HCG27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.54501760
2negative regulation of cell killing (GO:0031342)6.49044886
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.49044886
4positive regulation by symbiont of host defense response (GO:0052509)6.27300550
5modulation by symbiont of host defense response (GO:0052031)6.27300550
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.27300550
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.27300550
8positive regulation by organism of defense response of other organism involved in symbiotic interact6.27300550
9modulation by symbiont of host immune response (GO:0052553)6.27300550
10positive regulation of gamma-delta T cell activation (GO:0046645)5.85240411
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.82459884
12antigen processing and presentation of endogenous antigen (GO:0019883)5.56183864
13regulation of B cell receptor signaling pathway (GO:0050855)5.21898408
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.20750473
15macrophage activation involved in immune response (GO:0002281)5.03047774
16detection of molecule of bacterial origin (GO:0032490)5.00729901
17detection of other organism (GO:0098543)4.98733529
18neutrophil activation involved in immune response (GO:0002283)4.95494870
19response to interleukin-15 (GO:0070672)4.69512447
20detection of bacterium (GO:0016045)4.67620223
21detection of external biotic stimulus (GO:0098581)4.63489590
22response to peptidoglycan (GO:0032494)4.57425769
23positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.54498810
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.50871904
25microglial cell activation (GO:0001774)4.48967437
26negative regulation of lymphocyte mediated immunity (GO:0002707)4.48946136
27cellular response to interleukin-15 (GO:0071350)4.40399058
28regulation of interferon-beta biosynthetic process (GO:0045357)4.39604692
29response to host immune response (GO:0052572)4.34311106
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.34311106
31cellular extravasation (GO:0045123)4.31545338
32regulation of gamma-delta T cell activation (GO:0046643)4.25933860
33neutrophil activation (GO:0042119)4.19061245
34negative regulation of interleukin-12 production (GO:0032695)4.18237461
35respiratory burst (GO:0045730)4.10264899
36leukocyte aggregation (GO:0070486)4.05575318
37negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.01778513
38detection of biotic stimulus (GO:0009595)4.00891136
39response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.96995656
40response to host (GO:0075136)3.96995656
41response to host defenses (GO:0052200)3.96995656
42neutrophil mediated immunity (GO:0002446)3.94918040
43leukocyte migration involved in inflammatory response (GO:0002523)3.91191446
44regulation of gamma-delta T cell differentiation (GO:0045586)3.89989158
45negative regulation of leukocyte mediated immunity (GO:0002704)3.87055872
46macrophage activation (GO:0042116)3.86997407
47immunoglobulin mediated immune response (GO:0016064)3.78267105
48negative regulation of T cell mediated immunity (GO:0002710)3.74715375
49myeloid cell activation involved in immune response (GO:0002275)3.73996692
50granulocyte activation (GO:0036230)3.71660743
51positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.71003017
52B cell receptor signaling pathway (GO:0050853)3.68242937
53regulation of mast cell degranulation (GO:0043304)3.68073241
54response to type I interferon (GO:0034340)3.62545235
55type I interferon signaling pathway (GO:0060337)3.61412445
56cellular response to type I interferon (GO:0071357)3.61412445
57myeloid leukocyte mediated immunity (GO:0002444)3.48816505
58regulation of myeloid leukocyte mediated immunity (GO:0002886)3.46619992
59regulation of mast cell activation involved in immune response (GO:0033006)3.44895316
60negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.43840210
61negative regulation of T-helper cell differentiation (GO:0045623)3.43840210
62production of molecular mediator involved in inflammatory response (GO:0002532)3.43126674
63negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.42774073
64negative regulation of phagocytosis (GO:0050765)3.37120807
65regulation of B cell differentiation (GO:0045577)3.32579416
66leukocyte degranulation (GO:0043299)3.32578241
67positive regulation of mast cell activation (GO:0033005)3.31210526
68negative thymic T cell selection (GO:0045060)3.25209080
69regulation of mast cell activation (GO:0033003)3.23986636
70regulation of tolerance induction (GO:0002643)3.23035203
71regulation of T cell tolerance induction (GO:0002664)3.22784610
72germinal center formation (GO:0002467)3.21765257
73negative T cell selection (GO:0043383)3.21387381
74regulation of leukocyte degranulation (GO:0043300)3.19299818
75defense response to protozoan (GO:0042832)3.18063423
76positive regulation of T cell mediated cytotoxicity (GO:0001916)3.17847103
77positive regulation of B cell differentiation (GO:0045579)3.15110032
78regulation of T cell mediated cytotoxicity (GO:0001914)3.14582976
79regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.13764054
80positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.13059108
81dendritic cell migration (GO:0036336)3.11300284
82antigen processing and presentation via MHC class Ib (GO:0002475)3.10594700
83positive regulation of interferon-alpha production (GO:0032727)3.10078935
84dendritic cell chemotaxis (GO:0002407)3.08545148
85positive regulation of granulocyte differentiation (GO:0030854)3.06143966
86regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.05305149
87negative regulation of type 2 immune response (GO:0002829)3.04985693
88negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.04297606
89regulation of T-helper 2 cell differentiation (GO:0045628)3.03513248
90B cell mediated immunity (GO:0019724)3.02986222
91response to muramyl dipeptide (GO:0032495)3.01885608
92response to interferon-alpha (GO:0035455)3.00782719
93interferon-gamma-mediated signaling pathway (GO:0060333)2.99913783
94regulation of alpha-beta T cell proliferation (GO:0046640)2.98892705
95positive thymic T cell selection (GO:0045059)2.96933382
96regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.90680003
97positive regulation of toll-like receptor signaling pathway (GO:0034123)2.88432083
98activated T cell proliferation (GO:0050798)2.88101643
99negative regulation of alpha-beta T cell activation (GO:0046636)2.86257418
100regulation of interferon-alpha production (GO:0032647)2.86066901

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.95774832
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.90647370
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.12698938
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.01323743
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.79515740
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.67262351
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.21258296
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.08058340
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.00468965
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.92597247
11RUNX_20019798_ChIP-Seq_JUKART_Human2.85107601
12SPI1_23547873_ChIP-Seq_NB4_Human2.84592642
13SPI1_23127762_ChIP-Seq_K562_Human2.77012467
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.69079770
15SCL_19346495_ChIP-Seq_HPC-7_Human2.68690896
16VDR_21846776_ChIP-Seq_THP-1_Human2.64878368
17VDR_24763502_ChIP-Seq_THP-1_Human2.61914495
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58003376
19MYB_26560356_Chip-Seq_TH2_Human2.57136619
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54553156
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.52716587
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.47971224
23MAF_26560356_Chip-Seq_TH1_Human2.45738264
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.30296973
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.28149687
26* UTX_26944678_Chip-Seq_JUKART_Human2.23255285
27* MYB_26560356_Chip-Seq_TH1_Human2.20015547
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.19313050
29STAT4_19710469_ChIP-ChIP_TH1__Mouse2.16954097
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14846890
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.14141556
32MYC_22102868_ChIP-Seq_BL_Human2.05660581
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99937492
34GATA3_27048872_Chip-Seq_THYMUS_Human1.94848377
35MAF_26560356_Chip-Seq_TH2_Human1.90741085
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86246657
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.84818793
38TCF7_22412390_ChIP-Seq_EML_Mouse1.79377276
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75722270
40VDR_24787735_ChIP-Seq_THP-1_Human1.73482514
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.70541295
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67643123
43KDM2B_26808549_Chip-Seq_DND41_Human1.67223864
44GATA1_19941827_ChIP-Seq_MEL_Mouse1.67060065
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64820459
46GATA1_22025678_ChIP-Seq_K562_Human1.62288652
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.60698950
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.56368248
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52896151
50GATA3_26560356_Chip-Seq_TH2_Human1.50960827
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.50606538
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45592707
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44752921
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44407786
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43487120
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43384799
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.42803292
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42336519
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41348435
60GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39491402
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37398852
62GATA1_19941826_ChIP-Seq_K562_Human1.37078110
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28790887
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28272215
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27168582
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23982385
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23467815
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22882991
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19711436
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18863898
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.17975821
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17846462
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17824430
74PU_27001747_Chip-Seq_BMDM_Mouse1.15914940
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15319262
76GATA2_19941826_ChIP-Seq_K562_Human1.13471695
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11398782
78RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11302718
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10661709
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07965238
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.07941763
82BCL6_27268052_Chip-Seq_Bcells_Human1.07559278
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07557731
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07182284
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.05646323
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03179789
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02480344
88RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98855469
89BCOR_27268052_Chip-Seq_Bcells_Human0.97348164
90IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96836618
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91833787
92SPI1_20517297_ChIP-Seq_HL60_Human0.89718519
93LXR_22292898_ChIP-Seq_THP-1_Human0.89136071
94* NCOR1_26117541_ChIP-Seq_K562_Human0.88845429
95ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84842160
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83146033
97CTCF_27219007_Chip-Seq_ERYTHROID_Human0.80488654
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80470632
99CTCF_21964334_ChIP-Seq_BJAB-B_Human0.78552558
100CIITA_25753668_ChIP-Seq_RAJI_Human0.73260660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.43786058
2MP0003436_decreased_susceptibility_to4.11122484
3MP0001835_abnormal_antigen_presentation3.76815298
4MP0003303_peritoneal_inflammation3.49618675
5MP0002419_abnormal_innate_immunity3.12475757
6MP0001800_abnormal_humoral_immune2.98427380
7MP0005025_abnormal_response_to2.87024875
8MP0009785_altered_susceptibility_to2.77399651
9MP0005671_abnormal_response_to2.77187561
10MP0000685_abnormal_immune_system2.75711553
11MP0005000_abnormal_immune_tolerance2.74278473
12MP0001790_abnormal_immune_system2.70186198
13MP0005387_immune_system_phenotype2.70186198
14MP0002132_abnormal_respiratory_system2.62535895
15MP0002420_abnormal_adaptive_immunity2.61154712
16MP0002723_abnormal_immune_serum2.61050251
17MP0001819_abnormal_immune_cell2.57907614
18MP0003763_abnormal_thymus_physiology2.57179870
19MP0002452_abnormal_antigen_presenting2.48742295
20MP0003300_gastrointestinal_ulcer2.25968515
21MP0004381_abnormal_hair_follicle2.22646101
22MP0008260_abnormal_autophagy2.21090041
23MP0002148_abnormal_hypersensitivity_rea2.17732256
24MP0005464_abnormal_platelet_physiology2.16727854
25MP0006082_CNS_inflammation2.15821104
26MP0003191_abnormal_cellular_cholesterol2.13285976
27MP0002398_abnormal_bone_marrow2.08963413
28MP0002405_respiratory_system_inflammati2.08659719
29MP0001533_abnormal_skeleton_physiology2.01813611
30MP0000716_abnormal_immune_system1.98054407
31MP0002396_abnormal_hematopoietic_system1.88444731
32MP0009278_abnormal_bone_marrow1.81714558
33MP0000465_gastrointestinal_hemorrhage1.81377677
34MP0002722_abnormal_immune_system1.75072386
35MP0010155_abnormal_intestine_physiology1.73028202
36MP0001845_abnormal_inflammatory_respons1.70265687
37MP0003828_pulmonary_edema1.69841316
38MP0000689_abnormal_spleen_morphology1.68835909
39MP0005451_abnormal_body_composition1.68724742
40MP0002277_abnormal_respiratory_mucosa1.67872660
41MP0000703_abnormal_thymus_morphology1.67455600
42MP0003866_abnormal_defecation1.65090077
43MP0004883_abnormal_blood_vessel1.59638857
44MP0002429_abnormal_blood_cell1.58080350
45MP0003172_abnormal_lysosome_physiology1.55102402
46MP0005397_hematopoietic_system_phenotyp1.54631023
47MP0001545_abnormal_hematopoietic_system1.54631023
48MP0004947_skin_inflammation1.48877131
49MP0009764_decreased_sensitivity_to1.47558111
50MP0003183_abnormal_peptide_metabolism1.47403006
51MP0008469_abnormal_protein_level1.39344437
52MP0009333_abnormal_splenocyte_physiolog1.32995836
53MP0005075_abnormal_melanosome_morpholog1.31732499
54MP0000858_altered_metastatic_potential1.29628284
55MP0002166_altered_tumor_susceptibility1.27572979
56MP0001851_eye_inflammation1.23352687
57MP0005164_abnormal_response_to1.21897193
58MP0005310_abnormal_salivary_gland1.17058359
59MP0003656_abnormal_erythrocyte_physiolo1.13008778
60MP0002998_abnormal_bone_remodeling1.09626566
61MP0000015_abnormal_ear_pigmentation1.07924608
62MP0003075_altered_response_to1.04951546
63MP0008004_abnormal_stomach_pH1.02466424
64MP0005166_decreased_susceptibility_to0.97421273
65MP0003806_abnormal_nucleotide_metabolis0.97194006
66MP0000569_abnormal_digit_pigmentation0.93235689
67MP0004510_myositis0.90997504
68MP0003690_abnormal_glial_cell0.90154364
69MP0004808_abnormal_hematopoietic_stem0.89208356
70MP0009763_increased_sensitivity_to0.81488232
71MP0002138_abnormal_hepatobiliary_system0.76277360
72MP0004484_altered_response_of0.75839619
73MP0001663_abnormal_digestive_system0.75674675
74MP0001986_abnormal_taste_sensitivity0.75347974
75MP0005083_abnormal_biliary_tract0.75172966
76MP0003045_fibrosis0.73492185
77MP0002006_tumorigenesis0.73177136
78MP0005390_skeleton_phenotype0.71989931
79MP0008874_decreased_physiological_sensi0.70230059
80MP0005174_abnormal_tail_pigmentation0.69974277
81MP0000343_altered_response_to0.69833955
82MP0004130_abnormal_muscle_cell0.69417461
83MP0001873_stomach_inflammation0.64988144
84MP0001853_heart_inflammation0.64898777
85MP0009765_abnormal_xenobiotic_induced0.64170910
86MP0000490_abnormal_crypts_of0.63964699
87MP0003221_abnormal_cardiomyocyte_apopto0.63599889
88MP0003787_abnormal_imprinting0.61178916
89MP0003448_altered_tumor_morphology0.61164717
90MP0002332_abnormal_exercise_endurance0.60961660
91MP0003795_abnormal_bone_structure0.60761788
92MP0000604_amyloidosis0.60534646
93MP0000249_abnormal_blood_vessel0.60517568
94MP0005058_abnormal_lysosome_morphology0.58888508
95MP0002019_abnormal_tumor_incidence0.57329570
96MP0002933_joint_inflammation0.57269894
97MP0005376_homeostasis/metabolism_phenot0.57064180
98MP0002928_abnormal_bile_duct0.55702267
99MP0005319_abnormal_enzyme/_coenzyme0.54528873
100MP0005377_hearing/vestibular/ear_phenot0.49850513

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.73117545
2Recurrent abscess formation (HP:0002722)6.06036662
3Recurrent bacterial skin infections (HP:0005406)6.04988937
4Myositis (HP:0100614)6.04009232
5Orchitis (HP:0100796)5.73199966
6Retrobulbar optic neuritis (HP:0100654)5.45622853
7Optic neuritis (HP:0100653)5.45622853
8Hypochromic microcytic anemia (HP:0004840)5.08208794
9Stomatitis (HP:0010280)4.94128704
10Abnormality of macrophages (HP:0004311)4.89366848
11Elevated erythrocyte sedimentation rate (HP:0003565)4.87573252
12Recurrent gram-negative bacterial infections (HP:0005420)4.84408259
13Recurrent fungal infections (HP:0002841)4.51693749
14Gastrointestinal infarctions (HP:0005244)4.46498281
15Chronic obstructive pulmonary disease (HP:0006510)4.19105438
16Obstructive lung disease (HP:0006536)4.19105438
17Abnormal delayed hypersensitivity skin test (HP:0002963)4.17583438
18Meningitis (HP:0001287)4.08648769
19Recurrent skin infections (HP:0001581)4.03036916
20Mediastinal lymphadenopathy (HP:0100721)4.00759109
21Keratoconjunctivitis sicca (HP:0001097)3.95283534
22Encephalitis (HP:0002383)3.94531547
23Hypochromic anemia (HP:0001931)3.92438756
24Spontaneous hematomas (HP:0007420)3.89555574
25Recurrent cutaneous fungal infections (HP:0011370)3.75429275
26Chronic mucocutaneous candidiasis (HP:0002728)3.75429275
27Keratoconjunctivitis (HP:0001096)3.69363639
28Prolonged bleeding time (HP:0003010)3.62737285
29Gingivitis (HP:0000230)3.56886508
30T lymphocytopenia (HP:0005403)3.51903671
31Vasculitis (HP:0002633)3.43860971
32Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.39277723
33Increased IgE level (HP:0003212)3.39208115
34Urticaria (HP:0001025)3.37911679
35Abnormality of T cell number (HP:0011839)3.36590265
36Chest pain (HP:0100749)3.29758395
37Gingival bleeding (HP:0000225)3.18928482
38Panhypogammaglobulinemia (HP:0003139)3.18254605
39Cellulitis (HP:0100658)3.16755233
40Arterial thrombosis (HP:0004420)3.11412282
41Episodic fever (HP:0001954)3.08066029
42Leukocytosis (HP:0001974)3.05997384
43Granulocytopenia (HP:0001913)3.04103847
44Peritonitis (HP:0002586)3.03546700
45Microcytic anemia (HP:0001935)3.01145901
46Hemoptysis (HP:0002105)2.97473253
47Epistaxis (HP:0000421)2.97103688
48Abnormality of T cells (HP:0002843)2.93429392
49Inflammation of the large intestine (HP:0002037)2.92958321
50Recurrent viral infections (HP:0004429)2.85982491
51Gastrointestinal inflammation (HP:0004386)2.83118979
52Anorexia (HP:0002039)2.83003637
53Pulmonary embolism (HP:0002204)2.82651718
54Abnormality of the heme biosynthetic pathway (HP:0010472)2.80548332
55Pulmonary infiltrates (HP:0002113)2.77514204
56Eosinophilia (HP:0001880)2.71990367
57Pustule (HP:0200039)2.67180590
58Petechiae (HP:0000967)2.57504773
59Osteomyelitis (HP:0002754)2.54812282
60Increased IgM level (HP:0003496)2.52999316
61Acute hepatic failure (HP:0006554)2.47605883
62Abnormality of T cell physiology (HP:0011840)2.43872877
63Abnormality of the pleura (HP:0002103)2.41633253
64Colitis (HP:0002583)2.37197928
65Sepsis (HP:0100806)2.36340782
66Abnormality of the peritoneum (HP:0002585)2.32298467
67Gangrene (HP:0100758)2.31722264
68Abnormality of eosinophils (HP:0001879)2.21406624
69Chronic otitis media (HP:0000389)2.20748453
70Lymphopenia (HP:0001888)2.19799239
71Slow saccadic eye movements (HP:0000514)2.19165170
72Amyloidosis (HP:0011034)2.15344991
73Toxemia of pregnancy (HP:0100603)2.12888742
74Abnormality of the endocardium (HP:0004306)2.10774386
75Polycythemia (HP:0001901)2.09207008
76Keratitis (HP:0000491)2.07183740
77Abnormality of cells of the lymphoid lineage (HP:0012140)2.05828673
78Glomerulopathy (HP:0100820)2.05685665
79Skin ulcer (HP:0200042)2.05222864
80Hypergammaglobulinemia (HP:0010702)2.04503403
81Recurrent bronchitis (HP:0002837)2.04246033
82Purpura (HP:0000979)2.03135625
83Abnormal platelet volume (HP:0011876)2.02270687
84Abnormality of the pericardium (HP:0001697)2.02171976
85Viral hepatitis (HP:0006562)2.01519862
86Vertigo (HP:0002321)2.01093078
87IgM deficiency (HP:0002850)1.99071907
88Acne (HP:0001061)1.97125129
89Abnormality of iron homeostasis (HP:0011031)1.88141173
90Papilledema (HP:0001085)1.86965129
91Thrombophlebitis (HP:0004418)1.86648004
92Agammaglobulinemia (HP:0004432)1.86408167
93Autoimmune hemolytic anemia (HP:0001890)1.83954647
94Recurrent sinusitis (HP:0011108)1.78398743
95Recurrent pneumonia (HP:0006532)1.77647834
96Increased serum ferritin (HP:0003281)1.77010148
97Difficulty running (HP:0009046)1.77004547
98Skin rash (HP:0000988)1.75764222
99Subacute progressive viral hepatitis (HP:0006572)1.75058699
100Nasal polyposis (HP:0100582)1.73631343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.94270459
2MAP4K13.54492194
3IRAK43.28567399
4BLK3.18611974
5MAP2K33.04825696
6GRK62.82853236
7ERN12.64493882
8FES2.61630814
9CSK2.57091077
10TYK22.56145655
11TNK22.39434566
12EPHB12.32524671
13ZAP702.19173823
14BTK2.08206279
15FGR1.86973683
16HCK1.86123802
17SYK1.82866688
18TXK1.82149381
19MARK31.74173211
20TAOK11.73978241
21JAK31.73067887
22MAP3K31.68639949
23MAP3K11.59467571
24IKBKE1.53573711
25JAK21.50086445
26PRPF4B1.44755370
27MAP3K111.43817979
28TAOK31.40857425
29LYN1.38469714
30KSR21.36834443
31JAK11.31440614
32MAP3K131.25728773
33MAP3K141.21753620
34YES11.20499960
35IRAK11.18787263
36IRAK21.18437255
37TBK11.14853037
38LCK1.13265832
39ITK1.07666889
40PTK2B1.06707745
41MARK21.05306365
42MAP3K21.02829361
43NLK0.98432137
44CSF1R0.98155435
45TEC0.95102199
46KIT0.90670366
47PTK60.88993642
48PDK10.88353195
49SIK20.86980848
50SIK30.86655729
51MATK0.81950555
52MAP3K70.81511289
53PRKD20.79250537
54FGFR30.78877260
55MAP3K60.78014241
56BMPR20.77630173
57PDPK10.73929843
58MAP3K50.73133213
59LRRK20.69899207
60STK380.69435338
61TRIB30.67898029
62PRKCQ0.67601912
63PIK3CG0.66236178
64IKBKB0.65527861
65RAF10.64043895
66STK100.62977529
67SGK30.62872311
68STK110.62645611
69TAOK20.62048349
70HIPK20.62035864
71MAP2K40.61934756
72PINK10.61095516
73SGK20.60722215
74MAPK120.59695121
75FYN0.59274230
76RET0.58001882
77TESK20.56578438
78PIM10.55706660
79DYRK1B0.54183125
80EPHA30.53635900
81DYRK30.50157446
82FGFR40.50089329
83TGFBR20.48487911
84CDK190.47062872
85FRK0.47047932
86MAP2K60.44122414
87KSR10.43070075
88CDC42BPA0.41832011
89STK40.39434531
90WNK10.38594080
91MAPKAPK20.38508681
92PRKG20.37018889
93SGK2230.35895628
94SGK4940.35895628
95SMG10.34962219
96CAMKK20.34761069
97CAMKK10.33527114
98CAMK40.31759913
99DAPK20.31614002
100RPS6KC10.31234182

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.97643425
2Osteoclast differentiation_Homo sapiens_hsa043802.96467771
3Staphylococcus aureus infection_Homo sapiens_hsa051502.67691770
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.50064032
5B cell receptor signaling pathway_Homo sapiens_hsa046622.45132024
6Primary immunodeficiency_Homo sapiens_hsa053402.33984200
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.18965990
8Tuberculosis_Homo sapiens_hsa051522.18518896
9Graft-versus-host disease_Homo sapiens_hsa053322.18357256
10Allograft rejection_Homo sapiens_hsa053302.14932208
11Malaria_Homo sapiens_hsa051442.02033765
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.01901201
13Autoimmune thyroid disease_Homo sapiens_hsa053202.00893554
14Measles_Homo sapiens_hsa051621.92626976
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91027690
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.88979481
17Acute myeloid leukemia_Homo sapiens_hsa052211.81828544
18T cell receptor signaling pathway_Homo sapiens_hsa046601.80297938
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75739983
20Hematopoietic cell lineage_Homo sapiens_hsa046401.70676501
21Chemokine signaling pathway_Homo sapiens_hsa040621.68551556
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.61585963
23Type I diabetes mellitus_Homo sapiens_hsa049401.54570256
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.49843048
25African trypanosomiasis_Homo sapiens_hsa051431.46506935
26Influenza A_Homo sapiens_hsa051641.45713917
27Antigen processing and presentation_Homo sapiens_hsa046121.45665896
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44038220
29Non-small cell lung cancer_Homo sapiens_hsa052231.43697884
30Legionellosis_Homo sapiens_hsa051341.42311011
31Herpes simplex infection_Homo sapiens_hsa051681.41389448
32Toxoplasmosis_Homo sapiens_hsa051451.41027042
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35259656
34Phagosome_Homo sapiens_hsa041451.34016379
35Platelet activation_Homo sapiens_hsa046111.33236776
36Viral myocarditis_Homo sapiens_hsa054161.32577515
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26619471
38Hepatitis B_Homo sapiens_hsa051611.22599583
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.20289764
40TNF signaling pathway_Homo sapiens_hsa046681.17835228
41Hepatitis C_Homo sapiens_hsa051601.15818690
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05296309
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.04364941
44Apoptosis_Homo sapiens_hsa042101.00652374
45Pancreatic cancer_Homo sapiens_hsa052121.00550259
46VEGF signaling pathway_Homo sapiens_hsa043700.96354550
47Chronic myeloid leukemia_Homo sapiens_hsa052200.93033361
48Asthma_Homo sapiens_hsa053100.89589014
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87346601
50Prolactin signaling pathway_Homo sapiens_hsa049170.86431398
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84958929
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84847811
53FoxO signaling pathway_Homo sapiens_hsa040680.84478517
54Pertussis_Homo sapiens_hsa051330.84364428
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83380641
56Endometrial cancer_Homo sapiens_hsa052130.81876722
57Shigellosis_Homo sapiens_hsa051310.81272565
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80984118
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.80280359
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.79596828
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79090450
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75797413
63Endocytosis_Homo sapiens_hsa041440.75576139
64Salmonella infection_Homo sapiens_hsa051320.75378561
65Viral carcinogenesis_Homo sapiens_hsa052030.75108511
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72945966
67Dorso-ventral axis formation_Homo sapiens_hsa043200.69881864
68Renal cell carcinoma_Homo sapiens_hsa052110.69781632
69Other glycan degradation_Homo sapiens_hsa005110.67879670
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.67335015
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67032568
72Regulation of autophagy_Homo sapiens_hsa041400.66363483
73mTOR signaling pathway_Homo sapiens_hsa041500.64357163
74Choline metabolism in cancer_Homo sapiens_hsa052310.64307876
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61467681
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61435099
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.60814867
78Inositol phosphate metabolism_Homo sapiens_hsa005620.60496018
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59747176
80Epstein-Barr virus infection_Homo sapiens_hsa051690.58644894
81Rheumatoid arthritis_Homo sapiens_hsa053230.58411237
82Insulin resistance_Homo sapiens_hsa049310.56690673
83GnRH signaling pathway_Homo sapiens_hsa049120.56634565
84Type II diabetes mellitus_Homo sapiens_hsa049300.56021780
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54996395
86Notch signaling pathway_Homo sapiens_hsa043300.54590577
87Colorectal cancer_Homo sapiens_hsa052100.51177150
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.51009252
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50276310
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49134339
91HIF-1 signaling pathway_Homo sapiens_hsa040660.48832614
92MAPK signaling pathway_Homo sapiens_hsa040100.48746451
93HTLV-I infection_Homo sapiens_hsa051660.47973293
94Olfactory transduction_Homo sapiens_hsa047400.44871427
95Glioma_Homo sapiens_hsa052140.43509691
96Rap1 signaling pathway_Homo sapiens_hsa040150.43411570
97Prostate cancer_Homo sapiens_hsa052150.43316715
98ErbB signaling pathway_Homo sapiens_hsa040120.42534474
99Long-term potentiation_Homo sapiens_hsa047200.42162773
100Amoebiasis_Homo sapiens_hsa051460.38431402

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »