HCG4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)4.30598680
2regulation of T-helper 1 cell differentiation (GO:0045625)4.27702463
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.25207119
4regulation of vitamin D biosynthetic process (GO:0060556)4.22348945
5immunoglobulin mediated immune response (GO:0016064)4.12702126
6type I interferon signaling pathway (GO:0060337)4.11276355
7cellular response to type I interferon (GO:0071357)4.11276355
8response to type I interferon (GO:0034340)4.08942417
9receptor guanylyl cyclase signaling pathway (GO:0007168)4.00296830
10positive regulation of gamma-delta T cell activation (GO:0046645)3.93271842
11NIK/NF-kappaB signaling (GO:0038061)3.91934602
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.83866589
13positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.82510955
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.77617584
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.71500456
16antigen processing and presentation of endogenous antigen (GO:0019883)3.68178063
17negative regulation of interleukin-12 production (GO:0032695)3.64108219
18positive thymic T cell selection (GO:0045059)3.62548968
19interferon-gamma-mediated signaling pathway (GO:0060333)3.54158214
20regulation of vitamin metabolic process (GO:0030656)3.53305852
21T-helper 1 type immune response (GO:0042088)3.50571021
22regulation of dendritic cell antigen processing and presentation (GO:0002604)3.45368064
23lipopolysaccharide-mediated signaling pathway (GO:0031663)3.43041314
24regulation of T cell tolerance induction (GO:0002664)3.35896659
25positive regulation of type 2 immune response (GO:0002830)3.31536629
26regulation of regulatory T cell differentiation (GO:0045589)3.30927723
27positive regulation of humoral immune response (GO:0002922)3.22678026
28positive regulation of natural killer cell differentiation (GO:0032825)3.21941764
29B cell mediated immunity (GO:0019724)3.17366245
30response to peptidoglycan (GO:0032494)3.15526253
31regulation of cytokine secretion involved in immune response (GO:0002739)3.14557775
32detection of bacterium (GO:0016045)3.12772635
33CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.11938183
34negative regulation of cell killing (GO:0031342)3.10265472
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10265472
36germinal center formation (GO:0002467)3.08796170
37positive regulation of interleukin-17 production (GO:0032740)3.03687485
38myeloid dendritic cell differentiation (GO:0043011)3.03672549
39detection of other organism (GO:0098543)3.02600642
40positive regulation of antigen processing and presentation (GO:0002579)3.02358215
41regulation of antigen processing and presentation (GO:0002577)3.00159163
42positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.99419647
43positive regulation of isotype switching (GO:0045830)2.96238920
44thymic T cell selection (GO:0045061)2.95592494
45regulation of tolerance induction (GO:0002643)2.94489930
46regulation of interleukin-2 biosynthetic process (GO:0045076)2.93747543
47macrophage activation involved in immune response (GO:0002281)2.92404842
48response to muramyl dipeptide (GO:0032495)2.90884020
49activation of MAPKKK activity (GO:0000185)2.90704870
50negative regulation of viral genome replication (GO:0045071)2.90587897
51T cell migration (GO:0072678)2.88408094
52positive regulation of tolerance induction (GO:0002645)2.87120984
53tolerance induction (GO:0002507)2.87069570
54cellular response to interferon-gamma (GO:0071346)2.86624728
55regulation of B cell receptor signaling pathway (GO:0050855)2.85794225
56regulation of interferon-alpha production (GO:0032647)2.85489482
57regulation of interleukin-12 production (GO:0032655)2.85362565
58myeloid dendritic cell activation (GO:0001773)2.84773520
59defense response to protozoan (GO:0042832)2.84475914
60regulation of T cell mediated cytotoxicity (GO:0001914)2.83866389
61lymph node development (GO:0048535)2.83301308
62response to protozoan (GO:0001562)2.82666088
63regulation of gamma-delta T cell activation (GO:0046643)2.82357497
64negative regulation of cytokine production involved in immune response (GO:0002719)2.81684649
65T cell selection (GO:0045058)2.81611736
66regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.81433784
67positive regulation of T cell mediated cytotoxicity (GO:0001916)2.76374852
68regulation of mononuclear cell migration (GO:0071675)2.73886870
69regulation of chemokine biosynthetic process (GO:0045073)2.72577767
70positive regulation of defense response to virus by host (GO:0002230)2.71358627
71regulation of interleukin-12 biosynthetic process (GO:0045075)2.68353889
72response to interferon-gamma (GO:0034341)2.67893467
73positive regulation of T-helper cell differentiation (GO:0045624)2.67778824
74regulation of type I interferon-mediated signaling pathway (GO:0060338)2.67422232
75regulation of T-helper cell differentiation (GO:0045622)2.66290392
76regulation of natural killer cell differentiation (GO:0032823)2.65865747
77regulation of type 2 immune response (GO:0002828)2.65438894
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.63610978
79positive regulation of chemokine biosynthetic process (GO:0045080)2.63156870
80positive regulation of B cell mediated immunity (GO:0002714)2.63115510
81positive regulation of immunoglobulin mediated immune response (GO:0002891)2.63115510
82positive T cell selection (GO:0043368)2.62239475
83positive regulation of interleukin-12 production (GO:0032735)2.60874601
84lymphocyte chemotaxis (GO:0048247)2.60824101
85regulation of T-helper 2 cell differentiation (GO:0045628)2.60623738
86positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.60283152
87regulation of isotype switching (GO:0045191)2.60141494
88negative thymic T cell selection (GO:0045060)2.59676702
89antigen processing and presentation via MHC class Ib (GO:0002475)2.58960607
90positive regulation of T cell differentiation (GO:0045582)2.58555553
91regulation of necroptotic process (GO:0060544)2.56491225
92regulation of T-helper 1 type immune response (GO:0002825)2.54336825
93regulation of defense response to virus by host (GO:0050691)2.53675748
94positive regulation of lymphocyte differentiation (GO:0045621)2.52472759
95JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.52195319
96interferon-gamma secretion (GO:0072643)2.51991930
97negative regulation of nitric oxide biosynthetic process (GO:0045019)2.50600513
98regulation of response to interferon-gamma (GO:0060330)2.50599708
99negative regulation of innate immune response (GO:0045824)2.50550131
100tumor necrosis factor-mediated signaling pathway (GO:0033209)2.49568373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.53783074
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.63046819
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.78799913
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.17484603
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.16389175
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.03163836
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.83886394
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.78421055
9STAT4_19710469_ChIP-ChIP_TH1__Mouse2.67709378
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.52068509
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.50188307
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40886380
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30026897
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27412539
15MYB_26560356_Chip-Seq_TH2_Human2.19311287
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13047585
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.09686688
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.05677879
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04245563
20VDR_21846776_ChIP-Seq_THP-1_Human2.03062330
21MAF_26560356_Chip-Seq_TH1_Human2.00350040
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99844667
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.98299818
24VDR_24763502_ChIP-Seq_THP-1_Human1.92326456
25MYC_22102868_ChIP-Seq_BL_Human1.91744833
26SPI1_23547873_ChIP-Seq_NB4_Human1.89741254
27MYB_26560356_Chip-Seq_TH1_Human1.83530933
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71554002
29UTX_26944678_Chip-Seq_JUKART_Human1.70851804
30RUNX_20019798_ChIP-Seq_JUKART_Human1.70181263
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69933514
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68597315
33MAF_26560356_Chip-Seq_TH2_Human1.66475180
34LXR_22292898_ChIP-Seq_THP-1_Human1.60301764
35STAT1_20625510_ChIP-Seq_HELA_Human1.59792248
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56677406
37SPI1_23127762_ChIP-Seq_K562_Human1.56095050
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.56017314
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55978331
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55551344
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.52930955
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.51897819
43SCL_19346495_ChIP-Seq_HPC-7_Human1.50706334
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.45913182
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44353530
46GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36026758
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35559115
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35450045
49GATA3_26560356_Chip-Seq_TH2_Human1.35333261
50PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34486746
51CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32792873
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32506874
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32384522
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30720782
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30708314
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29411874
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27338439
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27128459
59GATA3_27048872_Chip-Seq_THYMUS_Human1.26710682
60TCF7_22412390_ChIP-Seq_EML_Mouse1.25688545
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25262841
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25230376
63VDR_24787735_ChIP-Seq_THP-1_Human1.24251712
64KDM2B_26808549_Chip-Seq_DND41_Human1.23833468
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23054662
66BCL6_27268052_Chip-Seq_Bcells_Human1.22266003
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22248267
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20373166
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17222584
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17206860
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.16325103
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16252672
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14864186
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14208952
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12543808
76P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12376829
77BCOR_27268052_Chip-Seq_Bcells_Human1.11536438
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11240313
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09977348
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07806648
81GATA1_22025678_ChIP-Seq_K562_Human1.06612524
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06140149
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03916295
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03538197
85PU_27001747_Chip-Seq_BMDM_Mouse1.00638858
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99906744
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99280174
88SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98033769
89PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97872301
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96819370
91RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96676731
92RACK7_27058665_Chip-Seq_MCF-7_Human0.94982042
93CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94917126
94CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94285592
95SA1_27219007_Chip-Seq_ERYTHROID_Human0.94017526
96ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93922006
97CTCF_26484167_Chip-Seq_Bcells_Mouse0.92221377
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90882318
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89539667
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89393244

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.43123262
2MP0003436_decreased_susceptibility_to3.56337438
3MP0005671_abnormal_response_to3.29922404
4MP0009785_altered_susceptibility_to3.17303905
5MP0001835_abnormal_antigen_presentation3.09063054
6MP0009840_abnormal_foam_cell3.08489769
7MP0002148_abnormal_hypersensitivity_rea2.99179666
8MP0003724_increased_susceptibility_to2.85565588
9MP0005000_abnormal_immune_tolerance2.80450743
10MP0005451_abnormal_body_composition2.80168307
11MP0005387_immune_system_phenotype2.71367767
12MP0001790_abnormal_immune_system2.71367767
13MP0003172_abnormal_lysosome_physiology2.61478027
14MP0001800_abnormal_humoral_immune2.61081491
15MP0000685_abnormal_immune_system2.49989131
16MP0009333_abnormal_splenocyte_physiolog2.46433663
17MP0005025_abnormal_response_to2.46149629
18MP0006082_CNS_inflammation2.39855132
19MP0002723_abnormal_immune_serum2.37811709
20MP0005058_abnormal_lysosome_morphology2.37330834
21MP0004510_myositis2.35571350
22MP0002452_abnormal_antigen_presenting2.31858099
23MP0003300_gastrointestinal_ulcer2.22557539
24MP0002419_abnormal_innate_immunity2.18881459
25MP0004947_skin_inflammation2.13169940
26MP0001819_abnormal_immune_cell2.03276668
27MP0003763_abnormal_thymus_physiology2.01971548
28MP0002420_abnormal_adaptive_immunity2.01445464
29MP0010155_abnormal_intestine_physiology1.99078796
30MP0001853_heart_inflammation1.98759536
31MP0002139_abnormal_hepatobiliary_system1.94015333
32MP0001533_abnormal_skeleton_physiology1.89633529
33MP0005310_abnormal_salivary_gland1.85960994
34MP0002405_respiratory_system_inflammati1.85085494
35MP0001845_abnormal_inflammatory_respons1.81877494
36MP0009764_decreased_sensitivity_to1.70472312
37MP0003191_abnormal_cellular_cholesterol1.60850470
38MP0008469_abnormal_protein_level1.57247126
39MP0000716_abnormal_immune_system1.56802453
40MP0002398_abnormal_bone_marrow1.53964908
41MP0003656_abnormal_erythrocyte_physiolo1.53861660
42MP0002933_joint_inflammation1.42320473
43MP0001873_stomach_inflammation1.41913133
44MP0003075_altered_response_to1.40468807
45MP0005464_abnormal_platelet_physiology1.36740480
46MP0003453_abnormal_keratinocyte_physiol1.36279811
47MP0002722_abnormal_immune_system1.30466029
48MP0002254_reproductive_system_inflammat1.30228272
49MP0002429_abnormal_blood_cell1.28629498
50MP0000689_abnormal_spleen_morphology1.27986987
51MP0002138_abnormal_hepatobiliary_system1.26926791
52MP0000858_altered_metastatic_potential1.26813509
53MP0009278_abnormal_bone_marrow1.26580492
54MP0003448_altered_tumor_morphology1.21770090
55MP0005360_urolithiasis1.19712827
56MP0002796_impaired_skin_barrier1.13970255
57MP0002998_abnormal_bone_remodeling1.13845250
58MP0000343_altered_response_to1.10342325
59MP0009763_increased_sensitivity_to1.03370653
60MP0002277_abnormal_respiratory_mucosa1.01434484
61MP0000604_amyloidosis1.00303942
62MP0005410_abnormal_fertilization0.99395785
63MP0003806_abnormal_nucleotide_metabolis0.98219130
64MP0000703_abnormal_thymus_morphology0.96827923
65MP0005390_skeleton_phenotype0.96468983
66MP0005397_hematopoietic_system_phenotyp0.94938515
67MP0001545_abnormal_hematopoietic_system0.94938515
68MP0002132_abnormal_respiratory_system0.94308011
69MP0000249_abnormal_blood_vessel0.91024133
70MP0005167_abnormal_blood-brain_barrier0.90036783
71MP0008007_abnormal_cellular_replicative0.89712026
72MP0003866_abnormal_defecation0.86876649
73MP0002332_abnormal_exercise_endurance0.85444973
74MP0005165_increased_susceptibility_to0.84509898
75MP0005166_decreased_susceptibility_to0.83978935
76MP0001216_abnormal_epidermal_layer0.83774838
77MP0004782_abnormal_surfactant_physiolog0.83565934
78MP0001348_abnormal_lacrimal_gland0.80247931
79MP0005319_abnormal_enzyme/_coenzyme0.79289253
80MP0005164_abnormal_response_to0.74582071
81MP0003828_pulmonary_edema0.73262411
82MP0009765_abnormal_xenobiotic_induced0.72744485
83MP0005023_abnormal_wound_healing0.70956256
84MP0008004_abnormal_stomach_pH0.70392821
85MP0000490_abnormal_crypts_of0.69293602
86MP0002166_altered_tumor_susceptibility0.68974362
87MP0001663_abnormal_digestive_system0.68658341
88MP0002006_tumorigenesis0.68024691
89MP0003195_calcinosis0.67990092
90MP0003091_abnormal_cell_migration0.65728979
91MP0004808_abnormal_hematopoietic_stem0.65059670
92MP0000678_abnormal_parathyroid_gland0.64806180
93MP0009643_abnormal_urine_homeostasis0.62809645
94MP0000609_abnormal_liver_physiology0.62707036
95MP0000681_abnormal_thyroid_gland0.62276041
96MP0002136_abnormal_kidney_physiology0.62246813
97MP0005647_abnormal_sex_gland0.59673371
98MP0005076_abnormal_cell_differentiation0.59143770
99MP0002019_abnormal_tumor_incidence0.58977675
100MP0009931_abnormal_skin_appearance0.56630568

Predicted human phenotypes

RankGene SetZ-score
1Decreased central vision (HP:0007663)5.32728301
2Cone-rod dystrophy (HP:0000548)4.24602526
3Orchitis (HP:0100796)4.03329525
4Myositis (HP:0100614)3.90034817
5Abnormality of glycolipid metabolism (HP:0010969)3.86778818
6Abnormality of liposaccharide metabolism (HP:0010968)3.86778818
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.86778818
8Retrobulbar optic neuritis (HP:0100654)3.85339719
9Optic neuritis (HP:0100653)3.85339719
10Visual hallucinations (HP:0002367)3.82103832
11Decreased electroretinogram (ERG) amplitude (HP:0000654)3.73976996
12Increased IgM level (HP:0003496)3.52326915
13Pulmonary infiltrates (HP:0002113)3.45392636
14Mediastinal lymphadenopathy (HP:0100721)3.38200283
15Chest pain (HP:0100749)3.32442818
16Vasculitis (HP:0002633)3.22007796
17Dysostosis multiplex (HP:0000943)3.14913822
18Gastrointestinal infarctions (HP:0005244)3.13346597
19Gangrene (HP:0100758)3.10634966
20Parakeratosis (HP:0001036)3.06490005
21Stomatitis (HP:0010280)3.04896881
22Microvesicular hepatic steatosis (HP:0001414)3.03191850
23Autoimmune thrombocytopenia (HP:0001973)3.01089989
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.97847294
25Elevated erythrocyte sedimentation rate (HP:0003565)2.96436006
26Abnormality of T cell number (HP:0011839)2.94222830
27Keratoconjunctivitis sicca (HP:0001097)2.91251268
28Increased serum ferritin (HP:0003281)2.88763600
29Progressive neurologic deterioration (HP:0002344)2.86861312
30Pustule (HP:0200039)2.86113917
31Arterial thrombosis (HP:0004420)2.85887655
32Autoimmune hemolytic anemia (HP:0001890)2.83375352
33Recurrent viral infections (HP:0004429)2.83144266
34Abnormality of macrophages (HP:0004311)2.81452341
35Focal motor seizures (HP:0011153)2.81178951
36T lymphocytopenia (HP:0005403)2.78688461
37IgM deficiency (HP:0002850)2.76448996
38Recurrent bacterial skin infections (HP:0005406)2.75907358
39IgA deficiency (HP:0002720)2.75308986
40Increased corneal curvature (HP:0100692)2.74864040
41Keratoconus (HP:0000563)2.74864040
42Keratoconjunctivitis (HP:0001096)2.72918986
43Hemoptysis (HP:0002105)2.72135572
44Meningitis (HP:0001287)2.69897941
45Abnormality of aspartate family amino acid metabolism (HP:0010899)2.65923349
46Systemic lupus erythematosus (HP:0002725)2.65375756
47Increased cerebral lipofuscin (HP:0011813)2.64594250
48Eczematoid dermatitis (HP:0000976)2.62510928
49Recurrent abscess formation (HP:0002722)2.60618457
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.57334591
51Abnormality of the pleura (HP:0002103)2.53563689
52Thoracic kyphosis (HP:0002942)2.53555643
53Abnormality of the prostate (HP:0008775)2.51316501
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.47119781
55Abnormality of polysaccharide metabolism (HP:0011012)2.47119781
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.47119781
57Unilateral renal agenesis (HP:0000122)2.43515255
58Chronic obstructive pulmonary disease (HP:0006510)2.43409099
59Obstructive lung disease (HP:0006536)2.43409099
60IgG deficiency (HP:0004315)2.42543762
61Mucopolysacchariduria (HP:0008155)2.40981987
62Urinary glycosaminoglycan excretion (HP:0003541)2.40981987
63Acute hepatic failure (HP:0006554)2.40501001
64Recurrent fungal infections (HP:0002841)2.40385742
65Abnormality of iron homeostasis (HP:0011031)2.40235677
66Increased IgE level (HP:0003212)2.36444224
67Emphysema (HP:0002097)2.36259772
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.34596477
69Hypergammaglobulinemia (HP:0010702)2.33193033
70Encephalitis (HP:0002383)2.29145741
71Abnormality of the pericardium (HP:0001697)2.24906344
72Abnormal rod and cone electroretinograms (HP:0008323)2.24229754
73Nasal polyposis (HP:0100582)2.18257913
74Interstitial pulmonary disease (HP:0006530)2.18074212
75Anorexia (HP:0002039)2.15743628
76Restrictive lung disease (HP:0002091)2.13216748
77Recurrent bronchitis (HP:0002837)2.12930999
78Abnormality of T cells (HP:0002843)2.12120314
79Urticaria (HP:0001025)2.11495112
80Glomerulopathy (HP:0100820)2.10537582
81Abnormality of transition element cation homeostasis (HP:0011030)2.09717515
82Polyneuropathy (HP:0001271)2.09693078
83Amaurosis fugax (HP:0100576)2.09140981
84Gastrointestinal stroma tumor (HP:0100723)2.07286978
85Chronic diarrhea (HP:0002028)2.07183372
86Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.06802774
87Gingivitis (HP:0000230)2.06644479
88Recurrent skin infections (HP:0001581)2.06561550
89Joint swelling (HP:0001386)2.05814714
90Asymmetric septal hypertrophy (HP:0001670)2.05799222
91Beaking of vertebral bodies (HP:0004568)2.04785648
92Abnormality of the lumbar spine (HP:0100712)2.00111064
93Ureteral stenosis (HP:0000071)1.99524141
94Pulmonary fibrosis (HP:0002206)1.98865852
95Recurrent corneal erosions (HP:0000495)1.98668014
96Colitis (HP:0002583)1.97927152
97Epistaxis (HP:0000421)1.96708715
98Agammaglobulinemia (HP:0004432)1.93961208
99Granulocytopenia (HP:0001913)1.93928796
100Leukocytosis (HP:0001974)1.92629229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.19870745
2IRAK34.17788580
3ERN13.60846418
4MAP3K143.56578707
5NME23.51052267
6MAP4K13.44875838
7IKBKB2.58217881
8PRPF4B2.57315751
9MATK2.41153600
10IRAK42.37052679
11TBK12.33721933
12RIPK42.14270799
13VRK22.01952593
14EPHA22.01949062
15TAOK21.98561843
16IKBKE1.98456487
17GRK71.87394591
18TYK21.83776345
19JAK31.75780466
20MAP3K131.63156393
21CSK1.61330867
22SMG11.51640432
23MST1R1.43555663
24PIM21.40719537
25FES1.38758500
26RIPK11.38509302
27BLK1.36435811
28DDR21.34513337
29TRPM71.34476267
30MAP3K111.30841597
31PBK1.29754227
32TAOK11.23896107
33ZAP701.20318910
34ADRBK21.14981675
35CDC42BPA1.12030051
36CHUK1.08575398
37MAPK111.08554185
38NME11.06571837
39SYK1.05768429
40ITK1.04772828
41BTK1.04337856
42MAP3K31.04053900
43DYRK1B1.02521965
44ICK1.01756954
45CSF1R0.97806887
46LYN0.91506994
47LCK0.90102589
48MAP2K30.87967172
49HCK0.84564617
50STK100.80338426
51HIPK20.76920709
52TESK20.75173451
53JAK10.74704069
54TGFBR20.70875038
55BMX0.69277323
56RPS6KL10.67595124
57RPS6KC10.67595124
58MOS0.66434686
59TRIB30.66312858
60KIT0.64806401
61TESK10.63344244
62JAK20.63340651
63PRKCQ0.61496411
64PIM10.59633604
65DAPK20.59616624
66FGFR40.58959659
67RPS6KA60.54570233
68FGR0.53561012
69IRAK20.51278506
70BMPR20.49221685
71MARK30.49049057
72CLK10.47195609
73GRK60.46647959
74MAP3K10.45524214
75MAP3K50.45011814
76DAPK10.44830664
77MAPK70.44129294
78SIK10.44011177
79TEC0.43657192
80CDK40.43198071
81ABL20.42432775
82TAOK30.40496574
83CDK120.39463458
84ARAF0.39205579
85PDK10.36881120
86NTRK10.35612662
87RPS6KA20.34580381
88IRAK10.34562569
89CDK60.34466618
90MAP2K60.34260872
91MAP2K20.34172188
92PDPK10.34137343
93ABL10.32411158
94SIK20.32192287
95TAF10.31131340
96PRKG20.30010688
97NEK90.29173894
98MET0.28886172
99MAPKAPK20.28647854
100EPHB10.28311992

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.03120554
2Autoimmune thyroid disease_Homo sapiens_hsa053203.70557213
3Graft-versus-host disease_Homo sapiens_hsa053323.42524731
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.17637049
5Asthma_Homo sapiens_hsa053103.13986696
6Type I diabetes mellitus_Homo sapiens_hsa049402.81215408
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.73782896
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.57756940
9Leishmaniasis_Homo sapiens_hsa051402.52396741
10Staphylococcus aureus infection_Homo sapiens_hsa051502.47237396
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.40730071
12Other glycan degradation_Homo sapiens_hsa005112.37507085
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.30231837
14Rheumatoid arthritis_Homo sapiens_hsa053232.23471959
15Primary immunodeficiency_Homo sapiens_hsa053402.18831098
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.15345441
17Antigen processing and presentation_Homo sapiens_hsa046122.11191587
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.93295659
19Viral myocarditis_Homo sapiens_hsa054161.90139517
20Osteoclast differentiation_Homo sapiens_hsa043801.87370642
21Influenza A_Homo sapiens_hsa051641.81609516
22Herpes simplex infection_Homo sapiens_hsa051681.76904348
23TNF signaling pathway_Homo sapiens_hsa046681.75943369
24Toxoplasmosis_Homo sapiens_hsa051451.67233841
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.64042015
26Measles_Homo sapiens_hsa051621.61126950
27Malaria_Homo sapiens_hsa051441.59367215
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48405627
29Hematopoietic cell lineage_Homo sapiens_hsa046401.47964104
30Tuberculosis_Homo sapiens_hsa051521.44839782
31African trypanosomiasis_Homo sapiens_hsa051431.43111693
32B cell receptor signaling pathway_Homo sapiens_hsa046621.38281594
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35095653
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.31276169
35Lysosome_Homo sapiens_hsa041421.26474469
36Pertussis_Homo sapiens_hsa051331.21571686
37T cell receptor signaling pathway_Homo sapiens_hsa046601.20597566
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20086438
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16622340
40Apoptosis_Homo sapiens_hsa042101.05578268
41Legionellosis_Homo sapiens_hsa051341.05125869
42Salmonella infection_Homo sapiens_hsa051321.04251662
43Epstein-Barr virus infection_Homo sapiens_hsa051691.04090671
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03554070
45Shigellosis_Homo sapiens_hsa051310.95658776
46Hepatitis C_Homo sapiens_hsa051600.89149062
47Phototransduction_Homo sapiens_hsa047440.86269691
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83925955
49One carbon pool by folate_Homo sapiens_hsa006700.79464172
50Hepatitis B_Homo sapiens_hsa051610.77315951
51Chemokine signaling pathway_Homo sapiens_hsa040620.76044505
52Acute myeloid leukemia_Homo sapiens_hsa052210.75122996
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74389499
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.73514283
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70859759
56Complement and coagulation cascades_Homo sapiens_hsa046100.69821925
57HTLV-I infection_Homo sapiens_hsa051660.62842794
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61026975
59Prion diseases_Homo sapiens_hsa050200.57001865
60Phagosome_Homo sapiens_hsa041450.56681876
61Systemic lupus erythematosus_Homo sapiens_hsa053220.54737558
62Galactose metabolism_Homo sapiens_hsa000520.49709108
63Bladder cancer_Homo sapiens_hsa052190.43356474
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42287287
65Viral carcinogenesis_Homo sapiens_hsa052030.42226358
66Caffeine metabolism_Homo sapiens_hsa002320.41854711
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41172730
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33895538
69Small cell lung cancer_Homo sapiens_hsa052220.32606079
70Proteasome_Homo sapiens_hsa030500.31315471
71Prolactin signaling pathway_Homo sapiens_hsa049170.29692486
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29584241
73Phenylalanine metabolism_Homo sapiens_hsa003600.28306476
74Insulin resistance_Homo sapiens_hsa049310.28152072
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26467814
76Purine metabolism_Homo sapiens_hsa002300.25566797
77Arachidonic acid metabolism_Homo sapiens_hsa005900.25146562
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25012115
79Chronic myeloid leukemia_Homo sapiens_hsa052200.24997716
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23654532
81Pancreatic cancer_Homo sapiens_hsa052120.23406956
82Mineral absorption_Homo sapiens_hsa049780.23184876
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.22195047
84VEGF signaling pathway_Homo sapiens_hsa043700.21330273
85Endocytosis_Homo sapiens_hsa041440.20248806
86Vitamin digestion and absorption_Homo sapiens_hsa049770.19448075
87Pyrimidine metabolism_Homo sapiens_hsa002400.17074793
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.15944057
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15600028
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15434989
91Amoebiasis_Homo sapiens_hsa051460.15170419
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14795005
93Tryptophan metabolism_Homo sapiens_hsa003800.14402844
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12907481
95RNA polymerase_Homo sapiens_hsa030200.12733236
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12029112
97PPAR signaling pathway_Homo sapiens_hsa033200.11586860
98Sphingolipid metabolism_Homo sapiens_hsa006000.10470190
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.10286330
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.07528633

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