HCN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.31709598
2nucleobase catabolic process (GO:0046113)5.42751037
3vocalization behavior (GO:0071625)4.83666694
4neuron cell-cell adhesion (GO:0007158)4.79818618
5L-phenylalanine catabolic process (GO:0006559)4.32008966
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.32008966
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.24355546
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.23906178
9L-phenylalanine metabolic process (GO:0006558)4.15744749
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.15744749
11protein localization to synapse (GO:0035418)4.08252635
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.08010503
13synaptic vesicle maturation (GO:0016188)3.90534039
14proline transport (GO:0015824)3.89789515
15coenzyme catabolic process (GO:0009109)3.85605941
16cellular ketone body metabolic process (GO:0046950)3.83587696
17presynaptic membrane assembly (GO:0097105)3.81041018
18auditory behavior (GO:0031223)3.79330787
19cell migration in hindbrain (GO:0021535)3.70914085
20aromatic amino acid family catabolic process (GO:0009074)3.67902440
21layer formation in cerebral cortex (GO:0021819)3.66879215
22regulation of glutamate receptor signaling pathway (GO:1900449)3.64323069
23presynaptic membrane organization (GO:0097090)3.62369692
24neurofilament cytoskeleton organization (GO:0060052)3.61439017
25synaptic vesicle exocytosis (GO:0016079)3.56979361
26neurotransmitter secretion (GO:0007269)3.55125536
27gamma-aminobutyric acid transport (GO:0015812)3.52278895
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.51233537
29dendritic spine morphogenesis (GO:0060997)3.50978276
30glutamate secretion (GO:0014047)3.48536524
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.42723809
32neuron recognition (GO:0008038)3.36810426
33negative regulation of microtubule polymerization (GO:0031115)3.36225717
34adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.34686163
35central nervous system projection neuron axonogenesis (GO:0021952)3.31933050
36ketone body metabolic process (GO:1902224)3.29183644
37exploration behavior (GO:0035640)3.28620644
38alkaloid metabolic process (GO:0009820)3.27273880
39locomotory exploration behavior (GO:0035641)3.22934554
40neuronal ion channel clustering (GO:0045161)3.20025723
41regulation of synapse structural plasticity (GO:0051823)3.17152892
42bile acid and bile salt transport (GO:0015721)3.14681765
43kynurenine metabolic process (GO:0070189)3.14606248
44mechanosensory behavior (GO:0007638)3.12562326
45axon extension (GO:0048675)3.12224955
46behavioral response to cocaine (GO:0048148)3.09835955
47tryptophan catabolic process (GO:0006569)3.09475226
48indole-containing compound catabolic process (GO:0042436)3.09475226
49indolalkylamine catabolic process (GO:0046218)3.09475226
50neurotransmitter catabolic process (GO:0042135)3.09252713
51sulfur amino acid catabolic process (GO:0000098)3.08733650
52high-density lipoprotein particle remodeling (GO:0034375)3.07448926
53neurotransmitter transport (GO:0006836)3.06294595
54regulation of neurotransmitter levels (GO:0001505)3.05173148
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.02477613
56positive regulation of synapse maturation (GO:0090129)3.02201703
57regulation of synaptic vesicle exocytosis (GO:2000300)3.02194494
58postsynaptic membrane organization (GO:0001941)2.99964384
59aromatic amino acid family metabolic process (GO:0009072)2.99523863
60retinal ganglion cell axon guidance (GO:0031290)2.98866449
61negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.97769637
62bile acid biosynthetic process (GO:0006699)2.96782721
63regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95685515
64synaptic transmission, glutamatergic (GO:0035249)2.95441853
65response to histamine (GO:0034776)2.94852013
66phenol-containing compound catabolic process (GO:0019336)2.94194877
67urea metabolic process (GO:0019627)2.93402576
68urea cycle (GO:0000050)2.93402576
69cellular modified amino acid catabolic process (GO:0042219)2.92471394
70tyrosine metabolic process (GO:0006570)2.89821870
71mitochondrion transport along microtubule (GO:0047497)2.89532235
72establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.89532235
73positive regulation of amino acid transport (GO:0051957)2.87679505
74activation of protein kinase A activity (GO:0034199)2.86905508
75spinal cord development (GO:0021510)2.86473341
76response to auditory stimulus (GO:0010996)2.85945269
77glyoxylate metabolic process (GO:0046487)2.83658909
78ionotropic glutamate receptor signaling pathway (GO:0035235)2.82940543
79behavioral response to nicotine (GO:0035095)2.82703009
80neurotransmitter-gated ion channel clustering (GO:0072578)2.82595104
81prepulse inhibition (GO:0060134)2.81216219
82social behavior (GO:0035176)2.80621004
83intraspecies interaction between organisms (GO:0051703)2.80621004
84tryptophan metabolic process (GO:0006568)2.78125792
85regulation of respiratory system process (GO:0044065)2.77630311
86serine family amino acid catabolic process (GO:0009071)2.77246549
87flavonoid metabolic process (GO:0009812)2.77079957
88hippocampus development (GO:0021766)2.76365068
89regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.76218168
90cell-cell junction maintenance (GO:0045217)2.75458983
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.74825617
92synaptic transmission, cholinergic (GO:0007271)2.74401562
93ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.74362262
94regulation of vesicle fusion (GO:0031338)2.73984909
95glutamate metabolic process (GO:0006536)2.73673730
96drug catabolic process (GO:0042737)2.73391956
97dopamine biosynthetic process (GO:0042416)2.73383759
98synapse assembly (GO:0007416)2.73360848
99alpha-linolenic acid metabolic process (GO:0036109)2.72924922
100nitrogen cycle metabolic process (GO:0071941)2.72314339
101negative regulation of fibrinolysis (GO:0051918)2.71913837
102indolalkylamine metabolic process (GO:0006586)2.71790318
103regulation of axon guidance (GO:1902667)2.71582347
104neuronal action potential propagation (GO:0019227)2.71366039
105cysteine metabolic process (GO:0006534)2.70904284
106axonal fasciculation (GO:0007413)2.70701610
107cerebellar Purkinje cell differentiation (GO:0021702)2.70418149
108bile acid metabolic process (GO:0008206)2.69784525
109calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.69578127
110dendrite morphogenesis (GO:0048813)2.69178735
111establishment of mitochondrion localization (GO:0051654)2.68273657
112regulation of cholesterol esterification (GO:0010872)2.67538965
113negative regulation of axon extension (GO:0030517)2.67084942
114regulation of fibrinolysis (GO:0051917)2.66603932
115regulation of synaptic vesicle transport (GO:1902803)2.65437863
116synapse organization (GO:0050808)2.65251144
117positive regulation of synaptic transmission, GABAergic (GO:0032230)2.64937743
118adult walking behavior (GO:0007628)2.64731333
119alanine transport (GO:0032328)2.64571588
120membrane depolarization during action potential (GO:0086010)2.64442380
121transmission of nerve impulse (GO:0019226)2.64433620
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.64001238
123cerebellum development (GO:0021549)2.62723046
124sympathetic nervous system development (GO:0048485)2.62417596
125negative regulation of sterol transport (GO:0032372)2.62164762
126negative regulation of cholesterol transport (GO:0032375)2.62164762
127negative regulation of axonogenesis (GO:0050771)2.61981837
128neuron-neuron synaptic transmission (GO:0007270)2.61940822
129nonmotile primary cilium assembly (GO:0035058)2.61857443
130dopamine transport (GO:0015872)2.61603820
131catecholamine transport (GO:0051937)2.61596480
132regulation of long-term neuronal synaptic plasticity (GO:0048169)2.61428153
133neuromuscular process controlling posture (GO:0050884)2.61377709
134positive regulation of synapse assembly (GO:0051965)2.60124235
135glutamate receptor signaling pathway (GO:0007215)2.60099524
136mating behavior (GO:0007617)2.59953730
137regulation of neuronal synaptic plasticity (GO:0048168)2.59948440
138membrane hyperpolarization (GO:0060081)2.55894630
139response to dietary excess (GO:0002021)2.54112022
140neuron projection extension (GO:1990138)2.51968040
141central nervous system neuron axonogenesis (GO:0021955)2.50655849
142neuromuscular synaptic transmission (GO:0007274)2.50207324
143synaptic vesicle docking involved in exocytosis (GO:0016081)2.49925851
144cell junction maintenance (GO:0034331)2.48644368
145startle response (GO:0001964)2.46878547
146dopamine receptor signaling pathway (GO:0007212)2.46719909
147organelle transport along microtubule (GO:0072384)2.46321988
148regulation of feeding behavior (GO:0060259)2.46309272
149short-term memory (GO:0007614)2.44800647
150glycosphingolipid biosynthetic process (GO:0006688)2.43519343
151regulation of respiratory gaseous exchange (GO:0043576)2.41764667
152positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.41349732
153negative regulation of axon guidance (GO:1902668)2.40782963
154substrate-independent telencephalic tangential migration (GO:0021826)2.40780063
155substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.40780063
156neuron migration (GO:0001764)2.40189290
157head development (GO:0060322)2.38713408

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.82259680
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.33086281
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.26902906
4REST_21632747_ChIP-Seq_MESCs_Mouse2.94566100
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.77766705
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77065460
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67557964
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.63668774
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53585886
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.46651821
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43162278
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42114574
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42114574
14* REST_18959480_ChIP-ChIP_MESCs_Mouse2.37745273
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.36110148
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35361261
17GBX2_23144817_ChIP-Seq_PC3_Human2.34974956
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30010642
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.26992895
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.26364859
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22047828
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.18665408
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.17765733
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17727539
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16761071
26ERG_21242973_ChIP-ChIP_JURKAT_Human2.10790308
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.06645479
28TAF15_26573619_Chip-Seq_HEK293_Human1.90308928
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.85860870
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85560143
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84625278
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.82083753
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82011221
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76323495
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.74552286
36IGF1R_20145208_ChIP-Seq_DFB_Human1.72083567
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69882587
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65819204
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60631453
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.60035774
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56960393
42* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.56417943
43DROSHA_22980978_ChIP-Seq_HELA_Human1.50344493
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.49977090
45RNF2_27304074_Chip-Seq_NSC_Mouse1.46797487
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45178908
47RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41863863
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38079970
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.37684456
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.37173878
51AR_21572438_ChIP-Seq_LNCaP_Human1.36274364
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28998954
53ZNF274_21170338_ChIP-Seq_K562_Hela1.27026680
54RING1B_27294783_Chip-Seq_NPCs_Mouse1.24427912
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24282418
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18962711
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18564470
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17846004
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17433650
60VDR_22108803_ChIP-Seq_LS180_Human1.16775163
61CTCF_27219007_Chip-Seq_Bcells_Human1.14236044
62CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.11582946
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10854269
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.10057483
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07223222
66P300_19829295_ChIP-Seq_ESCs_Human1.06838178
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06483571
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06038174
69SMAD4_21799915_ChIP-Seq_A2780_Human1.05289002
70RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04587485
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03090216
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.02944397
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02880072
74PIAS1_25552417_ChIP-Seq_VCAP_Human0.97822345
75KDM2B_26808549_Chip-Seq_K562_Human0.97184813
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96375158
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94669846
78AR_19668381_ChIP-Seq_PC3_Human0.91928926
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91440509
80STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91311629
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90686999
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90686999
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90483756
84REST_19997604_ChIP-ChIP_NEURONS_Mouse0.90462044
85* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88048651
86SMAD3_21741376_ChIP-Seq_EPCs_Human0.87983969
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87364353
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86477726
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86474669
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86318826
91NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86011453
92JUN_21703547_ChIP-Seq_K562_Human0.85867081
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85535968
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85014240
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.84551577
96IRF1_19129219_ChIP-ChIP_H3396_Human0.84529364
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84148540
98AR_25329375_ChIP-Seq_VCAP_Human0.84143043
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83781063
100POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83534033
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83180662
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82115259
103CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80282528
104TP63_19390658_ChIP-ChIP_HaCaT_Human0.80266563
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.80140769
106HTT_18923047_ChIP-ChIP_STHdh_Human0.80101581
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.79950669
108SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79354971
109RUNX2_22187159_ChIP-Seq_PCA_Human0.78706676
110SOX3_22085726_ChIP-Seq_NPCs_Mouse0.78636119
111YY1_21170310_ChIP-Seq_MESCs_Mouse0.78531656
112AHR_22903824_ChIP-Seq_MCF-7_Human0.78390919
113ETV2_25802403_ChIP-Seq_MESCs_Mouse0.77760761
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.77716986
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77638286
116ZFP281_27345836_Chip-Seq_ESCs_Mouse0.77439582
117SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.76999205
118STAT3_23295773_ChIP-Seq_U87_Human0.76800547
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.76765882
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76226668
121ELK4_26923725_Chip-Seq_MESODERM_Mouse0.75980841
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.75552154
123SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74929395
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.74741893
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.74370250
126SOX9_26525672_Chip-Seq_HEART_Mouse0.73576774
127* ERA_21632823_ChIP-Seq_H3396_Human0.73306690
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.73077079
129E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.72377075
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.71392258
131POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.71281877
132* TET1_21490601_ChIP-Seq_MESCs_Mouse0.70909737

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.41537104
2MP0005360_urolithiasis3.68140016
3MP0004859_abnormal_synaptic_plasticity3.32797178
4MP0003880_abnormal_central_pattern3.32389570
5MP0006276_abnormal_autonomic_nervous3.17467221
6MP0005085_abnormal_gallbladder_physiolo3.03509285
7MP0004270_analgesia2.85722852
8MP0003635_abnormal_synaptic_transmissio2.80839715
9MP0008875_abnormal_xenobiotic_pharmacok2.73097082
10MP0005423_abnormal_somatic_nervous2.70137129
11MP0005365_abnormal_bile_salt2.67589639
12MP0002822_catalepsy2.51049389
13MP0001968_abnormal_touch/_nociception2.43014833
14MP0009745_abnormal_behavioral_response2.39488075
15MP0002063_abnormal_learning/memory/cond2.32746857
16MP0002734_abnormal_mechanical_nocicepti2.29543042
17MP0002572_abnormal_emotion/affect_behav2.26543307
18MP0001188_hyperpigmentation2.23281397
19MP0003121_genomic_imprinting2.15330413
20MP0002733_abnormal_thermal_nociception2.13726187
21MP0003787_abnormal_imprinting2.13591980
22MP0003122_maternal_imprinting2.12306605
23MP0002064_seizures2.11505570
24MP0009046_muscle_twitch2.06628874
25MP0005645_abnormal_hypothalamus_physiol1.99928811
26MP0001440_abnormal_grooming_behavior1.98100690
27MP0003123_paternal_imprinting1.97184944
28MP0001486_abnormal_startle_reflex1.96506146
29MP0001501_abnormal_sleep_pattern1.96190298
30MP0001529_abnormal_vocalization1.94942530
31MP0000778_abnormal_nervous_system1.88724030
32MP0002735_abnormal_chemical_nociception1.82655792
33MP0002736_abnormal_nociception_after1.80200659
34MP0002272_abnormal_nervous_system1.76645532
35MP0002184_abnormal_innervation1.74834534
36MP0004133_heterotaxia1.69067080
37MP0003329_amyloid_beta_deposits1.67684785
38MP0002557_abnormal_social/conspecific_i1.65439064
39MP0001970_abnormal_pain_threshold1.63412622
40MP0001905_abnormal_dopamine_level1.63205325
41MP0010329_abnormal_lipoprotein_level1.58808493
42MP0005386_behavior/neurological_phenoty1.57647493
43MP0004924_abnormal_behavior1.57647493
44MP0005083_abnormal_biliary_tract1.57152374
45MP0003252_abnormal_bile_duct1.54876296
46MP0002909_abnormal_adrenal_gland1.54736781
47MP0002067_abnormal_sensory_capabilities1.53384249
48MP0004858_abnormal_nervous_system1.52654647
49MP0003868_abnormal_feces_composition1.41930872
50MP0008872_abnormal_physiological_respon1.40561832
51MP0003011_delayed_dark_adaptation1.39311916
52MP0005499_abnormal_olfactory_system1.39133288
53MP0005394_taste/olfaction_phenotype1.39133288
54MP0004142_abnormal_muscle_tone1.38758831
55MP0000566_synostosis1.36909907
56MP0000955_abnormal_spinal_cord1.31060030
57MP0002653_abnormal_ependyma_morphology1.27612103
58MP0004742_abnormal_vestibular_system1.27518121
59MP0004811_abnormal_neuron_physiology1.24865600
60MP0003890_abnormal_embryonic-extraembry1.23895554
61MP0004147_increased_porphyrin_level1.23336330
62MP0003861_abnormal_nervous_system1.16749078
63MP0002882_abnormal_neuron_morphology1.16305347
64MP0008995_early_reproductive_senescence1.15187153
65MP0005535_abnormal_body_temperature1.14005868
66MP0002066_abnormal_motor_capabilities/c1.13459130
67MP0002638_abnormal_pupillary_reflex1.11901231
68MP0001984_abnormal_olfaction1.09679985
69MP0003283_abnormal_digestive_organ1.09324116
70MP0005332_abnormal_amino_acid1.06703692
71MP0001502_abnormal_circadian_rhythm1.05015438
72MP0006035_abnormal_mitochondrial_morpho1.04673299
73MP0002876_abnormal_thyroid_physiology1.03467432
74MP0000604_amyloidosis1.03220829
75MP0002102_abnormal_ear_morphology1.02396164
76MP0003938_abnormal_ear_development1.01081796
77MP0002751_abnormal_autonomic_nervous1.00847839
78MP0005646_abnormal_pituitary_gland1.00813727
79MP0003119_abnormal_digestive_system1.00795172
80MP0001986_abnormal_taste_sensitivity1.00644241
81MP0002069_abnormal_eating/drinking_beha0.99666562
82MP0001666_abnormal_nutrient_absorption0.99630817
83MP0004019_abnormal_vitamin_homeostasis0.98832747
84MP0005551_abnormal_eye_electrophysiolog0.97403633
85MP0006292_abnormal_olfactory_placode0.96689117
86MP0005379_endocrine/exocrine_gland_phen0.95433120
87MP0002152_abnormal_brain_morphology0.92965663
88MP0000631_abnormal_neuroendocrine_gland0.92650603
89MP0000026_abnormal_inner_ear0.90613442
90MP0003942_abnormal_urinary_system0.89917092
91MP0002118_abnormal_lipid_homeostasis0.89308668
92MP0008789_abnormal_olfactory_epithelium0.88616936
93MP0002837_dystrophic_cardiac_calcinosis0.88457345
94MP0004145_abnormal_muscle_electrophysio0.86233602
95MP0002229_neurodegeneration0.86106237
96MP0003879_abnormal_hair_cell0.85735157
97MP0009780_abnormal_chondrocyte_physiolo0.83875720
98MP0002249_abnormal_larynx_morphology0.83844840
99MP0008961_abnormal_basal_metabolism0.82747027
100MP0002752_abnormal_somatic_nervous0.82728203
101MP0000049_abnormal_middle_ear0.82069278
102MP0008874_decreased_physiological_sensi0.78578017
103MP0005195_abnormal_posterior_eye0.78423856
104MP0008569_lethality_at_weaning0.77803379
105MP0002928_abnormal_bile_duct0.77293128
106MP0005448_abnormal_energy_balance0.76789338
107MP0002081_perinatal_lethality0.76785900
108MP0002163_abnormal_gland_morphology0.76538482
109MP0004885_abnormal_endolymph0.76345887
110MP0001963_abnormal_hearing_physiology0.73199201
111MP0002078_abnormal_glucose_homeostasis0.73031485
112MP0003656_abnormal_erythrocyte_physiolo0.72662988
113MP0000538_abnormal_urinary_bladder0.71483522
114MP0003315_abnormal_perineum_morphology0.71205939
115MP0001348_abnormal_lacrimal_gland0.70165794
116MP0000609_abnormal_liver_physiology0.68451455
117MP0002090_abnormal_vision0.67888838
118MP0006072_abnormal_retinal_apoptosis0.67783132
119MP0010386_abnormal_urinary_bladder0.67747713
120MP0002254_reproductive_system_inflammat0.67487869
121MP0003953_abnormal_hormone_level0.67304370
122MP0009379_abnormal_foot_pigmentation0.66908275
123MP0009840_abnormal_foam_cell0.66580416
124MP0005253_abnormal_eye_physiology0.66537453
125MP0008877_abnormal_DNA_methylation0.65680034
126MP0003195_calcinosis0.65078223
127MP0010770_preweaning_lethality0.64641111
128MP0002082_postnatal_lethality0.64641111
129MP0001943_abnormal_respiration0.64358110
130MP0005584_abnormal_enzyme/coenzyme_acti0.64308313
131MP0003385_abnormal_body_wall0.63443696
132MP0001299_abnormal_eye_distance/0.62869437
133MP0002234_abnormal_pharynx_morphology0.62698183
134MP0004130_abnormal_muscle_cell0.62426034
135MP0005187_abnormal_penis_morphology0.62059286
136MP0003631_nervous_system_phenotype0.61004249
137MP0001324_abnormal_eye_pigmentation0.60691198

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.40598829
2Myokymia (HP:0002411)4.22559791
3Limb dystonia (HP:0002451)3.91066701
4Visual hallucinations (HP:0002367)3.89192200
5Focal motor seizures (HP:0011153)3.88285851
6Deep venous thrombosis (HP:0002625)3.71660164
7Hypobetalipoproteinemia (HP:0003563)3.68769990
8Focal seizures (HP:0007359)3.67448948
9Cortical dysplasia (HP:0002539)3.64500984
10Hyperventilation (HP:0002883)3.39979601
11Gait imbalance (HP:0002141)3.30372534
12Abnormality of the lower motor neuron (HP:0002366)3.28611776
13Abnormality of monocarboxylic acid metabolism (HP:0010996)3.18404816
14Abnormality of the corticospinal tract (HP:0002492)3.17608948
15Hypochromic microcytic anemia (HP:0004840)3.16321692
16Prolonged partial thromboplastin time (HP:0003645)3.08974018
17Epileptic encephalopathy (HP:0200134)3.05913521
18Intrahepatic cholestasis (HP:0001406)3.03088010
19Febrile seizures (HP:0002373)3.02319158
20Amblyopia (HP:0000646)3.00290285
21Generalized tonic-clonic seizures (HP:0002069)2.99423256
22Xanthomatosis (HP:0000991)2.97817745
23Hypoplasia of the brainstem (HP:0002365)2.91113920
24Aplasia/Hypoplasia of the brainstem (HP:0007362)2.91113920
25Hyperlipoproteinemia (HP:0010980)2.89968837
26Hyperglycinemia (HP:0002154)2.88199462
27Absence seizures (HP:0002121)2.83760523
28Amyotrophic lateral sclerosis (HP:0007354)2.83692078
29Morphological abnormality of the pyramidal tract (HP:0002062)2.76135155
30Atonic seizures (HP:0010819)2.74925902
31Dialeptic seizures (HP:0011146)2.71901469
32EEG with generalized epileptiform discharges (HP:0011198)2.71460222
33Failure to thrive in infancy (HP:0001531)2.71283981
34Excessive salivation (HP:0003781)2.69834767
35Drooling (HP:0002307)2.69834767
36Hypsarrhythmia (HP:0002521)2.68467270
37Cerebral inclusion bodies (HP:0100314)2.67382074
38Status epilepticus (HP:0002133)2.65117405
39Supranuclear gaze palsy (HP:0000605)2.64092532
40Epileptiform EEG discharges (HP:0011182)2.63685692
41Abnormality of the labia minora (HP:0012880)2.61958009
42Pachygyria (HP:0001302)2.59844161
43Lissencephaly (HP:0001339)2.58809299
44Agitation (HP:0000713)2.56797752
45Epidermoid cyst (HP:0200040)2.56736997
46Poor suck (HP:0002033)2.56036623
47Polyphagia (HP:0002591)2.55710632
48Retinal dysplasia (HP:0007973)2.54320772
49Congenital primary aphakia (HP:0007707)2.50715555
50Mutism (HP:0002300)2.49062674
51Pheochromocytoma (HP:0002666)2.49049083
52Shawl scrotum (HP:0000049)2.48363727
53Sleep apnea (HP:0010535)2.46085849
54Progressive cerebellar ataxia (HP:0002073)2.44682278
55Impaired social interactions (HP:0000735)2.40946559
56Abnormal social behavior (HP:0012433)2.40946559
57Nephrogenic diabetes insipidus (HP:0009806)2.40444443
58Hepatoblastoma (HP:0002884)2.39739501
59Neurofibrillary tangles (HP:0002185)2.38419465
60Ketosis (HP:0001946)2.36319437
61Medial flaring of the eyebrow (HP:0010747)2.34260050
62Hyperglycinuria (HP:0003108)2.32211112
63Poor eye contact (HP:0000817)2.25545973
64Anxiety (HP:0000739)2.24222308
65Hemiparesis (HP:0001269)2.23401604
66Torticollis (HP:0000473)2.21076726
67Cholecystitis (HP:0001082)2.20900434
68Abnormal gallbladder physiology (HP:0012438)2.20900434
69Neuroendocrine neoplasm (HP:0100634)2.20390584
70Conjugated hyperbilirubinemia (HP:0002908)2.19173951
71Hypolipoproteinemia (HP:0010981)2.15328221
72Poor coordination (HP:0002370)2.14233022
73Complement deficiency (HP:0004431)2.13284506
74Irritability (HP:0000737)2.12513553
75Fetal akinesia sequence (HP:0001989)2.12092100
76Generalized hypotonia (HP:0001290)2.09425493
77Gout (HP:0001997)2.09215736
78Skin nodule (HP:0200036)2.08835207
79Focal dystonia (HP:0004373)2.08666070
80Abnormality of glycine metabolism (HP:0010895)2.06668181
81Abnormality of serine family amino acid metabolism (HP:0010894)2.06668181
82Restlessness (HP:0000711)2.05799359
83Ketoacidosis (HP:0001993)2.04584416
84Craniofacial dystonia (HP:0012179)2.03699308
85Nephronophthisis (HP:0000090)2.03543690
86Generalized myoclonic seizures (HP:0002123)2.03390970
87Specific learning disability (HP:0001328)2.03164666
88Esotropia (HP:0000565)2.02528004
89Broad-based gait (HP:0002136)2.02195252
90High anterior hairline (HP:0009890)2.01913009
91Urinary urgency (HP:0000012)2.01767763
92Genital tract atresia (HP:0001827)1.99233974
93Polymicrogyria (HP:0002126)1.99104481
94Hyperphosphaturia (HP:0003109)1.98391619
95Vaginal atresia (HP:0000148)1.97913599
96Depression (HP:0000716)1.97881900
97Spastic gait (HP:0002064)1.96913557
98Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95777450
99Hypoplasia of the corpus callosum (HP:0002079)1.95023464
100Abnormality of glutamine family amino acid metabolism (HP:0010902)1.93425678
101Papilledema (HP:0001085)1.93368837
102Oligodactyly (hands) (HP:0001180)1.92324710
103Neonatal onset (HP:0003623)1.92004194
104Tetraplegia (HP:0002445)1.90648883
105Cerebral edema (HP:0002181)1.90542512
106Urinary bladder sphincter dysfunction (HP:0002839)1.90330241
107Ankle clonus (HP:0011448)1.89377313
108Progressive inability to walk (HP:0002505)1.87608434
109Exotropia (HP:0000577)1.87559146
110Abnormal eating behavior (HP:0100738)1.86900631
111Acute encephalopathy (HP:0006846)1.86245684
112Inability to walk (HP:0002540)1.85291844
113Absent speech (HP:0001344)1.84929967
114Renal cortical cysts (HP:0000803)1.84479501
115Protruding tongue (HP:0010808)1.84243111
116Delusions (HP:0000746)1.83685231
117Hyperammonemia (HP:0001987)1.83062459
118Muscular hypotonia of the trunk (HP:0008936)1.83018833
119Reticulocytosis (HP:0001923)1.81430362
120Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80957279
121Akinesia (HP:0002304)1.80942790
122Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80726878
123Molar tooth sign on MRI (HP:0002419)1.80681901
124Abnormality of midbrain morphology (HP:0002418)1.80681901
125Abnormal hair whorl (HP:0010721)1.80043926
126Tubulointerstitial nephritis (HP:0001970)1.78900421
127Hyperbilirubinemia (HP:0002904)1.77901954
128Impaired vibration sensation in the lower limbs (HP:0002166)1.77852014
129Abnormal pupillary function (HP:0007686)1.77835668
130Hypothermia (HP:0002045)1.77443594
131Hyperinsulinemic hypoglycemia (HP:0000825)1.77354999
132Spastic tetraplegia (HP:0002510)1.75346725
133Hyperthyroidism (HP:0000836)1.75201199
134Delayed myelination (HP:0012448)1.74322453
135Intellectual disability, severe (HP:0010864)1.72846901
136Abnormality of the renal medulla (HP:0100957)1.71591456
137Narrow forehead (HP:0000341)1.63244755
138Degeneration of the lateral corticospinal tracts (HP:0002314)1.62861210
139Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.62861210
140Patellar aplasia (HP:0006443)1.62858662
141Genetic anticipation (HP:0003743)1.60052713
142Long foot (HP:0001833)1.58926970
143Abnormality of the heme biosynthetic pathway (HP:0010472)1.57413379
144Labial hypoplasia (HP:0000066)1.56126291
145Action tremor (HP:0002345)1.55528014
146Optic nerve coloboma (HP:0000588)1.54143426
147Thyroid-stimulating hormone excess (HP:0002925)1.53594597
148Aplasia/Hypoplasia of the patella (HP:0006498)1.51687873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.31671377
2MAP3K93.61898000
3NTRK33.27794892
4TAOK33.03768523
5GRK52.94070018
6CASK2.77824244
7NTRK22.72385085
8PNCK2.65831002
9MAP3K42.60412578
10MAP2K42.37212466
11NTRK12.30234530
12MINK12.24502730
13MAP2K72.19510103
14MAPK132.04435276
15GRK61.98487122
16DYRK21.94774533
17DAPK21.86456350
18SIK21.80299918
19UHMK11.74592763
20EPHA41.73813571
21MAP4K21.64482498
22MAP3K61.57487030
23MAP3K121.56138472
24PAK61.48510293
25LATS21.46875246
26PHKG11.43839717
27PHKG21.43839717
28TNIK1.30266442
29DYRK31.29562699
30DYRK1B1.29006772
31TRIM281.27437171
32CSNK1G21.24285918
33ARAF1.22503264
34CDK51.22057812
35GRK71.17764171
36EPHB21.17509332
37KSR21.16432040
38PRKCG1.14516310
39KSR11.12851055
40WNK31.09860270
41CSNK1G31.05144283
42TLK11.02957878
43WNK41.00900939
44ADRBK20.99867970
45DYRK1A0.98529083
46MARK20.96562426
47PAK30.95582453
48CAMK2A0.94364445
49TAOK10.93365343
50EPHA30.89801922
51DAPK10.88146511
52PKN10.86866600
53ADRBK10.85061167
54PINK10.84514047
55PRKCZ0.82166477
56CDK140.78264402
57CDK150.78135670
58CDK180.77492466
59STK110.74369605
60MAPK120.73777531
61NME10.73750414
62AKT30.72435049
63PLK20.70478217
64SIK10.69944714
65CDK11A0.69356607
66MAP2K60.68233981
67TYRO30.67823355
68PRKD30.66885761
69SGK20.64933689
70CAMK2B0.64018002
71CSNK1G10.62447807
72MAPK40.62015584
73GRK10.60158487
74MAPK150.59402734
75SRPK10.59380653
76CAMKK10.58713013
77RET0.58150674
78INSRR0.57392992
79NEK20.56645130
80MAP3K20.53710754
81SGK10.53370996
82CAMK1G0.52122726
83ERBB40.51911913
84CAMK2G0.51425829
85CDK190.51317865
86LMTK20.50356723
87CAMK40.49511305
88RPS6KA20.47645728
89CSNK1E0.46361877
90PRKCE0.44811056
91PRKACG0.44787351
92MATK0.44585743
93RIPK40.44153344
94RPS6KA40.43792142
95CSNK1A10.43516459
96ERBB20.42796509
97ICK0.42569246
98GSK3B0.42391796
99ABL20.40790380
100MAPK80.40777579
101CSNK1D0.40603517
102PRKACA0.39895675
103PRKAA10.39677971
104RPS6KA30.39673046
105FGFR20.39177059
106CDC70.38582518
107ERBB30.36671502
108STK380.36092828
109BCR0.35972411
110FES0.35596030
111CDK10.35197259
112CAMK10.35176866
113CSNK1A1L0.34745195
114PRKDC0.34715680
115MAP2K10.33968456
116MAPKAPK50.33222941
117GSK3A0.33112449
118PRKACB0.32605086
119PRKG10.32186645
120SGK2230.32157697
121SGK4940.32157697
122PRKCI0.32143853
123MAPK90.32096485
124MAP3K100.31928575
125PKN20.31785462
126CDK20.31228045
127MAPK140.30837608
128PTK20.30359080
129SIK30.30274469
130RPS6KB10.30107096
131BMPR1B0.29909177
132SGK30.27701958

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.90928860
2Nicotine addiction_Homo sapiens_hsa050332.85975990
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.58101158
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43204561
5Butanoate metabolism_Homo sapiens_hsa006502.32602622
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.22185541
7Arginine biosynthesis_Homo sapiens_hsa002202.16796061
8Synaptic vesicle cycle_Homo sapiens_hsa047212.14750897
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.09399961
10Tryptophan metabolism_Homo sapiens_hsa003802.07287205
11GABAergic synapse_Homo sapiens_hsa047271.94752353
12Nitrogen metabolism_Homo sapiens_hsa009101.89945218
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70017230
14Bile secretion_Homo sapiens_hsa049761.67301814
15Oxidative phosphorylation_Homo sapiens_hsa001901.56142008
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53597503
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53502995
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46832995
19Glutamatergic synapse_Homo sapiens_hsa047241.45386366
20Cocaine addiction_Homo sapiens_hsa050301.44934995
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.39860334
22Complement and coagulation cascades_Homo sapiens_hsa046101.36956899
23Amphetamine addiction_Homo sapiens_hsa050311.36404821
24Parkinsons disease_Homo sapiens_hsa050121.36001784
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35605799
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34869455
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.34546724
28Dopaminergic synapse_Homo sapiens_hsa047281.34361653
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32518063
30Taste transduction_Homo sapiens_hsa047421.30953416
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.29317704
32Tyrosine metabolism_Homo sapiens_hsa003501.28666582
33Phenylalanine metabolism_Homo sapiens_hsa003601.28320111
34Serotonergic synapse_Homo sapiens_hsa047261.27770150
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25085005
36Insulin secretion_Homo sapiens_hsa049111.24726687
37Chemical carcinogenesis_Homo sapiens_hsa052041.24390936
38Morphine addiction_Homo sapiens_hsa050321.24330689
39Vitamin B6 metabolism_Homo sapiens_hsa007501.24101960
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23721701
41Circadian entrainment_Homo sapiens_hsa047131.20300396
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16747528
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11622138
44Alzheimers disease_Homo sapiens_hsa050101.09232009
45PPAR signaling pathway_Homo sapiens_hsa033201.08152537
46Histidine metabolism_Homo sapiens_hsa003401.06769132
47Sulfur metabolism_Homo sapiens_hsa009201.06148872
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05160522
49Long-term potentiation_Homo sapiens_hsa047201.03763030
50Olfactory transduction_Homo sapiens_hsa047401.03502452
51Cholinergic synapse_Homo sapiens_hsa047251.02090154
52Fat digestion and absorption_Homo sapiens_hsa049751.00308040
53Steroid biosynthesis_Homo sapiens_hsa001000.99228179
54Cardiac muscle contraction_Homo sapiens_hsa042600.97158137
55Fatty acid degradation_Homo sapiens_hsa000710.96254762
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.94197022
57Pyruvate metabolism_Homo sapiens_hsa006200.93230612
58Retinol metabolism_Homo sapiens_hsa008300.91292073
59Salivary secretion_Homo sapiens_hsa049700.91168836
60Peroxisome_Homo sapiens_hsa041460.90642107
61Long-term depression_Homo sapiens_hsa047300.90320125
62Fatty acid metabolism_Homo sapiens_hsa012120.87338516
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86949604
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85447137
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83653025
66Axon guidance_Homo sapiens_hsa043600.79855518
67Collecting duct acid secretion_Homo sapiens_hsa049660.79783172
68Huntingtons disease_Homo sapiens_hsa050160.78784819
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77918877
70Gap junction_Homo sapiens_hsa045400.77809783
71Starch and sucrose metabolism_Homo sapiens_hsa005000.77732815
72Vibrio cholerae infection_Homo sapiens_hsa051100.77625048
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74416389
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73281321
75Biosynthesis of amino acids_Homo sapiens_hsa012300.72295322
76Renin secretion_Homo sapiens_hsa049240.72185041
77AMPK signaling pathway_Homo sapiens_hsa041520.71500674
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71046463
79Propanoate metabolism_Homo sapiens_hsa006400.70194039
80Alcoholism_Homo sapiens_hsa050340.68478014
81Type II diabetes mellitus_Homo sapiens_hsa049300.67927719
82Prion diseases_Homo sapiens_hsa050200.67606724
83Sulfur relay system_Homo sapiens_hsa041220.66405062
84beta-Alanine metabolism_Homo sapiens_hsa004100.65904412
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65595097
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63933900
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63901589
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61261402
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60858893
90Linoleic acid metabolism_Homo sapiens_hsa005910.59793047
91ABC transporters_Homo sapiens_hsa020100.59143417
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57693368
93GnRH signaling pathway_Homo sapiens_hsa049120.57030391
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56466025
95Fatty acid biosynthesis_Homo sapiens_hsa000610.55781183
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55639943
97Arginine and proline metabolism_Homo sapiens_hsa003300.55089312
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54449326
99Fatty acid elongation_Homo sapiens_hsa000620.53174426
100Protein export_Homo sapiens_hsa030600.52996471
101Calcium signaling pathway_Homo sapiens_hsa040200.51601227
102Oxytocin signaling pathway_Homo sapiens_hsa049210.51442970
103Gastric acid secretion_Homo sapiens_hsa049710.50945517
104Estrogen signaling pathway_Homo sapiens_hsa049150.50644857
105Hedgehog signaling pathway_Homo sapiens_hsa043400.48566721
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.48098646
107Ether lipid metabolism_Homo sapiens_hsa005650.47333586
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47212991
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.46600324
110Basal cell carcinoma_Homo sapiens_hsa052170.44780623
111Glycerolipid metabolism_Homo sapiens_hsa005610.44567071
112Phototransduction_Homo sapiens_hsa047440.43734334
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.43007062
114Melanogenesis_Homo sapiens_hsa049160.42560596
115Regulation of autophagy_Homo sapiens_hsa041400.42217974
116mRNA surveillance pathway_Homo sapiens_hsa030150.41104096
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40654972
118Basal transcription factors_Homo sapiens_hsa030220.40514617
119Hippo signaling pathway_Homo sapiens_hsa043900.39444067
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39232790
121cAMP signaling pathway_Homo sapiens_hsa040240.39210522
122ErbB signaling pathway_Homo sapiens_hsa040120.38929535
123Selenocompound metabolism_Homo sapiens_hsa004500.37521486
124Fructose and mannose metabolism_Homo sapiens_hsa000510.37502256
125Glucagon signaling pathway_Homo sapiens_hsa049220.36759331

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