HECA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits terminal branching of neighboring cells during tracheal development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)4.38462779
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.38462779
3positive regulation of gamma-delta T cell activation (GO:0046645)4.32940604
4cellular extravasation (GO:0045123)4.28245058
5positive regulation by symbiont of host defense response (GO:0052509)4.26814478
6modulation by symbiont of host defense response (GO:0052031)4.26814478
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.26814478
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.26814478
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.26814478
10modulation by symbiont of host immune response (GO:0052553)4.26814478
11regulation of gamma-delta T cell differentiation (GO:0045586)4.12590440
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.10459673
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.10459673
14negative regulation of T cell mediated immunity (GO:0002710)3.95481920
15detection of other organism (GO:0098543)3.90575555
16activated T cell proliferation (GO:0050798)3.87491285
17positive thymic T cell selection (GO:0045059)3.83530623
18macrophage activation involved in immune response (GO:0002281)3.80602733
19negative regulation of lymphocyte mediated immunity (GO:0002707)3.78996154
20regulation of gamma-delta T cell activation (GO:0046643)3.75781448
21negative regulation of interleukin-12 production (GO:0032695)3.72310588
22antigen processing and presentation of endogenous antigen (GO:0019883)3.72304686
23neutrophil activation involved in immune response (GO:0002283)3.70552257
24detection of molecule of bacterial origin (GO:0032490)3.64751976
25detection of bacterium (GO:0016045)3.59441246
26cellular response to interleukin-15 (GO:0071350)3.55859767
27alpha-linolenic acid metabolic process (GO:0036109)3.52697848
28T cell migration (GO:0072678)3.51997982
29response to muramyl dipeptide (GO:0032495)3.46569537
30detection of external biotic stimulus (GO:0098581)3.45638156
31positive regulation of histone deacetylation (GO:0031065)3.44545468
32positive regulation of fatty acid beta-oxidation (GO:0032000)3.44189286
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.43316484
34B cell receptor signaling pathway (GO:0050853)3.43117706
35regulation of cholesterol homeostasis (GO:2000188)3.42595980
36positive T cell selection (GO:0043368)3.38979233
37response to peptidoglycan (GO:0032494)3.38961188
38microglial cell activation (GO:0001774)3.38945909
39regulation of tolerance induction (GO:0002643)3.37132928
40negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.35719308
41negative T cell selection (GO:0043383)3.34016441
42thymic T cell selection (GO:0045061)3.31308157
43positive regulation of B cell differentiation (GO:0045579)3.30779879
44negative regulation of leukocyte mediated immunity (GO:0002704)3.29114266
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.28968264
46positive regulation of tolerance induction (GO:0002645)3.28123816
47germinal center formation (GO:0002467)3.27412623
48negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.26720809
49negative regulation of T-helper cell differentiation (GO:0045623)3.26720809
50positive regulation of granulocyte differentiation (GO:0030854)3.26211004
51regulation of B cell differentiation (GO:0045577)3.25595524
52negative thymic T cell selection (GO:0045060)3.23489898
53regulation of alpha-beta T cell proliferation (GO:0046640)3.22257488
54regulation of interferon-beta biosynthetic process (GO:0045357)3.19063494
55macrophage activation (GO:0042116)3.16961381
56urea cycle (GO:0000050)3.16589477
57urea metabolic process (GO:0019627)3.16589477
58regulation of fatty acid beta-oxidation (GO:0031998)3.16497843
59neutrophil activation (GO:0042119)3.15088066
60complement activation, alternative pathway (GO:0006957)3.14676653
61detection of biotic stimulus (GO:0009595)3.10873487
62negative regulation of erythrocyte differentiation (GO:0045647)3.10858094
63triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.10292000
64myeloid cell activation involved in immune response (GO:0002275)3.08842296
65T cell selection (GO:0045058)3.07747424
66neutrophil mediated immunity (GO:0002446)3.07697542
67phospholipid homeostasis (GO:0055091)3.07218545
68phospholipid efflux (GO:0033700)3.07040010
69negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.03762131
70regulation of regulatory T cell differentiation (GO:0045589)3.03695965
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.01581353
72L-phenylalanine catabolic process (GO:0006559)3.01581353
73regulation of interleukin-12 biosynthetic process (GO:0045075)2.98660502
74response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96769144
75response to host immune response (GO:0052572)2.96769144
76peptidyl-glutamic acid carboxylation (GO:0017187)2.95351121
77protein carboxylation (GO:0018214)2.95351121
78lysine catabolic process (GO:0006554)2.93381500
79lysine metabolic process (GO:0006553)2.93381500
80myeloid leukocyte mediated immunity (GO:0002444)2.92754002
81regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.89584309
82response to interleukin-15 (GO:0070672)2.87997926
83granulocyte activation (GO:0036230)2.87889069
84T cell homeostasis (GO:0043029)2.87160161
85phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.86781615
86regulation of protein activation cascade (GO:2000257)2.85678145
87negative regulation of fibrinolysis (GO:0051918)2.85039519
88L-phenylalanine metabolic process (GO:0006558)2.84911641
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.84911641
90negative regulation of adaptive immune response (GO:0002820)2.84869562
91regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83761660
92antigen processing and presentation via MHC class Ib (GO:0002475)2.83493771
93respiratory burst (GO:0045730)2.82479540
94positive regulation of lipid catabolic process (GO:0050996)2.81360291
95antigen receptor-mediated signaling pathway (GO:0050851)2.80929140
96growth hormone receptor signaling pathway (GO:0060396)2.80854497
97B cell homeostasis (GO:0001782)2.80476677
98JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.80220059
99response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.79637470
100response to host (GO:0075136)2.79637470
101response to host defenses (GO:0052200)2.79637470
102kynurenine metabolic process (GO:0070189)2.79512439
103defense response to protozoan (GO:0042832)2.78978849
104valine metabolic process (GO:0006573)2.78885844
105aromatic amino acid family catabolic process (GO:0009074)2.78803335
106regulation of cholesterol storage (GO:0010885)2.78211010
107dicarboxylic acid biosynthetic process (GO:0043650)2.77698899
108T-helper cell differentiation (GO:0042093)2.77634126
109CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.77634126
110dendritic cell migration (GO:0036336)2.77174852
111histone H3-K36 demethylation (GO:0070544)2.76449587
112type I interferon signaling pathway (GO:0060337)2.75863819
113cellular response to type I interferon (GO:0071357)2.75863819
114regulation of triglyceride catabolic process (GO:0010896)2.75706669
115immunoglobulin mediated immune response (GO:0016064)2.75486134
116sulfur amino acid catabolic process (GO:0000098)2.74980791
117response to type I interferon (GO:0034340)2.74747624
118positive regulation of alpha-beta T cell proliferation (GO:0046641)2.74107942
119positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.73802542
120alpha-beta T cell differentiation (GO:0046632)2.73401310
121nitrogen cycle metabolic process (GO:0071941)2.72451000
122cysteine metabolic process (GO:0006534)2.72290616
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.72206505
124mast cell activation (GO:0045576)2.71882294
125regulation of complement activation (GO:0030449)2.71352278
126positive regulation of fatty acid oxidation (GO:0046321)2.70839683
127regulation of natural killer cell mediated immunity (GO:0002715)2.70827229
128regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.70827229
129T cell receptor signaling pathway (GO:0050852)2.70608026
130plasma lipoprotein particle assembly (GO:0034377)2.68049722
131protein localization to endosome (GO:0036010)2.67837319
132negative regulation of sterol transport (GO:0032372)2.67179944
133negative regulation of cholesterol transport (GO:0032375)2.67179944
134bile acid biosynthetic process (GO:0006699)2.66538006
135regulation of T cell mediated cytotoxicity (GO:0001914)2.66497344
1362-oxoglutarate metabolic process (GO:0006103)2.66347855
137protein-lipid complex assembly (GO:0065005)2.61441757
138high-density lipoprotein particle remodeling (GO:0034375)2.59890241
139low-density lipoprotein particle clearance (GO:0034383)2.59557306
140fatty acid transmembrane transport (GO:1902001)2.57267078
141homocysteine metabolic process (GO:0050667)2.56761011
142plasma lipoprotein particle clearance (GO:0034381)2.56426422
143indole-containing compound catabolic process (GO:0042436)2.53365989
144indolalkylamine catabolic process (GO:0046218)2.53365989
145tryptophan catabolic process (GO:0006569)2.53365989
146regulation of T cell tolerance induction (GO:0002664)2.50463069
147interferon-gamma production (GO:0032609)2.48699555
148negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.48077787
149regulation of fibrinolysis (GO:0051917)2.47285724
150tryptophan metabolic process (GO:0006568)2.46899637
151positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42791672
152cytoplasmic mRNA processing body assembly (GO:0033962)2.42454899
153amino-acid betaine metabolic process (GO:0006577)2.40694706
154reverse cholesterol transport (GO:0043691)2.40528392
155leukocyte aggregation (GO:0070486)2.39319917
156glyoxylate metabolic process (GO:0046487)2.38879729
157tolerance induction (GO:0002507)2.38253983
158positive regulation of sterol transport (GO:0032373)2.37540724
159positive regulation of cholesterol transport (GO:0032376)2.37540724
160bile acid metabolic process (GO:0008206)2.37309650
161cellular response to growth hormone stimulus (GO:0071378)2.35797227
162positive regulation of humoral immune response (GO:0002922)2.35786467
163positive regulation of p38MAPK cascade (GO:1900745)2.34989594
164response to laminar fluid shear stress (GO:0034616)2.34269353
165positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.32871733
166carnitine shuttle (GO:0006853)2.32771703
167negative regulation of lipid transport (GO:0032369)2.32116013
168regulation of fatty acid oxidation (GO:0046320)2.31807404
169ethanol oxidation (GO:0006069)2.31766469
170positive regulation of lipid storage (GO:0010884)2.30582280
171positive regulation of cholesterol efflux (GO:0010875)2.28428898
172cholesterol efflux (GO:0033344)2.27192548
173regulation of B cell receptor signaling pathway (GO:0050855)2.26489086
174positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.26040806
175triglyceride homeostasis (GO:0070328)2.25918999
176acylglycerol homeostasis (GO:0055090)2.25918999
177regulation of lipid catabolic process (GO:0050994)2.25348534

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.58239776
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.03551021
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.83502843
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.65690734
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.50801758
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.32285616
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.18571386
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.00916573
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.99146133
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.55749286
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.45943312
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.29977144
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.28380509
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.26464497
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.26119147
16* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24720472
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.22773773
18RUNX_20019798_ChIP-Seq_JUKART_Human2.20662903
19GATA1_22025678_ChIP-Seq_K562_Human2.09133977
20MYC_22102868_ChIP-Seq_BL_Human2.06757558
21CLOCK_20551151_ChIP-Seq_293T_Human2.06224930
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.01344671
23TCF7_22412390_ChIP-Seq_EML_Mouse2.00155088
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94799109
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.89895865
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89379833
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88705851
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.87075827
29SPI1_23547873_ChIP-Seq_NB4_Human1.81542909
30MAF_26560356_Chip-Seq_TH1_Human1.81037048
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.78910123
32KDM2B_26808549_Chip-Seq_DND41_Human1.70803432
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67629782
34PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67179706
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67053031
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64141801
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63993648
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61896920
39* MYB_26560356_Chip-Seq_TH2_Human1.61447097
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59685336
41* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59464437
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56453989
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53115888
44UTX_26944678_Chip-Seq_JUKART_Human1.53106196
45MYB_26560356_Chip-Seq_TH1_Human1.51653844
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48886454
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45505891
48GATA3_26560356_Chip-Seq_TH2_Human1.45134220
49RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.43819861
50* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41122781
51GATA1_19941826_ChIP-Seq_K562_Human1.41087830
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39615877
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37878602
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35618926
55FOXA2_19822575_ChIP-Seq_HepG2_Human1.34735217
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30823198
57PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30631327
58VDR_21846776_ChIP-Seq_THP-1_Human1.29038072
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28848029
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.28733863
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.27554692
62GATA2_19941826_ChIP-Seq_K562_Human1.25976443
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25758167
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.25152509
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24752783
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.24668089
67* MAF_26560356_Chip-Seq_TH2_Human1.22496532
68* GATA3_27048872_Chip-Seq_THYMUS_Human1.21483119
69SCL_19346495_ChIP-Seq_HPC-7_Human1.20954123
70ZNF263_19887448_ChIP-Seq_K562_Human1.20752985
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20142278
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19382338
73TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.18890057
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16748077
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16470560
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.13770698
77SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12863573
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11850332
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11727972
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11547885
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.10058974
82TBX20_22328084_ChIP-Seq_HEART_Mouse1.09771957
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.09771957
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09059403
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08657544
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08599888
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07831104
88SPI1_23127762_ChIP-Seq_K562_Human1.06150246
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05879276
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.05207551
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04620331
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03536077
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02679023
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02663852
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.02474517
96VDR_24763502_ChIP-Seq_THP-1_Human1.01422499
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00897597
98RUNX1_27514584_Chip-Seq_MCF-7_Human1.00357402
99VDR_24787735_ChIP-Seq_THP-1_Human1.00147785
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99994175
101FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99907126
102SMRT_27268052_Chip-Seq_Bcells_Human0.98514818
103P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98338784
104ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97582904
105RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97523475
106GATA1_19941827_ChIP-Seq_MEL_Mouse0.97506516
107GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97398269
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96828040
109GATA6_25053715_ChIP-Seq_YYC3_Human0.96641108
110NCOR1_26117541_ChIP-Seq_K562_Human0.96156252
111* PU_27001747_Chip-Seq_BMDM_Mouse0.96113027
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96000675
113RACK7_27058665_Chip-Seq_MCF-7_Human0.94585787
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94482828
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94470889
116SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94470889
117KDM2B_26808549_Chip-Seq_K562_Human0.93181621
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.91591060
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91324045
120PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90391627
121CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84746420
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.83899078
123GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83862059
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81397041
125KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.80914491
126* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.74767472
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.72417261
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72116642
129VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.71132529
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70921100
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.70218111
132PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69618951
133GATA1_22383799_ChIP-Seq_G1ME_Mouse0.65213696
134* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.62093562
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.62056543
136PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61907093
137* EZH2_27294783_Chip-Seq_NPCs_Mouse0.61891518
138GATA3_26560356_Chip-Seq_TH1_Human0.60825007
139TP53_16413492_ChIP-PET_HCT116_Human0.58281011
140* TP63_23658742_ChIP-Seq_EP156T_Human0.57737191
141SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.57011452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.76975840
2MP0005360_urolithiasis3.69039531
3MP0010234_abnormal_vibrissa_follicle3.24250499
4MP0005365_abnormal_bile_salt3.14975202
5MP0005085_abnormal_gallbladder_physiolo2.91043569
6MP0003300_gastrointestinal_ulcer2.88953971
7MP0003705_abnormal_hypodermis_morpholog2.44086500
8MP0003252_abnormal_bile_duct2.41517155
9MP0003191_abnormal_cellular_cholesterol2.35460773
10MP0003303_peritoneal_inflammation2.33330252
11MP0002138_abnormal_hepatobiliary_system2.33057704
12MP0008875_abnormal_xenobiotic_pharmacok2.31441364
13MP0002166_altered_tumor_susceptibility2.23045799
14MP0003828_pulmonary_edema2.15629710
15MP0004947_skin_inflammation2.06827091
16MP0002148_abnormal_hypersensitivity_rea2.05382708
17MP0000685_abnormal_immune_system2.01887850
18MP0009840_abnormal_foam_cell2.01512013
19MP0010329_abnormal_lipoprotein_level1.96769938
20MP0008260_abnormal_autophagy1.92458731
21MP0004381_abnormal_hair_follicle1.88821284
22MP0003763_abnormal_thymus_physiology1.86994638
23MP0003436_decreased_susceptibility_to1.85831482
24MP0009333_abnormal_splenocyte_physiolog1.80555902
25MP0005387_immune_system_phenotype1.79840312
26MP0001790_abnormal_immune_system1.79840312
27MP0001800_abnormal_humoral_immune1.79093768
28MP0000609_abnormal_liver_physiology1.78534345
29MP0000569_abnormal_digit_pigmentation1.76938305
30MP0001851_eye_inflammation1.68766785
31MP0004510_myositis1.67757062
32MP0004130_abnormal_muscle_cell1.65590452
33MP0003172_abnormal_lysosome_physiology1.62291421
34MP0002006_tumorigenesis1.60285340
35MP0008961_abnormal_basal_metabolism1.60259286
36MP0005083_abnormal_biliary_tract1.59589390
37MP0004185_abnormal_adipocyte_glucose1.59342059
38MP0003566_abnormal_cell_adhesion1.57981863
39MP0005310_abnormal_salivary_gland1.56420351
40MP0010352_gastrointestinal_tract_polyps1.48823154
41MP0001666_abnormal_nutrient_absorption1.47856976
42MP0004883_abnormal_blood_vessel1.47191816
43MP0001835_abnormal_antigen_presentation1.45715901
44MP0005076_abnormal_cell_differentiation1.41999362
45MP0002998_abnormal_bone_remodeling1.41597685
46MP0005000_abnormal_immune_tolerance1.39946351
47MP0002723_abnormal_immune_serum1.39893842
48MP0002452_abnormal_antigen_presenting1.38789148
49MP0009278_abnormal_bone_marrow1.36987224
50MP0002009_preneoplasia1.36694000
51MP0005275_abnormal_skin_tensile1.34724921
52MP0005671_abnormal_response_to1.33698936
53MP0003453_abnormal_keratinocyte_physiol1.30400463
54MP0002420_abnormal_adaptive_immunity1.29742524
55MP0010155_abnormal_intestine_physiology1.29629077
56MP0006082_CNS_inflammation1.29612174
57MP0005666_abnormal_adipose_tissue1.29103648
58MP0001819_abnormal_immune_cell1.28422738
59MP0005464_abnormal_platelet_physiology1.28292579
60MP0002254_reproductive_system_inflammat1.27712251
61MP0002396_abnormal_hematopoietic_system1.25918896
62MP0002796_impaired_skin_barrier1.24800325
63MP0001873_stomach_inflammation1.24503636
64MP0005025_abnormal_response_to1.24375990
65MP0002118_abnormal_lipid_homeostasis1.23299454
66MP0005451_abnormal_body_composition1.23117597
67MP0008057_abnormal_DNA_replication1.20294156
68MP0002419_abnormal_innate_immunity1.17261930
69MP0009785_altered_susceptibility_to1.16595917
70MP0004484_altered_response_of1.15335600
71MP0001845_abnormal_inflammatory_respons1.15157601
72MP0002398_abnormal_bone_marrow1.14960795
73MP0002877_abnormal_melanocyte_morpholog1.13663173
74MP0002933_joint_inflammation1.13273096
75MP0000015_abnormal_ear_pigmentation1.13092415
76MP0000604_amyloidosis1.10423604
77MP0008004_abnormal_stomach_pH1.10052770
78MP0002277_abnormal_respiratory_mucosa1.09780311
79MP0001853_heart_inflammation1.09754460
80MP0003724_increased_susceptibility_to1.08963550
81MP0002405_respiratory_system_inflammati1.08082461
82MP0005075_abnormal_melanosome_morpholog1.07950641
83MP0000716_abnormal_immune_system1.07730676
84MP0005670_abnormal_white_adipose1.07726845
85MP0003045_fibrosis1.07663373
86MP0008469_abnormal_protein_level1.07006978
87MP0000858_altered_metastatic_potential1.04217728
88MP0005319_abnormal_enzyme/_coenzyme1.04020305
89MP0003221_abnormal_cardiomyocyte_apopto1.03844635
90MP0003183_abnormal_peptide_metabolism1.01661337
91MP0005164_abnormal_response_to1.00511459
92MP0005023_abnormal_wound_healing0.99315100
93MP0005332_abnormal_amino_acid0.98358369
94MP0009763_increased_sensitivity_to0.98217958
95MP0003091_abnormal_cell_migration0.97692571
96MP0003868_abnormal_feces_composition0.97217235
97MP0000689_abnormal_spleen_morphology0.96458416
98MP0003690_abnormal_glial_cell0.96423391
99MP0009764_decreased_sensitivity_to0.95511738
100MP0002132_abnormal_respiratory_system0.95273494
101MP0001533_abnormal_skeleton_physiology0.93511480
102MP0002722_abnormal_immune_system0.93424306
103MP0002971_abnormal_brown_adipose0.91635323
104MP0002060_abnormal_skin_morphology0.90748851
105MP0005166_decreased_susceptibility_to0.90669535
106MP0005375_adipose_tissue_phenotype0.90560210
107MP0000598_abnormal_liver_morphology0.90516321
108MP0003656_abnormal_erythrocyte_physiolo0.89634055
109MP0005397_hematopoietic_system_phenotyp0.88097046
110MP0001545_abnormal_hematopoietic_system0.88097046
111MP0000703_abnormal_thymus_morphology0.87198133
112MP0001216_abnormal_epidermal_layer0.85777637
113MP0003787_abnormal_imprinting0.85711341
114MP0009643_abnormal_urine_homeostasis0.85045999
115MP0000465_gastrointestinal_hemorrhage0.84643662
116MP0002429_abnormal_blood_cell0.82562295
117MP0000249_abnormal_blood_vessel0.82473233
118MP0010678_abnormal_skin_adnexa0.79962868
119MP0010368_abnormal_lymphatic_system0.79876148
120MP0005584_abnormal_enzyme/coenzyme_acti0.79637935
121MP0002837_dystrophic_cardiac_calcinosis0.79597262
122MP0004808_abnormal_hematopoietic_stem0.79288624
123MP0005174_abnormal_tail_pigmentation0.78480323
124MP0002928_abnormal_bile_duct0.78224409
125MP0001663_abnormal_digestive_system0.78217247
126MP0010630_abnormal_cardiac_muscle0.78158316
127MP0003806_abnormal_nucleotide_metabolis0.78026953
128MP0002332_abnormal_exercise_endurance0.77938136
129MP0001986_abnormal_taste_sensitivity0.75780201
130MP0003448_altered_tumor_morphology0.74378541
131MP0003866_abnormal_defecation0.74234617
132MP0002168_other_aberrant_phenotype0.73486888
133MP0003075_altered_response_to0.73150862
134MP0002136_abnormal_kidney_physiology0.73149793
135MP0005390_skeleton_phenotype0.72981356
136MP0009115_abnormal_fat_cell0.63558423
137MP0003795_abnormal_bone_structure0.60725998
138MP0002133_abnormal_respiratory_system0.60464404
139MP0005388_respiratory_system_phenotype0.60464404
140MP0009765_abnormal_xenobiotic_induced0.57802673
141MP0006054_spinal_hemorrhage0.56882867

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.99740226
2Recurrent abscess formation (HP:0002722)4.65876191
3Optic neuritis (HP:0100653)4.41151624
4Retrobulbar optic neuritis (HP:0100654)4.41151624
5Deep venous thrombosis (HP:0002625)4.34512508
6Orchitis (HP:0100796)4.29865386
7Abnormality of macrophages (HP:0004311)3.81713274
8Chronic mucocutaneous candidiasis (HP:0002728)3.61666192
9Recurrent cutaneous fungal infections (HP:0011370)3.61666192
10Recurrent skin infections (HP:0001581)3.59863864
11Xanthomatosis (HP:0000991)3.55926962
12Mediastinal lymphadenopathy (HP:0100721)3.48800406
13Myocardial infarction (HP:0001658)3.45869074
14Complement deficiency (HP:0004431)3.42737054
15Keratoconjunctivitis sicca (HP:0001097)3.37378297
16Meningitis (HP:0001287)3.30860549
17Intrahepatic cholestasis (HP:0001406)3.27004762
18Encephalitis (HP:0002383)3.18878707
19Keratoconjunctivitis (HP:0001096)3.17327070
20Abnormality of monocarboxylic acid metabolism (HP:0010996)3.16986515
21Gingivitis (HP:0000230)3.02258058
22Leukocytosis (HP:0001974)3.01366999
23Panhypogammaglobulinemia (HP:0003139)3.00541439
24Hemoptysis (HP:0002105)2.98356195
25Pulmonary infiltrates (HP:0002113)2.95443989
26Prolonged bleeding time (HP:0003010)2.89850364
27Chest pain (HP:0100749)2.89435764
28Hyperlipoproteinemia (HP:0010980)2.84964033
29T lymphocytopenia (HP:0005403)2.82327977
30Increased IgE level (HP:0003212)2.81891036
31Abnormality of the common coagulation pathway (HP:0010990)2.81826065
32Papilledema (HP:0001085)2.80734529
33Abnormality of T cell number (HP:0011839)2.76583746
34Autoimmune hemolytic anemia (HP:0001890)2.75695580
35Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.75678857
36Obstructive lung disease (HP:0006536)2.71944177
37Chronic obstructive pulmonary disease (HP:0006510)2.71944177
38Abnormality of complement system (HP:0005339)2.71586729
39Abnormality of the fingertips (HP:0001211)2.71098283
40Epidermoid cyst (HP:0200040)2.67432773
41Hematochezia (HP:0002573)2.67294417
42Abnormality of aromatic amino acid family metabolism (HP:0004338)2.65047873
43Cerebral aneurysm (HP:0004944)2.59288542
44Eosinophilia (HP:0001880)2.57954499
45Urticaria (HP:0001025)2.54789255
46Eczematoid dermatitis (HP:0000976)2.53554896
47Granulocytopenia (HP:0001913)2.53438875
48Spontaneous hematomas (HP:0007420)2.50172392
49Stomach cancer (HP:0012126)2.49114502
50Hypoalphalipoproteinemia (HP:0003233)2.48299706
51Slow saccadic eye movements (HP:0000514)2.44950699
52Abnormality of eosinophils (HP:0001879)2.43981350
53Cellulitis (HP:0100658)2.41125755
54Autoimmune thrombocytopenia (HP:0001973)2.40088148
55Recurrent gram-negative bacterial infections (HP:0005420)2.38735538
56Esophageal varix (HP:0002040)2.37736503
57Right ventricular cardiomyopathy (HP:0011663)2.37638400
58Polycythemia (HP:0001901)2.36388013
59Mitral stenosis (HP:0001718)2.35383278
60Abnormality of glutamine family amino acid metabolism (HP:0010902)2.34594779
61Gangrene (HP:0100758)2.33662108
62Abnormality of T cell physiology (HP:0011840)2.33364137
63Hypobetalipoproteinemia (HP:0003563)2.32999989
64Aortic aneurysm (HP:0004942)2.31059832
65Pustule (HP:0200039)2.28598774
66Nasal polyposis (HP:0100582)2.28435271
67Prolonged partial thromboplastin time (HP:0003645)2.25774506
68Abnormality of the nasal mucosa (HP:0000433)2.25732469
69Joint hemorrhage (HP:0005261)2.24335278
70Episodic fever (HP:0001954)2.23811351
71Osteomyelitis (HP:0002754)2.23646103
72Mitral valve prolapse (HP:0001634)2.23005334
73Hypolipoproteinemia (HP:0010981)2.22542046
74Gingival bleeding (HP:0000225)2.21383214
75Ketosis (HP:0001946)2.21230289
76Pulmonary embolism (HP:0002204)2.21064509
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.20380296
78Papilloma (HP:0012740)2.19795527
79Verrucae (HP:0200043)2.19795527
80Lymphopenia (HP:0001888)2.19720860
81Systemic lupus erythematosus (HP:0002725)2.19564703
82Abnormal platelet volume (HP:0011876)2.19451197
83Severe combined immunodeficiency (HP:0004430)2.19321973
84Hypoglycemic coma (HP:0001325)2.17442248
85Increased mean platelet volume (HP:0011877)2.17039194
86Colitis (HP:0002583)2.16005830
87Hyperammonemia (HP:0001987)2.15716490
88Recurrent viral infections (HP:0004429)2.14602123
89Hyporeflexia of lower limbs (HP:0002600)2.14153320
90Chronic diarrhea (HP:0002028)2.13761020
91Hypercholesterolemia (HP:0003124)2.10731858
92Increased IgM level (HP:0003496)2.10487740
93Hepatocellular carcinoma (HP:0001402)2.10042650
94Neoplasm of the tracheobronchial system (HP:0100552)2.09498465
95Arterial thrombosis (HP:0004420)2.08856905
96Subacute progressive viral hepatitis (HP:0006572)2.08846894
97Gastrointestinal infarctions (HP:0005244)2.07349349
98Anorexia (HP:0002039)2.06698058
99Viral hepatitis (HP:0006562)2.06175784
100Abnormality of cells of the lymphoid lineage (HP:0012140)2.05058968
101Hypochromic anemia (HP:0001931)2.02374635
102Increased CSF protein (HP:0002922)2.01288140
103Hemorrhage of the eye (HP:0011885)2.01129770
104Abnormality of the pleura (HP:0002103)2.00782281
105Recurrent bronchitis (HP:0002837)1.99791825
106Striae distensae (HP:0001065)1.99047153
107Recurrent fungal infections (HP:0002841)1.98415229
108Hypochromic microcytic anemia (HP:0004840)1.97463679
109Abnormality of sulfur amino acid metabolism (HP:0004339)1.97393621
110Aneurysm (HP:0002617)1.97296656
111Thyroiditis (HP:0100646)1.97031331
112Agammaglobulinemia (HP:0004432)1.95321968
113Sepsis (HP:0100806)1.95000619
114Abnormality of the endocardium (HP:0004306)1.94925260
115Peritonitis (HP:0002586)1.94693294
116Inflammation of the large intestine (HP:0002037)1.93952436
117Hypergammaglobulinemia (HP:0010702)1.93187303
118Alveolar cell carcinoma (HP:0006519)1.92963112
119Spastic diplegia (HP:0001264)1.92843437
120Nephritis (HP:0000123)1.92657851
121Fat malabsorption (HP:0002630)1.91997905
122Thrombophlebitis (HP:0004418)1.91995149
123IgG deficiency (HP:0004315)1.90214742
124Frequent falls (HP:0002359)1.89459975
125Microcytic anemia (HP:0001935)1.87716602
126Periodontitis (HP:0000704)1.86281316
127Fatigue (HP:0012378)1.85652971
128Gastrointestinal inflammation (HP:0004386)1.84600435
129Macroorchidism (HP:0000053)1.82809268
130Hypoplasia of the thymus (HP:0000778)1.82804140
131Amaurosis fugax (HP:0100576)1.82200140
132Thin bony cortex (HP:0002753)1.80678316
133Skin nodule (HP:0200036)1.80369706
134Myositis (HP:0100614)1.80308534
135Abnormal delayed hypersensitivity skin test (HP:0002963)1.78532690
136Vertigo (HP:0002321)1.78397326
137Obstructive sleep apnea (HP:0002870)1.77831588
138Vasculitis (HP:0002633)1.77637756
139Keratitis (HP:0000491)1.76983993
140Abnormality of T cells (HP:0002843)1.76049668
141Acanthocytosis (HP:0001927)1.75260208
142Glomerulopathy (HP:0100820)1.75026726
143Joint swelling (HP:0001386)1.71208072
144Increased connective tissue (HP:0009025)1.70854337
145Disproportionate tall stature (HP:0001519)1.70607070
146Elevated erythrocyte sedimentation rate (HP:0003565)1.69616403
147Epistaxis (HP:0000421)1.68941242
148Osteolytic defects of the hand bones (HP:0009699)1.68814192
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.68814192
150Dilatation of the ascending aorta (HP:0005111)1.68710667
151Skin ulcer (HP:0200042)1.68031965
152Abnormality of the vasculature of the conjunctiva (HP:0008054)1.68016752
153Combined immunodeficiency (HP:0005387)1.66860640
154Polyneuropathy (HP:0001271)1.66748979
155Emphysema (HP:0002097)1.64739911
156Abnormality of the intrinsic pathway (HP:0010989)1.64539094
157Interstitial pulmonary disease (HP:0006530)1.64274236
158Increased density of long bones (HP:0006392)1.63569322
159Menorrhagia (HP:0000132)1.63394923
160Abnormality of the Achilles tendon (HP:0005109)1.63388242
161Ketoacidosis (HP:0001993)1.62604040
162Hydroxyprolinuria (HP:0003080)1.62441557
163Abnormality of proline metabolism (HP:0010907)1.62441557
164Glomerulonephritis (HP:0000099)1.61704407
165Stroke (HP:0001297)1.61297290
166Stomatitis (HP:0010280)1.60534097
167Back pain (HP:0003418)1.59270029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.40349355
2TRIB33.20854453
3FGFR42.98168404
4PKN22.80605530
5PRPF4B2.68297614
6MAP3K102.42785272
7EEF2K2.33926248
8FES2.27042265
9TYK22.26370824
10ITK2.14598586
11ERN12.08757188
12JAK12.08366534
13IRAK42.08179515
14SIK12.07304036
15TTN2.01285331
16STK101.99029455
17RIPK11.97304886
18TXK1.93943172
19PTK61.92506185
20GRK61.85720373
21FGFR31.81779587
22TGFBR21.75666450
23MAP3K141.69362672
24JAK31.68971320
25TAOK31.56545362
26IRAK11.51681478
27TBK11.50439689
28CAMKK21.44991698
29SIK31.44126260
30ZAP701.43044757
31CDK121.40676125
32MAP3K71.40590879
33EPHB11.38272379
34MAP3K131.34359015
35LATS11.33832436
36CSK1.33368622
37IKBKE1.32084524
38PIK3CG1.30962331
39TNK21.30726020
40JAK21.30051357
41MAP2K31.23024323
42LRRK21.22249790
43SGK21.22149507
44BMPR21.20447740
45CAMK1D1.16839917
46FGR1.16571079
47DMPK1.16536902
48LYN1.12986204
49IRAK21.10051832
50KIT1.09591339
51CDK61.09406264
52YES11.09261330
53MAPK71.06512510
54PRKCH1.04376460
55HCK1.03877522
56PDGFRA1.02352547
57FGFR21.01602148
58CHUK1.00199113
59MARK20.99725893
60EPHA30.96221879
61ACVR1B0.95741287
62MAP3K30.94590674
63CAMK1G0.94077975
64RET0.89652840
65PDGFRB0.89293938
66SIK20.89012182
67FRK0.88563338
68SGK30.86043045
69FLT30.84671471
70LCK0.83957158
71PRKCQ0.83487171
72BTK0.81777597
73STK240.80461929
74CAMKK10.80332461
75STK30.79911713
76TAOK10.78747321
77TEC0.74259110
78BRD40.73452346
79MAPK110.72397759
80MARK30.72223516
81SYK0.71473870
82PIM10.71374873
83PTK20.69434907
84CSF1R0.69311868
85IKBKB0.69251069
86MTOR0.68609281
87PDK10.66649810
88SGK2230.65667297
89SGK4940.65667297
90MAP3K20.65527430
91CAMK40.65317323
92PRKAA20.65268580
93MAP3K60.64322961
94TNIK0.63593891
95DYRK1B0.62276591
96HIPK20.61357304
97NLK0.61253745
98RIPK40.60471172
99BCKDK0.60432691
100BLK0.58594884
101STK110.58320677
102RPS6KA40.54999179
103NEK90.54927042
104GRK70.54042446
105MAPK120.53352007
106MELK0.53094390
107MST1R0.52910776
108PTK2B0.52852017
109NUAK10.52675504
110BMX0.52149940
111FGFR10.49710677
112TRPM70.48577164
113STK40.48245027
114PRKD10.48217565
115CDK40.47705804
116IRAK30.46927293
117TYRO30.46094300
118STK380.45897730
119MAP3K110.44936925
120KSR10.44935208
121CDC42BPA0.44828564
122PDPK10.44821112
123WNK10.44703359
124MATK0.44548655
125KSR20.44474715
126EGFR0.44147616
127FYN0.43102776
128CDK90.42944155
129GSK3A0.42493642
130PRKD20.41684711
131MAP3K10.40608411
132ALK0.40244853
133PRKAA10.39885067
134INSR0.38442542
135ICK0.37193728
136MAP3K50.36824421
137NEK60.35934753
138SGK10.35923183
139RPS6KC10.32324838

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.04298147
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.67240682
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.58971256
4Staphylococcus aureus infection_Homo sapiens_hsa051502.20118008
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.06535710
6Arginine biosynthesis_Homo sapiens_hsa002202.02811215
7Complement and coagulation cascades_Homo sapiens_hsa046101.93829297
8Fatty acid degradation_Homo sapiens_hsa000711.88834002
9Allograft rejection_Homo sapiens_hsa053301.84107847
10Autoimmune thyroid disease_Homo sapiens_hsa053201.70752748
11Caffeine metabolism_Homo sapiens_hsa002321.62621964
12PPAR signaling pathway_Homo sapiens_hsa033201.55620541
13Tryptophan metabolism_Homo sapiens_hsa003801.53043134
14Osteoclast differentiation_Homo sapiens_hsa043801.50286684
15T cell receptor signaling pathway_Homo sapiens_hsa046601.47280971
16ABC transporters_Homo sapiens_hsa020101.45025581
17Malaria_Homo sapiens_hsa051441.41800024
18Lysine degradation_Homo sapiens_hsa003101.41329944
19B cell receptor signaling pathway_Homo sapiens_hsa046621.41151540
20Insulin resistance_Homo sapiens_hsa049311.40009429
21Primary immunodeficiency_Homo sapiens_hsa053401.38282603
22Type I diabetes mellitus_Homo sapiens_hsa049401.32529346
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.26116953
24Legionellosis_Homo sapiens_hsa051341.22143430
25Bile secretion_Homo sapiens_hsa049761.21089898
26Fatty acid metabolism_Homo sapiens_hsa012121.20948861
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20465787
28Adipocytokine signaling pathway_Homo sapiens_hsa049201.19642665
29Leishmaniasis_Homo sapiens_hsa051401.18638386
30Toxoplasmosis_Homo sapiens_hsa051451.15432545
31Renal cell carcinoma_Homo sapiens_hsa052111.10641170
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10368050
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09954547
34Propanoate metabolism_Homo sapiens_hsa006401.08938902
35Herpes simplex infection_Homo sapiens_hsa051681.08898319
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04673023
37Measles_Homo sapiens_hsa051621.01707953
38Chronic myeloid leukemia_Homo sapiens_hsa052201.01678758
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99042571
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96701764
41Viral myocarditis_Homo sapiens_hsa054160.91703539
42TNF signaling pathway_Homo sapiens_hsa046680.89829287
43Acute myeloid leukemia_Homo sapiens_hsa052210.89157019
44Inositol phosphate metabolism_Homo sapiens_hsa005620.89139984
45Dorso-ventral axis formation_Homo sapiens_hsa043200.88584693
46Colorectal cancer_Homo sapiens_hsa052100.87450154
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.86480463
48Selenocompound metabolism_Homo sapiens_hsa004500.86273936
49Pancreatic cancer_Homo sapiens_hsa052120.86101507
50Butanoate metabolism_Homo sapiens_hsa006500.85737786
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85659020
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84936407
53Asthma_Homo sapiens_hsa053100.84775311
54Choline metabolism in cancer_Homo sapiens_hsa052310.84713991
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84050037
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.83459010
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.83435918
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.83072496
59mTOR signaling pathway_Homo sapiens_hsa041500.82295932
60GnRH signaling pathway_Homo sapiens_hsa049120.82099371
61Type II diabetes mellitus_Homo sapiens_hsa049300.80325450
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.79895997
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79641165
64African trypanosomiasis_Homo sapiens_hsa051430.79496088
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78598913
66Rheumatoid arthritis_Homo sapiens_hsa053230.78018384
67Peroxisome_Homo sapiens_hsa041460.77209282
68Chemical carcinogenesis_Homo sapiens_hsa052040.76617077
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75935340
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75874258
71Prostate cancer_Homo sapiens_hsa052150.75556280
72Starch and sucrose metabolism_Homo sapiens_hsa005000.75503399
73MAPK signaling pathway_Homo sapiens_hsa040100.73785525
74Small cell lung cancer_Homo sapiens_hsa052220.73468398
75Prolactin signaling pathway_Homo sapiens_hsa049170.72844315
76Phagosome_Homo sapiens_hsa041450.72520416
77Antigen processing and presentation_Homo sapiens_hsa046120.72354357
78Glycerolipid metabolism_Homo sapiens_hsa005610.70389243
79beta-Alanine metabolism_Homo sapiens_hsa004100.70163614
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69640495
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69336514
82Long-term potentiation_Homo sapiens_hsa047200.69286990
83ErbB signaling pathway_Homo sapiens_hsa040120.68718670
84Retinol metabolism_Homo sapiens_hsa008300.68582060
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67829729
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67441303
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67289847
88Hepatitis C_Homo sapiens_hsa051600.67268718
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67145663
90Amoebiasis_Homo sapiens_hsa051460.67110203
91Non-small cell lung cancer_Homo sapiens_hsa052230.67053800
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66751525
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66600565
94Fat digestion and absorption_Homo sapiens_hsa049750.66148923
95Sulfur metabolism_Homo sapiens_hsa009200.65105712
96Shigellosis_Homo sapiens_hsa051310.64646151
97Platelet activation_Homo sapiens_hsa046110.64488691
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64288223
99Influenza A_Homo sapiens_hsa051640.64212887
100Other glycan degradation_Homo sapiens_hsa005110.64023685
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63483222
102Graft-versus-host disease_Homo sapiens_hsa053320.63377909
103Histidine metabolism_Homo sapiens_hsa003400.62195675
104Glioma_Homo sapiens_hsa052140.61436381
105FoxO signaling pathway_Homo sapiens_hsa040680.61394279
106AMPK signaling pathway_Homo sapiens_hsa041520.61096553
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60830182
108Chemokine signaling pathway_Homo sapiens_hsa040620.60747756
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60728042
110Salmonella infection_Homo sapiens_hsa051320.60584002
111Adherens junction_Homo sapiens_hsa045200.60254288
112Notch signaling pathway_Homo sapiens_hsa043300.60243603
113Insulin signaling pathway_Homo sapiens_hsa049100.60054938
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60011616
115Hepatitis B_Homo sapiens_hsa051610.59802033
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59027809
117HIF-1 signaling pathway_Homo sapiens_hsa040660.59012934
118Viral carcinogenesis_Homo sapiens_hsa052030.59000432
119Regulation of autophagy_Homo sapiens_hsa041400.57500824
120Apoptosis_Homo sapiens_hsa042100.57350048
121Circadian rhythm_Homo sapiens_hsa047100.57279693
122VEGF signaling pathway_Homo sapiens_hsa043700.57160195
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57106205
124HTLV-I infection_Homo sapiens_hsa051660.56915625
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56561780
126Endocytosis_Homo sapiens_hsa041440.56293400
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56254564
128Phenylalanine metabolism_Homo sapiens_hsa003600.55410503
129Proteoglycans in cancer_Homo sapiens_hsa052050.54795236
130Hematopoietic cell lineage_Homo sapiens_hsa046400.54772736
131Focal adhesion_Homo sapiens_hsa045100.54372947
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53896977
133Glucagon signaling pathway_Homo sapiens_hsa049220.53725935
134Tuberculosis_Homo sapiens_hsa051520.53463696
135Pertussis_Homo sapiens_hsa051330.52916818
136Estrogen signaling pathway_Homo sapiens_hsa049150.52842968
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52726565
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52631069
139Epstein-Barr virus infection_Homo sapiens_hsa051690.52591386
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.52428162
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.51726205
142Endometrial cancer_Homo sapiens_hsa052130.50837812
143Ras signaling pathway_Homo sapiens_hsa040140.50384965
144Fatty acid biosynthesis_Homo sapiens_hsa000610.49321807
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49243533
146Renin secretion_Homo sapiens_hsa049240.47519528
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47060946

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