HDAC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.13124129
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.58554241
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.47837713
4locomotory exploration behavior (GO:0035641)4.43783340
5sodium ion export (GO:0071436)4.17141028
6negative regulation of erythrocyte differentiation (GO:0045647)4.04758957
7layer formation in cerebral cortex (GO:0021819)3.97381123
8cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.81190051
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.75540237
10regulation of synapse structural plasticity (GO:0051823)3.57611748
11cellular potassium ion homeostasis (GO:0030007)3.56210043
12cell communication by electrical coupling (GO:0010644)3.52910672
13cytoskeletal anchoring at plasma membrane (GO:0007016)3.51517626
14synaptic vesicle exocytosis (GO:0016079)3.49163565
15activation of protein kinase A activity (GO:0034199)3.44400806
16glutamate secretion (GO:0014047)3.44215239
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.43697017
18regulation of ARF protein signal transduction (GO:0032012)3.43292297
19vocalization behavior (GO:0071625)3.42465915
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.41004598
21regulation of synaptic vesicle exocytosis (GO:2000300)3.36787911
22positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.29946439
23potassium ion import (GO:0010107)3.24551859
24dendritic spine morphogenesis (GO:0060997)3.22641100
25regulation of glutamate receptor signaling pathway (GO:1900449)3.20750372
26negative regulation of potassium ion transmembrane transport (GO:1901380)3.08702626
27cerebellar granule cell differentiation (GO:0021707)3.02915008
28neurotransmitter secretion (GO:0007269)3.00921299
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00558281
30glycine transport (GO:0015816)3.00515472
31negative regulation of cell size (GO:0045792)3.00195015
32cerebellar Purkinje cell layer development (GO:0021680)3.00126399
33exploration behavior (GO:0035640)2.98879457
34regulation of synaptic vesicle transport (GO:1902803)2.98184797
35plasma membrane repair (GO:0001778)2.97820652
36negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.96205281
37proline transport (GO:0015824)2.95303078
38neuromuscular process controlling balance (GO:0050885)2.91624100
39gamma-aminobutyric acid transport (GO:0015812)2.90158700
40regulation of ARF GTPase activity (GO:0032312)2.89788856
41regulation of neuronal synaptic plasticity (GO:0048168)2.89667673
42cell communication involved in cardiac conduction (GO:0086065)2.89346264
43regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.84585425
44potassium ion homeostasis (GO:0055075)2.83568767
45regulation of synapse maturation (GO:0090128)2.82871143
46mannose metabolic process (GO:0006013)2.79687297
47protein localization to synapse (GO:0035418)2.79364203
48cellular sodium ion homeostasis (GO:0006883)2.79189284
49positive regulation of synapse maturation (GO:0090129)2.79013447
50negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78913885
51cell-cell junction maintenance (GO:0045217)2.78483605
52dendrite morphogenesis (GO:0048813)2.76404291
53protein targeting to plasma membrane (GO:0072661)2.74095292
54regulation of long-term neuronal synaptic plasticity (GO:0048169)2.74038477
55negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73234776
56protein localization to endosome (GO:0036010)2.68130058
57negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.67550323
58negative regulation of cell killing (GO:0031342)2.67550323
59neuromuscular process controlling posture (GO:0050884)2.65919592
60establishment of mitochondrion localization (GO:0051654)2.64694347
61establishment of nucleus localization (GO:0040023)2.62017387
62regulation of T-helper 2 cell differentiation (GO:0045628)2.61507115
63cell migration in hindbrain (GO:0021535)2.59853225
64long-term memory (GO:0007616)2.56794965
65ionotropic glutamate receptor signaling pathway (GO:0035235)2.55836726
66cerebellar Purkinje cell differentiation (GO:0021702)2.54284080
67regulation of clathrin-mediated endocytosis (GO:2000369)2.53656454
68regulation of membrane repolarization (GO:0060306)2.50434036
69mitochondrion transport along microtubule (GO:0047497)2.48904153
70establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.48904153
71response to muramyl dipeptide (GO:0032495)2.48474872
72regulation of dendritic spine morphogenesis (GO:0061001)2.46741070
73barbed-end actin filament capping (GO:0051016)2.46676483
74G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.45996739
75neuronal action potential propagation (GO:0019227)2.44994722
76membrane repolarization (GO:0086009)2.43304398
77regulation of Rap GTPase activity (GO:0032317)2.42635671
78mating behavior (GO:0007617)2.41359535
79neurotransmitter-gated ion channel clustering (GO:0072578)2.40868732
80cardiac myofibril assembly (GO:0055003)2.40704811
81synaptic transmission, glutamatergic (GO:0035249)2.39454375
82signal complex assembly (GO:0007172)2.39303913
83regulation of regulated secretory pathway (GO:1903305)2.37537691
84auditory behavior (GO:0031223)2.37324712
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37270980
86creatine metabolic process (GO:0006600)2.36906145
87membrane depolarization during action potential (GO:0086010)2.36386214
88cellular response to catecholamine stimulus (GO:0071870)2.35242168
89cellular response to monoamine stimulus (GO:0071868)2.35242168
90neurotransmitter transport (GO:0006836)2.35176956
91regulation of calcium ion transmembrane transport (GO:1903169)2.35108193
92regulation of calcium ion transmembrane transporter activity (GO:1901019)2.35108193
93positive regulation of membrane potential (GO:0045838)2.34952242
94prepulse inhibition (GO:0060134)2.34660016
95intracellular estrogen receptor signaling pathway (GO:0030520)2.34016935
96neuromuscular junction development (GO:0007528)2.33799091
97alanine transport (GO:0032328)2.32855118
98positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.32627356
99regulation of leukocyte degranulation (GO:0043300)2.32491598
100neuronal ion channel clustering (GO:0045161)2.31942417
101regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.31526813
102positive regulation of potassium ion transmembrane transport (GO:1901381)2.30507238
103regulation of myeloid leukocyte mediated immunity (GO:0002886)2.30398980
104stress fiber assembly (GO:0043149)2.29981124
105synaptic vesicle endocytosis (GO:0048488)2.29760162
106dopamine receptor signaling pathway (GO:0007212)2.29749606
107regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.29703515
108nerve growth factor signaling pathway (GO:0038180)2.29134381
109vesicle transport along microtubule (GO:0047496)2.28764203
110cardiac muscle contraction (GO:0060048)2.28552147
111activation of JUN kinase activity (GO:0007257)2.28233963
112peptidyl-tyrosine autophosphorylation (GO:0038083)2.27569250
113organelle transport along microtubule (GO:0072384)2.26457953
114respiratory system process (GO:0003016)2.25819817
115regulation of excitatory postsynaptic membrane potential (GO:0060079)2.25817029
116regulation of NFAT protein import into nucleus (GO:0051532)2.25219829
117cell junction maintenance (GO:0034331)2.25054636
118positive regulation of histone deacetylation (GO:0031065)2.24650376
119positive regulation of receptor recycling (GO:0001921)2.23872500
120axonal fasciculation (GO:0007413)2.23465876
121positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.23154888
122membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.22884236
123negative regulation of necrotic cell death (GO:0060547)2.22673962
124activation of MAPKKK activity (GO:0000185)2.22612363
125positive regulation by symbiont of host defense response (GO:0052509)2.22194234
126modulation by symbiont of host defense response (GO:0052031)2.22194234
127modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.22194234
128modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.22194234
129positive regulation by organism of defense response of other organism involved in symbiotic interact2.22194234
130modulation by symbiont of host immune response (GO:0052553)2.22194234
131neuron recognition (GO:0008038)2.21621044
132positive regulation of Rap GTPase activity (GO:0032854)2.21418858
133dendritic spine organization (GO:0097061)2.20796613
134response to auditory stimulus (GO:0010996)2.20153662
135adherens junction assembly (GO:0034333)2.20112749
136regulation of synaptic plasticity (GO:0048167)2.19499598
137positive regulation of sodium ion transport (GO:0010765)2.19498594
138amino acid import (GO:0043090)2.18389110
139suckling behavior (GO:0001967)2.18225025
140regulation of early endosome to late endosome transport (GO:2000641)2.17631319
141L-amino acid import (GO:0043092)2.16766090
142adenosine receptor signaling pathway (GO:0001973)2.16289506
143negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.15241629
144regulation of mast cell degranulation (GO:0043304)2.14942902
145regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.14173269
146negative regulation of toll-like receptor signaling pathway (GO:0034122)2.10957736
1473-UTR-mediated mRNA stabilization (GO:0070935)2.10017598
148actin filament polymerization (GO:0030041)2.09371244
149regulation of glycogen (starch) synthase activity (GO:2000465)2.07742736
150semaphorin-plexin signaling pathway (GO:0071526)2.07599831
151detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.06616076
152detection of temperature stimulus involved in sensory perception (GO:0050961)2.06616076
153positive regulation of protein dephosphorylation (GO:0035307)2.06493186
154cellular response to epinephrine stimulus (GO:0071872)2.06043525
155negative regulation of glial cell proliferation (GO:0060253)2.05575008
156cell-substrate adherens junction assembly (GO:0007045)2.03081124

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.37699426
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.81343789
3DROSHA_22980978_ChIP-Seq_HELA_Human2.52250389
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.44855177
5VDR_21846776_ChIP-Seq_THP-1_Human2.34255847
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.23207659
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22134457
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22134457
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21813928
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18152282
11KDM2B_26808549_Chip-Seq_K562_Human2.18148388
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09985601
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07270199
14* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.06356955
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03120273
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01628691
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00822180
18LXR_22292898_ChIP-Seq_THP-1_Human1.94423566
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.93440093
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.92756437
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91047331
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87277410
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86292665
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86039604
25KDM2B_26808549_Chip-Seq_DND41_Human1.86011162
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83084782
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81047668
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.80760809
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.79303803
30* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.75924847
31MYC_22102868_ChIP-Seq_BL_Human1.75586214
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.75179210
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72689793
34REST_21632747_ChIP-Seq_MESCs_Mouse1.71533249
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.70314516
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68836820
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68162866
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64120089
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.63763882
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.63337882
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57872530
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.57543565
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.54927101
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.49889762
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.49815849
46* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47222476
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46498570
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45144565
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.44310502
50VDR_24763502_ChIP-Seq_THP-1_Human1.43349170
51* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.42583807
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40925137
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39832099
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35184822
55CTCF_27219007_Chip-Seq_Bcells_Human1.34502674
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32885486
57CREB1_26743006_Chip-Seq_LNCaP_Human1.32385722
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.32365268
59* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31638844
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31191837
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.30906299
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28844605
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28448232
64SMC4_20622854_ChIP-Seq_HELA_Human1.27958005
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25571096
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.24878909
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24209429
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24162400
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22589081
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22516687
71SCL_19346495_ChIP-Seq_HPC-7_Human1.21932718
72* TCF7_22412390_ChIP-Seq_EML_Mouse1.21609751
73ZNF263_19887448_ChIP-Seq_K562_Human1.21035540
74MAF_26560356_Chip-Seq_TH1_Human1.19427508
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17708233
76* BCOR_27268052_Chip-Seq_Bcells_Human1.17703265
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17048463
78UTX_26944678_Chip-Seq_JUKART_Human1.16437121
79RACK7_27058665_Chip-Seq_MCF-7_Human1.15211036
80* BCL6_27268052_Chip-Seq_Bcells_Human1.14569635
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14531449
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.14526030
83MAF_26560356_Chip-Seq_TH2_Human1.13652333
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.12770286
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12610513
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12430774
87* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11801521
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09789938
89PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09557283
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09177992
91TET1_21490601_ChIP-Seq_MESCs_Mouse1.08936601
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.08597730
93* SPI1_23127762_ChIP-Seq_K562_Human1.07557106
94* P68_20966046_ChIP-Seq_HELA_Human1.06709523
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06657390
96* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06474655
97* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05981297
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04938783
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04420605
100* TBX20_22080862_ChIP-Seq_HEART_Mouse1.04231714
101* TBX20_22328084_ChIP-Seq_HEART_Mouse1.04231714
102GATA1_19941826_ChIP-Seq_K562_Human1.03590912
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02484618
104SA1_27219007_Chip-Seq_Bcells_Human1.01648558
105* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00942834
106ESR1_20079471_ChIP-ChIP_T-47D_Human1.00656156
107* AR_19668381_ChIP-Seq_PC3_Human0.99410747
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99339456
109UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98631789
110AR_21572438_ChIP-Seq_LNCaP_Human0.98307135
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97551379
112* TP63_22573176_ChIP-Seq_HFKS_Human0.97442392
113BP1_19119308_ChIP-ChIP_Hs578T_Human0.96777102
114KLF4_19829295_ChIP-Seq_ESCs_Human0.96366370
115* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95871298
116OCT4_19829295_ChIP-Seq_ESCs_Human0.95517423
117RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94770967
118PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94151373
119ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93743335
120TP53_20018659_ChIP-ChIP_R1E_Mouse0.92619481
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91928445
122EP300_21415370_ChIP-Seq_HL-1_Mouse0.90179964
123TP53_23651856_ChIP-Seq_MEFs_Mouse0.89634865
124RUNX1_27514584_Chip-Seq_MCF-7_Human0.87419655
125SMAD3_21741376_ChIP-Seq_HESCs_Human0.86903829
126FOXA2_19822575_ChIP-Seq_HepG2_Human0.86386101
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.85993545
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85876975
129TRIM28_21343339_ChIP-Seq_HEK293_Human0.85660933
130* AHR_22903824_ChIP-Seq_MCF-7_Human0.85607637
131CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85413796
132ISL1_27105846_Chip-Seq_CPCs_Mouse0.84984836

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.29833082
2MP0003635_abnormal_synaptic_transmissio3.02944188
3MP0004270_analgesia2.79393808
4MP0000751_myopathy2.59831514
5MP0002909_abnormal_adrenal_gland2.59000576
6MP0008961_abnormal_basal_metabolism2.46275166
7MP0002837_dystrophic_cardiac_calcinosis2.41999944
8MP0009278_abnormal_bone_marrow2.41040898
9MP0008260_abnormal_autophagy2.31579008
10MP0004858_abnormal_nervous_system2.26024574
11MP0009780_abnormal_chondrocyte_physiolo2.20541314
12MP0002063_abnormal_learning/memory/cond2.18243339
13MP0002064_seizures2.17836004
14MP0005409_darkened_coat_color2.11636411
15MP0003705_abnormal_hypodermis_morpholog2.10484178
16MP0003283_abnormal_digestive_organ2.08327425
17MP0003436_decreased_susceptibility_to2.06054386
18MP0005058_abnormal_lysosome_morphology2.04816446
19MP0009046_muscle_twitch2.00989229
20MP0005423_abnormal_somatic_nervous1.99230540
21MP0009745_abnormal_behavioral_response1.97211553
22MP0004130_abnormal_muscle_cell1.92263242
23MP0003329_amyloid_beta_deposits1.86801182
24MP0003880_abnormal_central_pattern1.86251382
25MP0001486_abnormal_startle_reflex1.77175453
26MP0004145_abnormal_muscle_electrophysio1.76495054
27MP0001958_emphysema1.74707366
28MP0004885_abnormal_endolymph1.74235391
29MP0002822_catalepsy1.73580966
30MP0002572_abnormal_emotion/affect_behav1.72113144
31MP0004084_abnormal_cardiac_muscle1.70230931
32MP0008569_lethality_at_weaning1.65641477
33MP0002272_abnormal_nervous_system1.60797572
34MP0004036_abnormal_muscle_relaxation1.60604973
35MP0000013_abnormal_adipose_tissue1.60095688
36MP0003279_aneurysm1.49670351
37MP0005451_abnormal_body_composition1.47329948
38MP0004087_abnormal_muscle_fiber1.47142445
39MP0003137_abnormal_impulse_conducting1.44025683
40MP0000747_muscle_weakness1.43929490
41MP0004185_abnormal_adipocyte_glucose1.43229437
42MP0002734_abnormal_mechanical_nocicepti1.43133867
43MP0004811_abnormal_neuron_physiology1.41539253
44MP0003724_increased_susceptibility_to1.40631336
45MP0004510_myositis1.39900864
46MP0009840_abnormal_foam_cell1.39826611
47MP0004233_abnormal_muscle_weight1.39602205
48MP0000003_abnormal_adipose_tissue1.37942947
49MP0000955_abnormal_spinal_cord1.35976540
50MP0005623_abnormal_meninges_morphology1.34961094
51MP0003191_abnormal_cellular_cholesterol1.33580914
52MP0004085_abnormal_heartbeat1.33185420
53MP0000749_muscle_degeneration1.32782979
54MP0004215_abnormal_myocardial_fiber1.29847743
55MP0003633_abnormal_nervous_system1.28951903
56MP0002234_abnormal_pharynx_morphology1.26287365
57MP0005330_cardiomyopathy1.26175578
58MP0002249_abnormal_larynx_morphology1.25883817
59MP0005375_adipose_tissue_phenotype1.25221408
60MP0003690_abnormal_glial_cell1.20734594
61MP0003075_altered_response_to1.18850365
62MP0002733_abnormal_thermal_nociception1.17908869
63MP0002882_abnormal_neuron_morphology1.17313176
64MP0005620_abnormal_muscle_contractility1.16953745
65MP0010234_abnormal_vibrissa_follicle1.16420176
66MP0005076_abnormal_cell_differentiation1.16180708
67MP0001440_abnormal_grooming_behavior1.15467446
68MP0002269_muscular_atrophy1.14523088
69MP0002184_abnormal_innervation1.12108010
70MP0001501_abnormal_sleep_pattern1.10493319
71MP0000778_abnormal_nervous_system1.10002729
72MP0001970_abnormal_pain_threshold1.09634468
73MP0005666_abnormal_adipose_tissue1.09607182
74MP0002067_abnormal_sensory_capabilities1.09312360
75MP0002066_abnormal_motor_capabilities/c1.08858135
76MP0003045_fibrosis1.08832916
77MP0005167_abnormal_blood-brain_barrier1.08832401
78MP0002090_abnormal_vision1.08611544
79MP0005464_abnormal_platelet_physiology1.08265485
80* MP0000759_abnormal_skeletal_muscle1.07574489
81MP0003646_muscle_fatigue1.07303329
82MP0003828_pulmonary_edema1.07229797
83MP0003634_abnormal_glial_cell1.06191678
84MP0001968_abnormal_touch/_nociception1.04411974
85MP0001984_abnormal_olfaction1.04144387
86MP0002557_abnormal_social/conspecific_i1.03167734
87MP0002972_abnormal_cardiac_muscle1.02660236
88MP0003303_peritoneal_inflammation1.02349503
89MP0005551_abnormal_eye_electrophysiolog1.00271213
90MP0003879_abnormal_hair_cell0.99318203
91MP0001533_abnormal_skeleton_physiology0.99091710
92MP0002998_abnormal_bone_remodeling0.98536995
93MP0004043_abnormal_pH_regulation0.97805163
94MP0002106_abnormal_muscle_physiology0.96810349
95MP0003172_abnormal_lysosome_physiology0.95786082
96MP0003122_maternal_imprinting0.95563805
97MP0004924_abnormal_behavior0.94669848
98MP0005386_behavior/neurological_phenoty0.94669848
99MP0000920_abnormal_myelination0.94608945
100MP0001348_abnormal_lacrimal_gland0.93837982
101MP0002229_neurodegeneration0.93344262
102MP0003566_abnormal_cell_adhesion0.93103845
103MP0010630_abnormal_cardiac_muscle0.92565762
104MP0001502_abnormal_circadian_rhythm0.92232908
105MP0003183_abnormal_peptide_metabolism0.91467460
106MP0008874_decreased_physiological_sensi0.91416121
107MP0008438_abnormal_cutaneous_collagen0.91270452
108MP0000681_abnormal_thyroid_gland0.91229649
109MP0002419_abnormal_innate_immunity0.89384877
110MP0002152_abnormal_brain_morphology0.89036259
111MP0003631_nervous_system_phenotype0.87338040
112MP0000465_gastrointestinal_hemorrhage0.86800022
113MP0003091_abnormal_cell_migration0.86070051
114MP0000604_amyloidosis0.85939862
115MP0000750_abnormal_muscle_regeneration0.85874769
116MP0002653_abnormal_ependyma_morphology0.84805229
117MP0005670_abnormal_white_adipose0.84616754
118MP0001299_abnormal_eye_distance/0.84576928
119MP0005369_muscle_phenotype0.83341314
120MP0003787_abnormal_imprinting0.83101090
121MP0008775_abnormal_heart_ventricle0.81795167
122MP0001849_ear_inflammation0.80328473
123MP0002089_abnormal_postnatal_growth/wei0.79362650
124MP0003300_gastrointestinal_ulcer0.78759873
125MP0003123_paternal_imprinting0.78754304
126MP0000678_abnormal_parathyroid_gland0.78658777
127MP0004484_altered_response_of0.77396864
128MP0004947_skin_inflammation0.76769264
129MP0001545_abnormal_hematopoietic_system0.75290740
130MP0005397_hematopoietic_system_phenotyp0.75290740
131MP0006138_congestive_heart_failure0.75203575
132MP0002069_abnormal_eating/drinking_beha0.75027691
133MP0001851_eye_inflammation0.74349326
134MP0005025_abnormal_response_to0.72882469
135MP0006276_abnormal_autonomic_nervous0.72679752
136MP0000767_abnormal_smooth_muscle0.72615196
137MP0002933_joint_inflammation0.72594999
138MP0003948_abnormal_gas_homeostasis0.68631535
139MP0005535_abnormal_body_temperature0.67494384

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)3.90559325
2Myokymia (HP:0002411)3.76740916
3Supranuclear gaze palsy (HP:0000605)3.61528241
4Visual hallucinations (HP:0002367)3.46374730
5Sudden death (HP:0001699)3.14727582
6Abnormality of the lower motor neuron (HP:0002366)3.12297948
7Hyperacusis (HP:0010780)3.11287665
8Focal seizures (HP:0007359)3.07550808
9Ventricular fibrillation (HP:0001663)3.00463408
10Neoplasm of the heart (HP:0100544)2.98215316
11Ankle clonus (HP:0011448)2.96778256
12Difficulty running (HP:0009046)2.92756064
13Insomnia (HP:0100785)2.89511503
14Cerebral aneurysm (HP:0004944)2.87569550
15Distal upper limb amyotrophy (HP:0007149)2.85530751
16Upper limb amyotrophy (HP:0009129)2.85530751
17Exercise-induced myalgia (HP:0003738)2.83104100
18Centrally nucleated skeletal muscle fibers (HP:0003687)2.76526468
19Depression (HP:0000716)2.76303145
20Diplopia (HP:0000651)2.74686572
21Abnormality of binocular vision (HP:0011514)2.74686572
22Focal motor seizures (HP:0011153)2.73156589
23Type 1 muscle fiber predominance (HP:0003803)2.65683067
24Peripheral hypomyelination (HP:0007182)2.65036743
25Bundle branch block (HP:0011710)2.64612555
26Action tremor (HP:0002345)2.63935212
27Eczematoid dermatitis (HP:0000976)2.61413725
28Annular pancreas (HP:0001734)2.60606971
29Hyporeflexia of lower limbs (HP:0002600)2.57513464
30Hamartoma of the eye (HP:0010568)2.51575055
31Cerebral inclusion bodies (HP:0100314)2.51042791
32Dysmetric saccades (HP:0000641)2.49028746
33Achilles tendon contracture (HP:0001771)2.48778209
34Broad metatarsal (HP:0001783)2.47972631
35Postural instability (HP:0002172)2.47880588
36Neurofibrillary tangles (HP:0002185)2.47791517
37Distal lower limb amyotrophy (HP:0008944)2.45873251
38Hand muscle atrophy (HP:0009130)2.44345832
39Rapidly progressive (HP:0003678)2.42517047
40Hemiplegia (HP:0002301)2.41809230
41Increased variability in muscle fiber diameter (HP:0003557)2.41651473
42Myopathic facies (HP:0002058)2.39714412
43Protrusio acetabuli (HP:0003179)2.36315224
44Macroorchidism (HP:0000053)2.35582750
45Prolonged QT interval (HP:0001657)2.32508806
46Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.32346929
47Abnormality of the Achilles tendon (HP:0005109)2.30979349
48Lymphangioma (HP:0100764)2.28674584
49Urinary bladder sphincter dysfunction (HP:0002839)2.23720978
50Torticollis (HP:0000473)2.21620832
51Intention tremor (HP:0002080)2.20886639
52Abnormal social behavior (HP:0012433)2.16340658
53Impaired social interactions (HP:0000735)2.16340658
54Urinary urgency (HP:0000012)2.14786123
55Elfin facies (HP:0004428)2.14227606
56Distal lower limb muscle weakness (HP:0009053)2.13938736
57Cellulitis (HP:0100658)2.13245429
58Spastic gait (HP:0002064)2.12133694
59Genetic anticipation (HP:0003743)2.11146522
60Dysdiadochokinesis (HP:0002075)2.11000282
61Mildly elevated creatine phosphokinase (HP:0008180)2.10427910
62Ventricular arrhythmia (HP:0004308)2.08374319
63Increased IgE level (HP:0003212)2.06845175
64Shallow orbits (HP:0000586)2.06598326
65Papilledema (HP:0001085)2.06220317
66Atrial fibrillation (HP:0005110)2.05912340
67Lower limb amyotrophy (HP:0007210)2.05650257
68Epileptic encephalopathy (HP:0200134)2.04812206
69Exercise-induced muscle cramps (HP:0003710)2.04300850
70Primary atrial arrhythmia (HP:0001692)2.02981479
71Resting tremor (HP:0002322)2.02374440
72Syncope (HP:0001279)2.02181625
73Dysmetria (HP:0001310)2.02112836
74Generalized tonic-clonic seizures (HP:0002069)2.02063325
75Pointed chin (HP:0000307)2.01433737
76Hypercortisolism (HP:0001578)2.00258577
77Poor eye contact (HP:0000817)2.00175682
78Abnormal EKG (HP:0003115)2.00070970
79Mutism (HP:0002300)1.99542573
80Turricephaly (HP:0000262)1.97783555
81Progressive cerebellar ataxia (HP:0002073)1.97718438
82Hemiparesis (HP:0001269)1.97645286
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97131911
84Absence seizures (HP:0002121)1.95414207
85Anxiety (HP:0000739)1.93419287
86Foot dorsiflexor weakness (HP:0009027)1.92736904
87Abnormality of skeletal muscle fiber size (HP:0012084)1.92416285
88EMG: neuropathic changes (HP:0003445)1.91633628
89Overriding aorta (HP:0002623)1.91323063
90Neuronal loss in central nervous system (HP:0002529)1.91200485
91Impaired vibration sensation in the lower limbs (HP:0002166)1.91111994
92Spontaneous hematomas (HP:0007420)1.89234539
93Truncal ataxia (HP:0002078)1.88879287
94Growth hormone excess (HP:0000845)1.88161527
95Megalencephaly (HP:0001355)1.87842750
96Increased connective tissue (HP:0009025)1.87752162
97Onion bulb formation (HP:0003383)1.87358073
98Abnormality of the calf musculature (HP:0001430)1.86480702
99Myotonia (HP:0002486)1.86380801
100Myoglobinuria (HP:0002913)1.85783573
101Stridor (HP:0010307)1.85450596
102EMG: myopathic abnormalities (HP:0003458)1.85082435
103Hypoventilation (HP:0002791)1.84797800
104Supraventricular tachycardia (HP:0004755)1.84635865
105Muscle fiber splitting (HP:0003555)1.84248367
106Supraventricular arrhythmia (HP:0005115)1.83777385
107Ventricular tachycardia (HP:0004756)1.83631194
108Calf muscle hypertrophy (HP:0008981)1.82807992
109Lower limb muscle weakness (HP:0007340)1.82785399
110Round ear (HP:0100830)1.82470114
111Central scotoma (HP:0000603)1.81424374
112Focal dystonia (HP:0004373)1.81296686
113Dysostosis multiplex (HP:0000943)1.81282889
114Prolonged bleeding time (HP:0003010)1.80940684
115Disproportionate tall stature (HP:0001519)1.80447572
116Abnormality of the foot musculature (HP:0001436)1.79699098
117Aneurysm (HP:0002617)1.79118063
118Difficulty climbing stairs (HP:0003551)1.78578643
119Metaphyseal cupping (HP:0003021)1.77456354
120Asymmetric septal hypertrophy (HP:0001670)1.77338687
121Purpura (HP:0000979)1.77196268
122Hemorrhage of the eye (HP:0011885)1.76874274
123Muscle hypertrophy of the lower extremities (HP:0008968)1.76446616
124Sleep apnea (HP:0010535)1.76344932
125Renovascular hypertension (HP:0100817)1.75583724
126Apathy (HP:0000741)1.75211201
127Bladder diverticulum (HP:0000015)1.75185586
128Spinal canal stenosis (HP:0003416)1.75082443
129Bronchomalacia (HP:0002780)1.74954192
130Polygenic inheritance (HP:0010982)1.74764528
131Broad face (HP:0000283)1.74145699
132Bowel incontinence (HP:0002607)1.73907832
133Heart block (HP:0012722)1.72924448
134Renal duplication (HP:0000075)1.72921748
135Abnormal eating behavior (HP:0100738)1.71630626
136Rigidity (HP:0002063)1.70813627
137Atelectasis (HP:0100750)1.69873472
138Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68323603
139Gingivitis (HP:0000230)1.67676655
140Bulbar palsy (HP:0001283)1.65464302
141Decreased motor nerve conduction velocity (HP:0003431)1.63603982
142Amyloidosis (HP:0011034)1.62216956
143Polycythemia (HP:0001901)1.61959669
144Lower limb asymmetry (HP:0100559)1.61860315
145Spinal rigidity (HP:0003306)1.61847106
146Muscle fiber inclusion bodies (HP:0100299)1.61333920
147Segmental peripheral demyelination/remyelination (HP:0003481)1.60911281
148Abnormality of macrophages (HP:0004311)1.59124770
149Mitral regurgitation (HP:0001653)1.58307951
150Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.57828773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.37787203
2MAP3K92.78777679
3PRKD32.62540884
4PAK62.52258493
5INSRR2.49545233
6PKN22.39271127
7KSR22.28174143
8MAP3K112.25450319
9NTRK32.05574863
10RIPK12.02544081
11MARK12.00965549
12RIPK41.99465485
13MAP2K31.97199877
14MAP3K101.90893697
15NTRK11.86291193
16EPHA41.85407939
17PHKG21.83692032
18PHKG11.83692032
19CAMKK11.78215839
20TYRO31.71948138
21ICK1.71324379
22MAP4K11.65801703
23DAPK21.65051355
24TAOK11.59266287
25STK381.50288523
26ERN11.49089952
27SIK21.48472334
28TTN1.44828573
29MAP3K41.43932696
30CAMK1G1.43517441
31PDGFRA1.39577156
32NTRK21.38734903
33MINK11.36711324
34UHMK11.36398317
35MAP3K21.35507454
36PAK31.34807832
37DMPK1.31218676
38LMTK21.28770254
39PRKCH1.27179128
40WNK11.20099415
41SMG11.18150575
42RET1.17316414
43SIK11.15772257
44MAP3K61.13315441
45EEF2K1.11662179
46MAP2K41.11616336
47ALK1.11591175
48FGFR41.11494714
49STK111.11105640
50CDK51.10953111
51CDC42BPA1.06993212
52CAMK1D1.06035695
53GRK51.05734910
54MAP3K130.96432166
55KSR10.95386507
56PTK60.94999312
57BMX0.92343733
58TAOK20.90269260
59ZAP700.88703597
60TESK10.87209459
61LATS20.87151622
62BLK0.87092128
63MAP3K30.86737606
64FGFR20.86319109
65MAP3K10.80504500
66PDPK10.80202095
67DDR20.77883610
68PINK10.77801886
69* PRKD10.76999591
70RPS6KC10.75658356
71RPS6KL10.75658356
72HIPK20.75035520
73FGR0.74103910
74FES0.74023975
75PDK10.71317866
76HCK0.71122937
77TBK10.69695307
78EPHB10.69390196
79* MARK20.69387303
80TYK20.68269984
81SGK30.68097385
82CSK0.68067609
83NEK10.66863540
84SIK30.66117772
85PTK20.64048180
86DAPK30.61757204
87FER0.60923001
88CDK150.60836375
89ARAF0.60566967
90* DYRK1B0.60253061
91CAMKK20.60063014
92MAPK120.59971209
93CDK120.59318600
94PRPF4B0.59131226
95MTOR0.58079200
96* PRKD20.57501094
97WNK40.56936146
98RPS6KA20.56797621
99JAK20.56716457
100BTK0.56633462
101RPS6KA60.56245142
102SGK20.55764409
103MAP2K20.55200530
104CDK140.54841509
105CDK180.53893606
106SGK4940.53105828
107SGK2230.53105828
108SCYL20.52900370
109GRK60.52193640
110PRKG20.51357324
111CDK11A0.51161176
112MAPK40.51131510
113RPS6KA30.50329060
114ROCK10.50295024
115FYN0.50194321
116EPHA30.50163223
117CSF1R0.49025489
118PDGFRB0.48871237
119MAPK70.48660746
120ROCK20.47707458
121PRKCG0.47597435
122* MAP3K70.47315633
123PRKCZ0.46600249
124CDK190.46555251
125KIT0.45744143
126SYK0.45365139
127MATK0.45362382
128* PRKAA10.45087770
129OBSCN0.44050129
130JAK30.43816410
131IRAK40.43786398
132ERBB20.43458398
133PTK2B0.43311564
134SGK10.43106880
135TGFBR20.42690726
136* CAMK10.41728222
137MAPK100.41252938
138PAK20.40804788
139TNK20.38124390

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.37618849
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18733511
3Olfactory transduction_Homo sapiens_hsa047402.04801200
4Synaptic vesicle cycle_Homo sapiens_hsa047212.01166971
5GABAergic synapse_Homo sapiens_hsa047271.90638024
6Circadian entrainment_Homo sapiens_hsa047131.83699756
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75594614
8Insulin secretion_Homo sapiens_hsa049111.71847748
9Glutamatergic synapse_Homo sapiens_hsa047241.68826095
10Morphine addiction_Homo sapiens_hsa050321.61659569
11Long-term potentiation_Homo sapiens_hsa047201.60555004
12Salivary secretion_Homo sapiens_hsa049701.58179789
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57514809
14Other glycan degradation_Homo sapiens_hsa005111.57143233
15Type II diabetes mellitus_Homo sapiens_hsa049301.55990965
16Gastric acid secretion_Homo sapiens_hsa049711.55660027
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49245354
18Dilated cardiomyopathy_Homo sapiens_hsa054141.48259601
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47104317
20Notch signaling pathway_Homo sapiens_hsa043301.44195364
21Cholinergic synapse_Homo sapiens_hsa047251.41797428
22Oxytocin signaling pathway_Homo sapiens_hsa049211.41529316
23Dopaminergic synapse_Homo sapiens_hsa047281.41115614
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39298579
25Acute myeloid leukemia_Homo sapiens_hsa052211.38638670
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38627203
27Nicotine addiction_Homo sapiens_hsa050331.38074320
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37887481
29Renin secretion_Homo sapiens_hsa049241.34667676
30Amphetamine addiction_Homo sapiens_hsa050311.29700132
31GnRH signaling pathway_Homo sapiens_hsa049121.26632852
32Osteoclast differentiation_Homo sapiens_hsa043801.24928163
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23997990
34Cocaine addiction_Homo sapiens_hsa050301.23406329
35Gap junction_Homo sapiens_hsa045401.20452535
36B cell receptor signaling pathway_Homo sapiens_hsa046621.19217847
37Glioma_Homo sapiens_hsa052141.17964860
38Estrogen signaling pathway_Homo sapiens_hsa049151.17014091
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15957996
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15016985
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14956169
42cAMP signaling pathway_Homo sapiens_hsa040241.10441844
43mTOR signaling pathway_Homo sapiens_hsa041501.10238954
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10115930
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.09692513
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.06841945
47Long-term depression_Homo sapiens_hsa047301.06215687
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03837572
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02974164
50Calcium signaling pathway_Homo sapiens_hsa040201.02846130
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01804488
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01197853
53Axon guidance_Homo sapiens_hsa043601.00217422
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00125774
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98800440
56Cardiac muscle contraction_Homo sapiens_hsa042600.96761212
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.95410190
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.94008690
59VEGF signaling pathway_Homo sapiens_hsa043700.93968696
60Dorso-ventral axis formation_Homo sapiens_hsa043200.93618265
61Bile secretion_Homo sapiens_hsa049760.93566720
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92128727
63Taste transduction_Homo sapiens_hsa047420.91073786
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90750540
65ErbB signaling pathway_Homo sapiens_hsa040120.90363068
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89009858
67Insulin signaling pathway_Homo sapiens_hsa049100.87528230
68Melanogenesis_Homo sapiens_hsa049160.84311853
69Serotonergic synapse_Homo sapiens_hsa047260.83239682
70Pancreatic secretion_Homo sapiens_hsa049720.83119531
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.82672604
72Renal cell carcinoma_Homo sapiens_hsa052110.82506522
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82311238
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81596147
75Non-small cell lung cancer_Homo sapiens_hsa052230.80550471
76Insulin resistance_Homo sapiens_hsa049310.80452021
77Prolactin signaling pathway_Homo sapiens_hsa049170.79591123
78Endocytosis_Homo sapiens_hsa041440.79120320
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79099855
80Glucagon signaling pathway_Homo sapiens_hsa049220.78803019
81Chemokine signaling pathway_Homo sapiens_hsa040620.78116830
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.77714156
83Tuberculosis_Homo sapiens_hsa051520.76569067
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75450692
85Choline metabolism in cancer_Homo sapiens_hsa052310.74972090
86Leishmaniasis_Homo sapiens_hsa051400.74559390
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74471280
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71426717
89AMPK signaling pathway_Homo sapiens_hsa041520.71166845
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.70626672
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69402497
92Endometrial cancer_Homo sapiens_hsa052130.69265924
93Pancreatic cancer_Homo sapiens_hsa052120.69176766
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68135511
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68103519
96MAPK signaling pathway_Homo sapiens_hsa040100.67954449
97Arginine biosynthesis_Homo sapiens_hsa002200.67105129
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.66754980
99HIF-1 signaling pathway_Homo sapiens_hsa040660.66666407
100Rap1 signaling pathway_Homo sapiens_hsa040150.65351700
101Focal adhesion_Homo sapiens_hsa045100.64698732
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64276318
103Thyroid hormone synthesis_Homo sapiens_hsa049180.63605157
104Salmonella infection_Homo sapiens_hsa051320.63172495
105Colorectal cancer_Homo sapiens_hsa052100.60781883
106Lysosome_Homo sapiens_hsa041420.60576753
107Vibrio cholerae infection_Homo sapiens_hsa051100.60106096
108Prion diseases_Homo sapiens_hsa050200.59478844
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59320544
110Butanoate metabolism_Homo sapiens_hsa006500.58808378
111Proteoglycans in cancer_Homo sapiens_hsa052050.57628016
112Phototransduction_Homo sapiens_hsa047440.57317444
113Lysine degradation_Homo sapiens_hsa003100.57045807
114Malaria_Homo sapiens_hsa051440.56960539
115Chronic myeloid leukemia_Homo sapiens_hsa052200.56316267
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55869406
117Inositol phosphate metabolism_Homo sapiens_hsa005620.54774736
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54735356
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51929499
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.51204604
121Platelet activation_Homo sapiens_hsa046110.50730663
122Ras signaling pathway_Homo sapiens_hsa040140.50552132
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50168156
124Tight junction_Homo sapiens_hsa045300.48274425
125Fatty acid biosynthesis_Homo sapiens_hsa000610.47068469
126Bladder cancer_Homo sapiens_hsa052190.42700226
127Amoebiasis_Homo sapiens_hsa051460.41620081
128Fatty acid metabolism_Homo sapiens_hsa012120.41549098

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