HEATR5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)4.52120361
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.43121433
3UDP-N-acetylglucosamine metabolic process (GO:0006047)3.89406877
4megakaryocyte development (GO:0035855)3.59477484
5nuclear pore organization (GO:0006999)3.40337734
6germ cell migration (GO:0008354)3.37785784
7regulation of hippo signaling (GO:0035330)3.36015252
8positive regulation by symbiont of host defense response (GO:0052509)3.35527280
9modulation by symbiont of host defense response (GO:0052031)3.35527280
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.35527280
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.35527280
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.35527280
13modulation by symbiont of host immune response (GO:0052553)3.35527280
14negative regulation of complement activation (GO:0045916)3.35107670
15negative regulation of protein activation cascade (GO:2000258)3.33620876
16regulation of interferon-beta biosynthetic process (GO:0045357)3.15903878
17sequestering of extracellular ligand from receptor (GO:0035581)3.14775372
18nuclear pore complex assembly (GO:0051292)3.14077705
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.11181676
20glomerular visceral epithelial cell development (GO:0072015)3.08013546
21cell morphogenesis involved in neuron differentiation (GO:0048667)3.03372107
22blood vessel maturation (GO:0001955)2.99381310
23regulation of integrin activation (GO:0033623)2.98805482
24negative regulation of granulocyte differentiation (GO:0030853)2.96819691
25COPII vesicle coating (GO:0048208)2.96126894
26positive regulation of cardiac muscle hypertrophy (GO:0010613)2.95390811
27positive regulation of muscle hypertrophy (GO:0014742)2.95390811
28pinocytosis (GO:0006907)2.93433380
29cell adhesion mediated by integrin (GO:0033627)2.93234884
30regulation of sarcomere organization (GO:0060297)2.92224378
31glomerular basement membrane development (GO:0032836)2.86536694
32DNA unwinding involved in DNA replication (GO:0006268)2.84924447
33positive regulation of interferon-alpha production (GO:0032727)2.83993535
34apoptotic cell clearance (GO:0043277)2.81535576
35production of molecular mediator involved in inflammatory response (GO:0002532)2.80556142
36pericardium development (GO:0060039)2.80212887
37glomerular epithelial cell development (GO:0072310)2.79909732
38lymphangiogenesis (GO:0001946)2.77210367
39urate metabolic process (GO:0046415)2.77097636
40chondrocyte proliferation (GO:0035988)2.74997798
41positive regulation of glycolytic process (GO:0045821)2.72641115
42mesenchymal-epithelial cell signaling (GO:0060638)2.69902166
43retina vasculature morphogenesis in camera-type eye (GO:0061299)2.68274024
44fatty acid transmembrane transport (GO:1902001)2.65673837
45regulation of interferon-alpha production (GO:0032647)2.65132977
46IMP biosynthetic process (GO:0006188)2.63804493
47positive regulation of cardiac muscle cell differentiation (GO:2000727)2.61177248
48carnitine shuttle (GO:0006853)2.59530064
49monoubiquitinated protein deubiquitination (GO:0035520)2.59130315
50IMP metabolic process (GO:0046040)2.58978898
51response to UV-C (GO:0010225)2.58364974
52cilium or flagellum-dependent cell motility (GO:0001539)2.57986417
53positive regulation of SMAD protein import into nucleus (GO:0060391)2.53140886
54regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.50917381
55positive regulation of histone deacetylation (GO:0031065)2.50446762
56epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.49026967
57interkinetic nuclear migration (GO:0022027)2.48878796
58hepatocyte apoptotic process (GO:0097284)2.48501558
59iron ion import (GO:0097286)2.47645243
60endodermal cell differentiation (GO:0035987)2.47090814
61embryonic foregut morphogenesis (GO:0048617)2.46189891
62mRNA transcription (GO:0009299)2.46176230
63regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.45291079
64response to interferon-alpha (GO:0035455)2.43968531
65regulation of integrin-mediated signaling pathway (GO:2001044)2.42862612
66nephron epithelium morphogenesis (GO:0072088)2.41951970
67nephron tubule morphogenesis (GO:0072078)2.41951970
68embryonic hemopoiesis (GO:0035162)2.41786629
69negative regulation of phagocytosis (GO:0050765)2.40640054
70phagocytosis, engulfment (GO:0006911)2.39334764
71regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.39268218
72pore complex assembly (GO:0046931)2.38941024
73cortical actin cytoskeleton organization (GO:0030866)2.37832441
74paraxial mesoderm development (GO:0048339)2.36925619
75embryonic process involved in female pregnancy (GO:0060136)2.36291962
76very-low-density lipoprotein particle assembly (GO:0034379)2.35905342
77positive regulation of gamma-delta T cell activation (GO:0046645)2.35581781
78antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.35409950
79antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.35409950
80biotin metabolic process (GO:0006768)2.34786398
81cilium movement (GO:0003341)2.34614401
82negative regulation of leukocyte chemotaxis (GO:0002689)2.34359335
83dermatan sulfate metabolic process (GO:0030205)2.34004719
84interleukin-6-mediated signaling pathway (GO:0070102)2.32909379
85regulation of SMAD protein import into nucleus (GO:0060390)2.32769751
86regulation of non-canonical Wnt signaling pathway (GO:2000050)2.32681328
87integrin-mediated signaling pathway (GO:0007229)2.32310531
88amino-acid betaine transport (GO:0015838)2.31901959
89carnitine transport (GO:0015879)2.31901959
90positive regulation of B cell differentiation (GO:0045579)2.31496866
91regulation of cardiac muscle hypertrophy (GO:0010611)2.31322005
92axonemal dynein complex assembly (GO:0070286)2.30607883
93regulation of muscle hypertrophy (GO:0014743)2.30100409
94positive regulation of interferon-beta production (GO:0032728)2.29041317
95cardiac myofibril assembly (GO:0055003)2.28708997
96response to laminar fluid shear stress (GO:0034616)2.28499653
97epithelial cell-cell adhesion (GO:0090136)2.28016759
98negative regulation of axon extension involved in axon guidance (GO:0048843)2.27995317
99protein localization to kinetochore (GO:0034501)2.27351123
100negative regulation of B cell proliferation (GO:0030889)2.26905436
101regulation of phospholipase A2 activity (GO:0032429)2.26703512
102mitotic sister chromatid cohesion (GO:0007064)2.26600396
103carnitine transmembrane transport (GO:1902603)2.26060879
104histone-serine phosphorylation (GO:0035404)2.24846656
105endocardial cushion development (GO:0003197)2.24416811
106notochord development (GO:0030903)2.23931565
107mRNA transcription from RNA polymerase II promoter (GO:0042789)2.23478967
108positive regulation of protein deacetylation (GO:0090312)2.23209957
109regulation of protein polyubiquitination (GO:1902914)2.23037348
110dermatan sulfate biosynthetic process (GO:0030208)2.22108746
111wound healing, spreading of epidermal cells (GO:0035313)2.22042170
112import into cell (GO:0098657)2.21548739
113mannose metabolic process (GO:0006013)2.21532444
114cellular zinc ion homeostasis (GO:0006882)2.21400048
115glycoprotein catabolic process (GO:0006516)2.20794810
116glucocorticoid receptor signaling pathway (GO:0042921)2.20673553
117regulation of spindle organization (GO:0090224)2.20429651
118viral entry into host cell (GO:0046718)2.18950585
119regulation of interleukin-12 biosynthetic process (GO:0045075)2.18190989
120macrophage activation involved in immune response (GO:0002281)2.18141989
121negative regulation of stress fiber assembly (GO:0051497)2.17992328
122RNA stabilization (GO:0043489)2.17764310
123mRNA stabilization (GO:0048255)2.17764310
124positive regulation of protein import into nucleus, translocation (GO:0033160)2.17635442
125negative regulation of protein localization to cell surface (GO:2000009)2.17125772
126phospholipid homeostasis (GO:0055091)2.16384124
127regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.16024033
128vascular smooth muscle contraction (GO:0014829)2.15018500
129type B pancreatic cell proliferation (GO:0044342)2.13350561
130renal tubule morphogenesis (GO:0061333)2.13283716
131myeloid cell development (GO:0061515)2.13276230
132hyaluronan catabolic process (GO:0030214)2.12697686
133morphogenesis of an epithelial sheet (GO:0002011)2.12524094
134folic acid-containing compound biosynthetic process (GO:0009396)2.12329782
135negative regulation of erythrocyte differentiation (GO:0045647)2.11529674
136regulation of cardiac muscle cell differentiation (GO:2000725)2.11421342
137vascular endothelial growth factor signaling pathway (GO:0038084)2.11294671
138intracellular lipid transport (GO:0032365)2.11275309
139regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.10956410
140dosage compensation (GO:0007549)2.10834669
141drug transmembrane transport (GO:0006855)2.10583440
142negative regulation of humoral immune response (GO:0002921)2.09927416
143dorsal/ventral axis specification (GO:0009950)2.09883980
144anterior/posterior axis specification, embryo (GO:0008595)2.09755068
145regulation of chemokine-mediated signaling pathway (GO:0070099)2.09673153
146positive regulation of osteoblast proliferation (GO:0033690)2.09133893
147protein localization to cell surface (GO:0034394)2.08790412
148mesodermal cell differentiation (GO:0048333)2.08623476
149response to fluid shear stress (GO:0034405)2.08171210
150retinal metabolic process (GO:0042574)2.07810516
151keratan sulfate catabolic process (GO:0042340)2.07798075
152plasma membrane repair (GO:0001778)2.06696014
153translesion synthesis (GO:0019985)2.06324753
154Arp2/3 complex-mediated actin nucleation (GO:0034314)2.05806507
155negative chemotaxis (GO:0050919)2.05453254
156positive regulation of natural killer cell differentiation (GO:0032825)2.05280389
157cysteine metabolic process (GO:0006534)2.04764047
1583-UTR-mediated mRNA stabilization (GO:0070935)2.04656254
159photoreceptor cell differentiation (GO:0046530)2.04467327
160eye photoreceptor cell differentiation (GO:0001754)2.04467327
161substrate adhesion-dependent cell spreading (GO:0034446)2.04031672
162endothelial cell morphogenesis (GO:0001886)2.03978742
163myofibril assembly (GO:0030239)2.03093155
164immunoglobulin mediated immune response (GO:0016064)2.03091245
165cellular response to thyroid hormone stimulus (GO:0097067)2.02793377
166nucleotide-sugar metabolic process (GO:0009225)2.02643327
167epithelial cilium movement (GO:0003351)2.02388466
168negative regulation of axon guidance (GO:1902668)2.02297930
169negative regulation of chondrocyte differentiation (GO:0032331)2.02067831
170chondrocyte development (GO:0002063)2.02037475
171regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.01821291
172cartilage morphogenesis (GO:0060536)2.01793370
173regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.01791879
174regulation of erythrocyte differentiation (GO:0045646)2.01650417
175intestinal cholesterol absorption (GO:0030299)2.01402678
176barbed-end actin filament capping (GO:0051016)2.00903337
177response to muramyl dipeptide (GO:0032495)2.00811499
178response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.00290903
179response to host immune response (GO:0052572)2.00290903
180positive regulation of blood vessel endothelial cell migration (GO:0043536)2.00193682
181macroautophagy (GO:0016236)1.98907779
182nucleus localization (GO:0051647)1.98512871
183I-kappaB phosphorylation (GO:0007252)1.98503755
184collagen fibril organization (GO:0030199)1.98108798
185thrombin receptor signaling pathway (GO:0070493)1.97903285
186regulation of necroptotic process (GO:0060544)1.97871774
187B cell homeostasis (GO:0001782)1.97215365
188neutrophil activation involved in immune response (GO:0002283)1.96460389
189response to host defenses (GO:0052200)1.95043324
190response to defenses of other organism involved in symbiotic interaction (GO:0052173)1.95043324
191response to host (GO:0075136)1.95043324
192positive regulation of chemokine secretion (GO:0090197)1.94787866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.60966139
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.91052234
3GBX2_23144817_ChIP-Seq_PC3_Human3.16178792
4SCL_19346495_ChIP-Seq_HPC-7_Human3.08569594
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.00711417
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.99527999
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.91250131
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.87761073
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.66085189
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63116936
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.53693397
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53261076
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.47940409
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36628519
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34504589
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32776804
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.27049153
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25673632
19GATA1_22025678_ChIP-Seq_K562_Human2.22270259
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.20275725
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.17521179
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16274537
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16225482
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.13083390
25NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.06493959
26NRF2_20460467_ChIP-Seq_MEFs_Mouse2.06493959
27PIAS1_25552417_ChIP-Seq_VCAP_Human2.04320250
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02524299
29FLI1_27457419_Chip-Seq_LIVER_Mouse2.02471901
30CJUN_26792858_Chip-Seq_BT549_Human2.00796285
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.97938242
32MYC_22102868_ChIP-Seq_BL_Human1.94362744
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93856391
34FUS_26573619_Chip-Seq_HEK293_Human1.89422081
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.86941174
36P300_19829295_ChIP-Seq_ESCs_Human1.84818942
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84431492
38SMAD4_21799915_ChIP-Seq_A2780_Human1.81971560
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.81553234
40TP53_16413492_ChIP-PET_HCT116_Human1.81286092
41EWS_26573619_Chip-Seq_HEK293_Human1.80552193
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.80014021
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79978669
44* ZNF274_21170338_ChIP-Seq_K562_Hela1.78634777
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77848297
46SPI1_23547873_ChIP-Seq_NB4_Human1.76369393
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76330743
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76313719
49TCF7_22412390_ChIP-Seq_EML_Mouse1.75604108
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74154716
51TAF15_26573619_Chip-Seq_HEK293_Human1.70407969
52FOXM1_26456572_ChIP-Seq_MCF-7_Human1.69258903
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68949074
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.68748926
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.68303541
56VDR_21846776_ChIP-Seq_THP-1_Human1.67835511
57AHR_22903824_ChIP-Seq_MCF-7_Human1.65639084
58VDR_22108803_ChIP-Seq_LS180_Human1.64064402
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.64026797
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63714144
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62517626
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61855581
63STAT3_23295773_ChIP-Seq_U87_Human1.61787957
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.60079492
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59961124
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59076533
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59039041
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.58709539
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57999479
70SPI1_23127762_ChIP-Seq_K562_Human1.57792165
71MYB_26560356_Chip-Seq_TH1_Human1.57640987
72VDR_24763502_ChIP-Seq_THP-1_Human1.57262252
73MYB_26560356_Chip-Seq_TH2_Human1.55666046
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55438700
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54677152
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.53489480
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53005314
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.52613736
79RUNX_20019798_ChIP-Seq_JUKART_Human1.51864026
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49331722
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.48878055
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47709487
83TP53_18474530_ChIP-ChIP_U2OS_Human1.45869958
84* CDX2_22108803_ChIP-Seq_LS180_Human1.45156173
85AR_21909140_ChIP-Seq_LNCAP_Human1.44799747
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.44721663
87BCAT_22108803_ChIP-Seq_LS180_Human1.44443578
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44271837
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44204092
90ER_23166858_ChIP-Seq_MCF-7_Human1.44033316
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43946368
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42380195
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41739225
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41108892
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.41105348
96FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40878708
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39768366
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.38798241
99BP1_19119308_ChIP-ChIP_Hs578T_Human1.38257025
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37874669
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37644938
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37574725
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37574725
104TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37229627
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37131446
106CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36736725
107MAF_26560356_Chip-Seq_TH1_Human1.35352410
108PU_27001747_Chip-Seq_BMDM_Mouse1.35141310
109AR_21572438_ChIP-Seq_LNCaP_Human1.34288718
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.34240948
111* TCF4_23295773_ChIP-Seq_U87_Human1.34180045
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33842830
113RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33815515
114CLOCK_20551151_ChIP-Seq_293T_Human1.33754226
115FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30450152
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29402388
117SALL1_21062744_ChIP-ChIP_HESCs_Human1.29369100
118TCF4_18268006_ChIP-ChIP_LS174T_Human1.29158865
119TCF4_22108803_ChIP-Seq_LS180_Human1.28583919
120TFEB_21752829_ChIP-Seq_HELA_Human1.28410762
121BRD4_25478319_ChIP-Seq_HGPS_Human1.27687761
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26917956
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26716505
124IGF1R_20145208_ChIP-Seq_DFB_Human1.26423091
125UTX_26944678_Chip-Seq_JUKART_Human1.25860485
126HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25848318
127ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25325238
128RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24954406
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24610896
130GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24504500
131TP63_23658742_ChIP-Seq_EP156T_Human1.24156530
132EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23812762
133KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23461231
134SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23427374
135NFE2_27457419_Chip-Seq_LIVER_Mouse1.23073431
136PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22645638
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22405731
138AR_25329375_ChIP-Seq_VCAP_Human1.21575921
139KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20760369
140TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20349778
141GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19948832
142RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19086810
143NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18992635
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18105060
145CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17780810
146FOXO3_23340844_ChIP-Seq_DLD1_Human1.17216919
147STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15696401
148* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15656805
149TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15604805
150TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15377881
151E2F1_18555785_Chip-Seq_ESCs_Mouse1.15232868
152NCOR1_26117541_ChIP-Seq_K562_Human1.14297208
153FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10590398
154P53_22387025_ChIP-Seq_ESCs_Mouse1.10484639
155RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09911482
156* RUNX2_22187159_ChIP-Seq_PCA_Human1.09367543
157SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09158732
158ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08986120
159NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08950430
160CRX_20693478_ChIP-Seq_RETINA_Mouse1.08758107
161TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07751105
162IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07532554
163CBP_20019798_ChIP-Seq_JUKART_Human1.07532554
164LXR_22158963_ChIP-Seq_LIVER_Mouse1.07509412
165CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07317531
166TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07067065
167CMYC_18555785_Chip-Seq_ESCs_Mouse1.06532325
168FOXA2_19822575_ChIP-Seq_HepG2_Human1.05323005
169SMAD3_21741376_ChIP-Seq_HESCs_Human1.04975954
170CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04926901
171PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04319093
172STAT3_18555785_Chip-Seq_ESCs_Mouse1.04086665
173SMAD4_21741376_ChIP-Seq_EPCs_Human1.03271162
174KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02757620
175WT1_19549856_ChIP-ChIP_CCG9911_Human1.02012235
176GATA6_25053715_ChIP-Seq_YYC3_Human1.01598018
177ESR1_21235772_ChIP-Seq_MCF-7_Human1.00358920
178GATA1_19941826_ChIP-Seq_K562_Human0.98314522
179STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96871002
180KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96439160
181GATA1_19941827_ChIP-Seq_MEL_Mouse0.95379258
182MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95373260
183EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.93132894
184KDM2B_26808549_Chip-Seq_DND41_Human0.92988357
185GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92565676
186NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92080825
187NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91904076
188P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90491765
189HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89676914
190GATA2_19941826_ChIP-Seq_K562_Human0.89291135
191MYC_18555785_ChIP-Seq_MESCs_Mouse0.88515722
192ATF3_27146783_Chip-Seq_COLON_Human0.87588998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.34210318
2MP0005171_absent_coat_pigmentation2.82082102
3MP0003705_abnormal_hypodermis_morpholog2.52791704
4MP0009780_abnormal_chondrocyte_physiolo2.52457538
5MP0000569_abnormal_digit_pigmentation2.51308853
6MP0002877_abnormal_melanocyte_morpholog2.51110551
7MP0002396_abnormal_hematopoietic_system2.42644398
8MP0003279_aneurysm2.35520680
9MP0005408_hypopigmentation2.29285631
10MP0006054_spinal_hemorrhage2.27156859
11MP0003136_yellow_coat_color2.25990262
12MP0010352_gastrointestinal_tract_polyps2.23275400
13MP0004808_abnormal_hematopoietic_stem2.17182148
14MP0003566_abnormal_cell_adhesion2.13816521
15MP0000013_abnormal_adipose_tissue2.06419363
16MP0009278_abnormal_bone_marrow2.03097194
17MP0003300_gastrointestinal_ulcer2.02308341
18MP0002837_dystrophic_cardiac_calcinosis2.01063434
19MP0001958_emphysema1.97778755
20MP0003941_abnormal_skin_development1.94493286
21MP0005058_abnormal_lysosome_morphology1.91888284
22MP0003195_calcinosis1.82439391
23MP0005174_abnormal_tail_pigmentation1.73983123
24MP0002166_altered_tumor_susceptibility1.69917508
25MP0001545_abnormal_hematopoietic_system1.68018863
26MP0005397_hematopoietic_system_phenotyp1.68018863
27MP0005464_abnormal_platelet_physiology1.67209659
28MP0010307_abnormal_tumor_latency1.66574233
29MP0003937_abnormal_limbs/digits/tail_de1.61097704
30MP0000465_gastrointestinal_hemorrhage1.53958157
31MP0004147_increased_porphyrin_level1.53209552
32MP0005023_abnormal_wound_healing1.48111974
33MP0005085_abnormal_gallbladder_physiolo1.45390141
34MP0001835_abnormal_antigen_presentation1.44232906
35MP0001915_intracranial_hemorrhage1.43894218
36MP0003252_abnormal_bile_duct1.43821078
37MP0005275_abnormal_skin_tensile1.43596935
38MP0003436_decreased_susceptibility_to1.41382109
39MP0004036_abnormal_muscle_relaxation1.38187266
40MP0002938_white_spotting1.37018388
41MP0001299_abnormal_eye_distance/1.36142296
42MP0002295_abnormal_pulmonary_circulatio1.35533799
43MP0000767_abnormal_smooth_muscle1.34680415
44MP0009250_abnormal_appendicular_skeleto1.32518748
45MP0002419_abnormal_innate_immunity1.31456195
46MP0000749_muscle_degeneration1.30491156
47MP0000733_abnormal_muscle_development1.26665771
48MP0008775_abnormal_heart_ventricle1.24750931
49MP0008007_abnormal_cellular_replicative1.23925016
50MP0000427_abnormal_hair_cycle1.23447347
51MP0002006_tumorigenesis1.23211238
52MP0003091_abnormal_cell_migration1.21333178
53MP0002452_abnormal_antigen_presenting1.19095097
54MP0010094_abnormal_chromosome_stability1.18177482
55MP0004215_abnormal_myocardial_fiber1.17434120
56MP0002896_abnormal_bone_mineralization1.17224806
57MP0000490_abnormal_crypts_of1.16677224
58MP0003183_abnormal_peptide_metabolism1.16393395
59MP0003806_abnormal_nucleotide_metabolis1.15972436
60MP0010678_abnormal_skin_adnexa1.15603432
61MP0002254_reproductive_system_inflammat1.14027071
62MP0002108_abnormal_muscle_morphology1.13305244
63MP0003828_pulmonary_edema1.13073531
64MP0004233_abnormal_muscle_weight1.12658225
65MP0001533_abnormal_skeleton_physiology1.12107342
66MP0003868_abnormal_feces_composition1.11625187
67MP0010386_abnormal_urinary_bladder1.10403571
68MP0010329_abnormal_lipoprotein_level1.10113701
69MP0002009_preneoplasia1.09453722
70MP0000383_abnormal_hair_follicle1.09270480
71MP0005503_abnormal_tendon_morphology1.08505496
72MP0002282_abnormal_trachea_morphology1.07439310
73MP0002269_muscular_atrophy1.06123099
74MP0002398_abnormal_bone_marrow1.05130678
75MP0002933_joint_inflammation1.03603772
76MP0005365_abnormal_bile_salt1.03508171
77MP0000343_altered_response_to1.03431297
78MP0004272_abnormal_basement_membrane1.02858626
79MP0005076_abnormal_cell_differentiation1.02081129
80MP0005409_darkened_coat_color1.01974266
81MP0003950_abnormal_plasma_membrane1.01972437
82MP0010368_abnormal_lymphatic_system1.01912173
83MP0000689_abnormal_spleen_morphology0.99921778
84MP0006138_congestive_heart_failure0.99867064
85MP0001800_abnormal_humoral_immune0.99433960
86MP0005257_abnormal_intraocular_pressure0.99356136
87MP0003077_abnormal_cell_cycle0.99019656
88MP0004947_skin_inflammation0.98819244
89MP0003448_altered_tumor_morphology0.98638885
90MP0010155_abnormal_intestine_physiology0.98231222
91MP0003724_increased_susceptibility_to0.97274409
92MP0005025_abnormal_response_to0.97217732
93MP0008057_abnormal_DNA_replication0.97178713
94MP0002086_abnormal_extraembryonic_tissu0.96530831
95MP0001819_abnormal_immune_cell0.96138978
96MP0002420_abnormal_adaptive_immunity0.95741308
97MP0003943_abnormal_hepatobiliary_system0.95436511
98MP0001661_extended_life_span0.95176557
99MP0009697_abnormal_copulation0.94938827
100MP0002095_abnormal_skin_pigmentation0.92801965
101MP0010234_abnormal_vibrissa_follicle0.92373508
102MP0000858_altered_metastatic_potential0.92202057
103MP0010630_abnormal_cardiac_muscle0.92182871
104MP0002060_abnormal_skin_morphology0.91250300
105MP0002128_abnormal_blood_circulation0.91197230
106MP0009333_abnormal_splenocyte_physiolog0.91136173
107MP0002925_abnormal_cardiovascular_devel0.91129758
108MP0005000_abnormal_immune_tolerance0.90741817
109MP0005623_abnormal_meninges_morphology0.90652674
110MP0002722_abnormal_immune_system0.90253380
111MP0003567_abnormal_fetal_cardiomyocyte0.90161074
112MP0001243_abnormal_dermal_layer0.90072311
113MP0003172_abnormal_lysosome_physiology0.89730201
114MP0002723_abnormal_immune_serum0.89643183
115MP0002405_respiratory_system_inflammati0.89247684
116MP0001614_abnormal_blood_vessel0.89035984
117MP0005670_abnormal_white_adipose0.89034068
118MP0002998_abnormal_bone_remodeling0.88250109
119MP0003111_abnormal_nucleus_morphology0.87913805
120MP0009384_cardiac_valve_regurgitation0.87880402
121MP0003283_abnormal_digestive_organ0.87660012
122MP0004134_abnormal_chest_morphology0.87553165
123MP0005671_abnormal_response_to0.87370065
124MP0009840_abnormal_foam_cell0.87218227
125MP0006082_CNS_inflammation0.86344336
126MP0000428_abnormal_craniofacial_morphol0.86140903
127MP0001873_stomach_inflammation0.86050172
128MP0002429_abnormal_blood_cell0.85027536
129MP0002168_other_aberrant_phenotype0.84815695
130MP0003984_embryonic_growth_retardation0.84788366
131MP0003755_abnormal_palate_morphology0.84395411
132MP0000716_abnormal_immune_system0.84327111
133MP0005084_abnormal_gallbladder_morpholo0.83169379
134MP0005390_skeleton_phenotype0.83005984
135MP0002088_abnormal_embryonic_growth/wei0.82304617
136MP0008875_abnormal_xenobiotic_pharmacok0.81931508
137MP0005595_abnormal_vascular_smooth0.81845655
138MP0000015_abnormal_ear_pigmentation0.81621905
139MP0000371_diluted_coat_color0.80352474
140MP0000762_abnormal_tongue_morphology0.79654756
141MP0004484_altered_response_of0.79073734
142MP0001324_abnormal_eye_pigmentation0.79032005
143MP0000685_abnormal_immune_system0.78920954
144MP0002075_abnormal_coat/hair_pigmentati0.78369820
145MP0004084_abnormal_cardiac_muscle0.77396578
146MP0005620_abnormal_muscle_contractility0.77324823
147MP0000372_irregular_coat_pigmentation0.76405285
148MP0000249_abnormal_blood_vessel0.76069416
149MP0001790_abnormal_immune_system0.75069891
150MP0005387_immune_system_phenotype0.75069891
151MP0005332_abnormal_amino_acid0.74848728
152MP0002115_abnormal_skeleton_extremities0.74819268
153MP0003935_abnormal_craniofacial_develop0.74808320
154MP0001879_abnormal_lymphatic_vessel0.73925449
155MP0002876_abnormal_thyroid_physiology0.73659909
156MP0005508_abnormal_skeleton_morphology0.72827597
157MP0000538_abnormal_urinary_bladder0.72502301
158MP0002160_abnormal_reproductive_system0.72089763
159MP0005360_urolithiasis0.71311602
160MP0002697_abnormal_eye_size0.70646512
161MP0003632_abnormal_nervous_system0.68706197
162MP0000163_abnormal_cartilage_morphology0.68431733
163MP0002092_abnormal_eye_morphology0.67250464
164MP0005551_abnormal_eye_electrophysiolog0.67199749
165MP0005197_abnormal_uvea_morphology0.66547345
166MP0000647_abnormal_sebaceous_gland0.66466008
167MP0000747_muscle_weakness0.65557517
168MP0001186_pigmentation_phenotype0.65427868
169MP0005164_abnormal_response_to0.65330907
170MP0005395_other_phenotype0.65246827
171MP0000534_abnormal_ureter_morphology0.65112869

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.57327381
2Premature rupture of membranes (HP:0001788)3.55018742
3Syringomyelia (HP:0003396)3.39344669
4Spinal cord lesions (HP:0100561)3.39344669
5Cerebral aneurysm (HP:0004944)3.35416965
6Aortic aneurysm (HP:0004942)3.26958574
7Mitral stenosis (HP:0001718)3.20985060
8Aortic dissection (HP:0002647)3.17159744
9Osteolytic defects of the hand bones (HP:0009699)3.15508336
10Osteolytic defects of the phalanges of the hand (HP:0009771)3.15508336
11Tubular atrophy (HP:0000092)3.10852682
12Cervical subluxation (HP:0003308)3.06682139
13Cardiovascular calcification (HP:0011915)2.98249421
14Cutaneous melanoma (HP:0012056)2.85809491
15Abnormal platelet volume (HP:0011876)2.73834471
16Ankle contracture (HP:0006466)2.70900079
17Increased mean platelet volume (HP:0011877)2.63885647
18Increased cerebral lipofuscin (HP:0011813)2.58431371
19Neonatal short-limb short stature (HP:0008921)2.55123198
20Hypobetalipoproteinemia (HP:0003563)2.53916541
21Increased corneal curvature (HP:0100692)2.50576117
22Keratoconus (HP:0000563)2.50576117
23Bell-shaped thorax (HP:0001591)2.49168601
24Absent frontal sinuses (HP:0002688)2.49042072
25Peritonitis (HP:0002586)2.47998542
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.47725300
27Distal lower limb amyotrophy (HP:0008944)2.46563823
28Vacuolated lymphocytes (HP:0001922)2.42107853
29Increased connective tissue (HP:0009025)2.41892307
30Hydroxyprolinuria (HP:0003080)2.37570108
31Abnormality of proline metabolism (HP:0010907)2.37570108
32Vascular calcification (HP:0004934)2.36182554
33Abnormality of the intrinsic pathway (HP:0010989)2.34487325
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.34156540
35Facial diplegia (HP:0001349)2.33314794
36Hematochezia (HP:0002573)2.33209386
37Abnormality of the ischium (HP:0003174)2.29539634
38Bladder diverticulum (HP:0000015)2.28910127
39Soft skin (HP:0000977)2.28819744
40Disinhibition (HP:0000734)2.27337597
41Short 4th metacarpal (HP:0010044)2.27301801
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.27301801
43Abnormality of midbrain morphology (HP:0002418)2.25691122
44Molar tooth sign on MRI (HP:0002419)2.25691122
45Pheochromocytoma (HP:0002666)2.25503092
46Asymmetry of the thorax (HP:0001555)2.25306261
47Neuroendocrine neoplasm (HP:0100634)2.24736945
48Ovoid vertebral bodies (HP:0003300)2.23582224
49Thrombocytosis (HP:0001894)2.22904813
50Recurrent abscess formation (HP:0002722)2.22815133
51Recurrent viral infections (HP:0004429)2.22462014
52Shallow orbits (HP:0000586)2.20517532
53Abnormality of the renal cortex (HP:0011035)2.18449417
54Acute myeloid leukemia (HP:0004808)2.17935981
55Spontaneous hematomas (HP:0007420)2.17515681
56Dilatation of the ascending aorta (HP:0005111)2.16681581
57Broad metatarsal (HP:0001783)2.16147758
58Abnormal biliary tract morphology (HP:0012440)2.14512921
59Abnormality of dentin (HP:0010299)2.13862579
60Atrophic scars (HP:0001075)2.13722644
61Spondylolisthesis (HP:0003302)2.13118869
62Abnormal ciliary motility (HP:0012262)2.12843535
63Follicular hyperkeratosis (HP:0007502)2.12491079
64Flared iliac wings (HP:0002869)2.11408716
65Vertebral compression fractures (HP:0002953)2.10138691
66Flat acetabular roof (HP:0003180)2.09996638
67Prolonged bleeding time (HP:0003010)2.09256016
68Aortic regurgitation (HP:0001659)2.08667678
69Abnormality of the fingertips (HP:0001211)2.07386481
70Hypolipoproteinemia (HP:0010981)2.07171033
71Mitral valve prolapse (HP:0001634)2.05973293
72Coronal craniosynostosis (HP:0004440)2.05960525
73Autoimmune thrombocytopenia (HP:0001973)2.05260103
74Wormian bones (HP:0002645)2.05228411
75Recurrent bacterial skin infections (HP:0005406)2.04902140
76Chronic hepatic failure (HP:0100626)2.04576001
77Impaired platelet aggregation (HP:0003540)2.04474309
78Abnormal platelet function (HP:0011869)2.04474309
79Cerebellar dysplasia (HP:0007033)2.02969500
80Aortic valve stenosis (HP:0001650)2.01742119
81Vascular tortuosity (HP:0004948)2.00763115
82Cupped ribs (HP:0000887)2.00622513
83Nonimmune hydrops fetalis (HP:0001790)1.99820615
84Pancreatic fibrosis (HP:0100732)1.99625257
85Rhinitis (HP:0012384)1.99401263
86Abnormality of the wing of the ilium (HP:0011867)1.98916040
87Abnormal respiratory motile cilium physiology (HP:0012261)1.98779224
88Blue sclerae (HP:0000592)1.98209289
89Abnormality of the peritoneum (HP:0002585)1.97174746
90Abnormality of the acetabulum (HP:0003170)1.96994165
91Pancreatic cysts (HP:0001737)1.95689220
92Abnormality of alanine metabolism (HP:0010916)1.95641724
93Hyperalaninemia (HP:0003348)1.95641724
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95641724
95Radial bowing (HP:0002986)1.94995557
96Periodontitis (HP:0000704)1.94575280
97Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.94200039
98Centrally nucleated skeletal muscle fibers (HP:0003687)1.94097159
99Abnormality of glutamine family amino acid metabolism (HP:0010902)1.94071877
100Systemic lupus erythematosus (HP:0002725)1.93936571
101Nephronophthisis (HP:0000090)1.92807787
102Limited hip movement (HP:0008800)1.92485520
103Prostate neoplasm (HP:0100787)1.92405822
104Distal lower limb muscle weakness (HP:0009053)1.91733536
105True hermaphroditism (HP:0010459)1.91127336
106Coarse hair (HP:0002208)1.91121867
107Fragile skin (HP:0001030)1.91024294
108Bruising susceptibility (HP:0000978)1.90928739
109Absent/shortened dynein arms (HP:0200106)1.90381080
110Dynein arm defect of respiratory motile cilia (HP:0012255)1.90381080
111Petechiae (HP:0000967)1.89171572
112Abnormality of the nasal septum (HP:0000419)1.88672029
113Increased density of long bones (HP:0006392)1.88524575
114Ulnar bowing (HP:0003031)1.88097693
115Knee flexion contracture (HP:0006380)1.87785520
116Fibular hypoplasia (HP:0003038)1.87654739
117Recurrent fungal infections (HP:0002841)1.83770144
118Aneurysm (HP:0002617)1.83768184
119Wide anterior fontanel (HP:0000260)1.82559948
120Thin bony cortex (HP:0002753)1.81428164
121Abnormal foot bone ossification (HP:0010675)1.80467180
122Chorioretinal atrophy (HP:0000533)1.80432199
123Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80421126
124Fair hair (HP:0002286)1.78525535
125Scapular winging (HP:0003691)1.78416949
126Cellulitis (HP:0100658)1.77589905
127Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.76525398
128Vertebral hypoplasia (HP:0008417)1.76525398
129Beaking of vertebral bodies (HP:0004568)1.76352963
130Arterial tortuosity (HP:0005116)1.74742819
131Mesomelia (HP:0003027)1.74625540
132Occipital encephalocele (HP:0002085)1.73567945
133Neoplasm of the peripheral nervous system (HP:0100007)1.73509753
134Urethral obstruction (HP:0000796)1.73368209
135Broad face (HP:0000283)1.72747411
136Abnormality of the renal medulla (HP:0100957)1.72009584
137Hypoplasia of the odontoid process (HP:0003311)1.71421730
138Aplasia/Hypoplasia of the fibula (HP:0006492)1.71138808
139Abnormality of skull ossification (HP:0002703)1.70785481
140Disproportionate short-trunk short stature (HP:0003521)1.70252932
141Gingival bleeding (HP:0000225)1.69970150
142Spinal rigidity (HP:0003306)1.69791901
143Thick nail (HP:0001805)1.69373830
144Arterial thrombosis (HP:0004420)1.69256105
145Epistaxis (HP:0000421)1.69225344
146Disproportionate tall stature (HP:0001519)1.68819246
147Abnormal delivery (HP:0001787)1.68631641
148Aplasia/Hypoplasia of the tibia (HP:0005772)1.68407564
149Delayed closure of the anterior fontanelle (HP:0001476)1.67755501
150Arthropathy (HP:0003040)1.67395450
151Bowel diverticulosis (HP:0005222)1.66542415
152Intrahepatic cholestasis (HP:0001406)1.65102440
153Genu recurvatum (HP:0002816)1.64985566
154Aplasia/Hypoplasia of the tongue (HP:0010295)1.64823320
155Polydipsia (HP:0001959)1.64693033
156Abnormal drinking behavior (HP:0030082)1.64693033
157Biconcave vertebral bodies (HP:0004586)1.64613904
158Hypoplasia of the fovea (HP:0007750)1.64541405
159Aplasia/Hypoplasia of the fovea (HP:0008060)1.64541405
160Generalized hypopigmentation of hair (HP:0011358)1.64331511
161Entropion (HP:0000621)1.63540563
162Albinism (HP:0001022)1.62954286
163Decreased skull ossification (HP:0004331)1.62805743
164Abnormal delayed hypersensitivity skin test (HP:0002963)1.62385368
165Short nail (HP:0001799)1.62362404
166Bifid tongue (HP:0010297)1.62275217
167Hamartoma of the eye (HP:0010568)1.61670358
168Delayed gross motor development (HP:0002194)1.60828732
169Hypoplastic ischia (HP:0003175)1.60810409
170Metaphyseal cupping (HP:0003021)1.60357660
171Joint laxity (HP:0001388)1.60282768
172Mucopolysacchariduria (HP:0008155)1.59231318
173Urinary glycosaminoglycan excretion (HP:0003541)1.59231318
174Redundant skin (HP:0001582)1.58954800
175Abnormality of the calcaneus (HP:0008364)1.58430239
176Abnormality of the odontoid process (HP:0003310)1.57835338
177Furrowed tongue (HP:0000221)1.55352080
178Abnormality of glycosaminoglycan metabolism (HP:0004371)1.53602960
179Abnormality of mucopolysaccharide metabolism (HP:0011020)1.53602960
180Abnormality of polysaccharide metabolism (HP:0011012)1.53602960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN2.95526475
2PNCK2.93365815
3KIT2.78245332
4TGFBR22.71868251
5PKN22.61896826
6EEF2K2.29843468
7TSSK62.17416722
8PBK2.14460686
9STK38L2.03005943
10STK391.99244950
11CDK121.98503741
12WNK41.94950879
13TRIB31.94753002
14BMPR1B1.93369268
15MYLK1.91565419
16NEK91.91448546
17MAPK151.81453853
18CAMK1D1.75149906
19FLT31.72125347
20PINK11.70640215
21TAOK31.68341196
22EPHB11.65435039
23JAK31.61328688
24PDK21.58065111
25MATK1.57535038
26EIF2AK31.49174810
27CAMKK21.48741017
28STK101.48446636
29MAP2K31.44640728
30FER1.44553153
31CSF1R1.42978321
32TYK21.42446450
33MAP4K11.41042665
34CDK61.40820388
35STK31.40748165
36PTK61.40402582
37AKT31.40348442
38ERN11.39908026
39MAP3K121.39744338
40WEE11.39664598
41MST1R1.39408986
42ADRBK21.38356584
43PAK41.37340048
44TRPM71.33342101
45FGFR21.32239849
46PAK21.27300398
47ERBB41.27103806
48OBSCN1.24818775
49NEK21.24640657
50CAMK1G1.24116842
51RPS6KB21.23193578
52MAP3K101.21082852
53LATS11.20520004
54STK41.19771038
55CLK11.17520403
56SIK11.17116735
57SCYL21.16668400
58IRAK41.16641891
59BRSK21.16118609
60PRKCE1.15613727
61ERBB31.14420778
62TBK11.13993673
63RPS6KA41.13655482
64TGFBR11.13616835
65EPHA31.12059458
66BTK1.10999718
67PIK3CA1.10810266
68PDGFRA1.10422845
69MTOR1.09252787
70RIPK11.07867241
71CDK41.06554378
72PRKG21.02487411
73ZAP701.01298375
74CDC70.99991864
75LRRK20.99868293
76ATR0.99135037
77PTK2B0.98767302
78EPHA20.96665985
79WNK30.96491379
80WNK10.96326366
81IKBKB0.95890814
82MUSK0.95801884
83PLK20.95556701
84GRK10.94807869
85BLK0.94531676
86JAK10.94489963
87MST40.94243387
88CDK90.92897109
89TIE10.91757713
90CHUK0.90021927
91IRAK30.89705017
92MAPKAPK30.87294467
93MKNK10.83278409
94PLK30.82507565
95PASK0.82139280
96MAP3K140.81801392
97MAP3K80.81043562
98CDK30.79574951
99PDGFRB0.79298087
100TTK0.78782648
101MAP3K20.78774810
102TEC0.78666834
103FGFR10.76379195
104CASK0.75306149
105PIM10.74695444
106MET0.74649495
107OXSR10.74620414
108FGFR30.73464048
109ZAK0.72729001
110IKBKE0.72708042
111FRK0.69480360
112CSK0.69416822
113DDR20.68797753
114ADRBK10.67525628
115HCK0.66330598
116ICK0.65524074
117ROCK10.64678140
118YES10.62768136
119LIMK10.62539639
120CDK70.61099563
121DMPK0.60698576
122LCK0.60537147
123MAP3K30.59362163
124PIK3CG0.58991588
125RPS6KA60.58622968
126ACVR1B0.58082128
127GSK3A0.57105766
128AURKB0.55577769
129BRD40.54663221
130NEK10.54369243
131TNIK0.53715545
132PAK30.53289625
133FGFR40.52735740
134PHKG20.52549673
135PHKG10.52549673
136NLK0.51438149
137NUAK10.51368915
138ALK0.50489827
139BMX0.50441310
140RPS6KB10.50432942
141LYN0.50262956
142MAP2K10.48906162
143STK380.47207582
144IGF1R0.46734924
145RPS6KL10.46226112
146RPS6KC10.46226112
147MAPKAPK50.45956846
148NEK60.45936461
149BMPR20.45616045
150ATM0.45462694
151MAPKAPK20.45053605
152PTK20.45024632
153INSRR0.43975629
154AKT20.43209870
155PRKAA20.43032600
156JAK20.43013163
157CAMK2D0.42318600
158MAP2K20.41817572
159ITK0.41686838
160MELK0.41497821
161ERBB20.41024830
162SGK20.39996661
163VRK10.38150277
164IRAK10.37642197
165ROCK20.36108070
166STK240.33210714
167MAP3K70.32968820
168PRKAA10.29939160

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004502.98854439
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.41907839
3Propanoate metabolism_Homo sapiens_hsa006402.32936553
4Maturity onset diabetes of the young_Homo sapiens_hsa049501.97198933
5Nitrogen metabolism_Homo sapiens_hsa009101.96403060
6Fatty acid degradation_Homo sapiens_hsa000711.90599082
7Glycosaminoglycan degradation_Homo sapiens_hsa005311.83160981
8Chronic myeloid leukemia_Homo sapiens_hsa052201.81775794
9ECM-receptor interaction_Homo sapiens_hsa045121.81085941
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.79855880
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78149847
12Steroid biosynthesis_Homo sapiens_hsa001001.76136351
13Complement and coagulation cascades_Homo sapiens_hsa046101.73785349
14Small cell lung cancer_Homo sapiens_hsa052221.73497021
15Sulfur metabolism_Homo sapiens_hsa009201.66278056
16Leishmaniasis_Homo sapiens_hsa051401.65422073
17Tryptophan metabolism_Homo sapiens_hsa003801.64282243
18Other glycan degradation_Homo sapiens_hsa005111.61880059
19PPAR signaling pathway_Homo sapiens_hsa033201.61862929
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.60275055
21Butanoate metabolism_Homo sapiens_hsa006501.57256946
22One carbon pool by folate_Homo sapiens_hsa006701.56875278
23Focal adhesion_Homo sapiens_hsa045101.53628995
24Fatty acid metabolism_Homo sapiens_hsa012121.52931239
25DNA replication_Homo sapiens_hsa030301.51853134
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51698059
27B cell receptor signaling pathway_Homo sapiens_hsa046621.51162302
28Fatty acid biosynthesis_Homo sapiens_hsa000611.50592724
29Platelet activation_Homo sapiens_hsa046111.48144030
30Osteoclast differentiation_Homo sapiens_hsa043801.46637643
31Toxoplasmosis_Homo sapiens_hsa051451.46326393
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.44625782
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.43776891
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43106942
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.43034589
36Staphylococcus aureus infection_Homo sapiens_hsa051501.42961849
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41233156
38beta-Alanine metabolism_Homo sapiens_hsa004101.40975197
39Non-homologous end-joining_Homo sapiens_hsa034501.38982957
40MicroRNAs in cancer_Homo sapiens_hsa052061.37436521
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.36604612
42Histidine metabolism_Homo sapiens_hsa003401.34832163
43Measles_Homo sapiens_hsa051621.32517589
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32490654
45Malaria_Homo sapiens_hsa051441.31094280
46Antigen processing and presentation_Homo sapiens_hsa046121.30598706
47Pyruvate metabolism_Homo sapiens_hsa006201.28868721
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27791420
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.27671257
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27152810
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26458916
52Hematopoietic cell lineage_Homo sapiens_hsa046401.25524001
53Apoptosis_Homo sapiens_hsa042101.23179340
54Acute myeloid leukemia_Homo sapiens_hsa052211.21993531
55Viral myocarditis_Homo sapiens_hsa054161.20961000
56Vitamin B6 metabolism_Homo sapiens_hsa007501.20485086
57Hepatitis B_Homo sapiens_hsa051611.20100777
58Legionellosis_Homo sapiens_hsa051341.19933035
59Pancreatic cancer_Homo sapiens_hsa052121.19159991
60Viral carcinogenesis_Homo sapiens_hsa052031.18125013
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17515665
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17493229
63Shigellosis_Homo sapiens_hsa051311.16481362
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16381041
65Herpes simplex infection_Homo sapiens_hsa051681.16118729
66Adherens junction_Homo sapiens_hsa045201.16117072
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15890937
68Proteoglycans in cancer_Homo sapiens_hsa052051.15779357
69Arginine biosynthesis_Homo sapiens_hsa002201.13238225
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12610291
71Lysosome_Homo sapiens_hsa041421.12214008
72Mineral absorption_Homo sapiens_hsa049781.12128150
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11562865
74Fat digestion and absorption_Homo sapiens_hsa049751.10840940
75Pertussis_Homo sapiens_hsa051331.10514600
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09561722
77Renin-angiotensin system_Homo sapiens_hsa046141.09341984
78Peroxisome_Homo sapiens_hsa041461.08065343
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06591815
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06126885
81Retinol metabolism_Homo sapiens_hsa008301.05256893
82Cell cycle_Homo sapiens_hsa041101.05093803
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04531274
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04456474
85Influenza A_Homo sapiens_hsa051641.03395788
86Amoebiasis_Homo sapiens_hsa051461.03083377
87Sphingolipid metabolism_Homo sapiens_hsa006001.02836853
88Mismatch repair_Homo sapiens_hsa034301.01034976
89Ovarian steroidogenesis_Homo sapiens_hsa049131.01007941
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.99945181
91TNF signaling pathway_Homo sapiens_hsa046680.99894157
92Lysine degradation_Homo sapiens_hsa003100.98541362
93Regulation of autophagy_Homo sapiens_hsa041400.97183911
94Chemical carcinogenesis_Homo sapiens_hsa052040.96536144
95Hippo signaling pathway_Homo sapiens_hsa043900.96392702
96Notch signaling pathway_Homo sapiens_hsa043300.95108773
97Prostate cancer_Homo sapiens_hsa052150.94657769
98p53 signaling pathway_Homo sapiens_hsa041150.94391792
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94239393
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93072837
101Linoleic acid metabolism_Homo sapiens_hsa005910.93004848
102N-Glycan biosynthesis_Homo sapiens_hsa005100.92442529
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91601879
104Thyroid cancer_Homo sapiens_hsa052160.91365735
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90528749
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.89480179
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88691035
108HTLV-I infection_Homo sapiens_hsa051660.86252323
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83150733
110Protein export_Homo sapiens_hsa030600.83003443
111Ether lipid metabolism_Homo sapiens_hsa005650.82666722
112Non-small cell lung cancer_Homo sapiens_hsa052230.82629704
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82470604
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80926346
115Protein digestion and absorption_Homo sapiens_hsa049740.80674520
116Homologous recombination_Homo sapiens_hsa034400.80427643
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79581288
118Dorso-ventral axis formation_Homo sapiens_hsa043200.79264160
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79240340
120Tuberculosis_Homo sapiens_hsa051520.78620493
121Circadian rhythm_Homo sapiens_hsa047100.78581502
122Salmonella infection_Homo sapiens_hsa051320.78042581
123Hedgehog signaling pathway_Homo sapiens_hsa043400.76373943
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75674073
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75519966
126Bladder cancer_Homo sapiens_hsa052190.75259799
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75229214
128Glycerolipid metabolism_Homo sapiens_hsa005610.74955452
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74478278
130Base excision repair_Homo sapiens_hsa034100.74453676
131Thyroid hormone synthesis_Homo sapiens_hsa049180.74335312
132Insulin resistance_Homo sapiens_hsa049310.74212518
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.70054057
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69784901
135Hepatitis C_Homo sapiens_hsa051600.69713936
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69538495
137Caffeine metabolism_Homo sapiens_hsa002320.69484364
138Starch and sucrose metabolism_Homo sapiens_hsa005000.68782103
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68292671
140Pathways in cancer_Homo sapiens_hsa052000.67694414
141Systemic lupus erythematosus_Homo sapiens_hsa053220.67123183
142Bile secretion_Homo sapiens_hsa049760.65364572
143TGF-beta signaling pathway_Homo sapiens_hsa043500.65103145
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64268636
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.63943536
146ABC transporters_Homo sapiens_hsa020100.61306383
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60965054
148Cysteine and methionine metabolism_Homo sapiens_hsa002700.60749042
149Glutathione metabolism_Homo sapiens_hsa004800.60695099
150Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59761372
151Chemokine signaling pathway_Homo sapiens_hsa040620.59684804
152Fanconi anemia pathway_Homo sapiens_hsa034600.59394033
153Tight junction_Homo sapiens_hsa045300.59379349
154Basal cell carcinoma_Homo sapiens_hsa052170.58818831
155Prolactin signaling pathway_Homo sapiens_hsa049170.58551298
156Vitamin digestion and absorption_Homo sapiens_hsa049770.57833032
157Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57648353
158Primary immunodeficiency_Homo sapiens_hsa053400.57333112
159Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56641101
160Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55490246
161HIF-1 signaling pathway_Homo sapiens_hsa040660.55021145
162Galactose metabolism_Homo sapiens_hsa000520.53766650
163Epstein-Barr virus infection_Homo sapiens_hsa051690.53230915
164Dilated cardiomyopathy_Homo sapiens_hsa054140.52896112
165RNA transport_Homo sapiens_hsa030130.52778695
166FoxO signaling pathway_Homo sapiens_hsa040680.52621604
167Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51612032
168Arginine and proline metabolism_Homo sapiens_hsa003300.46186670
169Fatty acid elongation_Homo sapiens_hsa000620.45979331
170Metabolic pathways_Homo sapiens_hsa011000.45476393
171Vascular smooth muscle contraction_Homo sapiens_hsa042700.44581333
172Glucagon signaling pathway_Homo sapiens_hsa049220.42838553
173cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42729826
174Melanoma_Homo sapiens_hsa052180.42478893

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