HCRT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tyrosine phosphorylation of STAT protein (GO:0007260)8.76568201
2regulation of female gonad development (GO:2000194)7.67099877
3ovulation cycle (GO:0042698)7.42677828
4regulation of bile acid biosynthetic process (GO:0070857)7.33933926
5pyrimidine nucleobase catabolic process (GO:0006208)6.80258819
6response to pheromone (GO:0019236)6.58299038
7negative regulation of protein tyrosine kinase activity (GO:0061099)6.07151875
8synaptic vesicle maturation (GO:0016188)5.86381601
9behavioral response to nicotine (GO:0035095)5.72527604
10nucleobase catabolic process (GO:0046113)5.45941588
11regulation of short-term neuronal synaptic plasticity (GO:0048172)5.24222587
12neuronal action potential propagation (GO:0019227)5.07996833
13neurotransmitter secretion (GO:0007269)4.92789138
14adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.85103893
15neurofilament cytoskeleton organization (GO:0060052)4.61577850
16oxygen transport (GO:0015671)4.58788312
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.52839432
18neuromuscular process controlling posture (GO:0050884)4.49864388
19neurotransmitter transport (GO:0006836)4.35627963
20negative regulation of execution phase of apoptosis (GO:1900118)4.33483708
21gamma-aminobutyric acid signaling pathway (GO:0007214)4.26187209
22polyamine biosynthetic process (GO:0006596)4.24014148
23regulation of neurotransmitter levels (GO:0001505)4.19796876
24short-term memory (GO:0007614)4.16957889
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.09074081
26regulation of synaptic vesicle exocytosis (GO:2000300)4.07739523
27synaptic vesicle exocytosis (GO:0016079)4.05998510
28ribonucleoprotein complex disassembly (GO:0032988)4.03891620
29neurotransmitter catabolic process (GO:0042135)3.98089672
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.96035143
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.95932591
32sequestering of actin monomers (GO:0042989)3.93557576
33axon ensheathment in central nervous system (GO:0032291)3.92069709
34central nervous system myelination (GO:0022010)3.92069709
35cerebellar Purkinje cell layer development (GO:0021680)3.91344859
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.83998037
37regulation of glutamate receptor signaling pathway (GO:1900449)3.83955711
38neuron cell-cell adhesion (GO:0007158)3.82528504
39glutamate secretion (GO:0014047)3.81948856
40organelle disassembly (GO:1903008)3.76842680
41neuron recognition (GO:0008038)3.72783996
42acrosome reaction (GO:0007340)3.70836296
43microtubule depolymerization (GO:0007019)3.69473957
44vocalization behavior (GO:0071625)3.68933718
45regulation of glutamate secretion (GO:0014048)3.67939137
46protein localization to cilium (GO:0061512)3.67112600
47cellular biogenic amine biosynthetic process (GO:0042401)3.66792711
48axonal fasciculation (GO:0007413)3.64347666
49positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.62611825
50calcium-mediated signaling using intracellular calcium source (GO:0035584)3.61162786
51regulation of vesicle fusion (GO:0031338)3.60412159
52amine biosynthetic process (GO:0009309)3.56002009
53locomotory exploration behavior (GO:0035641)3.54482566
54regulation of protein kinase A signaling (GO:0010738)3.52649213
55opioid receptor signaling pathway (GO:0038003)3.52421244
56neurotransmitter uptake (GO:0001504)3.46396543
57metallo-sulfur cluster assembly (GO:0031163)3.45522768
58iron-sulfur cluster assembly (GO:0016226)3.45522768
59establishment of mitochondrion localization (GO:0051654)3.42037084
60activation of protein kinase A activity (GO:0034199)3.40403434
61activation of Rac GTPase activity (GO:0032863)3.39583334
62positive regulation of amino acid transport (GO:0051957)3.39275309
63adult walking behavior (GO:0007628)3.38335107
64gamma-aminobutyric acid transport (GO:0015812)3.38280204
65presynaptic membrane assembly (GO:0097105)3.38141621
66vesicle transport along microtubule (GO:0047496)3.36714194
67isoprenoid biosynthetic process (GO:0008299)3.36706419
68transmission of nerve impulse (GO:0019226)3.30698754
69presynaptic membrane organization (GO:0097090)3.30309340
70negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.28379943
71positive regulation of mitochondrial fission (GO:0090141)3.27194596
72regulation of synaptic vesicle transport (GO:1902803)3.26898453
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.25845059
74regulation of neuronal synaptic plasticity (GO:0048168)3.24322021
75auditory behavior (GO:0031223)3.24096370
76regulation of neuron migration (GO:2001222)3.21698921
77glutamate receptor signaling pathway (GO:0007215)3.21652576
78protein polyglutamylation (GO:0018095)3.18093155
79long-term memory (GO:0007616)3.17850505
80proline transport (GO:0015824)3.15568588
81iron coordination entity transport (GO:1901678)3.14412362
82regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.13881797
83spermatid nucleus differentiation (GO:0007289)3.12088180
84positive regulation of oligodendrocyte differentiation (GO:0048714)3.08378260
85cholesterol biosynthetic process (GO:0006695)3.06785647
86regulation of female receptivity (GO:0045924)3.06203651
87synaptic transmission, glutamatergic (GO:0035249)3.06010704
88dendritic spine morphogenesis (GO:0060997)3.05643276
89* regulation of transmission of nerve impulse (GO:0051969)3.04588589
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04572635
91regulation of long-term neuronal synaptic plasticity (GO:0048169)3.02617223
92polyamine metabolic process (GO:0006595)3.00872315
93olfactory bulb development (GO:0021772)3.00138866
94glycine transport (GO:0015816)2.99986278
95mating behavior (GO:0007617)2.99513581
96regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.98994123
97cerebellar granule cell differentiation (GO:0021707)2.96646501
98protein localization to synapse (GO:0035418)2.96061454
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.94205010
100L-phenylalanine catabolic process (GO:0006559)2.94205010
101mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.93223623
102synaptic transmission, cholinergic (GO:0007271)2.92224666
103ATP synthesis coupled proton transport (GO:0015986)2.89244370
104energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89244370
105regulation of synapse structural plasticity (GO:0051823)2.89200701
106social behavior (GO:0035176)2.86846953
107intraspecies interaction between organisms (GO:0051703)2.86846953
108negative regulation of telomere maintenance (GO:0032205)2.86155391
109positive regulation of synaptic transmission, GABAergic (GO:0032230)2.85963591
110exploration behavior (GO:0035640)2.85554909
111response to amphetamine (GO:0001975)2.81970678
112amine catabolic process (GO:0009310)2.79148492
113cellular biogenic amine catabolic process (GO:0042402)2.79148492
114neural tube formation (GO:0001841)2.78814043
115neuron-neuron synaptic transmission (GO:0007270)2.78694790
116cell communication by electrical coupling (GO:0010644)2.78548113
117positive regulation of vesicle fusion (GO:0031340)2.73857409
118dendrite development (GO:0016358)2.72684271
119regulation of beta-amyloid formation (GO:1902003)2.72088641
120intraciliary transport (GO:0042073)2.71606620
121central nervous system projection neuron axonogenesis (GO:0021952)2.70532505
122layer formation in cerebral cortex (GO:0021819)2.70486570
123calcium ion-dependent exocytosis (GO:0017156)2.70455856
124substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.69098724
125substrate-independent telencephalic tangential migration (GO:0021826)2.69098724
126negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.68054720
127synaptic transmission, dopaminergic (GO:0001963)2.67586506
128establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67504208
129mitochondrion transport along microtubule (GO:0047497)2.67504208
130peroxisome fission (GO:0016559)2.66925717
131epithelial cilium movement (GO:0003351)2.66229016
132cochlea development (GO:0090102)2.65996013
133dendrite morphogenesis (GO:0048813)2.65536312
134membrane hyperpolarization (GO:0060081)2.65394292
135photoreceptor cell differentiation (GO:0046530)2.64064859
136eye photoreceptor cell differentiation (GO:0001754)2.64064859
137organelle transport along microtubule (GO:0072384)2.64022664
138sterol biosynthetic process (GO:0016126)2.63521498
139* regulation of excitatory postsynaptic membrane potential (GO:0060079)2.62977690
140succinate metabolic process (GO:0006105)2.62925886
141regulation of amyloid precursor protein catabolic process (GO:1902991)2.62914358
142head development (GO:0060322)2.62467707
143regulation of autophagic vacuole assembly (GO:2000785)2.62410495
144response to histamine (GO:0034776)2.62093801
145suckling behavior (GO:0001967)2.61900366
146ectodermal placode formation (GO:0060788)2.61101419
147hippocampus development (GO:0021766)2.60922183
148cerebellar Purkinje cell differentiation (GO:0021702)2.60418158
149* membrane depolarization (GO:0051899)2.59930062
150* neuropeptide signaling pathway (GO:0007218)2.58719361
151regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.58465867
152axoneme assembly (GO:0035082)2.57739970
153neuromuscular process controlling balance (GO:0050885)2.57543570
154postsynaptic membrane organization (GO:0001941)2.57519565
155synapse assembly (GO:0007416)2.57250386
156negative regulation of peptidyl-tyrosine phosphorylation (GO:0050732)2.57130088
157respiratory chain complex IV assembly (GO:0008535)2.57045158
158DNA integration (GO:0015074)2.56543767
159signal release (GO:0023061)2.56072538
160cellular potassium ion homeostasis (GO:0030007)2.55962220
161DNA double-strand break processing (GO:0000729)2.55563164
162response to mercury ion (GO:0046689)2.55050172
163neuron fate determination (GO:0048664)2.54547273
164cell migration in hindbrain (GO:0021535)2.54188724
165Arp2/3 complex-mediated actin nucleation (GO:0034314)2.54037846
166high-density lipoprotein particle remodeling (GO:0034375)2.53818778
167positive regulation of RNA splicing (GO:0033120)2.53699473
168sodium ion export (GO:0071436)2.52774925
169retinal ganglion cell axon guidance (GO:0031290)2.50667099
170regulation of development, heterochronic (GO:0040034)2.50416305
171inositol phosphate dephosphorylation (GO:0046855)2.48537254
172phosphorylated carbohydrate dephosphorylation (GO:0046838)2.48537254
173respiratory system process (GO:0003016)2.45788989
174spinal cord development (GO:0021510)2.44873706
175mechanosensory behavior (GO:0007638)2.44033513
176cytoskeleton-dependent intracellular transport (GO:0030705)2.43938100
177ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.43748636
178microtubule polymerization or depolymerization (GO:0031109)2.43385626
179regulation of action potential (GO:0098900)2.42853076
180inositol phosphate catabolic process (GO:0071545)2.42698112
181regulation of hexokinase activity (GO:1903299)2.39100051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.99633334
2IGF1R_20145208_ChIP-Seq_DFB_Human3.64261102
3TAF15_26573619_Chip-Seq_HEK293_Human3.37469823
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06235156
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00911450
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89702339
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76922385
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.67476019
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62606193
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59394105
11GBX2_23144817_ChIP-Seq_PC3_Human2.58975427
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58555892
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57885907
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57885907
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55934047
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43100989
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.42930822
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37934860
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.34725669
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.33677985
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.24370817
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22163036
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.20925176
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16990642
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16540892
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15239149
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14181609
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.11143140
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.09225407
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.02592696
31EZH2_27304074_Chip-Seq_ESCs_Mouse2.00270739
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97618666
33DROSHA_22980978_ChIP-Seq_HELA_Human1.97286936
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.96764282
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95511853
36RNF2_27304074_Chip-Seq_NSC_Mouse1.91456272
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.86258049
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.77665359
39IRF1_19129219_ChIP-ChIP_H3396_Human1.75666252
40SMAD4_21799915_ChIP-Seq_A2780_Human1.72963221
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.72825396
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.69374781
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68521565
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.64180664
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63846464
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63465428
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.63249419
48* TP53_22573176_ChIP-Seq_HFKS_Human1.59313524
49EWS_26573619_Chip-Seq_HEK293_Human1.57734475
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57538668
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57006979
52AR_21572438_ChIP-Seq_LNCaP_Human1.56422685
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56347545
54ZNF274_21170338_ChIP-Seq_K562_Hela1.55511149
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54345170
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.51765029
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51181611
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49452387
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.49066253
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.48356972
61CBP_20019798_ChIP-Seq_JUKART_Human1.48100163
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48100163
63P300_19829295_ChIP-Seq_ESCs_Human1.43193236
64FUS_26573619_Chip-Seq_HEK293_Human1.41477734
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.40005435
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.39616468
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.38394903
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37936896
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37231135
70JUN_21703547_ChIP-Seq_K562_Human1.37209932
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34509832
72MYC_18940864_ChIP-ChIP_HL60_Human1.34381402
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.34358654
74VDR_23849224_ChIP-Seq_CD4+_Human1.33142758
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31560052
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31417307
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.28776396
78ELK1_19687146_ChIP-ChIP_HELA_Human1.28659013
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27108946
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24209307
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.23750674
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.23681584
83GABP_19822575_ChIP-Seq_HepG2_Human1.21374486
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20431632
85NCOR_22424771_ChIP-Seq_293T_Human1.20087919
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19167770
87CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18762181
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16467396
89EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15858767
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15683366
91AR_25329375_ChIP-Seq_VCAP_Human1.14745783
92SOX2_19829295_ChIP-Seq_ESCs_Human1.13363201
93NANOG_19829295_ChIP-Seq_ESCs_Human1.13363201
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.12570086
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12509186
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11638789
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11383609
98* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10578457
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10377274
100SRF_21415370_ChIP-Seq_HL-1_Mouse1.10306059
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10280287
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09830583
103GATA3_21878914_ChIP-Seq_MCF-7_Human1.09825478
104TP53_16413492_ChIP-PET_HCT116_Human1.09629563
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08033417
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07711096
107MYC_19829295_ChIP-Seq_ESCs_Human1.07599976
108GATA1_26923725_Chip-Seq_HPCs_Mouse1.07145742
109SOX2_16153702_ChIP-ChIP_HESCs_Human1.06557630
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05283586
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.05283586
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04964276
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04490494
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03701489
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02752439
116BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02358907
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02021284
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01046710
119VDR_22108803_ChIP-Seq_LS180_Human1.00644083
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00247778
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.00158043
122KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99870854
123EGR1_19032775_ChIP-ChIP_M12_Human0.99863777
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98320993
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98310821
126RING1B_27294783_Chip-Seq_ESCs_Mouse0.96748376
127* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95264895
128FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95030266
129PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94476004
130HTT_18923047_ChIP-ChIP_STHdh_Human0.94299964
131MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94170378
132REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93890554
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93394174
134CTCF_27219007_Chip-Seq_Bcells_Human0.92500673
135MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91864063
136ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91500739
137HOXB7_26014856_ChIP-Seq_BT474_Human0.91259409
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91045890
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90711848
140TCF4_23295773_ChIP-Seq_U87_Human0.90442079
141CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89536693
142ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.89289034
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.88877014
144AR_19668381_ChIP-Seq_PC3_Human0.88322246
145ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88165173
146ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87928159
147POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87861396
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87308959
149AR_20517297_ChIP-Seq_VCAP_Human0.87127229
150WDR5_24793694_ChIP-Seq_LNCAP_Human0.86403067
151RUNX2_22187159_ChIP-Seq_PCA_Human0.85863859
152TET1_21490601_ChIP-Seq_MESCs_Mouse0.85784147
153LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85693643
154CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84873812
155RING1B_27294783_Chip-Seq_NPCs_Mouse0.84116055
156STAT3_23295773_ChIP-Seq_U87_Human0.83113604
157STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82810484
158ER_23166858_ChIP-Seq_MCF-7_Human0.77984060
159SMAD3_21741376_ChIP-Seq_ESCs_Human0.77368155
160ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75905123
161NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74997973

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.32550114
2MP0005187_abnormal_penis_morphology4.65531017
3MP0003315_abnormal_perineum_morphology4.51455326
4MP0004859_abnormal_synaptic_plasticity4.36941060
5MP0002734_abnormal_mechanical_nocicepti3.47427467
6MP0003635_abnormal_synaptic_transmissio3.40562519
7MP0009745_abnormal_behavioral_response3.35128605
8MP0002064_seizures3.24485859
9MP0000569_abnormal_digit_pigmentation3.07647234
10MP0001984_abnormal_olfaction2.74387442
11MP0003122_maternal_imprinting2.72543546
12MP0002063_abnormal_learning/memory/cond2.72533840
13MP0005423_abnormal_somatic_nervous2.69477468
14MP0004142_abnormal_muscle_tone2.68913319
15MP0002876_abnormal_thyroid_physiology2.66858804
16MP0004270_analgesia2.60627458
17MP0009046_muscle_twitch2.60590711
18MP0002733_abnormal_thermal_nociception2.42220905
19MP0006276_abnormal_autonomic_nervous2.41879092
20MP0001348_abnormal_lacrimal_gland2.33879517
21* MP0002272_abnormal_nervous_system2.33458494
22MP0001970_abnormal_pain_threshold2.29997173
23MP0001968_abnormal_touch/_nociception2.28422459
24MP0003329_amyloid_beta_deposits2.27740024
25MP0003123_paternal_imprinting2.20203630
26MP0001501_abnormal_sleep_pattern2.19695692
27MP0001440_abnormal_grooming_behavior2.05544945
28MP0000751_myopathy2.03385433
29MP0003787_abnormal_imprinting1.99857961
30MP0002572_abnormal_emotion/affect_behav1.99395653
31MP0001486_abnormal_startle_reflex1.98431957
32MP0003121_genomic_imprinting1.91208105
33MP0004885_abnormal_endolymph1.84715861
34MP0002067_abnormal_sensory_capabilities1.82502574
35MP0000613_abnormal_salivary_gland1.75430927
36MP0005645_abnormal_hypothalamus_physiol1.72603201
37MP0008057_abnormal_DNA_replication1.71937818
38MP0000920_abnormal_myelination1.68869268
39MP0009780_abnormal_chondrocyte_physiolo1.68774108
40MP0005499_abnormal_olfactory_system1.65124097
41MP0005394_taste/olfaction_phenotype1.65124097
42MP0003690_abnormal_glial_cell1.61868607
43MP0001299_abnormal_eye_distance/1.52792993
44MP0003011_delayed_dark_adaptation1.51507766
45MP0004145_abnormal_muscle_electrophysio1.49824272
46MP0000955_abnormal_spinal_cord1.49153779
47MP0003221_abnormal_cardiomyocyte_apopto1.46409386
48MP0000372_irregular_coat_pigmentation1.44386964
49MP0008995_early_reproductive_senescence1.44281500
50MP0002735_abnormal_chemical_nociception1.43390678
51MP0003634_abnormal_glial_cell1.40921586
52MP0008789_abnormal_olfactory_epithelium1.39136280
53MP0008877_abnormal_DNA_methylation1.39023223
54MP0005386_behavior/neurological_phenoty1.38832901
55MP0004924_abnormal_behavior1.38832901
56MP0000747_muscle_weakness1.37721081
57MP0010329_abnormal_lipoprotein_level1.36038968
58MP0002184_abnormal_innervation1.35345931
59MP0004742_abnormal_vestibular_system1.34967106
60MP0000049_abnormal_middle_ear1.34670307
61MP0004133_heterotaxia1.34166224
62MP0002638_abnormal_pupillary_reflex1.32095078
63MP0000604_amyloidosis1.31002288
64MP0003283_abnormal_digestive_organ1.26625196
65MP0002736_abnormal_nociception_after1.26055267
66* MP0002066_abnormal_motor_capabilities/c1.25817682
67MP0003567_abnormal_fetal_cardiomyocyte1.25316702
68MP0002229_neurodegeneration1.22383902
69MP0002909_abnormal_adrenal_gland1.22027320
70MP0002254_reproductive_system_inflammat1.21877413
71MP0008569_lethality_at_weaning1.21834718
72MP0002837_dystrophic_cardiac_calcinosis1.20126432
73MP0004147_increased_porphyrin_level1.16884050
74MP0005253_abnormal_eye_physiology1.16038578
75MP0000778_abnormal_nervous_system1.14641322
76MP0002882_abnormal_neuron_morphology1.13045464
77MP0002557_abnormal_social/conspecific_i1.12922136
78MP0004215_abnormal_myocardial_fiber1.11288805
79MP0002752_abnormal_somatic_nervous1.10686454
80MP0005084_abnormal_gallbladder_morpholo1.08887709
81MP0001905_abnormal_dopamine_level1.06198323
82MP0002928_abnormal_bile_duct1.05574137
83MP0003646_muscle_fatigue1.03535555
84MP0003633_abnormal_nervous_system1.02736574
85MP0006292_abnormal_olfactory_placode1.01799658
86MP0001188_hyperpigmentation1.01345773
87MP0002102_abnormal_ear_morphology1.01333465
88MP0003303_peritoneal_inflammation0.98289378
89MP0005085_abnormal_gallbladder_physiolo0.97357700
90MP0001529_abnormal_vocalization0.96311286
91MP0004043_abnormal_pH_regulation0.95674242
92MP0003631_nervous_system_phenotype0.94960797
93MP0003632_abnormal_nervous_system0.92608047
94MP0010386_abnormal_urinary_bladder0.92169440
95MP0000631_abnormal_neuroendocrine_gland0.91209365
96MP0008875_abnormal_xenobiotic_pharmacok0.90235044
97MP0001502_abnormal_circadian_rhythm0.89412945
98MP0002090_abnormal_vision0.87833290
99MP0002332_abnormal_exercise_endurance0.87500544
100MP0002069_abnormal_eating/drinking_beha0.83338934
101MP0002160_abnormal_reproductive_system0.83138648
102MP0005083_abnormal_biliary_tract0.82577769
103MP0004811_abnormal_neuron_physiology0.82281673
104MP0005195_abnormal_posterior_eye0.82044161
105MP0001986_abnormal_taste_sensitivity0.81226476
106MP0005360_urolithiasis0.80933508
107MP0002139_abnormal_hepatobiliary_system0.79830277
108MP0006072_abnormal_retinal_apoptosis0.79766934
109MP0002210_abnormal_sex_determination0.79613648
110MP0005410_abnormal_fertilization0.78879751
111MP0002152_abnormal_brain_morphology0.78233575
112* MP0005535_abnormal_body_temperature0.78150857
113MP0008872_abnormal_physiological_respon0.76543379
114MP0002751_abnormal_autonomic_nervous0.74306633
115MP0005330_cardiomyopathy0.73761565
116MP0005389_reproductive_system_phenotype0.71885604
117MP0003195_calcinosis0.69808255
118MP0005365_abnormal_bile_salt0.68137150
119MP0000750_abnormal_muscle_regeneration0.67916945
120MP0003698_abnormal_male_reproductive0.66979393
121MP0002822_catalepsy0.66581267
122MP0003137_abnormal_impulse_conducting0.66405016
123MP0004782_abnormal_surfactant_physiolog0.65716212
124MP0001963_abnormal_hearing_physiology0.64968008
125MP0003718_maternal_effect0.64869781
126MP0001929_abnormal_gametogenesis0.63987410
127MP0006035_abnormal_mitochondrial_morpho0.63770623
128MP0004036_abnormal_muscle_relaxation0.63498976
129MP0004858_abnormal_nervous_system0.63297280
130MP0005551_abnormal_eye_electrophysiolog0.63130377
131MP0008874_decreased_physiological_sensi0.62988824
132MP0003119_abnormal_digestive_system0.61959372
133MP0009840_abnormal_foam_cell0.61830958
134MP0005452_abnormal_adipose_tissue0.60694640
135* MP0004085_abnormal_heartbeat0.59751921
136MP0005646_abnormal_pituitary_gland0.59382331
137MP0002234_abnormal_pharynx_morphology0.55858454
138MP0005623_abnormal_meninges_morphology0.55823668
139MP0002118_abnormal_lipid_homeostasis0.54155514

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.37203531
2Atonic seizures (HP:0010819)5.14122328
3Limb dystonia (HP:0002451)4.76028796
4Epileptic encephalopathy (HP:0200134)4.60511756
5Anosmia (HP:0000458)4.35225003
6Neurofibrillary tangles (HP:0002185)4.34353905
7Supranuclear gaze palsy (HP:0000605)4.22780415
8Focal seizures (HP:0007359)4.06753449
9Pheochromocytoma (HP:0002666)4.03800647
10Retinal dysplasia (HP:0007973)3.79245972
11Visual hallucinations (HP:0002367)3.76608700
12Generalized tonic-clonic seizures (HP:0002069)3.75085711
13Neuroendocrine neoplasm (HP:0100634)3.72438510
14Chronic hepatic failure (HP:0100626)3.61040669
15Cerebral inclusion bodies (HP:0100314)3.60161919
16Progressive cerebellar ataxia (HP:0002073)3.50910998
17Anxiety (HP:0000739)3.39994601
18Broad-based gait (HP:0002136)3.38244253
19Absence seizures (HP:0002121)3.37967030
20Agitation (HP:0000713)3.31388468
21Amblyopia (HP:0000646)3.21745614
22Dialeptic seizures (HP:0011146)3.20566123
23Lissencephaly (HP:0001339)3.19169526
24Delayed puberty (HP:0000823)3.14118909
25Dysmetria (HP:0001310)3.13514747
26Aplasia/Hypoplasia of the brainstem (HP:0007362)3.07439519
27Hypoplasia of the brainstem (HP:0002365)3.07439519
28Abnormality of the labia minora (HP:0012880)3.06980194
29Focal motor seizures (HP:0011153)3.05891716
30Urinary urgency (HP:0000012)3.04998530
31Poor suck (HP:0002033)3.04392130
32Polyphagia (HP:0002591)3.03778049
33Neuronal loss in central nervous system (HP:0002529)3.02857850
34Failure to thrive in infancy (HP:0001531)2.97841385
35Medial flaring of the eyebrow (HP:0010747)2.95293953
36Depression (HP:0000716)2.95217225
37Progressive inability to walk (HP:0002505)2.95136632
38Narrow nasal bridge (HP:0000446)2.89562313
39Hypogonadotrophic hypogonadism (HP:0000044)2.88624385
40Abnormality of midbrain morphology (HP:0002418)2.87291834
41Molar tooth sign on MRI (HP:0002419)2.87291834
42Infantile muscular hypotonia (HP:0008947)2.83072596
43Mutism (HP:0002300)2.79951695
44Abnormality of the corticospinal tract (HP:0002492)2.79159954
45Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.75405801
46Delusions (HP:0000746)2.75383401
47Ankle clonus (HP:0011448)2.74757996
48Abnormal eating behavior (HP:0100738)2.73921237
49Drooling (HP:0002307)2.73855841
50Excessive salivation (HP:0003781)2.73855841
51Urinary bladder sphincter dysfunction (HP:0002839)2.73826340
52Acute necrotizing encephalopathy (HP:0006965)2.73392293
53Cerebral hemorrhage (HP:0001342)2.71529144
54Pancreatic cysts (HP:0001737)2.70704160
55Gait imbalance (HP:0002141)2.70525915
56Restlessness (HP:0000711)2.69917044
57Nephronophthisis (HP:0000090)2.69624543
58Hyperventilation (HP:0002883)2.69190313
59Nephrogenic diabetes insipidus (HP:0009806)2.68220818
60Impaired vibration sensation in the lower limbs (HP:0002166)2.67741588
61Conjugated hyperbilirubinemia (HP:0002908)2.67236382
62Renal Fanconi syndrome (HP:0001994)2.63016695
63Congenital primary aphakia (HP:0007707)2.62908514
64True hermaphroditism (HP:0010459)2.62615945
65Hypsarrhythmia (HP:0002521)2.62325628
66EEG with generalized epileptiform discharges (HP:0011198)2.61118354
67Mitochondrial inheritance (HP:0001427)2.57150424
68Epileptiform EEG discharges (HP:0011182)2.55594200
69Psychosis (HP:0000709)2.54803778
70CNS hypomyelination (HP:0003429)2.54404867
71Generalized hypotonia (HP:0001290)2.52072228
72Spastic gait (HP:0002064)2.48962320
73Abnormality of aromatic amino acid family metabolism (HP:0004338)2.47963407
74Myotonia (HP:0002486)2.47228569
75Ventricular fibrillation (HP:0001663)2.47160678
76Abnormal mitochondria in muscle tissue (HP:0008316)2.46705300
77Truncal ataxia (HP:0002078)2.45797841
78Clumsiness (HP:0002312)2.45196460
79Pachygyria (HP:0001302)2.42205934
80Febrile seizures (HP:0002373)2.42202682
81Sleep apnea (HP:0010535)2.40605050
82Stenosis of the external auditory canal (HP:0000402)2.39558408
83Neoplasm of the peripheral nervous system (HP:0100007)2.39035735
84Gout (HP:0001997)2.38958075
85Acute encephalopathy (HP:0006846)2.37220376
86Type II lissencephaly (HP:0007260)2.36225440
87Delayed CNS myelination (HP:0002188)2.36134625
88Pancreatic fibrosis (HP:0100732)2.33889645
89Scanning speech (HP:0002168)2.33008944
90Megalencephaly (HP:0001355)2.32906476
91Increased CSF lactate (HP:0002490)2.29716134
92Increased neuronal autofluorescent lipopigment (HP:0002074)2.28962617
93Severe Myopia (HP:0011003)2.27624256
94Large eyes (HP:0001090)2.25934649
95Increased cerebral lipofuscin (HP:0011813)2.25444657
96Progressive macrocephaly (HP:0004481)2.25122896
97Tachypnea (HP:0002789)2.24883228
98Aplasia/Hypoplasia of the patella (HP:0006498)2.24505110
99Generalized myoclonic seizures (HP:0002123)2.23217204
100Muscular hypotonia of the trunk (HP:0008936)2.22480671
101Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22160362
102Genetic anticipation (HP:0003743)2.22045065
103Abnormal hair whorl (HP:0010721)2.21612024
104Sensory axonal neuropathy (HP:0003390)2.21473715
105Oligomenorrhea (HP:0000876)2.21390713
106Action tremor (HP:0002345)2.21324578
107Cortical dysplasia (HP:0002539)2.19651236
108Papilledema (HP:0001085)2.19515532
109Hypoglycemic seizures (HP:0002173)2.19268320
110Hypothermia (HP:0002045)2.17083753
111Patellar aplasia (HP:0006443)2.16620234
112Hyperglycinemia (HP:0002154)2.15927848
113Intention tremor (HP:0002080)2.14941181
114Abnormality of the renal medulla (HP:0100957)2.14289337
115Spastic tetraplegia (HP:0002510)2.13665298
116Amyotrophic lateral sclerosis (HP:0007354)2.13467545
117Hemiparesis (HP:0001269)2.12667489
118Hypoventilation (HP:0002791)2.11791643
119Wrist flexion contracture (HP:0001239)2.10639918
120Ketoacidosis (HP:0001993)2.08461829
121Abnormal number of incisors (HP:0011064)2.07715399
122Hepatocellular necrosis (HP:0001404)2.05109860
123Abnormality of pain sensation (HP:0010832)2.04593304
124Impaired pain sensation (HP:0007328)2.04593304
125Hyperthyroidism (HP:0000836)2.03557735
126Optic nerve coloboma (HP:0000588)2.03347779
127Sensorimotor neuropathy (HP:0007141)2.02868968
128Specific learning disability (HP:0001328)2.00706572
129Cortical visual impairment (HP:0100704)1.99544414
130Hemiplegia (HP:0002301)1.98813332
131Confusion (HP:0001289)1.98492499
132Peripheral hypomyelination (HP:0007182)1.97996872
133Atrophy/Degeneration involving motor neurons (HP:0007373)1.97788727
134Increased hepatocellular lipid droplets (HP:0006565)1.97313110
135Vaginal atresia (HP:0000148)1.97190328
136Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97114013
137Degeneration of the lateral corticospinal tracts (HP:0002314)1.97114013
138Nuclear cataract (HP:0100018)1.96930452
139Symptomatic seizures (HP:0011145)1.96031317
140Absent speech (HP:0001344)1.95784869
141Optic nerve hypoplasia (HP:0000609)1.95628456
142Diplopia (HP:0000651)1.95572057
143Abnormality of binocular vision (HP:0011514)1.95572057
144Delayed myelination (HP:0012448)1.94497527
145Cerebral hypomyelination (HP:0006808)1.94433869
146Impaired social interactions (HP:0000735)1.93783707
147Abnormal social behavior (HP:0012433)1.93783707
148Lower limb muscle weakness (HP:0007340)1.93106841
149Poor eye contact (HP:0000817)1.92689939
150Abnormality of the vocal cords (HP:0008777)1.92115340
151Lipid accumulation in hepatocytes (HP:0006561)1.90566160
152Genital tract atresia (HP:0001827)1.89926368
153Abnormality of the pons (HP:0007361)1.89078502
154Postural instability (HP:0002172)1.88594423
155Abnormality of calcium-phosphate metabolism (HP:0100530)1.88349543
156Congenital stationary night blindness (HP:0007642)1.88264779
157Athetosis (HP:0002305)1.87501498
158Bradykinesia (HP:0002067)1.86963629
159Tubulointerstitial nephritis (HP:0001970)1.86396868
160Pendular nystagmus (HP:0012043)1.86374517
161Occipital encephalocele (HP:0002085)1.84837552
162Abolished electroretinogram (ERG) (HP:0000550)1.84593034
163Ketosis (HP:0001946)1.84591684
164Abnormality of salivation (HP:0100755)1.83450618
165Partial agenesis of the corpus callosum (HP:0001338)1.81570718
166Sporadic (HP:0003745)1.80982877
167Rigidity (HP:0002063)1.80873378
168Late onset (HP:0003584)1.80431605
169Widely spaced teeth (HP:0000687)1.80230122
170Methylmalonic aciduria (HP:0012120)1.79747231
171Dysdiadochokinesis (HP:0002075)1.79545795
172Hypomagnesemia (HP:0002917)1.79463488
173Bile duct proliferation (HP:0001408)1.76887927
174Abnormal biliary tract physiology (HP:0012439)1.76887927
175Hepatic necrosis (HP:0002605)1.76676576
176Polymicrogyria (HP:0002126)1.76330126
177Cerebellar dysplasia (HP:0007033)1.76153115
178Sclerocornea (HP:0000647)1.75978493
179Hyperinsulinemic hypoglycemia (HP:0000825)1.75250413
180Optic disc pallor (HP:0000543)1.74252451
181Dyskinesia (HP:0100660)1.74116692
182Narrow forehead (HP:0000341)1.72568651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.17463761
2TRIM284.12038957
3NTRK33.40682042
4PTK63.29992530
5CASK3.06812957
6MAP4K22.96426774
7MAPKAPK52.87571720
8MAP3K42.83561992
9MINK12.73619934
10MAP2K42.62967308
11WNK32.57287583
12MARK12.49646246
13NTRK22.36325037
14NME12.22693257
15PAK22.18386810
16FES2.15524412
17MAP3K92.10695309
18EPHA42.09531957
19UHMK12.08958971
20MAP2K72.05450691
21TESK22.02996159
22SRPK12.00740296
23NEK11.98983469
24MAP3K121.94668671
25SIK31.91779553
26KSR21.91335222
27EPHA31.85187512
28NTRK11.83502010
29STK391.76978927
30PINK11.72194744
31ERBB31.63917629
32OXSR11.57593306
33NUAK11.54249445
34PAK61.49773457
35IRAK11.47984647
36FER1.46664264
37STK161.44053509
38WNK11.41416408
39DYRK31.41240556
40CDK51.40120977
41FRK1.39918134
42GRK11.37808601
43LATS21.36463786
44ALK1.34965116
45TESK11.32743797
46TSSK61.28582440
47PAK31.24780979
48RIPK41.23403079
49PHKG21.22013143
50PHKG11.22013143
51ADRBK21.18006869
52CAMK2B1.16289090
53CAMK2D1.15513083
54PDK31.15061068
55PDK41.15061068
56INSRR1.14040720
57PRKCG1.12031400
58CDK191.11767684
59LIMK11.10703168
60PKN21.10061365
61TNIK1.08901068
62KDR1.08180394
63CAMKK21.05217648
64CSNK1G30.95746860
65CAMK2G0.94044039
66LMTK20.93322101
67MAP3K60.92824615
68RPS6KA40.91524893
69ROCK20.88465370
70CSNK1G20.88213348
71BCKDK0.87724125
72CAMK2A0.87699213
73MAPK150.86815477
74RIPK10.84071694
75GRK50.83904297
76BCR0.81655091
77TAOK10.80739243
78CDK140.79257599
79BMPR1B0.78046848
80PRKCH0.77626098
81CDK150.77465721
82CDC42BPA0.76930890
83PDK20.76399683
84CDK180.75232610
85CSNK1A1L0.73406838
86AKT30.73162882
87CSNK1E0.73087613
88RET0.72765190
89PLK20.72483229
90CAMK1G0.72389485
91MAPK100.72141172
92PRKCI0.71727418
93PRKCE0.67104026
94DYRK1B0.66978375
95MAP3K10.65906129
96ERBB20.65300652
97PKN10.64206238
98CDK11A0.59593121
99MAPKAPK30.59137920
100PRKAA20.58947105
101IKBKE0.58865237
102MAP3K20.58813911
103DYRK1A0.54717424
104CLK10.54003928
105DAPK20.53854237
106MAP2K60.52715256
107TIE10.52101998
108CSNK1D0.52072726
109STK38L0.51492818
110PRKD20.51225937
111CSNK1A10.50087642
112RPS6KA50.49529546
113MAPK120.49237097
114CAMK10.48625995
115LYN0.48519963
116PLK10.47319524
117CAMK40.46295444
118RPS6KA30.46020358
119ADRBK10.43949013
120PDK10.42710388
121KSR10.42096148
122WNK40.40762584
123PRKCB0.40651416
124MAPK130.39868460
125CSNK1G10.39853280
126PDPK10.39092631
127JAK20.38530747
128EPHB10.38426754
129PLK30.37939038
130BUB10.37756643
131PRKCQ0.37566528
132PRKCZ0.37358855
133SIK20.37274409
134PIM20.35985122
135FYN0.35539068
136MAP3K50.34478023
137PRKACB0.33967739
138PRKACA0.33938344
139TYRO30.33377725
140SGK10.31751613
141DYRK20.31698055
142MAPK70.31640940
143PRKAA10.31632305
144PRKG10.31558855
145MAPK40.31102541
146MAP2K20.30294646
147SGK4940.30167484
148SGK2230.30167484
149VRK20.29794105
150ZAK0.29438730
151AURKA0.28451217
152MAPK90.28035038
153MARK30.27488947

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.54761839
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.44040951
3Nitrogen metabolism_Homo sapiens_hsa009103.25581247
4GABAergic synapse_Homo sapiens_hsa047273.19234349
5Synaptic vesicle cycle_Homo sapiens_hsa047213.09358867
6Proteasome_Homo sapiens_hsa030502.78505616
7Protein export_Homo sapiens_hsa030602.76617397
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72039198
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.70500484
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.61609768
11Morphine addiction_Homo sapiens_hsa050322.48698692
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.40560292
13Oxidative phosphorylation_Homo sapiens_hsa001902.19039351
14Caffeine metabolism_Homo sapiens_hsa002322.11508079
15Collecting duct acid secretion_Homo sapiens_hsa049661.94392883
16Steroid biosynthesis_Homo sapiens_hsa001001.84848357
17Circadian entrainment_Homo sapiens_hsa047131.80849578
18Glutamatergic synapse_Homo sapiens_hsa047241.78928295
19Cardiac muscle contraction_Homo sapiens_hsa042601.76731349
20Vitamin B6 metabolism_Homo sapiens_hsa007501.75698880
21Non-homologous end-joining_Homo sapiens_hsa034501.74512623
22Long-term potentiation_Homo sapiens_hsa047201.68652206
23Taste transduction_Homo sapiens_hsa047421.67990492
24Parkinsons disease_Homo sapiens_hsa050121.66638035
25Long-term depression_Homo sapiens_hsa047301.66571502
26Amphetamine addiction_Homo sapiens_hsa050311.65803044
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62243741
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62226275
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.59100401
30Vibrio cholerae infection_Homo sapiens_hsa051101.54038583
31Peroxisome_Homo sapiens_hsa041461.54025539
32Olfactory transduction_Homo sapiens_hsa047401.52286501
33Dopaminergic synapse_Homo sapiens_hsa047281.49084056
34Alzheimers disease_Homo sapiens_hsa050101.47705036
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47117533
36Regulation of autophagy_Homo sapiens_hsa041401.44252507
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41571398
38Cocaine addiction_Homo sapiens_hsa050301.41489938
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40433833
40Prion diseases_Homo sapiens_hsa050201.40053523
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36479753
42Ether lipid metabolism_Homo sapiens_hsa005651.34647311
43Serotonergic synapse_Homo sapiens_hsa047261.29698690
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29447746
45Cholinergic synapse_Homo sapiens_hsa047251.29098339
46Butanoate metabolism_Homo sapiens_hsa006501.28634484
47RNA polymerase_Homo sapiens_hsa030201.28356061
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19047353
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18447842
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17081186
51Insulin secretion_Homo sapiens_hsa049111.16437077
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15338339
53Selenocompound metabolism_Homo sapiens_hsa004501.14993608
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14048443
55Salivary secretion_Homo sapiens_hsa049701.13778892
56Renal cell carcinoma_Homo sapiens_hsa052111.11983942
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11731787
58Arginine biosynthesis_Homo sapiens_hsa002201.10217582
59Gastric acid secretion_Homo sapiens_hsa049711.10000868
60Huntingtons disease_Homo sapiens_hsa050161.08620913
61Renin secretion_Homo sapiens_hsa049241.08057505
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05720893
63Dorso-ventral axis formation_Homo sapiens_hsa043201.04975619
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01817101
65Axon guidance_Homo sapiens_hsa043601.01197440
66Gap junction_Homo sapiens_hsa045401.00945971
67Sulfur metabolism_Homo sapiens_hsa009200.99886814
68GnRH signaling pathway_Homo sapiens_hsa049120.99587425
69Fanconi anemia pathway_Homo sapiens_hsa034600.98729857
70ErbB signaling pathway_Homo sapiens_hsa040120.98521314
71Basal transcription factors_Homo sapiens_hsa030220.95814112
72Type II diabetes mellitus_Homo sapiens_hsa049300.94798229
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.94096748
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93889020
75Linoleic acid metabolism_Homo sapiens_hsa005910.92922088
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91753202
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91209091
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.90025059
79Estrogen signaling pathway_Homo sapiens_hsa049150.88387741
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86240413
81Oxytocin signaling pathway_Homo sapiens_hsa049210.83741462
82Bile secretion_Homo sapiens_hsa049760.80134446
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79664978
84Dilated cardiomyopathy_Homo sapiens_hsa054140.75401152
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73625577
86Oocyte meiosis_Homo sapiens_hsa041140.73043958
87ABC transporters_Homo sapiens_hsa020100.70381647
88Pyruvate metabolism_Homo sapiens_hsa006200.69613499
89Alcoholism_Homo sapiens_hsa050340.67342336
90Fatty acid elongation_Homo sapiens_hsa000620.66149666
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65310917
92Calcium signaling pathway_Homo sapiens_hsa040200.63417792
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61959312
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58866581
95Tryptophan metabolism_Homo sapiens_hsa003800.56858966
96Spliceosome_Homo sapiens_hsa030400.53335754
97Metabolic pathways_Homo sapiens_hsa011000.53097203
98Pancreatic secretion_Homo sapiens_hsa049720.52374642
99Retinol metabolism_Homo sapiens_hsa008300.52085891
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50328144
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50231946
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49411217
103Carbon metabolism_Homo sapiens_hsa012000.48033351
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.47877927
105Melanoma_Homo sapiens_hsa052180.47281913
106Type I diabetes mellitus_Homo sapiens_hsa049400.46096333
107cAMP signaling pathway_Homo sapiens_hsa040240.44947495
108Melanogenesis_Homo sapiens_hsa049160.44053362
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43411898
110Histidine metabolism_Homo sapiens_hsa003400.43155704
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42835590
112RNA degradation_Homo sapiens_hsa030180.42823188
113Arginine and proline metabolism_Homo sapiens_hsa003300.41109233
114beta-Alanine metabolism_Homo sapiens_hsa004100.40985851
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40340119
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.40104055
117Propanoate metabolism_Homo sapiens_hsa006400.38734651
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36799594
119Chemical carcinogenesis_Homo sapiens_hsa052040.36776604
120Fat digestion and absorption_Homo sapiens_hsa049750.36541403
121Biosynthesis of amino acids_Homo sapiens_hsa012300.36465303
122Rheumatoid arthritis_Homo sapiens_hsa053230.36434355
123Starch and sucrose metabolism_Homo sapiens_hsa005000.36254764
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35847320
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35843332
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34752671
127Choline metabolism in cancer_Homo sapiens_hsa052310.34002713
128Glioma_Homo sapiens_hsa052140.33407122
129Salmonella infection_Homo sapiens_hsa051320.33403978
130Phototransduction_Homo sapiens_hsa047440.32701220
131MAPK signaling pathway_Homo sapiens_hsa040100.32136438
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32124229
133Phagosome_Homo sapiens_hsa041450.31581423
134Ras signaling pathway_Homo sapiens_hsa040140.30615972
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30505536
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29544421
137Tyrosine metabolism_Homo sapiens_hsa003500.28957559
138Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27598671
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26714020
140Phenylalanine metabolism_Homo sapiens_hsa003600.26609122
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.26587799
142Cysteine and methionine metabolism_Homo sapiens_hsa002700.26202171
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.25265419
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23505496
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23084439
146Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.21638989

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