homo sapiens_hsa040140.53077487
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52980654
90MAPK signaling pathway_Homo sapiens_hsa040100.52808674
91Herpes simplex infection_Homo sapiens_hsa051680.52606728
92HTLV-I infection_Homo sapiens_hsa051660.52545075
93Leishmaniasis_Homo sapiens_hsa051400.52405306
94Huntingtons disease_Homo sapiens_hsa050160.51849879
95Glycerolipid metabolism_Homo sapiens_hsa005610.51031562
96Sphingolipid metabolism_Homo sapiens_hsa006000.50321714
97One carbon pool by folate_Homo sapiens_hsa006700.49770169
98Renal cell carcinoma_Homo sapiens_hsa052110.49727712
99B cell receptor signaling pathway_Homo sapiens_hsa046620.49617343
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49315116
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.49259974
102Olfactory transduction_Homo sapiens_hsa047400.49087787
103Peroxisome_Homo sapiens_hsa041460.48429428
104ErbB signaling pathway_Homo sapiens_hsa040120.47816188
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46534184
106Viral myocarditis_Homo sapiens_hsa054160.44824825
107Hippo signaling pathway_Homo sapiens_hsa043900.44588462
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42713869
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42459382
110TNF signaling pathway_Homo sapiens_hsa046680.40451659
111Arachidonic acid metabolism_Homo sapiens_hsa005900.40138040
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.37312531
113Chronic myeloid leukemia_Homo sapiens_hsa052200.36878237
114Notch signaling pathway_Homo sapiens_hsa043300.36598749
115Endometrial cancer_Homo sapiens_hsa052130.36223972
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.35479340
117Pentose phosphate pathway_Homo sapiens_hsa000300.32601144
118Hepatitis B_Homo sapiens_hsa051610.32521860
119Epstein-Barr virus infection_Homo sapiens_hsa051690.32064230
120Viral carcinogenesis_Homo sapiens_hsa052030.32048777
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31985756
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31492951
123Antigen processing and presentation_Homo sapiens_hsa046120.31063331
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30481627
125Glioma_Homo sapiens_hsa052140.30322759
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.30038839
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29375423
128Glutamatergic synapse_Homo sapiens_hsa047240.29352334
129Acute myeloid leukemia_Homo sapiens_hsa052210.29042427
130ABC transporters_Homo sapiens_hsa020100.29039098
131Amphetamine addiction_Homo sapiens_hsa050310.28997279
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.28666217
133Wnt signaling pathway_Homo sapiens_hsa043100.28513788
134Legionellosis_Homo sapiens_hsa051340.28449215
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28374574
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27911624
137Melanoma_Homo sapiens_hsa052180.26907334
138Adherens junction_Homo sapiens_hsa045200.26328278
139Metabolic pathways_Homo sapiens_hsa011000.26182713
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.25437754
141Thyroid cancer_Homo sapiens_hsa052160.25256062
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25209915
143Propanoate metabolism_Homo sapiens_hsa006400.24956133
144Platelet activation_Homo sapiens_hsa046110.24954323
145Non-small cell lung cancer_Homo sapiens_hsa052230.24832547
146T cell receptor signaling pathway_Homo sapiens_hsa046600.23914456
147Bladder cancer_Homo sapiens_hsa052190.23797075
148Alzheimers disease_Homo sapiens_hsa050100.22454626
149Cholinergic synapse_Homo sapiens_hsa047250.21542468
150Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21175612
151Systemic lupus erythematosus_Homo sapiens_hsa053220.19079515
152Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17044951
153Taste transduction_Homo sapiens_hsa047420.15393073
154Collecting duct acid secretion_Homo sapiens_hsa049660.14431635
155Glutathione metabolism_Homo sapiens_hsa004800.12914248
156Staphylococcus aureus infection_Homo sapiens_hsa051500.10432434

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