HELLS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.62486921
2nuclear pore complex assembly (GO:0051292)5.52778350
3DNA unwinding involved in DNA replication (GO:0006268)5.25009274
4DNA replication initiation (GO:0006270)4.98477961
5DNA strand elongation involved in DNA replication (GO:0006271)4.74996418
6DNA double-strand break processing (GO:0000729)4.71328536
7DNA replication-dependent nucleosome assembly (GO:0006335)4.71042446
8DNA replication-dependent nucleosome organization (GO:0034723)4.71042446
9protein localization to kinetochore (GO:0034501)4.58044482
10DNA strand elongation (GO:0022616)4.51687101
11DNA replication checkpoint (GO:0000076)4.50079163
12kinetochore organization (GO:0051383)4.41365011
13telomere maintenance via semi-conservative replication (GO:0032201)4.36964806
14establishment of integrated proviral latency (GO:0075713)4.31125739
15pore complex assembly (GO:0046931)4.23977347
16mitotic metaphase plate congression (GO:0007080)4.23765806
17mitotic nuclear envelope disassembly (GO:0007077)4.19566950
18CENP-A containing nucleosome assembly (GO:0034080)4.15663792
19meiotic chromosome segregation (GO:0045132)4.11608312
20mitotic chromosome condensation (GO:0007076)4.11201660
21IMP biosynthetic process (GO:0006188)4.09787117
22mitotic recombination (GO:0006312)4.07634296
23telomere maintenance via recombination (GO:0000722)4.06724553
24* chromatin remodeling at centromere (GO:0031055)4.02800212
25replication fork processing (GO:0031297)4.00602210
26DNA replication-independent nucleosome organization (GO:0034724)3.96639953
27DNA replication-independent nucleosome assembly (GO:0006336)3.96639953
28regulation of posttranscriptional gene silencing (GO:0060147)3.93506777
29regulation of gene silencing by miRNA (GO:0060964)3.93506777
30regulation of gene silencing by RNA (GO:0060966)3.93506777
31attachment of spindle microtubules to kinetochore (GO:0008608)3.93311994
32metaphase plate congression (GO:0051310)3.92597815
33membrane disassembly (GO:0030397)3.91285798
34nuclear envelope disassembly (GO:0051081)3.91285798
35regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.89775038
36regulation of mitotic spindle checkpoint (GO:1903504)3.89775038
37nucleobase biosynthetic process (GO:0046112)3.89214945
38regulation of helicase activity (GO:0051095)3.88100148
39regulation of histone H3-K9 methylation (GO:0051570)3.86531772
40protein localization to chromosome, centromeric region (GO:0071459)3.85919495
41DNA geometric change (GO:0032392)3.84094677
42DNA duplex unwinding (GO:0032508)3.83273624
43mitotic sister chromatid cohesion (GO:0007064)3.80709319
44regulation of DNA endoreduplication (GO:0032875)3.79486133
45kinetochore assembly (GO:0051382)3.78166640
46somatic hypermutation of immunoglobulin genes (GO:0016446)3.76610960
47somatic diversification of immune receptors via somatic mutation (GO:0002566)3.76610960
48folic acid-containing compound biosynthetic process (GO:0009396)3.75698222
49DNA catabolic process, exonucleolytic (GO:0000738)3.75578110
50mitotic sister chromatid segregation (GO:0000070)3.75338797
51histone exchange (GO:0043486)3.72637995
52telomere maintenance via telomere lengthening (GO:0010833)3.71570006
53DNA ligation (GO:0006266)3.67348529
54protein K6-linked ubiquitination (GO:0085020)3.66206015
55double-strand break repair via nonhomologous end joining (GO:0006303)3.63209062
56non-recombinational repair (GO:0000726)3.63209062
57sister chromatid segregation (GO:0000819)3.62822876
58purine nucleobase biosynthetic process (GO:0009113)3.62009519
59IMP metabolic process (GO:0046040)3.60370269
60maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.59976014
61maturation of SSU-rRNA (GO:0030490)3.59381953
62nucleotide-excision repair, DNA gap filling (GO:0006297)3.57776420
63regulation of nuclear cell cycle DNA replication (GO:0033262)3.55392728
64synapsis (GO:0007129)3.46607245
65regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45721723
66ribosome assembly (GO:0042255)3.45416685
67establishment of chromosome localization (GO:0051303)3.45062797
68regulation of centrosome cycle (GO:0046605)3.40892331
69regulation of centriole replication (GO:0046599)3.40266166
70mitotic G2/M transition checkpoint (GO:0044818)3.39081379
71formation of translation preinitiation complex (GO:0001731)3.36325488
72DNA strand renaturation (GO:0000733)3.35616423
73positive regulation of chromosome segregation (GO:0051984)3.35550993
74negative regulation of histone methylation (GO:0031061)3.32044349
75spindle checkpoint (GO:0031577)3.32003333
76regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.31763377
77mismatch repair (GO:0006298)3.30339407
78* chromatin assembly or disassembly (GO:0006333)3.30298174
79proteasome assembly (GO:0043248)3.30211861
80negative regulation of chromosome segregation (GO:0051985)3.30014364
81regulation of chromosome segregation (GO:0051983)3.29379517
82spindle assembly checkpoint (GO:0071173)3.29194082
83negative regulation of DNA recombination (GO:0045910)3.28501065
84regulation of mitotic metaphase/anaphase transition (GO:0030071)3.28329602
85negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.26457052
86negative regulation of sister chromatid segregation (GO:0033046)3.26457052
87negative regulation of mitotic sister chromatid separation (GO:2000816)3.26457052
88negative regulation of mitotic sister chromatid segregation (GO:0033048)3.26457052
89regulation of double-strand break repair via homologous recombination (GO:0010569)3.25760772
90regulation of spindle organization (GO:0090224)3.25376343
91DNA conformation change (GO:0071103)3.24252972
92response to X-ray (GO:0010165)3.24107450
93recombinational repair (GO:0000725)3.20939724
94double-strand break repair via homologous recombination (GO:0000724)3.20926213
95regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.20790691
96mitotic spindle checkpoint (GO:0071174)3.20706935
97mitotic spindle assembly checkpoint (GO:0007094)3.20671498
98pre-miRNA processing (GO:0031054)3.19584047
99telomere maintenance (GO:0000723)3.19377639
100DNA damage response, detection of DNA damage (GO:0042769)3.17802863
101telomere organization (GO:0032200)3.17616490
102regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.17537739
103positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.16857041
104positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.16857041
105positive regulation of mitotic sister chromatid separation (GO:1901970)3.16857041
106negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16755891
107ATP-dependent chromatin remodeling (GO:0043044)3.15736369
108establishment of viral latency (GO:0019043)3.14970277
109regulation of sister chromatid segregation (GO:0033045)3.14201435
110regulation of mitotic sister chromatid separation (GO:0010965)3.14201435
111regulation of mitotic sister chromatid segregation (GO:0033047)3.14201435
112regulation of centrosome duplication (GO:0010824)3.14042056
113dosage compensation (GO:0007549)3.13414011
114ribosome biogenesis (GO:0042254)3.12398666
115intra-S DNA damage checkpoint (GO:0031573)3.11550674
116chromosome segregation (GO:0007059)3.10183756
117protein localization to chromosome (GO:0034502)3.09320764
118translesion synthesis (GO:0019985)3.09246745
119negative regulation of DNA-dependent DNA replication (GO:2000104)3.09184877
120regulation of sister chromatid cohesion (GO:0007063)3.08407282
121DNA synthesis involved in DNA repair (GO:0000731)3.07921781
122regulation of mitotic spindle organization (GO:0060236)3.07658406
123centriole replication (GO:0007099)3.07538826
124postreplication repair (GO:0006301)3.05195089
125regulation of meiosis I (GO:0060631)3.02979265
126telomere maintenance via telomerase (GO:0007004)3.00458959
127negative regulation of mitosis (GO:0045839)3.00166451
128somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.97608740
129somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.97608740
130isotype switching (GO:0045190)2.97608740
131L-serine metabolic process (GO:0006563)2.96022929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.87004272
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.38274774
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.09886235
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.42429854
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98429727
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75077582
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74010310
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.61804896
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.48568259
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43360412
11* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41163942
12AR_21909140_ChIP-Seq_LNCAP_Human2.39875563
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39787517
14* E2F1_21310950_ChIP-Seq_MCF-7_Human2.37958089
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36924936
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.30282893
17* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.22272300
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13608994
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06962540
20XRN2_22483619_ChIP-Seq_HELA_Human2.05655307
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.00805139
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.00717894
23E2F7_22180533_ChIP-Seq_HELA_Human11.3510954
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97282915
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.95427642
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93747936
27EWS_26573619_Chip-Seq_HEK293_Human1.92919997
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89874794
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.86701230
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84522743
31VDR_23849224_ChIP-Seq_CD4+_Human1.82673622
32KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.81598959
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.81598959
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.81598959
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80370323
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.78842502
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72863806
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72764237
39* FUS_26573619_Chip-Seq_HEK293_Human1.70180944
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68449374
41FOXP3_21729870_ChIP-Seq_TREG_Human1.66617548
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65687440
43ZNF274_21170338_ChIP-Seq_K562_Hela1.65103444
44TTF2_22483619_ChIP-Seq_HELA_Human1.62873440
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62682880
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61398551
47DCP1A_22483619_ChIP-Seq_HELA_Human1.58331366
48ELK1_19687146_ChIP-ChIP_HELA_Human1.57824385
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.55001255
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48778374
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47654370
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46935310
53* NANOG_16153702_ChIP-ChIP_HESCs_Human1.44903614
54VDR_22108803_ChIP-Seq_LS180_Human1.44053866
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44042600
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.42003572
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.41589309
58GABP_19822575_ChIP-Seq_HepG2_Human1.40285920
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40183531
60* SOX2_16153702_ChIP-ChIP_HESCs_Human1.40094878
61KDM5A_27292631_Chip-Seq_BREAST_Human1.35651051
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33649185
63CIITA_25753668_ChIP-Seq_RAJI_Human1.33051066
64* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33048970
65MYC_22102868_ChIP-Seq_BL_Human1.32438912
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31331040
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29895385
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27574151
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23900087
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22000226
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20764961
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19911305
73IGF1R_20145208_ChIP-Seq_DFB_Human1.19643065
74IRF1_19129219_ChIP-ChIP_H3396_Human1.19209891
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.18841361
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18105118
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17306127
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16210529
79* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13660126
80NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.11315352
81SRF_21415370_ChIP-Seq_HL-1_Mouse1.10391901
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09936794
83* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09246982
84* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07869124
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06731625
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05825320
87TAF15_26573619_Chip-Seq_HEK293_Human1.05771867
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05516942
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04685074
90TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04622422
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04376873
92TFEB_21752829_ChIP-Seq_HELA_Human1.04267842
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04263111
94* P300_19829295_ChIP-Seq_ESCs_Human1.03522290
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.03434675
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03381238
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01024940
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00522744
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98037969
100MYC_18940864_ChIP-ChIP_HL60_Human0.97212633
101NANOG_21062744_ChIP-ChIP_HESCs_Human0.96484220
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96037411
103* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94524941
104SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92864710
105NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92615546
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92070333
107* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91028468
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90550554
109ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90035536
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88991128
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88319282
112NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88298243
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87276424
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86675865
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83349656
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80958946
117SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.80637152
118PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79653841
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79398214
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.79157039
121* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.77193222
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76401131
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75398388
124SOX17_20123909_ChIP-Seq_XEN_Mouse0.73881313
125CTBP2_25329375_ChIP-Seq_LNCAP_Human0.72740078
126HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.72422485
127ZFP57_27257070_Chip-Seq_ESCs_Mouse0.72022977
128EZH2_27294783_Chip-Seq_NPCs_Mouse0.70907341
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.70761641
130RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.70363793
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.69367201

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.20724575
2MP0003693_abnormal_embryo_hatching4.78477284
3MP0008057_abnormal_DNA_replication4.52678903
4* MP0003111_abnormal_nucleus_morphology4.32598540
5MP0004957_abnormal_blastocyst_morpholog4.27249766
6MP0003077_abnormal_cell_cycle3.98773704
7MP0008877_abnormal_DNA_methylation3.60175635
8MP0008058_abnormal_DNA_repair3.59350137
9MP0009697_abnormal_copulation3.02579416
10MP0010352_gastrointestinal_tract_polyps2.82543512
11MP0008007_abnormal_cellular_replicative2.68847733
12MP0008932_abnormal_embryonic_tissue2.67182966
13MP0010307_abnormal_tumor_latency2.55685005
14MP0001730_embryonic_growth_arrest2.47915091
15* MP0000350_abnormal_cell_proliferation2.39345845
16MP0005380_embryogenesis_phenotype1.93583217
17MP0001672_abnormal_embryogenesis/_devel1.93583217
18MP0002938_white_spotting1.87059746
19MP0002396_abnormal_hematopoietic_system1.82466066
20MP0002085_abnormal_embryonic_tissue1.80442921
21* MP0001697_abnormal_embryo_size1.79700026
22MP0002084_abnormal_developmental_patter1.79173368
23* MP0003786_premature_aging1.78610438
24MP0002210_abnormal_sex_determination1.78386451
25MP0003890_abnormal_embryonic-extraembry1.76545346
26MP0005076_abnormal_cell_differentiation1.74589341
27* MP0004197_abnormal_fetal_growth/weight/1.71768838
28MP0003984_embryonic_growth_retardation1.70381142
29MP0001188_hyperpigmentation1.69858939
30MP0002088_abnormal_embryonic_growth/wei1.66658900
31MP0006072_abnormal_retinal_apoptosis1.63309651
32MP0002086_abnormal_extraembryonic_tissu1.60725729
33MP0002080_prenatal_lethality1.59445348
34MP0003941_abnormal_skin_development1.56902393
35MP0001145_abnormal_male_reproductive1.52886655
36MP0000490_abnormal_crypts_of1.46141075
37MP0001293_anophthalmia1.44809620
38MP0002102_abnormal_ear_morphology1.44778841
39MP0003567_abnormal_fetal_cardiomyocyte1.43409848
40MP0010030_abnormal_orbit_morphology1.41336220
41MP0001929_abnormal_gametogenesis1.38263246
42* MP0000313_abnormal_cell_death1.35263147
43MP0004808_abnormal_hematopoietic_stem1.32592068
44MP0002019_abnormal_tumor_incidence1.32210334
45MP0000653_abnormal_sex_gland1.31446738
46* MP0003121_genomic_imprinting1.28414341
47MP0003705_abnormal_hypodermis_morpholog1.25228926
48MP0000537_abnormal_urethra_morphology1.24416965
49MP0003718_maternal_effect1.22801570
50MP0008789_abnormal_olfactory_epithelium1.21548584
51* MP0003123_paternal_imprinting1.19995840
52MP0003315_abnormal_perineum_morphology1.19112821
53MP0000579_abnormal_nail_morphology1.18411942
54MP0002233_abnormal_nose_morphology1.18144977
55MP0003119_abnormal_digestive_system1.16837919
56MP0006035_abnormal_mitochondrial_morpho1.14477411
57MP0004133_heterotaxia1.13389970
58MP0003937_abnormal_limbs/digits/tail_de1.13002100
59MP0009053_abnormal_anal_canal1.12233399
60MP0002160_abnormal_reproductive_system1.10316089
61MP0008995_early_reproductive_senescence1.09879079
62MP0003806_abnormal_nucleotide_metabolis1.06016470
63MP0001529_abnormal_vocalization1.05292467
64MP0002751_abnormal_autonomic_nervous1.03005933
65MP0003787_abnormal_imprinting1.01348020
66MP0002254_reproductive_system_inflammat1.00979845
67MP0001119_abnormal_female_reproductive1.00154610
68MP0006292_abnormal_olfactory_placode0.99474533
69MP0002111_abnormal_tail_morphology0.96497760
70MP0001915_intracranial_hemorrhage0.91637335
71MP0000631_abnormal_neuroendocrine_gland0.90530118
72MP0001346_abnormal_lacrimal_gland0.89883062
73MP0000647_abnormal_sebaceous_gland0.89521718
74* MP0009703_decreased_birth_body0.88066819
75MP0001286_abnormal_eye_development0.87856999
76MP0005499_abnormal_olfactory_system0.87710393
77MP0005394_taste/olfaction_phenotype0.87710393
78MP0003566_abnormal_cell_adhesion0.87707358
79MP0000049_abnormal_middle_ear0.87036848
80MP0005389_reproductive_system_phenotype0.85038552
81MP0005391_vision/eye_phenotype0.84708496
82MP0001485_abnormal_pinna_reflex0.84077812
83MP0003698_abnormal_male_reproductive0.83004984
84MP0005253_abnormal_eye_physiology0.82163952
85* MP0000703_abnormal_thymus_morphology0.81879251
86MP0002092_abnormal_eye_morphology0.79625797
87MP0002653_abnormal_ependyma_morphology0.79534321
88MP0000432_abnormal_head_morphology0.79188558
89* MP0009672_abnormal_birth_weight0.77366531
90MP0002697_abnormal_eye_size0.76878279
91MP0003195_calcinosis0.75368983
92MP0005621_abnormal_cell_physiology0.75319793
93MP0000428_abnormal_craniofacial_morphol0.74561210
94MP0010234_abnormal_vibrissa_follicle0.73649756
95MP0005023_abnormal_wound_healing0.73436980
96* MP0001177_atelectasis0.72649081
97* MP0005384_cellular_phenotype0.72628891
98MP0000372_irregular_coat_pigmentation0.72038198
99MP0002090_abnormal_vision0.70655846
100MP0005367_renal/urinary_system_phenotyp0.70589672
101MP0000516_abnormal_urinary_system0.70589672
102MP0005395_other_phenotype0.69862851
103MP0005551_abnormal_eye_electrophysiolog0.69169803
104MP0003136_yellow_coat_color0.69070789
105MP0003861_abnormal_nervous_system0.68099411
106MP0001299_abnormal_eye_distance/0.67906170
107MP0001545_abnormal_hematopoietic_system0.67383745
108MP0005397_hematopoietic_system_phenotyp0.67383745
109MP0003936_abnormal_reproductive_system0.67251516
110MP0002736_abnormal_nociception_after0.66916023
111MP0004215_abnormal_myocardial_fiber0.65503377
112MP0003943_abnormal_hepatobiliary_system0.65033341
113MP0003938_abnormal_ear_development0.63774088
114MP0002161_abnormal_fertility/fecundity0.63023995
115MP0000427_abnormal_hair_cycle0.62066137
116MP0001849_ear_inflammation0.61874172
117MP0002234_abnormal_pharynx_morphology0.61805258
118MP0000477_abnormal_intestine_morphology0.61588469
119MP0004147_increased_porphyrin_level0.61432284
120MP0003115_abnormal_respiratory_system0.61319344
121MP0003935_abnormal_craniofacial_develop0.61112458
122MP0003755_abnormal_palate_morphology0.61031468
123MP0002925_abnormal_cardiovascular_devel0.60126521
124MP0003283_abnormal_digestive_organ0.59665512
125MP0003699_abnormal_female_reproductive0.59439395
126* MP0002398_abnormal_bone_marrow0.58905035
127MP0000858_altered_metastatic_potential0.58638074
128MP0004264_abnormal_extraembryonic_tissu0.57970499
129* MP0002722_abnormal_immune_system0.57557075
130MP0003763_abnormal_thymus_physiology0.56868702
131MP0002009_preneoplasia0.56349961
132MP0002877_abnormal_melanocyte_morpholog0.56305452
133MP0005623_abnormal_meninges_morphology0.55943971
134MP0000358_abnormal_cell_content/0.55066738
135MP0000566_synostosis0.54903536

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.04570241
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.70441954
3Birth length less than 3rd percentile (HP:0003561)4.49375088
4Ependymoma (HP:0002888)4.18365103
5Abnormality of chromosome stability (HP:0003220)3.93251556
6Medulloblastoma (HP:0002885)3.93221441
7Colon cancer (HP:0003003)3.78665287
8Abnormality of the labia minora (HP:0012880)3.71304060
9Reticulocytopenia (HP:0001896)3.53985768
10Breast hypoplasia (HP:0003187)3.41272151
11Agnosia (HP:0010524)3.37847180
12Meckel diverticulum (HP:0002245)3.37448555
13Selective tooth agenesis (HP:0001592)3.31504148
14Rhabdomyosarcoma (HP:0002859)3.26021302
15Aplasia/Hypoplasia of the uvula (HP:0010293)3.23109560
16Abnormality of the preputium (HP:0100587)3.22185021
17Abnormality of the ileum (HP:0001549)3.20126442
18Absent radius (HP:0003974)3.19790067
19Impulsivity (HP:0100710)3.06350965
20Absent thumb (HP:0009777)3.02213622
21Abnormality of the astrocytes (HP:0100707)3.00037843
22Astrocytoma (HP:0009592)3.00037843
23Aplasia involving forearm bones (HP:0009822)2.99879889
24Absent forearm bone (HP:0003953)2.99879889
25Patellar aplasia (HP:0006443)2.99708443
26Ectopic kidney (HP:0000086)2.96719858
27Supernumerary spleens (HP:0009799)2.95935536
28Volvulus (HP:0002580)2.84832730
29Glioma (HP:0009733)2.80923678
30Aplasia/Hypoplasia of the patella (HP:0006498)2.77593701
31Neoplasm of the oral cavity (HP:0100649)2.75887447
32Duodenal stenosis (HP:0100867)2.73450624
33Small intestinal stenosis (HP:0012848)2.73450624
34Proximal placement of thumb (HP:0009623)2.65139467
3511 pairs of ribs (HP:0000878)2.64881651
36Biliary tract neoplasm (HP:0100574)2.63608209
37Myelodysplasia (HP:0002863)2.60826014
38Deviation of the thumb (HP:0009603)2.59405693
39Duplicated collecting system (HP:0000081)2.59386811
40Increased nuchal translucency (HP:0010880)2.57795884
41Carpal bone hypoplasia (HP:0001498)2.56972247
42Missing ribs (HP:0000921)2.50860474
43Basal cell carcinoma (HP:0002671)2.48125431
44Oral leukoplakia (HP:0002745)2.48026453
45Abnormal number of incisors (HP:0011064)2.47250121
46Neoplasm of striated muscle (HP:0009728)2.45514592
47Abnormality of the carotid arteries (HP:0005344)2.43859387
48Abnormality of the anterior horn cell (HP:0006802)2.40142903
49Degeneration of anterior horn cells (HP:0002398)2.40142903
50Neoplasm of the pancreas (HP:0002894)2.38503829
51Septo-optic dysplasia (HP:0100842)2.37341702
52Sloping forehead (HP:0000340)2.34733478
53Abnormality of the duodenum (HP:0002246)2.32065920
54Abnormal lung lobation (HP:0002101)2.30615269
55Facial hemangioma (HP:0000329)2.26674700
56Short thumb (HP:0009778)2.24650651
57Cafe-au-lait spot (HP:0000957)2.24349155
58Abnormality of the renal collecting system (HP:0004742)2.24054059
59Abdominal situs inversus (HP:0003363)2.22774653
60Abnormality of abdominal situs (HP:0011620)2.22774653
61Horseshoe kidney (HP:0000085)2.22440181
62Tracheoesophageal fistula (HP:0002575)2.19958030
63Amaurosis fugax (HP:0100576)2.19293870
64Aplasia/hypoplasia of the humerus (HP:0006507)2.19011592
65Nephroblastoma (Wilms tumor) (HP:0002667)2.17355815
66Bone marrow hypocellularity (HP:0005528)2.17031496
67Atresia of the external auditory canal (HP:0000413)2.15427735
68Aplasia/Hypoplasia of the sternum (HP:0006714)2.10040422
69Pancreatic islet-cell hyperplasia (HP:0004510)2.08043636
70Triphalangeal thumb (HP:0001199)2.07429558
71Neoplasm of the colon (HP:0100273)2.05924352
72Intestinal atresia (HP:0011100)2.04219611
73Clubbing of toes (HP:0100760)2.01744256
74Embryonal renal neoplasm (HP:0011794)2.01638432
75Abnormal spermatogenesis (HP:0008669)2.01597248
76Abnormality of DNA repair (HP:0003254)2.01015937
77Gastrointestinal carcinoma (HP:0002672)1.99741192
78Malignant gastrointestinal tract tumors (HP:0006749)1.99741192
79Absent septum pellucidum (HP:0001331)1.99376312
80Squamous cell carcinoma (HP:0002860)1.99286606
81Abnormality of cochlea (HP:0000375)1.97992741
82Prominent nose (HP:0000448)1.97336335
83Ovarian neoplasm (HP:0100615)1.96914925
84Short humerus (HP:0005792)1.96774918
85Short 4th metacarpal (HP:0010044)1.96220906
86Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.96220906
87Abnormality of cells of the erythroid lineage (HP:0012130)1.95791424
88Abnormality of the septum pellucidum (HP:0007375)1.94737531
89Premature graying of hair (HP:0002216)1.93180294
90Abnormality of serum amino acid levels (HP:0003112)1.89170012
91High pitched voice (HP:0001620)1.88851940
92Bifid tongue (HP:0010297)1.88244740
93Rib fusion (HP:0000902)1.87945218
94Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86904037
95Hyperglycinemia (HP:0002154)1.86733300
96Sandal gap (HP:0001852)1.84120313
97Shawl scrotum (HP:0000049)1.84108922
98Increased hepatocellular lipid droplets (HP:0006565)1.84108680
99Rough bone trabeculation (HP:0100670)1.83919130
100Esophageal atresia (HP:0002032)1.82473150
101Asplenia (HP:0001746)1.82372334
102Megaloblastic anemia (HP:0001889)1.81863083
103Choanal atresia (HP:0000453)1.81753886
104Multiple enchondromatosis (HP:0005701)1.81207455
105Stenosis of the external auditory canal (HP:0000402)1.81025549
106Abnormal biliary tract morphology (HP:0012440)1.80801047
107Preaxial hand polydactyly (HP:0001177)1.79971556
108Abnormality of methionine metabolism (HP:0010901)1.79680029
109Supernumerary bones of the axial skeleton (HP:0009144)1.79614102
110Pancreatic fibrosis (HP:0100732)1.79045262
111Aplastic anemia (HP:0001915)1.77903485
112Embryonal neoplasm (HP:0002898)1.77766067
113Bilateral microphthalmos (HP:0007633)1.77670401
114Abnormality of the pons (HP:0007361)1.75952038
115Pancreatic cysts (HP:0001737)1.75942972
116Hypoplasia of the pons (HP:0012110)1.75849463
117Aqueductal stenosis (HP:0002410)1.75403771
118Hyperglycinuria (HP:0003108)1.75262471
119Abnormality of pyrimidine metabolism (HP:0004353)1.74931488
120Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74323046
121Irregular epiphyses (HP:0010582)1.74307744
122Gonadotropin excess (HP:0000837)1.73835491
123Skull defect (HP:0001362)1.73709764
124Nephronophthisis (HP:0000090)1.73154732
125Supernumerary ribs (HP:0005815)1.72808048
126Oligodactyly (hands) (HP:0001180)1.72657993
127Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71515070
128Pendular nystagmus (HP:0012043)1.71393578
129Neoplasm of the rectum (HP:0100743)1.71210632
130Cortical dysplasia (HP:0002539)1.71100104
131High anterior hairline (HP:0009890)1.70919453
132Breast carcinoma (HP:0003002)1.70406407
133Acute encephalopathy (HP:0006846)1.70076673
134Arteriovenous malformation (HP:0100026)1.69796899
135Neoplasm of the adrenal cortex (HP:0100641)1.69426494
136Dandy-Walker malformation (HP:0001305)1.69021496
137Small hand (HP:0200055)1.68955624
138Abnormality of glycine metabolism (HP:0010895)1.68186318
139Abnormality of serine family amino acid metabolism (HP:0010894)1.68186318
140Gastrointestinal atresia (HP:0002589)1.67245971
141Molar tooth sign on MRI (HP:0002419)1.67168219
142Abnormality of midbrain morphology (HP:0002418)1.67168219
143Acute necrotizing encephalopathy (HP:0006965)1.66128417
144Astigmatism (HP:0000483)1.65587508
145True hermaphroditism (HP:0010459)1.65323215
146Duplication of thumb phalanx (HP:0009942)1.64399166
147Facial cleft (HP:0002006)1.63100384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.58595568
2WEE14.19941002
3CDK123.40859414
4NEK23.01495288
5SRPK12.98624075
6BUB12.97239192
7NUAK12.96186269
8TTK2.87410005
9ACVR1B2.67002866
10VRK22.63701393
11NEK12.52283413
12EIF2AK12.22071408
13BRSK22.18965805
14PLK12.18817503
15MKNK12.17465177
16TAF12.16648879
17ATR2.11705040
18PASK2.09226093
19TSSK62.00093221
20TNIK1.99124614
21MKNK21.88656697
22PLK31.88289096
23PLK41.87038760
24WNK31.86159396
25CDK71.85467606
26TLK11.83096397
27RPS6KB21.82719964
28TRIM281.78490071
29AURKB1.76984739
30BMPR1B1.76136657
31EPHA21.73648990
32CHEK21.72727500
33BRD41.64161414
34CHEK11.60091844
35SCYL21.57371516
36CDK41.52403641
37ZAK1.46563761
38VRK11.44301616
39ATM1.34372303
40EIF2AK31.34156957
41MAP3K81.30769205
42STK41.27748283
43DYRK31.24463984
44EEF2K1.22632655
45BRSK11.13446249
46AURKA1.11943604
47PLK21.10322577
48RPS6KA41.09933417
49CDK21.09119186
50PNCK1.06326066
51ALK1.04750762
52TGFBR11.02791197
53STK101.02651420
54FLT30.99963627
55CDK60.98166493
56MELK0.96567455
57FRK0.96554998
58TESK20.95211948
59PKN20.94784971
60NME10.91722098
61STK38L0.90195972
62CDK10.85837740
63MAP4K20.84443505
64STK30.83720152
65PAK40.83521609
66MAP3K100.82719388
67PBK0.82487242
68PIM10.80947367
69CSNK1G10.75195115
70CSNK2A20.73713944
71OXSR10.72029881
72BCR0.71338511
73DYRK20.69740409
74NLK0.69488120
75STK160.67315723
76NME20.67224142
77LATS10.66776355
78CDK80.66521977
79CCNB10.64143970
80CDK30.61931323
81CSNK1D0.60760897
82CAMK1G0.60665919
83FGFR20.60434575
84CLK10.60294354
85PRKDC0.59848238
86CDK190.59816954
87ERBB40.59815830
88CSNK2A10.59661521
89GRK10.59426139
90MTOR0.59351389
91EIF2AK20.53742654
92INSRR0.53572015
93RPS6KA50.52860480
94PRKCI0.52290590
95STK390.51040255
96CSNK1E0.50862111
97MAPK140.44077567
98CSNK1G20.43074910
99CDK90.42719916
100PAK10.40914038
101CSNK1G30.40791960
102FGFR10.37762137
103MAP3K40.37329383
104CSNK1A1L0.36380534
105CASK0.36355689
106CAMK1D0.34936906
107AKT20.34911482
108AKT10.34525116
109AKT30.33626198
110LATS20.33625703
111IRAK20.32324856
112MET0.32257125
113GSK3B0.31677472
114TESK10.31675066
115STK240.31663516
116BRAF0.31220525
117RPS6KB10.31093569
118YES10.29160355
119PRKCG0.28328653
120MAPK10.25851408
121PDK40.25043341
122PDK30.25043341
123MARK30.24951768
124SMG10.24581531
125PAK20.22327938
126LRRK20.21455831
127MST40.20119186
128ERBB30.18967379
129DAPK10.18909191
130IRAK10.18499072
131CSNK1A10.18226673
132TTN0.16916484
133MAPKAPK30.12958678
134PDK20.12818029
135RPS6KA10.12118336
136MAP2K30.11153934
137CHUK0.10764347

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.21458645
2Mismatch repair_Homo sapiens_hsa034304.80451809
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.93571091
4Homologous recombination_Homo sapiens_hsa034403.47848360
5Spliceosome_Homo sapiens_hsa030403.34032986
6RNA transport_Homo sapiens_hsa030133.29473082
7One carbon pool by folate_Homo sapiens_hsa006703.15906779
8Cell cycle_Homo sapiens_hsa041103.09805452
9Nucleotide excision repair_Homo sapiens_hsa034203.06165361
10Base excision repair_Homo sapiens_hsa034102.95704245
11Fanconi anemia pathway_Homo sapiens_hsa034602.82778075
12RNA polymerase_Homo sapiens_hsa030202.67006932
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.62252881
14Non-homologous end-joining_Homo sapiens_hsa034502.60953316
15Ribosome_Homo sapiens_hsa030102.34129897
16mRNA surveillance pathway_Homo sapiens_hsa030152.15622609
17Basal transcription factors_Homo sapiens_hsa030222.15071688
18Pyrimidine metabolism_Homo sapiens_hsa002402.10530061
19RNA degradation_Homo sapiens_hsa030182.08763151
20Proteasome_Homo sapiens_hsa030502.02906469
21Protein export_Homo sapiens_hsa030601.92100784
22Systemic lupus erythematosus_Homo sapiens_hsa053221.71465477
23p53 signaling pathway_Homo sapiens_hsa041151.68458549
24Propanoate metabolism_Homo sapiens_hsa006401.59053688
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34999215
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30918203
27Pyruvate metabolism_Homo sapiens_hsa006201.27282502
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25235720
29Vitamin B6 metabolism_Homo sapiens_hsa007501.23486022
30Viral carcinogenesis_Homo sapiens_hsa052031.18969023
31Steroid biosynthesis_Homo sapiens_hsa001001.17883516
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17550104
33Oxidative phosphorylation_Homo sapiens_hsa001901.16829663
34Parkinsons disease_Homo sapiens_hsa050121.15318776
35Purine metabolism_Homo sapiens_hsa002301.12207866
36Oocyte meiosis_Homo sapiens_hsa041141.11854290
37Epstein-Barr virus infection_Homo sapiens_hsa051691.10459259
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07564637
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03107217
40Herpes simplex infection_Homo sapiens_hsa051681.00254772
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97204876
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96278281
43MicroRNAs in cancer_Homo sapiens_hsa052060.96061173
44Antigen processing and presentation_Homo sapiens_hsa046120.93570444
45Selenocompound metabolism_Homo sapiens_hsa004500.91114092
46Fatty acid elongation_Homo sapiens_hsa000620.90515942
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87845055
48HTLV-I infection_Homo sapiens_hsa051660.87245263
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81206812
50Thyroid cancer_Homo sapiens_hsa052160.78294198
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.73710427
52Alcoholism_Homo sapiens_hsa050340.72600048
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71748043
54TGF-beta signaling pathway_Homo sapiens_hsa043500.71347534
55Small cell lung cancer_Homo sapiens_hsa052220.71195728
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67516938
57Caffeine metabolism_Homo sapiens_hsa002320.64655941
58Hippo signaling pathway_Homo sapiens_hsa043900.63464140
59Basal cell carcinoma_Homo sapiens_hsa052170.63176799
60Biosynthesis of amino acids_Homo sapiens_hsa012300.61215126
61Phototransduction_Homo sapiens_hsa047440.60281257
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.59082506
63Alzheimers disease_Homo sapiens_hsa050100.55301867
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52806996
65Colorectal cancer_Homo sapiens_hsa052100.52316383
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51684817
67Adherens junction_Homo sapiens_hsa045200.51152596
68Metabolic pathways_Homo sapiens_hsa011000.50670115
69Vitamin digestion and absorption_Homo sapiens_hsa049770.50210328
70Notch signaling pathway_Homo sapiens_hsa043300.47549256
71Pentose phosphate pathway_Homo sapiens_hsa000300.46781961
72Lysine degradation_Homo sapiens_hsa003100.46213435
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44950691
74Butanoate metabolism_Homo sapiens_hsa006500.43979097
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42049884
76Legionellosis_Homo sapiens_hsa051340.41582446
77Tryptophan metabolism_Homo sapiens_hsa003800.41313312
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.40974617
79Pathways in cancer_Homo sapiens_hsa052000.38045005
80Fatty acid degradation_Homo sapiens_hsa000710.37190860
81Apoptosis_Homo sapiens_hsa042100.36518329
82Fatty acid metabolism_Homo sapiens_hsa012120.35914950
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.35802713
84Bladder cancer_Homo sapiens_hsa052190.35691321
85Prostate cancer_Homo sapiens_hsa052150.35459105
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35442270
87Retinol metabolism_Homo sapiens_hsa008300.35167769
88Hepatitis B_Homo sapiens_hsa051610.34453428
89Hedgehog signaling pathway_Homo sapiens_hsa043400.33043139
90Nitrogen metabolism_Homo sapiens_hsa009100.32193770
91beta-Alanine metabolism_Homo sapiens_hsa004100.31216262
92Ether lipid metabolism_Homo sapiens_hsa005650.31083494
93Glutathione metabolism_Homo sapiens_hsa004800.30513147
94Peroxisome_Homo sapiens_hsa041460.30192956
95Chronic myeloid leukemia_Homo sapiens_hsa052200.30155164
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29311104
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.28667122
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28345580
99Influenza A_Homo sapiens_hsa051640.27955745
100HIF-1 signaling pathway_Homo sapiens_hsa040660.27033152
101Tight junction_Homo sapiens_hsa045300.26547537
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26477008
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26187447
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26176658
105Melanoma_Homo sapiens_hsa052180.24945356
106mTOR signaling pathway_Homo sapiens_hsa041500.24900157
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24832507
108Folate biosynthesis_Homo sapiens_hsa007900.23842298
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23831123
110Wnt signaling pathway_Homo sapiens_hsa043100.23731100
111Measles_Homo sapiens_hsa051620.22835377
112Viral myocarditis_Homo sapiens_hsa054160.22337600
113Arginine and proline metabolism_Homo sapiens_hsa003300.21228542
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21196271
115Chemical carcinogenesis_Homo sapiens_hsa052040.20835198
116Nicotine addiction_Homo sapiens_hsa050330.19459697
117Primary immunodeficiency_Homo sapiens_hsa053400.18931523
118Non-small cell lung cancer_Homo sapiens_hsa052230.18843847
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18537749
120Sulfur relay system_Homo sapiens_hsa041220.17902520
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17551519
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16899172
123Linoleic acid metabolism_Homo sapiens_hsa005910.16585585
124Proteoglycans in cancer_Homo sapiens_hsa052050.16377448
125Carbon metabolism_Homo sapiens_hsa012000.15977211
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15927128
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15667671
128Cardiac muscle contraction_Homo sapiens_hsa042600.15610893
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15534287
130FoxO signaling pathway_Homo sapiens_hsa040680.14776699
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14220195
132Pancreatic cancer_Homo sapiens_hsa052120.12542665
133Shigellosis_Homo sapiens_hsa051310.12108367
134N-Glycan biosynthesis_Homo sapiens_hsa005100.11581476
135Renin-angiotensin system_Homo sapiens_hsa046140.10915800
136Endometrial cancer_Homo sapiens_hsa052130.10900822
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.10845270
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08373631
139Acute myeloid leukemia_Homo sapiens_hsa052210.08183835
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.05686096
141Huntingtons disease_Homo sapiens_hsa050160.05542666
142Hematopoietic cell lineage_Homo sapiens_hsa046400.05484500
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.04810540
144Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.03577145
145RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.01254705

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