HDGF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.05886806
2protein localization to kinetochore (GO:0034501)4.93722260
3folic acid-containing compound biosynthetic process (GO:0009396)4.60601412
4nuclear pore organization (GO:0006999)4.59908584
5formation of translation preinitiation complex (GO:0001731)4.56053529
6Golgi transport vesicle coating (GO:0048200)4.54096950
7COPI coating of Golgi vesicle (GO:0048205)4.54096950
8nuclear pore complex assembly (GO:0051292)4.33167229
9protein localization to chromosome, centromeric region (GO:0071459)4.28144108
10mitotic nuclear envelope disassembly (GO:0007077)4.27555177
11DNA replication initiation (GO:0006270)4.15158138
12heterochromatin organization (GO:0070828)4.09703403
13maturation of SSU-rRNA (GO:0030490)4.05248300
14nucleobase biosynthetic process (GO:0046112)4.03392768
15IMP biosynthetic process (GO:0006188)4.02589228
16nuclear envelope disassembly (GO:0051081)3.99299758
17membrane disassembly (GO:0030397)3.99299758
18mitotic metaphase plate congression (GO:0007080)3.97450969
19proline biosynthetic process (GO:0006561)3.97129043
20mitotic sister chromatid segregation (GO:0000070)3.95463649
21DNA strand elongation involved in DNA replication (GO:0006271)3.90436968
22DNA replication-dependent nucleosome assembly (GO:0006335)3.82904736
23DNA replication-dependent nucleosome organization (GO:0034723)3.82904736
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.79617319
25viral transcription (GO:0019083)3.74747480
26ribosome assembly (GO:0042255)3.73932435
27translational termination (GO:0006415)3.72895620
28sister chromatid segregation (GO:0000819)3.69903620
29DNA strand elongation (GO:0022616)3.67901887
30DNA replication checkpoint (GO:0000076)3.65178588
31translational initiation (GO:0006413)3.63021443
32regulation of translational termination (GO:0006449)3.62569685
33regulation of mammary gland epithelial cell proliferation (GO:0033599)3.61572039
34IMP metabolic process (GO:0046040)3.58651678
35purine nucleobase biosynthetic process (GO:0009113)3.56095487
36regulation of translational fidelity (GO:0006450)3.55941441
37ribosomal small subunit assembly (GO:0000028)3.53878394
38ribosome biogenesis (GO:0042254)3.53362965
39regulation of spindle organization (GO:0090224)3.50185388
40positive regulation of chromosome segregation (GO:0051984)3.49081339
41ribosomal large subunit biogenesis (GO:0042273)3.47654673
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.46593732
43translational elongation (GO:0006414)3.45211472
44regulation of posttranscriptional gene silencing (GO:0060147)3.45209948
45regulation of gene silencing by miRNA (GO:0060964)3.45209948
46regulation of gene silencing by RNA (GO:0060966)3.45209948
47DNA duplex unwinding (GO:0032508)3.44723628
48spliceosomal tri-snRNP complex assembly (GO:0000244)3.44631352
49DNA geometric change (GO:0032392)3.42196303
50DNA topological change (GO:0006265)3.40646954
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.40250491
52pre-miRNA processing (GO:0031054)3.40029356
53chromosome condensation (GO:0030261)3.40021179
54cellular protein complex localization (GO:0034629)3.39745653
55pentose-phosphate shunt (GO:0006098)3.39208357
56ribonucleoprotein complex biogenesis (GO:0022613)3.39118454
57maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.37074802
58mitotic chromosome condensation (GO:0007076)3.35361702
59regulation of nucleobase-containing compound transport (GO:0032239)3.34647357
60protein retention in ER lumen (GO:0006621)3.33642350
61planar cell polarity pathway involved in neural tube closure (GO:0090179)3.33607691
62folic acid metabolic process (GO:0046655)3.33196484
63pore complex assembly (GO:0046931)3.31603919
64chromatin assembly (GO:0031497)3.31274883
65metaphase plate congression (GO:0051310)3.29112190
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.28082780
67ribosomal small subunit biogenesis (GO:0042274)3.27173805
68activation of Rac GTPase activity (GO:0032863)3.25842306
69nuclear envelope organization (GO:0006998)3.25263788
70regulation of histone H3-K9 methylation (GO:0051570)3.24452382
71nucleobase-containing small molecule interconversion (GO:0015949)3.22692777
72telomere maintenance via semi-conservative replication (GO:0032201)3.20887190
73protein export from nucleus (GO:0006611)3.15582402
74cell-substrate adherens junction assembly (GO:0007045)3.09618523
75focal adhesion assembly (GO:0048041)3.09618523
76protein localization to chromosome (GO:0034502)3.09482560
77regulation of glucose import in response to insulin stimulus (GO:2001273)3.07059777
78regulation of mitotic spindle organization (GO:0060236)3.06908355
79regulation of early endosome to late endosome transport (GO:2000641)3.06730737
80retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.05255048
81nucleosome disassembly (GO:0006337)3.04712529
82protein-DNA complex disassembly (GO:0032986)3.04712529
83maternal placenta development (GO:0001893)3.04420285
84negative regulation of histone methylation (GO:0031061)3.01662354
85chromatin assembly or disassembly (GO:0006333)3.01297641
86regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.00619613
87desmosome organization (GO:0002934)3.00530699
88adherens junction assembly (GO:0034333)3.00156165
89negative regulation of RNA splicing (GO:0033119)3.00152685
90regulation of chromatin binding (GO:0035561)2.97465383
91rRNA processing (GO:0006364)2.97433548
92NADPH regeneration (GO:0006740)2.96717666
93mRNA stabilization (GO:0048255)2.96592820
94RNA stabilization (GO:0043489)2.96592820
95cellular protein complex disassembly (GO:0043624)2.94356846
96establishment of integrated proviral latency (GO:0075713)2.93952930
973-UTR-mediated mRNA stabilization (GO:0070935)2.93936399
98peptidyl-arginine omega-N-methylation (GO:0035247)2.92339353
99regulation of chromosome segregation (GO:0051983)2.91543360
100regulation of histone H3-K27 methylation (GO:0061085)2.91433714
101rRNA metabolic process (GO:0016072)2.89964907
102glucose catabolic process (GO:0006007)2.88729712
103viral life cycle (GO:0019058)2.88315057
104negative regulation of mRNA processing (GO:0050686)2.87053900
105SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85611844
106regulation of RNA export from nucleus (GO:0046831)2.85569456
107establishment of chromosome localization (GO:0051303)2.85380388
108chaperone-mediated protein complex assembly (GO:0051131)2.83913824
109mitotic G1 DNA damage checkpoint (GO:0031571)2.83712505
110protein complex disassembly (GO:0043241)2.82952713
111chromatin remodeling at centromere (GO:0031055)2.82593416
112DNA replication-independent nucleosome organization (GO:0034724)2.82266801
113DNA replication-independent nucleosome assembly (GO:0006336)2.82266801
114mitotic recombination (GO:0006312)2.82212165
115telomere maintenance via recombination (GO:0000722)2.81010501
116DNA conformation change (GO:0071103)2.80725591
117DNA packaging (GO:0006323)2.80627526
118attachment of spindle microtubules to kinetochore (GO:0008608)2.80369171
119regulation of sister chromatid cohesion (GO:0007063)2.79368972
120RNA splicing, via transesterification reactions (GO:0000375)2.78380491
121histone H2A monoubiquitination (GO:0035518)2.78336736
122apoptotic process involved in morphogenesis (GO:0060561)2.78322390
123mitotic sister chromatid cohesion (GO:0007064)2.78321147
124protein targeting to ER (GO:0045047)2.78106986
125mRNA splicing, via spliceosome (GO:0000398)2.77566497
126RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.77566497
127negative regulation of mRNA metabolic process (GO:1903312)2.77321656
128spliceosomal snRNP assembly (GO:0000387)2.77145462
129cell-substrate junction assembly (GO:0007044)2.76406419
130glucose 6-phosphate metabolic process (GO:0051156)2.75207103
131cotranslational protein targeting to membrane (GO:0006613)2.75049404
132CENP-A containing nucleosome assembly (GO:0034080)2.73645371
133epithelial cell-cell adhesion (GO:0090136)2.72700817
134protein complex localization (GO:0031503)2.71739075
135tetrahydrofolate metabolic process (GO:0046653)2.71153496
136telomere maintenance via telomere lengthening (GO:0010833)2.70772422
137establishment of apical/basal cell polarity (GO:0035089)2.69709861
138positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.69664624
139protein localization to endosome (GO:0036010)2.69602475
140positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.69218370
141proline metabolic process (GO:0006560)2.66694927
142positive regulation of DNA-dependent DNA replication (GO:2000105)2.65695731
143embryonic process involved in female pregnancy (GO:0060136)2.64291954
144cellular response to epidermal growth factor stimulus (GO:0071364)2.61384958
145cytoskeletal anchoring at plasma membrane (GO:0007016)2.60979639
146glucocorticoid receptor signaling pathway (GO:0042921)2.59659107
147urea cycle (GO:0000050)2.58788305
148protoporphyrinogen IX metabolic process (GO:0046501)2.58167383
149protein localization to microtubule (GO:0035372)2.56857154
150hemidesmosome assembly (GO:0031581)2.55499375
151negative regulation of cell size (GO:0045792)2.52221460
152positive regulation of Cdc42 GTPase activity (GO:0043089)2.52085366
153peptidyl-lysine dimethylation (GO:0018027)2.51761083
154positive regulation of keratinocyte differentiation (GO:0045618)2.47869923
155regulation of mRNA stability (GO:0043488)2.46964763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.84750983
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.46325218
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.94823078
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.79117820
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27374215
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96185423
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93652991
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53229042
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.43245731
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40820639
11AR_21909140_ChIP-Seq_LNCAP_Human2.27785622
12MYC_22102868_ChIP-Seq_BL_Human2.27669908
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18910886
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.16380512
15* XRN2_22483619_ChIP-Seq_HELA_Human2.15780779
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06191414
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04991442
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.02367748
19* RACK7_27058665_Chip-Seq_MCF-7_Human1.93278032
20E2F1_21310950_ChIP-Seq_MCF-7_Human1.84415909
21LXR_22292898_ChIP-Seq_THP-1_Human1.76739590
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76370695
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74896526
24CLOCK_20551151_ChIP-Seq_293T_Human1.74684029
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.73814129
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72966927
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72744643
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68636776
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66103357
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66084950
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.65809687
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64862485
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.64724084
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64431281
35ZNF263_19887448_ChIP-Seq_K562_Human1.63684052
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62960520
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62322160
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58893408
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58246417
40VDR_23849224_ChIP-Seq_CD4+_Human1.57141101
41DCP1A_22483619_ChIP-Seq_HELA_Human1.56928451
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51934135
43GABP_19822575_ChIP-Seq_HepG2_Human1.51756205
44* KDM5A_27292631_Chip-Seq_BREAST_Human1.51441885
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50895109
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49848585
47CIITA_25753668_ChIP-Seq_RAJI_Human1.49292787
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49261923
49* TTF2_22483619_ChIP-Seq_HELA_Human1.49116262
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.45079568
51* FOXP3_21729870_ChIP-Seq_TREG_Human1.45006405
52* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44285367
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38421210
54* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36017748
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35954642
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34751193
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33104593
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32549911
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32499466
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32267083
61VDR_21846776_ChIP-Seq_THP-1_Human1.31546300
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30682253
63KDM2B_26808549_Chip-Seq_DND41_Human1.30419376
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30378781
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29789998
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26431734
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24865095
68* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24701130
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22238401
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21830307
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21830307
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21830307
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21726030
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.20763189
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20566610
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19730546
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.18433224
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18400796
79KDM2B_26808549_Chip-Seq_K562_Human1.16828787
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15730487
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15508191
82* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14685570
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13866845
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.12630093
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.12206795
86* TFEB_21752829_ChIP-Seq_HELA_Human1.12164030
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11867482
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11278984
89* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11198144
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.10281375
91* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09984666
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09881340
93ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09803387
94* ATF3_27146783_Chip-Seq_COLON_Human1.09725268
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09410321
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.09221121
97* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08105338
98SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08078723
99* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07521903
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06527487
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06030774
102* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05955907
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04856435
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04381439
105CREB1_26743006_Chip-Seq_LNCaP_Human1.04049450
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03019808
107ELK3_25401928_ChIP-Seq_HUVEC_Human1.01219019
108* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01171750
109GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00679132
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00567232
111CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99835755
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99492177
113NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99453218
114P68_20966046_ChIP-Seq_HELA_Human0.99360894
115* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98991355
116NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97285984
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96356143
118* CHD1_26751641_Chip-Seq_LNCaP_Human0.96142904
119* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96138765
120* RUNX1_27514584_Chip-Seq_MCF-7_Human0.95662941
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95336812
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.95305999
123* UBF1/2_26484160_Chip-Seq_HMECs_Human0.95232551
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95220007
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94935429
126ELK1_19687146_ChIP-ChIP_HELA_Human0.94786619
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94113647
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93690632
129* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93315256
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90465372
131* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90451984
132HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89875934
133SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89394935
134* TCF7_22412390_ChIP-Seq_EML_Mouse0.89062490
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88896913
136* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88423259
137BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88152035
138HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87085979
139* NCOR1_26117541_ChIP-Seq_K562_Human0.85891536
140TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84427517
141E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.83984191

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.44693750
2MP0003111_abnormal_nucleus_morphology4.17705795
3MP0004957_abnormal_blastocyst_morpholog4.07400005
4MP0010094_abnormal_chromosome_stability3.49065993
5MP0003077_abnormal_cell_cycle3.28032376
6MP0010352_gastrointestinal_tract_polyps3.15450028
7MP0003705_abnormal_hypodermis_morpholog3.10298872
8MP0008057_abnormal_DNA_replication2.64637914
9MP0001730_embryonic_growth_arrest2.63005680
10MP0005451_abnormal_body_composition2.42368864
11MP0003123_paternal_imprinting2.26689181
12MP0000350_abnormal_cell_proliferation2.24960975
13MP0008007_abnormal_cellular_replicative2.16092017
14MP0010307_abnormal_tumor_latency2.11153522
15MP0008932_abnormal_embryonic_tissue2.09340376
16MP0005380_embryogenesis_phenotype2.01026572
17MP0001672_abnormal_embryogenesis/_devel2.01026572
18MP0005076_abnormal_cell_differentiation1.97688737
19MP0001697_abnormal_embryo_size1.89010060
20MP0008058_abnormal_DNA_repair1.87502683
21MP0003984_embryonic_growth_retardation1.85392800
22MP0002396_abnormal_hematopoietic_system1.84632652
23MP0002088_abnormal_embryonic_growth/wei1.83441130
24MP0004197_abnormal_fetal_growth/weight/1.80067203
25MP0002084_abnormal_developmental_patter1.77728780
26MP0002086_abnormal_extraembryonic_tissu1.76956555
27MP0002080_prenatal_lethality1.74304067
28MP0002085_abnormal_embryonic_tissue1.71520246
29MP0000566_synostosis1.64738488
30MP0000537_abnormal_urethra_morphology1.64705428
31MP0010030_abnormal_orbit_morphology1.63386467
32MP0000490_abnormal_crypts_of1.60847126
33MP0009379_abnormal_foot_pigmentation1.60320044
34MP0005409_darkened_coat_color1.52611667
35MP0003567_abnormal_fetal_cardiomyocyte1.50525770
36MP0004858_abnormal_nervous_system1.50409594
37MP0003806_abnormal_nucleotide_metabolis1.49785561
38MP0000678_abnormal_parathyroid_gland1.48602747
39MP0005397_hematopoietic_system_phenotyp1.47548317
40MP0001545_abnormal_hematopoietic_system1.47548317
41MP0003566_abnormal_cell_adhesion1.45637141
42MP0001849_ear_inflammation1.44785527
43MP0003786_premature_aging1.38249225
44MP0009053_abnormal_anal_canal1.37597909
45MP0000579_abnormal_nail_morphology1.37518628
46MP0005666_abnormal_adipose_tissue1.29462409
47MP0000313_abnormal_cell_death1.28725799
48MP0001348_abnormal_lacrimal_gland1.28089472
49MP0002877_abnormal_melanocyte_morpholog1.26898104
50MP0004808_abnormal_hematopoietic_stem1.26440882
51MP0009278_abnormal_bone_marrow1.25955896
52MP0009672_abnormal_birth_weight1.25807761
53MP0010234_abnormal_vibrissa_follicle1.24332622
54MP0002019_abnormal_tumor_incidence1.23743492
55MP0005501_abnormal_skin_physiology1.22664625
56MP0008438_abnormal_cutaneous_collagen1.22332986
57MP0003890_abnormal_embryonic-extraembry1.19807955
58MP0001293_anophthalmia1.18686884
59MP0000762_abnormal_tongue_morphology1.17947121
60MP0005257_abnormal_intraocular_pressure1.17480189
61MP0005058_abnormal_lysosome_morphology1.15952817
62MP0005083_abnormal_biliary_tract1.14742432
63MP0002089_abnormal_postnatal_growth/wei1.13748831
64MP0003119_abnormal_digestive_system1.13596014
65MP0005023_abnormal_wound_healing1.12784471
66MP0008260_abnormal_autophagy1.12315417
67MP0002098_abnormal_vibrissa_morphology1.11697630
68MP0000733_abnormal_muscle_development1.08517880
69MP0004272_abnormal_basement_membrane1.07470110
70MP0002249_abnormal_larynx_morphology1.06914065
71MP0004185_abnormal_adipocyte_glucose1.05490807
72MP0000467_abnormal_esophagus_morphology1.04162699
73MP0001346_abnormal_lacrimal_gland1.03630316
74MP0003091_abnormal_cell_migration1.02529101
75MP0002796_impaired_skin_barrier1.02121767
76MP0003718_maternal_effect1.00298683
77MP0009703_decreased_birth_body0.99958897
78MP0000003_abnormal_adipose_tissue0.98128762
79MP0006054_spinal_hemorrhage0.98104467
80MP0002092_abnormal_eye_morphology0.97448021
81MP0005375_adipose_tissue_phenotype0.96758653
82MP0004264_abnormal_extraembryonic_tissu0.95444300
83MP0002009_preneoplasia0.95296002
84MP0003941_abnormal_skin_development0.95168198
85MP0000750_abnormal_muscle_regeneration0.95149926
86MP0001915_intracranial_hemorrhage0.94392673
87MP0000428_abnormal_craniofacial_morphol0.93894765
88MP0002653_abnormal_ependyma_morphology0.93090536
89MP0002111_abnormal_tail_morphology0.92215854
90MP0010630_abnormal_cardiac_muscle0.92085983
91MP0008770_decreased_survivor_rate0.91733071
92MP0003221_abnormal_cardiomyocyte_apopto0.91575889
93MP0003942_abnormal_urinary_system0.90712852
94MP0000358_abnormal_cell_content/0.89859844
95MP0001661_extended_life_span0.89152382
96MP0000627_abnormal_mammary_gland0.89034278
97MP0003656_abnormal_erythrocyte_physiolo0.89012918
98MP0004782_abnormal_surfactant_physiolog0.88556645
99MP0009840_abnormal_foam_cell0.88096970
100MP0002697_abnormal_eye_size0.88058577
101MP0000858_altered_metastatic_potential0.86304739
102MP0009333_abnormal_splenocyte_physiolog0.85894964
103MP0008877_abnormal_DNA_methylation0.82020470
104MP0003121_genomic_imprinting0.78389833
105MP0000747_muscle_weakness0.78061890
106MP0001881_abnormal_mammary_gland0.77615341
107MP0000477_abnormal_intestine_morphology0.77503342
108MP0010771_integument_phenotype0.76864604
109MP0005621_abnormal_cell_physiology0.76358263
110MP0003191_abnormal_cellular_cholesterol0.76110519
111MP0003115_abnormal_respiratory_system0.75906755
112MP0005384_cellular_phenotype0.75127106
113MP0003315_abnormal_perineum_morphology0.73685007
114MP0003453_abnormal_keratinocyte_physiol0.73409857
115MP0001145_abnormal_male_reproductive0.73072011
116MP0002132_abnormal_respiratory_system0.72946071
117MP0001727_abnormal_embryo_implantation0.72482313
118MP0003937_abnormal_limbs/digits/tail_de0.71872678
119MP0002210_abnormal_sex_determination0.71709509
120MP0000703_abnormal_thymus_morphology0.71029868
121MP0000377_abnormal_hair_follicle0.70253980
122MP0001216_abnormal_epidermal_layer0.69944772
123MP0002925_abnormal_cardiovascular_devel0.69729245
124MP0009931_abnormal_skin_appearance0.66512633
125MP0002722_abnormal_immune_system0.66442032
126MP0000432_abnormal_head_morphology0.64709302
127MP0005623_abnormal_meninges_morphology0.64098865
128MP0002269_muscular_atrophy0.62806075
129MP0000598_abnormal_liver_morphology0.62221362
130MP0001286_abnormal_eye_development0.60985347
131MP0000266_abnormal_heart_morphology0.59935002
132MP0003186_abnormal_redox_activity0.58932936
133MP0004233_abnormal_muscle_weight0.56740223
134MP0002060_abnormal_skin_morphology0.56438803
135MP0003300_gastrointestinal_ulcer0.55702737

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)3.90687043
2Hyperacusis (HP:0010780)3.86230014
3Ependymoma (HP:0002888)3.72859658
4Abnormal number of erythroid precursors (HP:0012131)3.66791460
5Selective tooth agenesis (HP:0001592)3.63574094
6Asymmetry of the thorax (HP:0001555)3.37712604
7Reticulocytopenia (HP:0001896)3.31604908
8Birth length less than 3rd percentile (HP:0003561)3.31133139
9Multiple enchondromatosis (HP:0005701)3.16626396
10Breast hypoplasia (HP:0003187)3.02510051
11Trismus (HP:0000211)2.98322145
12Insomnia (HP:0100785)2.90271936
13Ankyloglossia (HP:0010296)2.89997244
14Abnormality of the anterior horn cell (HP:0006802)2.83078025
15Degeneration of anterior horn cells (HP:0002398)2.83078025
16Abnormality of reticulocytes (HP:0004312)2.82327083
17Flat acetabular roof (HP:0003180)2.79245175
18Impulsivity (HP:0100710)2.78861195
19Oral leukoplakia (HP:0002745)2.78110823
20Colon cancer (HP:0003003)2.77950317
21Rhabdomyosarcoma (HP:0002859)2.68399032
22Distal lower limb amyotrophy (HP:0008944)2.64621524
23Reticulocytosis (HP:0001923)2.54608307
24Abnormality of the astrocytes (HP:0100707)2.54086104
25Astrocytoma (HP:0009592)2.54086104
26Patellar aplasia (HP:0006443)2.51668244
27Proximal placement of thumb (HP:0009623)2.51294980
28Macrocytic anemia (HP:0001972)2.51129496
29Deviation of the thumb (HP:0009603)2.49258648
30Carpal bone hypoplasia (HP:0001498)2.46149633
31Abnormality of oral frenula (HP:0000190)2.43673512
32Aplasia/Hypoplasia of the patella (HP:0006498)2.43268764
33Vertebral compression fractures (HP:0002953)2.40540162
34Rough bone trabeculation (HP:0100670)2.37772830
35Medulloblastoma (HP:0002885)2.37447251
36Atresia of the external auditory canal (HP:0000413)2.37439879
37Angiofibromas (HP:0010615)2.37067854
38Adenoma sebaceum (HP:0009720)2.37067854
39Pelvic girdle muscle weakness (HP:0003749)2.34530402
40Pallor (HP:0000980)2.33907723
41Basal cell carcinoma (HP:0002671)2.30682979
42Long palpebral fissure (HP:0000637)2.27382113
43Missing ribs (HP:0000921)2.26580553
44Broad face (HP:0000283)2.25714260
45Increased nuchal translucency (HP:0010880)2.25367395
46Neoplasm of the pancreas (HP:0002894)2.23882728
47Abnormality of the calcaneus (HP:0008364)2.22744932
48Spastic diplegia (HP:0001264)2.21027175
49Squamous cell carcinoma (HP:0002860)2.19737741
50Distal lower limb muscle weakness (HP:0009053)2.19424046
51Neoplasm of striated muscle (HP:0009728)2.19421840
52Termporal pattern (HP:0011008)2.18798918
53Insidious onset (HP:0003587)2.18798918
54Absent radius (HP:0003974)2.18732174
55Short nail (HP:0001799)2.18281457
56Biliary tract neoplasm (HP:0100574)2.17973670
57Prominent nose (HP:0000448)2.16904225
58Back pain (HP:0003418)2.16400428
59Disproportionate tall stature (HP:0001519)2.14452395
60Difficulty climbing stairs (HP:0003551)2.14136761
61Osteolytic defects of the hand bones (HP:0009699)2.11935957
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.11935957
63Sparse lateral eyebrow (HP:0005338)2.10548747
64Absent thumb (HP:0009777)2.10044068
65Overriding aorta (HP:0002623)2.08534185
66Glioma (HP:0009733)2.08398658
67Abnormality of the distal phalanx of the thumb (HP:0009617)2.08181885
68Premature ovarian failure (HP:0008209)2.07049462
69High pitched voice (HP:0001620)2.05539639
70Overlapping toe (HP:0001845)2.05207985
71Renal duplication (HP:0000075)2.04987453
72Chromsome breakage (HP:0040012)2.04951317
73Microretrognathia (HP:0000308)2.03434289
74Ureteral duplication (HP:0000073)2.02960768
75Aplasia/hypoplasia of the humerus (HP:0006507)2.02305847
76Patellar dislocation (HP:0002999)2.00865149
77Abnormality of the labia minora (HP:0012880)1.99571120
78Ankle contracture (HP:0006466)1.99502511
79Absent forearm bone (HP:0003953)1.99334078
80Aplasia involving forearm bones (HP:0009822)1.99334078
81Centrally nucleated skeletal muscle fibers (HP:0003687)1.98867183
82Pseudobulbar signs (HP:0002200)1.98731579
83Rectal prolapse (HP:0002035)1.98684500
84Abnormal gallbladder physiology (HP:0012438)1.96487910
85Cholecystitis (HP:0001082)1.96487910
86Elfin facies (HP:0004428)1.95768574
87Abnormality of the umbilical cord (HP:0010881)1.95319450
88Advanced eruption of teeth (HP:0006288)1.94987816
89Achilles tendon contracture (HP:0001771)1.94815034
90Abnormal number of incisors (HP:0011064)1.94814131
91Spinal cord lesions (HP:0100561)1.93865484
92Syringomyelia (HP:0003396)1.93865484
93Hyperparathyroidism (HP:0000843)1.92001167
94Fragile skin (HP:0001030)1.91574030
95Preauricular skin tag (HP:0000384)1.90838037
96Protrusio acetabuli (HP:0003179)1.89487483
97Increased density of long bones (HP:0006392)1.89093284
9811 pairs of ribs (HP:0000878)1.88264297
99Progressive muscle weakness (HP:0003323)1.87674650
100Distal upper limb amyotrophy (HP:0007149)1.87475452
101Upper limb amyotrophy (HP:0009129)1.87475452
102Malignant gastrointestinal tract tumors (HP:0006749)1.86889028
103Gastrointestinal carcinoma (HP:0002672)1.86889028
104Myelodysplasia (HP:0002863)1.86670113
105Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86576040
106Glossoptosis (HP:0000162)1.86196162
107Skin tags (HP:0010609)1.86098386
108Abnormality of chromosome stability (HP:0003220)1.85842591
109Shoulder girdle muscle weakness (HP:0003547)1.85708738
110Meckel diverticulum (HP:0002245)1.85597175
111Small intestinal stenosis (HP:0012848)1.85493343
112Duodenal stenosis (HP:0100867)1.85493343
113Metaphyseal cupping (HP:0003021)1.85337397
114Cafe-au-lait spot (HP:0000957)1.85017529
115Increased connective tissue (HP:0009025)1.84823611
116Abnormality of the heme biosynthetic pathway (HP:0010472)1.83944972
117Genu recurvatum (HP:0002816)1.83203902
118Deep venous thrombosis (HP:0002625)1.82785765
119Deep philtrum (HP:0002002)1.82776317
120Short humerus (HP:0005792)1.82143129
121Progressive external ophthalmoplegia (HP:0000590)1.81988106
122Abnormality of the musculature of the pelvis (HP:0001469)1.81803620
123Abnormality of the hip-girdle musculature (HP:0001445)1.81803620
124Dysmetric saccades (HP:0000641)1.81106440
125Natal tooth (HP:0000695)1.81059804
126Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80533312
127Abnormality of the Achilles tendon (HP:0005109)1.79327543
128Abnormality of the thoracic spine (HP:0100711)1.79220368
129Atrophy/Degeneration involving motor neurons (HP:0007373)1.77558066
130Arnold-Chiari malformation (HP:0002308)1.77093427
131Abnormality of the salivary glands (HP:0010286)1.74928839
132Spinal cord compression (HP:0002176)1.74742561
133Septate vagina (HP:0001153)1.74735056
134Secondary amenorrhea (HP:0000869)1.74699830
135Rib fusion (HP:0000902)1.74454899
136Lower limb amyotrophy (HP:0007210)1.74225331
137Abnormality of the preputium (HP:0100587)1.73843679
138Thin bony cortex (HP:0002753)1.73573423
139Premature rupture of membranes (HP:0001788)1.73517644
140Calcaneovalgus deformity (HP:0001848)1.73379779
141Slender long bone (HP:0003100)1.72316722
142Broad palm (HP:0001169)1.71741827
143Short middle phalanx of the 5th finger (HP:0004220)1.71263281
144Abnormality of the ileum (HP:0001549)1.71221944
145Ulnar bowing (HP:0003031)1.70962519
146Deep palmar crease (HP:0006191)1.70764979
147Shallow orbits (HP:0000586)1.68335219
148Aplastic anemia (HP:0001915)1.67416216
149Abnormality of the distal phalanges of the toes (HP:0010182)1.67127898
150Agnosia (HP:0010524)1.66631869
151Abnormality of nail color (HP:0100643)1.66392662
152Tracheoesophageal fistula (HP:0002575)1.66016493
153Abnormality of the gastric mucosa (HP:0004295)1.65985613
154Elbow flexion contracture (HP:0002987)1.65777822
155Heterotopia (HP:0002282)1.65012924
156Uterine leiomyosarcoma (HP:0002891)1.63715228
157Leiomyosarcoma (HP:0100243)1.63715228
158Pointed chin (HP:0000307)1.61268339
159Right ventricular cardiomyopathy (HP:0011663)1.61140854
160Orthostatic hypotension (HP:0001278)1.60729400
161High anterior hairline (HP:0009890)1.60652287
162Abnormal ossification of hand bones (HP:0005921)1.60264356
163Broad distal phalanx of finger (HP:0009836)1.60015326
164Flared metaphyses (HP:0003015)1.59835521
165Mitral regurgitation (HP:0001653)1.58305284
166Hypoparathyroidism (HP:0000829)1.57861740
167Renovascular hypertension (HP:0100817)1.57634398
168Ridged nail (HP:0001807)1.56015940
169Abnormality of carpal bone ossification (HP:0006257)1.54200409
170Renal cell carcinoma (HP:0005584)1.53663144
171Abnormality of the tricuspid valve (HP:0001702)1.53656399
172Cholelithiasis (HP:0001081)1.51744460
173Bowel incontinence (HP:0002607)1.51493256
174Abnormal foot bone ossification (HP:0010675)1.51442874

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.61327307
2SMG13.47706916
3WEE13.43990229
4BUB13.27756857
5EEF2K3.18600144
6NEK23.12823469
7IRAK32.94202008
8CDK122.85935859
9TRIB32.64591045
10MST1R2.59667405
11PKN22.55802856
12NEK12.51856393
13SIK12.41269374
14TTK2.39464881
15PRPF4B2.35280012
16MAP3K102.20997616
17EPHA22.14596317
18EIF2AK12.01591209
19RPS6KB22.01225521
20TSSK61.95470209
21NME21.93161599
22CDK41.70202923
23STK101.69398542
24SCYL21.62423170
25MAP3K81.60178171
26PLK11.59447064
27CDK71.56441074
28RPS6KA41.52470788
29BRSK21.51470985
30AURKB1.48531489
31PAK41.47813258
32ALK1.46497059
33FGFR41.46307550
34SRPK11.45666505
35TESK21.43085946
36DYRK31.42916689
37RIPK11.40502627
38PASK1.35876124
39LRRK21.33188894
40PBK1.32974825
41CDK61.25700585
42STK31.21490973
43CHEK11.20189928
44ATR1.18531078
45MKNK11.17142993
46CHEK21.15155091
47TTN1.12784709
48AURKA1.10416888
49MTOR1.06138546
50KSR21.05363985
51PLK31.04997074
52ACVR1B1.01764867
53LATS21.00956214
54LATS10.99885847
55STK40.98839645
56TAOK20.96258938
57MAP2K30.92546665
58BRSK10.92039125
59MKNK20.90832226
60PLK40.89634429
61NTRK10.89172395
62PIM10.88573125
63FLT30.88187906
64CDK20.88135760
65TGFBR10.87147499
66BRAF0.86006620
67PAK20.83690497
68MAP3K90.82229178
69BMX0.80829611
70ICK0.80829394
71PTK60.80158336
72CDK80.78949201
73ATM0.77140372
74AKT20.77081789
75ARAF0.75496771
76GRK60.74993290
77TLK10.74804715
78PAK10.73015534
79PIM20.72743840
80VRK20.69518325
81TESK10.68949933
82IRAK20.67583636
83MAP2K20.67143675
84MAPKAPK30.66942863
85PNCK0.65951005
86PDK40.65419918
87PDK30.65419918
88MAP3K130.65205585
89ERN10.62470475
90DMPK0.62233213
91MAP3K110.60382676
92BRD40.60006324
93* CSNK2A20.56210277
94CLK10.55947282
95CDK10.55928113
96ILK0.54909155
97PDGFRA0.51827102
98* CSNK1E0.51352442
99PRKCI0.50499985
100PDPK10.50404338
101ERBB40.49357743
102MAP3K30.49088462
103EIF2AK30.47616055
104MAP3K10.47262881
105CAMK1D0.44957861
106MELK0.44955185
107TAOK10.44718893
108CSNK2A10.44708357
109TAF10.44553177
110SIK30.43576101
111STK38L0.43041468
112LMTK20.43003357
113RPS6KA10.40981868
114FGFR10.40711943
115RPS6KA20.40550803
116RPS6KC10.40205616
117RPS6KL10.40205616
118MAPK110.40049440
119MAP3K60.39981516
120MAP3K20.39307914
121MET0.39273280
122RET0.38832321
123TYRO30.36673540
124CDK90.35932843
125MARK20.35885716
126VRK10.34688248
127PRKDC0.33560731
128KSR10.33110687
129CDC42BPA0.32767932
130CDK11A0.32627847
131DYRK1B0.31093411
132KDR0.31043360
133BCKDK0.30695492
134CSNK1D0.30575501
135PTK20.28339733
136MAPKAPK20.27214032
137MAPK140.26512359
138MAP4K10.26413098
139MAPK10.25508878

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.26343225
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56577366
3RNA transport_Homo sapiens_hsa030133.44231559
4Mismatch repair_Homo sapiens_hsa034303.28839768
5Spliceosome_Homo sapiens_hsa030403.16398409
6One carbon pool by folate_Homo sapiens_hsa006703.06320802
7Ribosome_Homo sapiens_hsa030103.04750270
8Cell cycle_Homo sapiens_hsa041102.73331708
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59249773
10Base excision repair_Homo sapiens_hsa034102.46077875
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.43465394
12RNA polymerase_Homo sapiens_hsa030202.35692786
13Nucleotide excision repair_Homo sapiens_hsa034202.28265699
14Proteasome_Homo sapiens_hsa030502.02877624
15Homologous recombination_Homo sapiens_hsa034402.02035847
16mRNA surveillance pathway_Homo sapiens_hsa030152.01241133
17Vitamin B6 metabolism_Homo sapiens_hsa007501.95794288
18Pyrimidine metabolism_Homo sapiens_hsa002401.83973364
19p53 signaling pathway_Homo sapiens_hsa041151.66574603
20Biosynthesis of amino acids_Homo sapiens_hsa012301.51878992
21RNA degradation_Homo sapiens_hsa030181.49444388
22Fanconi anemia pathway_Homo sapiens_hsa034601.43756144
23Pentose phosphate pathway_Homo sapiens_hsa000301.39833893
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.36015675
25Renal cell carcinoma_Homo sapiens_hsa052111.34764882
26Selenocompound metabolism_Homo sapiens_hsa004501.34130876
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.28141444
28VEGF signaling pathway_Homo sapiens_hsa043701.23571413
29Non-homologous end-joining_Homo sapiens_hsa034501.19321389
30Prion diseases_Homo sapiens_hsa050201.17696432
31Glioma_Homo sapiens_hsa052141.17576687
32Sulfur relay system_Homo sapiens_hsa041221.17359064
33Basal transcription factors_Homo sapiens_hsa030221.13016237
34Systemic lupus erythematosus_Homo sapiens_hsa053221.11585224
35Viral carcinogenesis_Homo sapiens_hsa052031.11576964
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10782883
37Thyroid cancer_Homo sapiens_hsa052161.10507073
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10297106
39Carbon metabolism_Homo sapiens_hsa012001.07713835
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06456095
41Insulin signaling pathway_Homo sapiens_hsa049101.05858769
42ErbB signaling pathway_Homo sapiens_hsa040121.05750032
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02946978
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02532516
45Bladder cancer_Homo sapiens_hsa052191.01320490
46Small cell lung cancer_Homo sapiens_hsa052221.00961107
47Arginine biosynthesis_Homo sapiens_hsa002200.97085833
48Epstein-Barr virus infection_Homo sapiens_hsa051690.96837413
49MicroRNAs in cancer_Homo sapiens_hsa052060.96580425
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93567038
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92337773
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91100803
53Antigen processing and presentation_Homo sapiens_hsa046120.89981853
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.88821089
55Chronic myeloid leukemia_Homo sapiens_hsa052200.87553672
56Oocyte meiosis_Homo sapiens_hsa041140.87326744
57Other glycan degradation_Homo sapiens_hsa005110.86503220
58N-Glycan biosynthesis_Homo sapiens_hsa005100.85420047
59HTLV-I infection_Homo sapiens_hsa051660.85224685
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.84810178
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.84112929
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82974986
63Hippo signaling pathway_Homo sapiens_hsa043900.82402218
64Purine metabolism_Homo sapiens_hsa002300.77734211
65mTOR signaling pathway_Homo sapiens_hsa041500.76625615
66Fructose and mannose metabolism_Homo sapiens_hsa000510.75291089
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74624941
68Folate biosynthesis_Homo sapiens_hsa007900.74490156
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73687666
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72630284
71Herpes simplex infection_Homo sapiens_hsa051680.71293781
72Phenylalanine metabolism_Homo sapiens_hsa003600.70688041
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65683322
74Basal cell carcinoma_Homo sapiens_hsa052170.63398615
75Lysine degradation_Homo sapiens_hsa003100.61239767
76Hepatitis C_Homo sapiens_hsa051600.60764297
77Choline metabolism in cancer_Homo sapiens_hsa052310.58154984
78Acute myeloid leukemia_Homo sapiens_hsa052210.57930371
79Glutathione metabolism_Homo sapiens_hsa004800.57765363
80Apoptosis_Homo sapiens_hsa042100.57071264
81Estrogen signaling pathway_Homo sapiens_hsa049150.56822866
82Adherens junction_Homo sapiens_hsa045200.56811474
83B cell receptor signaling pathway_Homo sapiens_hsa046620.56620512
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55771832
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55587711
86Prolactin signaling pathway_Homo sapiens_hsa049170.54753787
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53639726
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53549495
89Non-small cell lung cancer_Homo sapiens_hsa052230.53297216
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52957444
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52683999
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51677278
93Inositol phosphate metabolism_Homo sapiens_hsa005620.51572670
94Proteoglycans in cancer_Homo sapiens_hsa052050.51476029
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.50916523
96Amoebiasis_Homo sapiens_hsa051460.49846201
97Notch signaling pathway_Homo sapiens_hsa043300.49829467
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.49220339
99Colorectal cancer_Homo sapiens_hsa052100.47615567
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47460260
101TGF-beta signaling pathway_Homo sapiens_hsa043500.47346198
102Insulin resistance_Homo sapiens_hsa049310.46881196
103Legionellosis_Homo sapiens_hsa051340.45401133
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44644834
105HIF-1 signaling pathway_Homo sapiens_hsa040660.43598070
106AMPK signaling pathway_Homo sapiens_hsa041520.42868992
107Tight junction_Homo sapiens_hsa045300.41740156
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41288054
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41173693
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40009965
111Endometrial cancer_Homo sapiens_hsa052130.38950740
112Galactose metabolism_Homo sapiens_hsa000520.38832562
113Prostate cancer_Homo sapiens_hsa052150.38595239
114Hedgehog signaling pathway_Homo sapiens_hsa043400.35832862
115Pathways in cancer_Homo sapiens_hsa052000.33708135
116Hepatitis B_Homo sapiens_hsa051610.33110463
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27869086
118Arginine and proline metabolism_Homo sapiens_hsa003300.26357555
119Pyruvate metabolism_Homo sapiens_hsa006200.24369713
120Nitrogen metabolism_Homo sapiens_hsa009100.23730221
121Melanoma_Homo sapiens_hsa052180.23265757
122Shigellosis_Homo sapiens_hsa051310.22451122
123FoxO signaling pathway_Homo sapiens_hsa040680.22168737
124Pancreatic cancer_Homo sapiens_hsa052120.21707475
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21572175
126Focal adhesion_Homo sapiens_hsa045100.20725489
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20549891
128Viral myocarditis_Homo sapiens_hsa054160.20377640
129Alcoholism_Homo sapiens_hsa050340.19526498
130ECM-receptor interaction_Homo sapiens_hsa045120.19237357

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