HECTD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.20244102
2synaptic vesicle maturation (GO:0016188)4.47357878
3regulation of ARF protein signal transduction (GO:0032012)4.13649337
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.12146154
5cerebellar granule cell differentiation (GO:0021707)4.01990463
6cerebellar Purkinje cell differentiation (GO:0021702)3.91186764
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.79737152
8regulation of synaptic vesicle exocytosis (GO:2000300)3.67308336
9ionotropic glutamate receptor signaling pathway (GO:0035235)3.63486109
10cytoskeletal anchoring at plasma membrane (GO:0007016)3.60455280
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.56057929
12glutamate secretion (GO:0014047)3.55825779
13synaptic vesicle exocytosis (GO:0016079)3.53644883
14locomotory exploration behavior (GO:0035641)3.40240481
15histone H3-K4 trimethylation (GO:0080182)3.32453609
16vocalization behavior (GO:0071625)3.27714457
17positive regulation of synapse maturation (GO:0090129)3.27494428
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.21241428
19cell differentiation in hindbrain (GO:0021533)3.14050983
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12037362
21establishment of nucleus localization (GO:0040023)3.11600262
22regulation of synaptic vesicle transport (GO:1902803)3.11086514
23L-amino acid import (GO:0043092)3.09344910
24neurotransmitter secretion (GO:0007269)3.03017800
25neuronal ion channel clustering (GO:0045161)3.02276485
26cell migration in hindbrain (GO:0021535)2.99336798
27sodium ion export (GO:0071436)2.98662262
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.97746067
29regulation of NFAT protein import into nucleus (GO:0051532)2.95714243
30regulation of neuronal synaptic plasticity (GO:0048168)2.94877048
31regulation of glutamate receptor signaling pathway (GO:1900449)2.92849194
32cellular potassium ion homeostasis (GO:0030007)2.91981252
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.88840898
34neurotransmitter-gated ion channel clustering (GO:0072578)2.85185295
35dendritic spine morphogenesis (GO:0060997)2.78845779
36neuromuscular process controlling balance (GO:0050885)2.78557299
37membrane depolarization during action potential (GO:0086010)2.77381464
38synaptic transmission, glutamatergic (GO:0035249)2.75697089
39glutamate receptor signaling pathway (GO:0007215)2.73129313
40nerve growth factor signaling pathway (GO:0038180)2.72521081
41postsynaptic membrane organization (GO:0001941)2.71120181
42glucocorticoid receptor signaling pathway (GO:0042921)2.69529121
43regulation of synapse maturation (GO:0090128)2.69277773
44exploration behavior (GO:0035640)2.68855905
45negative regulation of dendrite morphogenesis (GO:0050774)2.68024394
46regulation of long-term neuronal synaptic plasticity (GO:0048169)2.67177098
47synaptic vesicle endocytosis (GO:0048488)2.66725019
48positive regulation of Rap GTPase activity (GO:0032854)2.65161887
49histone H3-K9 demethylation (GO:0033169)2.64423049
50activation of protein kinase A activity (GO:0034199)2.63728175
51histone H3-K36 demethylation (GO:0070544)2.61933615
52amino acid import (GO:0043090)2.61550656
53nucleus localization (GO:0051647)2.60115600
54central nervous system projection neuron axonogenesis (GO:0021952)2.59284305
55histone H3-K4 methylation (GO:0051568)2.58274437
56axonal fasciculation (GO:0007413)2.58188884
57regulation of Rap GTPase activity (GO:0032317)2.56695912
58long-term memory (GO:0007616)2.55090585
59regulation of neurotransmitter secretion (GO:0046928)2.54990493
60embryonic retina morphogenesis in camera-type eye (GO:0060059)2.54678120
61G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.54184615
62insulin-like growth factor receptor signaling pathway (GO:0048009)2.53044330
63positive regulation of CREB transcription factor activity (GO:0032793)2.52684203
64negative regulation of neurotransmitter secretion (GO:0046929)2.50121874
65positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.49119000
66positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.48547512
67phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.48021191
68peptidyl-threonine phosphorylation (GO:0018107)2.46914568
69neuronal action potential propagation (GO:0019227)2.46165099
70protein localization to synapse (GO:0035418)2.45711247
71auditory behavior (GO:0031223)2.45501349
72neuron recognition (GO:0008038)2.45185252
73neuron cell-cell adhesion (GO:0007158)2.44109413
74cell communication by electrical coupling (GO:0010644)2.42702087
75regulation of synaptic plasticity (GO:0048167)2.42390350
76regulation of excitatory postsynaptic membrane potential (GO:0060079)2.42271463
77layer formation in cerebral cortex (GO:0021819)2.42085244
78histone lysine methylation (GO:0034968)2.41329304
79regulation of dendrite morphogenesis (GO:0048814)2.40260598
80regulation of ARF GTPase activity (GO:0032312)2.38984345
81regulation of postsynaptic membrane potential (GO:0060078)2.38720767
82neurotransmitter transport (GO:0006836)2.38604591
83neuron-neuron synaptic transmission (GO:0007270)2.38598031
84protein targeting to plasma membrane (GO:0072661)2.37398156
85neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.37352043
86gamma-aminobutyric acid transport (GO:0015812)2.37074157
87dendrite morphogenesis (GO:0048813)2.36068907
88histone lysine demethylation (GO:0070076)2.35961437
89interkinetic nuclear migration (GO:0022027)2.34243367
90cytoplasmic mRNA processing body assembly (GO:0033962)2.33231006
91regulation of clathrin-mediated endocytosis (GO:2000369)2.33122019
92positive regulation of membrane potential (GO:0045838)2.31950247
93corticosteroid receptor signaling pathway (GO:0031958)2.31246239
94cellular response to monoamine stimulus (GO:0071868)2.30833682
95cellular response to catecholamine stimulus (GO:0071870)2.30833682
96macroautophagy (GO:0016236)2.28132782
97membrane depolarization (GO:0051899)2.26174985
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.25901449
99regulation of synapse structural plasticity (GO:0051823)2.25763359
100positive regulation of dendrite development (GO:1900006)2.25231722

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.23570296
2DROSHA_22980978_ChIP-Seq_HELA_Human3.05659252
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.89097568
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.57503356
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08722337
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.07768544
7REST_21632747_ChIP-Seq_MESCs_Mouse1.97559210
8RNF2_27304074_Chip-Seq_ESCs_Mouse1.90631723
9TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.89744119
10AR_21572438_ChIP-Seq_LNCaP_Human1.88027621
11KDM2B_26808549_Chip-Seq_K562_Human1.86921206
12GBX2_23144817_ChIP-Seq_PC3_Human1.84036185
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83876619
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.82937540
15JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82740308
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77786128
17KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76410808
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74103428
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73562673
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73562673
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73042753
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72536621
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71181251
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70722841
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70048774
26CTNNB1_20460455_ChIP-Seq_HCT116_Human1.67929762
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.66960147
28GATA1_19941826_ChIP-Seq_K562_Human1.60246219
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.57986662
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57026129
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56866933
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54586344
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53831258
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53327852
35WT1_25993318_ChIP-Seq_PODOCYTE_Human1.51762620
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50811226
37DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.50331998
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45610476
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.44699459
40TCF7_22412390_ChIP-Seq_EML_Mouse1.41991486
41KDM2B_26808549_Chip-Seq_DND41_Human1.41194933
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40649514
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.38698167
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38108508
45SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36976003
46GATA1_22025678_ChIP-Seq_K562_Human1.36476546
47AHR_22903824_ChIP-Seq_MCF-7_Human1.34248288
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34222905
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32714706
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32375939
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32247099
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30980472
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.29948675
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.28806878
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26846498
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26410074
57AR_19668381_ChIP-Seq_PC3_Human1.24919799
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24544382
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22889865
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22726997
61YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22387581
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.19486121
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19238792
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.18344169
65SCL_19346495_ChIP-Seq_HPC-7_Human1.17627418
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17110617
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16531892
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.16326244
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.14910122
70ISL1_27105846_Chip-Seq_CPCs_Mouse1.11761597
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11656934
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10019802
73TP53_16413492_ChIP-PET_HCT116_Human1.09025899
74GATA2_19941826_ChIP-Seq_K562_Human1.08700671
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08311683
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08070638
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.06281974
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05462695
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03796735
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.02618792
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.01967891
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01849164
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01849164
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.00722303
85ERG_21242973_ChIP-ChIP_JURKAT_Human0.98694505
86CREB1_26743006_Chip-Seq_LNCaP_Human0.98422321
87STAT3_23295773_ChIP-Seq_U87_Human0.97775655
88NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97527612
89SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97338018
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97300164
91IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96704976
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95502189
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94712730
94SMAD4_21799915_ChIP-Seq_A2780_Human0.94475148
95STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93752496
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93482953
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.93121935
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92922312
99TCF4_23295773_ChIP-Seq_U87_Human0.92370388
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91752136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.24274421
2MP0004270_analgesia3.55064614
3MP0003635_abnormal_synaptic_transmissio3.20550606
4MP0005423_abnormal_somatic_nervous3.17519405
5MP0003880_abnormal_central_pattern2.74973569
6MP0002822_catalepsy2.66634445
7MP0002063_abnormal_learning/memory/cond2.66122227
8MP0002064_seizures2.63900585
9MP0005409_darkened_coat_color2.42767526
10MP0003879_abnormal_hair_cell2.39274118
11MP0009046_muscle_twitch2.35763135
12MP0002734_abnormal_mechanical_nocicepti2.21856417
13MP0009745_abnormal_behavioral_response2.21327023
14MP0004147_increased_porphyrin_level2.17574181
15MP0001486_abnormal_startle_reflex2.12167185
16MP0008569_lethality_at_weaning2.05280305
17MP0000778_abnormal_nervous_system2.03105549
18MP0001501_abnormal_sleep_pattern2.01735268
19MP0002272_abnormal_nervous_system1.96737687
20MP0002572_abnormal_emotion/affect_behav1.92771407
21MP0003329_amyloid_beta_deposits1.86135500
22MP0003045_fibrosis1.83695324
23MP0005076_abnormal_cell_differentiation1.81523198
24MP0002735_abnormal_chemical_nociception1.80119591
25MP0000569_abnormal_digit_pigmentation1.77159471
26MP0003787_abnormal_imprinting1.70293684
27MP0003656_abnormal_erythrocyte_physiolo1.69871138
28MP0001502_abnormal_circadian_rhythm1.67233308
29MP0004811_abnormal_neuron_physiology1.65761328
30MP0003690_abnormal_glial_cell1.64984069
31MP0004130_abnormal_muscle_cell1.61890171
32MP0002009_preneoplasia1.59863758
33MP0002067_abnormal_sensory_capabilities1.59290219
34MP0000955_abnormal_spinal_cord1.53053754
35MP0001968_abnormal_touch/_nociception1.47861128
36MP0003172_abnormal_lysosome_physiology1.46510962
37MP0002882_abnormal_neuron_morphology1.41124528
38MP0001348_abnormal_lacrimal_gland1.41046865
39MP0001970_abnormal_pain_threshold1.40209399
40MP0004924_abnormal_behavior1.40054369
41MP0005386_behavior/neurological_phenoty1.40054369
42MP0004145_abnormal_muscle_electrophysio1.39619262
43MP0002733_abnormal_thermal_nociception1.39303864
44MP0003633_abnormal_nervous_system1.37433106
45MP0002557_abnormal_social/conspecific_i1.37241840
46MP0003631_nervous_system_phenotype1.36056506
47MP0001440_abnormal_grooming_behavior1.34766522
48MP0002184_abnormal_innervation1.32459654
49MP0003632_abnormal_nervous_system1.32092776
50MP0002152_abnormal_brain_morphology1.23463901
51MP0004885_abnormal_endolymph1.23135165
52MP0005645_abnormal_hypothalamus_physiol1.20164908
53MP0003122_maternal_imprinting1.19976041
54MP0002066_abnormal_motor_capabilities/c1.19909907
55MP0009780_abnormal_chondrocyte_physiolo1.19903614
56MP0003634_abnormal_glial_cell1.12293044
57MP0003123_paternal_imprinting1.11351694
58MP0002249_abnormal_larynx_morphology1.10751652
59MP0005646_abnormal_pituitary_gland1.08604236
60MP0008961_abnormal_basal_metabolism1.05697136
61MP0000920_abnormal_myelination1.02143304
62MP0001177_atelectasis1.01874094
63MP0006276_abnormal_autonomic_nervous1.01805063
64MP0002909_abnormal_adrenal_gland0.99661194
65MP0002229_neurodegeneration0.97231299
66MP0003705_abnormal_hypodermis_morpholog0.95459701
67MP0004742_abnormal_vestibular_system0.94877550
68MP0008057_abnormal_DNA_replication0.88735410
69MP0003861_abnormal_nervous_system0.84075340
70MP0009278_abnormal_bone_marrow0.82286539
71MP0004043_abnormal_pH_regulation0.81257412
72MP0001943_abnormal_respiration0.77387472
73MP0010769_abnormal_survival0.76216627
74MP0003091_abnormal_cell_migration0.75660785
75MP0004036_abnormal_muscle_relaxation0.74515668
76MP0001188_hyperpigmentation0.74240895
77MP0004858_abnormal_nervous_system0.74018722
78MP0010770_preweaning_lethality0.74005051
79MP0002082_postnatal_lethality0.74005051
80MP0010768_mortality/aging0.72210274
81MP0004510_myositis0.71220702
82MP0000003_abnormal_adipose_tissue0.70870221
83MP0001299_abnormal_eye_distance/0.69525994
84MP0000733_abnormal_muscle_development0.67764532
85MP0003283_abnormal_digestive_organ0.66380697
86MP0000747_muscle_weakness0.66034373
87MP0005666_abnormal_adipose_tissue0.65812598
88MP0001984_abnormal_olfaction0.63695883
89MP0005375_adipose_tissue_phenotype0.63414819
90MP0003890_abnormal_embryonic-extraembry0.62188518
91MP0005167_abnormal_blood-brain_barrier0.60980184
92MP0001545_abnormal_hematopoietic_system0.60608496
93MP0005397_hematopoietic_system_phenotyp0.60608496
94MP0008874_decreased_physiological_sensi0.60338928
95MP0003948_abnormal_gas_homeostasis0.60249477
96MP0003115_abnormal_respiratory_system0.59855679
97MP0002081_perinatal_lethality0.59137131
98MP0001731_abnormal_postnatal_growth0.58258121
99MP0002069_abnormal_eating/drinking_beha0.58200781
100MP0005310_abnormal_salivary_gland0.57004919

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.61137613
2Genetic anticipation (HP:0003743)4.04970853
3Abnormality of the fingertips (HP:0001211)3.96973168
4Myokymia (HP:0002411)3.58332649
5Progressive cerebellar ataxia (HP:0002073)3.56756206
6Febrile seizures (HP:0002373)3.46984679
7Focal seizures (HP:0007359)3.45779889
8Focal motor seizures (HP:0011153)3.26787975
9Dysmetric saccades (HP:0000641)3.22380478
10Abnormality of binocular vision (HP:0011514)3.09937128
11Diplopia (HP:0000651)3.09937128
12Macroorchidism (HP:0000053)3.03420084
13Action tremor (HP:0002345)2.98082867
14Hyperventilation (HP:0002883)2.94624676
15Epileptic encephalopathy (HP:0200134)2.94084213
16Urinary bladder sphincter dysfunction (HP:0002839)2.74413860
17Ankle clonus (HP:0011448)2.73745353
18Postural instability (HP:0002172)2.73270283
19Broad face (HP:0000283)2.66738825
20Truncal ataxia (HP:0002078)2.57011357
21Atonic seizures (HP:0010819)2.54175248
22Supranuclear gaze palsy (HP:0000605)2.48934238
23Heterotopia (HP:0002282)2.42323243
24Narrow palate (HP:0000189)2.41518606
25Bronchomalacia (HP:0002780)2.40349572
26Spastic gait (HP:0002064)2.40316622
27Cerebral aneurysm (HP:0004944)2.38691717
28Neoplasm of the heart (HP:0100544)2.37087773
29Papilledema (HP:0001085)2.36868825
30Impaired smooth pursuit (HP:0007772)2.35378856
31Truncal obesity (HP:0001956)2.34022536
32Gaze-evoked nystagmus (HP:0000640)2.32124892
33Germ cell neoplasia (HP:0100728)2.28567917
34Hyperacusis (HP:0010780)2.26214800
35Broad-based gait (HP:0002136)2.23752001
36Stereotypic behavior (HP:0000733)2.23137361
37Protruding tongue (HP:0010808)2.22936672
38Sleep apnea (HP:0010535)2.22445759
39Neurofibrillary tangles (HP:0002185)2.20028491
40Overgrowth (HP:0001548)2.18546968
41Long eyelashes (HP:0000527)2.18442963
42Cerebral inclusion bodies (HP:0100314)2.17124352
43Hemiplegia (HP:0002301)2.04030689
44Abnormality of ocular smooth pursuit (HP:0000617)2.03393629
45Visual hallucinations (HP:0002367)2.02903048
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02067525
47Laryngomalacia (HP:0001601)2.01185493
48Drooling (HP:0002307)2.01168821
49Insomnia (HP:0100785)2.00754547
50Sporadic (HP:0003745)2.00450204
51Absence seizures (HP:0002121)1.97828771
52Poikilocytosis (HP:0004447)1.97034248
53Tapered finger (HP:0001182)1.96859813
54Absent speech (HP:0001344)1.93830629
55Dysdiadochokinesis (HP:0002075)1.91441253
56Poor eye contact (HP:0000817)1.91435250
57Excessive salivation (HP:0003781)1.89537350
58Epileptiform EEG discharges (HP:0011182)1.89424352
59Deeply set eye (HP:0000490)1.88273728
60Precocious puberty (HP:0000826)1.88037883
61Tracheomalacia (HP:0002779)1.87201249
62Dialeptic seizures (HP:0011146)1.86494953
63Impaired social interactions (HP:0000735)1.85960358
64Abnormal social behavior (HP:0012433)1.85960358
65Depression (HP:0000716)1.84191039
66Difficulty running (HP:0009046)1.83335100
67Neonatal hypoglycemia (HP:0001998)1.83331236
68Impaired vibratory sensation (HP:0002495)1.83223005
69Shallow orbits (HP:0000586)1.79652129
70Onion bulb formation (HP:0003383)1.79523942
71Dysmetria (HP:0001310)1.79288427
72Thick eyebrow (HP:0000574)1.78738132
73Pointed chin (HP:0000307)1.77749311
74Lower limb muscle weakness (HP:0007340)1.77329511
75Abnormality of the distal phalanx of the thumb (HP:0009617)1.77024321
76Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76463608
77Lower limb amyotrophy (HP:0007210)1.75606607
78Hyperkalemia (HP:0002153)1.74644582
79EEG with generalized epileptiform discharges (HP:0011198)1.74614707
80Abnormality of the aortic arch (HP:0012303)1.74599575
81Vertebral arch anomaly (HP:0008438)1.72424652
82Obsessive-compulsive behavior (HP:0000722)1.71829787
83Prolonged QT interval (HP:0001657)1.70134380
84Abnormality of the ischium (HP:0003174)1.68383757
85Renovascular hypertension (HP:0100817)1.66970360
86Annular pancreas (HP:0001734)1.66423830
87Scanning speech (HP:0002168)1.65982010
88Blue irides (HP:0000635)1.65871233
89Decreased motor nerve conduction velocity (HP:0003431)1.64956448
90Tented upper lip vermilion (HP:0010804)1.64589607
91Open mouth (HP:0000194)1.64320226
92Abnormality of the corticospinal tract (HP:0002492)1.63363509
93Abnormality of the heme biosynthetic pathway (HP:0010472)1.63350019
94Abnormality of the columella (HP:0009929)1.63241266
95Abnormality of incisor morphology (HP:0011063)1.62510762
96Hypsarrhythmia (HP:0002521)1.62440938
97Bowel incontinence (HP:0002607)1.60340586
98Mask-like facies (HP:0000298)1.59686979
99EMG: neuropathic changes (HP:0003445)1.58421774
100Urethral obstruction (HP:0000796)1.57229678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.25584806
2NTRK33.08278553
3CAMK1D2.94300015
4MARK12.84244840
5TRIB32.79830543
6CAMK1G2.69357678
7ICK2.20375780
8MARK22.10241860
9SIK22.09906798
10SGK22.03566802
11PRPF4B2.00842456
12EEF2K1.99646032
13AKT31.99626407
14NTRK21.99019966
15EPHA41.89351957
16CASK1.86856627
17SGK4941.83430314
18SGK2231.83430314
19WNK11.79198838
20CAMKK11.78503456
21SGK31.75049793
22DAPK21.74185972
23RIPK11.50855398
24BRD41.44245637
25UHMK11.30944093
26MAP3K71.30124573
27TNK21.24767443
28PRKD31.20457143
29TYRO31.20046412
30CDC42BPA1.18206744
31MTOR1.18102627
32PRKCH1.14350981
33STK381.11348271
34FGFR21.09840597
35PAK61.09269872
36CAMK41.08915728
37SGK11.08267948
38MAP3K91.07747143
39RET1.05939437
40STK111.05260536
41RIPK41.03813278
42CAMK11.03696187
43NTRK10.98645823
44FGFR30.97576017
45TAOK10.96230827
46MAPK120.93787163
47KSR20.93666670
48CDK50.92932565
49SIK10.91694614
50MAP3K130.90953173
51HIPK20.86180514
52PKN20.82150446
53MAP2K40.82069411
54MAPK100.78989059
55RPS6KA20.77437941
56MAP3K60.76805829
57MAPK130.76668013
58PRKAA10.76550124
59DYRK1A0.75810575
60FGFR40.75627921
61PRKD20.73555263
62MAP3K20.73278853
63PDGFRA0.72904548
64FRK0.72521057
65MINK10.70286787
66ERBB20.69987970
67PDK10.67676789
68PDGFRB0.64911430
69MAP3K40.60773878
70PDPK10.60710006
71PRKAA20.58757886
72MAP3K100.58700148
73KSR10.58368442
74NEK60.58283419
75EPHA30.57786867
76RPS6KA30.57081408
77MAPK80.56549255
78TRPM70.55073807
79PRKCZ0.52772557
80JAK10.51266261
81MAP3K10.49573897
82GSK3B0.48028003
83MAPK70.46711928
84CAMKK20.45195665
85MAPK110.44592073
86MAP2K30.44387949
87DMPK0.44058923
88LATS20.44000703
89PHKG20.43476140
90PHKG10.43476140
91CAMK2B0.39611189
92PAK30.37239235
93BMX0.36655713
94RPS6KL10.36082868
95RPS6KC10.36082868
96FYN0.35268044
97PKN10.34946383
98MAPK10.33508779
99JAK20.33487219
100AKT10.33230562

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.18785509
2Long-term potentiation_Homo sapiens_hsa047202.16516734
3Glutamatergic synapse_Homo sapiens_hsa047241.86148788
4Circadian entrainment_Homo sapiens_hsa047131.81715970
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72208828
6Phosphatidylinositol signaling system_Homo sapiens_hsa040701.71776547
7Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65944456
8Synaptic vesicle cycle_Homo sapiens_hsa047211.65455288
9Insulin secretion_Homo sapiens_hsa049111.65018031
10Cholinergic synapse_Homo sapiens_hsa047251.64944864
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64454887
12Amphetamine addiction_Homo sapiens_hsa050311.58559199
13GABAergic synapse_Homo sapiens_hsa047271.52158399
14Morphine addiction_Homo sapiens_hsa050321.49382160
15GnRH signaling pathway_Homo sapiens_hsa049121.46345862
16Type II diabetes mellitus_Homo sapiens_hsa049301.46310489
17Gastric acid secretion_Homo sapiens_hsa049711.42077532
18Glioma_Homo sapiens_hsa052141.41203509
19Dopaminergic synapse_Homo sapiens_hsa047281.41173075
20ErbB signaling pathway_Homo sapiens_hsa040121.40936220
21Estrogen signaling pathway_Homo sapiens_hsa049151.37465656
22Thyroid hormone signaling pathway_Homo sapiens_hsa049191.35312607
23Phospholipase D signaling pathway_Homo sapiens_hsa040721.34729179
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34594545
25Cocaine addiction_Homo sapiens_hsa050301.34562981
26Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34429362
27Inositol phosphate metabolism_Homo sapiens_hsa005621.31444120
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30431397
29Oxytocin signaling pathway_Homo sapiens_hsa049211.30092890
30Long-term depression_Homo sapiens_hsa047301.29169524
31Choline metabolism in cancer_Homo sapiens_hsa052311.27642188
32Salivary secretion_Homo sapiens_hsa049701.27193272
33Non-small cell lung cancer_Homo sapiens_hsa052231.25870428
34Dorso-ventral axis formation_Homo sapiens_hsa043201.25562134
35mTOR signaling pathway_Homo sapiens_hsa041501.24638452
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24551019
37VEGF signaling pathway_Homo sapiens_hsa043701.22875756
38Endometrial cancer_Homo sapiens_hsa052131.20429504
39Renin secretion_Homo sapiens_hsa049241.19147940
40Longevity regulating pathway - mammal_Homo sapiens_hsa042111.18426354
41cAMP signaling pathway_Homo sapiens_hsa040241.18339627
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.18141384
43Lysine degradation_Homo sapiens_hsa003101.17871142
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16193367
45Calcium signaling pathway_Homo sapiens_hsa040201.11331007
46Renal cell carcinoma_Homo sapiens_hsa052111.10410778
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09958717
48Notch signaling pathway_Homo sapiens_hsa043301.09049166
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08784377
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08221592
51Chronic myeloid leukemia_Homo sapiens_hsa052201.07909019
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.02573277
53Gap junction_Homo sapiens_hsa045400.98713680
54Thyroid hormone synthesis_Homo sapiens_hsa049180.95975562
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95514593
56Taste transduction_Homo sapiens_hsa047420.95238907
57Axon guidance_Homo sapiens_hsa043600.94198013
58Melanogenesis_Homo sapiens_hsa049160.93462394
59Prolactin signaling pathway_Homo sapiens_hsa049170.93154387
60MAPK signaling pathway_Homo sapiens_hsa040100.90583651
61Acute myeloid leukemia_Homo sapiens_hsa052210.89119066
62B cell receptor signaling pathway_Homo sapiens_hsa046620.87678284
63AMPK signaling pathway_Homo sapiens_hsa041520.87114744
64Pancreatic secretion_Homo sapiens_hsa049720.87021719
65Insulin signaling pathway_Homo sapiens_hsa049100.86346900
66Circadian rhythm_Homo sapiens_hsa047100.86014297
67ABC transporters_Homo sapiens_hsa020100.84325214
68FoxO signaling pathway_Homo sapiens_hsa040680.84309647
69Glucagon signaling pathway_Homo sapiens_hsa049220.83726342
70Serotonergic synapse_Homo sapiens_hsa047260.82677909
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80914554
72Dilated cardiomyopathy_Homo sapiens_hsa054140.80226003
73Platelet activation_Homo sapiens_hsa046110.78681472
74Prostate cancer_Homo sapiens_hsa052150.78482307
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77970437
76Bile secretion_Homo sapiens_hsa049760.77800384
77Pancreatic cancer_Homo sapiens_hsa052120.77589879
78Rap1 signaling pathway_Homo sapiens_hsa040150.77502187
79Fatty acid biosynthesis_Homo sapiens_hsa000610.77349142
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74244849
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74220318
82Colorectal cancer_Homo sapiens_hsa052100.73559737
83Ras signaling pathway_Homo sapiens_hsa040140.70183620
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.67088144
85MicroRNAs in cancer_Homo sapiens_hsa052060.65671281
86Insulin resistance_Homo sapiens_hsa049310.64513234
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.63303112
88Adherens junction_Homo sapiens_hsa045200.63039053
89Focal adhesion_Homo sapiens_hsa045100.59682376
90Ovarian steroidogenesis_Homo sapiens_hsa049130.59655985
91T cell receptor signaling pathway_Homo sapiens_hsa046600.55350192
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53958913
93HIF-1 signaling pathway_Homo sapiens_hsa040660.50111107
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49968665
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.49020894
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48821607
97Alcoholism_Homo sapiens_hsa050340.47550288
98Proteoglycans in cancer_Homo sapiens_hsa052050.47162081
99Endocytosis_Homo sapiens_hsa041440.45925591
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43147477

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