HCRTR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)7.88689725
2neurotransmitter catabolic process (GO:0042135)7.76325191
3behavioral response to ethanol (GO:0048149)7.11197410
4sympathetic nervous system development (GO:0048485)6.76586707
5fusion of sperm to egg plasma membrane (GO:0007342)6.40221871
6catecholamine transport (GO:0051937)6.16985018
7positive regulation of action potential (GO:0045760)5.89470400
8catechol-containing compound biosynthetic process (GO:0009713)5.78153276
9catecholamine biosynthetic process (GO:0042423)5.78153276
10dopamine metabolic process (GO:0042417)5.66253221
11positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.42233148
12plasma membrane fusion (GO:0045026)5.31199956
13synaptic transmission, cholinergic (GO:0007271)5.28617942
14dopamine biosynthetic process (GO:0042416)5.20594500
15neurotransmitter biosynthetic process (GO:0042136)5.13055872
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.06655446
17negative regulation of microtubule polymerization (GO:0031115)5.02475104
18positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.88249463
19norepinephrine metabolic process (GO:0042415)4.71830913
20regulation of short-term neuronal synaptic plasticity (GO:0048172)4.59522064
21oxygen transport (GO:0015671)4.52320049
22cell migration in hindbrain (GO:0021535)4.51854129
23neuromuscular synaptic transmission (GO:0007274)4.45205187
24synaptic vesicle exocytosis (GO:0016079)4.42014840
25alkaloid metabolic process (GO:0009820)4.41634836
26dopamine transport (GO:0015872)4.40892964
27adenosine receptor signaling pathway (GO:0001973)4.37583245
28neurotransmitter secretion (GO:0007269)4.36933477
29regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.32732572
30regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.32732572
31response to water (GO:0009415)4.32242125
32maternal behavior (GO:0042711)4.31747146
33response to pain (GO:0048265)4.27033299
34microtubule depolymerization (GO:0007019)4.18894989
35sialylation (GO:0097503)4.18627002
36neurotransmitter metabolic process (GO:0042133)4.18035773
37urinary tract smooth muscle contraction (GO:0014848)4.13220513
38catechol-containing compound metabolic process (GO:0009712)4.12235856
39catecholamine metabolic process (GO:0006584)4.12235856
40proline transport (GO:0015824)4.12031919
41layer formation in cerebral cortex (GO:0021819)4.07320017
42piRNA metabolic process (GO:0034587)4.03696335
43sperm motility (GO:0030317)3.92846037
44monoamine transport (GO:0015844)3.92088020
45cytoskeletal anchoring at plasma membrane (GO:0007016)3.91452637
46neurotransmitter transport (GO:0006836)3.91184535
47neuromuscular process controlling posture (GO:0050884)3.90975540
48phenol-containing compound biosynthetic process (GO:0046189)3.90710516
49synaptic transmission, dopaminergic (GO:0001963)3.90576555
50synaptic vesicle docking involved in exocytosis (GO:0016081)3.90369907
51regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.89112338
52serotonin metabolic process (GO:0042428)3.83973460
53negative regulation of neurotransmitter transport (GO:0051589)3.81980558
54regulation of catecholamine metabolic process (GO:0042069)3.80607350
55regulation of dopamine metabolic process (GO:0042053)3.80607350
56negative regulation of inclusion body assembly (GO:0090084)3.80022968
57regulation of neurotransmitter uptake (GO:0051580)3.78845147
58primary amino compound metabolic process (GO:1901160)3.78674745
59synaptic vesicle maturation (GO:0016188)3.77351076
60regulation of vesicle fusion (GO:0031338)3.77005066
61regulation of neurotransmitter levels (GO:0001505)3.76574973
62regulation of respiratory gaseous exchange (GO:0043576)3.75822769
63cellular response to nicotine (GO:0071316)3.74851214
64regulation of action potential (GO:0098900)3.74348725
65regulation of synaptic transmission, dopaminergic (GO:0032225)3.69361766
66parental behavior (GO:0060746)3.68084280
67DNA methylation involved in gamete generation (GO:0043046)3.68022444
68response to amphetamine (GO:0001975)3.61759954
69acrosome reaction (GO:0007340)3.61561777
70mating behavior (GO:0007617)3.61034478
71neuron cell-cell adhesion (GO:0007158)3.60142795
72neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.57591053
73regulation of neurotransmitter transport (GO:0051588)3.56360897
74regulation of cell communication by electrical coupling (GO:0010649)3.55969842
75neuronal action potential (GO:0019228)3.53841564
76glutamate secretion (GO:0014047)3.53095916
77detection of temperature stimulus involved in sensory perception (GO:0050961)3.49876421
78detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.49876421
79ionotropic glutamate receptor signaling pathway (GO:0035235)3.49389002
80positive regulation of neurotransmitter transport (GO:0051590)3.46047637
81cellular response to ATP (GO:0071318)3.41953012
82regulation of respiratory system process (GO:0044065)3.36569381
83histone H3-K9 demethylation (GO:0033169)3.36131017
84mature B cell differentiation involved in immune response (GO:0002313)3.36016685
85G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.34791629
86regulation of synaptic vesicle exocytosis (GO:2000300)3.31434882
87long-term memory (GO:0007616)3.29097829
88positive regulation of potassium ion transmembrane transport (GO:1901381)3.28925741
89regulation of neurotransmitter secretion (GO:0046928)3.26301725
90vocalization behavior (GO:0071625)3.26037502
91response to insecticide (GO:0017085)3.21299295
92spermatid nucleus differentiation (GO:0007289)3.19695821
93chromatin silencing (GO:0006342)3.16609709
94detection of temperature stimulus (GO:0016048)3.16121868
95cellular ketone body metabolic process (GO:0046950)3.13797366
96vesicle transport along microtubule (GO:0047496)3.12755867
97cerebral cortex neuron differentiation (GO:0021895)3.08913299
98spermatid development (GO:0007286)3.08350808
99regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.07914115
100adult feeding behavior (GO:0008343)3.07176787
101protein localization to synapse (GO:0035418)3.07112216
102regulation of interferon-beta biosynthetic process (GO:0045357)3.03982822
103single strand break repair (GO:0000012)3.02324485
104ATP hydrolysis coupled proton transport (GO:0015991)2.99605028
105energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.99605028
106positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.98855620
107microtubule severing (GO:0051013)2.96837198
108regulation of glutamate receptor signaling pathway (GO:1900449)2.96699728
109purinergic nucleotide receptor signaling pathway (GO:0035590)2.95284278
110membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.94141340
111activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.94110774
112response to nerve growth factor (GO:1990089)2.92827216
113cellular response to nerve growth factor stimulus (GO:1990090)2.92827216
114righting reflex (GO:0060013)2.92696753
115multicellular organismal response to stress (GO:0033555)2.92283894
116locomotory exploration behavior (GO:0035641)2.91346904
117positive regulation of vesicle fusion (GO:0031340)2.91238494
118positive regulation of synapse maturation (GO:0090129)2.90590750
119histone H3-K9 methylation (GO:0051567)2.90062386
120positive regulation of protein kinase C signaling (GO:0090037)2.89906445
121microtubule polymerization or depolymerization (GO:0031109)2.89607116
122multi-organism reproductive behavior (GO:0044705)2.88927243
123positive regulation of protein targeting to membrane (GO:0090314)2.85432807
124enteric nervous system development (GO:0048484)2.84481928
125dopaminergic neuron differentiation (GO:0071542)2.83791311
126fear response (GO:0042596)2.83542708
127regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.83491974
128negative regulation of gene expression, epigenetic (GO:0045814)2.83187393
129exploration behavior (GO:0035640)2.81874474
130adult behavior (GO:0030534)2.80672468
131mature B cell differentiation (GO:0002335)2.80435817
132response to nicotine (GO:0035094)2.80369494
133calcium-mediated signaling using intracellular calcium source (GO:0035584)2.80077901
134regulation of ARF protein signal transduction (GO:0032012)2.79425436
135calcium ion-dependent exocytosis (GO:0017156)2.78919346
136regulation of synaptic vesicle transport (GO:1902803)2.77756275
137purinergic receptor signaling pathway (GO:0035587)2.76619661
138cerebellar Purkinje cell differentiation (GO:0021702)2.76461894
139response to cocaine (GO:0042220)2.76166630
140positive regulation of membrane potential (GO:0045838)2.75757366
141regulation of Rab GTPase activity (GO:0032313)2.75721763
142positive regulation of Rab GTPase activity (GO:0032851)2.75721763
143regulation of synapse structural plasticity (GO:0051823)2.74099716
144toxin metabolic process (GO:0009404)2.73541263
145neuron-neuron synaptic transmission (GO:0007270)2.73155924
146regulation of calcium ion-dependent exocytosis (GO:0017158)2.72749457
147regulation of protein kinase A signaling (GO:0010738)2.72344820
148mannose metabolic process (GO:0006013)2.71695931
149DNA packaging (GO:0006323)2.68116030
150regulation of protein targeting to membrane (GO:0090313)2.67808201
151regulation of T-helper 2 cell differentiation (GO:0045628)2.67633084
152synaptic transmission, glutamatergic (GO:0035249)2.67195949
153regulation of acrosome reaction (GO:0060046)2.65375984
154negative regulation of cell aging (GO:0090344)2.64215629
155regulation of ARF GTPase activity (GO:0032312)2.63907888
156Golgi to plasma membrane protein transport (GO:0043001)2.63657080
157response to ATP (GO:0033198)2.62443537
158ketone body metabolic process (GO:1902224)2.61892335
159pericardium development (GO:0060039)2.60410933
160regulation of neuronal synaptic plasticity (GO:0048168)2.59209776
161male meiosis I (GO:0007141)2.58162651
162grooming behavior (GO:0007625)2.57674421
163positive regulation of heat generation (GO:0031652)2.55131161
164activation of protein kinase A activity (GO:0034199)2.53977462
165behavioral response to pain (GO:0048266)2.53505394
166glutamate receptor signaling pathway (GO:0007215)2.52192494
167regulation of skeletal muscle contraction (GO:0014819)2.50470677
168estrogen biosynthetic process (GO:0006703)2.50043937
169sex determination (GO:0007530)2.48924563
170histone H3-K9 modification (GO:0061647)2.46185836
171histone demethylation (GO:0016577)2.45043255
172positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.44500921
173sperm capacitation (GO:0048240)2.42956519
174seminiferous tubule development (GO:0072520)2.42515574
175sexual reproduction (GO:0019953)2.41792268
176positive regulation of systemic arterial blood pressure (GO:0003084)2.41417553
177positive regulation of neurotransmitter secretion (GO:0001956)2.41400752
178negative regulation of toll-like receptor signaling pathway (GO:0034122)2.41362547
179protein depolymerization (GO:0051261)2.40589024
180G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.40433986
181sensory perception of taste (GO:0050909)2.39350302
182rRNA methylation (GO:0031167)2.39349130
183negative regulation of cAMP-mediated signaling (GO:0043951)2.39142374
184G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.33005919
185phenol-containing compound catabolic process (GO:0019336)12.5277170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.42339984
2GBX2_23144817_ChIP-Seq_PC3_Human3.33881965
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.26415381
4TAF15_26573619_Chip-Seq_HEK293_Human3.10209398
5VDR_21846776_ChIP-Seq_THP-1_Human3.03801012
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03462196
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.86012960
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73116972
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.70498372
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67369357
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.63870672
12NR3C1_23031785_ChIP-Seq_PC12_Mouse2.57288985
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56130297
14* LXR_22292898_ChIP-Seq_THP-1_Human2.55038931
15REST_21632747_ChIP-Seq_MESCs_Mouse2.54678782
16* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49986316
17* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49986316
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47343782
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46093446
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43370843
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.41981946
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.39256551
23* EZH2_27304074_Chip-Seq_ESCs_Mouse2.38453819
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.33455466
25P68_20966046_ChIP-Seq_HELA_Human2.29184855
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22354297
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21363646
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.21054658
29AR_21572438_ChIP-Seq_LNCaP_Human2.16827100
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.09690003
31VDR_24763502_ChIP-Seq_THP-1_Human2.06648237
32SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04535575
33CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01831027
34SMC4_20622854_ChIP-Seq_HELA_Human1.97663725
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97406493
36KDM2B_26808549_Chip-Seq_DND41_Human1.96564531
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91492241
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.91372309
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86406925
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79837089
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.79302072
42MAF_26560356_Chip-Seq_TH2_Human1.79006608
43* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.76000332
44DROSHA_22980978_ChIP-Seq_HELA_Human1.74832851
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73540052
46P300_19829295_ChIP-Seq_ESCs_Human1.71646650
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.70157991
48SMAD4_21799915_ChIP-Seq_A2780_Human1.69439092
49TCF7_22412390_ChIP-Seq_EML_Mouse1.69074613
50E2F1_20622854_ChIP-Seq_HELA_Human1.66724804
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.64528877
52* BCL6_27268052_Chip-Seq_Bcells_Human1.64384862
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63065426
54KDM2B_26808549_Chip-Seq_K562_Human1.62281203
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.62115379
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.61314458
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60191808
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.59246552
59BCOR_27268052_Chip-Seq_Bcells_Human1.58387497
60* MAF_26560356_Chip-Seq_TH1_Human1.55201664
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53487580
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51821037
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49801977
64* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48959735
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48959306
66PHF8_20622854_ChIP-Seq_HELA_Human1.46346845
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.40219674
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38265186
69* ERA_21632823_ChIP-Seq_H3396_Human1.38087078
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36654104
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35464067
72OCT4_19829295_ChIP-Seq_ESCs_Human1.35404483
73BCAT_22108803_ChIP-Seq_LS180_Human1.35358175
74* TET1_21451524_ChIP-Seq_MESCs_Mouse1.34901647
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34588807
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.34373126
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.33437898
78UTX_26944678_Chip-Seq_JUKART_Human1.32525121
79IGF1R_20145208_ChIP-Seq_DFB_Human1.31897408
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.31576180
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30975211
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30701077
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30530717
84ELK4_26923725_Chip-Seq_MESODERM_Mouse1.29788984
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28948105
86AR_25329375_ChIP-Seq_VCAP_Human1.28441613
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.28182425
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27345868
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27163843
90* SA1_27219007_Chip-Seq_ERYTHROID_Human1.26521027
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25984233
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24917394
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24481654
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.24235032
95MYC_22102868_ChIP-Seq_BL_Human1.23750991
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23155801
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21321164
98FUS_26573619_Chip-Seq_HEK293_Human1.19210432
99* RAC3_21632823_ChIP-Seq_H3396_Human1.19046425
100ETS1_21867929_ChIP-Seq_TH2_Mouse1.19000170
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18828851
102RNF2_27304074_Chip-Seq_NSC_Mouse1.18733656
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17033009
104VDR_22108803_ChIP-Seq_LS180_Human1.16714312
105* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15943778
106* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.15863412
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14709082
108RUNX_20019798_ChIP-Seq_JUKART_Human1.13807373
109JUN_21703547_ChIP-Seq_K562_Human1.13490657
110GATA1_19941827_ChIP-Seq_MEL86_Mouse1.13290401
111ZNF274_21170338_ChIP-Seq_K562_Hela1.12763337
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12213989
113OCT4_20526341_ChIP-Seq_ESCs_Human1.11056746
114CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10499176
115* CTCF_21964334_Chip-Seq_Bcells_Human1.08767438
116* SA1_27219007_Chip-Seq_Bcells_Human1.08510542
117* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08352359
118STAT3_23295773_ChIP-Seq_U87_Human1.07927730
119PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07694199
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07550490
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07264406
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07179100
123CTCF_20526341_ChIP-Seq_ESCs_Human1.06922717
124RUNX2_22187159_ChIP-Seq_PCA_Human1.06852349
125PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06711300
126RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06678866
127ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06336843
128KLF4_19829295_ChIP-Seq_ESCs_Human1.06201764
129ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06179266
130* TET1_21490601_ChIP-Seq_MESCs_Mouse1.04972280
131VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04656768
132JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03642344
133CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03241436
134SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03191956
135CREB1_26743006_Chip-Seq_LNCaP_Human1.03005691
136RING1B_27294783_Chip-Seq_ESCs_Mouse1.02688611
137EP300_21415370_ChIP-Seq_HL-1_Mouse1.02250075
138RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02211696
139TP53_23651856_ChIP-Seq_MEFs_Mouse1.01777225
140* PRDM14_20953172_ChIP-Seq_ESCs_Human1.00806113
141GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00576048
142SCL_19346495_ChIP-Seq_HPC-7_Human1.00533959
143ER_23166858_ChIP-Seq_MCF-7_Human1.00134574
144* TP63_22573176_ChIP-Seq_HFKS_Human0.99518590
145SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99429621
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.97673179
147TCF4_23295773_ChIP-Seq_U87_Human0.96879238
148TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96241426
149SMAD_19615063_ChIP-ChIP_OVARY_Human0.96217016
150PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96124778
151DPY_21335234_ChIP-Seq_ESCs_Mouse0.96054616
152YY1_22570637_ChIP-Seq_MALME-3M_Human0.95608529
153WT1_19549856_ChIP-ChIP_CCG9911_Human0.93741424
154YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92620815
155* CTCF_27219007_Chip-Seq_Bcells_Human0.89525450
156TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89083257
157MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87781157
158ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86378961
159* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85465630
160AR_19668381_ChIP-Seq_PC3_Human0.85438770
161MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84669039
162WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84620668
163SMAD3_21741376_ChIP-Seq_ESCs_Human0.84304306
164HTT_18923047_ChIP-ChIP_STHdh_Human0.82985022
165KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82808002
166P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82197669
167NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80946926
168STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80064307
169TP53_18474530_ChIP-ChIP_U2OS_Human0.79095699
170CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78932987
171MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78553371

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy8.13343710
2MP0010386_abnormal_urinary_bladder4.05126333
3MP0006276_abnormal_autonomic_nervous3.87713665
4MP0001529_abnormal_vocalization3.77492812
5MP0003283_abnormal_digestive_organ3.68591748
6MP0002638_abnormal_pupillary_reflex3.64323011
7MP0001905_abnormal_dopamine_level3.44688105
8MP0001986_abnormal_taste_sensitivity3.32246476
9MP0004270_analgesia3.15548312
10MP0005410_abnormal_fertilization3.04290306
11MP0005174_abnormal_tail_pigmentation3.03575280
12MP0004859_abnormal_synaptic_plasticity3.03271408
13MP0001501_abnormal_sleep_pattern2.91100569
14MP0001440_abnormal_grooming_behavior2.85991467
15* MP0009745_abnormal_behavioral_response2.78824540
16MP0002734_abnormal_mechanical_nocicepti2.76308338
17MP0003635_abnormal_synaptic_transmissio2.76027334
18MP0004858_abnormal_nervous_system2.69024711
19MP0009278_abnormal_bone_marrow2.65906191
20MP0002733_abnormal_thermal_nociception2.57184904
21MP0001970_abnormal_pain_threshold2.51500038
22* MP0002064_seizures2.39290428
23MP0002572_abnormal_emotion/affect_behav2.32568088
24MP0004924_abnormal_behavior2.24345908
25MP0005386_behavior/neurological_phenoty2.24345908
26MP0009046_muscle_twitch2.23469986
27MP0002735_abnormal_chemical_nociception2.21966426
28MP0000538_abnormal_urinary_bladder2.21234058
29MP0008877_abnormal_DNA_methylation2.19542214
30MP0004130_abnormal_muscle_cell2.13507756
31MP0008872_abnormal_physiological_respon2.13468725
32MP0003880_abnormal_central_pattern2.12741481
33MP0008057_abnormal_DNA_replication2.10660939
34MP0002272_abnormal_nervous_system2.08998473
35MP0002063_abnormal_learning/memory/cond2.05282961
36MP0003303_peritoneal_inflammation2.04555306
37MP0005645_abnormal_hypothalamus_physiol2.04356256
38MP0001968_abnormal_touch/_nociception1.95296988
39MP0002751_abnormal_autonomic_nervous1.87914185
40MP0005171_absent_coat_pigmentation1.84883498
41MP0003122_maternal_imprinting1.80106836
42MP0004233_abnormal_muscle_weight1.70537117
43MP0008961_abnormal_basal_metabolism1.67101419
44MP0002184_abnormal_innervation1.63944399
45MP0005423_abnormal_somatic_nervous1.60458624
46MP0000015_abnormal_ear_pigmentation1.59472324
47MP0001188_hyperpigmentation1.58098206
48MP0000372_irregular_coat_pigmentation1.57093454
49MP0002067_abnormal_sensory_capabilities1.47814048
50MP0005646_abnormal_pituitary_gland1.45993690
51MP0001486_abnormal_startle_reflex1.45312429
52MP0004142_abnormal_muscle_tone1.43089469
53MP0003698_abnormal_male_reproductive1.42920068
54MP0000003_abnormal_adipose_tissue1.40041071
55MP0002557_abnormal_social/conspecific_i1.37255187
56MP0002736_abnormal_nociception_after1.35984498
57MP0004510_myositis1.27613187
58MP0002909_abnormal_adrenal_gland1.25207482
59MP0005666_abnormal_adipose_tissue1.25096795
60MP0008569_lethality_at_weaning1.24143553
61MP0009379_abnormal_foot_pigmentation1.22756531
62MP0005375_adipose_tissue_phenotype1.22101235
63MP0000778_abnormal_nervous_system1.18853577
64MP0004811_abnormal_neuron_physiology1.18563089
65MP0008004_abnormal_stomach_pH1.16438685
66MP0003633_abnormal_nervous_system1.15008249
67MP0000955_abnormal_spinal_cord1.14907631
68MP0008874_decreased_physiological_sensi1.14658410
69MP0001873_stomach_inflammation1.11984477
70MP0005535_abnormal_body_temperature1.11535565
71MP0002876_abnormal_thyroid_physiology1.11081071
72MP0005409_darkened_coat_color1.09096633
73MP0002066_abnormal_motor_capabilities/c1.07144211
74MP0005167_abnormal_blood-brain_barrier1.06630713
75MP0004484_altered_response_of1.05933778
76MP0003787_abnormal_imprinting1.05821010
77MP0003172_abnormal_lysosome_physiology1.03258700
78MP0002837_dystrophic_cardiac_calcinosis1.02608708
79MP0002882_abnormal_neuron_morphology1.02324429
80MP0001545_abnormal_hematopoietic_system1.01805777
81MP0005397_hematopoietic_system_phenotyp1.01805777
82MP0000604_amyloidosis1.01534931
83MP0003631_nervous_system_phenotype1.00730115
84MP0003075_altered_response_to1.00263134
85MP0001929_abnormal_gametogenesis0.99891675
86MP0005197_abnormal_uvea_morphology0.98619689
87MP0000751_myopathy0.96969061
88MP0003137_abnormal_impulse_conducting0.94355485
89MP0005451_abnormal_body_composition0.93075956
90MP0003828_pulmonary_edema0.91429427
91MP0000465_gastrointestinal_hemorrhage0.91274123
92MP0002163_abnormal_gland_morphology0.91017538
93MP0003221_abnormal_cardiomyocyte_apopto0.89506452
94MP0003436_decreased_susceptibility_to0.87602824
95MP0001756_abnormal_urination0.86331076
96MP0002127_abnormal_cardiovascular_syste0.86239089
97MP0004085_abnormal_heartbeat0.84412665
98MP0001664_abnormal_digestion0.83613133
99MP0003329_amyloid_beta_deposits0.83305738
100MP0000013_abnormal_adipose_tissue0.82920012
101MP0002928_abnormal_bile_duct0.81255792
102MP0005623_abnormal_meninges_morphology0.78778235
103MP0000569_abnormal_digit_pigmentation0.78164447
104MP0005464_abnormal_platelet_physiology0.77309553
105MP0002069_abnormal_eating/drinking_beha0.77243986
106MP0005083_abnormal_biliary_tract0.76884481
107MP0005058_abnormal_lysosome_morphology0.74814894
108MP0005499_abnormal_olfactory_system0.73015955
109MP0005394_taste/olfaction_phenotype0.73015955
110MP0001661_extended_life_span0.72974180
111MP0003879_abnormal_hair_cell0.71663455
112MP0005448_abnormal_energy_balance0.71565122
113MP0002752_abnormal_somatic_nervous0.70078191
114MP0008260_abnormal_autophagy0.68771402
115MP0002229_neurodegeneration0.68486276
116MP0005379_endocrine/exocrine_gland_phen0.68298502
117MP0004947_skin_inflammation0.68233455
118MP0003091_abnormal_cell_migration0.67729874
119MP0002152_abnormal_brain_morphology0.67513092
120MP0002090_abnormal_vision0.66534165
121MP0002161_abnormal_fertility/fecundity0.66403865
122MP0003646_muscle_fatigue0.65785478
123MP0005310_abnormal_salivary_gland0.64923253
124MP0005076_abnormal_cell_differentiation0.64153568
125MP0008995_early_reproductive_senescence0.63640033
126MP0001851_eye_inflammation0.62387346
127MP0001765_abnormal_ion_homeostasis0.61824158
128MP0004185_abnormal_adipocyte_glucose0.61461431
129MP0002210_abnormal_sex_determination0.60358531
130MP0001943_abnormal_respiration0.58944283
131MP0000747_muscle_weakness0.58658067
132MP0003632_abnormal_nervous_system0.58048566
133MP0002102_abnormal_ear_morphology0.56405105
134MP0002332_abnormal_exercise_endurance0.56232056
135MP0001348_abnormal_lacrimal_gland0.55437104
136MP0005551_abnormal_eye_electrophysiolog0.53543037
137MP0004883_abnormal_blood_vessel0.52213401
138MP0001963_abnormal_hearing_physiology0.51773443
139MP0003953_abnormal_hormone_level0.51684393
140MP0001502_abnormal_circadian_rhythm0.51161914
141MP0006072_abnormal_retinal_apoptosis0.50936332
142MP0001984_abnormal_olfaction0.48031084
143MP0004742_abnormal_vestibular_system0.47757739
144MP0003123_paternal_imprinting0.44988700
145MP0003045_fibrosis0.44736304
146MP0001340_abnormal_eyelid_morphology0.44701973
147MP0005085_abnormal_gallbladder_physiolo0.44547926
148MP0002160_abnormal_reproductive_system0.44420868
149MP0001299_abnormal_eye_distance/0.43682592
150MP0003638_abnormal_response/metabolism_0.43126116
151MP0003634_abnormal_glial_cell0.42812516
152MP0009780_abnormal_chondrocyte_physiolo0.42168700

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.14512247
2Orthostatic hypotension (HP:0001278)6.99605426
3Limb dystonia (HP:0002451)6.05503781
4Abnormal autonomic nervous system physiology (HP:0012332)5.80336165
5Fetal akinesia sequence (HP:0001989)5.11752130
6Neonatal hypoglycemia (HP:0001998)5.02221517
7Focal motor seizures (HP:0011153)4.58243596
8Focal seizures (HP:0007359)4.24327253
9Pheochromocytoma (HP:0002666)4.15826647
10Testicular atrophy (HP:0000029)4.12792705
11Visual hallucinations (HP:0002367)4.09010948
12Amblyopia (HP:0000646)4.01744915
13Annular pancreas (HP:0001734)3.97909874
14Neuroendocrine neoplasm (HP:0100634)3.85250297
15Progressive cerebellar ataxia (HP:0002073)3.81843926
16Facial hemangioma (HP:0000329)3.75411130
17Enlarged epiphyses (HP:0010580)3.65232136
18Atonic seizures (HP:0010819)3.63669933
19Exotropia (HP:0000577)3.61460968
20Attenuation of retinal blood vessels (HP:0007843)3.60308721
21Generalized tonic-clonic seizures (HP:0002069)3.56684961
22Hypoventilation (HP:0002791)3.46173273
23Turricephaly (HP:0000262)3.43719613
24Hyperthyroidism (HP:0000836)3.42881066
25Febrile seizures (HP:0002373)3.32489624
26Hypotension (HP:0002615)3.28679507
27Absence seizures (HP:0002121)3.22687146
28Capillary hemangiomas (HP:0005306)3.21604477
29Short chin (HP:0000331)3.20816795
30Autoamputation (HP:0001218)3.17629152
31Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.15876602
32Abnormal pupillary function (HP:0007686)3.12080251
33Bony spicule pigmentary retinopathy (HP:0007737)3.00506716
34Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.99502021
35Thin bony cortex (HP:0002753)2.98544372
36Myotonia (HP:0002486)2.97850468
37Poikiloderma (HP:0001029)2.90183767
38Chronic hepatic failure (HP:0100626)2.87479658
39Agitation (HP:0000713)2.86286534
40Intestinal fistula (HP:0100819)2.84259252
41Anxiety (HP:0000739)2.80951316
42Dialeptic seizures (HP:0011146)2.73796508
43Impaired pain sensation (HP:0007328)2.69591988
44Abnormality of pain sensation (HP:0010832)2.69591988
45Action tremor (HP:0002345)2.67889779
46Abnormality of the corticospinal tract (HP:0002492)2.67144005
47Abnormality of the hepatic vasculature (HP:0006707)2.66208498
48Truncal obesity (HP:0001956)2.64208467
49Postural instability (HP:0002172)2.63808616
50Azoospermia (HP:0000027)2.62175537
51Hypokinesia (HP:0002375)2.59722415
52Ankle clonus (HP:0011448)2.56034736
53Urinary urgency (HP:0000012)2.55337691
54Male infertility (HP:0003251)2.54998798
55Rectovaginal fistula (HP:0000143)2.53975301
56Rectal fistula (HP:0100590)2.53975301
57Acute necrotizing encephalopathy (HP:0006965)2.51483510
58Arthropathy (HP:0003040)2.50095474
59Supranuclear gaze palsy (HP:0000605)2.50057028
60Torticollis (HP:0000473)2.49336181
61Failure to thrive in infancy (HP:0001531)2.47091902
62Rib fusion (HP:0000902)2.45957188
63Malignant hyperthermia (HP:0002047)2.45116599
64Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.44886980
65Anteriorly placed anus (HP:0001545)2.44811688
66Postural tremor (HP:0002174)2.44752974
67Congenital stationary night blindness (HP:0007642)2.43589380
68Epileptic encephalopathy (HP:0200134)2.42198780
69Aplasia of the musculature (HP:0100854)2.40084355
70Craniofacial dystonia (HP:0012179)2.40065177
71Poor eye contact (HP:0000817)2.37868778
72Asymmetric septal hypertrophy (HP:0001670)2.36848100
73Poor suck (HP:0002033)2.36477765
74Termporal pattern (HP:0011008)2.32486865
75Insidious onset (HP:0003587)2.32486865
76Focal dystonia (HP:0004373)2.31930753
77Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.31229671
78Facial diplegia (HP:0001349)2.30003905
79Diplopia (HP:0000651)2.27800603
80Abnormality of binocular vision (HP:0011514)2.27800603
81Ulnar bowing (HP:0003031)2.26824213
82Abnormality of the costochondral junction (HP:0000919)2.26417012
83Abnormal mitochondria in muscle tissue (HP:0008316)2.26275294
84Vaginal fistula (HP:0004320)2.26248628
85Diminished movement (HP:0002374)2.24651466
86Polyphagia (HP:0002591)2.24590075
87Sensory axonal neuropathy (HP:0003390)2.21575441
88Protruding tongue (HP:0010808)2.20040029
89Joint stiffness (HP:0001387)2.19420310
90Choroideremia (HP:0001139)2.19024545
91External ophthalmoplegia (HP:0000544)2.18477854
92Infertility (HP:0000789)2.17492705
93Abnormality of the intrinsic pathway (HP:0010989)2.16758510
94Progressive macrocephaly (HP:0004481)2.14786755
95Resting tremor (HP:0002322)2.14446507
96Hemorrhage of the eye (HP:0011885)2.14180663
97Dysautonomia (HP:0002459)2.11368891
98Abnormality of aromatic amino acid family metabolism (HP:0004338)2.10841347
99Absent/shortened dynein arms (HP:0200106)2.10839863
100Dynein arm defect of respiratory motile cilia (HP:0012255)2.10839863
101Oligomenorrhea (HP:0000876)2.10616988
102Mutism (HP:0002300)2.10516221
103Increased neuronal autofluorescent lipopigment (HP:0002074)2.10048210
104Flat occiput (HP:0005469)2.09323731
105Abnormality of calcium-phosphate metabolism (HP:0100530)2.08590635
106Exercise-induced myalgia (HP:0003738)2.08573889
107Hypercortisolism (HP:0001578)2.08111822
108Depression (HP:0000716)2.08015116
109Clonus (HP:0002169)2.07089822
110Short humerus (HP:0005792)2.07014556
111Abnormal drinking behavior (HP:0030082)2.06418682
112Polydipsia (HP:0001959)2.06418682
113Psychosis (HP:0000709)2.05735574
114Mitochondrial inheritance (HP:0001427)2.05435204
115Spontaneous hematomas (HP:0007420)2.04889886
116Neuronal loss in central nervous system (HP:0002529)2.04875032
117Impulsivity (HP:0100710)2.04516259
118Increased cerebral lipofuscin (HP:0011813)2.01626265
119Urinary bladder sphincter dysfunction (HP:0002839)2.01316958
120Hypothermia (HP:0002045)11.8789981
121Abnormality of the fingertips (HP:0001211)1.99423960
122Neoplasm of the peripheral nervous system (HP:0100007)1.98907332
123Recurrent corneal erosions (HP:0000495)1.98498577
124Abnormality of the phalanges of the hallux (HP:0010057)1.98285472
125Genetic anticipation (HP:0003743)1.96628116
126Delusions (HP:0000746)1.96345817
127Emotional lability (HP:0000712)1.96303090
128Relative macrocephaly (HP:0004482)1.95707436
129Abnormal spermatogenesis (HP:0008669)1.95493100
130Aplasia/Hypoplasia of the brainstem (HP:0007362)1.95425887
131Hypoplasia of the brainstem (HP:0002365)1.95425887
132Thyroid carcinoma (HP:0002890)1.94210082
133Bradycardia (HP:0001662)1.92931875
134Neonatal onset (HP:0003623)1.92714796
135Aplasia/hypoplasia of the humerus (HP:0006507)1.91794182
136Amyotrophic lateral sclerosis (HP:0007354)1.91340918
137Mask-like facies (HP:0000298)1.91250142
138Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88924498
139Menstrual irregularities (HP:0000858)1.87623987
140Broad-based gait (HP:0002136)1.87377790
141Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.87011205
142Impaired vibration sensation in the lower limbs (HP:0002166)1.86938684
143Degeneration of the lateral corticospinal tracts (HP:0002314)1.86797339
144Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86797339
145Cerebral inclusion bodies (HP:0100314)1.86576981
146Severe visual impairment (HP:0001141)1.86244672
147Progressive inability to walk (HP:0002505)1.84631729
148Upper motor neuron abnormality (HP:0002127)1.83522267
149Abnormality of the distal phalanx of the thumb (HP:0009617)1.83425466
150Papilledema (HP:0001085)1.83165848
151Acute encephalopathy (HP:0006846)1.83009268
152Impaired smooth pursuit (HP:0007772)1.82794990
153Renal Fanconi syndrome (HP:0001994)1.82381373
154Widely patent fontanelles and sutures (HP:0004492)1.82259985
155Morphological abnormality of the pyramidal tract (HP:0002062)1.81933025
156Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80309585
157Popliteal pterygium (HP:0009756)1.79973370
158Abnormal hair whorl (HP:0010721)1.79590025
159Zonular cataract (HP:0010920)1.78746127
160Epileptiform EEG discharges (HP:0011182)1.78517583
161Abnormality of dental color (HP:0011073)1.77557021
162Joint hemorrhage (HP:0005261)1.77416867
163EEG with generalized epileptiform discharges (HP:0011198)1.77102263
164Difficulty walking (HP:0002355)1.77061685
165Abnormal eating behavior (HP:0100738)1.76574643
166Ulnar claw (HP:0001178)1.76464786
167Akinesia (HP:0002304)1.75896149
168Truncal ataxia (HP:0002078)1.75855518
169Spastic gait (HP:0002064)1.75696760
170Portal hypertension (HP:0001409)1.73864514
171Neurofibrillary tangles (HP:0002185)1.73733301
172Decreased central vision (HP:0007663)1.73564727
173Dysmetria (HP:0001310)1.72850693
174Specific learning disability (HP:0001328)1.70106174
175Muscular hypotonia of the trunk (HP:0008936)1.68799585
176Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.68416483
177Neuroblastoma (HP:0003006)1.68416483
178Primitive neuroectodermal tumor (HP:0030065)1.68416483
179Neuroblastic tumors (HP:0004376)1.68416483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK14.87194783
2GRK74.85461761
3MAP3K43.66968539
4NTRK33.45615823
5MAP3K123.26081413
6GRK53.11355073
7MAP2K73.10103144
8MAPK152.96380138
9MATK2.44775822
10MINK12.37518352
11CDK122.34318105
12MARK12.24753252
13MAP2K42.24706266
14CASK2.11705533
15MAPKAPK52.06717048
16CSNK1G32.01235285
17PKN21.96699041
18TIE11.96692468
19FLT31.89930724
20BLK1.89833075
21PNCK1.82932763
22CSNK1G21.79260528
23MAP3K91.77254672
24NTRK21.73662493
25ADRBK11.73306857
26ARAF1.67496104
27PDK11.64211806
28DAPK21.63458853
29PDPK11.61946662
30MARK21.61802517
31RIPK41.58411487
32CAMK1G1.50490862
33PLK21.45163101
34MAPK121.43617654
35UHMK11.43332384
36MAP3K111.41948008
37MAP2K11.36750020
38STK381.35221139
39PIK3CG1.33633112
40LIMK11.33512557
41CSNK1G11.32725168
42BRD41.30335412
43MAP2K61.29195979
44TGFBR21.22147720
45ICK1.20426249
46MAPK131.17463485
47MAP4K21.17011751
48ERN11.14727560
49TSSK61.13642748
50NME11.13532828
51LATS21.13401499
52MAP2K31.12444429
53CCNB11.12281367
54PRKD31.11273073
55CAMK2A1.09213644
56KSR21.06972439
57GRK61.05408165
58MAP3K131.05360384
59RIPK11.03813911
60DDR21.03015879
61PRKCG1.01662800
62CDK51.00003882
63CAMK2B0.99739150
64PAK60.99027341
65PRKCE0.97864284
66TESK20.95717143
67CDK190.94665152
68FGR0.92613637
69PHKG10.91789398
70PHKG20.91789398
71DAPK10.90301355
72DYRK1B0.89801411
73WNK10.88889039
74CAMKK20.88483251
75TAOK10.87544144
76KIT0.87438735
77MAP3K20.87403720
78CDK180.85453008
79MAPK110.84056281
80TYRO30.83334975
81CDK150.83191060
82SGK4940.82585580
83SGK2230.82585580
84STK390.82527883
85CDK140.82223582
86CAMK1D0.82175032
87PTK2B0.80591665
88ZAP700.80513481
89CAMK2G0.80200291
90TRIM280.79793572
91PDK20.79581792
92OXSR10.79172006
93CAMK2D0.77286443
94MAP3K70.76533765
95LMTK20.74020351
96WNK40.72970678
97CDK11A0.72679181
98MYLK0.70077430
99RPS6KA20.69869922
100PAK30.69485296
101NEK60.69334096
102SIK30.68586197
103ADRBK20.67776802
104RAF10.67396051
105RET0.65695447
106TTN0.65415347
107CAMKK10.63709029
108MAPK70.63352903
109PRKD20.62929349
110SCYL20.62719430
111SYK0.61974685
112MAP3K60.60795410
113CAMK10.60724963
114PLK40.60591684
115AKT30.57918029
116MOS0.56470103
117TRIB30.55414012
118HCK0.53298227
119RPS6KA60.52883531
120INSRR0.52442880
121BMPR1B0.48390777
122PRKAA10.48106192
123MTOR0.48081600
124EPHA40.47251914
125PRKACA0.46503884
126DAPK30.46103592
127CSNK1E0.45457594
128TNIK0.44112571
129CSNK1A1L0.43760707
130RPS6KC10.42529074
131RPS6KL10.42529074
132SGK10.42489676
133SGK30.42440695
134PRPF4B0.42350140
135BCR0.42006877
136TBK10.41903307
137MAPK40.41538540
138DYRK20.40949562
139PIM20.40596916
140IRAK20.39588356
141PRKCB0.38657456
142TESK10.38526407
143KDR0.38518541
144FES0.37923319
145SGK20.37083990
146CAMK40.36990305
147PTK20.36509491
148SIK20.36081111
149CDC42BPA0.35690797
150STK110.35689493
151ERBB20.35552072
152PRKACG0.31415545
153BUB10.30911562
154WNK30.30631329
155ROCK20.30456728
156DYRK1A0.30193290
157NEK10.29624561
158PRKCH0.28029329
159FYN0.26901101
160PRKCA0.24294876

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.64237511
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.56845156
3Tyrosine metabolism_Homo sapiens_hsa003503.38486084
4Phenylalanine metabolism_Homo sapiens_hsa003603.25026642
5Cocaine addiction_Homo sapiens_hsa050302.92770165
6Oxidative phosphorylation_Homo sapiens_hsa001902.61569408
7Collecting duct acid secretion_Homo sapiens_hsa049662.61521335
8Amphetamine addiction_Homo sapiens_hsa050312.59675659
9Serotonergic synapse_Homo sapiens_hsa047262.54949404
10Parkinsons disease_Homo sapiens_hsa050122.41179623
11Nicotine addiction_Homo sapiens_hsa050332.38440651
12Dopaminergic synapse_Homo sapiens_hsa047282.37798445
13Cholinergic synapse_Homo sapiens_hsa047252.29629316
14Histidine metabolism_Homo sapiens_hsa003402.11777900
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.06015013
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.05958305
17Olfactory transduction_Homo sapiens_hsa047402.01865604
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90746652
19Circadian entrainment_Homo sapiens_hsa047131.80477709
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79372619
21Alzheimers disease_Homo sapiens_hsa050101.79115892
22Long-term depression_Homo sapiens_hsa047301.72164127
23Taste transduction_Homo sapiens_hsa047421.71413271
24Salivary secretion_Homo sapiens_hsa049701.68998526
25Vibrio cholerae infection_Homo sapiens_hsa051101.68526210
26GABAergic synapse_Homo sapiens_hsa047271.66377064
27Glutamatergic synapse_Homo sapiens_hsa047241.63108742
28Renin secretion_Homo sapiens_hsa049241.61587500
29Insulin secretion_Homo sapiens_hsa049111.58449900
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52469854
31Morphine addiction_Homo sapiens_hsa050321.45770116
32Long-term potentiation_Homo sapiens_hsa047201.40772384
33Huntingtons disease_Homo sapiens_hsa050161.36443338
34* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35426902
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33375849
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33257188
37Gap junction_Homo sapiens_hsa045401.30405487
38Tryptophan metabolism_Homo sapiens_hsa003801.28352623
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28126363
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.27644577
41Gastric acid secretion_Homo sapiens_hsa049711.25380531
42GnRH signaling pathway_Homo sapiens_hsa049121.19771652
43Calcium signaling pathway_Homo sapiens_hsa040201.19314171
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17672709
45Circadian rhythm_Homo sapiens_hsa047101.15598053
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14616062
47Cardiac muscle contraction_Homo sapiens_hsa042601.13707041
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12962274
49mTOR signaling pathway_Homo sapiens_hsa041501.09915005
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07270913
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07062716
52VEGF signaling pathway_Homo sapiens_hsa043701.05589252
53Sulfur relay system_Homo sapiens_hsa041221.03958597
54Acute myeloid leukemia_Homo sapiens_hsa052211.01683616
55Proteasome_Homo sapiens_hsa030501.01291753
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00444578
57Platelet activation_Homo sapiens_hsa046110.96029678
58Oxytocin signaling pathway_Homo sapiens_hsa049210.94827102
59Dorso-ventral axis formation_Homo sapiens_hsa043200.88949306
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88532147
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87049986
62Alcoholism_Homo sapiens_hsa050340.83598974
63Other glycan degradation_Homo sapiens_hsa005110.83568649
64Phagosome_Homo sapiens_hsa041450.83213679
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.81676987
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81589597
67Butanoate metabolism_Homo sapiens_hsa006500.80725114
68Pancreatic secretion_Homo sapiens_hsa049720.78244378
69Non-small cell lung cancer_Homo sapiens_hsa052230.77892429
70cAMP signaling pathway_Homo sapiens_hsa040240.76815517
71Estrogen signaling pathway_Homo sapiens_hsa049150.76433296
72Endocytosis_Homo sapiens_hsa041440.76242771
73Fatty acid biosynthesis_Homo sapiens_hsa000610.74652129
74Fructose and mannose metabolism_Homo sapiens_hsa000510.72684310
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72669882
76Arginine and proline metabolism_Homo sapiens_hsa003300.72571054
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71095752
78Osteoclast differentiation_Homo sapiens_hsa043800.70778699
79Rheumatoid arthritis_Homo sapiens_hsa053230.69682319
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68640886
81Tuberculosis_Homo sapiens_hsa051520.67950744
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67945253
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67308877
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66594161
85Bile secretion_Homo sapiens_hsa049760.66423389
86Axon guidance_Homo sapiens_hsa043600.65827117
87Thyroid hormone synthesis_Homo sapiens_hsa049180.65823312
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65055336
89Fatty acid elongation_Homo sapiens_hsa000620.64004575
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63953861
91Melanogenesis_Homo sapiens_hsa049160.63391188
92African trypanosomiasis_Homo sapiens_hsa051430.63228886
93Phototransduction_Homo sapiens_hsa047440.62427962
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61761057
95TNF signaling pathway_Homo sapiens_hsa046680.61235458
96Hedgehog signaling pathway_Homo sapiens_hsa043400.60219199
97B cell receptor signaling pathway_Homo sapiens_hsa046620.60107511
98Arginine biosynthesis_Homo sapiens_hsa002200.55350367
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53616391
100Chemokine signaling pathway_Homo sapiens_hsa040620.53608246
101Ovarian steroidogenesis_Homo sapiens_hsa049130.52991854
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52854545
103Type II diabetes mellitus_Homo sapiens_hsa049300.52604075
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52212179
105Lysosome_Homo sapiens_hsa041420.51542052
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51053053
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49615382
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48617394
109T cell receptor signaling pathway_Homo sapiens_hsa046600.47793897
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45946754
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45742358
112Toxoplasmosis_Homo sapiens_hsa051450.45669340
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45297149
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44792268
115Rap1 signaling pathway_Homo sapiens_hsa040150.44409699
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.43649951
117Selenocompound metabolism_Homo sapiens_hsa004500.43646122
118Pertussis_Homo sapiens_hsa051330.43565011
119Pyruvate metabolism_Homo sapiens_hsa006200.43055847
120Amoebiasis_Homo sapiens_hsa051460.42993170
121Glucagon signaling pathway_Homo sapiens_hsa049220.42356745
122Prion diseases_Homo sapiens_hsa050200.41844016
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.39729968
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39513899
125ErbB signaling pathway_Homo sapiens_hsa040120.37909275
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.37637290
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.36656427
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36150692
129Steroid biosynthesis_Homo sapiens_hsa001000.34454817
130Dilated cardiomyopathy_Homo sapiens_hsa054140.31247885
131MAPK signaling pathway_Homo sapiens_hsa040100.30895424
132Ether lipid metabolism_Homo sapiens_hsa005650.29682821
133Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29360963
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28703786
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27289090
136Ras signaling pathway_Homo sapiens_hsa040140.26223781
137Oocyte meiosis_Homo sapiens_hsa041140.25058665
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24531168
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23565772
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.21053521
141Glioma_Homo sapiens_hsa052140.20133302
142Choline metabolism in cancer_Homo sapiens_hsa052310.18336292
143Insulin signaling pathway_Homo sapiens_hsa049100.18268855
144Inositol phosphate metabolism_Homo sapiens_hsa005620.16812934

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